KR101905518B1 - A cosmetics composition comprising extracellular matrix-polysiloixane complex and a preparing method thereof - Google Patents

Abstract

The present invention relates to a cosmetic composition comprising an extracellular matrix-siloxane polymer and to a preparation method thereof, and more particularly, to a cosmetic composition comprising an extracellular matrix-siloxane polymer, which improved air permeability and film performance in skin by comprising a structure composed of extracellular matrix and platinum-catalyzed crosslinked silicon, and to a preparation method thereof. The composition of the present invention contains the extracellular matrix-siloxane polymer (skin mimetic) as the cosmetic composition in the form of an underwater type emulsion, and thus it is possible to provide film-forming ability on the skin and to impart breathability, thereby transferring a useful component of the skin to the skin without worrying about skin irritation and imparting a moisturizing effect.

Description

A cosmetic composition comprising an extracellular matrix-polysiloxane polymer and a preparing method thereof,

The present invention relates to a cosmetic composition containing an extracellular matrix-siloxane polymer and a process for producing the same.

The main role of the epidermis, which contains various extracellular substrates such as proteoglycans, hyaluronic acid, and collagen, and ceramide, a liquid crystal membrane using phospholipids, and natural moisture factors, protects the body's moisture, To protect the skin from the barrier function. The epidermal layer, which acts as a skin barrier, maintains the homeostasis of the skin by constantly repeating the epidermal cell formation, differentiation and eradication processes. These extracellular matrices reside in the dermal and mucosal layers of the skin, maintain the elasticity of the dermis and mucosal tissues, and act as basal matrices in cell proliferation and soft tissue formation (Casser-Bette et al., Bone formation by osteoblast-like cells in a three dimensional cell cuture, Clacif Tissu Int ., 46: 46-56).

However, these matrix structures are not structurally stable, and there is a problem that extracellular matrix components are easily decomposed and released from the structure. In order to overcome such disadvantages, liquid crystal technology using various water soluble polymers (polyacrylic, agar gel, carrageenan gel) resins or natural lipid components has been used as a structure (Patent Application No. 0060318, Jun. 23, 2011 Patent Application No. < RTI ID = 0.0 > 0035850, < / RTI >

However, when such a water-soluble polymer or liquid crystal is mixed with a component constituting the cosmetic composition, it is diluted or solubility is lost and its effect is limited due to its loss of property or high sealing property at a high content. In addition, structure technology using an oil-soluble silicone gel having excellent skin-affinity has been introduced, but its application is limited because it is a silicone gel patch formulation using a crosslinked silicone film or nonwoven fabric as a support, and thus can not be applied to ordinary cosmetics.

The skin primer film applied to the cosmetic composition should be firm and unstructured due to the ingredients of the cosmetic composition, unlike the simple mixture, and promotes the skin absorption of the air permeability and skin cosmetic ingredients to improve moisturizing, nutrition, wrinkle improvement, Up, whitening, and so on.

Accordingly, there is a demand for a cosmetic composition containing a skin primer film which contains various extracellular matrix components, maintains a solid membrane structure property and is not decomposed by a cosmetic composition and has excellent breathability and moisturizing properties .

In order to overcome such conventional problems, the present invention relates to a cosmetic composition which is similar to a skin cell, and has extracellular matrix components such as collagen, proteoglycans, and phospholipids supported on a rigid polysiloxane structure to prevent evaporation of moisture of the skin, A protective effect, and a sunscreen showing a synergistic effect of sun protection factor, and a process for producing the cosmetic composition.

To achieve these objects, the present invention provides an underwater-type cosmetic composition comprising as an active ingredient a siloxane polymer, an extracellular matrix component, a rheology control agent, and a skin cosmetic ingredient.

In one embodiment of the invention, the composition comprises 0.01 to 15.0 wt% of a siloxane polymer, 0.01 to 10.0 wt% of an extracellular matrix component, 0.1 to 10.0 wt% of an emollient oil, 0.01 to 1.0 wt% of a rheology modifier, Wherein the cosmetic composition is an underwater type cosmetic composition comprising 0.01 to 10.0% by weight of an emulsifier, 0.01 to 10.0% by weight of an emulsifier, 1.0 to 30.0% by weight of a skin cosmetic ingredient, 1.0 to 20.0% by weight of a polyhydric alcohol, But not limited to this.

