KR101901170B1 - Pharmaceutical composition for preventing or treating of premenstrual syndrome comprising extract of sarcodon asparatus as an ative ingredient - Google Patents

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating premenstrual syndrome comprising a Sarcodon imbricatus extract as an active ingredient. Specifically, the Sarcodon imbricatus extract of the present invention, even if taken only once, eliminates the premenstrual syndrome such as lower abdominal pain, backache, mastodynia, headache, binge, insomnia, lethargy, mood swing or depression and the like, and the above effect is maintained for at least one year. The extract also relieves menstrual pain, reduces the menstrual period, the amount of menstruation, the irregularity of the menstrual period and extravasated blood, and it was also confirmed that the color of the menstruation is clear, thereby being useful for prevention or treatment of the premenstrual syndrome.

Description

TECHNICAL FIELD [0001] The present invention relates to a pharmaceutical composition for prevention or treatment of a premenstrual syndrome containing an extract of Mushroom mushroom as an active ingredient. The present invention relates to a pharmaceutical composition for preventing or treating a premenstrual syndrome,

The present invention relates to a pharmaceutical composition for preventing or treating a premenstrual syndrome which contains an extract of Mushroom mushroom as an active ingredient.

In general, women start menstruation for about 35 years and then have irregular menstrual periods for months to years, along with natural degeneration of ovarian function, and menstrual periods between 45 and 55 years .

Premenstrual syndrome refers to mental, behavioral, and physical symptoms that occur about 7 to 10 days before menstruation and completely disappear or alleviate with the onset of menstruation (Greene R, Dalton K (1953): The premenstrual syndrome syndrome, BMJ 1 (4818): 1007-1014). On the other hand, it is reported that premenstrual syndrome is a more accurate name than premenstrual syndrome because some premenstrual syndrome does not appear before menstruation and still disappears completely during menstruation.

Examples of the symptoms of PMS include instability, mood change, depression, tension, anxiety, fatigue, insomnia, pain, back pain, binge eating, weight gain, breast pain and edema, A total of 200 symptoms have been reported and rarely reported symptoms have been reported (Glass GS, et al., 1971. Psychiatric emergency related Psychiatry, 128, 705-711; Parlee MB, 1976. Primary Care , 3, 477-489; Andersh B and Hahn L. Premenstrual complaints, Influence of oral contraceptives, Acta obstet gynec. Scand., 60, 579-583; Sanders D, et al., 1983)

The mechanism of the premenstrual syndrome is still unclear. Estimated causes include hormonal imbalance (Thys-Jacobs S, Alvir MJ (1995), J Clin Endocrinol Metab 80 (7): 2227-2232), dietary factors such as nutritional deficiency (Lauerson NH (1985) Br J Genes Practice 41 (3): 55-57), imbalance of neurotransmitters (O (1)), and Taylor RJ Brien PM (1993): Helping women with premenstrual syndrome, BMJ 307 (6917): 1471-1475), and is described as a multifactorial neuropsychology-endocrine dysfunction .

About 70-90% of women who are pregnant are known to experience symptoms associated with menstruation, and about 20-75% of all women experience premenstrual syndrome, with 5-10% of them having severe symptoms that affect their lives And the social and economic losses caused by the loss of women's activities are very large.

There are no treatments that fundamentally treat PMS and the most effective way to inhibit the related physical pain is to inhibit the production of prostaglandins by administering aspirin, ibuprofen, acetaminophen, and the like. However, these drugs can cause side effects such as drug resistance, dyspepsia, nausea, vomiting, constipation, diarrhea, headache, dizziness, visual impairment, hearing impairment, sleepiness, fatigue and gastrointestinal bleeding.

Therefore, studies are being actively carried out to develop a substance that alleviates the premenstrual syndrome without side effects. In this connection, a composition for the prevention of menstrual cramping syndrome and dysmenorrhoea of a ginseng fruit extract is disclosed in Korean Patent Laid-open Publication No. 10-2015-005430, and the use of aceclofenac and scopolamine for dysmenorrhoea pain relief or treatment is disclosed in Korean Patent Registration No. 10-1598283 Lt; / RTI >

On the other hand, mushrooms have been widely used for food and medicine for thousands of years. Mushrooms contain polysaccharides, polysaccharide-peptide complexes, triterpenoids, and proteins, which are metabolites, There is an important pharmacological value in that it has.

