KR101811441B1

KR101811441B1 - 해수온 상승에 대응하는 말레이해파리 유전자 및 이를 이용한 말레이해파리의 생리 또는 대사 변화 예측방법

Info

Publication number: KR101811441B1
Application number: KR1020170096915A
Authority: KR
Inventors: 염승식; 이나영; 이나윤; 조예진
Original assignee: 한국해양과학기술원
Priority date: 2017-07-31
Filing date: 2017-07-31
Publication date: 2017-12-22
Also published as: DE102018001796B4; DE102018001796A1

Abstract

본 발명은 해수온 상승에 대응하는 말레이해파리(Sanderia malayensis)의 유전자 및 이를 이용한 말레이해파리의 생리 또는 대사 변화 예측방법에 관한 것으로, 구체적으로 말레이해파리 유전자를 활용한 마이크로어레이 분석을 통해, 25℃의 해수 노출 실험군에서는 50종의 유전자; 26℃의 해수 노출 실험군에서는 30종의 유전자; 27℃의 해수 노출 실험군에서는 26종의 유전자; 28℃의 해수 노출 실험군에서는 59종의 유전자가 2배 이상 발현이 변화되는 것을 확인하였고, 여기서 중복되는 유전자들을 제외한 총 112종의 유전자들이 상승된 수온에 대한 노출 스트레스에 의해 발현량이 변화되는 것을 확인함으로써, 이들 유전자들은 상승된 해수온에의 노출 여부를 확인할 수 있는 바이오마커로 유용하게 활용될 수 있으며, 해파리의 생리 또는 대사 변화, 즉 해파리의 대량 발생 예측에 유용하게 활용될 수 있다.

Description

해수온 상승에 대응하는 말레이해파리 유전자 및 이를 이용한 말레이해파리의 생리 또는 대사 변화 예측방법{RISING SEAWATER TEMPERATURE RESPONSIVE GENES IN SANDERIA MALAYENSIS AND PREDICTION METHOD FOR PHYSIOLOGICAL OR METABOLOGICAL CHANGING OF SANDERIA MALAYENSIS}

본 발명은 해수온 상승에 대응하는 말레이해파리(Sanderia malayensis)의 유전자 및 이를 이용한 말레이해파리의 생리 또는 대사 변화 예측방법에 관한 것이다.

기후 변화는 다양한 시간과 공간 속에서 변화하고 있는 지구의 기후 변화를 총칭하여 가리키는 것으로, 현재의 기후계가 자연적 요인 및 인위적 요인에 의하여 점차 변화하는 것을 의미한다. 자연적 요인으로는 대기, 해양, 육지 또는 설빙 등의 생물권 자신의 내적 요인 외에, 화산 분화에 의한 성층권의 에어로졸(부유 미립자) 증가, 태양 활동의 변화 또는 태양과 지구의 천문학적 상대위치 관계 등의 외적 요인이 있다. 인위적 요인으로는 화석연료 과다 사용에 따른 이산화탄소 등 대기 조성의 변화, 토지 피복의 변화, 삼림파괴 등이 있다. 특히, 최근에는 인간의 활동으로 발생하는 온실 가스의 대기 중 농도 증가로 인한 지구 온난화가 큰 문제로 가속화되고 있으며, 이로 인한 범지구적인 기후의 변화는 현재 해수온의 상승 및 해수의 산성화를 유발하고 있다. 이러한 해수의 변화는 해양에 살고 있는 생물들의 대사 및 생리를 변화시키며, 최종적으로는 해양 생태계를 교란시킨다. 이러한 환경 변화의 스트레스에 대응하기 위해 초기에 생물들은 특정 유전자의 발현량을 조절하여 생리 또는 대사를 변화시킴으로써 환경의 변화에 능동적으로 대처한다.

따라서, 상기와 같은 외부의 환경 변화에 의해 발현량이 변화되는 유전자들을 발굴하여 생체지표로 이용한다면 특정 지역의 환경 변화 또는 환경 변화의 정도 등에 관한 정보뿐만 아니라, 이러한 환경 변화가 생명 현상에 미치는 영향 및 해당 생물의 건강 진단에 관한 정보를 얻을 수 있다. 이러한 기법은 미세한 환경 변화도 감지가 가능하고, 조기 진단의 가치를 가지며, 유전자 기능에 대한 고찰을 통해 미래 예측 효과도 가질 수 있다. 기후변화에 따른 생태계의 교란에 의한 위험성이 제기되고 있는 현 상황에서, 생명 현상의 기본인 유전자와 핵산 물질의 분석을 통해 환경변화의 영향과 생태계의 파급 효과를 정확히 진단하는 첨단기술 개발의 필요성이 요구된다.

한편, 최근 세계 각지에서 해파리의 개체군이 점점 증가하고 있다. 해파리의 대량 발생은 어업, 해양레저, 발전산업 등에 큰 경제적 손실을 초래하고 있다. 해파리는 주로 동물 플랑크톤과 작은 어류를 포식하기 때문에 해파리의 증가로 인한 동물 플랑크톤의 감소는 식물 플랑크톤의 증식을 유발할 수 있다. 해파리의 대량 발생은 전 지구적으로 일어나는 기후 변화의 영향일 것으로 추정되고 있으며, 여기에는 수온 상승 또는 해양 산성화 등이 크게 영향을 미치고 있는 것으로 예측된다(Attrill et al. 2007).

해파리는 자포동물 문(Cnidaria), 해파리 강(Scyphozoa)에 속하는 동물이다. 이들은 수정란, 플라눌라(planula) 유생, 폴립(polyp), 스트로빌라(strobila) 및 에피라(ephyra)의 단계를 거쳐 성체로 발생하는 매우 독특한 생활사를 갖는다(도 1). 해파리들의 급격한 개체수의 증가는 폴립 또는 스트로빌라 시기에 일어난다. 따라서, 해파리의 대량 발생 원인을 파악하기 위해서는 상기 폴립의 시기를 대상으로 한 연구가 필요하다.

이에, 본 발명자들은 말레이해파리의 폴립을 대상으로 해수온 변화에 대응할 수 있는 생체 지표를 발굴하기 위해 연구하던 중, 해파리의 생리 또는 대사 변화를 예측할 수 있는 다양한 특이 유전자 바이오 마커 후보들을 발굴함으로써, 본 발명을 완성하였다.

Attrill, M. J., Wright, J., and Edwards, M., 2007, Limnol. Oceanogr., 52(1): 480-485.

본 발명의 목적은 해수온 상승에 대응하여 발현량이 변화된 말레이해파리 유전자 및 이를 이용한 해파리류의 생리 또는 대사 변화 예측방법을 제공하는 것이다.

상기 목적을 달성하기 위하여, 본 발명은 서열번호 1 내지 112로 기재되는 모든 유전자 각각의 핵산 서열을 구성하는 올리고뉴클레오티드 또는 그의 상보가닥 분자가 집적된, 말레이해파리의 고온 스트레스에 대한 노출 여부 검출용 마이크로어레이(microarray) 칩을 제공한다.

또한, 본 발명은 1) 고온 스트레스에 노출된 실험군의 말레이해파리와, 정상 대조군의 말레이해파리에서 각각 RNA를 분리하는 단계; 2) 단계 1)의 실험군 및 대조군의 RNA로부터 cDNA를 합성하면서 실험군과 대조군을 각기 다른 형광물질로 표지하는 단계; 3) 단계 2)의 각기 다른 형광물질로 표지된 cDNA를 제 1항의 마이크로어레이 칩과 혼성화시키는 단계; 4) 혼성화된 마이크로어레이 칩을 분석하는 단계; 및 5) 분석한 데이터에서 제 1항의 마이크로어레이 칩에 집적된 유전자 발현 정도를 대조군과 비교하여 확인하는 단계를 포함하는, 말레이해파리의 고온 스트레스에 대한 노출 여부 검출 방법을 제공한다.

또한, 본 발명은 1) 고온 스트레스에 노출된 실험군의 말레이해파리와, 정상 대조군의 말레이해파리에서 각각 RNA를 분리하는 단계; 2) 단계 1)의 RNA를, 서열번호 1 내지 112로 기재되는 모든 유전자 각각에 상보적이고 이를 증폭할 수 있는 프라이머 쌍을 사용하여 정량 실시간 RT-PCR(Quantitative real-time reverse transcript polymerase chain reaction, qRT-PCR)을 수행하는 단계; 및 3) 단계 2)의 유전자 산물을 대조군과 비교하여 발현 정도를 확인하는 단계를 포함하는, 말레이해파리의 고온 스트레스에 대한 노출 여부 검출 방법을 제공한다.

또한, 본 발명은 상기의 마이크로어레이 칩을 포함하는 말레이해파리의 고온 스트레스 노출 여부 검출용 키트를 제공한다.

아울러, 본 발명은 서열번호 1 내지 112로 기재되는 모든 유전자 각각에 상보적이고 이를 증폭할 수 있는 프라이머 쌍을 모두 포함하는 말레이해파리의 고온 스트레스 노출 여부 검출용 키트를 제공한다.

본 발명은 말레이해파리 유전자를 활용한 마이크로어레이 분석을 통해, 25℃의 해수 노출 실험군에서는 50종의 유전자; 26℃의 해수 노출 실험군에서는 30종의 유전자; 27℃의 해수 노출 실험군에서는 26종의 유전자; 28℃의 해수 노출 실험군에서는 59종의 유전자가 2배 이상 발현이 변화되는 것을 확인하였고, 여기서 중복되는 유전자들을 제외한 총 112종의 유전자들이 상승된 수온에 대한 노출 스트레스에 의해 발현량이 변화되는 것을 확인함으로써, 이들 유전자들은 상승된 해수온에의 노출 여부를 확인할 수 있는 바이오마커로 유용하게 활용될 수 있으며, 해파리의 생리 또는 대사 변화, 즉 해파리의 대량 발생 예측에 유용하게 활용될 수 있다.

도 1은 말레이해파리의 생활사를 나타낸 도이다.
도 2는 말레이해파리 폴립을 25, 26, 27 또는 28℃의 고온 해수에 노출시킨 실험을 촬영한 사진이다.
도 3은 말레이해파리의 유전자 정보 16,652종을 탑재한 SMA Expressed Gene 마이크로어레이를 나타낸 도이다.
도 4는 고온 해수 스트레스에 노출된 말레이해파리의 유전자를 이용하여 마이크로어레이 실험을 수행한 뒤, 온도(℃)별로 차등 발현된 유전자를 프로파일링하여 나타낸 결과이다.

이하, 본 발명을 상세히 설명한다.

본 발명은 상승된 수온 노출에 의한 스트레스에 대응하여 발현이 변화하는 말레이해파리 유래의 유전자를 발굴하였으며, 상기 해수 온도 변화에 대하여 발현량이 변화하는 말레이해파리 유래 유전자를 집적한 본 발명에 따른 마이크로어레이 칩은 고온 해수 노출의 여부 검출 및 해파리류의 생리 또는 대사변화를 예측하는데 이용할 수 있다.

본 발명은 서열번호 1 내지 112로 기재되는 모든 유전자 각각의 핵산 서열을 구성하는 올리고뉴클레오티드 또는 그의 상보가닥 분자가 집적된, 말레이해파리의 고온 스트레스에 대한 노출 여부 검출용 마이크로어레이 칩을 제공한다.

상기 유전자는 말레이해파리로부터 유래된 것일 수 있다.

상기 말레이해파리 마이크로어레이 칩은 당업자에게 알려진 방법으로 제작될 수 있다. 구체적으로, 상기 탐색된 유전자를 프로브로 이용하여 마이크로어레이 칩의 기판상에 고정화시킬 수 있다. 이때, 파이조일렉트릭(piezoelectric) 방식을 이용한 마이크로피펫팅(micropipetting)법 또는 핀(pin) 형태의 스폿터(spotter)를 이용한 방법 등이 사용될 수 있다. 상기 마이크로어레이 칩의 기판에는 아미노-실란(amino-silane), 폴리-L-라이신(poly-Llysine) 및 알데히드(aldehyde)로 이루어진 군에서 선택되는 하나 이상의 활성기가 코팅될 수 있다. 또한, 상기 기판은 슬라이드 글라스, 플라스틱, 금속, 실리콘, 나일론 막, 및 니트로셀룰로스 막으로 이루어진 군에서 선택되는 것으로 제조된 것일 수 있다.

상기 단계 2)의 형광물질은 Cy3, Cy5, FITC(poly L-lysine-fluorescein isothiocyanate), RITC(rhodamine-B-isothiocyanate) 및 로다민(rhodamine)으로 이루어진 군으로부터 선택되는 것일 수 있다.

또한, 본 발명은 상기 마이크로어레이 칩을 포함하는 말레이해파리의 고온 스트레스 노출 여부 검출용 키트를 제공한다.

상기 키트는 스트렙타비딘-알칼리 탈인화효소 접합물질(strepavidin -like phosphatease conjugate), 화학형광물질(chemiflurorensce) 및 화학발광물질(chemiluminescent)로 이루어진 형광물질군으로부터 선택되는 어느 하나 이상을 추가적으로 포함할 수 있다.

또한, 상기 키트는 혼성화에 사용되는 완충용액, RNA로부터 cDNA(complementary DNA)를 합성하기 위한 역전사효소, dNTPs(deoxynucleotide triphosphates) 및 rNTPs(ribonucleotide triPhosphates, 사전 혼합형 또는 분리 공급형), 표식시약, 및 세척 완충용액으로 이루어진 반응 시약군으로부터 선택되는 어느 하나 이상을 추가적으로 포함할 수 있다.

본 발명의 구체적인 실시예에서, 본 발명자들은 상승된 수온의 해수에 노출시 변화하는 말레이해파리 유래의 유전자를 발굴하기 위하여, 말레이해파리의 폴립을 배양하여 상승된 수온의 해수(25, 26, 27 또는 28℃)에서 30일 동안 배양하여 고온의 해수에 노출시킨 후(도 2 참조), 이로부터 RNA를 분리하고, cDNA를 합성한 뒤, Cy3 및 Cy5로 표지하여 말레이해파리 유전자의 어레이를 활용한, 마이크로어레이 분석을 실시하였다(도 3 및 도 4 참조). 그 결과, 일반 배양조건인 24℃의 해수에서 배양된 말레이해파리 대조군과 비교하여 25℃의 해수 노출 실험군에서는 50종의 유전자(표 1 참조); 26℃의 해수 노출 실험군에서는 30종의 유전자(표 2 참조); 27℃의 해수 노출 실험군에서는 26종의 유전자(표 3 참조); 28℃의 해수 노출 실험군에서는 59종의 유전자(표 4 참조)들이 2배 이상 발현이 변화되는 것을 확인하였고, 중복되는 유전자들을 제외한 총 112종의 유전자들이 고온 해수 노출에 의해 발현량이 변화되는 것을 확인하였다(표 5 및 도 4 참조).

따라서, 상기 유전자들은 상승된 해수온에 말레이해파리가 노출되었는지 여부를 확인할 수 있는 바이오마커로 유용하게 활용될 수 있으며, 해파리의 생리 또는 대사 변화, 즉 해파리의 대량 발생 예측에도 유용하게 활용될 수 있다.

이하, 본 발명을 실시예에 의해 상세히 설명한다.

단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 하기 실시예에 의해서 한정되는 것은 아니다.

< 실시예 1> 말레이해파리의 배양 및 고온 해수 조건 노출

<1-1> 말레이해파리의 배양

말레이해파리의 폴립을 제주 아쿠아 플라넷에서 분양받아 세 종류의 필터(100, 10 및 1 μm, Spun Polypropylene filter cartilage, Heathy)로 여과된 자연 해수에서 배양하였다. 수온은 배양실 실내 기온인 24℃로 고정하였으며, 하루 한번 아르테미아(Artemia) 유생을 먹이로 공급하였다.

<1-2> 고온 해수 조건 노출 및 무성생식의 관찰

일반 배양조건인 24℃를 대조군으로 하여 4가지의 수온 조건인 25, 26, 27 또는 28℃에서 최초 말레이해파리의 폴립을 10 개체씩 30일 동안 배양하였다(도 2). 배양 중 폴립의 무성생식에 의해 개체수가 증가되었는데, 24℃ 대조군에서는 52개체, 25℃ 노출 실험군에서는 86개체, 26℃ 노출 실험군에서는 85개체, 27℃ 노출 실험군에서는 70개체, 28℃ 노출 실험군에서는 101개체가 확인되었다. 에피라(ephyra)는 24℃ 대조군에서만 실험시작 15일 후부터 나타났으며, 다른 실험군에서는 발생되지 않았다.

< 실시예 2> 말레이해파리 마이크로어레이의 제작

말레이해파리 마이크로어레이의 제작을 위한 유전자 서열정보는 말레이해파리의 폴립, 에피라 및 성체 전사체의 분석결과로 얻어진 유전자 서열정보를 활용하였다. 총 18,732종의 유전자를 대상으로 총 16,652종의 60-mer의 올리고 프로브(oligo-probe)를 디자인하고, 이를 합성하여 슬라이드 글라스 위에 탑재함으로써, SMA Expressed Gene 마이크로어레이를 제작하였다(도 3).

< 실시예 3> 고온 해수 노출에 의한 유전자 발현량 변화 측정

<3-1> RNA의 분리

상기 실시예 <1-2>에서 수득한 고온 해수 노출 조건(25, 26, 27 또는 28℃)에서 배양한 실험군 및 일반 배양조건인 24℃에서 배양한 대조군의 말레이해파리 폴립으로부터 RNA를 추출하였다. 추출은 연산호류의 RNA추출을 위해 개발된 방법을 따랐다. 즉, 말레이해파리 폴립을 막자사발에서 액체질소를 이용하여 분말로 만들고, 700 ㎕의 용해(lysis) 용액[35 mM EDTA, 0.7 M LiCl, 7% SDS, 200 mM Tris-Cl(pH 9.0)]을 첨가하여 균질화시켰다. 상기 균질물에 동량의 페놀 용액을 첨가하고 잘 섞은 후, 10분간 원심분리하여, 상층액을 취해 새 튜브로 옮기고 총 용량의 1/3에 해당하는 8 M 염화리튬(LiCl)을 첨가하였다. 이를 잘 섞은 후에 4℃에서 2시간 이상 방치하였다. 상기 혼합물을 약 30분간 원심분리하여 상등액을 제거하고 침전물을 취하여 300 ㎕의 침전수에 녹였다. 상기 현탁액의 1/10 용량의 3 M 아세트산나트륨(pH 5.2)과 동량의 이소프로판올(isopropanol)을 첨가하고 이를 약 30분간 원심분리하여 상등액을 제거하고 침전물을 취하였다. 상기 침전물에 50 ㎕의 에탄올 용액(70%)을 넣어 5분간 원심분리한 뒤, 에탄올 용액을 제거하고 침전된 RNA를 건조시켰다. 건조 후, 상기 RNA를 적당량의 디에틸피로카보네이트(diethylpyrocarbonate, DEPC)로 처리한 멸균수에 용해시켰다.

<3-2> Cy2 및 Cy5 표지

정제된 실험군 및 대조군의 전체 RNA는 Agilent's Low RNA Input Linear Amplification Kit Plus(Agilent Technologies, 미국)를 사용하여 제조사의 프로토콜을 따라 다음과 같이 Cy3 및 Cy5로 표지하였다.

구체적으로, 1 ㎍의 RNA를 dT-프로모터 프라이머(dT-promoter primer)와 MMLV-역전사효소(MMLV-Reverse transcriptase)와 혼합하여 40℃에서 2시간 동안 역전사 반응을 수행하였다. 다음으로, 여기에 T7 중합효소(T7 polymerase)를 첨가하여 40℃에서 2시간 동안 선형 증폭(linear amplification)을 수행하였다. 이와 같은 증폭과정을 통해 실험군 및 대조군의 시료를 각각 Cy3-CTP와 Cy5-CTP로 표지하였다.

<3-3> 혼성화 (Hybridization) 및 스캐닝(scanning)

형광물질이 표지된 cRNA 시료를 Qiagen PCR 정제 키트를 사용하여 정제하고, 증류수로 용출하였다. 정제된 형광표지-cRNA 시료를 혼성화 완충액(hybridization buffer)(3×SSC, 0.3% SDS, 50% 포름아미드(formamide), 20 ㎍ Cot-1 DNA, 20 ㎍ 효모균(yeast) tRNA)에 첨가한 후, microcon YM-30으로 농축하여 혼성화 혼합물을 만들었다. 혼성화 혼합물을 95℃에서 3분 동안 가열하여 변성시키고 12,000×g에서 30초간 원심분리하며 온도를 낮추었다. 상기 실시예 2에서 제조된 말레이해파리 올리고-마이크로어레이에 커버슬립(coverslip)을 덮고, 변성시킨 혼성화 혼합물을 파이펫팅(pipetting)하였다. 그 후, 상기 마이크로어레이를 GT-Hyb 챔버(Chamber)에 넣고 65℃에서 16시간 동안 반응시켜 혼성화 시켰고, 혼성화가 끝난 후, 챔버에서 마이크로어레이를 꺼내어 세척하였다. 세척된 마이크로어레이를 회전하여 건조시킨 후 스캐닝할 때까지 암실에서 보관하였다. 실험이 완료된 말레이해파리 마이크로어레이를 Axon GenePix 4000B 스캐너(Axon Instrument, 미국)를 사용하여 스캔하였다. GenePix Pro 6.0 프로그램을 이용하여, 스캔 이미지로부터 각 점을 그리딩(gridding) 파일을 이용하여 그리딩하고, 정량화하여 각 점의 Cy5/Cy3 강도 및 비율 등의 분석값이 포함된 GPR 파일을 얻었다.

<3-4> 마이크로어레이 자료 분석

GenePix Pro 프로그램으로 얻어진 GPR 파일로부터, 분석 프로그램인 GeneSpring 7.3.1(Agilent Technologies, 미국)을 이용하여 다음과 같이 분석을 수행하였다. 표준화(Normalization)는 LOWESS(locally weighted regression scatterplot smoothing)를 이용하여 수행하였고, 신뢰할 수 있는 유전자(Reliable gene)는 중앙값의 합이 배경(background) 보다 낮거나, 각 화소(pixel) 값의 표준편차가 유의하지 않은 점을 플래그 아웃(flag-out)함으로써 유의한 유전자를 얻었다. 유의한 유전자(Significant genes)로서 평준화된 비율(normalized ratio) 값이 1.5배 이상 차이를 보이는 점을 선별하였다.

그 결과, 상승된 수온의 해수(25, 26, 27 또는 28℃)에서 배양된 실험군에서 유전자 발현량이 2.0 배 이상 차등 발현한 유전자들을 선별화 및 그룹화하였다(도 4), 구체적으로, 25℃의 해수 노출 실험군에서는 50종(증가 14종, 감소 36종, 표 1), 26℃의 해수 노출 실험군에서는 30종(증가 6종, 감소 24종, 표 2), 27℃의 해수 노출 실험군에서는 26종(증가 7종, 감소 19종, 표 3), 28℃의 해수 노출 실험군에서는 59종(증가 30종, 감소 29종, 표 4)의 유전자들의 발현량이 변화되었다. 이들 중 중복되는 유전자들을 제외하면, 표 5에 나타난 바와 같이, 총 112종의 유전자들이 고온 해수 노출에 의해 발현량이 변화되는 것을 확인하였다.

