CN202236306U - Multilayer co-extrusion transfusion double-chamber bag - Google Patents
Multilayer co-extrusion transfusion double-chamber bag Download PDFInfo
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- CN202236306U CN202236306U CN2011203224468U CN201120322446U CN202236306U CN 202236306 U CN202236306 U CN 202236306U CN 2011203224468 U CN2011203224468 U CN 2011203224468U CN 201120322446 U CN201120322446 U CN 201120322446U CN 202236306 U CN202236306 U CN 202236306U
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Abstract
The utility model provides a multilayer co-extrusion transfusion double-chamber bag, which comprises a bag body, a transfusion container interface and a cover which are sequentially connected, wherein the bag body is made of a multilayer co-extrusion transfusion membrane; the middle part of the bag body is provided with a plurality of easily opened cold solder joint regions; unsolder transition regions are arranged among the cold solder joint regions; the bag body is divided into a lower chamber and an upper chamber by the cold solder joint regions; and the lower chamber is connected with the transfusion container interface. The multilayer co-extrusion transfusion double-chamber bag provided by the utility model is provided with two easily opened cold solder joint regions and the structure of the transition region in the middle of the two easily opened cold solder joint regions can prevent opening of double chambers of powder and solution during storage and transportation. By using pillow type package, opening is avoided, space is saved and meanwhile aerial delivery can be allowed during storage and transportation.
Description
Technical field
This utility model belongs to the medical packaging field, is specifically related to a kind of multi-layer co-extrusion infusion with two chambers bag.
Background technology
Transfusion has the following advantages with two chambers bag: 1), contrast with the glass infusion vessel, this packaged form and drug compatibility meet the requirements, and no medicinal liquid seepage to thermally-stabilised, does not influence transparency; Extremely low to water vapour and gas-premeable, can keep the concentration stabilize of infusing, guarantee the storage life of product.2), process two chambers bag of different size, solved the difficult problem of clinical application, also made things convenient for clinical use according to clinical needs.3), two chambers bag also can alleviate the pressure of its offal treatment in clinical use, the minimizing environmental pollution.4), avoided the complex operations when transfusion mixes before the clinical use in the prior art, reduced secondary pollution.The situation of mismatch medicine when 5), having avoided in case of emergency using.
Existing transfusion pack bag, infusion vessel interface and the lid that the multilayer co-squeeze film for transfusion that mainly comprises connection is successively processed with two chambers bag; Said bag is divided into two chambers through the isolation structure that is prone to open, and often there is the bad or problem such as operation inconvenience when opening of seperating safety in the isolation structure that is adopted.For example notification number is that the Chinese patent of CN2680274 discloses a kind of powder and liquid double-chamber transfusion flexible bag (patent No.: 200420039029.2); At first to have only a side be aluminum membranous layer in bag chamber on it; Opposite side is the transparent obstructive thin layer; From the protection medicine stability, this packing can not be stopped the harmful effect that illumination produces medicine fully.Secondly there is an easy-opening heat-sealable area bag middle part, and bag is divided into liquid chamber and upward a bag chamber down; This heat-sealing is in confused situation, and heat-sealing imprecision or not anti-certain pressure powder liquid two Room have just taken place between transportation, storage life easily opened and dissolve, and the initial safety that has lost powder and liquid double-chamber bag is isolated purpose.
The utility model content
In order to address the above problem, this utility model provides a kind of multi-layer co-extrusion infusion with two chambers bag.
The multi-layer co-extrusion infusion that this utility model provides is with two chambers bag; Comprise successively bag, infusion vessel interface and lid that the multilayer co-squeeze film for transfusion that connects is processed; Wherein, the middle part of said bag has the rosin joint district that multiple tracks is prone to open, and is provided with the transition region of not seam between the said rosin joint district; Said rosin joint district is divided into chamber and last chamber down with said bag, and said chamber down connects said infusion vessel interface.
Enumerate the preferred technique means that some can be selected for use below.
Said rosin joint district is twice.
Said rosin joint district is formed by the heat seal line heat seal.