These mushroom Sarcodon Asparatus is a mushroom belonging to thephyllophorales of thephyllophorales (Thelphoraceae). The fruiting bodies are 10 to 20 cm in height, funnel-shaped like a morning glory, and many A spit is sprouting. The umbrella has a diameter of 7 to 25 cm and a height of 7 to 25 cm. The surface is rough and has large scales on its surface. Dried mushroom is said to be a so called mushroom when it dries and strong fragrance comes out.

The mushroom is highly effective in regulating biological function and is known to be effective in preventing and improving adult diseases such as cancer, stroke, and heart disease. The mushroom is formed by oak root and exogenous mycorrhiza. It is a mushroom grown on the ground of a deciduous forest or as a newborn mushroom, and has not yet been cultivated.

Accordingly, the inventors of the present invention have found that when extracts of Pseudomonas aeruginosa are used for the relief of the symptoms of PMS and the safe and safe treatment of PMS symptoms, the extracts of Pseudomonas mushroom may be used for the treatment of lower abdominal pain, back pain, mastectomy, headache, binge, insomnia, Emotional relief or depression, and the effect lasts from 4 to 12 months, alleviating dysmenorrhoea, decreasing the amount of menstrual period, amount of menstruation, decreasing menstrual irregularity and eosinophilia, and clearing the color of menstruation By confirming, the present invention has been completed.

It is an object of the present invention to provide a preventive or therapeutic use of PYM syndrome.

In order to achieve the above object, the present invention provides a pharmaceutical composition for preventing or treating PMS, which comprises an extract of Mushroom mushroom as an active ingredient.

The present invention also provides a health functional food for improving the premenstrual syndrome, comprising the extract of Mushroom mushroom as an active ingredient.

The mushroom extract of the present invention eliminates the symptoms of premenstrual syndrome such as lower abdominal pain, back pain, mastectomy, headache, binge eating, insomnia, insomnia, emotional upset or depression even when taken once, And can be useful for prevention or treatment of premenstrual syndrome by alleviating menstrual pain, reducing menstrual period, amount of menstruation, decreasing menstrual irregularity and eosinophilia, and clearing the color of menstruation.

Hereinafter, the present invention will be described in detail.

The present invention provides a pharmaceutical composition for preventing or treating PMS, which comprises an extract of Mushroom mushroom as an active ingredient.

1) extracting the mushroom with an extraction solvent; 2) secondary extraction of the first extract of step 1); 3) filtering the extract of step 2); And 4) concentrating the filtered extract obtained in step 3) under reduced pressure and then drying to prepare an extract of Mushroom mushroom.

In the above method, the mushroom of step 1) can be used without limitation such as cultivated or commercially available, and the fruiting body or mycelium part of the mushroom can be used. In one embodiment of the present invention, the mushroom extract may be extracted from fruiting bodies.

In this method, the extraction solvent of step 1) may be water, alcohol or a mixture thereof. The alcohol may specifically be a C ₁ to C ₄ lower alcohol, more specifically, methanol or ethanol. In one embodiment of the present invention, the extraction solvent may be water. As the extraction method, any conventional method known in the art can be used such as extraction under reduced pressure, hot water extraction, filtration, hot water extraction, immersion extraction, reflux extraction, cold extraction, steam extraction, room temperature extraction or ultrasonic extraction. In one embodiment of the present invention, the extraction method may be hot water extraction. The extraction solvent may be added in an amount of 30 to 90 times, specifically 40 to 80 times, more specifically 50 to 70 times, based on the dry weight of the active mushroom. In one embodiment of the present invention, the extraction solvent may be added in an amount of 60 times based on the dry weight of the active mushroom.