In another embodiment of the present invention, the siloxane polymer is preferably, but not limited to, vinyl dimethicone, silica, colloidal platinum, or hydrogendimethicone.

In another embodiment of the present invention, the extracellular matrix component is selected from the group consisting of proteoglycan, collagen, phospholipids, and components of amino acids, saccharide isomerate, and tremelapaxiposus polysaccharide But is not limited thereto.

In one embodiment of the present invention, the amino acid component is preferably at least one selected from the group consisting of serine, glycine, arginine, glutamic acid, tyrosine and alanine, but is not limited thereto.

In another embodiment of the present invention, the rheology modifier component is preferably at least one selected from the group consisting of oxidized amines, ceramides, polyacrylamides, lipoic acid, and lipoic acid PEG derivatives, but is not limited thereto.

In another embodiment of the present invention the skin cosmetic ingredient is selected from the group consisting of adenosine, retinol, arbutin, hyaluronic acid, tocopherol, 7-dihydrocholesterol, march extract, tocopheryl acetate, niacinamide, ascorbic acid, ascorbyl glucoside, and EGCG , But is not limited thereto.

The composition of the present invention is characterized in that the extracellular matrix and the siloxane polymer form a complex, and the composition of the present invention maintains breathability and moisturizing properties when applied to the skin.

The present invention also provides a process for preparing a cosmetic composition comprising a complex of an extracellular matrix and a siloxane polymer comprising the steps of:

(a) emulsifying a mixture of water, wax, rheology control agent, emollient oil and emulsifier in a silicone liquid containing a crosslinking site to obtain a liquid mixture of oil-in-water type;

(b) blending a liquid mixture of silicone fluid in a water-in-oil form containing an extracellular matrix component and a crosslinking catalyst into the mixture of (a); And

(c) mixing a skin cosmetic ingredient with a mixture solution comprising the cross-linked extracellular matrix-siloxane polymer of (a) and (b) to obtain a cosmetic composition of the oil-in-water type.

In one embodiment of the present invention, the silicone liquid containing the crosslinking site is a mixture of vinyl dimethicone, silica, and hydrogen dimethicone.

In another embodiment of the present invention, the silicone liquid in the water-in-oil form containing the crosslinking catalyst is a mixture of vinyl dimethicone, silica, and colloidal platinum.

Suitable emulsifiers of the present invention are well known in the art and include nonionic, anionic, amphoteric, zwitterionic, cationic emulsifiers, and mixtures thereof. Examples of emulsifiers also include natural or synthetic polymer emulsifiers.

Anionic emulsifiers include alkyl and alkyl ethers, such as alkyl and alkyl ether sulfates, alkyl sulfonates, alkyl and alkyl ether phosphates, alkyl or alkyl ether sulfosuccinates, citrers, tartar or sulfosuccinic esters of alkyl polyglucosides Carboxylates and anionic derivatives of alkyl polyglycosides.

Nonionic emulsifiers can be broadly defined as compounds containing hydrophobic moieties and nonionic hydrophilic moieties. Examples of hydrophobic moieties may be alkyl, alkylaromatic, and arylaromatic. Examples of hydrophilic moieties include polyoxyalkylene, amine oxides, and alkanolamides. Examples of non-ionic emulsifiers are alkoxylated fatty alcohols or fatty acids, alkoxylated di- and tri-styrylphenols, polyhydroxy fatty acid amides, sugar esters and polyesters, alkoxylated sugar esters, sorbitan and alkoxy Miscible sorbitan fatty acid esters. Other examples of nonionic emulsifiers include alkyl polyglycosides, such as coco polyglucoside.

Cationic emulsifiers also contain amino or quaternary ammonium hydrophilic moieties, which are positively charged when dissolved in water. Examples of ammonium compounds are long chain alkyl trimethyl ammonium chloride, long chain alkyl benzyl dimethyl ammonium chloride, alkyl amine hydrochloride, alkyl amine acetate and di (long chain alkyl) dimethyl ammonium bromide. Amphoteric emulsifiers that can be used in the compositions of the present invention are those broadly described as derivatives of aliphatic quaternary ammonium, wherein one of the aliphatic substituents is an anionic water-soluble group, such as carboxylate, Nate, and Sulfate. Examples of amphoteric surfactants include cocoamphocarboxy propionate, cocoamphoacetate, cocoamphodiacetate, sodium lauroamphoacetate.

