KR101847375B1 - Dandelion mixed extract composition for improving brain comfort when tasting and uses thereof - Google Patents

Dandelion mixed extract composition for improving brain comfort when tasting and uses thereof Download PDF

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KR101847375B1
KR101847375B1 KR1020170108824A KR20170108824A KR101847375B1 KR 101847375 B1 KR101847375 B1 KR 101847375B1 KR 1020170108824 A KR1020170108824 A KR 1020170108824A KR 20170108824 A KR20170108824 A KR 20170108824A KR 101847375 B1 KR101847375 B1 KR 101847375B1
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dandelion
comfort
mixed extract
lobe
brain
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김성수
김성문
김민주
손하라라잔 칸다사미
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강원대학교산학협력단
(주)백천바이오텍
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/065Microorganisms
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • A23V2200/322Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2300/00Processes
    • A23V2300/14Extraction

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Abstract

The present invention relates to: a Taraxacum platycarpum mixed extract composition for improving brain comfort; health functional food for improving brain comfort including the Taraxacum platycarpum mixed extract composition; a method for producing the Taraxacum platycarpum mixed extract composition having an effect of improving brain comfort; and to a Taraxacum platycarpum mixed extract produced by the method. The Taraxacum platycarpum mixed extract composition of the present invention, when taking the Taraxacum platycarpum mixed extract, induces the increase of relative fast alpha power spectrum (RFA) in the left prefrontal cortex, left frontal lobe, right frontal lobe, middle larynx, right parietal lobe, central parietal lobe and left parietal lobe, and induces the increase of the spectral edge frequency 50% of the alpha spectrum band (ASEF) in the middle prefrontal cortex to increase the brain comfort.

Description

시음시 두뇌의 쾌적성을 증진시키는 민들레 혼합 추출액 조성물 및 이의 용도{Dandelion mixed extract composition for improving brain comfort when tasting and uses thereof}Dandelion mixed extract composition for enhancing the comfort of brain during tasting and its use -

본 발명은 시음시 좌측 전전두엽, 우측 전두엽, 좌측 후두엽, 우측 후두엽, 중앙 후두엽, 우측 두정엽, 중앙 두정엽 및 좌측 두정엽에서 RFA(Relative fast alpha power spectrum)의 증가와 중앙 전전두엽에서 ASEF(Spectral edge frequency 50% of alpha spectrum band)의 증가를 유도하여 두뇌의 쾌적성을 증진시키는 민들레 혼합 추출액 조성물, 상기 민들레 혼합 추출액 조성물을 포함하는 두뇌 쾌적성 증진용 건강기능식품, 두뇌 쾌적 증진 효과를 지니는 민들레 혼합 추출액의 제조방법 및 상기 방법으로 제조된 민들레 혼합 추출액에 관한 것이다.
The present invention is based on an increase in RFA (relative fast alpha power spectrum) and an increase in ASEF (spectral edge frequency 50%) in the middle prefrontal cortex in the left prefrontal cortex, right frontal cortex, left frontal lobe, right frontal lobe, medial parietal lobe, of alpha spectrum band in order to enhance the comfort of the brain, a health functional food for enhancing brain comfort, which comprises the above-mentioned dandelion mixed extract composition, and a dandelion mixed extract having brain-improving effect And a dandelion mixed extract prepared by the above method.

민들레는 국화과(Compositae)에 속하는 다년생 식물로 우리나라 전역에는 식용가능한 좀민들레(Taraxacum hallanisanese), 산민들레(T. ohwianum), 흰민들레(T. coreanum), 서양민들레(T. officinale), 토종민들레(T. mongolicum)가 서식하고 있다(이, 1996).Dandelion is a perennial plant belonging to the family Asteraceae (Compositae). It is a perennial plant belonging to the family Asteraceae ( Taraxacum hallanisanese ), mountain dandelion ( T. ohwianum ), white dandelion ( T. coreanum ), T. officinale , T. mongolicum ) is inhabited (Lee, 1996).

우리나라에서 민들레는 다양하게 활용되고 있는데 어린잎은 나물로, 뿌리는 약용으로 사용되고 있다. 한방에서는 민들레 뿌리를 포공영, 포공초, 금잠로, 지정이라 하여 종기, 결핵, 해열, 최유, 황달, 간질 치료에 사용하고 있으며, 유럽에서는 변비, 류마티스, 노이로제, 야맹증 예방과 치료에 그리고 북미에서는 커피 대용품으로 사용하고 있다.Dandelion is widely used in Korea. Young leaves are used as herbs, and roots are used as medicines. It is used in the treatment of constipation, rheumatism, neurosis, and blindness in Europe, and in Europe, in the treatment of constipation, tuberculosis, epilepsy, It is used as a substitute.

민들레 잎은 비타민과 무기질이 풍부하고, 지방함량과 칼로리가 낮아 식품영양학적으로 뛰어난 웰빙 식품으로 적당하며, 고미성분인 타락신(taraxcin), 이눌린(inulin)이 많고, 카로티노이드(carotenoid) 성분인 타락사신(taraxathin), 트리터펜(triterpene)인 타락세롤(taraxerol), 타락사스테롤(taraxasterol), β-시토스테롤(β-sitosterol), 그리고 카페인산(caffeic acid) 등과 비타민 A, 비타민 C, 토코페롤(tocopherol), 칼슘(Ca), 철(Fe), 칼륨(K) 등이 풍부하다.The dandelion leaves are rich in vitamins and minerals, low in fat content and calories, suitable for nutritionally good well-being foods, and contain a lot of taraxin, inulin, and carotenoid, Taraxathin, triterpene taraxerol, taraxasterol, β-sitosterol, and caffeic acid, as well as vitamin A, vitamin C, tocopherol, ), Calcium (Ca), iron (Fe), and potassium (K).