The primary extraction of step 1) above may be carried out at 30 ° C to 100 ° C, specifically 40 ° C to 80 ° C, more specifically 45 ° C to 60 ° C. In one embodiment of the present invention, the primary extraction may be performed at 50 < 0 > C. In addition, the primary extraction may be carried out for 5 minutes to 1 hour, specifically 15 minutes to 40 minutes, more specifically 25 minutes to 35 minutes. In one embodiment of the invention, the primary extraction can be carried out for 30 minutes.

The secondary extraction of step 2) may be carried out at 50 ° C to 120 ° C, specifically 70 ° C to 110 ° C, more specifically 90 ° C to 105 ° C. In one embodiment of the present invention, the secondary extraction may be performed at 100 < 0 > C. Further, the secondary extraction may be performed for 5 minutes to 30 minutes, specifically 5 minutes to 20 minutes, more specifically 5 minutes to 15 minutes. In one embodiment of the present invention, the secondary extraction can be performed for 10 minutes.

In addition, the premenstrual syndrome may be due to a female hormone imbalance.

In a specific embodiment of the present invention, the inventors of the present invention have found that when water is added to dried mushroom fruiting body by hot-air drying to prepare a mushroom extract, and the mushroom extract is usually used, I took it to the women who should take it. As a result, even after taking the mushroom extract once, all the women have disappeared such as lower back pain, back pain, masturbation, headache, binge eating, insomnia, lethargy, emotional upset or depression which are symptoms of premenstrual syndrome, Lasted from 4 to 12 months (see Table 1). Also, as a result of taking the above-mentioned extract of the mushroom mushroom for women having severe dysmenorrhea, menstrual cramps disappeared immediately after taking the dose, and the amount of menstruation and menstruation decreased in one month. In addition, the color of the menstruation was clear and the eosinophils disappeared (see Table 2). In addition, the menstrual cramps did not appear or appear less, the amount of menstrual decreased, and the ejaculation disappeared without taking the mushroom extract at the first month of menstruation the next month. This effect continued after 12 months (see Tables 3 to 5).

Therefore, the above-described extract of the mushroom extract may be useful as a pharmaceutical composition for preventing or treating PMS.

The pharmaceutical composition may contain 10 to 95% by weight of the extract of the active ingredient of the present invention, which is an active ingredient, based on the total weight of the pharmaceutical composition. In addition, the pharmaceutical composition of the present invention may further contain at least one active ingredient which exhibits the same or similar functions in addition to the above-mentioned effective ingredients.

Compositions of the present invention may also include carriers, diluents, excipients, or a combination of two or more thereof commonly used in biological formulations. The pharmaceutically acceptable carrier is not particularly limited as long as it is suitable for delivering the composition in vivo. Examples include Merck Index, 13th ed., Merck & Inc. Sterilized water, Ringer's solution, buffered saline, dextrose solution, maltodextrin solution, glycerol, ethanol, or a mixture of at least one of these components. At this time, other conventional additives such as an antioxidant, a buffer, a bacteriostatic agent and the like may be added as necessary.

When the composition is formulated, it is prepared using diluents or excipients such as fillers, extenders, binders, humectants, disintegrants, surfactants and the like which are usually used.

The composition of the present invention may be formulated as an oral preparation or a parenteral preparation. Solid formulations for oral administration include tablets, pills, powders, granules, capsules, troches and the like, which may contain one or more excipients such as starch, calcium carbonate, sucrose, Lactose, gelatin, and the like. Lubricants such as magnesium stearate and talc may also be added. On the other hand, liquid formulations include suspensions, solutions, emulsions or syrups, which may contain excipients such as wetting agents, sweeteners, fragrances, preservatives and the like.

Formulations for parenteral administration may include injections such as sterile aqueous solutions, non-aqueous solutions, suspensions, and emulsions.

Examples of the non-aqueous solvent and suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like.

The composition of the present invention may be administered orally or parenterally in accordance with the desired method, and parenteral administration may be carried out by external or intraperitoneal injection, rectal injection, subcutaneous injection, intravenous injection, intramuscular injection, ≪ / RTI >

The composition according to the invention is administered in a pharmaceutically effective amount. It may vary depending on the type of disease, severity, activity of the drug, sensitivity to the drug, time of administration, route of administration and rate of excretion, duration of treatment, The composition of the present invention may be administered alone or in combination with other therapeutic agents. When administered concomitantly, the administration can be sequential or simultaneous.