Examples of bidentate surfactants include alkyl betaines and amido betaines, alkyl sultaines, alkyl glycinates and alkyl carboxy glycinates.

Additional examples of suitable emulsifiers that may be used in the compositions of the present invention are described in "McCutcheon's Detergents and Emulsifiers ", North American Edition (2003), Allured Publishing Corporation.

The composition according to the invention may optionally also contain other additives commonly used in the cosmetics industry such as colorants, preservatives (for example imidazolidinyl urea, diazolidinyl urea, phenoxyethanol, methyl paraben, ethyl paraben, Suspending agents (such as clay, silica and xanthan), silicone materials, hydrocarbon polymers, agents, and mixtures thereof may be included in the compositions of the present invention. have.

Hereinafter, the present invention will be described.

Representative characteristics of the siloxane polymer composition used in the present invention are as follows.

(1) The siloxane polymer composition used in the present invention is a metal catalyst-crosslinked silicone pressure-sensitive adhesive such as platinum, which is a dimethicone derivative in which a part of the methyl group is substituted with a vinyl group. Silicone silicone elatomer (HCR, LSR) such as bisvinyl dimethicone, vinyl dimethicone, or hydrogendimethicone, which is a representative raw material currently used, is representative, and siloxane polymers having a similar system are all applicable.

(2) a reaction using a metal catalyst such as platinum to increase the reactivity of the organometallic compound, and the reaction is carried out using an oxidative addition (hydrosilylation) reaction between SiH and the vinyl end group polymer between silicon polymers Polymers are formed and structurally breathable.

The present inventors have intensively carried out extracellular matrix components such as collagen, proteoglycans, phospholipids and amino acids in the form of a water-in-oil type in the inside of the cross-linked polymeric silicone polymer structure and finally realized the composition as an underwater type cosmetic composition, And to overcome the problem that the structure is decomposed by the constituents of cosmetic ingredients and the convenience of use.

Also, application of a rheology modifier to solve the problem that the ultimate flow property (quality) of the cosmetic composition due to the siloxane polymer changes.

The siloxane polymer contained in the present invention may contain 0.01 to 15.0% by weight based on the total weight of the cosmetic composition. If the amount of the siloxane polymer is less than 0.01% by weight, the skin primer film formation property may be weak. If the siloxane polymer is more than 15.0% by weight, the flow property of the crosslinked silicone gel becomes too strong, This does not meet expectations.

In order to control the flow characteristics of the siloxane polymer generated in the cosmetic composition, it is possible to use an amine, a ceramide, a polyacrylamide, a lipoic acid, a lipoic acid PEG derivative or the like having a terminal group that gives electrons as a rheology modifier , The rheology modifiers may be combined with a crosslinking catalyst to deactivate the catalyst to control the curing of the cosmetic composition.

The rheology modifier can suppress the flow characteristics of the crosslinked silicone gel in the cosmetic composition to obtain uniform properties over a long period of time. The rheology modifier contained in the present invention may contain 0.01 to 1.0% by weight based on the total weight of the cosmetic composition. When the rheology control agent is 0.01% by weight or less, the interference strength between the terminal group and the bonding agent is weak and the rheology change may not be affected. When the ratio is 1.0% by weight or more, the blocking strength between the terminal group and the bonding agent The desired siloxane polymer can not be obtained because the strong crosslinking reaction is inhibited.

In addition, the extracellular matrix component contained in the siloxane polymer may contain components such as proteoglycan, collagen, phospholipid, amino acid, saccharide isomerate, and tremella fuciformis polysaccharide.

In addition, as a cosmetic ingredient for skin, a cosmetic composition containing ingredients having functions of improving wrinkles, whitening, moisturizing and nourishing such as adenosine, arbutin, hyaluronic acid, tocopherol, 7-dihydrocholesterol, horseradish, tocopheryl acetate, , Ascorbic acid, ascorbyl glucoside, EGCG, and the like, but the present invention is not limited thereto.

