KR101817492B1 - Multi-chamber vessel - Google Patents

Abstract

The present invention relates to a compartmented container for use in a liquid such as a liquid, and it is possible to ensure the opening order of the first opening of the weak seal portion between the compartments and the subsequent opening of the weak seal portion of the small container, So as to reliably prevent erroneous operations. The compartmented container has the outer bag 10 and the inner bag 32. The outer bag 10 has the weak seal portion 28 as the first partition and the inner portion of the outer bag is sealed by the weak seal portion 28, And a compartment (29, 30) for containing the liquid medicament. The inner pocket 32 is sealed by the weak seal portion 38 to receive the medicine therein. The weak seal portion 38 becomes a second bulkhead separating the lower compartment 30 from the discharge control chamber 40 in whole or in part. The external pressure for opening the weak seal portion 38 of the inner bag 32 from the external pressure for opening the weak seal portion 28 for separating the compartments 29 and 30 is set to a large value. The weak seal portion 28 and then the inner bag 32 are first opened by the external pressure against the liquid medicine containing the outer bag 10.

Description

MULTI-CHAMBER VESSEL}

The present invention is constituted as a bag (bag-shaped body) made of a flexible synthetic resin film for use in an infusion solution or the like, and the inside can be partitioned by a peelable fused portion, And a method of sealing the same.

A liquid bag for a high calorie liquid for patients after surgery, comprising a liquid pharmaceutical agent containing amino acid and a liquid pharmaceutical agent containing glucose, which is a synthetic resin film as a raw material and has a risk of quality change over time by mixing, (Baffle) in a separate compartment which is partitioned by a partition (partition). The liquid bag is widened at the connection portion with the weak seal portion by pressing one of the liquid containing portion of the liquid receiving portion with the palm or the like from the outside immediately before the liquid is injected to apply the external pressure to the weak seal portion to separate the compartment Peeling and mixing of the two drugs can be performed to provide the solution. As an improvement of such a two-liquid mixed sap, it has been proposed that a compact bag-shaped body is housed in a compartment by supplying micronutrients such as vitamins for patients who continue to take liquid over a long period of time (Patent Documents 1 to 3). That is, in the technologies of Patent Documents 1 and 2, all of the compartmented containers are composed of a container body formed of a synthetic resin film and a small container (inner container) housed inside the container body. And the weak seal portion is fixed to the opposing face of the outer container body (strong seal). Therefore, the expansion / contraction of the opposing face of the container body at the time of slight seal opening between the compartments is connected by the opening of the inner container, so that the medicine contained in the inner container is mixed with the medicine contained in the compartment, Liquid) can be obtained.

In the technique of Patent Document 3, the small-sized container is disposed between the compartments and extends in the width direction. The small container is constructed by sealing the upper and the lower portions of the container (weak seal), and the opening portion is welded (Strong seal). Therefore, the opening portion of the small container is peeled and opened at the start of opening of the container by the external pressure for the compartment communication, and the medicine contained in the inner container is mixed with the medicine contained in the compartment and discharged from the discharge port.

On the other hand, in addition to the inner vessel, a weak seal portion (second partition) having a larger external pressure value for opening from the seal portion is formed in the discharge port in addition to the weak seal portion (first partition) It is proposed that the first partition wall is formed so that the mixing of the chemical solution by the opening of the first partition wall and then the opening of the second partition wall by pressurization are performed to surely cause the mixing of the inter-compartment medicine, (Patent Document 4).

Patent Document 1: Japanese Patent Publication No. 4096200 Patent Document 2: Japanese Patent Publication No. 4822860 Patent Document 3: JP-A-2004-313487 Patent Document 4: Japanese Patent Publication No. 4236131

In Patent Documents 1 to 3, it is assumed that the weak seal portion is opened by pressing the chemical liquid portion in the compartment on the side of the gap from the discharge port, and therefore the inner container is formed in the compartment on the side to be pressed, The opening and the opening of the inner container can be interlocked. Further, a description is given on the surface of the product for the necessity of performing the opening operation by pressing the predetermined portion (the compartment on the side closer to the outlet from the outlet) prior to the liquid so as to prevent the liquid from remaining untreated. However, in the prior art, since the compartment on the discharge side (lower side) is directly opened to the discharge port, it is possible to discharge the liquid from the lower compartment by puncturing the liquid set without opening. In this case, There is a possibility that the liquid may be mixed without mixing the liquid or introducing a small amount of the medicament.

In Patent Document 4, a second partition is formed in front of the discharge port in addition to the first partition between the compartments, and the external force for separation and opening of the second partition is made larger than that of the first partition, 2 barrier ribs. However, the present invention does not provide an inner container, and does not provide any solution to the above problem in a liquid bag having an inner container.

The present invention has been made in view of the above-mentioned problems in a compartment containing an inner container, and it is possible to ensure the opening sequence of the first opening of the first partition between the compartments and the subsequent opening of the second partition in front of the outlet, It is possible to securely open the inner container and to reliably exclude the possibility of an erroneous operation in which the liquid is sucked only with a part of the medicament.

The compartmented container of the present invention comprises: an outer container formed from a flexible film in a bag-like shape; a discharge port for discharging the medicine, which is fixed to the outer peripheral portion of the outer container; A first partition wall which can be opened by an external force to the outer container and a second partition which divides the inside of the outer container on the side close to the discharge port and which can be opened by an external force to an outer container larger than an external force for opening the first partition, A first compartment formed in the outer container at an interval from the discharge port of the first partition and accommodating the first liquid medicament and a second compartment formed in the outer container between the first partition and the second partition, A discharge compartment formed in the outer container between the second compartment and the discharge port and communicating with the discharge port, An inner container which is formed from a film and which is disposed inside the discharge control chamber on the side close to the discharge port of the second compartment and contains an auxiliary medicament and has a seal portion which is configured to be releasable along the outer periphery; And an external force applying portion for attaching the sealing portion to the inner surface of the outer container and for applying an external force for opening the sealing portion of the inner container.

The flexible film constituting the inner container may be thermoformed into a recess for forming a hollow portion for receiving the medicine.

The second partition wall has a sealing portion of the inner container on the side close to the second compartment and a connecting portion connecting the both side ends of the sealing portion of the inner container close to the second compartment to the side of the outer container for separating the second compartment and the discharge control chamber Can be configured.

At the second compartment side end portion of the inner container along the external force applying portion, the fixed portion of the inner container to the opposite inner surface of the outer container at the external force applying portion can be extended to some extent from the sealing portion to the second compartment of the inner container . Further, it is possible to prevent the fixing portion from substantially overlapping with the sealing portion of the inner container.

It is possible to form an auxiliary external force applying portion for locally securing the separated side of the sealed portion of the inner container with the second compartment to the opposing face of the outer container. Auxiliary external force application (local seal part) can be installed in pairs so as to fit the discharge port.

Further, the present invention is a method for sealing a compartmented container as described above, which comprises preparing an outer container with an outer sealant sealant at a gap side from the compartment and sealing the outer periphery with an encapsulating portion Wherein the inner container is inserted into the outer container from the unsealed portion and the sealed portion of the inner container is welded to the inner surface of the outer container on the side close to the compartment to form an external force applying portion. To provide a sealing method. The flexible film constituting the inner container is provided with an inner layer having a deposition temperature higher than the deposition temperature for forming the external force application portion and the flexible film constituting the inner container is provided with a sealing film It is possible to seal the external force applying portion by using the seal mold having the extending portion extending to the actual side and having the heating surface of the size covering the extended portion for forming the external force applying portion.

In manufacturing the inner container in the compartmented container, the middle portion in the widthwise direction of the flattened bag-shaped film sheet is peelably center-sealed, and both ends of the closed container are cut off to insert the infusion nozzle so as to follow the center seal through the sheet opening portion And a bottom seal is formed by a seal mold and a bottom seal so that the seal can be peeled off from the sheet by a seal mold. After a sheet is fed, a predetermined amount of medicament is injected into the cavity from the injection nozzle, To close the top of the cavity after drug injection. As described above, all the steps of formation of the closed space of the cavity closed at the bottom by the side seal and the cross seal, injection of the medicine, and top closure by the cross seal are repeated while cooperating properly with the transport of the sheet, . The protective film is peelably adhered to the sheet surface serving as the outermost surface when the inner container is used in the next step, and the protective film is peeled off at the time of attachment to the outer container.

The cavity for injecting the chemical liquid can be formed into a shape-fixed cavity by press-molding the film with the seal mold from the outer diameter portion of the injection nozzle at the time of sealing.

The inner container is disposed inside the outer container between the second compartment and the discharge control chamber and the outer container is fixed to the inner surface of the outer container along the side close to the second compartment, It is possible to open the sealed portion of the inner container in cooperation with the opening of the second partition wall following the opening of the first partition wall by opening the second partition wall as compared with the first partition wall, It can be mixed with the medicament contained in the inner container and introduced into the discharge port.

