KR101922741B1 - 생물학적 물질의 고도로 특이적인 포획 및 방출을 위한 방법 및 조성물 - Google Patents
생물학적 물질의 고도로 특이적인 포획 및 방출을 위한 방법 및 조성물 Download PDFInfo
- Publication number
- KR101922741B1 KR101922741B1 KR1020137023006A KR20137023006A KR101922741B1 KR 101922741 B1 KR101922741 B1 KR 101922741B1 KR 1020137023006 A KR1020137023006 A KR 1020137023006A KR 20137023006 A KR20137023006 A KR 20137023006A KR 101922741 B1 KR101922741 B1 KR 101922741B1
- Authority
- KR
- South Korea
- Prior art keywords
- molecule
- hydrogel composition
- polyethylene glycol
- biological material
- alginic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/548—Carbohydrates, e.g. dextran
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
- B01F25/4317—Profiled elements, e.g. profiled blades, bars, pillars, columns or chevrons
- B01F25/43172—Profiles, pillars, chevrons, i.e. long elements having a polygonal cross-section
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
- B01F25/43197—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor characterised by the mounting of the baffles or obstructions
- B01F25/431971—Mounted on the wall
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0636—Focussing flows, e.g. to laminate flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/069—Absorbents; Gels to retain a fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Inorganic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161439166P | 2011-02-03 | 2011-02-03 | |
| US61/439,166 | 2011-02-03 | ||
| PCT/US2012/023859 WO2012106658A1 (en) | 2011-02-03 | 2012-02-03 | Methods and compositions for highly specific capture and release of biological materials |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140016896A KR20140016896A (ko) | 2014-02-10 |
| KR101922741B1 true KR101922741B1 (ko) | 2019-02-20 |
Family
ID=46603107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137023006A Active KR101922741B1 (ko) | 2011-02-03 | 2012-02-03 | 생물학적 물질의 고도로 특이적인 포획 및 방출을 위한 방법 및 조성물 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9927334B2 (https=) |
| EP (1) | EP2670856B1 (https=) |
| JP (2) | JP6120778B2 (https=) |
| KR (1) | KR101922741B1 (https=) |
| ES (1) | ES2687144T3 (https=) |
| SG (2) | SG10201600803SA (https=) |
| WO (1) | WO2012106658A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014072465A1 (en) | 2012-11-09 | 2014-05-15 | Roche Diagnostics Gmbh | In vitro capture and analysis of circulating tumor cells |
| EP2951585B1 (en) | 2013-02-01 | 2018-01-03 | The General Hospital Corporation | Capture and release of particles from liquid samples |
| US20170074870A1 (en) | 2014-03-14 | 2017-03-16 | Northeastern University | Microfluidic System and Method for Real-Time Measurement of Antibody-Antigen Binding and Analyte Detection |
| WO2015148512A1 (en) | 2014-03-24 | 2015-10-01 | Qt Holdings Corp | Shaped articles including hydrogels and methods of manufacture and use thereof |
| US11583860B2 (en) * | 2014-12-22 | 2023-02-21 | Ecole Polytechnique Federale De Lausanne (Epfl) | Microstructured thin hydrogel films |
| US9790467B2 (en) | 2015-09-22 | 2017-10-17 | Qt Holdings Corp | Methods and compositions for activation or expansion of T lymphocytes |
| EP3378945B1 (en) * | 2015-12-14 | 2021-04-28 | Quanta Matrix Co., Ltd. | Method for distinguishing particular cells from mixture of heterogeneous cells |
| CN109154614B (zh) * | 2016-03-18 | 2022-01-28 | 四方控股公司 | 用于细胞分离的组合物、装置和方法 |
| US10429387B2 (en) * | 2016-07-27 | 2019-10-01 | Universiteit Tweate | Simple and affordable method for immuophenotyping using a microfluidic chip sample preparation with image cytometry |
| US11118163B2 (en) | 2017-02-02 | 2021-09-14 | Sartorius Stedim Biotech Gmbh | Separation of cell populations by marker identification and sedimentation velocity |