따라서, 이들 유전자들은 해수온 상승에 의한 말레이해파리류의 생리 및 대사변화 예측을 위한 바이오마커로 활용 가능할 것으로 생각되며, 또한 해양환경변화에 따른 해파리 대량 발생의 이해에도 활용 가능할 것으로 예측된다.

말레이해파리 폴립 25℃ 해수 노출 실험군의 차등발현 유전자 목록 및 발현량 변화(총 50종; +: 발현 증가, -: 발현 감소)

유전자	발현변화 (배)
mab-21 like 2	4.72
cytidine deaminase-like	3.52
collagen-like protein 2	3.02
CREB binding protein	2.98
cyclic GMP-AMP synthase	2.94
serine/threonine-protein kinase 32B-like	2.57
transient receptor potential cation channel subfamily M member 2	2.54
protocadherin Fat 4-like	2.46
spore coat protein SP65-like	2.35
retinoic acid receptor responder (tazarotene induced) 3	2.30
nuclear factor, erythroid derived 2,-like 1	2.23
pyroglutamylated RFamide peptide receptor	2.15
protein Wnt-4-like	2.12
cholinergic receptor, nicotinic delta	2.10
ribosomal protein S13	-2.00
60S ribosomal protein L18-like	-2.01
cell cycle associated protein 1	-2.02
heat shock protein 90kDa alpha family class A member 1	-2.03
cell wall protein PRY3-like	-2.04
leukotriene-B4 omega-hydroxylase 3-like	-2.06
carnitine O-palmitoyltransferase 1, liver isoform-like	-2.07
chymotrypsinogen B-like	-2.10
ATP-dependent RNA helicase eIF4A	-2.13
AAEL015006-PA	-2.16
endoglucanase 6	-2.17
collagen alpha-1(I) chain-like	-2.18
zonadhesin-like	-2.18
nucleolin 2-like	-2.19
transcription factor 15-like	-2.23
balbiani ring protein 3-like	-2.23
gremlin 1, DAN family BMP antagonist	-2.24
40S ribosomal protein S21-like	-2.25
calmodulin 1	-2.31
heat shock protein 83	-2.37
soluble guanylate cyclase 88E	-2.37
nucleolar GTP-binding protein 1	-2.44
RNA-binding motif, single-stranded-interacting protein 1-like	-2.45
threonine--tRNA ligase, cytoplasmic	-2.46
trypsin-3-like	-2.47
60S ribosomal protein l22-like 1	-2.48
axoneme-associated protein mst101(2)-like	-2.61
ganglioside GM2 activator	-3.08
serine protease 56-like	-3.29
muscle-specific protein 20-like	-3.41
cubilin (intrinsic factor-cobalamin receptor)	-3.95
protein SpAN-like	-6.34
heterogeneous nuclear ribonucleoprotein L-like	-6.39
spermidine synthase-like	-8.76
tropomyosin-1-like	-12.03
neo-calmodulin-like	-16.58

말레이해파리 폴립 26℃ 해수 노출 실험군의 차등발현 유전자 목록 및 발현량 변화(총 30종; +: 발현 증가, -: 발현 감소)

유전자	발현변화 (배)
mab-21 like 2	3.91
protein Wnt-4-like	2.35
metalloproteinase	2.28
collagen-like protein 2	2.27
prolactin releasing hormone receptor	2.19
trehalase	2.08
heparan sulfate proteoglycan 2	-2.01
heterogeneous nuclear ribonucleoprotein K-like	-2.04
phospholipase B1, membrane-associated-like	-2.05
Titin homolog	-2.11
FOS like antigen 2	-2.17
cell wall protein PRY3-like	-2.28
leukotriene-B4 omega-hydroxylase 3-like	-2.32
hornerin-like	-2.36
GD16675 gene product from transcript GD16675-RA	-2.37
low density lipoprotein receptor-related protein 2	-2.59
RNA-binding motif, single-stranded-interacting protein 1-like	-2.61
aquaporin 4	-3.45
tropomyosin-1-like	-3.47
endoglucanase 6	-3.84
serine protease 56-like	-4.12
muscle-specific protein 20-like	-4.25
gremlin 1, DAN family BMP antagonist	-4.30
protein argonaute-2	-5.37
neo-calmodulin-like	-7.38
trypsin-3-like	-7.53
cubilin (intrinsic factor-cobalamin receptor)	-8.78
spermidine synthase-like	-8.82
heterogeneous nuclear ribonucleoprotein L-like	-9.95
protein SpAN-like	-18.77

말레이해파리 폴립 27℃ 해수 노출 실험군의 차등발현 유전자 목록 및 발현량 변화(총 26종; +: 발현 증가, -: 발현 감소)

유전자	발현변화 (배)
transient receptor potential cation channel subfamily M member 2	5.32
nicotinate phosphoribosyltransferase	2.51
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2	2.34
snurportin 1	2.30
DAN domain BMP antagonist family member 5	2.29
GJ18296 gene product from transcript GJ18296-RA	2.24
Tight junction protein ZO-3	2.14
protein kinase, X-linked	-2.39
RNA-binding motif, single-stranded-interacting protein 1-like	-2.55
transforming growth factor-beta-induced protein ig-h3	-2.80
cell wall protein PRY3-like	-2.92
endoglucanase 6	-3.08
alkylglycerol monooxygenase-like	-3.29
aquaporin 4	-3.55
tropomyosin-1-like	-3.58
serine protease 56-like	-3.90
muscle-specific protein 20-like	-4.05
mucin-4-like	-4.06
gremlin 1, DAN family BMP antagonist	-4.16
ganglioside GM2 activator	-5.77
spermidine synthase-like	-6.50
trypsin-3-like	-7.10
spermidine synthase-like	-7.15
cubilin (intrinsic factor-cobalamin receptor)	-7.64
neo-calmodulin-like	-8.38
heterogeneous nuclear ribonucleoprotein L-like	-13.51

말레이해파리 폴립 28℃ 해수 노출 실험군의 차등발현 유전자 목록 및 발현량 변화(총 59종; +: 발현 증가, -: 발현 감소)

유전자	발현변화 (배)
CREB binding protein	4.57
mab-21 like 2	4.34
ETS domain-containing protein Elk-1	3.58
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	3.42
UPF0705 protein C11orf49 homolog	3.38
proline rich 11	3.22
roundabout	3.20
netrin receptor UNC5C-like	3.10
zinc finger CCCH-type containing 12B	3.01
transient receptor potential cation channel, subfamily M, member 3	2.97
Tight junction protein ZO-3	2.92
cyclic GMP-AMP synthase	2.87
protocadherin Fat 4-like	2.85
trehalase	2.82
poly (ADP-ribose) polymerase family, member 12	2.80
radial spoke head 10 homolog B	2.69
protein lifeguard 1	2.69
axin interactor, dorsalization associated	2.62
chitobiase, di-N-acetyl-	2.60
dual specificity phosphatase 12	2.33
ATP-dependent RNA helicase DEAH11, chloroplastic	2.32
SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	2.20
transcription factor ETV6-like	2.14
techylectin-5B-like	2.13
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	2.10
leptin receptor gene-related protein-like	2.09
tetratricopeptide repeat domain 34	2.08
retinoic acid receptor responder (tazarotene induced) 3	2.05
phospholipid scramblase 1-like	2.03
protein tyrosine phosphatase, receptor type, D	2.00
dual specificity protein kinase Ttk-like	-2.08
calmodulin 1	-2.17
zonadhesin-like	-2.21
kinesin-like protein KIF23	-2.27
RNA-binding motif, single-stranded-interacting protein 1-like	-2.46
TPX2, microtubule-associated	-2.51
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	-2.56
low density lipoprotein receptor-related protein 2	-2.57
retinitis pigmentosa 1-like 1 protein	-2.65
transforming growth factor-beta-induced protein ig-h3	-2.72
deiodinase, iodothyronine, type I	-2.75
axoneme-associated protein mst101(2)-like	-2.76
collagen alpha-1(I) chain-like	-2.78
stromelysin-3-like	-3.29
tropomyosin-1-like	-3.48
aquaporin 4	-3.53
mucin-4-like	-3.56
transcription factor 15-like	-3.57
endoglucanase 6	-3.57
muscle-specific protein 20-like	-3.95
serine protease 56-like	-4.33
cell wall protein PRY3-like	-4.63
gremlin 1, DAN family BMP antagonist	-5.09
ganglioside GM2 activator	-5.46
trypsin-3-like	-6.07
hornerin-like	-6.11
spermidine synthase-like	-8.72
neo-calmodulin-like	-9.67
cubilin (intrinsic factor-cobalamin receptor)	-10.16

말레이해파리 폴립의 고온 해수 노출에 의한 발현량 변화 공통 유전자 목록(총 112종)

서열번호	유전자
1	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
2	40S ribosomal protein S21-like
3	60S ribosomal protein L18-like
4	60S ribosomal protein l22-like 1
5	AAEL015006-PA
6	alkylglycerol monooxygenase-like
7	aquaporin 4
8	ATP-dependent RNA helicase DEAH11, chloroplastic
9	ATP-dependent RNA helicase eIF4A
10	axin interactor, dorsalization associated
11	axoneme-associated protein mst101(2)-like
12	balbiani ring protein 3-like
13	calmodulin 1
14	carnitine O-palmitoyltransferase 1, liver isoform-like
15	cell cycle associated protein 1
16	cell wall protein PRY3-like-1
17	cell wall protein PRY3-like-2
18	cell wall protein PRY3-like-3
19	chitobiase, di-N-acetyl-
20	cholinergic receptor, nicotinic delta
21	chymotrypsinogen B-like
22	collagen alpha-1(I) chain-like-1
23	collagen alpha-1(I) chain-like-2
24	collagen-like protein 2
25	CREB binding protein
26	cubilin (intrinsic factor-cobalamin receptor)
27	cyclic GMP-AMP synthase
28	cytidine deaminase-like
29	DAN domain BMP antagonist family member 5
30	deiodinase, iodothyronine, type I
31	dual specificity phosphatase 12
32	dual specificity protein kinase Ttk-like
33	endoglucanase 6
34	ETS domain-containing protein Elk-1
35	FOS like antigen 2
36	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
37	ganglioside GM2 activator
38	GD16675 gene product from transcript GD16675-RA
39	GJ18296 gene product from transcript GJ18296-RA
40	gremlin 1, DAN family BMP antagonist
41	heat shock protein 83
42	heat shock protein 90kDa alpha family class A member 1
43	heparan sulfate proteoglycan 2
44	heterogeneous nuclear ribonucleoprotein K-like
45	heterogeneous nuclear ribonucleoprotein L-like
46	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
47	hornerin-like
48	kinesin-like protein KIF23
49	leptin receptor gene-related protein-like
50	leukotriene-B4 omega-hydroxylase 3-like-1
51	leukotriene-B4 omega-hydroxylase 3-like-2
52	low density lipoprotein receptor-related protein 2
53	mab-21 like 2
54	metalloproteinase
55	mucin-4-like
56	muscle-specific protein 20-like-1
57	muscle-specific protein 20-like-2
58	neo-calmodulin-like
59	netrin receptor UNC5C-like
60	nicotinate phosphoribosyltransferase
61	nuclear factor, erythroid derived 2,-like 1
62	nucleolar GTP-binding protein 1
63	nucleolin 2-like
64	phospholipase B1, membrane-associated-like
65	phospholipid scramblase 1-like
66	poly (ADP-ribose) polymerase family, member 12
67	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
68	prolactin releasing hormone receptor
69	proline rich 11
70	protein argonaute-2
71	protein kinase, X-linked
72	protein lifeguard 1
73	protein SpAN-like
74	protein tyrosine phosphatase, receptor type, D
75	protein Wnt-4-like
76	protocadherin Fat 4-like
77	pyroglutamylated RFamide peptide receptor
78	radial spoke head 10 homolog B
79	retinitis pigmentosa 1-like 1 protein
80	retinoic acid receptor responder (tazarotene induced) 3
81	ribosomal protein S13
82	RNA-binding motif, single-stranded-interacting protein 1-like-1
83	RNA-binding motif, single-stranded-interacting protein 1-like-2
84	roundabout
85	serine protease 56-like
86	serine/threonine-protein kinase 32B-like
87	snurportin 1
88	soluble guanylate cyclase 88E
89	spermidine synthase-like-1
90	spermidine synthase-like-2
91	spore coat protein SP65-like
92	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)
93	stromelysin-3-like
94	techylectin-5B-like
95	tetratricopeptide repeat domain 34
96	threonine--tRNA ligase, cytoplasmic
97	Tight junction protein ZO-3-1
98	Tight junction protein ZO-3-2
99	Titin homolog
100	TPX2, microtubule-associated
101	transcription factor 15-like
102	transcription factor ETV6-like
103	transforming growth factor-beta-induced protein ig-h3-1
104	transforming growth factor-beta-induced protein ig-h3-2
105	transient receptor potential cation channel subfamily M member 2
106	transient receptor potential cation channel, subfamily M, member 3
107	Trehalase
108	tropomyosin-1-like
109	trypsin-3-like
110	UPF0705 protein C11orf49 homolog
111	zinc finger CCCH-type containing 12B
112	zonadhesin-like