The present invention provides a composition comprising 0.01 to 15.0 wt% of a siloxane polymer, 0.01 to 10.0 wt% of an extracellular matrix component, 0.01 to 1.0 wt% of a rheology inhibitor, 0.01 to 10.0 wt% of wax, 0.1 to 10.0 wt% of an emollient oil, The present invention relates to a cosmetic composition of the water type type containing 0.01 to 10.0% by weight of a nonionic emulsifier, 1.0 to 30.0% by weight of a skin cosmetic ingredient, 1.0 to 20.0% by weight of a polyhydric alcohol, a preservative, a perfume and a solvent.

Further, the present invention is characterized by realizing a thin extracellular matrix-siloxane polymer (skin primer film) having permeability to the skin after application of the cosmetic composition.

The cosmetic composition comprising the extracellular matrix-siloxane polymer (skin mimetic) of the present invention prevents evaporation of moisture on the skin and forms a film through which air passes to provide excellent moisturizing effect, skin protection effect, and various skin cosmetic ingredients To improve skin wrinkles, whitening, moisturizing, anti-trouble, and superior sun protection synergistic effect.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is an electron micrograph of the surface and cross-section of an extracellular matrix-siloxane polymer (skin mimicking substance).
2 is a graph of the change in the permeability of the extracellular matrix-siloxane polymer (skin mimicking substance).
FIG. 3 is a graph showing the effect of enhancing ultraviolet shielding after application of a skin cosmetic composition containing an extracellular matrix-siloxane polymer (skin mimetic).

Hereinafter, the structure of the present invention will be described in more detail with reference to specific examples. The present invention has been made in view of the above problems, and it is an object of the present invention to provide an apparatus and method for controlling the same. However, it should be apparent to those skilled in the art that the scope of the present invention is not limited by the description of the embodiments.

The extracellular matrix-siloxane polymer of the present invention (skin primer film) simulates the structural characteristics of skin cells constituting skin barrier in a mortar form. For this purpose, a rigid structure was prepared with a silicone polymer, and the extracellular matrix component was supported on the inside of the structure to apply the composition to the cosmetic composition. The crosslinked silicone membrane and the extracellular matrix component secures the breathability of the skin and prevents the loss of moisture in the skin And not only has excellent moisturizing effect, but also is excellent in the effect of improving the skin texture due to the skin cosmetic ingredients contained in the cosmetic composition.

≪ Example 1 and Comparative Example 1 >

 To obtain the characteristics of the extracellular matrix-siloxane polymer (skin mimetic), the contents were as shown in Table 1 below.

In a more detailed manufacturing process of the embodiment, a silicone liquid containing an extracellular matrix and a crosslinking catalyst is added to an oil phase portion in which a crosslinked silicone liquid, dimethicone, dimethicone polyol, octylmethoxy cinnamate, After mixing and mixing the mixed solution emulsified in the form of heavy water, the mixture is degassed and cooled to room temperature. The comparative examples were prepared using a conventional warming and emulsifying process.

ingredient Example 1
(weight%) Example 2
(weight%) Comparative Example 1
(weight%) Comparative Example 2
(weight%) Polyvinyl alcohol - - 15.0 15.0 Polyvinylpyrrolidone - - 5.0 5.0 A silicone liquid (Vinyldimethicone) containing a crosslinking catalyst 40 40 - - A silicone liquid (Vinyldimethicone) 50.0 50.0 - - Dimecicone 6cs It is 100 grams. - - Dimethicone copolyol 2.0 2.0 - - Polysorbate 60 - - 2.0 2.0 Phospholipids 0.5 0.5 0.5 0.5 Proteoglycan 0.2 0.2 0.2 0.5 Collagen 0.2 0.2 0.2 0.5 amino acid 0.2 0.2 0.2 0.2 Octylmethoxy cinnamate - 0.25 - 0.25 Purified water 2.0 2.0 Balance

The characteristics of the extracellular matrix-siloxane polymer (skin mimetic) thus formed were confirmed by measuring the moisture evaporation amount and the synergistic effect of ultraviolet absorption.

The amount of evaporation of moisture was measured by evaporating the film with the film of Example 1 and Comparative Example 1 sealed on one side of the container with purified water in a thermostatic chamber at 50 ° C with time.

As a result, in Comparative Example 1, the amount of moisture increase was small in the high temperature storage condition, but in Example 1, the degree of evaporation of water gradually increased with time, and after 30 days, The amount of evaporation was shown, and the ventilation was confirmed through this.