민들레에 함유되어 있는 고미성분인 타락사신은 소화촉진 및 간기능향상 효과가 있으며(Kim. 1997. Studies on the steorl and steryl glycoside of dandelion. J. Sangji Univ. 18:409-414), 루테올린은 간기능 증진과 개선효과가 탁월하며(Williams et al. 1996. Flavonoid, cinnamic acids and coumarins from the different tissues and medicinal preparation of Taraxacum officinale. Phytochem. 42:121-127), 민들레 에탄올 추출물은 항알러지, 항염증, 항종양, 항암활성이 보고되었다(Ho et al. 1998. Desacetylmartricarin and anti-allegic component from Taraxacum platycarpum. Planta Med. 64:577-578).In this study, we investigated the effects of ginseng root extracts on the growth of dendritic cells, liver function promoting and improving effect is excellent, and (Williams et al 1996. Flavonoid, cinnamic acids and coumarins from the different tissues and medicinal preparation of Taraxacum officinale Phytochem 42:... 121-127), dandelion ethanol extract of anti-allergy, anti- Inflammatory, antitumor, and anticancer activities have been reported (Ho et al., 1998. Desacetylmartricarin and anti-allegic components from Taraxacum platycarpum. Planta Med. 64: 577-578).

최근에는 민들레의 효능을 이용하여 민들레 김치, 민들레 비누, 민들레차, 민들레 향수, 민들레 진액, 민들레 엑기스, 민들레 한과, 민들레 초콜릿, 민들레 찐빵과 같은 다양한 가공상품이 개발되어 판매되고 있다(양구민들레RIS 사업단. 2017. 양구민들레컨버전스산업체계구축사업 최종 보고서).
Recently, a variety of processing products such as dandelion kimchi, dandelion soap, dandelion tea, dandelion fragrance, dandelion extract, dandelion extract, dandelion flower, dandelion chocolate, and dandelion steamed bread have been developed and marketed using the efficacy of dandelion 2017. Yanggu Dandelion Convergence Industry System Project Final Report).

대한민국 등록특허 제10-1193085호에는 민들레 유산균 발효액을 유효성분으로 포함하는 당뇨 또는 당뇨합병증 개선, 예방 또는 치료용 조성물의 제조방법이 기재되어 있으나, 본 발명의 두뇌 쾌적성 증진용 민들레 혼합 추출액 조성물과는 상이하다.Korean Patent Registration No. 10-1193085 discloses a method for preparing a composition for improving, preventing or treating diabetic or diabetic complication, which comprises a fermented broth of Dandelion Lactobacillus as an active ingredient. However, the composition of the present invention for improving brain comfort, . 대한민국 등록특허 제10-1725665호에는 민들레 당절임 추출액의 혼합발효를 통한 기능성 민들레 발효물의 제조방법이 기재되어 있으나, 본 발명에서와 같이 두뇌 쾌적성 증진 용도에 대해서는 기재된 바가 없다.Korean Patent Registration No. 10-1725665 discloses a method for producing a functional dandelion fermented product by mixed fermentation of a pickle extract of dandelion peria, but there is no description of the use for enhancing brain comfort as in the present invention. 대한민국 등록특허 제10-0870241호에는 민들레를 주재로 한 건강보조식품 및 그 제조방법에 대하여 기재되어 있으나, 본 발명의 두뇌 쾌적성 증진용 민들레 혼합 추출액 조성물과는 상이하다.Korean Patent No. 10-0870241 discloses a health supplement food based on dandelion and a manufacturing method thereof, but is different from the mixed dandelion extract composition of the present invention for improving brain comfort. 대한민국 등록특허 제10-1438717호에는 간세포 보호작용을 갖는 민들레 복합식물 발효추출 조성물과 그의 제조방법이 기술되어 있으나, 본 발명에서와 같이 뇌파 EEG를 측정하여 두뇌 쾌적성을 검증한 것은 아니어서 상이하다.Korean Patent No. 10-1438717 discloses a fermented extract composition of a mixed plant of dandelion plants having a hepatocyte protective action and a method for producing the same, but it does not verify brain comfort by measuring EEG of the brain as in the present invention .

본 발명은 상기와 같은 요구에 의해 도출된 것으로서, 본 발명자들은 민들레 혼합 추출액 조성물을 이용하여 뇌파 변화를 분석한 결과, 본 발명의 민들레 혼합 추출액 조성물은 좌측 전전두엽, 우측 전두엽, 좌측 후두엽, 우측 후두엽, 중앙 후두엽, 우측 두정엽, 중앙 두정엽 및 좌측 두정엽에서 RFA(Relative fast alpha power spectrum)의 증가를, 중앙 전전두엽에서 ASEF(Spectral edge frequency 50% of alpha spectrum band)의 증가를 유도하는 것을 확인함으로써, 본 발명을 완성하였다.
As a result of analyzing EEG changes using the dandelion mixed extract composition, the present inventors have found that the dandelion mixed extract composition of the present invention can be applied to the left frontal lobe, the right frontal lobe, the left larynx, By confirming the increase of RFA (relative fast alpha power spectrum) in the central occipital lobe, right parietal lobe, central parietal lobe and left parietal lobe and increase of ASEF (spectral edge frequency 50% of alpha spectrum band) .

상기 과제를 해결하기 위해, 본 발명은 발효 민들레 추출액, 대추 농축액 및 당귀 농축액을 혼합한 혼합물을 유효성분으로 함유하는 두뇌 쾌적성 증진용 민들레 혼합 추출액 조성물을 제공한다.In order to solve the above problems, the present invention provides a mixed extract composition of dandelion for improving brain comfort comprising a mixture of fermented dandelion extract, jujube concentrate and Angelica giganteum concentrate as an active ingredient.