<110> Korea Ocean Research Development Institute <120> RISING SEAWATER TEMPERATURE RESPONSIVE GENES IN SANDERIA MALAYENSIS AND PREDICTION METHOD FOR PHYSIOLOGICAL OR METABOLOGICAL CHANGING OF SANDERIA MALAYENSIS <130> 2017P-06-022 <160> 112 <170> KoPatentIn 3.0 <210> 1 <211> 858 <212> DNA <213> Artificial Sequence <220> <223> 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 <400> 1 atgcggaaga taaaagagga aatagaacgg cggcaatcat tgggaaatga atctgttaaa 60 aggaagaata taatttcaca aagatacaaa catattcatc gtgatttatt gcaactcaag 120 agaagccatt tatctgaaca atttctggaa gtagtaagcc ttgcatctga caaggattgt 180 tcaactgaat cactcattca gaagttgcaa aaagagaatg ctccacattg ctatagcttc 240 caagtattta caaatgagtt ttgtgacaag ctcattgaag aaattgagag ttttgagaag 300 tctggattgc ctattggaaa gccaaataca atgaataatt atgggatagt actttctgag 360 cttggctaca aagaaggtct ttttgatcca ctagttgctg attacttgaa tccaattgcc 420 agtcgtttgt tcccagatga agtcggaaaa ggccttgatt cacatcgcac cttcattgtc 480 agttatgcca ttggcaaaga cactgatttg agttatcatt atgatgatgc cgaggtaaca 540 cttaatgttg ctcttggcaa ccaatttgaa ggcggagaac tctatcttag cggcatgaag 600 agtgaagtca attggagtga cgtttgttat aaatactgcc atcgcaaaac atgggggtta 660 atccatcgcg gacaacagat gcacggggcg atgccgatcg aagaaggaca acgctacaat 720 ctgataatct ggatgagggc atcatccgta cgaaaccaga tctgtcccat gtgtaatcgc 780 aaaccggatt tggtttcaac tgaggccgat ggtgcaggat tctcgatgga accattcgaa 840 ctttgctcga cattataa 858 <210> 2 <211> 405 <212> DNA <213> Artificial Sequence <220> <223> 40S ribosomal protein S21-like <400> 2 gtggtcagta tgtgcacatg cgcattgcat actcacttgt actatgaatc atgggaagtc 60 acgctgcatg ttctatttct tttcggccat cttaattttg tgaaaagacc gcacgtcttg 120 gttatcataa aactaattct cgtcatgcaa aacgaagcaa aagaaaacgt tgatctttac 180 cttcccagaa agtgctctgc aacaaacaat attatttctg cgaaagatca tgcctctgta 240 caaatcagca ttgctgaggt tgataatgag ggcagaatga ctggactctt taaaacttat 300 gccttctgtg gaaaaatcag aggacagggt gaagcagatg atgctcttgt aaacctctgc 360 ttacgtgatg gaattttgtc aaaaaacttc aacacatata attaa 405 <210> 3 <211> 567 <212> DNA <213> Artificial Sequence <220> <223> 60S ribosomal protein L18-like <400> 3 atgggtatcg acattgacca ccgcttcgaa aagaagaagc taagaaagga accagtatct 60 caagatgtct accttcgatt gctcgtaaag ctctaccgat ttcttgcacg aagaacaagt 120 tcgtctttca atgcagtcgt cttgaaaaga ctttttatga gcaagactag cagacctcca 180 gtctctcttg caagaattgt gaggagagta aagaagccag gcaatgaagg aaaaattgtt 240 gttactgtct caactgtaac tgatgacatt agaattcacg acattccaaa gttgaaggtc 300 tgtgctttaa gatttactga aggtgcacgt gcaagaatcc tcaaagctgg cggagaagtc 360 attacttttg atcaacttgc actcatgtcc ccaactggaa agaacacagt tttgatgcaa 420 ggtccacgaa atgcaagaga atcatgcaga cattttggcc cagccccagg agtgcctcac 480 agtactacca agccttttgt cagagctaaa ggaaggaaat ttgagagagc cagaggacga 540 cgcaagagtc gtggattcaa agtttaa 567 <210> 4 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> 60S ribosomal protein l22-like 1 <400> 4 atggcaccta aatcaaagaa gcaacagaag aagaagacag cgttgaagtt caccatcgac 60 tgcacgcatc cagtcgaaga tggaatcatg aaggttgatg acctggaaac tttcttgcaa 120 acaagaatta aagttgacaa taagaccaac aactttggag atcaagtttc tttggaaaga 180 ggaaagaaca agataacctt ggtttctgag agacctttct caaagagata tctcaaatat 240 ttgacgaaga agtatttgaa gaagaacaat cttcgtgatt ggctccgtgt tgtggcctca 300 aatcagactt cttatgaatt gagatacttc cagatcaaca atgaagatga agaagaagat 360 gaaggcgatg attaa 375 <210> 5 <211> 423 <212> DNA <213> Artificial Sequence <220> <223> AAEL015006-PA <400> 5 atgtctgcta aaagagctgg aggtggatca ggagggaaat tcaagatctc gacagcatgt 60 cctgtcggag cggtcatcaa ctgtgccgac aataccggtg ccaagaatct cttcgtaatt 120 gcagtaaaag ctatcagagg acgtttaaac aggcttccag cggctgccag tggtgatatg 180 tttgttgcct cggttaaaaa gggaaagcca gagctgagga agaaagtcat gccagctgtt 240 gttatccgtc aaagaaagcc ctacagaaga aagaatggtg tcttcatcta ttttgaagat 300 aatgcgggag ttattgtcaa tgttaaaggt gaaatgaaag gctctgcaat tactggccca 360 gtttcaaagg aatgtgctga actctggcct agaattgcat caaattctgg aagtattcag 420 taa 423 <210> 6 <211> 801 <212> DNA <213> Artificial Sequence <220> <223> alkylglycerol monooxygenase-like <400> 6 gtacacattc agtttaatac tttgtatcaa ttttggatac acactgagat ggttgataaa 60 cttccagcac cgttggaatt tattttgagt acacctagtc accatagagt gcaccatggt 120 cgaaatccct attgcattga caaaaacttt ggtggaacac ttatcatttg ggatcgactt 180 ttcggaacat ttcagtccga aaaagaagaa aaagttattt atggtcttgt ttatctcgtg 240 aataattgga atcctcttta tatacagttt tgccatattc caaatttgtt agaaactttc 300 tggaaaatgg aagggtggcg caacaaactt tcagtgctat tcaaaggtcc cagttgggtt 360 cctggaagcc ctcgtcttgg ctacagagag aatctgataa agataaatta tccagttgaa 420 aaatatgatc gaaaagtatc ttttatcaca tcaatttaca ttactttgca tgtaatattg 480 ttgatcttga catttcaaga gctcgcattt aaaaaagatg cattgtcgta tggtcataaa 540 tgggcccatg gatgtttctt tgtcatgtca ttatcaagtc tgggatcaat atttgaagac 600 aaatcctatg ctcctcattt ggaaataact cgaagtgtca tttttatcgc aattgacata 660 ttctcgtcca ttgtcaattt tgatctacaa gtcattcctg aaaattcatt tttggtgcta 720 agatcaatat tcatttcttc gattctattt tggatattga tgattatatt tcaaaataaa 780 gaaaataaga agcagaagta a 801 <210> 7 <211> 774 <212> DNA <213> Artificial Sequence <220> <223> aquaporin 4 <400> 7 atgggtttca ttgatgaatt gaaggatgcg aaattctgga aagctgtgtt cgctgaattt 60 ttagcaacga tgatattcct gcttgtcgtt acgacagttg catgcgcttc aggcattgga 120 aaagttggta gcagcgcggc cgtggcagtg cagataggct tgggtatctc gttggccatc 180 gctactcttg cacagtgcat tggccatgta agtgggggtc acattaaccc tgctgttaca 240 gctggcatga tggcgattag aaaaatatcc ccactcaaag gaatattcta catccttgcc 300 caaatgattg gagcaactgc ggggtctggt cttggatacg ggttgatccc gtatgcaaac 360 agagcgacac ttggaaacaa tggtgtagca gatggcctaa atgctggcca ggcatttgga 420 ttggagctgt tcttcacatt cattttgatc ctgacagtct gcgctgttac agaccctgga 480 aagaaagtcg agccatatgg aacaacattg gctattggaa tatccattct cgtctgccat 540 gtttgtttga ttccatacac tggatgctca gttaacccag caagatcatt cggacctgct 600 cttgtgatga acatgttcga gaatcactgg gtcttctggg ttggccctat tctcggcgga 660 atattggctg cagtgctcta cgaatatctt ttcaaaacgg aaacaaaaca aggggatgac 720 agagcagatg tcagctcaaa taatgaaaac acagagttaa aaggaagagt ttaa 774 <210> 8 <211> 5067 <212> DNA <213> Artificial Sequence <220> <223> ATP-dependent RNA helicase DEAH11, chloroplastic <400> 8 atggacgacc ctgaaacgaa agttcgaatg agccagttcg aaaattttgt aaacgagttg 60 aagaacacga ggatatggtt tcatggcgca tcgctctatg aaacattaat aagggacacg 120 tcttgtatac gagatataat tttgtctgcg tcgagtaaaa agtcaaactc gatgagagct 180 gaaattgtca aaattaaaaa ggggaaaagc aaaaagttta tctcgctgga aaattatgca 240 acgaaaagaa aagtgttaaa tgcgctggaa gcagaagagg aagaaatgca aattcaaata 300 gaggaacata acacaaagat tgaaatgata ataaatgatt tgaaaatgat ggatttgccc 360 gaaaaaagaa gaatgaagcc atccaaatgt ggtgttgact tgattgccgt ggaatttctt 420 aaagaattta cgagaatcat caaccctctt ccaatttatg caaaacgttc agcaattatt 480 gaaattgtgg acaataacca atttgttgta ttgaagggtg aaactggttc aggcaaaagc 540 acacagttgg cacaatacct gatggaaaga ttctcaggaa cagcaaacag caaggttatc 600 tgcacgcaac caagaaaagt ggcagcaatc agtttggcta ggagaattgc tcaagagcaa 660 tttcagaaag ttggagaaca aatcggatac tgggttggaa tgaacaagtg cctgaacaaa 720 aacacaaggc ttattttaat gacggatagg gtgctgttga attattgtat ggagaatcca 780 caacttgatg gtgtttcatg cgtaattatc gacgaagctc atgaacgaag cttaaacata 840 gatttacttc ttggaatggt caaacatgca gctaaaggca acaaagatct gaaagtggta 900 gtcacttctg ctacaatttc aacgaagcaa ttctctgact atttctatgg atgtccgttc 960 atagaaatac ctggccgcat gtatccagta gatgtgatgt acgatgaaac agaaggtggc 1020 caggattatg tgaaaaaagc agtcgctaaa gcattgcacg ttcactgtaa tgaaggtcca 1080 ggggacatat tggtcttttt aacaacacca atcgaagttg ataatgcagt agaggcattt 1140 gctaaggcat ctccagacac taggtcatac atagtgttgc cactacacgg taagctgcag 1200 cctgaacaac aaatgagggt tttcaaagca tgtcaacaag ataagagaaa aatcgtcttt 1260 tcgacaaatg tagcagaaac gtcagtaacc ataccgggaa taaaatttgt tattgacagt 1320 ggaagggtga aggagaagtt ttatgatgct aaaaagggcc taagttacct tgccgtgaaa 1380 atggttagca aaagctctgc catacaaaga atgggtcgtg ctggccgaac tggccctggg 1440 gtgtgcataa ggttgtatag caaaagcgac tatgacagtc tggaagaagc gacattgcct 1500 gaaattaaga aaatgcatct cggatcagca gtacttagtt taatggcact tggaattgat 1560 gatgtaatgg gattcgactt cattgagaga ccagatgagg caagtctatc aagtgcaata 1620 agtgttttga aaatgttggg agcaattgat gaggtctgca aattaacgac aaagggaaaa 1680 aacctcgcaa aactgccact tgagccacga gctgggaaag tagtattgga cggagtccaa 1740 gctggttgcc aggaaaatgc tgtaaatttg gcagcagcga tggtctcttc gtcgagtgtt 1800 tactttcgac ctggagagga tgagaaaaag aagttatcag atgaggctaa agtgaagttt 1860 tgcaacaaag aaggcgattt gctgagcatt gtcgacatct ataacggttg gaagaatcaa 1920 catgacaaaa aggcgaagaa caaatggtgt agtagcaatt acataaatgc aaaaacgatg 1980 cgttcaatgt cagaattgat tagcgagatc aattttgcat taaaagatat tcgcattcaa 2040 aaatcggaca tggcaccaaa atcgcacgaa gagaagcaag cttttttgaa agatctccta 2100 atttcggttt attatgacaa tgttgcattt ttcaccggtc atagtagaat cggttattgg 2160 agtccgaagt ttgctgagcg ctttttcatc catccctcat ccgtttttgg tgctcttgcg 2220 atgcagccgg aatttgtcgt gtttcaagat gtccttaaaa catctgcaaa ttttatcact 2280 ggtgtcaccc cagctaataa gctatcactt gagaatcttt gtccaaacaa acgttattct 2340 attgatttca accaatttga agcccataaa gtcatagaaa tggtgctgtt tccagttgga 2400 ccctctgttg ttagggccct gattggtaaa cgttgggaga cgaaaaaagc attggaagct 2460 ttgattacag atgagggaaa agagccaggg ctgcttgaga tgagtgttga cgaaagaaaa 2520 gtcgcgatct tcacatcaga gaaaagaaga gaaatggccg agaaattaat gaaagagcgc 2580 ttacatgaac agaatcaatt aatagagaga gaaaccaaaa ctgaagattt aggtccagaa 2640 agaacggggc atcgcgttgt gattgcagcc ggcggtgaaa ttcaagagat tctccagccg 2700 tcggaatcgt gtaagttgga agtagaggta aaaaatagat ttgcaaatga tgtcattaaa 2760 gcagagatat tgaaggaaat ttcacaagag atatcagcga aactcgcaag tattaaaggt 2820 gtaaaacaca tcaaggaaga aacaaggaat acaccaaata tcatcaaatg gggacagatt 2880 tcatttacta aattagaagc attagaggac gcaaaaaagg gacttaattt tgttgcaaaa 2940 ggatatgaaa ttgaagcaaa acaatctaca tacaggggtg atagcagtga ccaatcacgt 3000 gtgagaatca cagttacgtg gtcaagaaga aaatcacgag ggtttggatt cgttaaactc 3060 agatcaagag acaatgcgtc aataattgcc caaagcatta aagaagttta tgcatgcaat 3120 tttgacaaga aggacataat gcaaatacac gtgaagaacg ttgatcctgc tctagaaaat 3180 gaggcattca gaaaatcaat tgaaatgtat gtaggccata attatgcaga tgacatagtt 3240 gatgtctaca tagtgtacga gaaagccagt aatgctaatt tagaaataga gacccaaggg 3300 tacgaaaggc agatcagaga gcgacttcat ggaattccat gtgaatcgtt gtttatgttt 3360 cctataaaga aagaacaatc aatctattgc aaagcaaaca ttgatttcaa gcgttttgaa 3420 catgcacagg aggtggtcgg ttatttgaat ggaccaaatg ttataggaac acaaatgtgt 3480 cactcggtca ttgttttgaa gcaacagtta ttctgtacag caatcatctt tgaagcaatt 3540 gcaacggaaa ttgatgaaat catgacgtta acaaagaaat ctaccaacaa aataactgtt 3600 caagacgcca aggaaaaggg tgccaagatc attaccatct ctggtgaaga ttcttccact 3660 tataaagtga ttttctgtcg cctccaagat cttattaacg gtgagatgat agaaaacttc 3720 gatgtatctc aggtgtccta caacgcaatg ctgagacaag tccaaagctt ggaacgaaga 3780 gttggccaag ttaagatcga atacgataaa agacatagga aatttcgagt ttatggcaat 3840 ccaaaaagga gaaaactgct aaaagatgga ctgggaaaga tacgcgctga catacgtgcg 3900 aataaagaga ttaaaataag tttaaatggc aaaggaaaga agcctggttt aatgaaggag 3960 ctaatgagac gatatggacc ccgtctgcag aaaatgatgc cttcaagcaa ttttggtata 4020 attgagttga acatacgtca tcaactggtc catgtaacag cccctgctga agtgacagat 4080 agcgtactca gccacgtgaa taagtgcaat gaagagcttc ttgacgccaa cgcaactgca 4140 catgatcaat ccgaagcaga cgacaacaat tgtccccttt gtctgtgtga acccgacgct 4200 tcaatctaca ttttacagtc gtgtggacat gcctattgct ccgagtgtat cgatcaatat 4260 ttcgaatctt gcatgaatga taaaaatttc ccaatcaaat gctgtgtgca aagttgtgaa 4320 agaaatctgg ttataagaga cctcgattta cttactcata gcaaagagca aagatttcgt 4380 tttatgggag ctgctgttgg ttgttttgtg acgaaaaatt caaagagtta caagtattgc 4440 ccgacaccag attgtagtat ggtgtatcgg atatcagatg aacagaatgc aaaggccttc 4500 tactgttctt tatgtacgaa ggcaacttgt accgggtgtc atcaaaacgc ccatagcgga 4560 tttcagtctt gcattgcctg gaaaacatac aaagatgacg aacatgtgtt tgactgggct 4620 aaacaggtgg acgcaagaca gtgtccaaaa tgctgcacca tgatcgagaa aaataaagga 4680 tgtatgcacg tggcttgcaa atgtggagcc cacatttgct ggaaatgcat ggaggtgttt 4740 caatctggtg agaaatgtta cagccaccaa acgttctgca aagggaaact accacaacaa 4800 ataaaccgca ttatcccaca agcaagaaca atgtctgaaa ctatgaacat taatgctaca 4860 gtgcaactgg atgcaaccag acgtacttcc cagaacagtg gtaatcacgg tgctgtggtg 4920 caacgggatg caccacacca agataccgca agacgtacag ttcagtatga tggtaatttt 4980 ggtgagacgc agcgggatgc agcaagacgt acatttcagt acgatgataa ttttagtgca 5040 acaatgcaac agggttcggc aagacgt 5067 <210> 9 <211> 1287 <212> DNA <213> Artificial Sequence <220> <223> ATP-dependent RNA helicase eIF4A <400> 9 ggagttcagc catcctttca gccgatagaa aagtcatgca acatgtccac tgagaagact 60 aatacaagtt ctgaaccacg tcaagacccc atcaaccctc ccacagatgg ggttgatgaa 120 attgagtcca actggactac ggtctgtgaa agttttgatg atatgaatgt gaaggaagac 180 ctccttagag gaatctatgc ttatggtttt gaaaaacctt ctgcaatcca gcaaagagca 240 attgtacctt gcattaaagg ttatgatgtg attgcccaag ctcagtcagg gactggcaag 300 actgcaacat tttcaattgc cattttggag caacttgaca ttaatccaga taaggatgtc 360 agaccaaacc ttcaagccct tgttcttgcc ccaaccagag aattggctca gcagattcaa 420 aagaatattt tggctctcgg tgattacttg tctgtcaaat gccatgcatg cattggtggc 480 acaagtgttc gtgatgacat gctcagactt gaacaaggca tccatgtcat tgttggcact 540 cctggacgtg tctttgatat gattgagcga agaaaactta atgtcaatga tattagaatg 600 tttgttttgg atgaagctga tgaaatgttg tcaagaggat tcaaggacca aatctatgac 660 attttcaaga agctcccccc taacatccag gtcattttat tatctgccac catgcctagt 720 gatgtcttgg atgttacaac aaagttcatg agagaaccaa tcagaattct cgtcaagaag 780 gaagaactta cccttgaagg tatcaagcaa ttcttcattg ctgtagataa agaggaatgg 840 aaactagaaa cattgtgtga tttgtatgac acattgtcta tcactcaagc tgttatattc 900 ttgaatacaa gaaggaaagt cgattggtta actgaaatga tgaccaaaaa ggacttcact 960 gtgtcctcac ttcacggaga tatggaccag aaggaaagag atttgatcat gagggaattc 1020 agaagtggct ccagtcgagt actcatcacc actgacttgc tttcacgtgg cattgatgtt 1080 cagcaagtct ctctagttat taactatgat cttccaacaa atagggagag ctacattcac 1140 agaattggac gaagtggtcg atttggtcgt aaaggtgttg caataaactt tgttacaagt 1200 gatgatattc gtctattgcg tgatattgaa gcattctata atacatgcat cgacgaaatg 1260 ccaatgaatg ttgctgacct catttga 1287 <210> 10 <211> 672 <212> DNA <213> Artificial Sequence <220> <223> axin interactor, dorsalization associated <400> 10 atggctgaat gtaacatcac tcttactgac atggaaagac tcagacctct catgaaaaat 60 ttatcaggat ggcgtggacc atttccatta tcatttcaaa cagacattgg aagtgaaagt 120 aaaagttcaa cctcgaacag tcctcagagc tggcgttcca cttccacgaa tgaggtcaat 180 gatttgcaat tgttgcagtc gggcctgcct ccaaggttac cggcccgtcc aggatacaga 240 aggcttgcta tcaagataaa cagtattgga ttaaaagatg cttctttgct tatgcaacct 300 tgcattgttg tatcaattaa agataatgtc ggtataccca tagagactga tcaaattgtg 360 tcttcgccaa tcaagactga accaacgtgc ttacatttta accaggccat cgagatacaa 420 cgatacattg agaaatttta caaaggaact gcaatatttt tcgaaataaa acgttgcaag 480 aatgataaat cccgactact gagcacaaaa tgttactcat ttattgaacc agatttaata 540 aaacctggcc caacaagttt gagattatta aaaaagccaa tagactactc aaggaggcga 600 atgatttttt tgacgaaaaa gccgttatat ttaaatgttg aatttataat acacgacgaa 660 tttagcaggt ga 672 <210> 11 <211> 1455 <212> DNA <213> Artificial Sequence <220> <223> axoneme-associated protein mst101(2)-like <400> 11 atgcacggta gacagatttc ttatgcgatg tgttctgttc tgccctgcca catgtggcgc 60 ttcctattca cagttggttt tttggcaatg ttaaaccgca tttctgtggg atcagagcag 120 gccttgtttc aacagaagtt gttttacata aaggaatacc ttaacttcga cttcacgaca 180 ttttggacgt ataaagaccg ttatgcgtcg cctgcgcagc tcggtgcgag tgtacagctc 240 gtgcagaaat ccgtagcaaa tcttggcgac gagtcacggc tacaacgctt gttagtccat 300 ggcctacgtg gtcaaaagat ctcgatgatt gtagtgggag ggtcgatctc taggggagca 360 ccgtttattg aagaaggtag cgttggttcg tggatatatt ttaatgccat tgctggatgg 420 tggaatacca tgttcaaaga tataactggc tctgtaatgg agatcaacag tgttagtctc 480 ggtggcatag gtactgacta tttttcatat tgtttagata gtcatgttgg cgaaacttcc 540 atgccagagc tgctcatttg ggagctgtct gccaatgact acaatcgcta tgcagataaa 600 ccgtttaacc caggcgaacc gttggaacaa ttcacgcgca atgccctgcg acgttcatct 660 aggcccgcgt tgctgttctt gaattttttt cgcggtgctg acgctgggtc gaaaaactgc 720 ccgaattacg aagactcagg cgaactcgat gtagccaggt attataacat tacgtcattg 780 agttggagaa actacgtttg cgattacatc cagctgcacg atataaattt tggtttcaac 840 gccacttttg cgacagatca ttttcatccg agtattcttg ggcatgcaca gatggctttt 900 attgtcatca actacctacg aaacgcattt ttgcgcgtgt tgcgaggtcc cgcgggactg 960 gctacgaccg atgaatcgtt tcgcgacctc gtagacaatg ctgcattcac attgccacca 1020 gttttgtatc cagatacgat aaatggtcag ccactttgtt ttacctatct gcaaagtaat 1080 attaaccagg agctgaataa cagcctcagt tgtgttgtca ccaggcaaga tgactacaaa 1140 ttcaacattt tcaaacaatt caaaattagg gaggataaat tcggtggcat gcagacgcac 1200 gtttcagagc aactgattca atttctcgtg catctcccgc gctttttctc gcgcatggtc 1260 ctcgtctcgc atgcgaccag cgggtcggcg caggtttggc ttgatcatca gacccctgtg 1320 ctcataaata cggaaaatta tcacatgggt acgttgctga cagaaatctc cacgaacata 1380 cagcctggaa agcatgttgt caatgttttg tctttgaaga acgggttcgt cgtatgtgcc 1440 attggtgtgc tttga 