The bag that said multilayer co-squeeze film for transfusion is processed is followed successively by polypropylene (PP) layer, multi-component copolymer polypropylene (PP) and thermoplastic elastomer (TPE) graft copolymer (TPO) layer and polypropylene layer from outside to inside.This three-decker is a known configurations.
Said infusion vessel interface is the plastic container for infusion interface of processing with polypropylene.
The composite cover that said lid is made up of draw-ring type enclosing cover, inner cap and pad, said draw-ring type enclosing cover and inner cap all are raw material with the polypropylene, and said pad is the polyisoprene material.
The skin of said bag also is provided with aluminium foil layer.
Said aluminium foil layer is sealed the said chamber of going up fully.
Respectively there is a suppending hole said both sides, top of going up the chamber.
Said chamber down and the said chamber of going up are equipped with medicinal liquid and medicated powder respectively, and said chamber down and the said chamber of going up are pillow type packaging, and said pillow type packaging is meant that said chamber down and the said chamber of going up fold along said transition region.
The multi-layer co-extrusion infusion that this utility model provides has the following advantages with two chambers bag:
1), rosin joint is isolated the position: twice are prone to open the rosin joint district, and the centre is provided with a transition region, prevent that powder and liquid double-chamber is open-minded in storage, the transportation.
2), aluminum film welding position: adopt front-back two-sided aluminum film welding, resistance oxygen, separated wet, good seal performance.
3), pillow type packaging: under the mal-condition, in storage and the transportation, avoid open-minded, and save the space; Can drop simultaneously.
4), do not contain softening agent ethyl phthalate (DEHP), binding agent and plasticizer, reduced potential safety hidden danger.
5), in case of emergency, for the urgent patient, pressurization is used, and does not need bubbling air again in the infusion process, easily and fast, has avoided potential secondary pollution simultaneously, makes transfusion safer.
Description of drawings
Fig. 1 is that a kind of multi-layer co-extrusion infusion that this utility model provides is used pair structural representation of chambers bag;
Fig. 2 is that multi-layer co-extrusion infusion shown in Figure 1 is used the structural representation after two chambers bag tears aluminium foil layer off;
Fig. 3 is the cutaway view that multi-layer co-extrusion infusion shown in Figure 1 is used two chambers bag;
Fig. 4 is the vertical view of the multi-layer co-extrusion infusion of the pillow type packaging that provides of this utility model with two chambers bag;
Fig. 5 is the side view of the multi-layer co-extrusion infusion of pillow type packaging shown in Figure 4 with two chambers bag.
Among the figure:
1, polypropylene combination cover
2, plastic container for infusion interface
3, following chamber (liquid chamber)
4, real welding zone
5, rosin joint district
6, go up chamber (solids chamber)
7, suppending hole
8, aluminium foil layer
9, transition region
The specific embodiment
Shown in Fig. 1-3; This multi-layer co-extrusion infusion comprises plastic container for infusion interface 2 with two chambers bag; Polypropylene combination cover (draw-ring type) 1; The bag that multilayer co-squeeze film for transfusion is processed (with three layers is example: ground floor is high strength, high transparent polypropylene (PP), and the second layer is multi-component copolymer polypropylene (PP) and thermoplastic elastomer (TPE) (TPO) graft copolymer, and the 3rd layer for sealing copolymerized type propene polymer at a high speed).Bag is transparent; The draw-ring type polypropylene combination cover 1 of one end; Supply perforator to set up service aisle, the periphery of bag is a real welding zone (sealing strip) 4, and the bag middle part has twice to be prone to open the rosin joint district 5 of two Room; Per pass rosin joint district forms by 4-5 bar heat seal line, and twice rosin joint district can guarantee that sealing can conveniently open use again under the situation of exerting pressure.One transition region 9 is arranged in the middle of this rosin joint district, and rosin joint district 5 is divided into chamber (liquid chamber) 3 and upward chamber (solids chamber) 6 down with transition region 9 with described bag; Following chamber (liquid chamber) 3 can supply the fill venous transfusion with 0.9% sodium chloride injection or other medicinal liquids, and last chamber (solids chamber) 6 can supply the aseptic powder of fill all size and each kind; Aluminium foil layer 8 will be gone up chamber (solids chamber) 3 two-sided sealing, and end to that rosin joint district, road lower edge 2-5mm near last chamber the position of sealing; Respectively there is a suppending hole 7 both sides, 6 upper end, chamber on the bag (solids chamber), supply the vertical hanging multi-layer co-extrusion infusion with two chambers bag.