The SPF 290 Analyzer (USA) from Optometrics was used for synergy effect. The light source was a Xenone arc lamp, and the measured wavelength range was 290 to 400 nm. 1.0 ml of each of Comparative Example 2 and Examples 1 and 2 was taken and applied uniformly to a thickness of 0.08 mm using an applicator to prepare a skin primer film. After attaching the skin primer film of Comparative Example 2 and Examples 1 and 2 to the sample holder, the position is changed every two measurements on one plate, and a total of 6 scans are measured. The change in erythema index (PFA) was measured in vitro in Comparative Example 1 and Example 1 and Example 2 containing octylmethoxycinnamate.

As a result, in Example 2, the erythema index (PFA) value was about 5.0 times higher than that in Comparative Example 1 and Example 1, which was about 2.5 times higher than that of Example 1, thereby raising the ultraviolet blocking effect of the UVB region.

≪ Comparative Example 3 and Examples 3 to 5 >

To determine the change in hardness of the cosmetic composition containing the extracellular matrix-siloxane polymer, the content was as shown in Table 2 below.

 In Examples 3 to 5 and Comparative Example 3, the silicon liquid containing the crosslinking catalyst was changed to 5.0 wt.% To 10.0 wt.%, And the silicon liquid containing the crosslinking site was changed to 10.0 wt.% To 20.0 wt. A cosmetic composition was prepared using the emulsification process.

A more detailed manufacturing process is to add butylen glycol, carbs and preservative to water and warm / dissolve at 80 ° C. Separately, an oil phase portion in which a crosslinked silicone liquid, a nonionic surfactant, cetanol, and jojoba oil are dissolved is added to this solution, and emulsified at 80 ° C for 10 minutes. Then, at 60 캜, the extracellular matrix and the silicone fluid in the form of water containing a crosslinking catalyst are mixed and crosslinked, followed by cooling to 45 캜. Separately, cosmetic ingredients, fragrance and triethanolamine are added, followed by degassing and cooling to room temperature.

ingredient Comparative Example 3
(weight%) Example 3
(weight%) Example 4
(weight%) Example 5
(weight%) A silicone liquid (Vinyldimethicone) containing a crosslinking catalyst - 5.0 7.5 10.0 A silicone liquid (Vinyldimethicone) - 10.0 15.0 20.0 Dimecicone 6cs 5.0 5.0 5.0 - Dimethicone copolyol 2.0 2.0 5.0 - Polysorbate 60 2.0 2.0 2.0 2.0 Phospholipids 0.5 0.5 0.5 0.5 Proteoglycan 0.2 0.2 0.2 0.5 Collagen 0.2 0.2 0.2 0.5 amino acid 0.2 0.2 0.2 0.2 Butylene glycol 5.0 5.0 5.0 5.0 Preservative 0.5 0.5 0.5 0.5 Jojoba oil 10.0 10.0 10.0 10.0 Cyclomethicone 4.0 4.0 4.0 4.0 Sorbitan olite 2.0 2.0 2.0 2.0 Glyceryl stearate / PEG 100 stearate 2.0 2.0 2.0 2.0 Cetanol 3.0 3.0 3.0 3.0 Carbomer 0.10 0.10 0.10 0.10 Triethanolamine 0.10 0.10 0.10 0.10 Spices 0.10 0.10 0.10 0.10 Purified water Balance

Evaluation items Comparative Example 3 Example 3 Example 4 Example 5 Viscosity (cps) 14,500 16,000 20,000 36,500 Gel strength (elastic force) 14 43 55 96 Appearance Solid cream Solid cream Solid cream Solid Cream Gel

Evaluation items Comparative Example 3 Example 3 Example 4 Example 5 Period (Week) 4 8 12 4 8 12 4 8 12 4 8 12 Viscosity (cps) 14,500 14,600 14,700 16,000 16,200 16,500 20,800 20,500 21,000 36,500 36,800 37,100 Gel strength (elastic force) 14 14 14 43 44 45 55 67 76 96 105 109

The state of the cosmetic composition was confirmed by measuring the viscosity and the elasticity (crushing strength and shear stress) of the gel.

The viscosity was measured using Brooksfield RVP viscometer E and the gel strength was measured at room temperature using Instron 5569 (Instron co., USA). The thickness of the specimen was 5.0 mm and the diameter was 10 mm. Three specimens were prepared for each specimen. The cross head speed was 10 mm / min when measured, and the compressive strength was measured when the specimen was subjected to 50% deformation.