또한, 본 발명은 상기 민들레 혼합 추출액 조성물을 포함하는 두뇌 쾌적성 증진용 건강기능식품을 제공한다.In addition, the present invention provides a health functional food for enhancing brain comfort comprising the above-described mixed extract composition of dandelion.

또한, 본 발명은 (a) 민들레 분말, 프락토올리고당 분말 및 아스퍼질러스 오리재(Aspergillus oryzae) 균주를 혼합한 후 물을 첨가하여 발효한 발효물에 물을 첨가한 후 추출하여 발효 민들레 추출액을 제조하는 단계; 및 (b) 상기 (a)단계의 제조한 발효 민들레 추출액과 대추 농축액 및 당귀 농축액을 혼합하는 단계를 포함하는 두뇌 쾌적 증진 효과를 지니는 민들레 혼합 추출액의 제조방법을 제공한다.The present invention also relates to a composition comprising (a) a dandelion powder, a fructooligosaccharide powder and an Aspergillus oryzae ), adding water thereto, adding water to the fermented fermented product, and extracting the fermented product to prepare a fermented dandelion extract; And (b) mixing the fermented dandelion extract prepared in step (a) with a jujube concentrate and a Ganoderma concentrate to prepare a mixed extract of dandelion having a brain-cooling enhancing effect.

또한, 본 발명은 상기 방법으로 제조된 두뇌 쾌적 증진 효과를 지니는 민들레 혼합 추출액을 제공한다.
The present invention also provides a mixed extract of dandelion having the brain-comfort enhancing effect prepared by the above-described method.

본 발명의 민들레 혼합 추출액 조성물은 민들레 혼합 추출액 섭취를 통해, 좌측 전전두엽, 우측 전두엽, 좌측 후두엽, 우측 후두엽, 중앙 후두엽, 우측 두정엽, 중앙 두정엽 및 좌측 두정엽에서 RFA(Relative fast alpha power spectrum)의 증가를 유도하고, 중앙 전전두엽에서 ASEF(Spectral edge frequency 50% of alpha spectrum band)의 증가를 유도하여 두뇌 쾌적 증진 효과를 얻을 수 있다. 또한, 본 발명의 민들레 혼합 추출액 조성물을 식품에 첨가하여 두뇌 쾌적 증진 효과를 유도하는 건강기능식품의 개발에 사용될 수 있다.
The mixed extract composition of dandelion of the present invention showed an increase in relative fast alpha power spectrum (RFA) in the left prefrontal cortex, the right frontal lobe, the left occipital lobe, the right occipital lobe, the central occipital lobe, the central parietal lobe and the left parietal lobe (ASEF) in the central pharyngeal lobe, and the brain enhancement effect can be obtained by inducing an increase in the ASEF (spectral edge frequency 50% of the alpha spectrum band). In addition, the present invention can be used for the development of a health functional food which induces a brain-comfort enhancing effect by adding a dandelion mixed extract composition to a food.

도 1은 뇌파 측정을 위해 인간의 두뇌에 전극을 붙이는 부위를 제시한 10-20 국제표준 전극부착법을 보여주는 사진이다.
도 2는 피험자의 두뇌에 EGG용 모자를 씌우고 뇌파를 측정하는 모습을 보여주는 사진이다.
도 3은 물 시음(좌측)과 민들레 혼합 추출액 시음(우측) 후 RFA(Relative fast alpha power spectrum) 변화를 보여주는 뇌지도 맵핑 결과이다.
도 4는 물 시음(좌측)과 민들레 혼합 추출액 시음(우측) 후 ASEF(Spectral edge frequency 50% of alpha spectrum band) 변화를 보여주는 뇌지도 맵핑 결과이다.
FIG. 1 is a photograph showing a 10-20 international standard electrode attaching method showing a region where an electrode is attached to a human brain for EEG measurement.
FIG. 2 is a photograph showing an EGG cap placed on a subject's brain and measuring brain waves.
FIG. 3 shows a brain map mapping result showing changes in RFA (relative fast alpha power spectrum) after a water tasting (left) and a tasting of dandelion mixed extract (right).
FIG. 4 is a map of the brain map showing changes in the ASEF (spectral edge frequency 50% of the alpha spectrum band) after the water tasting (left) and tasting of the dandelion mixed extract (right).

본 발명의 목적을 달성하기 위하여, 본 발명은 발효 민들레 추출액, 대추 농축액 및 당귀 농축액을 혼합한 혼합물을 유효성분으로 함유하는 두뇌 쾌적성 증진용 민들레 혼합 추출액 조성물을 제공한다.In order to achieve the object of the present invention, the present invention provides a mixed extract composition of dandelion for improving brain comfort comprising a mixture of a fermented dandelion extract, a jujube concentrate and a ginseng concentrate as an active ingredient.