Further, by making the vicinity of the second compartment in the sealing portion of the inner container participate in the formation of the second partition wall, the opening function of the inner container due to the external force is not impaired and the limited internal space of the outer container can be effectively used On the other hand, the outer surface of the inner container can remain substantially open to the discharge control chamber on the front surface (other than the welded portion), and by the steam of a small amount of the injection water accommodated in the discharge control chamber at the time of sterilization, The inside can be sterilized.

It is possible to effectively prevent the external force from expanding between the films constituting the outer container at the time of opening to the sealing portion of the inner container efficiently And can lead to efficient opening.

The external force exerted on the second partition wall can be contributed to the efficient opening of the inner container by locally securing the sealed portion of the inner container on the opposite side from the second compartment to the opposite inner surface of the outer container. On the other hand, the inner container is exposed to the discharge control chamber on the substantial front surface at the outer surface, and the sterilization function of the inner container is not impaired. The auxiliary external force applying portion prevents the posture collapse of the inner container which can occur when the inner container is pulled by the second compartment side by the container shape and precisely maintains the posture of the inner container at the time of opening, The opening operation can be realized.

It is possible to efficiently manufacture the inner container by cutting the inner container one by one from the chain member of the drug packed portion to be sealed and filled in the bag-shaped film sheet, and by thermally molding the cavity portion for receiving the medicine at the time of sealing, The convex surface shape of the sheet is fixed and it is hard to crumble, so that a small-sized portion for a small amount of medicine can be surely secured. In addition, it is possible to prevent the adhesion of the foreign matter and ensure the sterility of the foreign matter during the time until the protective film is attached to the outer container.

1 is a plan view of a compartmentalized container according to a first embodiment of the present invention.
2 is a cross-sectional view taken along the line II-II in Fig.
3 is a cross-sectional view taken along the line III-III in Fig.
4 is a cross-sectional view taken along the line IV-IV in Fig.
Fig. 5 is a view schematically showing steps (a) to (c) in the manufacturing process of the compartmentalized container of Fig. 1;
Figure 6 is a diagram schematically illustrating steps (d) to (f) subsequent to Figure 5
Fig. 7 is a cross-sectional view taken along the line VII-VII in Fig. 5 (C), showing the step (a) of bonding the inner bag to the resin material constituting the outer bag by the seal mold at the time of forming the steel seal portion, , and (b), respectively.
8 is a plan view of a compartmentalized container according to a second embodiment of the present invention.
9 is a cross-sectional view taken along the line IX-IX in Fig.
10 is a plan view of a compartmentalized container according to a third embodiment of the present invention.
11 is a plan view of a compartmentalized container according to a fourth embodiment of the present invention.
Fig. 12 is a cross-sectional view of an arrow along line XII-XII in Fig. 11. Fig.
13 is a cross-sectional view taken along the line XIII-XIII in Fig. 11; Fig.
14 is a plan view of a compartmentalized container according to a fifth embodiment of the present invention.
15 is a plan view of a compartmentalized container according to a sixth embodiment of the present invention.
16 is a cross-sectional view taken along the line XVI-XVI in Fig.
Fig. 17 is a partial view of Fig. 16, but schematically shows the positional relationship between the seal mold, the outer bag and the inner bag at the time of forming a strong seal as an external force application.
18 is a plan view of a compartmentalized container in a seventh embodiment of the present invention.
Fig. 19 is a plan view of a compartmentalized container in an eighth embodiment of the present invention. Fig.
Fig. 20 is a schematic side view of an apparatus for manufacturing an inner bag in the compartment of Fig. 19;
21 is a schematic front view of an apparatus for manufacturing an inner bag in the compartment of Fig. 19;
22 is a schematic cross-sectional view of a film constituting the inner bag in the compartmented container of Fig. 19;
FIG. 23 is a cross-sectional view of an arrow along the line XXIII-XXIII in FIG. 20; FIG.
Fig. 24 is a cross-sectional view taken along the line XXIV-XXIV in Fig. 20; Fig.
Fig. 25 is a cross-sectional view taken along the line XXV-XXV in Fig. 21; Fig.
Fig. 26 is a cross-sectional view taken along the line XXVI-XXVI in Fig. 20, wherein (a) shows the state before the seal metal mold is combined, and (b) shows the state after the metal mold.
FIG. 27 is a cross-sectional view taken along the line XXVII-XXVII in FIG.

A first embodiment of a compartmented container of the present invention which is implemented as a liquid bag will be described. In Fig. 1, reference numeral 10 denotes an outer bag (outer container of the present invention) formed by inflation or the like, A flexible synthetic resin film (flexible film of the present invention) having a multilayer structure such as a film is used as a material. 2 and 3, the synthetic resin soft film constituting the outer bag 10 has a pair of (upper and lower) film pieces 12 and 14 And is formed in a bag-like shape by releasably welding or peeling the entire circumference of the outer rim along the opposite face. This steel seal portion along the outer bag 10 is indicated by reference numeral 16 in Fig. It is possible to prevent the sealing surface from being peeled off even when the chemical-solution receiving portion of the outer bag 10 is pressurized from the outside at the time of melting the steel seal portion 16, The welding temperature and the welding time are set so that the fixed state is maintained. A discharge port 18 is fixed to the lower portion of the outer bag 10 and a mixing port 20 is fixed to the upper portion of the outer bag 10 so as to maintain an oil-tight state in the steel seal portion 16 have. The discharge port 18 and the mixing port 20 of the outer bag 10 are formed into a metal mold with the same material as the synthetic resin flexible film constituting the outer bag 10 in order to improve the weldability thereof. That is, when the outer bag 10 is made of polyethylene, the outlet 18 and the inner bag 20 are made of polyethylene. The discharge port 18 and the mixing port 20 are integrated with the outer bag 10 by releasably welding them to the upper and lower film pieces 12 and 14. The film pieces 12 and 14 constituting the outer bag 10 are separated from each other by the discharge port 18 and the mixing port 20 in order to integrate the outer bag 10 with the discharge port 18 and the mixing port 20, Tightly adhered to the outer periphery of the outer bag 10 so as to be liquid tight at the periphery thereof and to be seamlessly connected to the outer periphery of the outer bag 10 without any seam. The welded portions of the discharge port 18 and the ferrule 20 in the steel seal portion 16 are denoted by reference numerals 16A and 16B (Fig. 1). The discharge port 18 and the mixing port 20 are thick molded products of a synthetic resin capable of retaining the shape of the cylinder and the structure thereof is basically the same. However, with respect to the discharge port 18, The tubular body 22 is provided with a tubular body 22 and a cap 24 and a rubber stopper 26. The tubular body 22 has a tip end 22-1 which is in contact with the outer pocket And the tubular body 22 protrudes outside the outer bag 10 via the tapered portion 22-2 and the cap 24 is attached to the end of the tubular body 22 with a rubber stopper (Welded) by sandwiched between the first and second plates 26. The rubber stopper 26 is for puncturing the needle of the liquid set. The mixing port 20 (Fig. 1) has the same configuration as the discharge port 18 and provides a rubber stopper, such as the rubber stopper 26 of the discharge port 18, though not shown, It is possible to do.

In this embodiment, both of the steel seal portion (non-removable welded portion) and the weak seal portion (peelable welded portion) are formed by welding the film opposing surfaces. However, 9, 12, 13, 16, and 17), for the sake of clarity, the welded portions in the steel seal portion and the weak seal portion are shown by thick lines (steel seal is solid line and weak seal is broken line).

An opening 27 (FIG. 1) is formed in the upper portion of the outer periphery of the outer bag 10 in the steel seal portion 16 for suspension in the receiver.

1, reference numeral 28 denotes a weak seal portion (a first partition of the present invention) formed by welding the upper and lower film pieces 12 and 14 constituting the outer bag 10 in such a manner that the upper and lower film pieces 12 and 14 are peelably welded 2 and Fig. 3). The weak seal portion 28 is formed so that the intermediate portion in the height direction of the outer bag 10 extends over the entire width, that is, the strong seal portion 16 on both sides of the outer bag 10, The inner space of the outer bag 10 is separated into the upper and lower first and second compartments 29 and 30. Although the liquid medicines are individually contained (separated) in the first and second compartments 29 and 30, the liquid medicament is a chemical solution containing a liquid medicine and glucose containing amino acids in the case of high calorie liquid. When the weak seal portion 28 is melted by the widening of the outer bag 10 at the connection portion with the weak seal portion 28 when the liquid containing portion of the compartments 29 and 30 is pressed from the outside The welding temperature and the welding time are appropriately set so that the peeling of the sealing surface occurs. The melting point of the polyethylene> the sealing temperature of the strong sealing portion 16> the sealing temperature of the sealing portion 28 because the opposing surfaces of the strong sealing portion 16 and the weak sealing portion 28 are the same as those of the polyethylene film . Specifically, the seal temperature of the steel seal portion 16 of the polyethylene films (also the steel seal portion 42 described later) is about 150 占 폚, and the seal temperature of the seal portion 28 is about 130 占 폚.