As a result, in Comparative Example 3 in which the extracellular matrix-siloxane polymer (skin mimetic) was not included, the viscosity was the lowest and the gel strength was the lowest. However, in Examples 3 to 5, the elastic force was gradually increased, Respectively. In the case of Example 5, the viscosity and the elasticity were rapidly increased, showing a flow characteristic close to that of a solid gel rather than a solid cream type.

≪ Comparative Example 4 and Examples 6 to 8 >

Experiments of the following examples and comparative examples were carried out in order to examine the influence of the viscosity and the elasticity (gel breakage strength, shear stress) of the rheology modifier.

In Examples 6 to 8 and Comparative Example 4, the silicone composition was kept at 5.0 wt% and 10.0 wt%, respectively, and lipophilic acid was changed to 0.1 to 0.4 wt% .

A more detailed manufacturing process involves adding butylen glycol, carbohydrates, lipoic acid, and preservative to water and heating / dissolving at 80 ° C. Separately, an oil phase portion in which a crosslinked silicone liquid, a nonionic surfactant, cetanol, and jojoba oil are dissolved is added to this solution, and emulsified at 80 ° C for 10 minutes. Then, at 60 캜, the extracellular matrix and the silicone fluid in the form of water containing a crosslinking catalyst are mixed and crosslinked, followed by cooling to 45 캜. Separately, cosmetic ingredients, fragrance and triethanolamine are added, followed by degassing and cooling to room temperature.

ingredient Comparative Example 4
(weight%) Example 6
(weight%) Example 7
(weight%) Example 8
(weight%) A silicone liquid (Vinyldimethicone) containing a crosslinking catalyst 5.0 5.0 5.0 5.0 A silicone liquid (Vinyldimethicone) 10.0 10.0 10.0 10.0 Dimecicone 6cs 5.0 5.0 5.0 5.0 Dimethicone copolyol 2.0 2.0 5.0 5.0 Polysorbate 60 2.0 2.0 2.0 2.0 Phospholipids 0.5 0.5 0.5 0.5 Proteoglycan 0.2 0.2 0.2 0.5 Collagen 0.2 0.2 0.2 0.5 amino acid 0.2 0.2 0.2 0.2 Butylene glycol 5.0 5.0 5.0 5.0 Preservative 0.50 0.50 0.50 0.50 Jojoba oil 10.0 10.0 10.0 10.0 Cyclomethicone 4.0 4.0 4.0 4.0 Sorbitan olite 2.0 2.0 2.0 2.0 Glyceryl stearate / PEG 100 stearate 2.0 2.0 2.0 2.0 Cetanol 3.0 3.0 3.0 3.0 Carbomer 0.10 0.10 0.10 0.10 Triethanolamine 0.10 0.10 0.10 0.10 Spices 0.10 0.10 0.10 0.10 Lipoic acid - 0.1 0.2 0.4 Purified water Balance

Evaluation items Comparative Example 4 Example 6 Example 7 Example 8 Viscosity (cps) 16,000 15,500 16,800 16,500 Gel strength (elastic force) 43 40 45 21 Appearance Solid cream Solid cream Solid cream Solid cream

Evaluation items Comparative Example 4 Example 6 Example 7 Example 8 Period (Week) 4 8 12 4 8 12 4 8 12 4 8 12 Viscosity (cps) 16,000 16,700 17,000 15,500 15,800 16,000 16,800 17,000 17,200 16,500 16,800 17,100 Gel strength (elastic force) 43 42 40 40 41 40 45 47 46 21 15 9

The state of the cosmetic composition was confirmed by measuring the viscosity and the elasticity (crushing strength and shear stress) of the gel.

The viscosity was measured using Brooksfield RVP viscometer E and the gel strength was measured at room temperature using Instron 5569 (Instron co., USA). The thickness of the specimen was 5.0 mm and the diameter was 10 mm. Three specimens were prepared for each specimen. The cross head speed was 10 mm / min when measured, and the compressive strength was measured when the specimen was subjected to 50% deformation.

As a result, in Comparative Example 4 in which lipoic acid was not contained and in Examples 6 to 8 in which lipoic acid was contained, the viscosity and gel strength were similar, but in Example 8, the elastic force was drastically decreased and the flow characteristics of the pseudo-plastic gel were weak It looked.