본 발명의 두뇌 쾌적성 증진용 민들레 혼합 추출액 조성물에서, 상기 혼합물은 구체적으로는 민들레 분말, 프락토올리고당 분말 및 아스퍼질러스 오리재(Aspergillus oryzae) 균주를 94~96:4~6:0.08~0.12 중량비율로 혼합한 후 물을 첨가하여 30~45℃에서 48~72시간 동안 발효한 발효물에 물을 발효물 대비 5~20배(v/w) 첨가하여 95~100℃에서 8~16시간 동안 추출한 발효 민들레 추출액 94~96 중량%, 대추 농축액 2~4 중량% 및 당귀 농축액 1.5~2.5 중량%를 혼합한 혼합물일 수 있으며, 더욱 구체적으로는 민들레 분말, 프락토올리고당 분말 및 아스퍼질러스 오리재(Aspergillus oryzae) 균주를 95:4.9:0.1 중량비율로 혼합한 후 물을 첨가하여 37℃에서 48~72시간 동안 발효한 발효물에 물을 발효물 대비 10배(v/w) 첨가하여 97℃에서 12시간 동안 추출한 발효 민들레 추출액 95 중량%, 대추 농축액 3 중량% 및 당귀 농축액 2 중량%를 혼합한 혼합물일 수 있다.In the dandelion mixed extract composition for enhancing brain comfort of the present invention, the mixture is preferably a dandelion powder, a fructooligosaccharide powder and an Aspergillus oryzae were mixed at 94 ~ 96: 4 ~ 6: 0.08 ~ 0.12 weight ratio, water was added and the fermented product was fermented at 30 ~ 45 ℃ for 48 ~ 72 hours. , a mixture of 94 to 96% by weight of fermented dandelion extract extracted at 95 to 100 ° C for 8 to 16 hours, 2 to 4% by weight of a jujube concentrate and 1.5 to 2.5% by weight of a concentrate of Angelica keiskei koidz. Specifically, dandelion powder, fructo-oligosaccharide powder, and Aspergillus oryzae were mixed at a weight ratio of 95: 4.9: 0.1, water was added, and water was added 10 times (v / w) to the fermented product fermented at 37 ° C for 48 to 72 hours, 95% by weight of fermented dandelion extract, 3% by weight of jujube concentrate, and 2% by weight of Angelica gigas Lacticum concentrate.

본 발명의 민들레 혼합 추출액 조성물은 좌측 전전두엽, 우측 전두엽, 좌측 후두엽, 우측 후두엽, 중앙 후두엽, 우측 두정엽, 중앙 두정엽 및 좌측 두정엽에서 RFA(Relative fast alpha power spectrum)의 증가를, 중앙 전전두엽에서 ASEF(Spectral edge frequency 50% of alpha spectrum band)의 증가를 유도하여 두뇌 쾌적 증진 효과를 나타내는 것을 특징으로 한다.The mixed extract composition of dandelion according to the present invention has an increase in relative fast alpha power spectrum (RFA) in the left prefrontal region, a right frontal lobe, a left frontal lobe, a right frontal lobe, a middle laryngeal lobe, edge frequency 50% of the alpha spectrum band), thereby exhibiting a brain-comfort enhancing effect.

RFA의 증가는 뇌파 전체에서 빠른 알파파(fast alpha wave)의 비율이 증가하는 것을 의미한다. 빠른 알파파가 증가하면 뇌를 각성시켜 집중력을 향상시키면서도 안정감과 편안함을 느낄 수 있는 상태가 된다. ASEF는 Alpha파의 SEF50를 의미하며, ASEF의 증가는 Fast Alpha파의 비율이 증가했다는 것을 의미하며, 쾌적성 수준을 평가할 때 사용된다.The increase in RFA means that the ratio of fast alpha waves increases in the entire EEG. As the rapid increase in ALPA increases the concentration of the brain by awakening the brain, you can feel the sense of stability and comfort. ASEF means Alpha wave SEF50, and the increase in ASEF means that the rate of Fast Alpha wave increases, and it is used to evaluate comfort level.

또한, 본 발명은 상기 민들레 혼합 추출액 조성물을 포함하는 두뇌 쾌적성 증진용 건강기능식품을 제공한다.In addition, the present invention provides a health functional food for enhancing brain comfort comprising the above-described mixed extract composition of dandelion.

상기 건강기능식품은 여러 가지 영양제, 비타민, 광물(전해질), 합성 및 천연 풍미제, 착색제 및 증진제(치즈, 초콜릿 등), 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산음료에 사용되는 탄산화제 등을 함유할 수 있다. 그 밖에 천연 과일 주스 및 야채 음료의 제조를 위한 과육을 함유할 수 있다. 이러한 성분은 독립적으로 또는 조합하여 사용할 수 있다. The health functional food may contain various nutrients, vitamins, minerals (electrolytes), synthetic and natural flavors, colorants and enhancers (cheese, chocolate etc.), pectic acid and its salts, alginic acid and its salts, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonating agents used in carbonated drinks, and the like. It may also contain flesh for the production of natural fruit juices and vegetable drinks. These components may be used independently or in combination.

본 발명의 건강기능식품은 여러가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다. 상기 천연 탄수화물은 포도당, 과당과 같은 모노사카라이드, 말토스, 슈크로스와 같은 디사카라이드, 및 덱스트린, 사이클로덱스트린과 같은 폴리사카라이드, 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 감미제로서는 타우마틴, 스테비아 추출물과 같은 천연 감미제나, 사카린, 아스파르탐과 같은 합성 감미제 등을 사용할 수 있다.The health functional food of the present invention may contain various flavors or natural carbohydrates as an additional ingredient. The natural carbohydrates are sugar saccharides such as monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as dextrin and cyclodextrin, xylitol, sorbitol and erythritol. Examples of sweeteners include natural sweeteners such as tau martin and stevia extract, synthetic sweeteners such as saccharin and aspartame, and the like.