Fig. 4 and Fig. 5 have represented the multi-layer co-extrusion infusion of pillow type packaging with two chambers bag, and said pillow type packaging is meant that said chamber down and the said chamber of going up fold along said transition region.
Explain further details in the face of said structure down.
Said multi-layer co-extrusion infusion comprises bag, plastic container for infusion interface, polypropylene combination cover three parts that multilayer co-squeeze film for transfusion is processed with two chambers bag.Series of work stations runnings such as its manufacturing process is mainly film, rosin joint, all side welds, joint weld, tears slitter edge, bag transmission, vacuum leak hunting, fill, composite cover welding, sterilization, aseptic subpackaged, lamp inspection, the welding of aluminum film; Wherein bag-making loading, aseptic subpackaged all automatization's completion under A level cleanliness class with three portion of hot integrators, are one-shot formings, prevent that effectively manual operation from polluting, and be time saving and energy saving, cuts the waste.(solids chamber) fill medicated powder finishes in last chamber, and aluminium foil layer is all welded on the two sides, makes the complete shading in chamber, and increases sealing property.The folding pillow type packaging of placing can be anti-extrusion, and is anti-drop.
Described multilayer co-squeeze film for transfusion is known novel infusion pharmaceutical pack material; With three layers is example: ground floor is high strength, high transparent polypropylene (PP); The second layer is multi-component copolymer polypropylene (PP) and thermoplastic elastomer (TPE) (TPO) graft copolymer; The 3rd layer at a high speed sealing copolymerized type propene polymer, and the characteristics of film are: nontoxic, high resistant wet, high resistant oxygen, high temperature resistant, height is transparent, pliability good, low temperature resistivity strong (40 ℃), heat sealing strength height, environmental protection.Its function is: process bag, as the container that takes up medicine.
Said plastic container for infusion interface (for known) is a primary raw material with the polypropylene, and be characterized in: thermal adaptability is good, after 121 ℃ of sterilizations, does not ftracture, indeformable; Anti-drop, highly fall from 1.2m and not break; Detect particulate matter, its >=particle of 5 μ m is no more than 100/ml, and the particle of >=10 μ m is no more than 20/ml, and the particle of >=25 μ m is no more than 2/ml, and leachable experiment and biologic test result all are applicable to as the pharmaceutical pack material.Its function is: as the fill passage of sap cavity chamber, be the important link that connects composite cover and bag.
Said polypropylene combination cover is made up of draw-ring type enclosing cover, inner cap and pad.Draw-ring type enclosing cover and inner cap are primary raw material with the polypropylene all, and pad is the polyisoprene material, meets the YBB00232004 standard.The polypropylene combination cover for plastic infusion container function of draw-ring type is: supply perforator to set up service aisle.
Described bag middle part has twice to be prone to open the rosin joint district of two Room.This is the remarkable advantage of this utility model; The following chamber (liquid chamber) that it is divided into bag reaches goes up chamber (solids chamber); Following chamber (liquid chamber) supplies the fill venous transfusion with 0.9% sodium chloride injection or other medicinal liquids; Last chamber (solids chamber) supplies the fill aseptic powder, and is oxidized if this aseptic powder is prone to, and can also carry out nitrogen filled protection to last chamber (solids chamber) through the equipment operation.The per pass rosin joint grows to all side weld inward flanges, form by the heat seal of bar heat seal line, the rosin joint district the pressure that can bear, can resist the external force extruding of processes such as transportation in conjunction with the pillow type packaging form, can guarantee that also the people conveniently opens two Room for pushing when clinical application.Be provided with wide, as to grow to an all side weld inward flanges transition region in the middle of the twice rosin joint district, transition region plays cushioning effect not by heat seal.