Example 8 showed the same solid cream phase as that of Comparative Example 4, but the elastic strength of the gel was lowered by about 51%, so that lipoic acid, a rheology modifier, was found in the cosmetic composition of the extracellular matrix-siloxane polymer Flow characteristics.

The rheological retention performance of the cosmetic composition over time also showed that rheological properties of Comparative Example 4 and Examples 6 and 7, which contain 0, 0.1 and 0.2 wt%, respectively, of lipoic acid, have uniform viscosity and gel strength However, in Example 8, the viscosity was constant, but the elasticity was abruptly decreased, so that the flow characteristics of the pseudo-plastic gel were weak and the stable rheological properties were not shown.

≪ Comparative Examples 5 and 10 >

Following the use of the cosmetic composition, the following examples and comparative examples were tested to confirm the formation of extracellular matrix-siloxane polymer (skin mimetic) membrane in the skin.

In Comparative Examples 5 and 10, a cosmetic composition was prepared by using a conventional warming and emulsifying process in which the amounts of silicone solutions were 5.0 wt% and 10.0 wt%, respectively.

A more detailed manufacturing process involves adding butylen glycol, carbohydrates, lipoic acid, and preservative to water and heating / dissolving at 80 ° C. Separately, an oil phase portion in which a crosslinked silicone liquid, a nonionic surfactant, cetanol, and jojoba oil are dissolved is added to this solution, and emulsified at 80 ° C for 10 minutes. Then, at 60 캜, the extracellular matrix and the silicone fluid in the form of water containing a crosslinking catalyst are mixed and crosslinked, followed by cooling to 45 캜. Separately, cosmetic ingredients, fragrance and triethanolamine are added, followed by degassing and cooling to room temperature.

ingredient Comparative Example 5
(weight%) Example 10
(weight%) A silicone liquid (Vinyldimethicone) containing a crosslinking catalyst - 5.0 A silicone liquid (Vinyldimethicone) - 10.0 Dimecicone 6cs - 5.0 Dimethicone copolyol - 5.0 Polysorbate 60 - 2.0 Phospholipids - 0.5 Proteoglycan - 0.2 Collagen - 0.2 amino acid - 0.2 Butylene glycol 5.0 5.0 Preservative 0.50 0.50 Jojoba oil 10.0 10.0 Cyclomethicone 4.0 4.0 Sorbitan olite 2.0 2.0 Glyceryl stearate / PEG 100 stearate 2.0 2.0 Cetanol 3.0 3.0 Carbomer 0.10 0.10 Triethanolamine 0.10 0.10 Spices 0.10 0.10 Lipoic acid - 0.1 Purified water Balance

Evaluation items Comparative Example 5 Example 10 Viscosity (cps) 16,000 15,500 Number of beads attached () 23.5 8.3 Appearance Solid cream Solid cream

Evaluation items Comparative Example 5 Example 10 Period (Week) 4 4 Moisture growth rate (%) 2.16 10.49

Whether or not the film was formed after use of the cosmetic composition was confirmed by bead adhesion test. The emollient oil or wax, which is a constituent component of the cosmetic composition, and the emulsifier component remain on the skin after use and exhibit an adhesive property which facilitates adherence of fine foreign substances such as dust.

The bead adhesion test was carried out at room temperature using beads of spherical plastic material of about 0.05 mm. For measurement, a 5 x 5 cm area was set on the inside of the arm, and about 1.0 mL of the comparative example and the example were applied. After 5 minutes, 40 spherical beads were placed and a small fan was placed in a weak wind (5-6 m / s) , The number of beads remaining on the skin was measured three times repeatedly. The viscosity was measured using a Brookfield RVP viscometer, E-bar.

The moisturizing effect test on the skin was carried out by using a corneometer in a constant temperature and humidity room (25 ° C, relative humidity 60%) for 20 weeks for 20 to 50 year old female subjects using Comparative Example 5 and Example 10 for 4 weeks for 4 weeks, ) Was used to measure the moisture increase rate of the skin.