본 발명은 또한,The present invention also relates to

(a) 민들레 분말, 프락토올리고당 분말 및 아스퍼질러스 오리재(Aspergillus oryzae) 균주를 94~96:4~6:0.08~0.12 중량비율로 혼합한 후 물을 첨가하여 30~45℃에서 48~72시간 동안 발효한 발효물에 물을 발효물 대비 5~20배(v/w) 첨가하여 95~100℃에서 8~16시간 동안 추출하여 발효 민들레 추출액을 제조하는 단계; 및(a) Dandelion powder, fructooligosaccharide powder and Aspergillus oryzae strain are mixed in a weight ratio of 94 to 96: 4 to 6: 0.08 to 0.12, water is added, Adding water to the fermented fermented product for 72 hours at a rate of 5 to 20 times (v / w) relative to the fermented product and extracting the fermented dandelion extract at 95 to 100 ° C for 8 to 16 hours; And

(b) 민들레 혼합 추출액 총 중량 기준으로, 상기 (a)단계의 제조한 발효 민들레 추출액 94~96 중량%와 대추 농축액 2~4 중량% 및 당귀 농축액 1.5~2.5 중량%를 혼합하는 단계를 포함하는 두뇌 쾌적 증진 효과를 지니는 민들레 혼합 추출액의 제조방법을 제공한다.(b) mixing 94 to 96% by weight of the fermented dandelion extract prepared in step (a) with 2 to 4% by weight of a jujube concentrate and 1.5 to 2.5% by weight of a ganoderma concentrate, based on the total weight of the dandelion mixed extract liquid A method for producing a dandelion mixed extract having a brain-comfort enhancing effect is provided.

본 발명의 두뇌 쾌적 증진 효과를 지니는 민들레 혼합 추출액의 제조방법은, 보다 구체적으로는The method for producing a dandelion mixed extract having the brain-comfort enhancing effect of the present invention, more specifically,

(a) 민들레 분말, 프락토올리고당 분말 및 아스퍼질러스 오리재(Aspergillus oryzae) 균주를 95:4.9:0.1 중량비율로 혼합한 후 물을 첨가하여 37℃에서 48~72시간 동안 발효한 발효물에 물을 발효물 대비 10배(v/w) 첨가하여 97℃에서 12시간 동안 추출하여 발효 민들레 추출액을 제조하는 단계; 및(a) Dandelion powder, fructooligosaccharide powder and Aspergillus oryzae strain were mixed in a weight ratio of 95: 4.9: 0.1, water was added, and the resulting fermented product was fermented at 37 DEG C for 48 to 72 hours Adding water 10 times (v / w) to the fermented product, and extracting the fermented dandelion extract at 97 ° C for 12 hours; And

(b) 민들레 혼합 추출액 총 중량 기준으로, 상기 (a)단계의 제조한 발효 민들레 추출액 95 중량%와 대추 농축액 3 중량% 및 당귀 농축액 2 중량%를 혼합하는 단계를 포함할 수 있다.(b) mixing the 95% by weight of the fermented dandelion extract prepared in the step (a) with 3% by weight of the jujube concentrate and 2% by weight of the ginseng concentrate, based on the total weight of the mixed dandelion extract solution.

본 발명은 또한, 상기 방법으로 제조된 두뇌 쾌적 증진 효과를 지니는 민들레 혼합 추출액을 제공한다.
The present invention also provides a mixed extract of dandelion having a brain-comfort enhancing effect produced by the above-described method.

이하, 본 발명을 실시예에 의해 상세히 설명한다. 단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 하기 실시예에 한정되는 것은 아니다.
Hereinafter, the present invention will be described in detail with reference to examples. However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.

제조예Manufacturing example 1. 민들레 혼합 추출액 1. Dandelion mixed extract

(a) 청정지역인 강원도 양구에서 재배한 민들레의 줄기 및 뿌리 부위를 수확하여 즉시 세척 및 건조한 후 분말화하여 민들레 분말을 준비하였다.(a) The stem and root parts of the dandelion cultivated in a clean area, Gangwon-do, were harvested and immediately washed, dried and powdered to prepare dandelion powder.

(b) 상기 (a)단계의 준비한 민들레 분말 95 중량%와 프락토올리고당 분말 4.9 중량%를 혼합한 혼합물을 스팀살균기를 이용하여 110℃의 스팀으로 20분 동안 살균하고 40℃ 이하로 냉각한 후, 황국균(Aspergillus oryzae) 0.1 중량%를 혼합한 혼합물에 배양에 적합한 점도(혼합물 대비 10~20%)로 살균수를 첨가하였다. 상기 살균수를 첨가한 혼합물을 37℃ 및 상대습도 60% 이상에서 48~72시간 동안 배양하여 민들레 발효물을 제조하였다. 상기 제조한 민들레 발효물에 물을 10배(v/w) 첨가한 후 97℃에서 압력 1.0~2.0 kgf/cm2로 유지하면서 12시간 동안 추출한 후 여과(5 ㎛ 필터)하여 발효 민들레 추출액을 제조하였다.(b) A mixture of 95% by weight of the dandelion powder prepared in the step (a) and 4.9% by weight of fructooligosaccharide powder was sterilized with steam at 110 ° C for 20 minutes using a steam sterilizer, , Aspergillus oryzae ) in an amount of 0.1% by weight was added with sterilized water at a viscosity (10 to 20% based on the mixture) suitable for culturing. The mixture containing the sterilized water was cultured at 37 DEG C and a relative humidity of 60% or more for 48 to 72 hours to prepare a dandelion fermented product. The fermented dandelion extract was prepared by adding water 10 times (v / w) to the fermented product of dandelion prepared above, then extracting it for 12 hours while maintaining the pressure at 1.0 to 2.0 kgf / cm 2 at 97 ° C, Respectively.

(c) 상기 (b)단계의 제조한 발효 민들레 추출액 95 중량%와 대추 농축액 3 중량% 및 당귀 농축액 2 중량%를 90℃에서 30분 동안 교반하면서 혼합하여 민들레 혼합 추출액을 제조하였다.
(c) 95% by weight of the fermented dandelion extract prepared in the step (b), 3% by weight of the jujube concentrate and 2% by weight of the concentrate were mixed with stirring at 90 ° C for 30 minutes to prepare a mixed dandelion extract.