1455 <210> 12 <211> 1242 <212> DNA <213> Artificial Sequence <220> <223> balbiani ring protein 3-like <400> 12 atggcgatgc ttcctatcat tgcttcagtg atgttaaact tggtttgttg tacttatcag 60 aactatgctg tcgaggacat gacgaacatc attatggcgg gaaaatcctt cacagatgac 120 gccatccagc gtgttttcct attggctcct gatattacca aggttcgtac ggtcgagaca 180 cgaggaagct atttcgaatg cgtcgacaaa ctggacaagc gatcctgcca ttatctcgca 240 tctcttggag catgtaacac acgccctatg cgtatgaaga ctttttgtca aagatcttgc 300 gggttctgtg ttgatcctcc gtgtaacata tctaaatatg gctgctgttt tgatggcaag 360 actcttgcca gaggacccca catgcaagga tgctctgacg attgcaaaga tgctcttggt 420 aaagcatttt gtcgtgttct caaaagaaat ggccaatgtt atgaagctgg attacagatt 480 cgcagaaagt gcgcagtaac ttgtggatat tgtagaccat gtgttgatga ggaaccatat 540 cgttgtctta tggcttccaa gtacaaccgt tgctcctcgg gcaaaaagag tttcttagat 600 gtttgtcgaa ggacatgtgg aatatgtggt aagaaagatc cctgccacga ttttgcttgt 660 ccccaaaact ccgtatgtcg aattgacgac attggtaagc cgtattgcga atgtgatggg 720 cactgcagac ctggtgacca cttcactgga gttgtctgcg gccgagatga cacagaatac 780 aagagtcttt gtgctttgaa aaaaagaaat tgcgggagcc cagaaactcc tcctgtcact 840 gttagaaatt atggaccttg tgaaagaggt gttgcattct ctgatcgacg taaagtctgc 900 gaaaagagac gtccagtccc aaagctttgc atcaaatggg aagctgatgg ctattgtaca 960 acgcgcagga actccatgag gaaagtgtgt ccccaatctt gcaatttctg tgcggttcaa 1020 tttcccagag catcatgcag atactcaaaa cacggttgct gtctcgataa ccgaacacct 1080 tgcttgaaca cgagttacaa aggctgcccc aaattaccag cttgcaaaga ctttgcaaag 1140 gtattctgtc gccggtttac cgctgtttgt ggcacaaagt tgcacaaagc taccatgaga 1200 cgctattgtc ccaaagcctg tcacctttgt ggcacatcat ga 1242 <210> 13 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> calmodulin 1 <400> 13 acaacgaaag agctcggtca ggtgatgagg agtctgggac agaacccaac tgaagctgag 60 ctgcaagaca tgatcaatga agttgacatt gacggaaatg gcacaatcga ttttcctgag 120 ttcctcaaca tgatggctcg taaaatgaag gacacggaag gggaagagga gatcaaggaa 180 gcatttcgag tgtttgacaa agatggcaac ggacatatca gcgctgcaga gctacgacac 240 atcatgacga atctcgggga aaaactcaca gacgaagaag tggatgaaat gattaaagag 300 gctgatattg atggcgatgg acatatcaac tatgaagagt tcgtgcggat gatgatgaaa 360 taa 363 <210> 14 <211> 387 <212> DNA <213> Artificial Sequence <220> <223> carnitine O-palmitoyltransferase 1, liver isoform-like <400> 14 atggcattga tcggcacctt tttttcactt ttcgtcatca gcagaggtca aggatacgac 60 agtgcgtttt tgcatgatgc cttgacgttg ccatggacac tgtcgaccag ccaacaacca 120 caacaacaga tgaatcgtgg gtttgacatt gggatacctg aagtcagaga gacgatcagt 180 ccgggcggtg gctttggtcc ggtggctgac gatggctacg gtgtttcata catggttccg 240 gatgaccgga tcatctattt ccatatatca tcaaagctct cttcgccaaa gaccagagcg 300 tcgagattca tgggaaacgt atttgcaagt ctgtccgagt tgaaatcact gcacgaagcc 360 gcaaagttaa cccggacggc aaaataa 387 <210> 15 <211> 1479 <212> DNA <213> Artificial Sequence <220> <223> cell cycle associated protein 1 <400> 15 atgccaagtg cttcatcgaa atctgccgca atgtcttctc aagtacctag tcttgaagga 60 caggatccgc tgaaagttgt cgtctcaatg atggagaaga aagttagaaa tctcgagaag 120 cggaagacaa ggctggtttc ctacactcaa caagttgaag aaggaaaaaa actagttgaa 180 aaggatcagc aggatgcagt gaagaagatt gaatttgtgg aaaacagtct tgagcttgct 240 aaggagttcc atcagatttt cagaatgatg gaacaagagt acattaagtt gcagaagaag 300 gaacagaaga gagccaagtt ggagatgaag gagaagggct ttaacgagag aaaaaagacc 360 gctacacaga tccttgaagt tcagacgctg cttgagaaca tcgatgatga cgtgaaagag 420 gactttcgca atggaactga aggagcttgc aaattggagg aggaggactt agcgaggctt 480 gatgaaatct acaagctgat cactccaagt cagtgcgaag atacgaaggt catgaaggac 540 caggtcgcgg catcatcaat tcatcttcac aacttacttg aggagaagga tttgcctgta 600 attggcacaa cttataagca attatatggc atcctcaaga agataaagga gtgtgggtat 660 tttgataagt ctgaaaaagt agaagaagaa gcagcaagtg cacctgttga ggacactgcc 720 actgaagaca gacagccagt tgtcgaagca gaagaggcag tcactgaaga caaagatgat 780 ggacagaaag aggaaggaga tctcacaact gaagctagtc aacctgaacc aggctacaac 840 gctactcccg cagagccatt gttgcaggaa ggcatgactg aagctgttga acctgaactt 900 gttaatggcg ttgatttacc tgttgagttc agtgagccag ccggagattc tgctatcaat 960 tttctcagct cggaagttca agtgccagca gctgatgtag aaagtgaaga ggcatctgca 1020 gaagagggca agttaaatgc agcgagccca gaattcattc caagaagtct gcagagtggt 1080 cagtcagaag aatctggctg ggttgaaggt gaaggcaatg aggctggagc agagaattca 1140 ggaagtgatg gcggatggca aaatgtgaca acatcgagtg atgcacatca cgcgcaaaac 1200 cgaagaggag ggcatagagg cagggacaga ggggggttca gaggggggcg tggtgaagga 1260 cgaggtggtc gaggtcgtgg tggatacggt cagaacaact accatcagag acaggagaga 1320 ggagacaata atcaaaggcg tgaagggggt caccccagag gtggaagagg cggacgtggt 1380 ggtcacccga gaggaggaag gggagattcg cgtggagccc cccgtggaaa ccgaggcgga 1440 tacagcagac cccaacaaca acaacaaccg caacaataa 1479 <210> 16 <211> 408 <212> DNA <213> Artificial Sequence <220> <223> cell wall protein PRY3-like-1 <400> 16 ggtgatttcc agaaagaagt caacaaagga tcatttgaaa atggcatttg tgacaaactc 60 gatgaaatga tggacaaagt tggctcaggt ggtggttcca aacaggcaac tgttaaaatt 120 tcgaagggca aagggaaggt aattactggt ttcgctgagc aggatgttaa acatatagct 180 ggaaagacac agaagtggca aggaagtcag ggtgctggcc aaggacaaca aggtggccag 240 ggacaacaag gtggccaagg tgatggagaa gctaagccag aacaaagcag tgaacaatat 300 tcgaagaatg gagaggaagc tcataacatg tttcgcaaga ttcacactgc caaagatatg 360 aagataaatg aagaaatgtc aaaagcagct gaggaatatg caaagaaa 408 <210> 17 <211> 783 <212> DNA <213> Artificial Sequence <220> <223> cell wall protein PRY3-like-2 <400> 17 cttgctatga aatgcacaag tgaaaaggga gttgaaatga cagccgaaga agcaaccaaa 60 aattggtatg gtgaagtttg cgaacctggt tacaatttcg acagtggttc attctctggt 120 ggtacaggcc atttcaccca agttgtttgg gacaaaagtg ttgagcttgg aattggaaga 180 ggaacaacag aagaaaatgg aatgttttgc acatatgttg ttggtagata caggcctgct 240 ggaaatatga tgggcgattt ccagaaagaa gtcaagaaag ggtcatttga aaatggcatt 300 tgtgacaaac ttgatgaaat gatggataaa atttcatcgg gtgatggttc gagaaaacaa 360 caaaacaaga tgaagttctc ttcagaccaa ggtaaagtta ttactgggtt tgcagaagga 420 attccatcgt ctggttataa ggcagcaaac tcgctgcaga agggaaggaa agcttggcaa 480 ggcgataatg gccaaggtca gggtggtgga ggagaccaag gaacacaaag cagcgaagaa 540 tattccaaga atggggaaga agctcataac atattccgga agatacatac tgccaaagat 600 atgaaggtca acgaagaaat gtcaaaagca gctgaggaat atgcaaagaa attagcttca 660 tctggaagtt tccaacattc aagcagagac gaaaggaaag gtgatggcga gaatcttgct 720 atgaaatgca caagtgaaaa gggagttgaa atgacagccg aagaagcaac caaaaattgg 780 tat 783 <210> 18 <211> 711 <212> DNA <213> Artificial Sequence <220> <223> cell wall protein PRY3-like-3 <400> 18 cttgctatga aatgcacaag tgaaaaggga gttgaaatga cagccgaaga agcaaccaaa 60 aattggtatg gtgaagtttg cgaacctggt tacaatttcg gcagcggttc attttccggt 120 ggaacaggtc atttcactca agttgtttgg gacaaaagtg ttgagcttgg aattggaaga 180 ggaacaacag aacagaatgg aatgttttgc acatatgttg ttggtagata caggcctgct 240 ggaaatatga tgggcgattt ccagaaagaa gtcaagaaag ggtcatttga aaatggcatt 300 tgtgacaaac ttgatgaaat gatggataaa atttcatcgg gtgatggttc gagaaaacaa 360 caaaacaaga tgaagttctc ttcagaccaa ggtaaagtta ttactgggtt tgcagaagga 420 attccatcgt ctggttataa ggcagcaaac tcgctgcaga agggaaggaa agcttggcaa 480 ggcgataatg gccaaggtca gggtagtgga ggagatcaag gaacccaaag cagtgaagaa 540 tattccaaga atggggaaga agctcataac atattccgga agatacatac tgccaaagat 600 atgaaggtca acgaagaaat gtcaaaagca gctgaggaat atgcaaagaa attagcttca 660 tctggaagtt tccaacattc aagcagagat gaaaggaaag gtgatggcga g 711 <210> 19 <211> 1227 <212> DNA <213> Artificial Sequence <220> <223> chitobiase, di-N-acetyl- <400> 19 gatttgtttc tcggaaggaa gttcgacgaa aaacttccgc gcattgaagt tgatcaaaag 60 tgcaaaaaaa ttgacgacgg cgattgcaga atgaagctgc atttcttttt aagtaatagc 120 tgtttacttt caatactatt tgtatcatca tgcctgtcgt ttgagagact ggaaaatgaa 180 actgaggaca gctgtatatg caaggacaag tcattgtgtg ctgctctgaa agttgggcct 240 agacaagaag tttatggctt ttccacagag tcgtcaaact ggaaacatta cgactgggaa 300 aaaatcacaa caatttcggt atttggaaaa tgggatcctg aaatgttatg ctacgctcat 360 tcgaagggtg tgcgattgac tttgaagttt gactgtccag tatcaaagct tgttgatgaa 420 ggatatcgca aagaacagat aaatgctgtc cttgaaaagg caaaaagcct ctatgccgac 480 gggattaaca tagatatcga acaaccagtg aagcaagggt caccagaaga aaaggcaatg 540 actgacttct caaaggaaat tactgaagcc tttcacgctc agattcctgg ctcacaggtg 600 acagtggatg tagcatggtc cccaaagtgc atagactctc gatgctatga ttatgcgagt 660 cttgcaaatg ttacagattt cttaattgta atgtcttatg atgaaaggag tcaaatattt 720 ggagattgta tagctggacc caattcagct taccagatta catcacaagg tataacgaaa 780 tatttagctc tgggaataga ttcaaagaaa ctggttcttg gtctgccatg gtacggctac 840 aattacccat gtattaaatt ctctggcaga aatagatgtg acatcaaaaa agtgccattt 900 cgtggagtga attgcagcga tgcagctggt cgtcaatact gctattcaag cattttgtca 960 gaatttcttc ccaaagcaat aggcggacga caatttgacg acgagagcca atctcctttc 1020 ttcaactaca gagatgcaga agatgatagt atgcaccaaa tatggtacga tgatcctcag 1080 agcctcattc tcaaatatca acatggcatc agagatttca atctccgagg attagctttc 1140 tggaacatcg attgcctcaa ctacacggac tctgctaaag caaaggcaga aacgaagaaa 1200 atgtgggatg cagtgtttgt caactga 1227 <210> 20 <211> 1458 <212> DNA <213> Artificial Sequence <220> <223> cholinergic receptor, nicotinic delta <400> 20 atgcatgtct caaggtctat attgttgcca atcgtacttt tggttctatc atcatcattt 60 gccttttgtg acatcgatat atcaccacaa gaacagttaa ttataaagtt ttttggtcca 120 gaaagacgca tggctgatgt tttgccaaaa aagaactata ctgataataa tccaattaaa 180 gtccatttgg ctttccttat tactcagatt tacgatattc aatctgacca agaaaaagca 240 gaccttggtg tttgggtttc aatgaagtgg aaaaatcagc taataagttg gaatgcgagt 300 gaatataatg taaactatct tgaagtgcca agcaactaca tttggtcacc gaagatgtac 360 ataaaacaga ctgctgaaac caagatgtta aggcctgatt ctcattcatc aatggtaatt 420 gttttacctg atggatcaat gcaactggaa ttcggaacaa gattgaaact atcctgcgca 480 atgcctgctt gtctcttccc cattgattct cacaagtgtc cgctcaccat cctatccact 540 gctcaccctt ccaaaaatgt ccttcttgtt cctgatccgg agtctcagaa aagatacgaa 600 cctttttcaa agaatagcac aggcctctgg tctctcaaag ttgaagattt caaagccgca 660 gacaatgtat tcatgctgtt ggataataag cccatgccct cctctttatt gcacacaaat 720 atcaatttga aacgcaaatc tacttattac tggttaacga ttattgctcc gataaccttg 780 ctttatctca ttacattcgg tgctgttctt ctgccgagac aaggcgggga aaggagtacg 840 ttactagtca cggtcatgtt ggcacagatt gtttttctcg atacagtgtt aaagaacgta 900 ccgaaaacgt ctgactatat accgatcatc gtatcgtttc tcgcggttgt gttggtcttc 960 acggtcttcc agattagttt aaccgcggtt gtgtcctact acgcggaatt ggcctgcaag 1020 tcaaagaaga tgtccaagtg tcatggcaga tttattgatc ttgtcagcaa gattttcatg 1080 tgcaacaaaa aggcgaacaa gaacaaaaat aaagtcggtc agacacaaga attggatgaa 1140 caagaaaatg gcctcaaaca gaaagcatcg ctcgatttgt atgaccatga tgaagatcat 1200 gatagtccat cgtcaccacc agcatcaaca acaacaacaa caacaacaaa tgttgcatct 1260 gtgaaggaag acaatacttc atgtgagaga gataaagaga aagacgagct cgataagcgg 1320 cggagtgcat acaaagcaat gtgcaatgct atggagcggt tctcaatctc catctcgatg 1380 acttttttca tactttcacc tgtcatattc gtgctaattt acactggtgt gctcaaatat 1440 gaatgcgccg tgcagtga 1458 <210> 21 <211> 945 <212> DNA <213> Artificial Sequence <220> <223> chymotrypsinogen B-like <400> 21 atggatggtc tggggttttt cattttaagc atttgtgcct ttggcattgt agcaaatgtg 60 gaagcttgtc gtgatcgttc tcatggttgc cctcgatgga aacaaaaagg atattgtact 120 gctgagagat acaaaaaaat aatgaagata tattgcccct tttcctgtgg ctattgtgga 180 gatgctacaa caacacaaca accaataaca acaaaaccag gaacagctaa accaccagta 240 cctgcaatct gtggtcagcc agaagttcag caaagcagag tgatagctgg aattaatgcg 300 acaaaagggt cgtggccatg gcagatactt atgatattct ttggaagccc aatgtgtggt 360 ggatctattg ttgctccaaa ctggattgta actgctgcac actgtgtatc tggatatgaa 420 cgttatgtta gatacttcag agtcagagtt ggagaacata taacttcaac cacaaccgat 480 ggacagcatc aagatattca agtcgagaaa attatacgcc atccatcata ttctcgaaga 540 ttgctcaaca atgacattgc tctcatgaaa ttgaaaactc caattcaatt tggcaaatat 600 gtcaaaccag tctgtcttcc agaccaagga caaaatgtcc cagttggcac acaatgctac 660 ataactggtt ggggaaagat taaacaccca ggaaatatgc atcacacttt gcaacaagga 720 aagatgccag ttgtatcaaa acaaacatgc acaaatatga acacaagaaa ccttggcatt 780 cgaataacag accagatggt atgtgctggt cacggtggaa caactcgtgt tagtggctgt 840 catggagata gtggtggtcc atttgtttgt cagactggca ctaatggtgc atgggtattg 900 catggtgcag tgagttgggg aagtggcaga tgtgatgcaa ctcaa 945 <210> 22 <211> 4236 <212> DNA <213> Artificial Sequence <220> <223> collagen alpha-1(I) chain-like-1 <400> 22 atggaagtca ctaccaaagg agtttactgg cttttgcttg catttctcgt agcctcagcg 60 attgcccaag acggcgaagg agttccgaaa attcctggac caaagggagc caaaggacaa 120 cctggcgatg tgggaccacc tggtttagat ggagatcctg gagaccaagg agataaagga 180 acaaccggtt tagctggagc tgatggtgat gaaggttcag aaggtgatga aggaccagtt 240 ggacctccag gacctgctgg aactaacatc tctaccgaaa ttacaatttt tggacctcca 300 ggaagccgtg gaccaattgg cccaactgga caacaaggac ccaagggagc caccggcgaa 360 ccaggagagc ttggaccacc aggaccacgt ggacctccag gaccaaaagg agatactggc 420 ccaaaaggac ccaatggaaa agatggtgca gctggaccta aaggagaact cggaagaatt 480 ggcagagttg gacccgttgg aaagcccggt ctaagtggac aagctggaaa tgtaggaaac 540 aaaggtacaa agggagatgt tggctcagtt ggacgcaaag gagagaaggg agattctgga 600 aaacgcggcc aagatggtgc tccaggtttg gctggaaaga aaggaaatgc tggagagaca 660 ggagcagctg gtccacaggg ttatcctggc tccagagggc catctggtgg cattggacca 720 attggtaaag atggtccaga tggaccaact ggtgccccag gcccaagagg tccagaaggc 780 tctgctggcg tcctaggtcc agctggggct gctggagatg ccggaccaca aggaaagcag 840 ggacctgatg gaagaagagg tgaaccaggc tatgctggaa tcagaggagc cccaggagat 900 cctggaccag tgggtgccgc tggtgaagct ggaccagttg gagcagcagg acagagggga 960 cccacaggac cacctggatt cagaggcaac caaggagcta gggggttgac gggaccacaa 1020 ggaaagcgtg gtggacgtgg accttcagga ccagctggtg aatctggtgc atctggtgat 1080 gttggaccaa agggagtcaa gggatcaaag ggacaacgtg gtctgagagg tcaatttgga 1140 cagcaaggat ctgctggacg aactggacct gatggaagac ccggaccacc tggaccaact 1200 ggacctggtg gatcaagagg atcccctggc cgaccaggac ccccaggatt aaacggattc 1260 cgtggaatca agggacacaa aggagccaag ggtagccttg gtccagatgg agagaaagga 1320 gacaggggaa cccaaggaaa gaagggagct tctggcatcc gtggaccaag aggaccacct 1380 ggccagactg gagcaccagg attggaagga aaagatggtg catcaggtta ccctggtaaa 1440 gatggagaaa ctggagcacc tggacaagct ggaattcctg gtatttctgg agaacctgga 1500 gcaccaggag ccaagggaga tggtggctac cctggtagag atggagaacc cggctttgat 1560 ggtgaaccag gtgaggctgg agaccgtgga ccagctggag cacctggcaa gattggacca 1620 gttggaaaga agggaccaag aggagagcaa ggagaacagg gacgaagagg aaaccaagga 1680 ccaatgggta aatctggagg acctggacct caaggacgtc aaggaaagaa cggacaaagg 1740 ggtgcagctg gacaaccagg aaaagacggt ggtatggggt caccaggtga acgtggattt 1800 agaggagaga ggggagctgt tggccaaact ggaccacaag gagctgccgg ccgcaaagga 1860 agtcgtggaa gatcaggacc aaagggccaa gttggagata tgggacccag aggtgatgct 1920 ggaccacaag gaccaatggg acaaattgga gcaagaggcc cagccggacg tgacggtgaa 1980 ccaggagacc aaggagaggg aggtcaacgt ggagacagag gtagagatgg acgagatgga 2040 tccagaggca atcgaggacg ccacggacct gcaggacttc caggaccagc tggtcgcagt 2100 ggagaagtag gaagagccgg accagatgga actccaggaa tccaaggacc ccaaggagcg 2160 cccggagacc cgggccttcc aggagagcac ggttcaagag gaccttccgg aaagtctgga 2220 cctaagggaa gcttgggtga gccaggctac aagggacaaa agggagacca aggcccacgt 2280 ggaccagctg gacgagcagg cagtattgga aaggctggaa acattggtgt tgctggagag 2340 aagggagctc aaggtttgac tggtatccag ggaccagcag gaaaccctgg acgaccagga 2400 cccccaggac cagagggagc agtgggagct attggacctg ctggaccttc aggacccgac 2460 ggacgacaag gacctaaggg cgacaaagga tcacagggat ccgaaggaaa gccaggatcc 2520 gctggaagac ctggactcga tggtgccaat ggaatcgatg gtaacgacgg aaaagacgga 2580 cgaagaggac ccagaggacc cgctggacca agaggaggtc caggaaatct tggattaccc 2640 ggcttgcccg gattgggagg tatgccagga agacaaggtg cccgaggacc aaagggagag 2700 gatggtatca atggacgtga tggagaagat ggagagcctg gtgaagaagg attggttgga 2760 gccaagggtg actctggtcc acgcggaaag ccaggacgag atggaaaacc tggtcgcaat 2820 ggaaaccccg gacaaccagg agctcgagga gacaaaggtg cacaaggagt tgatggacca 2880 gctggaatca agggattatc cggaaagcct ggtgctgacg gccccccagg agcacaagga 2940 gatatcggac caatgggagc acagggtaac tcaggagaac ctggcagcaa aggatcaaaa 3000 ggacttaacg gttatacagg acccgttggt gacccaggtg accgtggaag tgatggcgtc 3060 agcggaagga agggagacat tggattcatg ggcttcaagg gaaacaaggg ccttacagga 3120 ccaaagggca ctcgtggagt tcccggatac aaaggaaaac caggagagaa aggtggcacg 3180 ggacctgatg gagaccaagg cccaccggga caatcgggaa tcagtggacc catgggaccc 3240 ccaggaaaca aaggaaatcg tggagcaaag ggaccaaaag gattttcggg taaagatggt 3300 gttccaggac caccaggagc tcccggtctt ccaggacaac caggaccttc attccaggca 3360 ccatgggccg gcggccattt ggcagatcag tcccccaaag gacccacgga aggacgacca 3420 ggcggtcaat caggcggaga tggagatgaa cccccccccg ccgtcaaccc attttaccaa 3480 ttctacaaat attattcgag tgaaaagaaa gagaagccga ctattgaaga tattcagaag 3540 tatggtggca aattccaggc ccgaatgaac aaactgaaag agatgattag ccgcacggaa 3600 actcctgatg gcagcgagaa atacccagca agaacatgcc gtgatctctt tgcttaccaa 3660 cctgacttca agagcggata ttactgggtt gatcctaaca tgggatgcaa gagtgacaag 3720 atcaaagttt attgcaacat caccgagact gtcattgcca cttgcgtcac gccttcatct 3780 aaaatgatgg ttgaaaaggc caaatgggga agaaagatca ggactacagc ccagaaatgg 3840 tttggcgagg acctcgaact tgcaacgatc aaatacgatg cgattgagtc tcaattgtcc 3900 tacctcggcc acttgagcaa ggctgcctac