As a result, in Comparative Example 5 in which the extracellular siloxane extracellular matrix-siloxane polymer (skin simulant) film was not included, only about 41% of the beads were attached to the skin, but in the Example including the extracellular matrix- 10, about 79% were removed and only 19% remained. Thus, it has been confirmed that the extracellular matrix-siloxane polymer (skin mimetic) contained in the cosmetic composition is formed in the form of a thin film on the skin, which interferes with the adhesive properties of cosmetic ingredients left on the skin after use.

As a result of the skin moisturizing test, the moisturizing condition of the skin of Example 10 was improved about 5 times as compared with that of Comparative Example 5 after 4 weeks of using the product.

Claims (15)

An extracellular matrix component comprising proteoglycans, phospholipids and collagen; Rheology modifiers; And a cosmetic composition comprising a siloxane polymer containing a siloxane polymer as an active ingredient. The composition of claim 1 comprising 0.01 to 15.0% by weight of a siloxane polymer, 0.01 to 10.0% by weight of an extracellular matrix component, 0.01 to 1.0% by weight of a rheology modifier, and 1.0 to 30.0% The composition for underwater type cosmetic composition according to claim 1, further comprising 0.1 to 10.0% by weight of emollient oil, 0.01 to 10.0% by weight of wax, 0.01 to 10.0% by weight of emulsifier, 1.0 to 20.0% by weight of polyhydric alcohol, The underwater type cosmetic composition according to claim 1, wherein the siloxane polymer is vinyl dimethicone or a hydrogendimethicone. The method according to claim 1, wherein the extracellular matrix component further comprises at least one member selected from the group consisting of amino acids, saccharide isomerate, and components of tremelapaxiposus polysaccharide. Cosmetic composition. 5. The composition for underwater type cosmetic composition according to claim 4, wherein the amino acid component is at least one selected from the group consisting of serine, glycine, arginine, glutamic acid, tyrosine and alanine. The underwater cosmetic composition according to claim 1, wherein the rheology modifier component is at least one selected from the group consisting of oxides, ceramides, polyacrylamides, lipoic acid, and lipoic acid PEG derivatives. The composition according to claim 1, wherein the skin cosmetic ingredient is selected from the group consisting of adenosine, retinol, arbutin, hyaluronic acid, tocopherol, 7-dihydrocholesterol, march extract, tocopheryl acetate, niacinamide, ascorbic acid, ascorbyl glucoside, and EGCG Wherein the at least one cosmetic composition is at least one selected from the group consisting of water-in-oil type cosmetic compositions. delete The composition for underwater type cosmetic composition according to claim 1, wherein the composition maintains breathability and moisturizing properties when applied to skin. A method for preparing a cosmetic composition comprising a complex of an extracellular matrix and a siloxane polymer comprising the steps of:
(a) emulsifying a mixture of water, wax, rheology control agent, emollient oil and emulsifier in a silicone liquid containing a crosslinking site to obtain a liquid mixture of oil-in-water type;
(b) blending a liquid mixture of silicone fluid in a water-in-oil form containing an extracellular matrix component and a crosslinking catalyst into the mixture of (a); And
(c) mixing a skin cosmetic ingredient with a mixture solution comprising the cross-linked extracellular matrix-siloxane polymer of (a) and (b) to obtain a cosmetic composition of oil-in-water type. 11. The method of manufacturing a cosmetic composition according to claim 10, wherein the silicone liquid containing the crosslinking site is a mixture of vinyl dimethicone, silica, and hydrogendimethicone. 11. The method of manufacturing a cosmetic composition according to claim 10, wherein the silicone liquid in the water-in-oil form containing the crosslinking catalyst is a mixture of vinyl dimethicone, silica, and colloidal platinum. 11. The composition of claim 10, wherein the extracellular matrix component is at least one member selected from the group consisting of proteoglycan, collagen, phospholipids, and components of amino acids, saccharide isomerate, and tremelapaxiposus polysaccharide Gt; 11. The method of claim 10, wherein the rheology modifier component is at least one selected from the group consisting of oxides, ceramides, polyacrylamides, lipoic acid, and lipoic acid PEG derivatives. 11. The composition of claim 10, wherein the skin cosmetic ingredient is selected from the group consisting of adenosine, retinol, arbutin, hyaluronic acid, tocopherol, 7-dihydrocholesterol, march extract, tocopheryl acetate, niacinamide, ascorbic acid, ascorbyl glucoside, and EGCG Wherein the cosmetic composition is at least one kind selected from the group consisting of:

Images