Said multi-layer co-extrusion infusion is real weldering with all side welds of two chambers bag, and heat and intensity are high, and bag is sealed fully.
The periphery on two sides outside the bag of last chamber (solids chamber), described aluminium foil layer welding position; To go up the chamber seals fully; Aluminium foil has shading, resistance oxygen, at a distance from performance wet, sealing, can be further effectively protection go up the aseptic powder of chamber (solids chamber), prevent its moisture absorption, oxidized, illumination decomposition, go bad.
The described multi-layer co-extrusion infusion of this utility model can adopt pillow type packaging with two chambers bag, and its two Room is at the middle part when folding, renitency at least, and two Room can not be by open-minded, all is folding the placement in physical holding of the stock and the transportation, uses dustproof plastic bag to carry out outer package.Before the clinical use, take dustproof plastic bag apart, after folding multi-layer co-extrusion infusion is launched with two chambers bag, can realize that by depressing chamber (liquid chamber) two Room are open-minded with hands, moment dissolved substance, make things convenient for clinical application, very convenient, practical, reasonable.
Respectively there is a suppending hole the described both sides, top, chamber (solids chamber) of going up, and the vertical hanging multi-layer co-extrusion infusion is with two chambers bag when supplying to use.
Said multi-layer co-extrusion infusion with two chambers bag advantage is:
Ease for use: convenient clinical use, simplify the transfusion device connection procedure, the unique design in rosin joint district, extruding can realize that just two Room are open-minded in chamber (liquid chamber) down, makes medicine moment dissolving; Plasticity is good, the convenient high capacity medicinal liquid that adds; Pliability is strong, and anti-sterilization is shock-resistant anti-drop; In use, can rely on the tension force of self that the medicinal liquid compressing is oozed, also can cooperate pressure transfusion, need not bubbling air again, avoid potential secondary pollution.
Safety: drug resistance is good, and inertia is good, does not contain binding agent and plasticizer, with medicine generation chemical reaction, does not have no side effect; The two-sided aluminium foil layer welding in last chamber, resistance oxygen, separated wet, good airproof performance, closed transfusion is avoided forming air embolism and is caused air pollution; Transparency is good, makes things convenient for preoperation inspection drug residue and pollution hidden trouble.
The feature of environmental protection: no poisonous and harmful substance produces in the manufacture process, and the useless bag in practical back is long-pending to reduce 80%, does not produce harmful gas during burning, and the monomer of material own is biodegradable, the buried destruction Soil structure that do not pollute the environment.
Economical: technology is advanced, and bag-making loading automatization under A level cleanliness class accomplishes, and effectively prevents to pollute, and cuts the waste, and volume is little, in light weight, the unique design of pillow type packaging is convenient to store, transports, saves the space, can be dropped.
Said multi-layer co-extrusion infusion is with the medicine inspecting institute's detection through Beijing of two chambers bag, and all test items are all up to specification.
Said multi-layer co-extrusion infusion detects with the rosin joint district heat sealing strength of two chambers bag: with multi-layer co-extrusion infusion with two chambers bag in-25 ℃ ± 2 ℃ condition held 24 hours; Under 50 ℃ ± 2 ℃ conditions, continue then to place 24 hours; Under 23 ℃ ± 2 ℃ conditions, continue to place 24 hours again, take out.Sample is folded and placed between two parallel-plates, can bears 44.3Kpa pressure, kept 10 minutes, rosin joint does not have cracking; Sample two Room are launched, place between two parallel-plates, when external pressure increased to scope, twice rosin joint district was open-minded, realized medicine dissolution.