However, for the desired effect, the amount of the active ingredient contained in the pharmaceutical composition according to the present invention may be 0.001 to 10,000 mg / kg, specifically 0.1 to 5 g / kg. The administration may be one time per day and may be divided into several times.

The present invention also provides a health functional food for improving the premenstrual syndrome, comprising the extract of Mushroom mushroom as an active ingredient.

1) extracting the mushroom with an extraction solvent; 2) secondary extraction of the first extract of step 1); 3) filtering the extract of step 2); And 4) concentrating the filtered extract obtained in step 3) under reduced pressure and then drying to prepare an extract of Mushroom mushroom.

In the above method, the mushroom of step 1) can be used without limitation such as cultivated or commercially available, and the fruiting body or mycelium part of the mushroom can be used. In one embodiment of the present invention, the mushroom extract may be extracted from fruiting bodies.

The extract can be extracted using water, alcohol or a mixture thereof as a solvent. The alcohol may specifically be a C ₁ to C ₄ lower alcohol, more specifically, methanol or ethanol. In one embodiment of the present invention, the extraction solvent may be water. In addition, the premenstrual syndrome may be due to a female hormone imbalance.

In a specific embodiment of the present invention, the inventors of the present invention have found that when water is added to dried mushroom fruiting body by hot-air drying to prepare a mushroom extract, and the mushroom extract is usually used, I took it to the women who should take it. As a result, even after taking the mushroom extract once, all the women have disappeared such as lower back pain, back pain, masturbation, headache, binge eating, insomnia, lethargy, emotional upset or depression which are symptoms of premenstrual syndrome, Lasted from 4 to 12 months (see Table 1). Also, as a result of taking the above-mentioned extract of the mushroom mushroom for women having severe dysmenorrhea, menstrual cramps disappeared immediately after taking the dose, and the amount of menstruation and menstruation decreased in one month. In addition, the color of the menstruation was clear and the eosinophils disappeared (see Table 2). In addition, the menstrual cramps did not appear or appear less, the amount of menstrual decreased, and the ejaculation disappeared without taking the mushroom extract at the first month of menstruation the next month. This effect continued after 12 months (see Tables 3 to 5).

Therefore, the above-described extract of the mushroom extract may be useful for improving the premenstrual syndrome.

The content of the mushroom extract, which is an active ingredient added to the health functional food, can be determined depending on the purpose. Generally, the content may be 0.01 to 90 parts by weight of the total weight of the health functional food.

There is no particular limitation on the form and kind of the health functional food. The form of the health functional food to which the substance is added may be a tablet, a capsule, a powder, a granule, a liquid, a ring and the like.

The health functional food of the present invention may contain various flavoring agents or natural carbohydrates as an additional ingredient such as a normal health functional food. The above-mentioned natural carbohydrates are sugar alcohols such as monosaccharides such as glucose and fructose, polysaccharides such as disaccharides such as maltose and sucrose, dextrin and cyclodextrin, and xylitol, sorbitol and erythritol. Examples of sweeteners include natural sweeteners such as tau martin and stevia extract, synthetic sweeteners such as saccharin or aspartame, and the like.

In addition to the above, the health functional food of the present invention may contain various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and salts thereof, alginic acid and its salts, organic acids, protective colloid thickening agents, pH adjusting agents, stabilizers, Alcohol, and the like. These components may be used independently or in combination. The proportion of such additives may be selected in the range of 0.01 to 0.1 parts by weight per 100 parts by weight of the extract of the present invention.

Hereinafter, the present invention will be described in detail by the following examples.

However, the following examples are illustrative of the present invention, and the contents of the present invention are not limited thereto.

<Example 1> Preparation of extract of Mushroom mushroom

Fruiting bodies of the mushrooms collected from the mountains of Andong, Gyeongsangbuk province were dried by hot air in a conventional manner and then pulverized. Thereafter, 3 g of the ground mushroom powder was added to 180 ml of water, boiled at 50 DEG C for 30 minutes, and then boiled at 100 DEG C for 10 minutes to obtain a mushroom extract.