실시예Example 1. 민들레 혼합 추출액이 뇌파에 미치는 영향 분석 1. Effects of Dandelion Mixture Extract on EEG

민들레 혼합 추출액의 시음이 인간의 뇌 활동에 어떠한 영향을 주었는지를 알고자 뇌파를 측정하였다. 뇌파 측정은 최대한 잡음이 혼입되지 않은 온도 23℃, 습도 50%가 유지되는 32.4 m2 크기의 실험실에서 남, 녀 각각 10명 총 20명의 피험자를 대상으로 수행하였다. 뇌파측정을 위해 사용한 뇌파측정기는 QEEG-64FX 시스템(LXE3208, LAXTHA Inc. 한국)이었으며, 피험자의 뇌파신호 측정은 LAXTHA사의 데이터 수집 장비 및 분석 프로그램(Telescan)을 이용하였다. 피험자들에게 10~20 국제표준전극 부착법을 이용하여 좌측과 우측 전전두엽(Fp1, Fp2, Fpz, Af3, Af4, Afz), 좌측과 우측 전두엽(F3, F4, F7, F8, Fz, Fc1, Fc2, Fc5, Fc6), 좌측과 우측 측두엽(T3, T4, T7, T8, Cp5, Cp6), 좌측과 우측 두정엽(P3, P4, P7, P8, Cp1, Cp2, Cz, Pz), 좌측과 우측 후두엽(O1, O2, Oz) 부분에 부착하고 오른쪽과 왼쪽 귓불에도 각각 그라운드 및 레퍼런스 전극을 부착하였다(도 1 및 2). 피험자가 눈을 감은 상태에서 맹물 시음(무자극)과 민들레 혼합 추출액 시음(유자극)으로 하여 각각 45초씩 측정하였다. We measured the EEG by knowing the influence of the tasting of the dandelion mixed extract on human brain activity. EEG measurements were performed on a total of 20 subjects, 10 of each male and female, in a laboratory of 32.4 m 2 in which the noise was not mixed and the temperature was maintained at 23 ° C and 50% humidity. The brain waves were measured using the QEEG-64FX system (LXE3208, LAXTHA Inc. Korea). The EEG signals of the subjects were measured using LAXTHA's data collection equipment and analysis program (Telescan). The left and right prefrontal cords (Fp1, Fp2, Fpz, Af3, Af4, Afz), left and right frontal lobes (F3, F4, F7, F8, Fz, Fc1, Fc2, Left and right temporal lobes (P3, P4, P7, P8, Cp1, Cp2, Cz, Pz), left and right temporal lobes (T3, T4, T7, T8, Cp5, Cp6) O1, O2, and Oz), and ground and reference electrodes were attached to the right and left earlobes, respectively (FIGS. 1 and 2). Subjects were measured for 45 seconds with a blind tasting (no irritation) and a mixed extract of dandelion (unstimulated) with eyes closed.

민들레 혼합 추출액에 대한 뇌파측정을 통해 얻어진 데이터 처리는 피험자의 뇌파신호 중 대표적인 30초간의 뇌파신호만을 추출하여 뇌파일괄처리 프로그램(batch processing)으로 수행한 후, 통계분석 소프트웨어 프로그램인 SPSS(SPSS 23.0 version)를 이용하여 대응표본 T 검정을 수행하였다.The data processing obtained by EEG measurement on the mixed extract of dandelion extracts only the representative 30-second EEG signals among the EEG signals of the subject and performed by batch processing of brain waves. Then, statistical analysis software program SPSS (SPSS 23.0 version ) Was used to perform a corresponding sample T test.

민들레 혼합 추출액에 대한 데이터 분석을 위한 뇌파 지표의 종류는 표 1에, 그리고 각각의 뇌파 지표의 의미는 표 2에 나타내었다.
Table 1 shows the types of EEG indicators for analyzing data on the mixed dandelion extracts, and Table 2 shows the meanings of the EEG indices.

데이터 분석에 사용된 뇌파 지표의 종류Types of EEG indicators used in data analysis No.No. 분석지표Analysis index 뇌파 분석 지표의 전체 이름Full name of EEG indicator 파장대(Hz)Waveband (Hz) 1One ATAT Absolute Theta Power SpectrumAbsolute Theta Power Spectrum 4~84 to 8 22 AAAA Absolute Alpha Power SpectrumAbsolute Alpha Power Spectrum 8~138-13 33 ABAB Absolute Beta Power SpectrumAbsolute Beta Power Spectrum 13~3013 to 30 44 AGAG Absolute Gamma Power SpectrumAbsolute Gamma Power Spectrum 30~5030 to 50 55 AFAAFA Absolute Fast Alpha Power SpectrumAbsolute Fast Alpha Power Spectrum 11~1311-13 66 ASAASA Absolute Slow Alpha Power SpectrumAbsolute Slow Alpha Power Spectrum 8~118 ~ 11 77 ALBALB Absolute Low Beta Power SpectrumAbsolute Low Beta Power Spectrum 12~1512 to 15 88 AMBAMB Absolute Mid Beta Power SpectrumAbsolute Mid Beta Power Spectrum 15~2015-20 99 AHBAHB Absolute High Beta Power SpectrumAbsolute High Beta Power Spectrum 20~3020 ~ 30 1010 RTRT Relative Theta Power SpectrumRelative Theta Power Spectrum (4~8)/(4~50)(4 to 8) / (4 to 50) 1111 RARA Relative Alpha Power SpectrumRelative Alpha Power Spectrum (8~13)/(4~50)(8 to 13) / (4 to 50) 1212 RBRB Relative Beta Power SpectrumRelative Beta Power Spectrum (13~30)/(4~50)(13 to 30) / (4 to 50) 1313 RGRG Relative Gamma Power SpectrumRelative Gamma Power Spectrum (30~50)/(4~50)(30 to 50) / (4 to 50) 1414 RFARFA Relative Fast Alpha Power SpectrumRelative Fast Alpha Power Spectrum (11~13)/(4~50)(11 to 13) / (4 to 50) 1515 RSARSA Relative Slow Alpha Power SpectrumRelative Slow Alpha Power Spectrum (8~11)/(4~50)(8 to 11) / (4 to 50) 1616 RLBRLB Relative Low Beta Power SpectrumRelative Low Beta Power Spectrum (12~15)/(4~50)(12 to 15) / (4 to 50) 1717 RMBRMB Relative Mid Beta Power SpectrumRelative Mid Beta Power Spectrum (15~20)/(4~50)(15 to 20) / (4 to 50) 1818 RHBRHB Relative High Beta Power SpectrumRelative High Beta Power Spectrum (20~30)/(4~50)(20 to 30) / (4 to 50) 1919 RSTRST Ratio of SMR to ThetaRatio of SMR to Theta (12~15)/(4~8)(12 to 15) / (4 to 8) 2020 RMTRMT Ratio of Mid Beta to ThetaRatio of Mid Beta to Theta (15~20)/(4~8)(15 to 20) / (4 to 8) 2121 RSMTRSMT Ratio of (SMR-Mid Beta) to ThetaRatio of (SMR-Mid Beta) to Theta (12~20)/(4~8)(12 to 20) / (4 to 8) 2222 RAHBRAHB Ratio of Alpha to High BetaRatio of Alpha to High Beta (8~13)/(20~30)(8 to 13) / (20 to 30) 2323 SEF50SEF50 Spectral Edge Frequency 50%Spectral Edge Frequency 50% 4~504 to 50 2424 SEF90SEF 90 Spectral Edge Frequency 90%Spectral Edge Frequency 90% 4~504 to 50 2525 ASEFASEF Spectral Edge Frequency 50% of Alpha Spectrum BandSpectral Edge Frequency 50% of Alpha Spectrum Band 8~138-13