| DE102017105195A1 (de) | 2017-03-10 | 2018-09-13 | Leibniz-Institut Für Polymerforschung Dresden E.V. | Verfahren zur differenzierten Sequestrierung von Stoffen verschiedener Stoffgruppen mit Hilfe von sulfatierte oder sulfonierte Komponenten enthaltenden Hydrogelen |
| KR20190138646A (ko) * | 2017-03-20 | 2019-12-13 | 큐티 홀딩스 코포레이션 | 면역 세포의 조절을 위한 방법 및 조성물 |
| WO2019239359A2 (en) | 2018-06-13 | 2019-12-19 | University Of Washington | Extruded hydrogel tubes and coaxial fibers and applications thereof |
| EP3626814B1 (en) * | 2018-09-21 | 2023-03-08 | Technische Universität Wien | Production of cellular spheroids |
| JP7120547B2 (ja) * | 2019-02-22 | 2022-08-17 | 国立研究開発法人理化学研究所 | 物質固定化剤、及び当該物質固定化剤を用いた物質固定化方法 |
| US11976269B2 (en) * | 2019-03-18 | 2024-05-07 | Cellular Research, Inc. | Precise delivery of components into fluids |
| US11668676B2 (en) * | 2019-05-30 | 2023-06-06 | The Regents Of The University Of California | Microfluidic acoustic devices and methods |
| CN112708150B (zh) * | 2020-12-08 | 2021-11-16 | 济南国科医工科技发展有限公司 | 用于循环肿瘤细胞的捕获及定点释放的水凝胶体系 |
| WO2023034430A1 (en) | 2021-09-01 | 2023-03-09 | Bio-Techne Corporation | Human vitronectin fragments and uses thereof |
| US11805995B1 (en) | 2022-11-22 | 2023-11-07 | King Faisal University | Saliva collection kit |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998012228A1 (en) | 1996-09-19 | 1998-03-26 | The Regents Of The University Of Michigan | Polymers containing polysaccharides such as alginates or modified alginates |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2466116C (en) * | 2001-11-07 | 2012-04-24 | Eidgenossisch Technische Hochschule Zurich | Synthetic matrix for controlled cell ingrowth and tissue regeneration |
| MXPA04006021A (es) * | 2001-12-18 | 2005-08-19 | Eth Zuerich | Matrices de proteina modificada con factor de crecimiento para ingenieria de tejidos. |
| AU2003248273A1 (en) * | 2002-07-12 | 2004-02-02 | Mitsubishi Chemical Corporation | Analytical chip, analytical chip unit, analyzing apparatus, method of analysis using the apparatus, and method of producing the analytical chip |
| CA2500392C (en) | 2002-09-27 | 2012-11-27 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
| EP2946666B1 (en) * | 2004-04-30 | 2017-11-15 | OrbusNeich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods of using same |
| SE0402476D0 (sv) * | 2004-10-13 | 2004-10-13 | Biacore Ab | Preparation and use of a reactive solid support surface |
| CN101338036B (zh) | 2007-07-06 | 2010-11-03 | 常州百瑞吉生物医药有限公司 | 生物相容快速凝胶化水凝胶及其喷雾剂的制备方法 |
| JP2011505802A (ja) | 2007-12-10 | 2011-03-03 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | パターニングされた細胞シート及びその製造方法 |
| US20120077246A1 (en) * | 2009-04-24 | 2012-03-29 | The Board Of Trustees Of The University Of Illinoi | Methods and Devices for Capturing Circulating Tumor Cells |
| US20140154703A1 (en) * | 2011-01-06 | 2014-06-05 | Alison Skelley | Circulating tumor cell capture on a microfluidic chip incorporating both affinity and size |
-
2012
- 2012-02-03 ES ES12742728.4T patent/ES2687144T3/es active Active
- 2012-02-03 JP JP2013552696A patent/JP6120778B2/ja active Active
- 2012-02-03 US US13/982,680 patent/US9927334B2/en active Active
- 2012-02-03 SG SG10201600803SA patent/SG10201600803SA/en unknown
- 2012-02-03 KR KR1020137023006A patent/KR101922741B1/ko active Active
- 2012-02-03 EP EP12742728.4A patent/EP2670856B1/en active Active
- 2012-02-03 WO PCT/US2012/023859 patent/WO2012106658A1/en not_active Ceased
- 2012-02-03 SG SG2013058797A patent/SG192587A1/en unknown
-
2016
- 2016-12-08 JP JP2016238320A patent/JP2017077245A/ja not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998012228A1 (en) | 1996-09-19 | 1998-03-26 | The Regents Of The University Of Michigan | Polymers containing polysaccharides such as alginates or modified alginates |