The inner pocket 32 (inner container of the present invention) is intended to contain an auxiliary medicament such as vitamins in the case of a high calorie liquid. The inner pocket 32 has a flat, elongated rectangular shape and is accommodated between the lower compartment 30 and the outlet 18 in the inside of the outer bag 10. The inner bag 32 is connected to and fixed to the outer bag 10 by an external force imparting portion 42 described later (a strong seal portion 42), is subjected to fluid pressure inside the outer bag 10, Loses. An outer edge of the inner bag 32 which is fixed to the inner side of the steel seal portion and overlapped with the steel seal portions 16 and 42 is shown by a broken line 32 'in FIG. The inner pouch 32 is made of a multilayer polyethylene film such as the outer pouch 10 as a material, but it can be provided with a special surface layer that is in direct contact with the medicament for chemical resistance, For example, when the trace amount or trace amount of the drug is vitamin, a surface layer of a cyclic polyolefin resin (COP) (the inner surface of the inner pouch 32) can be formed on the base layer made of the multilayer polyethylene film. The polyethylene layer and the COP resin layer constituting the substrate layer can be molded into a bag-like shape in a state of being firmly integrated under heating by inflation molding due to the strong affinity between the resins. For the construction of the multilayer film constituting the inner bag 32, see the description of Fig. 23 relating to another embodiment shown in Fig. As shown in Fig. 2, the inner bag 32 consists of upper and lower film pieces 34 and 36. In this embodiment, only one liquid is accommodated for clarity and the upper and lower film pieces 34, And the bonded portion is formed as a weak seal portion 38 (sealing portion of the present invention) to form a medicine containing chamber 39 therein, and a trace amount of medicines such as vitamins are contained therein. Since the inner pocket 32 is formed in a rectangular shape, the weak seal portion 38 is formed in the left and right side portions 38-1 and 38-2 and the upper and lower side portions 38-3 and 38-4 . The value of the external force for separating and opening the weak seal portion 38 is set so that the welding temperature and the welding time are set so as to become larger than the value of the external force for separating and opening the weak seal portion 28 between the compartments 29, do. By the later-described fixing structure of the inner bag 32 with respect to the outer bag 10, mixing of the chemical liquid between the compartments 29, 30 due to the opening of the weak seal portion 28 by external force, It is possible to secure a sequence of opening sequence of introducing a trace amount of medicament into the mixed medicament solution by opening of the valve 38. Since the weld surface of the weak seal portion 28 is a polyethylene film and the weld surface of the weak seal portion 38 is an annular polyolefin based resin film, the welding conditions are set separately for the same peelable seal, It is necessary to set the external force for opening the " weak seal portion 38 " The weak seal 28 separating the compartments 29 and 30 from each other is a polyethylene film having a temperature of about 130 ° C. as described above while the weak seal portion 38 of the inner pocket 32 is sealed, The sealing temperature of the annular polyolefin based resin films is high and the melting temperature of the material is high. Therefore, if the external force for opening the weak seal portion 28 is required to be an external force for opening the weak seal portion 38, Even if the seal is about 180 ° C.

The discharge control chamber 40 is formed inside the outer vessel 10 between the lower compartment 30 and the discharge port 18 and is always open to the discharge port 18. The inner pocket 32 is disposed inside the discharge control chamber 40 between the second compartment 30 and the discharge port 18 although this is a general positional relationship with the inner pocket 32. [

Next, a description will be given in detail of a fixing structure of the inner bag 32 with respect to the outer bag 10 in the embodiment of the present invention. In this embodiment, the inner bag 32 is formed so as to be close to all the widths of the outer bag 10, The width of the inner bag 32 is narrower than the width of the outer bag 10 to some extent. 5 and 6, the upper and lower ends 38-3 and 38-1 of the weak seal portion 38 (sealing portion) of the inner bag 32, 38-2 are sandwiched by the film pieces 12, 14 constituting the outer bag portion at the outer edge portion, and the width of the steel seal portion 16 at this portion is taken to be somewhat wide so as to form a widened portion 16-1). (If the inner pocket 32 can be held, it may be the same width without being wide.) The widthwise ends of the upper side portion 38-3 of the weak seal portion 38 of the inner bag 32 are sandwiched between the upper and lower film pieces 12 and 14 of the thickened portion 16-1 of the steel seal portion 16 The bottom edge of the lower compartment 30 is partitioned and the lower compartment 30 and the discharge control chamber 40 are liquid-tightly separated. That is, the upper side portion 38-3 of the weak seal portion 38 of the inner bag 32 (the weak seal portion 38 on the side close to the second compartment 30 of the inner container) The weakened portion 16-1 of the inner container (the weak seal portion 38 on the side close to the second compartment 30 of the inner container is connected to the outer compartment side 16 of the outer container at both ends thereof) 40) constituting the connecting portion of the present invention, which constitute the second partition of the present invention in this embodiment. That is, the lower compartment 30 has the weak seal portion 28 as the first partition and the upper portion 38-3 of the weak seal portion 38 of the inner pocket 32 are connected to the wide portion 16 -1) of the first barrier ribs. The upper side portion 38-3 of the weak seal portion 38 of the inner bag 32 is inserted into the discharge hole 18 of the strong seal 16 And the second partition formed by integrating the light with the wide-width portion 16-1 divides the upper side of the discharge control chamber 40. [ The discharge control chamber 40 serves to guide the chemical liquid in the compartments 29 and 30 to the discharge port 18 together with a small amount of medicament in the inner pocket 32 when the weak seal portion 38 is opened. The structure of this embodiment in which the upper side portion 38-3 of the weak seal portion 38 of the inner bag 32 is also used as the second partition wall which is the lower edge of the lower compartment 30, The outer surface of the inner pocket 32 can be effectively used in the discharge control chamber 40 (40) except for the welded portions 38-3, 38-1, 38-2, 44 with the steel seals 16, , It is advantageous for sterilizing the inner bag 32 as described later. In this embodiment, the left and right side portions 38-1 and 38-2 of the weak seal portion 38 of the inner bag 32 are also sandwiched between the film pieces 12 and 14 constituting the deepening portion 16-1 And is tightly sealed. That is, the strong seal portion 16 (the thickened portion 16-1), which is welded to both ends of the upper portion 38-3 of the inner bag 32 and constitutes the connecting portion of the present invention, And also to both the right and left side portions 38-1 and 38-2. This structure holds the left and right side portions 38-1 and 38-2 of the inner bag 32 at the time of opening so that an external force is concentrated on the upper side portion 38-3 and the lower side portion 38-4 of the inner bag 32 So that it is possible to contribute to the smooth discharge of the chemical solution.

Next, the fixing structure of the inner bag 32 with respect to the outer bag 10 for opening the inner bag 32 by an external force against the outer bag 10 will be described in detail. The inner bag 32 has an outer periphery The right and left side portions 38-1 and 38-2 (Fig. 1) in the width direction of the weak seal portion 38 along the width direction of the tight seal portion 16 (the thickening portion 16-1) And the upper side 38-3 (Figs. 1, 3, and 4) are welded to the upper and lower film pieces 12 and 14 of the outer bag 10 along all widths 12 and 14) are opposed to each other by steel seals (non-removable welded = fixed). The upper sealed portion 38-3 of the inner bag 32 is denoted by the reference numeral 42 with respect to the opposing face of the outer bag 10 and the strong sealed portion 42 (See Figs. 2 and 3) along the entire width so as to be integrally joined to both the right and left side portions of the inner pocket 32 and the upper side portion 38-3 of the weak seal portion 38 of the inner pocket 32, And is extended. The inner seal pocket 32 is secured to the inside of the outer bag 10 by the steel seal part 42 on the side close to the second compartment and by the action of pressure externally, the inner bag 32 is widened and opened . The inner pouch 32 is attached to the lower side portion 38-4 (on the side close to the discharge port 18) of the weak seal portion 38 along the outer periphery, except for the point seal portion 44 to be described later, And is free from the bag 10. Therefore, the non-expendable portion on the outer surface of the inner bag 32 can be opened in the discharge control chamber 40. [ The discharge control chamber 40 can be filled with a small amount of water for sterilization under the humid atmosphere in the manufacturing process of the liquid bag. The inner pouch 32 is disposed in the widthwise direction at the lower side portion 38-4 of the weak seal portion 38 along the outer periphery (the side away from the second compartment 30 of the sealing portion in the inner pocket 32) (So-called point seal) locally on the opposite face of the outer bag 10 at the central portion, and the local steel seal portion (whether or not the auxiliary external force applying portion of the present invention) is indicated by reference numeral 44 ). The local steel seal portion 44 can contribute to the opening of the entire periphery of the inner bag 32 by the external force and the posture at the time of opening. Since the steel seal part 42 as the external force applying part of the present invention is the fusion of the polyethylene on the outer surface of the inner pocket 32 with respect to the inner surface of the outer bag 10 and the welding temperature is about 150 DEG C as described above, The inner surfaces of the inner pouch 32 which are the annular polyolefins are not welded even if they are stuck between the seal molds and the inner surface of the inner surface of the inner surface of the inner surface of the inner surface of the inner surface The weak seal portion 38 remains the weak seal portion.