Described aluminium foil sweating heat and intensity detection: the welding position is cut 5 on the wide sample of 15.0 ± 0.1mm; Materials; With the heat seal position is the center, opens to be 180 °, is clipped in the two ends of sample on two anchor clamps of tensiometer; The sample axis should coincide with last lower clamp centrage, and requires degree of tightness suitable.Spacing jig is from being 50mm, and test speed is 300 ± 20mm/min, the maximum load when reading sample fracture.The meansigma methods of each 5 sample in aluminium foil sample heat seal position is as the heat sealing strength of this aluminium foil sample, and unit is N/15mm, and the meansigma methods at aluminium foil and multilayer co-squeeze film for transfusion heat seal position all is not less than 0.5.
Described aluminium foil steam penetrating capacity detects: select 3 on the sample of smooth no visual defects, cut with disk sampling cutter respectively, specimen finish should be between cup ring diameter and cup diameter.According to plastic sheeting and sheet material water vapor permeability test method---the regulation of cup type method is carried out.Heat cover is to the low side of humidity, 38 ± 2 ℃ of test temperatures during test.Coupon results is with the arithmetic average value representation of three samples, and the deviation between sample measured value and the arithmetic mean of instantaneous value is no more than ± and 10%.Steam penetrating capacity is no more than 0.5g/ (m
224h).
The anti-drop detection of this utility model pillow type packaging:, under 50 ℃ ± 2 ℃ conditions, continue then to place 24 hours, again under 23 ℃ ± 2 ℃ conditions in-25 ℃ ± 2 ℃ condition held 24 hours; Continue to place 24 hours, take out, the pillow formula is folding; Then from the 1.00m height; Fall respectively on the inflexible smooth surface of a hard, do not break and do not leak, and two rosin joints of sample do not ftracture.
Claims (10)
1. multi-layer co-extrusion infusion is with two chambers bag; Comprise successively bag, infusion vessel interface and lid that the multilayer co-squeeze film for transfusion that connects is processed; It is characterized in that the middle part of said bag has the rosin joint district that multiple tracks is prone to open, be provided with the transition region of not seam between the said rosin joint district; Said rosin joint district is divided into chamber and last chamber down with said bag, and said chamber down connects said infusion vessel interface.
2. multi-layer co-extrusion infusion according to claim 1 is characterized in that with two chambers bag said rosin joint district is twice.
3. multi-layer co-extrusion infusion according to claim 1 is characterized in that with two chambers bag said rosin joint district is formed by the heat seal line heat seal.
4. multi-layer co-extrusion infusion according to claim 1 is characterized in that with two chambers bag the bag that said multilayer co-squeeze film for transfusion is processed is followed successively by polypropylene layer, multi-component copolymer polypropylene and thermoplastic elastomer (TPE) graft copolymer layer and polypropylene layer from outside to inside.
5. multi-layer co-extrusion infusion according to claim 1 is characterized in that with two chambers bag said infusion vessel interface is the plastic container for infusion interface of processing with polypropylene.
6. multi-layer co-extrusion infusion according to claim 1 is with two chambers bag; It is characterized in that; The composite cover that said lid is made up of draw-ring type enclosing cover, inner cap and pad, said draw-ring type enclosing cover and inner cap all are raw material with the polypropylene, and said pad is the polyisoprene material.
7. multi-layer co-extrusion infusion according to claim 1 is characterized in that with two chambers bag the skin of said bag also is provided with aluminium foil layer.
8. multi-layer co-extrusion infusion according to claim 7 is characterized in that with two chambers bag said aluminium foil layer is sealed the said chamber of going up fully.
9. multi-layer co-extrusion infusion according to claim 1 is characterized in that with two chambers bag respectively there is a suppending hole said both sides, top of going up the chamber.