cagactgtca cctaccattg caagaattca 3960 gttgcatggc acgatgcttc ctccaacaac cacaagaagg caatgaaatt caagggaatg 4020 aatgatcgct tgttcgacta ccattccgct ttgaaattcc aaccacgaaa gattgaagat 4080 ggatgctcga cgcgaagcaa caagtggatg aaatctgtct tcacattcga agcaagaaag 4140 aatatccacc ttccaatcct tgatttcgct gttgctgatg caaccggcaa agaatccagt 4200 ttcggattag aagtcggccc agtttgcttt gtctaa 4236 <210> 23 <211> 4218 <212> DNA <213> Artificial Sequence <220> <223> collagen alpha-1(I) chain-like-2 <400> 23 atgagttgca gctcaacaaa accacccaga cacttcttcg tcggcttcat aagcgagttt 60 ctcctccgag attcgccact ctcgaaggca gaaagcgcaa aacaacagtc gaatcgaacc 120 attctttggc tcaacaaagc ctggcttggt tattcttgcg aggaaccact ctctcgcatg 180 cgaaagccat ctggcgagat gagattttca aagcggctga acacagcgct atttcttttt 240 gcatctggat gtctgttttt cgttgctgat gcccagttca cccagacgaa ggaaggaaag 300 tgccccaccc cagaaaatgt tggaaaagaa tgcccaagtc ctgagaatct tgctgctgaa 360 tgtttgtttg atagtgactg tgctggaaca atgaagtgct gcactgatgg ttgtaccatg 420 aagtgtgcca atgttacaaa tggtcttccc acagcagcac ctattgttgg accgaagggt 480 caaagaggtg acagaggaga tacaggttct actggaatca acggcaatgc aggatcccca 540 ggaccaaaag gaatgactgg tgacaaggga ccacttggaa actcaggaag aaagggtaaa 600 acaggtcgta ggggtcgtcc aggtccagca ggtggatttg aaacacagcc aactattgca 660 cctggaccat tgaaagatcc taaaggacca ggacctggcg atgccggctc acttgttgac 720 acagggactt ctgtgaatca accagatgtc gggccacctg gaccaattgg aaagagaggc 780 gcaagtggac ctcttggacc tatgggagaa agaggtgagc ctggactcag aggctccgct 840 ggagcactag gagaacctgg tctgaaagga ttccagggac caactggtga acagggaact 900 gatggagctg atggactacc tggataccca ggacttcctg gccccgatgg tgaccaagga 960 ccacagggtt tgagtggaac tgcaggcctt gctggaacac ctggtcacaa agggttgaag 1020 ggagatcgtg gtgcatctgg agcaaaggga cctgcaggaa tagatggtga aaacggacca 1080 agtggaacaa atggacccga tggagattct ggcccaacag gagcaactgg accaaaagga 1140 ccaattggaa agacgggccc acaaggactc gttggaaatc aaggtccact tggaccaact 1200 ggtctacctg gctcacgggg tccacctgga cttcagggag cctctggaac agcaggaaag 1260 tctggaggaa agggagatgc cggcgcccaa ggaaagcagg gaggacgtgg tgaacatggg 1320 gaacgtggat catttggcgc ccaaggtcca aagggagttg gaggagacaa aggaccagat 1380 ggatctcgtg gatcgcaggg caccaaagga gaattgggag cagctggtgg gagaggacgc 1440 agaggaccca atggagagca aggaaagcag ggaagacgtg gtgctgatgg ccacatagga 1500 aacagtggac cagcaggacc acaaggagac aagggagctt tgggagaaag aggtattaaa 1560 ggctcgtctg gaaactcggg gaacccagga caacaaggac ccgttggagc agtgggcaga 1620 aggggcagac ctggaaacaa tggtccatct ggagaacctg gcgtagctgg agagactggt 1680 gcacctgggt tggctggaca acctggcacc cctggcaatg cgggagcaaa aggagaagct 1740 ggagataatg gacagcgtgg tggacaagga gctaaaggat cctccggtgc gcctggaatg 1800 aacggcgagt ctgggctaat cgggatcacg ggaccacgag gagaagatgg acaggctggt 1860 gtagatggaa agcaaggacc agcaggaaac cctggtactg acgggcgacc cggaggaccc 1920 ggaacacaag gactccaagg caagcgtgga cctcgtggac tagtaggacc caagggaagc 1980 cgaggaattg atggtgttga tggttcaagt ggtaagacag gagccaaagg agcgaaggga 2040 gctgcaggcc aagctggaca agcaggcatg gatggggcta tcggccctga tggtacggct 2100 ggtacgcccg gacgcattgg caaagttggt gagaatggac ccgctggtcc cgatggatct 2160 ctgggacctt caggtcccgc cgggtcagaa ggtttgcctg gcgagatggg agatccaggt 2220 accgatggaa aaactggcaa gaagggtgaa agaggaccag ctggtttgac aggctcgaca 2280 gggagaatgg gactgcgtgg tacacgagga acagcgggca aaggaggact tgttggggca 2340 gaaggtgaca agggtcctgc tggcttgccg ggcctttctg gttcgcccgg caaaattggc 2400 ccaaatggac ctactggctc tcaaggaata aatggaccaa agggagaaag gggatctcat 2460 ggcctaaagg gacagaaagg acaggatggc aaagatggtg ctcgtggacc cgatggacca 2520 gatggcacag cgggaacacg tggaccagca ggaccaaaag gaagtgaagg aagagatgga 2580 aatcgtggaa ctcaaggaaa gcgaggaagc tctggtccca aaggccaaag aggaagagcc 2640 ggaaaatcag gccgaaccgg agtagttggc caagatggag cctcggggcg caagggtgaa 2700 cgtggcgagc gcggagataa gggtgctgtt ggagctaccg gagacagagg accagatggg 2760 cctaccggtc aagtcggtaa ccttggatcc aaaggggaga tcggacaccg tggaaatcaa 2820 ggaagacaag gacaagctgg gttgactgga gagcttggtc ttgctggccc accaggtgca 2880 acgggacctc cgggtccagt tgggccaact ggctcggcag gaagagatgg atcaaaaggc 2940 gcccaaggtg aatctggttt tcctggagtg tccggtcttg ctggatcacc tggaaggaat 3000 ggacgtaatg gcatcaacgg tgaacctgga acagacggag aaagaggagt gacaggccca 3060 cctggacaag cgggactaaa gggagaacaa ggaccaaggg gattgcttgg aatttctggc 3120 ctatctggtt ctccgggaaa agtgggacag aaaggtgaac ctggctcaaa tggacaacat 3180 ggcgttgctg gtaccaaagg attagttgga gcacctggac ttgcaggacc atccggcccc 3240 gctggattac ctggaacaga ggggaaaccc ggagaagacg gcttgtctgg taccaatgga 3300 aaacgtggag ctaaaggtga gactggaccc gggggattcc aaggtgcgcc aggccaacaa 3360 ggacaggctg gtcaatctgg aagaggggga caaaagggaa acgccggatc tcctggagcg 3420 aagggatcta ctggtcgcgg tggccttacc ggtttgggag gagacagagg aaatattgga 3480 cttcagggca ggaagggagg caaaggaagc agtggaacgg aaggagcaaa gggagacaag 3540 ggctggcgcg gctacaaggg tgcacgcgga attccaggca tggttggaat gagtggagga 3600 caaggaaatg acggatcagt tggcccagga ggagcacctg gacaaaaagg atacactggt 3660 cgctatggcc cagatggtga agctggcgat cgtggaccag ctggtggtga tggcatggtc 3720 gggggtgcgg gaccaagagg acgaagcggc gaagatggat acggtggacc accgggaccc 3780 ccaggacctc ccggaccacc gggatcaagc agctatggag ccggttcaat cggtagactg 3840 atccgacccg gagcactcga caagggcaac ctatacggat atcaaggcta ttatcaacaa 3900 agattctata gagcagaaca cggtgatgag aacgaggctg atagcaaatc gctcaagggg 3960 gctgaatacg gagtcttcaa gttccttaac atgctcgagc ttgagctgca agcgatgaga 4020 agccctgatg gtagcaaaac atttccagga aagacatgcc gtgacttgaa atcctgtttc 4080 tctgaactca aaaatggtga atattgggtg gatcctaacc tgggctgcgt cgcagatgcc 4140 ttcaaggtct attgtaactt cacaagtggt gaaacttgcc tttatccaaa gaagaccatg 4200 tacgagaaga agaaatgg 4218 <210> 24 <211> 351 <212> DNA <213> Artificial Sequence <220> <223> collagen-like protein 2 <400> 24 ggaatgaaag gacccagagg aagaagaggc ccaaaaggac cgagaggccg aaaaggacag 60 aagggacaga agggaatgaa aggacccaga ggaagaagag gcccaaaagg accgagaggc 120 cgaaaaggac agaagggaca gaagggaatg aaaggaccca gaggaccaag aggcccaaga 180 ggaccgagag gccgaaaggg acagaaggga cagaagggaa ggaagggacc cagaggacca 240 cgcggaccta gaggacgaaa gggacagaaa ggacaaaagg gacagaaagg aagaaaaggc 300 ccacgtggac caaaaggccc aaggggacga aagggacaga aaggacaaaa g 351 <210> 25 <211> 753 <212> DNA <213> Artificial Sequence <220> <223> CREB binding protein <400> 25 atggacagaa ttgaacaaac agaaaaagaa atgaaactaa ctgaaccaat cgaaaatgag 60 aaaagaaaac gtgtcgaatt gatgctggag cgaatgcaac acacagcaag atgcacgagt 120 tcaaattgcg taatgccaag ctgcgcaaag ctgaaacacg tgttgaaaca cagcagacag 180 tgcaaaaaga agtcgaaatc aggatgtcac atgtgcaagc aattcataca cctctgcctt 240 ttgcatgcaa agcaatgtaa atacaacaat tgcttgataa acttttgtag cctcatcaaa 300 cgacgcctac aggagcgaaa gtcaatgctc aacccagcaa ctccaacaca accacaacag 360 cagcaagagc aattacagca gcaggaagag caattacagc agcctcgatt tcagcagcct 420 cgatttcaac atgcatcttc aattggtgta ttgcctggtg tagtgttgcc aagaacagca 480 ctttgcgaca cgagcagaaa ggagagcagg agtggcatta cggatatgaa caggtcattg 540 tcgttgcaaa taccttcaag tgatactagt ctgtggacga gaattcgtcg ctcatcatca 600 ccaacaacaa caacaacagc gtgcaactca acaccagaga tggttggatc gagatacaat 660 ctattgagca aagtcgagga tattgaggca ttgtcattgc tgactaccaa gaagtcagag 720 ttgaacaaag atgaaggtat ggacacttgc taa 753 <210> 26 <211> 1089 <212> DNA <213> Artificial Sequence <220> <223> cubilin (intrinsic factor-cobalamin receptor) <400> 26 gtcactttaa attttaggac ccatcagtca gaaccaaatc gaggatacaa gatcaattac 60 aggatcatac ctccaccttg cggtggaacc ttcacagctc caagtggtgc cattgcatcc 120 cccaacttcc ctcgctacta ccccaacaac cagaactgta cgtacaagat tgttgcccca 180 attggaatgt acgtcaggat caactttaca catttttcca ttgaacgggg cagttactgt 240 cgacaagatt ttcttgtcat caaagaagtg taccaaaatg ccaaaataca aagaacctac 300 tgcggctacg acatgccacc caattacata tctagaggga actcagtgtc aatcaaattc 360 aagagcgatg atgctcgtac aagaaagggc ttcatgctga aatacacatt tttacgcgaa 420 tccccttgca ataaagtctt ctcagcacaa agtggaacct tgacttcgcc aggatatcca 480 aaaaattacc ccatcaacca aaactgcacg aatgttatca aagctgatgt tggaaagatt 540 atagagttga cattcgtgga cttctcgctg ggtggctggt catgtggatg ggaatatttg 600 aaaatcatcg atggatcaaa agtggagaaa tattgcagca acctaattcc cgcaacgttc 660 ttttcaacca ccaactcggt cactttaaat tttaggaccg atgactatgg tacaaatcga 720 ggatacaaga tcaattacaa gatcaccact gacctcgatt gcaatagagt ttttaccgca 780 ccatctggga ccattacatc attgggatat ccaaacagct atccaaacga tagaaattgc 840 aggtatgtaa tcaaagcaaa atctggaaaa gttgtggagt tgaaatttgt ggacttctca 900 cttgaggccc acccaacatg ccgttacgat tatttgaaga tcatcgatgg atccaacatg 960 aaaacttact gtggcagccg acttccacca aagttcgtct caaaaacaaa tttggttgtt 1020 ttgaatttca agactgatgc catacgagta gaaaaaggat ttgagattaa gtacagaatc 1080 gtttcataa 1089 <210> 27 <211> 345 <212> DNA <213> Artificial Sequence <220> <223> cyclic GMP-AMP synthase <400> 27 atggccgact tgaatgaagt attgaacgaa atttaccgaa aggatgtaaa actcgatccc 60 gaacaaacac aacaactcac tggcattttc aacaattttg tggattcttt ttgccagacc 120 atgaaagaag ttgacccgtt gttcaagttg cttttcaaga acaacattta ctacggtggt 180 tcgtattatg atggctcgag aattgtcggc gcaacagagt tctatttaga tattattctt 240 cgcttccctt ttcaaaaaga catcatattt gacacatcaa gcgagcccgg gtatgcattt 300 gttggcctat ctcgcccagt tgaccagctt atccctctga ataac 345 <210> 28 <211> 444 <212> DNA <213> Artificial Sequence <220> <223> cytidine deaminase-like <400> 28 atggcagaag aagcaacaat gacggatagt gaagtgatca taaagagagt aatttctgaa 60 tgtgtgaagg caaaagagaa ttcctattca ccgtacagtg ggttcagagt tggagcagca 120 atcctaacgg atacaggcga aatattcagc gggtgtaatg ttgaaaatgt cagttatggc 180 ctcacgattt gtgctgaaag agtggccatt acaaaagcgg taagtgaagg tcacagaaaa 240 ttcaaagcga tcgctataac ctgcgataat aatgccagat ttctgtatcc atgtggagcg 300 tgtaggcagg tcatggttga gtttcaagct atggaagtgt acttggttac agcggatggc 360 aaagtcaaga aatgttccat ggaagaattg cttccctact cattcagcga tgatgattta 420 aaggcagaaa aacttgacaa ttaa 444 <210> 29 <211> 435 <212> DNA <213> Artificial Sequence <220> <223> DAN domain BMP antagonist family member 5 <400> 29 atggcaatgg taacacgcat ggcattcgca ttgacggctg ccatattatg gggaatgtta 60 atagtgattg cccagcctcg acgcctgcct gagatttcag gcactgatat cgagaacagc 120 cagttctgta acactttgcc attcaagatg actatcagaa aaaaaggctg catgaaaacg 180 acaatatgga acaatgtgtg ttcgggttcg tgcctatccg tctacattcc acagtacaag 240 cgtgccccgt tggagctttg caatctctgt cagcagaaag agcatgctaa tgtcaccatc 300 aagttgctct gcaaaaggtc tggagagcgg gttgaagtcg aagagacagt gtcagtggtg 360 aaatcttgcg gctgcaagtt gcagcgaagc ccgtgtcgtg tctgtgatgc tacaacgatg 420 aattgcgcgc aataa 435 <210> 30 <211> 408 <212> DNA <213> Artificial Sequence <220> <223> deiodinase, iodothyronine, type I <400> 30 atggcaaaga tggaagaatt cagcaaaatt gttgctgagt tttccgacat tgccgatttt 60 gttgttgttt acgtcgagga agctcatccc gtagatgaat ggtgttttaa gaacgcgcaa 120 ttctcgatga aacagcaaag tagactggaa gagagagtcg aagcagccag gtatattgcc 180 acaaaatacc agcacatacc agtttatgcc gatctgatga acaataacgt cagtaaagcg 240 tttggggcac ttccagagcg attgtatatc ttgctcaaca accaggtcgt ctatgctggt 300 ggaataggac cttttgcata tgaccttgag gaaatgcagc actgccttgt ccagtatact 360 gataatctca ataataataa tgataataac aacaataagc tgctataa 408 <210> 31 <211> 825 <212> DNA <213> Artificial Sequence <220> <223> dual specificity phosphatase 12 <400> 31 atgaaaatga tacgaaaagg actgtttata gcagctttag ctgacatcat taatgaaact 60 gaacaacttc ttgctctcag agtcactcaa atcttgaccg tggactctca agaacttccc 120 atcagtttaa agcgcaaatt aatttgtaaa ggagttaaga taaaatacct tcacatgcgt 180 gacgaagcaa gcttcagttt acttgacgct ttggatgaag catttcagaa tttacttgct 240 agaaaaccga cagatataac tgttgttcac tgttttgctg gagtttcaag gagtgcgtcc 300 atcatcattg cttatttaat gaaaactgag gatatttctt ttgatgaagc ttttaaagat 360 gtgcagggca taaaagaaga tatatttcca aaccctggtt ttcaagagca gcttatagtc 420 tttgagaaaa tgggaaaaat tgttgataag actcacccat tgtatagaaa gcatgtcatg 480 gacaaattaa caactaattc agcaccttcc tacaacaatc agcagttgag gcttgaagat 540 gattctccaa atcttccgat ttcaaacgtt aagtgcagga aatgcagagt gacgttatta 600 aagccctcaa atattcgtca ttgtatatct gagcggtgtt cctccatctt tctgaccgaa 660 cccgaggaat ggatgttaaa actggtcgca gatattcccg acgaaggaaa actttattgt 720 ccccattgtc aatcgaagct gggttcattc aactggcaag gtttgttgtc agttaatact 780 tggtcaagac ataaaaaaat gaaaattacc tgtaaattca attga 825 <210> 32 <211> 2679 <212> DNA <213> Artificial Sequence <220> <223> dual specificity protein kinase Ttk-like <400> 32 atgacttctt ccctcgattg gtcgaatgcc cttggctgca tattgacagc tcaggagttt 60 ttgaattccg gtgatcatga agctgtcaaa gatatattaa tgaaattgaa agagaatgga 120 acagagcccg tgattcagag agccctgcat aatttcctga atggaggcag gaagctgctt 180 caaccaataa aatcggccaa gaaaactacg cactccaggt atcaggcagg gacaaaaccc 240 acaccgatca aagccgtacc aaaagagaca acactgttgg gttctacgca atcccaagaa 300 gcaacgtcac tgccaaagca gtatcaatca tcgcaagatg aaaatatttt tggaactttt 360 agcaaagcgc acaataatgc agtgcaagta tctggaacaa cacctttgca gtccatagat 420 aacaaattgt caactgcctt ggacaatgca tgtcagtcga caccagcaaa ccatgtaaca 480 gagcaaagaa gctcttttac agggtctgta aaaccaacac catctcagcc atcggccaca 540 atgccaaagc gatggagaag aaagatgctg aacctgggac caccaagtcg caagatcgca 600 acaccgaaat cagatgctaa gcaaaaagtc gtcatcagaa aacttgaaga atccccgata 660 aactcttcag agcagacctt gccttgtgtt gagagtaata gagtcccaac gttgctgagc 720 aaagctctgt ttccagatgt tcaactgttg gaggggaatg aggctgataa attgcagtct 780 ccttctgaaa tggaagggaa tagcaacaag cgtgatctgt catctcatac aacccctgag 840 acagagacaa ggttgacaga gatgaatcag gatctgtcaa tgggcatgga tctagataaa 900 tacagcttac ataatgggac agggtcatcg tacacactca acactgagta catcagccat 960 acacagagca atgcgttcaa agatattggt gggttgtgtg atgttcttaa caactcatct 1020 aacattctat caagacagaa tatggaatca gcgaagaaga gtgtggatgc tttgaaaaat 1080 cttggatcaa tttctgagga tagtgaacca ggtgttgcac tgttatatgg caataaaaag 1140 agttgctgtt ctgacagtgg tttccaagat gttgtcagca tcggtggaac atccagttat 1200 gattaccaga cacctttgag agccacagtg ctggcccaga aggggaattc cggcaatagt 1260 gtgccatgct tttctaaaga gccagaacct gacaacttca aaataccagt tgaggacgag 1320 attaagaatg ccatcgaaac gagcaaatca gagcaaattg ttaaaccgaa agaacccaac 1380 acgattcttc ttcacaagga cgctttgatg acgtcagatg cacctccgca gtcgtcattc 1440 aaaattcccg cagcgccagt tccgaggatt ccagccaatg cgaaggagga aggaataggt 1500 gcgcagcaac agccatcgtc tggtcttacg gagaagccga gcgtgaacgt gacgccaaat 1560 gccaagagca aagatttgtc agaactcatc atgcaactaa agaactcatc gtccaagcaa 1620 aacaaggggg agtcctccag cacaacgaaa aagaataagt tcgtacgcat caaaagggag 1680 agataccagg tactttcatt gctcggcaaa ggaggatctg gcaaggtcta ccacgtggag 1740 aaggaagacg gccggaattt cgctctgaaa tgcgtgaggc tggaaaggct tgatgacgtc 1800 atactcaagg gatacatcaa cgagatatat gtattacaag cactgtcaga caagccgcac 1860 atcattcacc tttatgaatg ggagtttaaa aacgaagtct tgtacatgct gatggagaaa 1920 ggagacaacg acttgcatca gtttctgcgt tcgaataaaa ccatgtcgaa cgatgagatc 1980 agatcactat ggaaacaaat gctgcttgct gtcaacacga ttcacaaaca gggaatcatc 2040 cacacggacc tcaaaccagc aaatttcatc ttcgttgggt cgacgttgaa gcttattgac 2100 tttggcattg caaaaggaat cgaggataat tgtaccagca cacagcgcgc ctgcctgctt 2160 gggacactga attacatggc acccgaatcg gtctcggctg aggtcaccga cgaaggagca 2220 aagaagaatt tcaagattcg aagagcaact gacatttgga gtcttggatg tatcctgtac 2280 tttatagtgt acagaaaatt gccgtttcag cacattacca acgagcttct taaaatcatg 2340 gaaatcatca atggaaaaga gatcaacttc cctgatatcg acgacaaaga tttgctagac 2400 tcaatcaaag gttgcttgaa aagaaatcca cgtgaacgtt acacaataga acagttactg 2460 gctcacccat ttctgactgg tggtgcacat atttgttcgc aagaagatgg tgagagtaca 2520 gacataccag tgcatagaag tgtagatgag ctcatccata acatcaagga atcgacaatc 2580 aactcgccga attctctact gcgaatcaat aattgtttta tgaagagtaa gacagattcc 2640 cttcaaaata tgcagaaggt cagaaagaca atcttctag 2679 <210> 33 <211> 1539 <212> DNA <213> Artificial Sequence <220> <223> endoglucanase 6 <400> 33 actcctgtga aaacagcaaa gccagaagta acgactcctg caaaaacagc aaagccagaa 60 gtaacaacca atgccgttgt cacaacttca gcaccagaag taacaactgc cccaaagaca 120 aagaaaccat cgacacctaa gcaagagatt acaacttctg ccccaacaac caaacgggcg 180 acaacagcta agaaaccggc taccaccatt gcaagttgcc aatctgaatt tgattacaat 240 caagttttga acctttcact tctcttttac gaagcacaac gatctggtaa gctgcccgca 300 tcgaacagga tcccttacag gggtgattcc gctcttcaag atggcagtga tgttggaaaa 360 gatctttcag gggggtatta cgatgcaggg gacatggtca agtttggttt cccaatggcc 420 ttcaccataa cagccttgtc ttggggtgca atcgagtata aagatgcgta tgtagcatca 480 ggtcaatatc agtacatgct tgatgctatc aaatggggca ctgattattt tatcaaatgc 540 catacggcac caaatgaatt atatggccaa gtcggtgacg gtaatgctga tcatggcttt 600 tggggaagac ctgaagacat gaccatggcc agaccaagtg ctaaaatcga tcaaagcaaa 660 ccaggatccg atcttgcggg agaaaccgcc gccgcactgg cagcggcgtc aattgttttc 720 aaatctgacg cggcctactc gagcgagctg cttttgcacg caaagcagtt gttcgatttt 780 gcagacaaac acagaggtgt ctacagcaac tccattcccg gtgcagctag cttctacaga 840 agttggagtg gctacaacga tgagctcacg tgggccgcag cttggctgta cagggcatcc 900 aacgaagcaa aatatttgac agcagcaaaa tcattctact ctcaatttgg catgaacggg 960 atccccgggg agttctcgtg ggatgacaag aaagctggcg tgcaagttct catggctcag 1020 atcacctcag aaaatacgta caaaacccat gttcaatcat