Non-Patent Citations (1)
| Title |
|---|
| PLOUFFE, B.D 등, Lab on a Chip. 2009, 제9권 제1507-1510면. |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2670856A4 (en) | 2014-12-03 |
| US9927334B2 (en) | 2018-03-27 |
| ES2687144T3 (es) | 2018-10-23 |
| EP2670856A1 (en) | 2013-12-11 |
| JP2017077245A (ja) | 2017-04-27 |
| WO2012106658A1 (en) | 2012-08-09 |
| KR20140016896A (ko) | 2014-02-10 |
| EP2670856B1 (en) | 2018-06-27 |
| JP2014506671A (ja) | 2014-03-17 |
| SG10201600803SA (en) | 2016-03-30 |
| SG192587A1 (en) | 2013-09-30 |
| US20140057280A1 (en) | 2014-02-27 |
| JP6120778B2 (ja) | 2017-04-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101922741B1 (ko) | 생물학적 물질의 고도로 특이적인 포획 및 방출을 위한 방법 및 조성물 | |
| Dos Reis et al. | Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia | |
| AU2018390960B2 (en) | Immune cell organoid co-cultures | |
| Kwizera et al. | Greatly enhanced CTC culture enabled by capturing CTC heterogeneity using a PEGylated PDMS–Titanium–Gold electromicrofluidic device with glutathione-controlled gentle cell release | |
| US20100055733A1 (en) | Manufacture and uses of reactive microcontact printing of biomolecules on soft hydrogels | |
| KR102029156B1 (ko) | 순환종양세포 검출용 미세유체칩 | |
| Roccio et al. | High-throughput clonal analysis of neural stem cells in microarrayed artificial niches | |
| EP3017301B1 (en) | Microtissues | |
| WO2013056090A1 (en) | Affinity-based materials for the non-destructive separation and recovery of cells | |
| JP2026009937A (ja) | 細胞を選択する方法 | |
| Mills-Goodlet et al. | Biological effects of allergen–nanoparticle conjugates: uptake and immune effects determined on hAELVi cells under submerged vs. air–liquid interface conditions | |
| US20260083776A1 (en) | Activation and proliferation of cytotoxic lymphocytes | |
| Lussier et al. | PiP‐Plex: A Particle‐in‐Particle System for Multiplexed Quantification of Proteins Secreted by Single Cells | |
| Ryoo | Microenvironmental modification and analysis of 3D cell culture using microgels | |
| KR101616705B1 (ko) | 특이적 결합분자―나노섬유 복합체 및 이를 이용한 세포활성화 방법 | |
| US20260071176A1 (en) | Universal Efficient Dextran Microparticles Production with Microfluidic Technology | |
| Hatch | Microfluidic isolation of endothelial progenitor cells for vascular tissue engineering | |
| Hirth | Development of a microfluidic platform to emulate the human microvasculature | |
| Cho et al. | Fabrication of single cell microarrays on a double-layered hydrogel for mitochondrial activity monitoring | |
| Silangcruz | Micropatterned Aptamer-Containing Surfaces for Capturing CD4 T-cells | |
| Marek et al. | Surface-functionalized nanodiamonds for tailoring divergent osteo-immune and angiogenic responses via macrophage polarization | |
| KR20250154508A (ko) | 미세유기구에서의 세포 표지 및 주석 | |
| Kevlahan | A microfluidic capture and release method for isolation intestinal progenitor and stem cells from native rat tissue enabling advances in vasculogenic co-cultures | |
| Lilly | Surface-initiated polymerizations for the rapid sorting of rare cancer cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| R17-X000 | Change to representative recorded |
St.27 status event code: A-3-3-R10-R17-oth-X000 |
|
| A201 | Request for examination | ||
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 4 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 5 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 6 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 7 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 8 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE) Year of fee payment: 8 |