The external force application portion of the present invention for transferring an external force to the outer bag 10 at the time of opening of the bag into the inner pocket 32 for opening the bag is constituted by the strong seal portion 42 and the strong seal portion 42 is constituted by the inner pocket 32 in the widthwise direction so as to overlap with the upper portion 38-3 of the weak seal portion 38 of the upper portion 38-3. 2 and 3, the steel seal portion 42 (the welded portion between the opposed surfaces is shown by a thick solid line) and the upper side portion 38-3 of the weak seal portion 38 are substantially perpendicular to the ground It extends to all widths. The upper portion 38-3 of the weak seal portion 38 of the inner pouch 32 (indicated by the thick broken line between the opposite surfaces) has the upper and lower synthetic resin film pieces 34-1 and 36-1 of the upper and lower synthetic resin film pieces 34 and 36 are directed toward the inside of the compartment 30 along the inner surfaces of the upper and lower synthetic resin film pieces 12 and 14 forming the outer bag 10 And these edge portions 34-1 and 36-1 are welded to the opposing faces of the upper and lower film pieces 12 and 14 constituting the outer bag 10 by means of steel welding 34-1 and 36-1 of the film pieces 34 and 36 constituting the inner bag 32 are denoted by the reference numeral 42 ' 36-l), the inner surfaces are of course separated. In other words, compared with the bonded portion (the upper portion 38-3 of the weak seal portion 38) indicated by the thick dotted line of the inner surfaces between the film pieces 34 and 36 constituting the inner bag 32, (Welded portion 42) shown by a thick solid line on the inner surfaces of the upper and lower film pieces 12 and 14 and the outer surfaces of the film pieces 34 and 36 constituting the inner pocket 32 constitute the compartment (Not shown). The upper and lower film pieces 12 and 14 constituting the outer bag 10 are separated from the compartment 30 in the film pieces 34 and 36 constituting the inner bag 32 by the strong seal portions 42 and 42 ' This configuration, which is welded to the extensions 34-1 and 36-1 of the outer bag 10 at the time of unsealing, is characterized in that an external force due to the expansion between the film pieces 12 and 14 constituting the outer bag 10 at the time of unsealing, It is possible to efficiently transfer the weak seal portion 38 of the inner bag 32, particularly, to the upper side portion 38-3 serving as the opening origin of the inner bag 32 via the edge portions 34-1 and 36-1 , And may help to ensure the opening of the inner bag 32. [

In the present invention, the resin layer constituting the inner surface of the inner bag 32 is formed of a cyclic polyolefin resin film or the like and has a structure in which a material (polyethylene) like the outer bag 10 is formed into a multilayer (Such as a cyclic polyolefin resin) constituting the inner surface of the inner bag 32 has a melting temperature which is considerably higher than the melting temperature of the resin (such as polyethylene) constituting the upper layer, and therefore, The finished inner bag 32 is received in the outer bag 10 and is tightly sealed from the outside with a sealing metal so that the inner bag 32 is interposed between the inner surface of the outer bag 10 and the outer surface of the inner bag 32 (Annular polyolefin-based resin films in the embodiment) do not reach to be welded even when the steel seals 42, 42 ', and 44 are made (the seal temperature is about 150 ° C) , From about anjumeoni seal 32 by the temperature of the metal part 38 there is if they are about the sealing state is damaged suitable (sealing temperature is about 180 ℃).

Figs. 5 and 6 (a) to 6 (f) illustrate one example of the manufacturing process of the liquid bag of the first embodiment in order. The tubular synthetic resin film is wound on a roll, The material 48 to be an outer bag is subjected to a process of forming a tubular polyethylene multilayered film sheet drawn out from the roll, including a steel seal in a product and a part of a part to be a weak seal, (The upper and lower surfaces of the tubular sheet are fused), and then trimmed according to the contour of the outer bag 10. The outer circumferential portion of the material 48 is tightly sealed in this place and becomes a part of the steel seal portion 16 (Fig. 1) of the product. Further, the weak seal portion 28 is already formed. A portion of the micro-part which will be the attachment part of the mouthpiece later is denoted by reference numeral 48-1.

The next step (b) shows the inserting process of the previously prepared inner bag 32. As described above with reference to Figs. 1 to 4, the inner pocket 32 has the outer periphery thereof as the weak seal portion 38, and the outer surface of the inner pocket 32 is covered with a separable protective film Lt; / RTI > The width W1 of the inner bag 32 is taken to be somewhat narrower than the width W2 of the material 48 to be the outer bag and the end 48-2 of the material 48 to be the outlet- The inner bag 32 is peeled off between the upper and lower film pieces at the end portion 48-2, and then the upper and lower films are separately cut and inserted to a predetermined position (indicated by arrow A). Specific examples of the inner bag manufacturing process will be described later in connection with the embodiment of Fig.

The step (c) shows a fixing (strong sealing) process to the inner bag material 48 after the insertion, and a pair of opposing heating surfaces are stuck to each other in the widthwise direction, The inner side (compartment side) side portion 38-3 of the portion 38 is strongly welded to the inner surface of the opposite side of the outer bag material 48 and the strong seal portion 42 And a light-shielding portion 16-1 for fixing the side portions 38-1 and 38-2 of the inner bag 32 in the steel seal portion 16 is also formed. The seal mold for forming the steel seal part 42 has a heating surface of a size corresponding to the size of the steel seal part. However, the inner surface of the film pieces 12, 14 constituting the outer bag 10 and the inner pocket 32 The outer surfaces of the constituting films 34 and 36 are polyethylene films and are formed by the seal mold at a temperature of about 150 DEG C as described above to the side of the compartment 30 of the inner bag 32 shown in Figs. And is strongly sealed until reaching the extending end portions 34-1 and 36-1, so that a strong seal portion 42 (a portion indicated by the reference numeral 42 ') is formed. The seal mold naturally pressurizes the inner surfaces of the extending ends 34-1 and 36-1 of the film pieces 34 and 36 constituting the inner bag 32 toward the side of the compartment 30, The annular polyolefin resin constituting the inner surface has a high melting temperature and therefore the end portions of the film pieces 34 and 36 constituting the inner pocket 32 in the seal mold heated to about 150 ° C toward the side of the compartment 30 34-1, 36-1) are not welded on the inner surfaces. Further, the heat of the seal mold is applied to the weak seal portion 38 of the inner bag 32, while the weak seal portion 38 remains the weak seal.

7A and 7B are sectional views schematically showing the formation of a steel seal portion 42 by a seal mold and the mold is divided into an upper die 102 and a lower die 104 The outer bag material 48 and the inner bag 32 are stuck between the upper and lower dies 102 and 104 heated to a predetermined temperature of about 150 DEG C and the outer bag material 48 is stuck, And the inner bag 32 are brought into close contact with each other as shown in Fig. 7 (a) under the heating by the upper and lower dies 102 and 104 on the opposite surface. At this time, as well as the sealing portion 38-3 of the film pieces 34 and 36 constituting the inner bag 32, the extending end portions 34-1 and 36-1 from the sealing portion 38-3 are also heated, Lt; / RTI > Therefore, not only the outer surface of the sealing portion 38-3, but also the outer surfaces of the extending end portions 34-1 and 36-1 are tightly sealed at the low melting temperature, particularly the opposite inner surfaces of the outer bag material 48. [ And, since the inner surfaces of the extending ends 34-1 and 36-1 are the high melting temperature layers, welding does not occur regardless of the pressing under heating by the dies 102 and 104. [ The sealing portion 38-3 is maintained as a weak seal regardless of the heat in the seal mold due to the high melting temperature (about 180 DEG C as described above) of the resin film layer constituting the inner surface. After the predetermined welding time has elapsed, the upper and lower dies 102 and 104 are separated as shown in Fig. 7 (b). The inner surface of the outer bag material 48 and the outer surface of the inner bag 32 are welded together (thick solid line) to form a steel seal portion 42. The outer surfaces of the extending ends 34-1, The sealing portion 38 (the lower side portion 38-4) is kept in a sealed state (thick broken line) on the opposite inner surface of the outer bag 10 in Fig. 3, The attachment structure of the inner bag 32 is obtained. It should be noted that the positional relationship is reversed in FIGS. 3 and 7 in the construction.