데이터 분석에 사용된 뇌파 지표의 의미Meaning of EEG indices used in data analysis No.No. 분석지표Analysis index 의미meaning 1One ATAT Theta파의 절대파워 (명상, 졸릴때)Absolute power of theta wave (meditation, sleepy) 22 AAAA Alpha파의 절대파워 (이완, 안정)Absolute power of Alpha wave (relaxation, stability) 33 ABAB Beta파의 절대파워 (긴장, 각성, 활성, 인지작용)The absolute power of Beta waves (tension, arousal, activity, cognitive function) 44 AGAG Gamma파의 절대파워 (고도의 인지작용 또는 불안, 흥분)Absolute power of the Gamma wave (highly cognitive or anxious, excited) 55 AFAAFA Fast alpha파의 절대파워 (편안하면서 몰입)Fast alpha Absolute power of wave (comfortable and immersive) 66 ASAASA Slow alpha파의 절대파워 (이완)Absolute power of Slow alpha wave (relaxation) 77 ALBALB Low beta파의 절대파워, SMR파라고도 함 (주의나 경계)Absolute power of the low beta wave, SMR parameter (caution or boundary) 88 AMBAMB Mid beta파의 절대파워 (집중, 주의)Mid beta wave absolute power (concentration, attention) 99 AHBAHB High beta파의 절대파워 (스트레스, 정신부하, 긴장)High beta Absolute power (stress, mental load, tension) 1010 RTRT 전체 중 Theta파의 비율Percentage of theta waves in total 1111 RARA 전체 중 Alpha파의 비율The ratio of Alpha waves in total 1212 RBRB 전체 중 Beta파의 비율The ratio of Beta waves in total 1313 RGRG 전체 중 Gamma파의 비율Percentage of Gamma waves in total 1414 RFARFA 전체에서 Fast Alpha파의 비율The percentage of Fast Alpha waves in total 1515 RSARSA 전체에서 Slow Alpha파의 비율Slow Alpha ratio in all 1616 RLBRLB 전체에서 Low Beta파의 비율The ratio of Low Beta waves in total 1717 RMBRMB 전체에서 Mid Beta파의 비율Percentage of Mid Beta waves in total 1818 RHBRHB 전체에서 High Beta파의 비율The ratio of High Beta waves in total 1919 RSTRST SMR파/Theta파의 비율The ratio of SMR wave / Theta wave 2020 RMTRMT Mid Beta파/Theta파의 비율Mid Beta wave / Theta wave ratio 2121 RSMTRSMT SMR~Mid Beta파/Theta파 (뇌파집중지표)SMR ~ Mid Beta wave / Theta wave (EEG concentration indicator) 2222 RAHBRAHB Alpha파/High Beta파 (안정 및 이완도)Alpha wave / High Beta wave (stable and relaxed) 2323 SEF50SEF50 Median Frequency 뇌 활성도 (뇌파각성)Median Frequency Brain activity (EEG) 2424 SEF90SEF 90 Median Frequency 뇌 활성도 (정신부하, 스트레스)Median Frequency Brain activity (mental stress, stress) 2525 ASEFASEF Alpha파의 SEF50 (쾌적성: Fast Alpha파가 많음)Alpha SEF50 (Comfort: Fast Alpha wave)

본 실시예에서 민들레 혼합 추출액에 대한 뇌파측정 결과, 25개의 뇌파분석 지표 중 RFA(Relative fast alpha power spectrum), ASEF(Spectral edge frequency 50% of alpha spectrum band) 지표에서만 통계학적인 유의성이 있는 것으로 나타났다(p<0.05). 나머지 23개의 파워스펙트럼은 차이가 발견되지 않았기 때문에 본 실시예에서는 기술하지 않았다.
In the present example, EEG data were statistically significant only in 25 EEG (Relative Fast Alpha Power Spectrum) and ASEF (Spectral edge frequency 50% of alpha spectrum band) p < 0.05). The remaining 23 power spectra were not described in this embodiment because no difference was found.