< Experimental Example  1> Mushroom  Extract Monthly scripture  Syndrome treatment efficacy confirmation

The following experiments were carried out to evaluate the efficacy and efficacy of Pseudomonas aeruginosa extract for relieving symptoms of premenstrual syndrome.

<1-1> Subjects to be tested

We evaluated the efficacy and efficacy of antioxidant mushroom extract on the symptoms of premenstrual syndrome in 17 women aged between 10 and 50 who had experience of premenstrual syndrome and had experience of medical treatment or taking painkillers.

<1-2> Mushroom  Before and after taking the extract Monthly scripture  Syndrome treatment efficacy confirmation

In order to confirm changes before and after the administration of the mushroom extract, women who have experienced the usual premenstrual syndrome symptoms or who have experienced the medical treatment of the doctor or who should take the painkiller are selected, and when the premenstrual syndrome is started, Lt; RTI ID = 0.0 &gt; ml &lt; / RTI &gt; As a result, the change with the use of the extract is shown in Table 1 below.

Before and after taking mushroom extract
number
Monthly scripture
syndrome
Period of occurrence
(The prelate of the month)
Before taking
Symptom

After taking
Symptom
Premenstrual syndrome symptoms
Period of occurrence
4 months 6 months 12 months 48 months One 7 days Back pain, masturbation, insomnia none none none none do not know 2 10 days Back pain, breast pain none none none none do not know 3 6 days Back pain, binge none none none do not know do not know 4 10 days Back pain, masturbation, headache, depression none none none none none 5 5 days Back pain, emotional relief none none none none do not know 6 7 days Back pain, masturbation, insomnia none none none none do not know 7 3 days Abdominal pain, back pain, binge eating, depression none none none none do not know 8 7 days Back pain, depression none none none none do not know 9 14 days Back pain, masturbation, insomnia none none none none do not know 10 6 days Lower abdominal pain, back pain, masturbation, emotional relief none none none none do not know 11 10 days Back pain, breast cancer, none none none none do not know 12 11th Abdominal pain, back pain, breast pain, binge eating, insomnia none none none none do not know 13 10 days Back pain, headache, emotional relief none none none none do not know 14 7 days Back pain, binge none none none none do not know 15 2 days Abdominal pain, back pain, breast pain, binge eating, depression none none none none do not know 16 4 days Back pain, masturbation, headache, binge eating, emotional relief none none none none do not know 17 10 days Back pain, masturbation, binge eating, insomnia, insomnia none none none do not know do not know 18 4 days Back pain, masturbation, headache, depression none none do not know do not know do not know 19 7 days Back pain, binge none none do not know do not know do not know 20 10 days Abdominal pain, back pain, breast pain, binge eating, insomnia, depression none none do not know do not know do not know

As shown in Table 1, shortly after taking the mushroom extract, all women suffering from premenstrual syndrome symptoms such as lower back pain, back pain, masturbation, headache, binge eating, insomnia, weakness, emotional relief or depression disappeared. The effect lasted until 4 to 12 months, and the effect continued for 48 months (Table 1).

< Experimental Example  2> Mushroom  Efficacy of Extracts to Treat Dysmenorrhea

<2-1> Mushroom  Efficacy of dysmenorrhea treatment before and after taking extract

Next, in order to confirm the therapeutic efficacy of dysmenorrhoea before and after the administration of the mushroom extract, 17 dysmenorrheic women who should normally take dysmenorrhea are selected and when the dysmenorrhea starts, the extract 160 Ml &lt; / RTI &gt; As a result, the changes with the use of the extract are shown in Table 2 below.

