KR101833570B1 - 외래 유전자 발현 증강 활성을 갖는 dna 요소 - Google Patents

외래 유전자 발현 증강 활성을 갖는 dna 요소 Download PDF

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KR101833570B1
KR101833570B1 KR1020137000305A KR20137000305A KR101833570B1 KR 101833570 B1 KR101833570 B1 KR 101833570B1 KR 1020137000305 A KR1020137000305 A KR 1020137000305A KR 20137000305 A KR20137000305 A KR 20137000305A KR 101833570 B1 KR101833570 B1 KR 101833570B1
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foreign gene
seq
dna
polynucleotide sequence
polynucleotide
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KR20130111514A (ko
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다이스케 니시미야
다츠야 이노우에
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다이이찌 산쿄 가부시키가이샤
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/10Plasmid DNA
    • C12N2800/106Plasmid DNA for vertebrates
    • C12N2800/107Plasmid DNA for vertebrates for mammalian
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/46Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020137000305A 2010-07-07 2011-07-06 외래 유전자 발현 증강 활성을 갖는 dna 요소 Active KR101833570B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2010-154782 2010-07-07
JP2010154782 2010-07-07
PCT/JP2011/065916 WO2012005378A2 (en) 2010-07-07 2011-07-06 Dna element having the activity of enhancing foreign gene expression

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020187005004A Division KR101920187B1 (ko) 2010-07-07 2011-07-06 외래 유전자 발현 증강 활성을 갖는 dna 요소
KR1020187005003A Division KR101856927B1 (ko) 2010-07-07 2011-07-06 외래 유전자 발현 증강 활성을 갖는 dna 요소

Publications (2)

Publication Number Publication Date
KR20130111514A KR20130111514A (ko) 2013-10-10
KR101833570B1 true KR101833570B1 (ko) 2018-03-02

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KR1020187005003A Active KR101856927B1 (ko) 2010-07-07 2011-07-06 외래 유전자 발현 증강 활성을 갖는 dna 요소
KR1020187005004A Active KR101920187B1 (ko) 2010-07-07 2011-07-06 외래 유전자 발현 증강 활성을 갖는 dna 요소
KR1020137000305A Active KR101833570B1 (ko) 2010-07-07 2011-07-06 외래 유전자 발현 증강 활성을 갖는 dna 요소

Family Applications Before (2)

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KR1020187005003A Active KR101856927B1 (ko) 2010-07-07 2011-07-06 외래 유전자 발현 증강 활성을 갖는 dna 요소
KR1020187005004A Active KR101920187B1 (ko) 2010-07-07 2011-07-06 외래 유전자 발현 증강 활성을 갖는 dna 요소

Country Status (14)

Country Link
US (3) US9371543B2 (OSRAM)
EP (3) EP2684961B1 (OSRAM)
JP (2) JP5859988B2 (OSRAM)
KR (3) KR101856927B1 (OSRAM)
CN (3) CN103080321A (OSRAM)
AU (3) AU2011274864B2 (OSRAM)
BR (1) BR112012033780A2 (OSRAM)
CA (2) CA2916937A1 (OSRAM)
ES (3) ES2565428T3 (OSRAM)
IL (1) IL243763A0 (OSRAM)
RU (1) RU2013104989A (OSRAM)
SG (4) SG10201505354PA (OSRAM)
TW (2) TW201604280A (OSRAM)
WO (1) WO2012005378A2 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012033780A2 (pt) * 2010-07-07 2016-05-31 Daiichi Sankyo Co Ltd polinucleotídeo, vetor de expressão do gene estranho, célula transformada, métodos para produzir uma proteína e para intensificar a expressão do gene estranho em uma célula transformada, e, uso de polinucleotídeo
AU2012344855C1 (en) 2011-11-28 2018-04-12 Daiichi Sankyo Company, Limited Promoter derived from human gene
WO2018066492A1 (ja) * 2016-10-03 2018-04-12 第一三共株式会社 Hspa5遺伝子のプロモーター
CN107881174B (zh) * 2017-11-22 2022-06-03 张宝会 一种翻译水平基因表达调控的方法及应用
US20230192893A1 (en) * 2020-05-11 2023-06-22 Samsung Bioepis Co., Ltd. Human genome-derived polynucleotide and method for producing polypeptide of interest using same
WO2023210607A1 (ja) 2022-04-26 2023-11-02 第一三共株式会社 Eno1遺伝子のプロモーター