tttgcgattc aattttaacc 1080 aagaagagaa caccagccgg gctggttttc attcaaaaat ggggaccgaa cagacatgca 1140 gccaacgttg ctttcatctg tctcatggcc gctgatctcg gtattaaacc aacgcaatat 1200 cgagcattcg caagacaaca gatttattac atgttgggaa agccgaattc accacgtagt 1260 tttgttgttg gtttcggcaa aaatccccca aaaagacccc accatcgatc aagctcatgc 1320 cccaacaagc ctgaagattg caactgggat gagtacaaca ctgccgcacc aaatccccag 1380 attttgtatg gtgcgctcgt tggcgggcca ggtgaaaatg ataattatgt tgatgaccga 1440 aaggattaca tcaaaaatga agttgcctgt gattataatg ctgggtttca atcggctttg 1500 gctgggctca aacatcttga cttgattgga caatgctaa 1539 <210> 34 <211> 1305 <212> DNA <213> Artificial Sequence <220> <223> ETS domain-containing protein Elk-1 <400> 34 atggatgtta aacaagaaat aaaacatgac agggaagata ttaaacttgg agatggggat 60 acacaagagg caatgatcca aaagaaaata tccttagcca agagggtgct tgagcaattc 120 aagataattg agaagggaag gattggtaaa aaacaagcag gcagtcaaag aaagatgccc 180 ttatggttat ttatgatagt tctactcaag tcagacgaag acgaaatttg cgtgagctgg 240 ctggaaccga cagagtacgt cttcaaagtt ctcaacgcag aagtccttgc tgaaatttgg 300 ggcatgctta aattgaatgc atcaatgaac tatgggaagt taaccagggc attgagatat 360 tattacggaa aaaacctcat cgagaaggtt gctgatcggc cttatactta ttgctttgtg 420 caatctgata agaccaaaga ttacctacct gcacaagcga aggaagaaga aaaatcaaca 480 acagacacac gcttgttaaa tacgaaatca gatgaggtac gcaatgccat aacttatcaa 540 caacggccaa aatcggtgcc tggttgcatc atgcacaatg aacgagggca gcaaagtgaa 600 ctgcgactgg aaaaaagcca agatatggtt tcgtcatttt tcgcaagtgt ttttaggaag 660 tcagagcagc gacagagacc gaatagtgct gtcagtgaca aggatgtaaa cgaagtattg 720 ttgaacaacg tggactatca tgatcgcctc agtcctgtta actttgtcaa ggagaggtac 780 aggacatctt ctttgccatc tcgaattcga tgggtagatc aaccaatgga ggatgtatgt 840 aatggagtgg tggatggctc tggtacatca ttgattctgt cgggtgatga ttgggaagat 900 aagttcctaa cgagacggtc agccaggcaa atgaaggcac cagagacatc ttgtttcact 960 gccaaagact taccgttgtt gaactttgaa gatatcagaa ctcttgaaaa ggatatttgc 1020 tctgatcaat catcaacaac ttgcagctat gcatcgccac gcagcccgaa aagtatcaca 1080 tgtagtgatg tgtatgaagg atgcaacatt gacatggaag aagtggagag gggcttcgag 1140 cataatttga cgagcattac aacaaaccac aatcatttgc attataccaa tcactacccg 1200 aatgtaaaaa cagatgtgta tatggatgtg gattcagaaa tggagctggt cgaggaatat 1260 atcagtgagc atagcagcaa ttcagaaacc aatgtaaaaa gttga 1305 <210> 35 <211> 819 <212> DNA <213> Artificial Sequence <220> <223> FOS like antigen 2 <400> 35 cagagttata aaacaagtga acttaagttt tctaatcatt acaaactggt gactttggaa 60 gactcttgca aaagaagaac aaagcaacag aaaaaattca aacgattatt tatgtcaatg 120 ttgagctttg aggaaattgg tgagcccatt tcgatgtatc aacagagttt taacctgtct 180 gattttatct tggggccttt tgaggaagaa atatcgaaag aaaattttag tgcaatgtta 240 aaaagagagc aagaagatgc tacaaatgaa actcttatgg atgaagacga ttatcagata 300 tcaacactgg acgtggcatc agatacatcg ccaatggaac ccaaggcaca atacaatgcc 360 tacagtggct accaatgtca gcaaacagaa cctacaagcc cgtcaggttt aagcgaatgc 420 tcaagtacat cctcgtcaac gcttggtacc tttcaacctt tgtcttctgt ttacaacggt 480 tgcgctgtaa acagaaattc aatactacct gccaatagta acctttatgc aacgtacgtc 540 acacgcgaac gtggacatcc aggcagaaag cccagactga gagacgaaca gttgcctatc 600 gaggaaagag aaaagcgcag agtaagacgc gaaagaaaca aacttgcagc actgagatgc 660 agaacacgtc gacgagaaag aattgaggta ttagaaaaag agacagacga tcttgagggc 720 gagaacaata aagttcgaag tgacatcagc tgcttgagag cacagttgaa acagttggaa 780 gaaatgctga aggagcacaa ttgtgataaa aacatttga 819 <210> 36 <211> 891 <212> DNA <213> Artificial Sequence <220> <223> gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) <400> 36 atgtcttgca ttgacagtcg accatgcata ggtatattaa cccaagaggt atcaagattg 60 gccataccag aaggaataca aggacactcg tacatagcag catgctatgt gcgacatatg 120 gaagctgcgg aggcagatgt cattccaata ccattagacg caagtgaagc cgatctggag 180 gagcttttct attccatcaa cgctgtatta attcctggcg gcggagcgga tctcaccgac 240 tcgaaattca tgaagaatgt cagatttttg ttagacaaag ctgtgcgagc taataataat 300 ggtgattatt ttccgatttg gggtacttgt cttggattcg aagctttatt ggtcgtgaat 360 ggagaaggca ttgggatatt agacagtgcg gattcattga acgttgcaag accgattgag 420 ttgactgaga gtgggaggga ctcgagaatg ttccgcgatg cctcggcaga gttgatggat 480 gcgtatgaaa agctaccgat tacgtataac aatcattgca agtgtgttac tgtggagaag 540 ttcacaagtt gcagcaagtt ggttgaagag tatcatatta tatcatgtaa cgtcgatagg 600 ataaacaaga agtttgtatc tgcagtggaa gctcgcaatt atccatttta tggcgttcag 660 tggcacccag agaaaatcct ttgggaagac tttcccaact tggccattcc aacgtgccac 720 aattccctgg ccgcatcgaa gtgtcttgct ggattcttcg tgaaggaagc aaagaagaac 780 atgcatcgtt ttgagtcagc tgacaccaaa caagcatgtc tgattcaaaa ttattccact 840 gtttatactg gagacttggg gcggttcaag gaagcttatg tttttacctg a 891 <210> 37 <211> 489 <212> DNA <213> Artificial Sequence <220> <223> ganglioside GM2 activator <400> 37 atgctgaaac ttgtttgtct ttttgcattt gtggcatacg ccagtgctgc ttcgtttaca 60 aattgcaaca acaacttgcc agtgacaatc aacctgagaa gccttccaga tccaatatca 120 attaaagccg gagcaaggat tgcagttaaa gctagcgtta ccgtcagaac gcctgtgcca 180 tccaaaatca agctcagctt gaaggtctac aagaaggtct ggctctggat gaaattgcca 240 tgcgtcaaaa atgtcggtag ttgttcgtac gatgctgatt gcggaatggt gaaacaagtt 300 tgtccgacct gcgattgtcc catgtatcct ggatcaatga atgtggacca agcagttact 360 gtcccatctt caattaatgt cccatctttc ttagcaagcg gaaattacaa agtgaatttt 420 gaagcaagag atccatctaa caataggtta ctggcgtgcg gagagttgaa atttcgtctt 480 tcaaaatga 489 <210> 38 <211> 312 <212> DNA <213> Artificial Sequence <220> <223> GD16675 gene product from transcript GD16675-RA <400> 38 ataaccattg agccaccgga tgtgaagcca actactaaag ttataaccat tgaaccaccg 60 gatgtgaaac caacaactaa agttgtcacc attgaaccac cggaagtgaa accaactact 120 gaagttgtta ccattgaacc accggaaata aaaacgactg ctccaaatac agtacagcct 180 ccattacccg tagtaacaac gaagaaaccc aaaacgatta tgccacccac cgctaggccc 240 gtcacttcac gcagaaggta cgttgctcct tcccgcagaa gatacgtcat cccctcccgc 300 agaagatacg tc 312 <210> 39 <211> 780 <212> DNA <213> Artificial Sequence <220> <223> GJ18296 gene product from transcript GJ18296-RA <400> 39 atgaggagct taagtgtatt aatcgcactt tttgtttttt acataactaa aacagaagga 60 cgtttgaaag gtcgcagatc gttatttgac gatgatcatt ttcaaccctg gtcaacattt 120 gatttgcttt cgagagattt tgaggactcg tttaatgacg atccattctt tgaagatgat 180 gattttgatc cattttttga tgaattgccc atgaaacgtc gaccaacact cgagaagaag 240 gaaggagata aaacaacttc aaagaaagat gcaggacgcg atgtttgcga caagaaatgc 300 aaagacgata aaaaacagct gagctttcct aagctagcct cacgtgttgt tgtaaacaac 360 gacaaagagt ttaaatttgc aatgaatgtg cagggcttcg acaaggggga tatttctgtc 420 aaggttgaga acgatttctt gaaaatctca ggcaaaaaaa cctgcaagaa ggggtcgaaa 480 aagtgcggag agaagagctt cttcagatat cagtatctgc ttccaaaaca tgcggactcg 540 cacaaggtca aggcgagatt ctctaaagat ggttttctga ttgtcgagat gccaaagctg 600 ccagctctgg gggacagacg tgatagcttg caaatcgagg atgaggatga ggaatatttg 660 ccaaaattaa aaagtcaaat ggccagtaaa tccaaacgca aggacggtga aaagaaaaag 720 gatgaaccta aagacaacga aaaaagtcaa gatgaagcaa ccgtggaagt tgtatcataa 780 780 <210> 40 <211> 492 <212> DNA <213> Artificial Sequence <220> <223> gremlin 1, DAN family BMP antagonist <400> 40 atggattcgg ttttcgttct gagcttgata gccttactgt gtttgcaaag aggagttgca 60 tcgtatccaa ctttctttca agaactgata gcctcgaact cgcacggaca agacaacgat 120 ttcgacaacg aagaaagcca cagcaaatac gaagaggttg aaaacgaggc tggtacgact 180 ggacctggaa cgttgatcat gagcgcagat gagtggaaaa tagaatggtg caaggcaaaa 240 gcgttcaatc agactgttcg tcataatgga tgcttcagca aacgcattca gaacaactac 300 tgctatggac aatgcaattc gatatacata cctggacaaa agcatctgga aggttgcaat 360 tcatgtatgc ctaagagcta tcgatggata aaagtgacgc tatattgtcc gtttttggag 420 aagagaagga agcacaagaa agtacaaata atccacacct gtaattgtgt tgaatgtcca 480 aaaaaaactt ga 492 <210> 41 <211> 1788 <212> DNA <213> Artificial Sequence <220> <223> heat shock protein 83 <400> 41 caattcggtg tgggtttcta ctctgcctac ttggttgcag aaaaagtgac agtcatcacg 60 aaacacaatg atgatgaaca gtacatttgg gagtcgtcag ctggaggctc attcactgtc 120 aagagggaca cagaaaacga accactggga cgtggaacta aagtcatctt gcacatgaag 180 gaagatcaag cagattataa cgaagagaag aaaattaaag aagtcgtcaa aaaacacagt 240 cagtttattg gttatccaat caaccttcag gttaacaaaa ccagggacaa ggaaatcagt 300 gatgacgaag cagaagacga ggaggacaag aaggaaggtg agacggaaga aggagaagat 360 gcagagaaac caaaaattga agatgtcgaa gatgaaggag aagacaaaga caaaaagaag 420 aagaagacga tcaaagagaa ttacacggaa atggagcaga tgaacaagac caagccactg 480 tggaccagaa atcctgatga cattacaagt gacgaatatg cagagtttta caagagtttg 540 accaacgatt gggaagacca catggcagtg aagcacttct ctgttgaggg acagttggaa 600 ttccgtgcct tgctctttgt accaaaacgt gcaccatttg atctgtttga gaacaagaag 660 cagaagaata acattaagtt gtacgtgaga agggttttca ttatggagaa ctgcgaagaa 720 ctcatccctg attatctgaa ctttatcaag ggagtggtcg actctgaaga tcttccactg 780 aacatttctc gtgagacact tcaacagagc aagattttga aggtcatcaa gaagaacttg 840 gtgaagaaat gcttagagct tttcaatgag atttccgaag acaaagacaa ctacaagaag 900 ttttacgaac agtttgccaa gaatctgaag ctgggaattc acgaggactc gcagaacaga 960 acaaagcttg ctgatttatt gagatattcg acctcagcat ctggcgatga gttgagctcg 1020 ttcaaagatt acgtctcgag gatgaaagag agccagaagg acatttacta catcactgga 1080 gaaagcaaag agattgtttc aaactccgct tttgttgaga gggtaaagaa gagaggtttt 1140 gaggtaatgt acatgatcga tccaattgat gagtattctg ttcaacagct gaaggaatat 1200 gatggaaaga aactcgtctg tgtgaccaaa gagggactcg aacttccaga agatgaggaa 1260 gaaaaaaaac gtcaagaaga attgaaatca aagtttgaag aactctgcaa ggtgatgaaa 1320 gatatcttgg acaagaaagt tgagaaagtt gtcgtttcca accgattggt tgactcccca 1380 tgttgtattg tcaccagcca gtatggatgg tcagcaaaca tggaacgcat catgaaagcc 1440 caggccctga gagacacaag cacccttggc tacatggctg ccaagaagca tcttgagatc 1500 aacccggacc atccgatcat ggactccttg agacaacgtg ttgaggctga taaacatgac 1560 aaatctgtca aggatcttgt catgctcctc tttgagacat ctcttctctc ctctggcttt 1620 acattggaag atccctttac tcatgcaagc agaatccacc gtatgattcg actcggcctc 1680 ggcattgaag aagatgctac aggagttgct gatgtcagca ctgaagatat gccaacactc 1740 gaagctgaag atgatgcaga ccaacagaaa atggaagaag ttgattaa 1788 <210> 42 <211> 537 <212> DNA <213> Artificial Sequence <220> <223> heat shock protein 90kDa alpha family class A member 1 <400> 42 cttgacgatt tgagcttcag ctgcctaatt tttctctttg gagaattact ctcaaacctt 60 caaggaacga tgtctgacaa gcaaatggat gaagatacag aaaccttcgc cttccaggct 120 gaaattgctc aacttatgag cctcattatc aacactttct actcaaacaa ggaaatcttt 180 ttgagagaat tgatatcaaa ctcttcagat gctttggaca aagtcagata tcaatctttg 240 actgacccaa ccgttttgga cactggcaag gaattgaaaa ttgaaatcat cccaaacaaa 300 gatgagaaaa ttctcatcct gagagacact ggagtgggaa tgacgaaagc cgacttggtc 360 aacaaccttg gaacaatcgc caaatctggc acaaaagcct tcatggaggc cctgaccgct 420 ggtgctgaca tttccatgat cgggcaattc ggtgtgggtt tctactctgc ctacttggtt 480 gcagaaaaag tgacagtcat cacgaaacac aatgatgacg aacagtacat ttgggag 537 <210> 43 <211> 1257 <212> DNA <213> Artificial Sequence <220> <223> heparan sulfate proteoglycan 2 <400> 43 atgaagctct gtctggccat attcctgctc gtctgtgccc ttttcgtctt tgcagatgcc 60 cgtcgtcgta ggtcgcaagt cagagtcaaa ctttcttcca agacgtttta ttatggacaa 120 gacatcggga tatattgcca ggcgaggagg tcgagtttca agttcattgg actcttcaag 180 aaggactccg ctggcaaaga agtgaaaatc aaagctgatg gaaagaaaat caaatccagg 240 cgatacagaa acggcaggtt gatgaaattc tttctcttac cattcacact gcaggaccgc 300 ggtacatata tttgcaagta cgacaaaggc actgcagaaa aacacgtttc acccaaaggg 360 cctgttcccg atgcgcccac ggccaggttc atggccaatg agtatcatgt gaagaaaggt 420 gggcgcgtga cactttactg cgccacaaat ggtccatttg atggatttta ctatggtatg 480 tggagccgtg ttcatctgat ccaagacaag ggaaattaca acgtctttat aagggacaat 540 ggcttgtctg gtaatatcag tcgtcttgtg atccgaaacg taaaggatga tgccaggaac 600 ttttattgcc gctccggaaa ttatctggca tcagctaaag taattgctca caccaacaga 660 aggcgtcggg tcagctttga ggatgaatct ttcgcagcaa acattggttc atatgttcgg 720 ttgatttgca atagcagagg tagcaatgga aacccagagc ttttcaaagt cgacacgaag 780 actggtaaac aagtcaaagt agaaccaacg cacacgggtg ctggtttaat tgctttgtat 840 aaaacagcaa cccctgctga tgccggttat tacctttgta aaaatggagg aggtactgct 900 gttgctactg tcaacgtaga ggtttctttg tcttcactct cgtccggtgg accgattcaa 960 ttgaagaagg gagaaaatgg catcgtgaca attaaacttc caatcgaaaa cgaaagattg 1020 acaggttctg cgcctctcgt gagctggagc aagtctatca agggtacccg caagtacaag 1080 atgattgcca acagatttgg acctatcact gcaaccagtg acaaacgcta cgagtggacc 1140 aaaactggtg ccggcctaat catcaggggt gtaacagacg acgatgctgg catctataaa 1200 atcgtccaca tcaatggagg ttatgagtcg ctatcgtttc aagttgaagt taaatag 1257 <210> 44 <211> 801 <212> DNA <213> Artificial Sequence <220> <223> heterogeneous nuclear ribonucleoprotein K-like <400> 44 atgcagccag ctggcataaa aagagaagct tcttcagaag atcccacggg ggctccacaa 60 gataacccaa agaggtggag gtcagataga atgggttcag atagaatggg ttcacaagat 120 gttaccctca ggtgtcttct acaaagcaag agtgctggtg gtataattgg aaagggtgga 180 cagaacatca aacgactgag aacagagtac agtgcatcag tcaatgttcc agactccaat 240 tcagcagagc gcgttttgtc aatccaagct gtggaaaaga aggccattgc aattctcatc 300 gaatgtctgc cgcaaatggg cccgcctcct tattcgggta ctaaccaagg tccagctcaa 360 gatgaattcg aaataaactt cttgattcat tcaagccaag ccggcagtgt aattggatct 420 ggtggatcaa aaatcaaaga gctaagagag agatccggat gccagattaa gatatactcg 480 gaatgccttc ccaatgccac agaaagagtc gtagcaattg ctggaactga gcaacagata 540 tctagtgcct tggaaaatat cttggaaaca atgtcaaaga ctccaattaa aggaccagtg 600 catctttacg atccatccga tgcgaatgac tacgatgaat ttggtggaat ctacggtggt 660 ggtggtggtg gaccccgagg aatgcgagga ggaatgggtg gtggaatgag aggaggtatg 720 ggtggtcgtg gtggcggtgg acgtggtgga ggcggtggtg gcggtggcat gcgaggtggg 780 cgtggtggtt atagtggtgg t 801 <210> 45 <211> 2121 <212> DNA <213> Artificial Sequence <220> <223> heterogeneous nuclear ribonucleoprotein L-like <400> 45 atggcggacg gaacgactga atctctattt ttgacttttc caacgtatga tcacagcaaa 60 agaataagaa gagacagcca tctatccagc cttaccgtac agaacagttt ctcgtacagc 120 tcaggacttg agctgacaag ccatggagca tatcaccaga actcgctcat ctcaacttcg 180 gataataata ttggcttcat cgatcaacaa ccatccaatg ctgtagattt tgaattaaaa 240 gatgttggga gaagaaattt cgaggccttc tacgactctt taaacacgaa tgggttcagt 300 agcgtgtttg gtttaggcag tggatttcat ggaaatgcaa gatcgattca aaatgcaatc 360 gagaaccaca atatgcctcc ttccaaagtc ttgcattgca gagcagttgc agatgggtgc 420 aaggagactg atattgttgc tgctatgaga cagtttggta aaatcaaagc actgactttg 480 atgcctaaac tacgccaggc ccttgttgag tttgagacgc ctgaagaatc gtctgcttgt 540 atacaatatg ccaagataag tccaatcatg gttcttggtc gacagatgta tgtgaatttt 600 tcgaaaagcc aggagattaa cagggatttc agtagcaata atggcagtct agtggaaaca 660 cccacaaacg ttttattatt cacaattatt aatgcaattc acccaatcaa tgtcgacatc 720 gtcaggaaga tttgctctgc ttacgccgaa gttcagagga ttgtcatatt tcacaaaaat 780 ggccttcaag ctcttgctga atttctatca gccgaggaag cactgactgt cagaaaagca 840 ttgaaccgct gtgatatata cgctggttgc tgcacgctga aaatcgactt ttcaaagact 900 ggtagattaa acgttcatgc aaactcaaat gaaacatatg acattgaaat cgaaaaccgt 960 aagcgatatt atttgacgaa tgacaaggac agcggtctct tctctgaacg cagctcaaca 1020 agcagttact cttcaccctc gtatcaaaac ggtagcctca gttcaacgcc aggccccagt 1080 ccatcattca acaccggaag catgctcaca gattcagttc ttacaaccga cacaaccagt 1140 gcaaaacaac aatttcattt accttcttta tctgacaccg tcgacgttga caatgtcgtg 1200 tcacgaccga caggctatcc acgtgtacaa agcagttctg atctaatcac gaaaacactc 1260 ggaaagcatg cttctagttc aagcaccctt ggctcgttgt tgtctgattc tggtctcaca 1320 aatagcttgg cagaccagca attgtcgcaa agcaaatcaa gcctgcttgc cattcagcaa 1380 aatgccaccg attgctcttc tgcatttgca tcctatggca gaagtctcag tttagctgga 1440 ggtgaaggct gtgtggccat ggtttacgga gtcaacaccg agcgaatgaa ctgcgatcgt 1500 ctatttaact tattctgttt atatggcaat gttgtcaagg tgaaagtctt gaccaacaag 1560 ctaggagcag ccatgatcca atacaccgat aaaatgtcca ccgatattgc catcaggaac 1620 ctcaacaatc tcactttatt tgcaaacaaa ttccaactgt cattttcaaa acacccattc 1680 atagcagatg cctcacagat ttctcgtctc cccgacagta caccctctgc tgctaatttt 1740 gcagactcca gaaataatcg attcaaatac attcctggag gagtagacat attttcacgc 1800 attcatcctc cttcaaaagt tttgcactac ttcaatgccc cagccgattg caccgaagag 1860 cagctcagcg aggtattcaa cgcagttgga gcagaaatcc ctctcaaaca ggcaacattc 1920 tcaaaagcat cacgtgttat tgacccaata ttaaccacag ctggacaagt taagtcctct 1980 tctggcctgc ttgagttcag cactgtacct acggctgttg aggcattaat ccttgctaat 2040 catttcacta tgcacagaga aggtggagga gcatttacat taaaacttgc tttttctccg 2100 agtagcacga tcaacagttg a 2121 <210> 46 <211> 2553 <212> DNA <213> Artificial Sequence <220> <223> hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) <400> 46 cccggaatga aggaaaggaa agattgcaga tggagatgga ggaaacacaa agtgattgaa 60 cgaaacctca gttccatcac caacatgtct tacattatta ttgtttttca gatagcctgt 120 tttatcctgc taccatgctc acttgatgct acagtttttg aagaggcttc gcctgggcct 180 agtttcagtg caaaccaaac gcaaacaacg ataatattgt tcggatcgac aggggactta 240 gcaagtcgtt atttatggcc tgggttttac aagttatatc tttcaaagat cggaggcaac 300 acaggtgatc tacttcgaat atatgccact ggcagaaggg atgaagaaca tggaagacaa 360 gctttgaata gtttgttgtc gtcagaaaag ctttgccaga cgaaggcttc aatatctaat 420 gacgagattg ataactgcaa gggaagtatt actgggtttt caaaattatt ctcttactac 480 agaaccaaga cagaagagga ttatgtgaca ttgtcgaaaa taattaatag tgaattgcag 540 caaactcaga tcagagaaaa ggcgagaatt tactatttat