Before and after taking mushroom extract
number Menstrual pain
Period of occurrence Menstrual period Amount of menstruation Color of menstruation Generation of ebony
The presence or absence Menstrual impurity
The presence or absence I'm Immediately I'm after after after after I'm after One 2 days none 5 days 3 days decrease Clear Gone has exist none 2 2 days none 7 days 5 days decrease Clear Gone none none 3 1 day none 7 days 5 days decrease Clear Gone none none 4 2 days none 5 days 5 days No change Clear Gone none none 5 4 days none 7 days 6 days decrease Clear Decrease none none 6 3 days none 6 days 4 days decrease Clear Gone none none 7 3 days none 5 days 5 days decrease No change Gone none none 8 2 days none 6 days 5 days No change Clear Gone none none 9 2 days none 5 days 5 days decrease Clear Gone none none 10 2 days none 5 days 5 days No change Clear Gone none none 11 4 days none 6 days 6 days decrease Clear Gone none none 12 2 days none 5 days 3 days decrease Clear Gone has exist none 13 3 days none 5 days 5 days decrease Clear Decrease none none 14 1 day none 6 days 4 days decrease Clear Gone none none 15 2 days none 7 days 5 days No change Clear Decrease none none 16 3 days none 7 days 5 days No change No change Gone none none 17 2 days none 6 days 4 days decrease Clear Gone has exist none

As shown in Table 2, dysmenorrhoea disappeared in all women immediately after taking the mushroom extract, and in most women, the amount of menstrual period and menstruation decreased in one month after administration of mushroom extract, Cleared, eosinophilic and menstrual impurities disappeared (Table 2). In addition, in some women menstruation, fatigue, and edema were reduced.

<2-2> Mushroom  Check the efficacy of dysmenorrhea treatment after a single dose of extract

The changes after one month, two months, three months, six months, and twelve months after one dose of the extract of Mushroom mushroom were examined and are shown in Tables 3 to 5 below.

Comparison of incidence of dysmenorrhea number
Dysmenorrhea 1 month 2 months 3 months 6 months 12 months One none none none none none 2 5 minutes none none none do not know 3 none none none none none 4 none none none none none 5 A slight pain none none do not know do not know 6 none none none none none 7 none none none none none 8 none none none none none 9 none none none none none 10 none none none none none 11 none none none none none 12 none none none do not know do not know 13 none none none none none 14 none none none none none 15 none none none none none 16 none none none none none 17 none none none none none

Comparison of the amount of menstruation number
Amount of menstruation 1 month 2 months 3 months 6 months 12 months One decrease decrease decrease decrease decrease 2 decrease decrease decrease decrease do not know 3 decrease decrease decrease decrease decrease 4 No change No change No change No change No change 5 decrease decrease decrease do not know do not know 6 decrease decrease decrease decrease decrease 7 decrease decrease decrease decrease decrease 8 No change decrease decrease decrease decrease 9 decrease decrease decrease decrease decrease 10 No change No change No change No change No change 11 decrease decrease decrease decrease decrease 12 decrease decrease decrease do not know do not know 13 decrease decrease decrease decrease decrease 14 decrease decrease decrease decrease decrease 15 No change No change No change No change No change 16 No change No change No change No change No change 17 decrease decrease decrease decrease decrease

Comparison of presence or absence of eosinophil number
Whether or not to produce eosinophils 1 month 2 months 3 months 6 months 12 months One Gone Gone Gone Gone Gone 2 Gone Gone Gone Gone do not know 3 Gone Gone Gone Gone Gone 4 Gone Gone Gone Gone Gone 5 Decrease Decrease Gone do not know do not know 6 Gone Gone Gone Gone Gone 7 Gone Gone Gone Gone Gone 8 Gone Gone Gone Gone Gone 9 Gone Gone Gone Gone Gone 10 Gone Gone Gone Gone Gone 11 Gone Gone Gone Gone Gone 12 Gone Gone Gone do not know do not know 13 Decrease Decrease Gone Gone Gone 14 Gone Gone Gone Gone Gone 15 Decrease Decrease Decrease Gone Gone 16 Gone Gone Gone Gone Gone 17 Gone Gone Gone Gone Gone

As shown in Tables 3 to 5, the menstrual cramps did not appear or show little, the amount of menstrual decreased, and the eosinophils disappeared even after taking the mushroom extract from the next month after taking the mushroom extract once. The effect lasted after 12 months (Tables 3 to 5).