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68919846T2 (de) * 1988-02-12 1995-07-06 Commw Scient Ind Res Org Poxvirus-vektoren.
US20070161003A1 (en) * 2003-09-29 2007-07-12 Morris David W Novel therapeutic targets in cancer
EP2105742A1 (en) * 2008-03-26 2009-09-30 Sanofi-Aventis Use of cathepsin C
JP5344682B2 (ja) * 2008-12-26 2013-11-20 グローブライド株式会社 釣糸ガイド、及び釣糸ガイドの製造方法
BR112012033780A2 (pt) * 2010-07-07 2016-05-31 Daiichi Sankyo Co Ltd polinucleotídeo, vetor de expressão do gene estranho, célula transformada, métodos para produzir uma proteína e para intensificar a expressão do gene estranho em uma célula transformada, e, uso de polinucleotídeo
AU2012344855C1 (en) * 2011-11-28 2018-04-12 Daiichi Sankyo Company, Limited Promoter derived from human gene

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NCBI GenBank: AC01003400.2. BAC clone RP11-643G5 (2003.03.15.)*
NCBI GenBank: AC010724.6. BAC clone RP11-152F13 (2001.05.09.)*

Also Published As

Publication number Publication date
TWI507523B (zh) 2015-11-11
RU2013104989A (ru) 2014-08-20
CN103865931B (zh) 2018-10-02
CN103865931A (zh) 2014-06-18
US11060108B2 (en) 2021-07-13
SG2014009187A (en) 2014-04-28
JP6039048B2 (ja) 2016-12-07
KR101920187B1 (ko) 2018-11-19
CN105950621B (zh) 2019-07-30
ES2564227T3 (es) 2016-03-21
US9371543B2 (en) 2016-06-21
ES2701091T3 (es) 2019-02-20
CA2916937A1 (en) 2012-01-12
WO2012005378A2 (en) 2012-01-12
WO2012005378A3 (en) 2012-04-12
US20130171694A1 (en) 2013-07-04
JP2016054741A (ja) 2016-04-21
US20190345515A1 (en) 2019-11-14
CN105950621A (zh) 2016-09-21
SG10201705118RA (en) 2017-07-28
EP3026117B1 (en) 2018-09-12
KR101856927B1 (ko) 2018-05-10
US20160333371A1 (en) 2016-11-17
AU2016203681A1 (en) 2016-06-23
SG186788A1 (en) 2013-02-28
IL243763A0 (en) 2016-04-21
JP5859988B2 (ja) 2016-02-16
EP2591113B1 (en) 2016-01-20
CN103080321A (zh) 2013-05-01
KR20180021247A (ko) 2018-02-28
KR20130111514A (ko) 2013-10-10
EP3026117A1 (en) 2016-06-01
KR20180021246A (ko) 2018-02-28
EP2684961A1 (en) 2014-01-15
EP2684961B1 (en) 2016-01-20
ES2565428T3 (es) 2016-04-04
TW201604280A (zh) 2016-02-01
AU2011274864B2 (en) 2016-10-06
AU2011274864A1 (en) 2013-02-07
JP2013531967A (ja) 2013-08-15
CA2804381C (en) 2016-03-22
US10407694B2 (en) 2019-09-10
AU2016203681B2 (en) 2018-04-19
AU2018200686A1 (en) 2018-02-22
TW201207103A (en) 2012-02-16
SG10201505354PA (en) 2015-08-28
AU2018200686B2 (en) 2020-02-13
EP2591113A2 (en) 2013-05-15
CA2804381A1 (en) 2012-01-12
BR112012033780A2 (pt) 2016-05-31

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