ccgttcctcc ctttgcttac 600 gaaggaattg ttaaatttat aaacatgtac ttacgaccaa tggattcatt caacacgaag 660 ataaggattg tgcttgaaaa accgtttggt catgaccaga agtctgccaa aagtctagga 720 gaagaaatat tgaaatattt caaagaggag caaatctaca gagttgatca ttatttgggt 780 aaacagacag ttgatgaggt gctgaaattt agagccaaca attacaacat gcttcacaga 840 atttggaaca atcaatttat tgagagtgta gaagtagtta tgaaagaaac tgttgactgt 900 aaaggaagaa cagagtttta caataaatat ggagttgttt tggatgtaat gcagaaccat 960 ctaactgagg tattagctag agtattaatg ccccatccga tgcaacatcc tagtcaacca 1020 tttgagcagt taaagttgca aacattgcaa agcattttct cacccgtacc cggtatggct 1080 gttgcgggac agtataagaa ctatacacgt catgttatgg aagatagaag ggccgaggct 1140 ctcgacaaca gctccacagc tacttatgca gtagttgttt tgcatacagg ccaaaatgat 1200 tgggaaaatg ttccattgtt catggtgagt ggaaaacagc tgaatgaaaa atctacctat 1260 gttaaagtta attttaaaac tccatatata ttaaattcat ctgcttctga agacattgac 1320 aacaatgaca acgaaaaagc atttataaag ttctacatcc acagctcaaa gtatgatgga 1380 ccagcagttg aaattcaaaa ttggcaagat tctttaaaac ttgaattttc atcatattgg 1440 gataagacta ctgcaaagaa taatttaata gttctaaagc caaagaaagt gatagatgct 1500 tataccacgc taattgagaa gatttatgat ggtgataggt cgtattttgt tcaattggac 1560 tcgctacttg aagcatggag gatttgggat ccgcttcagt ctgctataca atcaggagag 1620 ttgggattaa ttaagtacga catgaaaagc aatccatttc ctaacatcta ctacgatcct 1680 attgctggaa aattgcattg gaagcagaca gatggggaaa tatctcatca ggatgatagg 1740 gaaatatctt ataatgatga tagtgattat gatccttatt atgtgagatc cacgcaacaa 1800 ttttcatcca tcacacatga aacatttctt ggcagtaaat tagtaagagg gaccattgaa 1860 tatttgacga ataacatgtt tgacgaattt atgaaagaaa ttaccgaaac agttcgagag 1920 aatgattttt accacgttgc attaccagga ggtagcagca ttaagccaat gcttgcgaaa 1980 ttatgcaaag gtaaacataa gattgatgcg aagtatctgc atgtttggat tgtggacgaa 2040 agatgcgttc ctttgaatca cacgctttca aacttcaagc tcattcatga taatctatta 2100 agctgccttc agctgcctta ttttaacatt cacccaattc gagtggacgt aacttgtcaa 2160 catgacagcc ttcaagcgta cgaagaaaac ataaaatcat ggataccttc gatgaaattt 2220 gatatgataa tcctcggact gggagccgat ggacatgttg cctcgctgtt tccttgggac 2280 cacgcagctc ttaattctac agaagcaata attgttactg acaaaggacc aaaaaataat 2340 gtcccgagaa gggtgtcaat gtcgtttcat ttgatcaaca gtgcaagaaa agtgatcgtg 2400 atagctgcag gtgagaagaa aaagaatatt atcgagaaat taaaaactgc tggatacaca 2460 agcaacgagg aggtaccagt cttgctgctt agaagagatt ttaaatcagt aacttggtat 2520 atagatgaag ttgcgtttgg aaatgagaaa taa 2553 <210> 47 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> hornerin-like <400> 47 gtaccaccag taagatatcc agttcccgct gctgatcgtt atgctctcgg tgctggacac 60 atatggcctt cttccaacta tggtttacaa tatggtgggc cttatgcttg gagcagatct 120 aaaacgccgt ctaaagcaaa gacggacgct tctaacaaac gacaaatcac tccggcctac 180 actcccgttg tatcagagcc agtgggtgtg ccaccaatca gatatccagt gccagcagcc 240 gatcgctacg ctttaggagc aggtcacatt tggccctctt ctaactatgg cctacagtac 300 ggcggcccat atgcatggag c 321 <210> 48 <211> 471 <212> DNA <213> Artificial Sequence <220> <223> kinesin-like protein KIF23 <400> 48 atgcacaagc ccgtgggaac actcaacaca gacacagtta tgcaaccagt tgttagaaac 60 aaaaagaccg tcattgtacc aaagattggc gatttaaagg acccaatcaa ctacatgcta 120 acacaccaag aagaagactc tgccggagag atcgaaacaa aactttacaa gggtcaagtg 180 atgaagacca gaacaggggg tcacagcgtt caattcactg acgtagaaat gctcaaacat 240 cgatatgaag ctgctgccgc caacgcctca gctacccccg gaaaagacac ggaatccagt 300 ggaagtgatg tgcagggacg gggacgaaaa cgactttctt gtgaaacaga agaggagcag 360 acagacgaaa gtgttacaga tgttgaaaca agatgtgcag ctggcattgg cggaggcccg 420 cgtgcagaac acagtaattt gctaactcaa gcaaagcgaa gaaagccttg a 471 <210> 49 <211> 528 <212> DNA <213> Artificial Sequence <220> <223> leptin receptor gene-related protein-like <400> 49 atgggtatca ttcttgcgat tctctgtgtc tcacttcttg ctgcggtagg aatactcctt 60 atggttgcta gctgtgcttt gaaacagatg caaacaccaa agggagcttg ttggattctt 120 tgtgttttgt ttttctattt tattatgcca ctctgcatgg ttttcatcaa aaaagtttca 180 aaagttcttc gttctttttt gagagaggga gaattacaag cgtgggcaca gcaaaacaag 240 tcaatggttt tgaaaatcag gcttatattt gattttgttc tatttggtac aactggaata 300 gtgttgtctg catttgccct ccctcttgtc cttgccagag caaacgttat caaatgggaa 360 gctgtgggga taatatctgt tgcacatttc ttcatttttg gcagcatgtt tgcattttat 420 aaacaatctg tccgtcataa acacgaagct gaagaaaagc atcagtataa tttaaattct 480 tgtaaaaata ccagagctgt aatgacatct ttgataaaac atcaataa 528 <210> 50 <211> 1515 <212> DNA <213> Artificial Sequence <220> <223> leukotriene-B4 omega-hydroxylase 3-like-1 <400> 50 atgacggtta taactgattt attgtgcaga tgggagctgt atattgcaat tgtgtgcgtg 60 tttttcattt cacgtatcgt acaatggtgg ctcaaccctc tgcgaaaatt acctggacca 120 acaggcctac caatattggg taataccctc gatttctcac agagcaatga tgtacatcaa 180 atgttactga agagagcgaa aaaatacggg cctatatata aaacctattc tctttttgtt 240 ggtactcgcg tgaacatttc tgatccagca tttgctaagc gcattcttgt cacaaacagc 300 tccaattatt acaaaaatga tgggctgcga agttttctgc cagctatggg aaatggattg 360 ctgacaagta gtggcaggga gcatgcgcag caaaggaagc atcttaaccc ggcgttttca 420 atggaaagcg tcaaaggatt tatttcagtt ttcagtgaca agggaaacga actcgtaaag 480 ttttgggaca caaagatcaa tgaaagtggt ggcaaatcag tggaatcaga gatgatgacg 540 aaattcatac atctcacatt ggacgtgatt ggtctgtgtg gctttgggta cgcattcaat 600 tgcatcatgg gagagaatag cgaggagagc aaggcgacga acacgatttt gaccggacaa 660 ttcaacgtgc gccaaagact gttggagacg tttttgcctt ttttgaagct attcccatcg 720 aaagaaagag accgcgtaaa gaaggcagaa acgattctct atggcttaat tgaacatatc 780 attgccacaa ggcgagacga aatgaaaacc tcatctgatc agacctcacc gaaaagagat 840 ttgttgcaaa aaattctcaa cctatacgag gctgcaggtg aagaaatatc aaacaaagga 900 gtattccacc aaatgttcac atttctattg gctggacacg aaactaccag cctctctctg 960 acgtggacaa tgttccttct ggctaagaat ccgcactttc aggaccgggc ccgaaaagag 1020 atcaaagagg tcctcggtga caagtcgcac gtatcgtttg aagatctgga caaattgaag 1080 ttccttgatg attgcattaa ggaatcaatg cgattgtatc cagtagcgat tatgccttcc 1140 agaaagtcat taaaagaaga caagttcggg ccatatacca ttccagctaa cactaatttt 1200 ggtattatgg ttggagttct gaatcggaac gaaaaaatct ggaaagatcc cgatgacttt 1260 aatccggaca gatttgcttc gaacaaaggt gaaggtgatc cactgtttcc atattatttt 1320 cttccctttt ctcgtggtcc gcacatgtgc attggctaca gatttgcgca gatggaaata 1380 aaagtcgtcc tggcgcaact tttgaattca ttctcattcc gacttggaaa gaaccagcca 1440 gaacacgtga gaggaaaaca agttcttaca ttgaaccccg aacctgcccc tgtcatcgag 1500 ataagcagag cataa 1515 <210> 51 <211> 1515 <212> DNA <213> Artificial Sequence <220> <223> leukotriene-B4 omega-hydroxylase 3-like-2 <400> 51 atgacggtta taactgattt attgtgcaga tgggagctgt atattgcaat tgtgtgcgtg 60 tttttcattt cacgtatcgt acaatggtgg ctcaaccctc tgcgaaaatt acctggacca 120 acaggcctac caatattggg taatactctc gattactcac agagcaatga tgtacatcaa 180 atgttactgg aaagagcgaa aaaatatgga cccattttca aagactatat tgtttttgtt 240 ggtacccgca tcaacatttc tgatccagca tttgctaagc gcattcttgt cacaaacagc 300 tcgaattatt acagaaatga tacccttacg aaatttctgc cagctctggg acatggattg 360 ctgacaagta atggcaggga gcatgcgcag caaaggaagc atcttaaccc ggctttttca 420 ttggaaagtg tcaaaggatt tatttcagtt ttcagtgaca agggaaacga actcgtaaag 480 ttttgggaca caaagatcaa tgaaagtggt ggcaaatcag tggaatcaga gatgatgacg 540 aaattcatac atctcacatt ggacgtgatt ggtctgtgtg gctttgggta cgcattcaat 600 tgcatcatgg gagagaatag cgaggagagc aaggcgacga acacgatttt gaccggccaa 660 ttgaacgtgc gccaaagaac gttggagacg tttctgcctt ttctgaagct attcccatcg 720 aaagaaagag accgcgtaaa gaaggcagaa acgattctct atggcttaat tgaacgaatc 780 attgccacaa gacgagacga aatgaaaacc tcatctgatc agacctcacc gaaaagagat 840 ctgctgcaaa aaattctcaa cctatacgag gctgcaggtg aagaaatatc aaacaaagga 900 gtattccacc aaatgttcac atttctgttg gctggacacg aaactacgag cctctctctg 960 acgtggacaa tattccttct ggctaagaat cctcacttcc aggaccgggc ccgaaaagag 1020 atcaaagagg tcctcggtga caagtcgcac gtatcgtttg aagatctgga caaattgaag 1080 ttccttgatg attgcatcaa ggaggcaatg cgattgtatc cagttgcgat tttcactgcc 1140 agaaggtcat tgaaagaaga caaattcgga ccatatacaa ttccggccga cactattctc 1200 attgttttga ttggggctct gaatcggaat gaaaaggtgt ggaaaaatgc caatgaatac 1260 aatccagaca gatttgctac aaaccaaggt gaaggtgatc cactctttcc atattatttc 1320 ctgccctttt ctcgcggtcc acgcatgtgc attggctaca gatttgcgca gatggaaatg 1380 aaagtcgtca tggcgcagct tttgaattca ttctcattcc gacttggaaa gaaccagcca 1440 gaacacgtga gaggaaaaca agttcttaca ttgaaccccg aacctgcccc tgtcatcgag 1500 ataagcagag cataa 1515 <210> 52 <211> 1725 <212> DNA <213> Artificial Sequence <220> <223> low density lipoprotein receptor-related protein 2 <400> 52 tcaaatggcg aatgcatcat gagtcaatgg ctctgcgatg gagacattga ctgtgcagac 60 gaatccgatg agaaatcgtg tactccaaaa ggctgtcgtt ccagcgagtt taaatgtgct 120 gatggtaaaa ggtgcattcc gctgaaatgg ctctgcgatg gagccaatga ttgtgaagac 180 aagtcggacg aattcaactg cagtagcaat tttacaacaa cagtaacaac aaatgctact 240 acttccattg ctacaactgt ttctccactg tgcccaccga acttcttcag atgcaacaat 300 tctcagtgtg tatcagtcaa tatgacttgc gataagacag acgattgtgg cgatgcaagc 360 gatgaagaaa attgcacata ctgtagtgtc ggtcaatttg aatgctcaaa tggagaatgc 420 atcatgaatg aatgggtttg cgatggagac gatgattgtg gagataacag cgacgagatc 480 aaaagttgtg gcaccaccaa atgcagcaca gcagaatttc attgtccaac tgacaacaga 540 tgcatcccgc ggatttggcg atgcgatgga gacatcgatt gcgacgataa aagcgacgaa 600 cagcactgcg acaaaccaag cccaaccaaa ccgcctgcta atgtcaagtg tgcagctaat 660 ttctggcgct gtgcaaacag gcattgcatc gtgaagacgt ggttgtgcga cggagaaaac 720 gactgtgacg atgggtccga tgaacgcaat tgtgaactcc ggttgtttgt gtccaatcga 780 ttcgacatca gaagcttcga cccgaacagc gggtcaaact cccgaatggt gttgaagggc 840 ggaaagggta ttgtatcgat cgactttgac atcgcaaacc gtcgattgta ttggacggat 900 accagagaag gcactatcaa acgtatgacg ctcaacgaaa gcacaaacag tgtcgacgac 960 tcctggcgct caacaacaaa ccacgaagta ttggtacaag gattagacaa tcctgaaggc 1020 ttaaccgtgg actggcttgg aaggaaactg tactgggtcg atggaaggtc ctctgttatt 1080 ggcgttgctg agcttaatgg atcgaataac atgacattga ttaggttggc caaaagagat 1140 cggcccaggg ccattgtctg tgaccctaaa cgtgggtatc tctactggac caattgggga 1200 cataatgcgt caatcgaaag aatcgctatg gatggagatg cgaagagtag acagaaactc 1260 gtcaccacca atatcggctg gccgaacggg ttgaccttgg atagctcacg ccgcaaaatg 1320 tactgggtag acgccaagct taagcgattg gaggttgctg accttgacgg taggaacaga 1380 cagttgcttg ccggtccgga tgacatctac cacccctttt ccctgactga ctacggagat 1440 tatctgtact ggagcgactg gaggttgcga ggaattgtca aggctcataa gtatcaacgt 1500 cccttcaaaa cgactaaaat tgttggtttg cctttgacgt cttttggagt gaaaatcttt 1560 cacccgtccc tacagcctgg cggtttcaat ccatgtgcat ttaaaaatgg cggatgcagt 1620 cacctgtgtt tgcttacaac aattcgtcgc ttttcgtgca agtgtccgct tggaatggac 1680 ctgaaacgtg acctgaaaac ctgcaccact tcaaattccg tgtga 1725 <210> 53 <211> 1065 <212> DNA <213> Artificial Sequence <220> <223> mab-21 like 2 <400> 53 atggcattca caagcaacaa aatgcagcaa gatgtcgccg agtttatttc aaccagagta 60 gaaggaagaa aacaagaaac atccaagaat attgagattg ttttggaagt tcttaaggag 120 attttctcaa aattaacaat tcacgagccg agatttcatc acaaatgcca atttgacggc 180 gaaagggttc tggggatgca ggccattaca ccaaaccaca tcgaatttcg catatacctc 240 gatcagatcg agatgttcag agtaagcgag aacggagcac cagacggagc aacgtttcta 300 gatctcaaag acgaagtcag aaaagattgc tgcatatgga gcgagtttct cacagctgcc 360 gggcacttat cagcaagaaa agtcagagag aaatttcagc tgattctaca ccaagcattg 420 aacagaatca cgtggatgcc agagaaacta tacgtcacac aacagaaagc cagtcctcgt 480 ctgtacataa acgaggacat cattcttgac atatacccaa gctttcgatg cacgagacaa 540 tggccgatgg atgtcaagat tcgatctgtt ccagcgacga caagaaaaca gcacgcgaat 600 gaaccatttg agttcgagtt ggtggcaatg gaggtaggta gctcacagcc ttactcaacc 660 gacagagatg catggaagat agatttctct acgtcagaaa acagactgat cggcaaaggc 720 aaccgtcggt tgtgtctgag tattttgaaa acagtttcaa acagaaactg gcaagaattt 780 tccactgtca tctcaccata tgctctgcag acagtgttta tgtacgtctg cgaaaagcat 840 gtaaaagagg agttttggaa tacaaataaa ttgcccgaac gcatcaatgc ggtgttatta 900 cagttggttg cttgtctgca aagtcgatgt ttgccgcatt actaccttaa aggcatcaac 960 ctcttagagg gaaaaagctc acgaagtatc aaagctgccg tcgaagagat gtggaaatat 1020 gcaagggagc tttgcaccaa taaagacttt ttcagtgtca tttga 1065 <210> 54 <211> 618 <212> DNA <213> Artificial Sequence <220> <223> metalloproteinase <400> 54 tcagaagtct tgtcaggaaa cagtgacggc aaagatggcg gagagaaact cgtctcagaa 60 atatgcggac ttgacatgat tccagaagtg acagaaaagc agttggaaga ggaggagcca 120 aacgaaaaaa ctgacaaggc agatacacca gatgatagta ttctcgaaca tggtgacatc 180 cttatgacaa aagaacaagc aaagacgttt aaagagaatg aaaagcagaa acgcgcggtt 240 atcaaacatt cgccagcttc ccacaatttc cgttggaata cgaagacaat cccattccac 300 ttggatgcct cacttacaga tcaatcaaaa aaggcgataa agaacgctca tgacgtattt 360 aaaaaatata catgcatcga ctttaacgaa gtagacgcaa acagtcaaac atttcacatc 420 cgatacaaga aagccctcgg ctctaaatct tatgttggta aacaagatga aaacataaac 480 aatgcagatt atctacaaaa acataatgga cagcgaaaat acttccaaga aatatattta 540 caaggatata ccaggatatc aacagttttg catgaaacaa tgcatgcgtt tggcttcgtt 600 catgaacaag aaagaccg 618 <210> 55 <211> 306 <212> DNA <213> Artificial Sequence <220> <223> mucin-4-like <400> 55 gaggctccta caacgaaaga agaacccaca actcttccag caacgacgaa ggaagtcact 60 gaggctccta agacgaaaga agaaccaaca actcttccag cgacaacgaa agaggtcacg 120 gaggctcctg caataaaaga aaagccaaca actcttccag cgacagcgaa agaaatcaca 180 gaggctccta caacaagaga agaacctctt ccagtaacga caagggaagt tacaagggct 240 cccacaacca aggaagaatc aacaactctt ccagcgatga cgaaagaagt cacagaggct 300 cctaca 306 <210> 56 <211> 549 <212> DNA <213> Artificial Sequence <220> <223> muscle-specific protein 20-like-1 <400> 56 atgtctgcaa gaccaactgg ttatggactc acggcggaga caaaaaataa aatcagctca 60 aaatattctc cagatgccga acaacaagct ttaatttgga ttgaagaagt tctagaagac 120 aatgttttcg atggagccac gggtcaaaaa caaattcaac tggccttgaa agatggcagg 180 atattatgca gactgataaa cgcactgaat ccttccaagc cggtgaaatt caacaacaaa 240 gacaagctaa tgccgttcaa aatgatggag aatatcggcc agtttttaca aggctgtgag 300 gtatatggtt gcaaggctgc ggatttgttc caaacagcag atttgtacga caatcagaat 360 atgcatcaag tcatacttgc tgtacacgcc cttggacgca gggctcaagt tatggggtac 420 actggtccta cgcttggtcc aaaggaatcg ctcaagaacg aaagagtgtt cacagaagaa 480 caactcaaag cagggcaagg cgtcattggc cttcagatgg gctcaaacca aggggccaat 540 gcatctggt 549 <210> 57 <211> 543 <212> DNA <213> Artificial Sequence <220> <223> muscle-specific protein 20-like-2 <400> 57 gcaagaccaa ctggttatgg actcacggcg gagacaaaaa ataaaatcaa ctcaaaatat 60 tcttcagacg ccgaacaaga agctgtaact tggatcgaac atgttctaga agacaatgtt 120 tttaacggag ccacgggtca aaaacaagtt caactggcct tgaaagatgg caggatatta 180 tgcagactga taaacgcact gaatccttcc aagccggtga aattcaacaa caaagacaag 240 ctaatgccgt tcaaaatgat ggagaatatc ggccagtttt tacaaggctg cgaggtatat 300 ggttgcaagg ctgcagattt gttccaaaca gcagatttgt acgacaatca gaatatgcat 360 caagtcatac ttgctgtaca cgcccttgga cgcagggctc aagtaatggg gtatactggt 420 cctatgcttg gtccaaagga atcgctcaag aacgaaagag tgttcacaga agaacaactc 480 aaagcagggc aaggcgtcat tggccttcag atgggctcaa accaaggggc caatgcatct 540 ggt 543 <210> 58 <211> 456 <212> DNA <213> Artificial Sequence <220> <223> neo-calmodulin-like <400> 58 atgggtagca aaaagttatc agaggaacag atcaaggagt tccgcgaagc ctttctggtt 60 ttcgacagag atggagatgg gacggtaacg gtgtcagaaa ttggtttggt catgaaaagt 120 ttaggacaga atccaacaga agcagaaatc aaaagcatgg ttcaagaagt cgacacgaaa 180 ggccagggcg aaatagattt cgacgatttt tgtgtgctca tgcagcgcat gtccggtgat 240 ggtggcgaag acacgtacga tgaaacgaag gagacattta aggtctttga caaccaggcc 300 aatgacaaag tcagagtgtc cgatttgaag aaagtcctcg agagtctcag cataaagctg 360 acgtcatcag agttgagcgg agtactggaa gaaatgggat cagttggctc tgaattgaat 420 tactcagact tcttgaaaat tttccagttt gaataa 456 <210> 59 <211> 1359 <212> DNA <213> Artificial Sequence <220> <223> netrin receptor UNC5C-like <400> 59 cgagataccg gcttttcttc actgttggat aacagtgaca caatcatttt ggagacgcgt 60 gcaaagattg gaccgcgcgg agggcagtta aaggttgaag gctcatctgt tgttgtcaat 120 gttcctacag gtgctataat cggaaaggag caagaaatgt cccttaaggt ctacctcggg 180 cgaccaaacg attatcaaga gctggagaga cttgggcata ctgttgaact tccccttgtg 240 gagctgggac cgagtgggtt gcgattcaac cggccggtcg aagtggtcac acagaacagc 300 tcggtcgacc cagacgatgc cgatgatgaa gatgacggaa tcgactttga atatgctgat 360 ggcatgttca agccagacac tgtgtggaag aaggccctac gggggagcac cagagaagaa 420 tccatagcgt tggccgttga aaaagaaccc catgtgagct tctttgtaac cagtgcccaa 480 acctgcgcat actacatgca tttcacactg ggccgtaaat tacttaaaag atcgtcgagg 540 aaaaatctag cggcgtgtgt gtatgcagac ggcaaacatg ttcaggtcag cggttgtctc 600 cgactgggca tcttctttta tgagaattca gaggaaggag aaacgatttt gcaaaggaat 660 acaagtggta tggaaaaggt tgcacttcca aagccgttct ctgtgcgaaa gggagcttct 720 acgagagtgc aaatgcagaa cttaactgat ggctggagcc tgaagcaagg acacaacgag 780 caggaggttt ctcttgaaag tttctttcaa gcgtcgaagc ttgggaaact ggcgtcaagt 840 gattacataa ttgaaaacga agagaatccc agctctctct ttacatgttt gttcgatctg 900 caccaagata acaacaaact ggccgatttg aaagtcatgg gacgtataat tggaaggcaa 960 tactccgttt catctggtta caattctgat gcgtcgtctt ttcaagcaga ggaggaatcg 1020 taccacatca cagaaccaga tgttcccaag actgatcctc gtaaatatat gaataggata 1080 attcatcaat tatccccact cgttactccg aagtacaaat cattctgcag aaggctggga 1140 atttcggaga ttgcaatcga cacagccgaa atggaccgtg