1. RFA(Relative fast alpha power spectrum) 지표1. Relative fast alpha power spectrum (RFA)

RFA 지표는 뇌파 스펙트럼에서 전체 주파수 영역의 절대파워에 대한 fast alpha 대역의 절대파워 비로서 fast alpha파 영역(11~13 Hz)으로 나누어 준 상대 파워 스펙트럼 값을 의미한다. 민들레 혼합 추출액 시음 시 뇌파분석 지표인 RFA 평균값이 통계적으로 유의미하게 증가하였다(p<0.05).The RFA indicator is the relative power spectrum value divided by the fast alpha wave range (11 ~ 13 Hz) as the absolute power ratio of the fast alpha band to the absolute power of the entire frequency domain in the EEG spectrum. The mean value of RFA, which is an indicator of EEG analysis, increased statistically when tasting mixed dandelion extract ( p <0.05).

Figure 112017083226272-pat00001
Figure 112017083226272-pat00001

2. ASEF(Spectral edge frequency 50% of alpha spectrum band) 지표2. ASEF (Spectral edge frequency 50% of alpha spectrum band)

ASEF 지표는 alpha파의 SEF50으로 쾌적성을 나타내는 뇌파지표로 alpha파의 뇌파 활성도를 확인할 수 있다고 알려져 있다. 민들레 혼합 추출액 시음 시 뇌파분석 지표인 ASEF 평균값이 통계적으로 유의미하게 증가하였다(p<0.05).The ASEF index is an alpha wave SEF50, which is known to be an EEG indicator indicating comfort. The mean value of ASEF, which is an indicator of EEG analysis, increased significantly during tasting of dandelion mixed extract ( p <0.05).

Figure 112017083226272-pat00002
Figure 112017083226272-pat00002

상기의 결과들을 토대로, 본 발명의 민들레 혼합 추출액의 섭취를 통해 뇌파의 변화를 유도하여 두뇌 쾌적 증진 효과를 나타낼 수 있음을 알 수 있었다.
Based on the above results, it was found that the intake of the mixed dandelion extract of the present invention induces a change in brain waves, thereby exhibiting a brain comfort enhancing effect.

Claims (7)

민들레 분말, 프락토올리고당 분말 및 아스퍼질러스 오리재(Aspergillus oryzae) 균주를 94~96:4~6:0.08~0.12 중량비율로 혼합한 후 물을 첨가하여 30~45℃에서 48~72시간 동안 발효한 발효물에 물을 발효물 대비 5~20배(v/w) 첨가하여 95~100℃에서 8~16시간 동안 추출한 발효 민들레 추출액 94~96 중량%, 대추 농축액 2~4 중량% 및 당귀 농축액 1.5~2.5 중량%를 혼합한 혼합물을 유효성분으로 함유하며, 좌측 전전두엽, 우측 전두엽, 좌측 후두엽, 우측 후두엽, 중앙 후두엽, 우측 두정엽, 중앙 두정엽 및 좌측 두정엽에서 RFA(Relative fast alpha power spectrum)를 증가시키며, 중앙 전전두엽에서 ASEF(Spectral edge frequency 50% of alpha spectrum band)를 증가시키는 것을 특징으로 하는 두뇌 쾌적성 증진용 민들레 혼합 추출액 조성물.
Dandelion powder, fructooligosaccharide powder and Aspergillus oryzae strain were mixed in a weight ratio of 94 to 96: 4 to 6: 0.08 to 0.12, water was added, and the mixture was stirred at 30 to 45 ° C for 48 to 72 hours 94 to 96% by weight of fermented dandelion extract, 2 to 4% by weight of jujube concentrate, and Angelica keiskei kotatsu (fermented soybean curd) were added to the fermented fermented product at a temperature of 95 to 100 DEG C for 5 to 20 times (v / (Relative fast alpha power spectrum) in the left prefrontal cortex, the right frontal cortex, the left temporal lobe, the right temporal lobe, the central occipital lobe, the right parietal lobe, the central parietal lobe, and the left parietal lobe And increasing the ASEF (spectral edge frequency 50% of the alpha spectrum band) in the middle prefrontal cortex.
삭제delete 삭제delete 제1항에 따른 민들레 혼합 추출액 조성물을 포함하는 두뇌 쾌적성 증진용 건강기능식품.
A health functional food for enhancing brain comfort comprising the dandelion mixed extract composition according to claim 1.
제4항에 있어서, 상기 조성물 이외에, 추가로 비타민, 광물, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올 및 탄산음료에 사용되는 탄산화제 중에서 선택되는 하나 이상을 더 포함하는 것을 특징으로 하는 두뇌 쾌적성 증진용 건강기능식품.
The composition according to claim 4, further comprising at least one compound selected from the group consisting of vitamins, minerals, flavors, colorants, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloid thickening agents, pH adjusting agents, stabilizers, preservatives, glycerin, And a carbonating agent used in a carbonated drink. &Lt; RTI ID = 0.0 &gt; 21. &lt; / RTI &gt;
삭제delete 삭제delete
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KR101997023B1 (en) * 2018-11-30 2019-07-05 강원대학교산학협력단 Hydrangea macrophylla extract mixed composition for relaxation and reducing concentration and uses thereof
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윤미경 외 5명, ‘한방차가 시설이용 노인의 뇌기능지수에 미치는 효과’, 동서간호학연구지 제19권제2호, 128-137쪽, 2013년 11월.

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KR101997023B1 (en) * 2018-11-30 2019-07-05 강원대학교산학협력단 Hydrangea macrophylla extract mixed composition for relaxation and reducing concentration and uses thereof
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