In the step (d) shown in Fig. 6, the end portion 48-4 on the discharge port side of the material 48, which is a part of the steel seal portion 16 on the outer periphery of the outer bag, A point seal portion 44 (Fig. 2) for fixing to the opposite face of the outer bag is also formed, but a portion indicated by reference numeral 48-5 is left as a mounting opening of the discharge port 18 to remain unfixed.

In the step (e), the discharge port 18 to the microreaction site 48-5 is mounted and sealed, and this is the same as already described in Figs. 1 and 2, (See also Fig. 5 (a)), the mixing port 20 is inserted and is tightly sealed in the same manner as the discharge port 18, and the steel seal portions 16A and 16B ) Is formed. Thereby, the discharge control chamber 40 is sealed. Prior to the formation of the seal in the discharge control chamber 40, a small amount of distilled water is filled in for sterilization under the humid heat to be described later. In this state, the regions 48-6 and 48-7 of the material 48 remain unchanged.

In the next step, the respective chemical liquids are filled at the micro portions 48-6 and 48-7 of the material 48 (arrows B and C). The chemical liquid filling can be performed at the same time. After the chemical liquid is filled, strong sealing of the microreactive portions 48-6 and 48-7 is performed, and compartments 29 and 30 filled with the respective chemical liquids are obtained. (f) shows a completed bag (as shown in Fig. 1).

The finished bag is then sterilized by a steam sterilizer. The side portions 38-1 and 38-2 and the side portion 38-3 on the second compartment side are fixed to the face of the outer bag by the strong seal portions 16 and 42. However, Since the side portion 38-4 on the discharge port side is only fixed to the opposite face of the outer bag by the point seal portion 44 and the inner bag 32 is exposed to the discharge control chamber 40 on all the outer surfaces except for the strongly bonded portion , The outer surface of the inner pocket 32 can be sterilized under humid heat. That is, the water filled in the discharge control chamber 40 in the step (e) is evaporated by the heating in the steam sterilizer to become steam and filled in the discharge control chamber 40, so that the outer surface of the inner pocket 32 can be efficiently Lt; / RTI >

In the liquid bag according to the embodiment described above, the liquid bag is placed on a table such as a desk, and one or both of the liquid holding portions of the compartments 29 and 30 are pressed from the outside to the palm I do. The outer bag 10 is widened at the connection with the weak seal 28 at the side of the compartment 29 and the compartments 29 and 30 are opened at the side of the compartment 29. [ The weak seal 28 is first opened by an external force applied to the weak seal 28 that separates the weak seal 28. [ When the compartments 30 on both sides of the compartments 29 and 30 are pressed only by the compartments 30 on the side of the compartments 29 and 30, the outer bag 10 is connected to the connection portion of the weak seal 28 on the compartment 30 side, (The upper side portion 38-3). The force transmission to the connection portion of the weak seal 38 to the upper side portion 38-3 is such that the synthetic resin film piece constituting the outer bag 10 is stuck to the upper side portion 38C of the weak seal 38 38-3, respectively. However, as described above, since the external force for separating and opening the weak seal portion 38> the external force for separating and opening the weak seal portion 28, the weak seal for separating between the compartments 29 and 30 28 are peeled off, and the weak seal 38 is peeled and opened by further pressing. That is, the weak seal 38 is peeled and opened from the upper side 38-3, which is the connection portion to the outer bag 10, but the synthetic resin film piece 38 constituting the outer bag 10 12, and 14, the separation and opening of the portion 38-4 on the side of the discharge control chamber 40 is achieved. Therefore, the chemical solution contained in the upper compartment 29, the chemical solution contained in the lower compartment 30, and the medicine contained in the inner pocket 32 can all be led to the discharge port 18, .

2 and 3, a steel seal portion (an external force applying portion of the present invention) 42 is formed along the upper side portion 38-3 of the weak seal 38 (see Fig. 2 And the plane orthogonal direction of Fig. 3). The ends 34-1 and 36-1 of the upper and lower synthetic resin films 34 and 36 constituting the inner bag 32 extend toward the compartment 30 and extend toward the compartment 30 The upper and lower films 12 and 14 constituting the outer bag 10 are tightly sealed to the inner surfaces of the upper and lower films 12 and 14 constituting the outer bag 10 at the time of opening of the infusion bag, The external force caused by the expansion of the upper and lower films 12 and 14 is transmitted to the inner pocket 32 through the upper and lower film end portions 34-1 and 36-1 constituting the inner pocket 32 expanding following the upper and lower films 12 and 14. [ Which is a bonded portion of the inner and outer surfaces of the upper and lower films 34 and 36 constituting the upper and lower films 34 and 36, 38 can be reliably opened. 1, the weak seal portion 38 of the inner bag 32 is attached to the strong seal portion 16 (the thickening portion 16-1 in Fig. 1) in both the right and left side portions 38-1 and 38-2. When the external force is applied to the weak seal portion 38, the strong seal portion 16 receives the force that the inner bag 32 is attracted to the inner surface facing portion of the outer bag 10, The upper and lower portions 38-3 and 38-4 of the weak seal portion 38 which is the flow direction of the liquid solution are surely opened and the liquid is supplied to the discharge port 18 to every corner, Lt; / RTI > Since the inner bag 32 is tightly sealed to the outer bag facing surface by the point seal portion 44 at the side portion 38-4 on the side of the discharge control chamber 42, The inner bag 32 is prevented from being pulled to the side of the outlet port during the opening of the outlet port 18 so that the posture of the inner bag 32 can be appropriately maintained Can also help.

8 and 9 show a second embodiment of the present invention. The difference from the first embodiment is that a weak seal portion 60 (see FIG. 8) for peeling the upper and lower film pieces 34 and 36 of the inner pocket 32 The inside of the inner pocket 32 is partitioned into left and right compartments 62 and 64 by the weak seal portion 60 and separated into the compartments 62 and 64 separately Can be accommodated. Therefore, when the weak seal portion 38 on the outer periphery of the inner bag 32 is opened by the external force application (strong seal portion 42) under pressure from the outside of the chemical liquid in the outer bag 10, So that the medicine in the compartments 62 and 64 can be discharged toward the discharge port 18.

Fig. 10 shows another embodiment, in which the lower end 10-1 (the second compartment side) of the outer bag 10 has a shape gradually narrowed toward the outlet 18. The inner bag 32 is positioned on the lower end 10-1 of the outer bag 10. [ The weak seal portion 32 has the weak seal portion 38 (sealing portion of the present invention) along the outer periphery and the weak seal portion 38 has the left and right side portions 38-1 and 38-2 and the upper and lower side portions 38-3, 38-4). The left and right side portions 38-1 and 38-2 are inclined in accordance with the shape of the lower end 10-1 of the outer bag 10 but the upper and lower films 38-1 and 38-2 constituting the thickened portion 16-1 in the strong seal portion 16, Respectively. (Upper side portion 38-3) of the weak seal portion 38 of the inner bag 32 and the compartment 30 of the weak seal portion 32 and the portion 16-1 of the strong seal 16 form the lower compartment 30 The second partition wall for isolating the discharge control chamber 40 is formed. The upper and lower film pieces of the outer bag 10 are steel-welded to be superimposed on the upper side portion 38-3 of the weak seal portion 38 of the inner bag 32 to constitute a steel seal portion 42 to be an external force applying portion It is the same. In this embodiment, the inside of the inner bag 32 is partitioned into upper and lower compartments 72 and 74 by a weak seal portion 60 as an inner container dividing portion.

Fig. 11 shows another embodiment of the present invention. The inner bag 32 has a structure in which both ends of the upper portion 38-3 of the outer periphery weak seal portion 38 (sealing portion of the present invention) And is terminated at a significantly spaced distance from the left and right side portions of the steel seal portion 16 of the first embodiment. The lower ends of the side portions 38-1 and 38-2 of the weak seal portion 38 on the outer periphery of the inner bag 32 are also spaced apart from the lower side of the steel seal portion 16 on the outer periphery of the outer bag 10, . The inner pocket 32 is tightly sealed to the opposing face of the outer bag 10 along the upper portion 38-3 and the both side portions 38-1 and 38-2 of the weak seal portion 38, It is the same as in the first embodiment that the inner sleeve 42 constitutes the external force applying portion of the present invention and the weak seal portion 38 is peeled off by the external force to the outer bag 10 so that the inner bag 32 is opened. The steel seal portion 42 extends beyond the lower ends of the upper portion 38-3 and the both side portions 38-1 and 38-2 of the weak seal portion 38 and is connected to the upper end portion 38-3 of the weak seal portion 38, And extension portions 42-1 and 42-2 extending to the lower side of the main body 16 (see Fig. 13). The extension portions 42-1 and 42-2 fuse the synthetic resin film opposing portions constituting the outer bag. That is, in this embodiment, the upper portion 38-3 and the both-side portions 38-1 and 38-2 of the weak seal portion 38 are located close to the lower compartment 30 in the weak seal portion 38 The lower compartment 30 and the discharge control chamber 40 are oil tightly separated by forming the extension portions 42-1 and 42-2 in the steel seal portion 42. That is, The portions 42-1 and 42-2 are arranged so that the sealing portions 38-1, 38-2 and 38-3 on the side close to the second compartment of the inner container are connected to the opposite outer peripheral side portions (strong sealing portions) The lower compartment 30 and the discharge control chamber 40 are separated from each other and connected to each other. In other words, the upper portion 38-3 and both the side portions 38-1 and 38-2 of the weak seal portion 38 cooperate with the extension portions 42-1 and 42-2 of the steel seal 42 The second partition wall of the present invention for separating the second compartment 30 and the discharge control chamber 40 is constituted. Further, the inner bag 32 is divided into compartments 72 and 74, each of which houses therein the auxiliary medicament, by a weak seal portion 60 (an inner container dividing portion of the present invention) extending in the transverse direction 12).