The mushroom extract according to the present invention can be formulated into various forms according to the purpose. The following are illustrative of some formulations containing the active ingredient (s) of the present invention as an active ingredient, but the present invention is not limited thereto.

&Lt; Formulation Example 1 > Preparation of pharmaceutical preparation

<1-1> Preparation of powder

2 g of the mushroom extract according to the present invention

Lactose 1 g

The above components are mixed and filled in airtight bags to prepare powders.

<1-2> Preparation of tablets

100 mg of the mushroom extract of the present invention

Corn starch 100 mg

100 mg of milk

2 mg of magnesium stearate

After mixing the above components, tablets are prepared by tableting according to a conventional method for producing tablets.

&Lt; 1-3 > Preparation of capsules

100 mg of the mushroom extract of the present invention

Corn starch 100 mg

100 mg of milk

2 mg of magnesium stearate

After mixing the above components, they are filled in gelatin capsules according to the conventional preparation method of capsules to prepare capsules.

&Lt; 1-4 >

1 g of the mushroom extract of the present invention

Lactose 1.5 g

Glycerin 1 g

0.5 g of xylitol

After mixing the above components, they are prepared so as to be 4 g per one ring according to a conventional method.

<1-5> Preparation of granules

150 mg of the mushroom extract of the present invention

Soybean extract 50 mg

Glucose 200 mg

Starch 600 mg

After mixing the above components, 100 mg of 30% ethanol is added, and the mixture is dried at 60 캜 to form granules, which are filled in a capsule.

<1-6> Preparation of injections

500 mg of the mushroom extract according to the present invention

Sterile sterilized water for injection

pH adjuster

(2 ml) per ampoule in accordance with the usual injection method.

<1-7> Production of liquid agent

100 mg of the mushroom extract of the present invention

10 g per isomer

5 g mannitol

Purified water quantity

Each component was added and dissolved in purified water according to the usual liquid preparation method, and the lemon flavor was added in an appropriate amount. Then, the above components were mixed, and then purified water was added thereto. The whole was then adjusted to 100 ml with purified water, And sterilized to prepare a liquid.

&Lt; Formulation Example 2 > Preparation of health functional foods

100 mg of the mushroom extract of the present invention

Vitamin mixture quantity

Vitamin A acetate 70 μg

Vitamin E 1.0 mg

Vitamin B1 0.13 mg

0.15 mg of vitamin B2

Vitamin B6 0.5 mg

Vitamin B12 0.2 μg

Vitamin C 10 mg

Biotin 10 μg

Nicotinic acid amide 1.7 mg

Folic acid 50 μg

Calcium pantothenate 0.5 mg

Mineral mixture quantity

1.75 mg of ferrous sulfate

0.82 mg of zinc oxide

Magnesium carbonate 25.3 mg

Potassium monophosphate 15 mg

Secondary calcium phosphate 55 mg

Potassium citrate 90 mg

Calcium carbonate 100 mg

Magnesium chloride 24.8 mg

Although the composition ratio of the above-mentioned vitamin and mineral mixture is comparatively mixed with a component suitable for a health functional food as a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above components may be mixed , Granules may be prepared and used in the manufacture of a health functional food composition according to a conventional method.

Claims (8)

A pharmaceutical composition for preventing or treating a premenstrual syndrome containing an extract of Mushroom mushroom as an active ingredient.
The pharmaceutical composition according to claim 1, wherein the mushroom is a fruiting body.
The pharmaceutical composition for preventing or treating PMS according to claim 1, wherein the mushroom extract is extracted with water, a C ₁ to C ₄ alcohol or a mixed solvent thereof.
The pharmaceutical composition according to claim 3, wherein the C ₁ to C ₄ alcohol is methanol or ethanol.
The pharmaceutical composition according to claim 1, wherein said premenstrual syndrome is caused by an imbalance of female hormone.
A health functional food for the improvement of the premenstrual syndrome containing the mushroom extract as an active ingredient.
The health functional food for improving PMS according to claim 6, wherein the mushroom is a fruit body.
7. The health functional food according to claim 6, wherein said premenstrual syndrome is caused by an imbalance of female hormones.