10. multi-layer co-extrusion infusion according to claim 1 is with two chambers bag; It is characterized in that; Said chamber down and the said chamber of going up are equipped with medicinal liquid and medicated powder respectively, and said chamber down and the said chamber of going up are pillow type packaging, and said pillow type packaging is meant that said chamber down and the said chamber of going up fold along said transition region.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011203224468U CN202236306U (en) | 2011-08-30 | 2011-08-30 | Multilayer co-extrusion transfusion double-chamber bag |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011203224468U CN202236306U (en) | 2011-08-30 | 2011-08-30 | Multilayer co-extrusion transfusion double-chamber bag |
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| Publication Number | Publication Date |
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| CN202236306U true CN202236306U (en) | 2012-05-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011203224468U Expired - Lifetime CN202236306U (en) | 2011-08-30 | 2011-08-30 | Multilayer co-extrusion transfusion double-chamber bag |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103445961A (en) * | 2013-08-16 | 2013-12-18 | 华仁药业股份有限公司 | Liquid medicine bag for PD (Peritoneal Dialysis) |
| CN103800198A (en) * | 2014-02-24 | 2014-05-21 | 湖南科伦制药有限公司 | Powder-liquid double-cavity infusion bag and packaging method thereof |
| CN104837465A (en) * | 2012-12-28 | 2015-08-12 | 味之素株式会社 | Multi-chamber vessel |
| CN105167995A (en) * | 2015-08-14 | 2015-12-23 | 石家庄四药有限公司 | Sodium bicarbonate injection double-layer aseptic vertical bag package system and preparation method thereof |
| CN110220658A (en) * | 2019-05-23 | 2019-09-10 | 北京锐业制药有限公司 | A kind of high-frequency discharge leakage detection apparatus |
| CN111634065A (en) * | 2020-07-02 | 2020-09-08 | 山东新华医疗器械股份有限公司 | Multi-chamber soft bag and bag making method and equipment |
| CN112715200A (en) * | 2020-10-15 | 2021-04-30 | 芜湖职业技术学院 | Landscape plant infusion set |
| CN114018647A (en) * | 2021-11-02 | 2022-02-08 | 湖南醇健制药科技有限公司 | Sampling equipment and method for testing compatibility of medicine and infusion set |
-
2011
- 2011-08-30 CN CN2011203224468U patent/CN202236306U/en not_active Expired - Lifetime
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104837465B (en) * | 2012-12-28 | 2018-03-27 | Ea制药株式会社 | Multichamber vessel |
| CN104837465A (en) * | 2012-12-28 | 2015-08-12 | 味之素株式会社 | Multi-chamber vessel |
| CN103445961B (en) * | 2013-08-16 | 2015-09-30 | 华仁药业股份有限公司 | Peritoneal dialysis medicinal fluid bag |
| CN103445961A (en) * | 2013-08-16 | 2013-12-18 | 华仁药业股份有限公司 | Liquid medicine bag for PD (Peritoneal Dialysis) |
| CN103800198A (en) * | 2014-02-24 | 2014-05-21 | 湖南科伦制药有限公司 | Powder-liquid double-cavity infusion bag and packaging method thereof |
| CN105167995B (en) * | 2015-08-14 | 2018-12-25 | 石家庄四药有限公司 | A kind of sodium bicarbonate injection double-layer sterile butt-ended bag packaging system and preparation method |
| CN105167995A (en) * | 2015-08-14 | 2015-12-23 | 石家庄四药有限公司 | Sodium bicarbonate injection double-layer aseptic vertical bag package system and preparation method thereof |
| CN110220658A (en) * | 2019-05-23 | 2019-09-10 | 北京锐业制药有限公司 | A kind of high-frequency discharge leakage detection apparatus |
| CN110220658B (en) * | 2019-05-23 | 2024-03-12 | 北京锐业制药有限公司 | High-frequency discharge leakage detection device |
| CN111634065A (en) * | 2020-07-02 | 2020-09-08 | 山东新华医疗器械股份有限公司 | Multi-chamber soft bag and bag making method and equipment |
| CN112715200A (en) * | 2020-10-15 | 2021-04-30 | 芜湖职业技术学院 | Landscape plant infusion set |
| CN112715200B (en) * | 2020-10-15 | 2023-06-02 | 芜湖职业技术学院 | Garden plant transfusion device |
| CN114018647A (en) * | 2021-11-02 | 2022-02-08 | 湖南醇健制药科技有限公司 | Sampling equipment and method for testing compatibility of medicine and infusion set |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20120530 |