14 shows another embodiment and has a lower end portion 10-1A having a narrowed width of the outer bag 10. This point is similar to the embodiment of Fig. 10, but the lower end portion 10-lA of Fig. And the inner pocket 32 (the outline overlapped with the strong seal portions 16 and 42 is indicated by a broken line) is accommodated in this portion 10-1. The inner pouch 32 has the sealing portions 38 (38-1, 38-2, 38-3 and 38-4) and the upper side 38- 3, the steel seal portion 42 is fixed to the inner surface of the inner bag 32 (the upper and lower compartments 72 and 74 are partitioned by the weak seal portion 60) facing the inner surface of the outer bag 10 One configuration is not different from Fig. 1 and other embodiments. Both ends of the upper portion 38-3 of the sealing portion 38 and the both side portions 38-2 of the right and left sides of the sealing portion 38 are formed in the outer bag 10 at the time of forming the steel seal portion 16 on the outer circumference of the outer bag 10, There is no difference in the structure for obtaining an oil-tight structure. In this embodiment, the width of the steel seal portion 16 is also the same at the fixed portions to the left and right side portions 38-2 of the sealing portion 38.

In the embodiment shown in Fig. 14, the inner pocket 32 is accommodated in the lower end portion 10-1A of the neck of the outer bag 10, so that the inner pocket 32 can be made compact, and the dimensional precision can be easily obtained. In addition, since the length of the upper and lower side portions 38-3 and 38-4 in the liquid circulation direction in the sealing portion 38 is shortened and the stress at the time of opening is more intensively applied, Easy and clear.

In the embodiment described above, the steel seal portion 42 is overlapped (overlapped) with the lower side compartment 30 and the upper side portion 38-3 of the inner side bag 32 at the sealing portion 38, The structure in which the steel seal portion 42 does not overlap with the upper portion of the seal portion 38 (the structure in which the opposed weld portion 42 in the steel seal portion 42 is not overlapped) 15 is basically the same as that of Fig. 1, and the inner pocket 32 is formed on the outer side Tight structure between the discharge chamber 40 of the lower compartment 30 and the oil seal portion 16 of the outer periphery of the bag 10 is obtained. 1, the strong seal portion 16 is not provided with the thickened portion 16-1, and both ends of the inner pocket 32 are stuck and sealed between the upper films constituting the strong seal portion 16, do. As in Fig. 1, the sealing portion (weak seal portion) 38 has left and right side portions 38-1 and 38-2 and upper and lower side portions 38-3 and 38-4. The inside of the inner pocket 32 is partitioned into left and right compartments 62 and 64 by the weak seal portion 60 in the longitudinal direction. The steel seal portion 42 as the external force applying means fixes the inner surface of the outer bag 10 to the opposite outer surface of the inner bag 32 like the other embodiments, Are arranged on the side of the compartment 30 so that they are almost or not overlapped at all. That is, as shown in Fig. 16, the upper and lower films 12 and 14 constituting the outer bag 10 and the upper and lower synthetic resin film pieces 34 and 36 constituting the inner bag 32 are strongly welded (34-1, 36-1). The synthetic resin film pieces 12 and 14 constituting the outer bag 10 are not welded to the synthetic resin film pieces 34 and 36 constituting the inner bag 32 in the sealing portion 38-3.

Fig. 17 is a cross-sectional view schematically showing the formation of the steel seal portion 42 by the seal mold in this embodiment in accordance with Fig. 7 (b). In the upper and lower dies 102 and 104 heated to a predetermined temperature, The first compartment 30 and the inner pouch 32 are narrowed and the second compartment 32 is sealed from the sealing portion 38-3 of the film pieces 34 and 36 constituting the inner pocket 32 with the outer bag 10 interposed therebetween. The extension ends 34-1 and 36-1 are pressed. The upper and lower dies 102 and 104 do not press the opposing faces of the outer bag 10 and the inner bag 32 from the extending ends 34-1 and 36-1 to the sealing portion 38-3. Therefore, the sealing portions 38-3 are welded to the opposing faces of the upper and lower film pieces 12 and 14 constituting the outer bag 10 so that the sealing portions 38-3 do not substantially overlap, The opposite inner surfaces of the end portions 34-1 and 36-1 are not welded in the high melting temperature layers), and the strong seal portion 42 is formed as an external force applying portion (Fig. 16).

In this embodiment as well, the external force caused by the expansion between the film pieces 12, 14 constituting the outer bag 10 at the time of unsealing is transmitted to the unsealing portion (not shown) via the edge portions 34-1, 38-3), it is possible to realize a reliable opening. In the case of a structure in which the steel seal portion 42 and the open portion 38-3 are overlapped with each other in the comparison of the welding structure in which the steel seal portion 42 and the open portion 38-3 as the external force applying portion are overlapped, In this embodiment, the tight seal portion 42 (thick solid line) and the tight seal portion 38-3 (thick broken line) are formed in the upper and lower portions, Are not overlapped or substantially do not overlap, it is possible to prevent the container from being excessively hardened locally.

18 is a modified embodiment of the embodiment of Fig. 8, in which the sealing portion (weak seal portion) 38 of the inner bag 32 has left and right side portions 38-1 and 38-2 and upper and lower side portions 38-3 and 38 -4). However, the inner pocket 32 is downsized so that the left and right widths are narrow, and the upper and lower side portions 38-3 and 38-4 do not reach the right and left strong seal portions 16, respectively. The steel seal portion 42 as the external force applying portion tightens the inner surface of the outer bag 10 to the outer surface of the inner bag 32 at the upper side portion 38-3 of the sealing portion 38. [ The portions 42A and 42B of the sealing portion 38 over the upper portion 38-3 of the sealing portion 38 extend to the steel sealing portions 16 on both the left and right sides of the outer bag 10, Respectively. (The second partition wall of the present invention) between the compartment 30 and the discharge control chamber 40 is such that the upper portion 38-3 of the sealing portion 38 of the inner bag 32 is separated from the upper portion Is extended to the steel seal portion 16 through the portions 42A and 42B for welding the upper and lower film pieces of the outer bag 10 in the outer case 42 and is integrally connected thereto. The portions 42A and 42B can be configured as weak seals for releasably welding the opposite inner surfaces of the outer bag 10. 3 and 7, the upper end portion 38-3 of the sealing portion 38 of the inner bag 32 is overlapped with the upper end portion 38-3 of the sealing portion 38, The state of oil-tight separation of the oil pan 40 can be ensured. 16, the sealing portion 38 of the inner bag 32 is formed so as not to overlap with the upper portion 38-3 of the sealing portion 38 of the inner bag 32, Liquid leakage occurs at the connection portion between the upper portion 38-3 of the upper seal portion 42 and the portions 42A and 42B of the strong seal portion 42 and the function as the second partition wall of the present invention is lost. (42, 38-3).

Fig. 19 shows a compartmented container according to the eighth embodiment, which is similar to the embodiment of Fig. 14, except that the shape of the chemical liquid bag is slightly different, and the outer bag 10 The shape of the welded portion 16-1 of the welded portion 16 is also different. That is, the strong welded portion 16-1 is formed so that the tip portion 16-1A having a narrow width from the steel seal portion 16 on the outer periphery of the outer bag 10 toward the inner pocket 32 is positioned above the inner pocket 32 30) side to the corner. The connection portions between the left and right side portions 38-1 and 38-2 and the upper side portion 38-3 of the weak seal portion 32 of the inner bag 32 are fastened to each other by the welded portion 16-1, (Not shown). The inner bag 32 is basically free from the outer bag 10 on the side of the discharge port 18 from the tip 16-1A. The inner bag 32 is disposed at both ends of the lower side 38-4, And is fixed to the outer bag 10 by the point seal portions 44-1 and 44-2 so as to sandwich the discharge port 18. [ That is, the upper and lower film surfaces of the outer bag 10 can not be peeled off from the local portion indicated by reference numerals 44-1 and 44-2 on the lower side portion 38-4 of the weak seal portion 38 of the inner bag 32 . 14 and the inner bag 32 form a rectangular shape elongated in the width direction of the outer bag 10 and the interior thereof is surrounded by upper and lower compartments 72 and 74 by a weak seal portion 60 as an inner container dividing portion. Respectively. By providing the point sealing portions 44-1 and 44-2 on both sides, it is easy to widen the film constituting the opening 48-5 at the time of mounting the discharge port 18 described in Figs. 6 (d) and 6 (e) So that it is possible to more easily and reliably insert the discharge port 18 into the predetermined position.

Next, a method of manufacturing the inner bag 32 in the eighth embodiment will be described. In Fig. 20 and Fig. 21, the cylindrical sheet-like material 80 constituting the inner bag 32 is rolled R). 22 schematically shows a cross-sectional shape of the film F constituting the sheet-like material 80. One surface of the polyethylene base layer F ₁ made of a multilayer polyethylene film (the inner surface of the inner bag 32) the layer) (to form a C0P) layer (F _2), the other side (anjumeoni 32 cyclic polyolefin-based resin can be peeled off the protective film (F ₃₎ consisting of a polyamide resin (nylon) in the layer which is the outer surface of) Respectively. As shown in Fig. 20, driving portions 82-1 and 82-2 for pulling out the sheet-like material 80 from the roll R are provided on the downstream side. The driving units 82-1 and 82-2 are provided with suitable driving devices and are configured to control the drawing movement of the sheet material 80 from the roll R in a predetermined period. The polyethylene base layer F ₁ constituting the film F, the cyclic polyolefin resin (COP) layer F ₂ and the polyamide resin layer F ₃ constituting the protective film during the inflation of the material 80 But the polyamide resin layer F ₃ is not affinity enough to be integrated with the base layer F ₁ , but inflation is performed by maintaining mutual adhesion (which can be peeled off) . For this reason, the polyamide resin layer (protective film) F ₃ is kept adhered to the cylindrical sheet-like material 80 in the process of molding the sachet chain product described below. The protective film (F ₃ ) is not particularly limited as long as it is a resin having a weak affinity with the polyethylene base layer, and polypropylene, ethylene vinyl alcohol copolymer and the like may be used.

23 schematically shows the cross-sectional shape of the sheet-like material 80 immediately after being drawn out from the roll R and has a flat shape but closed at both ends. The inner surface of the sheet- there is a cyclic polyolefin resin (COP) layer (F ₂₎ in Fig.

As shown in FIG. 20, center sealing devices (molds) 86-1 and 86-2 are disposed between the guide rollers 84 and 85, the still sheet-like material (78) sealing the mold (86-1,86-2), the center of the inner surface by polymer, as shown (cyclic polyolefin-based resin (COP) layer (F ₂₎₎ to the width direction in FIG. 24 (Approximately sealed) in a predetermined width. By the movement of the heating molds 86-1 and 86-2 by the length of the heating surface in the open state and the subsequent sealing by the combination of the sealing dies 86-1 and 86-2, The weak seal portion (center seal) 80A is formed over all lengths along the center line of the sheet-like material 78 and becomes the weak seal portion 60 of the small pouch 38 in Fig. About the seal temperature of the center seal cyclic polyolefin-based resin to form the (80A) (COP) layer (F ₂₎ is on the order of 180 ℃ as described above in connection with the embodiment of the figure.

The cutter 88 is disposed downstream of the guide roller 84-2 and both ends of the sheet material 80 in the width direction are cut off by the cutter 88. The sheet material 80 is cut on both sides The opening portions 80B-1 and 80B-2 are formed as shown in Fig.

20, circular main column bodies (columnar main body 90-1, 90-2) extending along the moving direction of the sheet material 80 (a convex surface And the main body 90-1 and 90-2 are disposed on both sides of the sheet material 80 through openings 80B-1 and 80B-2 of the sheet material 80 And is inserted and positioned in the sheet material 80 along the center seal 80A (see also Fig. 26 (a)). Injection nozzles 92-1 and 92-2 are inserted and fixed over the entire length along the center line of the tub-shaped main body 90-1 and 90-2. The upper ends of the liquid nozzles 92-1 and 92-2 are connected to the liquid medicine supply lines 93-1 and 93-2 (Fig. 21), and the medicine supply lines 93-1 and 93-2 are connected to the sheet- 2 extend outward from the openings 80B-1 and 80B-2 of the housing 80 and are connected to respective drug supply sources (tanks, pumps, etc.) (not shown). Side seal dies 94-1 and 94-2 are disposed to sandwich the liquid body 90-1 and 90-2 with the sheet-like material 80 interposed therebetween. As shown in Fig. 26 (a), the seal dies 94-1 and 94-2 are formed in the shape of a concave shape having substantially the same shape as the upper and lower halves of the outer diameter of the liquid main bodies 90-1 and 90-2, 94-lA, 94-lB; 94-2A, 94-2B. The concave surfaces 94-1A and 94-1B; 94-2A and 94-2B extend from the upper surface to the lower surface of the molds 94-1 and 94-2 as shown in FIG. As shown in Fig. 26, both sides of the concave surfaces 94-1A, 94-1B; 94-2A and 94-2B in the molds 94-1 and 94-2 are flat surfaces 94-1C and 94- 2C. The flat surfaces 94-1C and 94-2C seal both sides of the sheet-like material 80. The sheet- As shown in Fig. 20, seal molds 95-1 and 95-2 for crossing are provided at positions below the side seal molds 94-1 and 94-2 (positions separated by the length of one drug seal) .

26A shows the open positions of the seal dies 94-1 and 94-2 and Fig. 26B shows the positions of the seal dies 94-1 and 94-2 from the position of Fig. 26A, As shown in Fig. The side seals 80C-1 and 80C-2 (see FIG. 19) are attached to the sheet-like material 80 by the flat surfaces 94-1C and 94-2C of the sheet- The upper and lower side portions 38-3 and 38-4 in the weak seal portion 38 of the inner bag 32 are formed) and the seal dies 95-1 and 95-2 are combined Thereby forming a cross seal 80D (left and right side portions 38-1 and 38-2 in the weak seal portion 38 of the inner bag 32 of Fig. 10) in the sheet-like material 80 . The concave surfaces 94-1A and 94-1B; 94-2A and 94-2B of the molds 94-1 and 94-2 are positioned above and below the outer diameter of the instilling body 90-1 and 90-2, The sheet-like material 80 is in contact with the concave surfaces 94-1A and 94-1B (94-2A and 94-2B) and the outer diameter of the fluid body 90-1 and 90-2 if it is blocking between the surface and also because the concave receiving the heating at about the sealing temperature of about 180 ℃ of the cyclic polyolefin-based resin (COP) layer _{(F 2) (94-1A, 94} -lB; 94-2A, 94-2B ) In accordance with the curved shape. Therefore, the sheet-like material 80 has a concave surface 94-1A, 94-1B (94-2A, 94-2A, 94-2A) as shown in Fig. 27, And 80E-2 having a length corresponding to the length of the sealing molds 94-1 and 94-2 are formed in a convex shape in accordance with the curved shape of the sealing molds 94-1 and 94-2B. The cavity portions 80E-1 and 80E-2 become upper and lower compartments 72 and 74 in the weak seal portion 38 of the inner bag 32 of FIG.

The movement of the sheet material 80 by the driving portions 82-1 and 82-2 and the sealing action by the sealing molds 94-1 and 94-2 and 95-1 and 95-2 When the sheet-like material 80 is stopped and the sealing dies 94-1 and 94-2 are inserted in the state shown in Fig. 26 (b) with the medicine supply pipes 93-1 and 93-2 interposed therebetween, To form the side seals 80C-1 and 80C-2 by the surfaces 94-1D and 94-2D, respectively. The sheet material 80 is stuck between the concave surfaces 94-1A and 94-1B; 94-2A and 94-2B and the outer surface of the main body 90-1 and 90-2, And is set in a convex surface shape corresponding to the curved shape. Further, at positions downstream from the seal dies 94-1 and 94-2 by the length of one drug seal, the seal dies 95-1 and 95-2 are combined to form the cross seal 80D . Then, the sealing dies 94-1, 94-2 and 95-1, 95-2 are split right and left as shown in Fig. At this time, the cross seal 80D is moved to the previous sealing mold 95 (or 95E-1 and 80E-2) connected to the cavities 80E-1 and 80E-2 newly formed and divided by the combination of the sealing dies 95-1 and 95-2 -1, 95-2), the bottoms of the cavities 80E-1 and 80E-2 partitioned by the coalescence are closed. The jointed portions 80E-1 and 80E-2 are still open on the top side and the lower ends 92-1A and 92-2A of the instilling nozzles 92-1 and 92-2 are opened And the cavity portions 80E-1 and 80E-2 are opened (Fig. 21). In the cavity portions 80E-1 and 80E-2, the upper ends of which are still open, the medicines 96-1 and 96-2 are supplied from the respective drug supply sources (pumps, etc.) to the injection nozzles 92-1 and 92- 2 by a predetermined amount from the lower ends 92-1A and 92-2A. Then, the sealing dies 94-1, 94-2, 95-1, 95-2 are combined again, and the cross seals 80D are formed by the combination of the sealing dies 95-1, 95-2 However, the cross seal 80D is provided with the cavities 80E-1 and 80E-2 formed by the combination of the sealing molds 95-1 and 95-2 for the previous time, in which the injection of the medicines 96-1 and 96-2 is completed, 80E-2 are closed, and the bottom, side, and one drug seal portion sealed around the entire periphery of the column are formed. On the other hand, by the combination of the sealing molds 94-1, 94-2, And 80C-2 are formed, and new cavities 80E-1 and 80E-2 having upper openings are formed, and by repeating the same operation, A plurality of medicament-packed chain members M (hereinafter referred to as " inner cartilage chain members "

Anjumeoni chain body (M) is less than the adhesive on both surfaces a protective film (F ₃₎ table as described in Figure 23, the state in Figure 5 and is transferred to the manufacturing facility for performing the process, acid-type container of FIG. The protective film F ₃ can prevent foreign matter adherence and sterility of the inner sachet chain member M during the transferring process. And, FIG peeling a protective film (F ₃₎ in anjumeoni chain body (M) during the conduct of 5 the manufacturing process of the compartmented container, followed by complete removal as a anjumeoni 32 by cutting in the middle the cross seal (80D) And the inserting pouch 32 can be inserted as described in Fig. 5 (b).

10: outer bag (outer container of the present invention)
12, 14: Film pieces constituting the outer bag
16: Steel seal part
16-1: Widening part of the strong seal part 16 (connection part of the present invention)
18: Outlet
20: Honjugu
28: weak seal portion (first partition wall of the present invention)
32: Inner pouch (inner container of the present invention)
34,36: Film pieces constituting the inner bag
34-1, 36-1:
38: Seal part of outer circumference of inner bag
38-1, 38-2: left and right sides of the weak seal portion
38-3, 38-4: upper and lower sides of the weak seal portion
40: Exhaust control chamber
42: Steel seal part (Whether the external force of the present invention is attached)
42 ': welded portion of the edge portion
44: Point sealing portion (whether auxiliary external force applying portion of the present invention)
80: sheet-like material
80A: Center seal
80B-1, 80B-2:
80C-1, 80C-2: side seal
80D: Cross seal
80E-1 and 80E-2:
82-1 and 82-2:
86-1, 86-2: Center seal mold
88: Cutter
90-1, 90-2:
92-1, 92-2: Injection nozzle
93-1, 93-2: drug injection tube
94-1, 94-2: Side seal mold
95-1, 95-2: Sealing tool for cross

Claims (22)

An outer container formed from a flexible film and formed into a bag-like shape; a discharge port fixed to the outer peripheral portion of the outer container for discharging the medicine; and an inner portion of the outer container separated from the discharge port, A second partition wall partitioning the inside of the outer container on the side close to the discharge port and being openable by an external force to an outer container larger than an external force for opening the first partition wall, A first compartment formed inside the outer container at a gap side from the discharge port of the first liquid medicament and containing a first liquid medicament and a second compartment formed inside the outer container between the first partition and the second partition, A discharge compartment formed in the outer container between the second compartment and the discharge port or in communication with the discharge port, An inner container disposed on the inner side of the discharge control chamber on the side close to the discharge port of the second compartment and having an encapsulating portion accommodating the auxiliary medicament and being capable of being opened along the outer periphery; And an external force applying unit for attaching the external force to the inside surface of the inner container to apply an external force for opening the sealing portion of the inner container. The container according to claim 1, wherein the second partition has a sealing portion at a side close to the second compartment of the inner container, and a sealing portion at a side close to the second compartment of the inner container, A compartmentalized container comprising a connection portion for connection to separate the discharge control chamber. 3. The compartmental container according to claim 2, wherein the connecting portion is a steel seal portion which is welded integrally with the sealing portion of the inner container and is an outer peripheral portion of the outer container. 4. A compartmental container according to claim 3, wherein a proximal side of the sealing portion of the inner container with the second compartment extends to near full width of the outer container. 5. The compartmental container according to claim 4, wherein both side portions of the sealing portion of the inner container are integrally connected to the steel sealing portion on the outer periphery of the outer container which is the connecting portion of the connecting portion. 3. The container according to claim 2, wherein the connecting portion is formed by connecting both ends close to the second compartment of the sealed portion of the inner container and a steel seal portion on the outer periphery of the outer container facing the sealed portion, Mrs. 3. The compartmental container according to claim 2, wherein the external force applying portion is disposed along the sealing portion on the side close to the second compartment of the inner container. 8. The compartmental container according to claim 7, wherein the fixed portion of the inner container to the opposite inner surface of the inner container at the external force applying portion extends to some extent from the sealing portion of the inner container toward the second compartment. 9. The compartmental container according to claim 8, wherein the fixed portion of the inner container to the opposite inner surface of the outer container at the external force applying portion is substantially not overlapped with the sealed portion of the inner container. 10. The compartmental container according to any one of claims 1 to 9, wherein the external force applying portion is installed to extend along substantially all of a width on a side close to the second compartment in the sealing portion of the inner container. 10. The compartmental container according to any one of claims 1 to 9, wherein the outer container has a narrowed shape at the discharge port side in the second compartment, and the inner container is provided at a portion where the width of the outer container is narrowed. 10. The compartmental container according to any one of claims 1 to 9, further comprising an auxiliary external force applying portion for locally securing the separated side of the sealed portion of the inner container with the second compartment to the opposite surface of the outer container. 13. The compartmental container according to claim 12, wherein the auxiliary external force applying portion is formed in a pair with the discharge port therebetween. 10. The compartmental container according to any one of claims 1 to 9, wherein the inner container has an inner container dividing portion into a plurality of compartments. 10. A container according to any one of claims 1 to 9, wherein the inner container is a releasable seal by peelably welding the flexible film piece to opposite surfaces, while the outer surface of the inner container is opposed to the outer container And an outer force imparting portion by melting and releasing the inner surface in a non-releasable manner. 16. The method according to claim 15, wherein the flexible film constituting the inner container has a multilayer structure including a layer made of a resin having a low melting temperature and a layer made of a resin having a high melting temperature, Wherein the external force application portion is constituted by fusion of opposing surfaces of the high melting temperature layer in the opposing flexible film pieces, and the external force application portion is formed by melting a layer of the low melting temperature in the flexible film piece, . 10. The compartmental container according to any one of claims 1 to 9, wherein the flexible film constituting the inner container has a heat-formed concave portion for partitioning the cavity portion for receiving the medicine. The method for sealing a compartment container according to any one of claims 1 to 9,
Preparing an inner container in which an outer container with an outer periphery is not formed at the side of the compartment and an auxiliary medicament is received in the compartment and the outer periphery is sealed by a sealing portion, And the outer surface of the flexible film in the sealed portion of the inner container is welded to the opposite inner surface of the flexible film constituting the outer container on the side close to the compartment, thereby forming the external force applying portion. The method according to claim 18, wherein the flexible film constituting the inner container has a multilayer structure, and has a layer with a low melting temperature and a layer with a high melting temperature, and the sealing portion of the inner container has a high melting temperature The outer surface of the inner container and the outer surface of the inner container at the low melting temperature of the inner container are bonded to each other without being welded to each other by the stitches between the pair of heating surfaces of the seal mold. Thereby forming an external force applying portion. 10. A method of manufacturing an inner container in a compartmented container according to any one of claims 1 to 9,
The center of the flattened bag-shaped film sheet in the width direction is peelably center-sealed, both ends of the bag-like film sheet are cut off, and the injection nozzle is inserted through the sheet opening so as to follow the center seal. , A bottom seal is formed by peeling the bottom seal so that the bottom seal can be peeled off from the sheet, and a predetermined amount of medicament is injected into the cavity after the medicament is fed to the sheet after the medicament is injected By repeating the respective steps of forming the partition of the cavity closed at the bottom and the cavity opened at the bottom and injecting the medicine after the sheet transfer and the top closure by the cross seal after the closing of the top side of the cavity portion, Forming a chained body of a live part, cutting out one medicament-packed part from the chained body Wherein the inner container is made of an inner container. 21. The manufacturing method of an inner container according to claim 20, wherein a protective film is adhered to the surface of the bag-like film sheet which becomes the outermost surface when the inner container is used, and peeled off before the inner container is attached to the outer container. 21. The manufacturing method of an inner container according to claim 20, wherein the film is pressurized by a seal mold at an outer diameter portion of the injection nozzle at the time of sealing, and the film portion forming the cavity portion is formed by heating to form a convex surface.

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