gtcgcgaagg atgctatgaa 1200 gtctgctgcc aacttctgct gcaatggctt cgcaatcacg atgacggggg acatttgata 1260 gagactgcaa tgagtgagct caaatcagct gtggatagaa ccaagcttca gtgtacgatt 1320 cattttccaa gagttaaagc gagagagacc atagtttaa 1359 <210> 60 <211> 1647 <212> DNA <213> Artificial Sequence <220> <223> nicotinate phosphoribosyltransferase <400> 60 atggcttcaa catacgccag tgaacctcag aatggaattg tcaaaccttt gcttaccgat 60 ctttatcaaa tatctatggc ctattcgtat tgggaaagcg gaaaaacaga tgaaactgcc 120 gtctttgatc tgttcttcag gacaagccca tttcaaggag agttcacgat atttgctggt 180 ttgcacgaat gtcttaattt cttgaatgcc ttcaaattta ctgaatcaga tgttgaatac 240 cttaaaacag tcttgcccag ctcatgccaa gaagggtttt ttgactacct tctcaatcta 300 acaaccaagg acatcaagtt gtatgcaatc ccagagggaa ccgttgtatt tccacgtgtt 360 ccattgcttc gagtggaagg acccctccca gtcgctcaac ttttggaaag tacatttttg 420 aatcttgtca actatgcaag tttggtggca acaaatgcag ccagattcag aattgcagtt 480 ggtgatgaaa agaaactact tgaattcgga ttgagacgag cacagggacc cgatggagcc 540 ttgtcggcat caaaatattg ctacattgga ggttttgacg gatcgagcaa tgttttggct 600 gggaagaaat ttggcattcc ttgcaagggc acccaggcgc atgcgtacgt gacttctttt 660 ctcgagactg acgaatacag agtcgggaca ctggaatcta aggatggatc gatttgttcc 720 tataaggctg accaatttta cagctgtgcc aaagcgaaac ttagcgaact agcacccatt 780 ctaaatgtgc cgctcgacca agttaatgtc agtgaattga tttcgtttgc cacatttgcc 840 gttgcttttc caactaattt cctggcatta atcgatacct ataatgttat aaggagcggc 900 ctaccaaact tttgcgcagt tgcattggct ctgaatgagt ttggttaccg tgcgattggt 960 gtaagattag actcgggtga tttggcctat ctgtctaaaa ctgttcgaaa gaatttcgcc 1020 actgttggaa aacattctgg cttggattgg tttgaaaagt tagttattgt tgccagcaat 1080 gatttgaacg aggaaaccat ttattctctg gctcagcaag gtcacgagat agacatcttt 1140 gcaattggaa ctcatcttgt gacttgccaa aagcagccag ccttaggatg cgtcttcaag 1200 ctggcgtcaa taaataagca tccaaaaatg aagattagcg aagaggtgaa aaaggtgacc 1260 attcctggta aaaaatccgt ctaccggctt tacggagaag atggcaaagc attggttgat 1320 ttgatgcaac aggcagacga accccaacca atcgccggcg accgaatcat gtgcaggaat 1380 ccgtttctcg atttaaaacg tgcgcacgtc cacccatctc gcgttgatca attactgcaa 1440 tgttacttca gtgacaaaaa gattgtgaaa aagttgcctt cgttgcaaga agtaaaaaag 1500 tatgtgcagg agtctttggc cttgattcga gacgaccacc ttaggcctct gaatccaaca 1560 ccatacaagg tctctgtatc ggaagagctg tacaaattca tgagtaagct ctggttgaat 1620 aattctccaa tcctcgaatt gtcataa 1647 <210> 61 <211> 1587 <212> DNA <213> Artificial Sequence <220> <223> nuclear factor, erythroid derived 2,-like 1 <400> 61 atgaatttta aatttgtcac aggccttttg aatatcgctg tagcactatc attatttgat 60 tggaagaaca acaatgaaca agaactgcaa agttttggca ctttccttcc tccagtcaat 120 gttttgcaag gacagactgg aagagatagc caccgcatgt caaacttgcg tccttcaaaa 180 gaaaatgaaa gcgtaatcga tagcattatc aactgggaag aaagccagag atcgaataga 240 tacaacagag acaacgtaag cctagttgcg tatccaattc tctcgcaaca aaactctcca 300 tttcatcatg attttgatac tcaaagcagt ggtgcatcgt tgaatttacg acccaacttg 360 gaagtagcca atcttccaac ttcaattgaa gaaccagtta gccctggtga tgcatggata 420 ccttcatctc cgagctcatc atttgaagat ggagaattat ttggtgccgt gggctacacg 480 cctcaagaca gcacggacta ttttgacatt gagagtttct tgaacaacgt cagctttcca 540 tctccaagta gtagcagttt atcgtcgtca gcgtcttttg aagatgctgc aaatggcgga 600 gtatttccac cgccgaattg gattaatggt tcgccttcag aatctctcga agaactagca 660 gaattcttgc aagcttcaat tgcaagtcca gaatctggtg gttctcccga tttcatgcaa 720 gaggagagct tctctccgcc agtacccaat caaagtagct accaaaattt catgcaggaa 780 agtttgcatg agttgtacaa ggaaagcaag caaggacttg catcagcatt ttctgacatt 840 gcatttgaag aagataaaaa aatgtcaaat attgaggctg tttttggtga cgagtttcat 900 catacaagtt cttccaaagg aaaaggtacc caatttgcag atattgaaag ctacagggat 960 gcaaagaaga aagagccgat attgatttca aagaataaag tcaaaaagga aattgcttct 1020 ccattcagag atgacgaatt taactgggaa aaaagctgca gtacttcttc acttgacagt 1080 ggcagttcaa ctgattttca gaaggagggt agaaaagagt tgttgcagga ccataaaatg 1140 gactacaagc gaatttggaa tgatcttcca tatacgaaaa aagatcttgt agtaatggac 1200 attgatgagt tcaacaatct tattgcaagt ttagagccac tccagcaaca tgttggtaga 1260 gacatcaggc gaagaggaaa gaacaaactg gctgcaagaa gctgtagaaa aagaaaattt 1320 gaagctgtgg attcattggg gaaagttgta gacgagacag aaagaaagaa agaagaactt 1380 ttaagtgaga aattgatgct agaagaagag atggcagaga taaagcgaaa aactgctttt 1440 ctctatgaac acattttcaa gaacctccgt gatgaaagag gtcaaccata ctccaatgat 1500 gattttgcac ttgcatacac tggggaagga tccgtatttc tcgtaccaaa gagtgaaggc 1560 gaacaaggta gcattcacat aaggtag 1587 <210> 62 <211> 1995 <212> DNA <213> Artificial Sequence <220> <223> nucleolar GTP-binding protein 1 <400> 62 atcattgtga tacctcgtgt tgtttttttc cttttttcat caggcctgtt cagagaagct 60 tgtgtcatta tggctacaca ttataatttc aagaaaatac aggtcatacc aacgtcaaag 120 gatttcattg atattatatt gtcaaagaca cagagaaaga caccaacagt tgttcacaag 180 cattataaaa tctcaaggat cagacaattc tacttgaaga agatcaagtt cacccagcaa 240 aattatcatg acaaattgac gcaaattatt acagatttcc caagactaga ggacattcat 300 cctttttatg ccgatctgtt gaatattctt tatgacaaag accactacaa gcttgctctt 360 ggccaaatca atacagctag acacttaata gacaatgttt ctaaagacta taccagacta 420 atgaagtatg gtgatacaat gtacaggtgt aaacagctca aaaaggctgg tcttggaaga 480 atgtgtacaa taatgaaacg acaaaatcag agcttgcaat atttggaaca agtacgacaa 540 catttgtcaa ggttgccttc aattgatccc aacacaagaa ctttgttgct gtgtggattt 600 ccaaatgttg gcaagtccag cttcatgaac aaagtaacaa gagctgatgt tgaagtacaa 660 ccatatgcat tcactacaaa gtcactctac gtaggacaca tggactacaa atatcttcgt 720 tggcaggtga tagatactcc tggtattttg gatcattctc tagaagaaag aaataccata 780 gaaatgcagg ctattactgc tttggcacat attcgtgctg cagtgttgta tgtgatggat 840 ctgtcggaac agtgtaatca ttcaattgaa gaacaaattg agctcttcaa caacatcaga 900 ccattgttca ccaacaagcc aattgttgtt tgcttgaata aaattgacat tgtcacagtt 960 gatgaattgc cagaggaaaa acgaaagttg ctggatgttt ttaatgatga tggtatcacc 1020 gttataccaa tgagtacatt gactgaagag ggtgtcatag ctgtgaagac agatgcctgt 1080 gagagacttc ttgctcatcg agttgaagtg aagatgaaga gcaaaaaggt gggagaaata 1140 atcaacaggc tgcacgtgtc gatgccaacg ccaagagacg cgaaagagag accagccttc 1200 atcccagaag gagctgtcaa gaaaggaaaa ggtatggacg ttgataagtc tcagaggaaa 1260 ctgcaaaaag atttgcaaaa agagcttggc gaggactaca acttcgacca ccagaaattg 1320 tacgtgatgg gagaggacga aaagtatgac gtcattcccg agctttttaa cggcaagaac 1380 attgccgatt tcatcgatcc tgaaatcatg gagaggctag aagagttgga aagggaggag 1440 gaactgagag aatctgctgg cgtctacgat gaagaagtcg atgatatgga ctccgaagag 1500 gaagaaactc aaaaactcgc ggaagagatt cgaaagaaga agaagattcg tgttcaagag 1560 caccgggcca agaaaggttc aaactacccc acactgccca gaaaagcatc cctcaagctt 1620 gatagatttg gcagaccgca aaagagagag gcggatgacg aaattgattt caacatagat 1680 ggtgatcttg aaatgatgga tacggattct acacgtgcaa gatccgttgg tcggaagaac 1740 aagaagagaa aacacgaaga tagtgttgct gcgagtgcat cacgcgcccg aagctcttcc 1800 aagaagacgc cacgtgacca gtctggaatg cctgatccag tgaaacgagc caaggttaga 1860 aaattggcca aagtatctca aaggaaaatc aaccagtttg gaagggcagg tgaagctgac 1920 cggaaaattc agacgaaaat gccaaagcac ttgttttcgg gcaaaagaaa gcaaggaaaa 1980 acccaaagaa gatag 1995 <210> 63 <211> 1605 <212> DNA <213> Artificial Sequence <220> <223> nucleolin 2-like <400> 63 atgggaaagg acaagtcaaa gaaaaagagc aaggttgagg ttgttgaaga acccgaagta 60 gataccacag aagtgaagaa aaatttgaaa aaagaaaaga aagctaaaaa agcccaagtt 120 gaaaatgatg tggaaatgcc agaagtaaaa gttgataaga aggataagaa aaaaaataag 180 aaaaaggttg ttgaagaagt tgtagaagca aaaactgaag agaagaaggg gaaaaagggt 240 aagaagaaag tagaaaaagc aaagaaagtt gttgagaaga agaaagaatc atcaagtgaa 300 gactcaagct ctgaagaaga tgagccccca gcaaagaaag ttccagaaaa gaaggctgct 360 cctgttgtca aggctcaaga aagctcttcg gaggaagatt ctgacgatag tgatgaagaa 420 gaagaagcaa agcctgctgc aaagaaagtt gttgcaaaag aagaaagttc tgcagaagaa 480 gatagcgatg acagtgatga ggaagaggaa agtaagccag ctaaaaaacc tgtagtcaaa 540 gcagctaaag aagaaagctc atcagaagaa gaagatagtg atgatgagga tgatgaagat 600 gaagtgaagc cagctgcaaa ggaacagaag aaacaagaaa tggaggaaag ttcttcagaa 660 gaagatagtg atgatgatga agagatggca gaagaagcat caaaggaaca ggggaagaag 720 agaaaagtag aagctaatgg taatgcatca gatgaatctt cttcagagga agaagaagag 780 gaggaagaag caccaccagc aaaaaaacag aaagaagaag tcaagcctgc ctacactaat 840 ggaaacgacc agataaagtc aattttcatt ggaggtcttc cctggagtgc agatgataac 900 agtttgaagg aattccttga agaaaatgaa tgcaaaccca tcagtgttag agttattaca 960 actgctgagg gaaggtcaaa aggttttggt tatgctgact ttgaaactcc tgaggaagca 1020 acagctgccc aacaattaag cggaatagaa atggatggta gaaaactgaa tgttgatctt 1080 tctaccccaa gaaattcagg aaccccgaga ggaggaaggg gtggaagagg cggacgtgga 1140 ggaagaggag gaaccccagg aagtgggggc cgtggtggtg gagatttcga gcagccaagc 1200 tcaacattgt ttgttggaaa cgtgtctttt aatgcgaccg aggattcact tggaaagatg 1260 ttcaagggat gcaaagaagt cagatttgca aaagatagag aatctggatc attcaggggt 1320 tttgcttacg tggaatatga tgacatcagc tctgcgcaag ccgcacaaaa gaaggcagat 1380 ggcaaagatg tggatgggcg aagcatcaga gttaatttcg ctaaatcaag agacagtcct 1440 ggtagcggac gaggtggtgg acgcggagga ggattcaggg gaggccgtgg aggaggagga 1500 ttccgtggtg gtcgaggtgg acgtggacga ggcggagctc ccggatctgc agccaggaag 1560 ggatcaattc aagaatacaa gggatcgaaa atctcattcg actga 1605 <210> 64 <211> 1581 <212> DNA <213> Artificial Sequence <220> <223> phospholipase B1, membrane-associated-like <400> 64 atgattttca aatattggcc tgggattcag tatgtcttga ttttgttttg ttttgctgct 60 gtccacgtca gctgcacagg aaagcaacaa atgagggatg aagtcgaaaa gattccactt 120 ggcgaacgac tgaaggattt atggacgaaa aacgaagata agtatgagag cttttacgag 180 ttctttcaaa aagaagtcct accgaaatcc cgggaactac tcaaggacac aaacaccaca 240 gtacctgccg agttcttcag caaagagggg gagggagaag tgagcggcag tgacttccca 300 tgcaaattat ttcacaacca cacgaacccg aaatcagtgc acgaactaaa accgagtgac 360 gttgacttgg tcgcaggaat gggcgactcc atcacggctg cgttcggagc caagtcgaga 420 aatatcctcg agatattcct cgaatttcga ggcgtatctt ggagcattgg gggagataaa 480 acgttgaatg acgtcacgac actgccgaat atcatcaagg agtataatgg gaacgtggat 540 gggttttcag tgaaaattac cccacccaag atcagtatcc cttggaggtc gcatttgaat 600 gttgcagtat caggtgcgat ttcaattgat ctgcctggtc aagctacgac acttatcgag 660 aggctgaaaa gttatcataa ctacgaggac agttggaaag tgttaacact gtggatagga 720 ggaaatgatc tgtgtggata ttgcaaaaat gataagcata cagttgaaaa atacattgga 780 ggtatcagag atgcattaga cctactgcac aaagaggttc caaagatgtt tgtgaacttg 840 gttcaaatac ttgatgtcac acgactgaat gcaataaaat ctctttattg caagccactg 900 cattacatat tgtgcaaatg cggcacgtca gctggtgagg aggtgaaaaa aaaggtgtcc 960 caaatgtcta ttgagtacca actggctgta aaaaatctga tcaagtctgg aaggtacgac 1020 accagagatg atttcactgt tgttattcaa ccattttttg agcagacaac aattccccag 1080 aatccagatg gaagtgctga catgagttac attgcgccgg attgtttcca cttttcagaa 1140 aaaggccaca gggcagccgc actcgctttg tggaacagca tgattgaacc tgtcggcaag 1200 aaaagactca tgtggtcgaa aggagaaaat tttgaatgtc ctcctgagac atttccttac 1260 ttctacacga ataaaaacag caaaaactcg ccaatgcata cctcaatctc ctcacaactg 1320 acaaagaacg atgcaaacgg gcctttgata aaagaaaatg tcagacaaca gcagaaaaaa 1380 ccattgcaga atttcgctac aggaaaaaat ggcagctcca cggcaacctt gctcacaatt 1440 ttaacatgtg ctgttgtgtt aatagttgtt gttgctgttg ttgttatcaa aaggaggcag 1500 tcgcaaaatc aaaacgaggc ttgccagagg ttgctcgtgc cagaagacca agaagcatca 1560 tatacaggca taaactactg a 1581 <210> 65 <211> 792 <212> DNA <213> Artificial Sequence <220> <223> phospholipid scramblase 1-like <400> 65 atgtcgacac ctttcagtcc attagaagat cgtatcatag tgactgtcca gccagacgct 60 ggaggaaaag gtggtcaaac aattattcca atccccgaag aatggctccc tcaaccaccc 120 atagaaagag tgccagtcaa ctgccttcca gggctggagc acttggcaac actggatcag 180 attgtcatcg atcaaagata tcactggatg aaaagttgtt catgtgaatt tcaccagaga 240 tacgatatcc ttgatccaag gtctggacag caagtgtact atgctcatga agaatcagac 300 ttttgtgcac atcattggtt ggattctacc agaccattcg agatgggtgt tttcgatttt 360 tcgggaaaag aagtactaca tatgtctcgt ccatttcggt gtgctggtat gatgttgcca 420 ccctgtttgg atgaattcac cataacctca tcagatggaa gattgcttgg aactgtcaaa 480 caaacatttg cttggtgtct tccacgattt gatgtgcttg atcataatgg tcaagtgatt 540 tttaacatca aaggtccttg ctgtcactgc agttgcaatg aagtaccatt caagatttac 600 tctgttggtg aaagtacaga gtgtggtgtc attgctaaaa gatggactgg gtttgccaag 660 gaatgctgta cagatgtgga caacttccgc attcagttcc ctcccaacct tgatgtacgc 720 ctcagggcat gcttgctggg agcttgcttc tccattgatt tgctattctt tgagcacaat 780 agtaacgagt aa 792 <210> 66 <211> 2244 <212> DNA <213> Artificial Sequence <220> <223> poly (ADP-ribose) polymerase family, member 12 <400> 66 atggcgactt cacttgaatt tcagcttcaa gaaaataagc tgctccattg taaaaatgag 60 gcagaactgg ccaagaaaat ttacttgaga ctaattgcca ataaggatga gttaaatata 120 actgaagttt ctcagttaat tgtcaatgaa gagaaaaaga aggcctatca caaacaggaa 180 aataacagca cattgaatga tgtgaatgtt tttatcaata aatatgatca tctctttagt 240 gtaacgcttg ataaaggaat ggttgtcata agaccagttg tgaagattga attctgcaag 300 acatttgatg gcaaacaagg ctgcctggca agaagttgtc ccaagttaca tgtatgccgg 360 cattatatta aaggaaagtg cacatttgga gtgaaatgca agaaacctca ccactttgat 420 ggcccacaga caaaaaaaat attgagagaa cattgtttgg acggacttag tcccttgaaa 480 ttaaagagtt ttttatgtcg taatgtacaa tttgcattgg aggatatgat agatgcttct 540 aatacaccaa gaaatttgga gatctgtaaa tattataatg tagcgatagg atgcagcagg 600 gacgagcaat gtcctttctt acatgtttgt aggttctatg ccgaagaagg aacatgtaaa 660 tttgggacaa aatgcatacg aaagcatgat ttcaagaata aacatacaca gatgttgctt 720 gaaagataca agattcggga agctgaagtt ttgaggtatt taagaacgaa gagggatgat 780 aattctattg ctgtaccgcc tggcttggaa gacaacttta acaataattg catgcttgca 840 caatctaaat tattaagaga ttacgtacgt ctttcgaatg atgttgaagt tcgaccgaaa 900 ttcaggacgc agtcactgaa cgattgtaaa caatttgagt tatcatcgtc tgtattaccc 960 gcgcgcaagt cctccgaacc attgagtatg gagatgccag ccaaccttga aatatgcgat 1020 aaaatattca agggcgcttg taataataca ttacactgta agaaagttca ccgaacgacg 1080 ccttttagct gggaatattc atcaatagga tgggattggc atgcagttgg caaacaggaa 1140 aatctgaaaa ttgagaaagc attttgtgac gtggagcaga atagtgtcat tgtgcaatta 1200 ggtcaacatc ttggaaatta cacattccaa ttttctcatt ggattgctca tcgaactaat 1260 gagctagcga gatttcaaga tttgtctgcg ccaattttac tcatgattcg tcgattatca 1320 accgcctgcg ccatcacaaa tcagcattca acagaagaca gctcatatct cactacttgg 1380 atttggtact atggcgaagg tgacacagac aaatggcaca gctatgatgc tttcgattcg 1440 caatcaaagg ctgcattggc aatgaaaatg tccagtaata caatcgaatt ggcatatcaa 1500 ttactaggtc gaagcactct taatttcgtg ggtgtaaatg ggagaacatt cctgatcgat 1560 tttgatcgca tggtacagca agatttgcaa gcagggacga cttttcaagt taggcgaagg 1620 ccgttattca acgcaaattt tgacgaagat aaacaaatta aaagtttttc agatgaaaca 1680 tcatttttcc caagttactg gaattcgggt ttgatgagtg gattcccagg tgaagattgt 1740 gaattaatag atcttccatc aagttctaac gaataccgtg tagtctattt gagtttcatt 1800 gcaaccatgg agcatgttac agtgtcttgg attaaagctg tacagaatcc acggctgtgg 1860 atgcagtatg cctcgaaaag agaatcatta cgagaaattg atccaggtgg tgcaaaagaa 1920 atatatttgt tcagaagcac gagttgttca gatgccgaga gaatctgtcg ttatgggttt 1980 ggttacgatg tatttgataa ctgcagacaa gaatcatttt atttcgcaaa gaaagcgaaa 2040 gatgcatgcc atgccaatag caaaactgca agtagtagtt gttatatgtt ttgctgcaga 2100 tcaataacta gttccaaatc aacaggacat gaagcaaata catcgctcat aagagttaaa 2160 gccaatgata aacatcgaat gaatttttct gcctctgaag atgaaaacgt cttccccgaa 2220 ttccttatca aatatataat gtaa 2244 <210> 67 <211> 315 <212> DNA <213> Artificial Sequence <220> <223> procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 <400> 67 ttctggggag caattggaga tgatggattc tatgcgagat cagatgatta catcgacatc 60 gtcaaataca acagaatggg tgtctggaat gtgccattca tttcgaaaat tcatttgatg 120 aaggcatcag ttatcaacga tttgaagccg aacgcgttcc acagcgaata ttttgatgca 180 gatatggtat tttcaagtaa cctgagaaat gacggtgttt tcatgtacat aacgaatatg 240 gagtattttg gacatttgaa agatggtgac aattaccaga caacacataa gcataacgat 300 atgtacgaat tgttc 315 <210> 68 <211> 1194 <212> DNA <213> Artificial Sequence <220> <223> prolactin releasing hormone receptor <400> 68 atgttgaatc actcattcgc aaatttttca agcaacgtgg catgtaattt gagctcagtt 60 ctgaaccaga ctattaatgg tacaatccag aattgtagtt caaatggtac aaattcacaa 120 gaccaaaaaa attcaacagc aatagttttt cctgagcttt ggaaaatatc tttggcaaca 180 agaatcattt tgatctcaat atatgcattg atattcctaa ttggtgtctc aggaaatgca 240 atggtttgct atgtaattgg acgaaagaag aagaaaacag gtggagatgt atttgtaatg 300 tcgcttggaa tttcagactt gttggcgtct ttattcgtac catttctaat gattgctgat 360 ctacgaagtg aagaaaatcg ttggttcctt ggttctgcat tatgtacgat attaccatca 420 gtttcaccaa tgactctgat cgcatcatct tggtctttaa tgttgattgc agttgacaga 480 ttcaggataa taacaaagcc attacagcct agactatcga caaagttcaa aatcattgga 540 attatcgtag tgtggttggt tgcacttggg ataacagttc catacgcaat atcacaggga 600 gttgataaag atcaatcgat ttgcatcgac caaggtgtgc tcagcaaaaa agcaagaaat 660 atttacgtta cttgttggat cgtaacagga tggggtatac cgttcattgt aatttctatc 720 ctctatagta tttgtgtatt tgaattgatg tcaaaaaaga aatctaacag cgtcacagtc 780 aaacaacgaa gagatgagaa taaaagagtt gtgaaaatgt ttcttatcat tgtatcctta 840 tttttcatat ttacaacacc gtattcatta atgtatgtta cgtttaatta tctgctcaca 900 tacaaacgag aagcagttga tataaacgcc atcatgaagt ggaattatgc cttgttcgta 960 ttgacaacgt tgaacagttg tatgaatcca ataatttatg caaaactgca tcgtgaaatc 1020 aatccgtttg tgaagaaact tgcaggcaga gtcttcaatt gtgattccaa caagagaaaa 1080 gatggcagtg cttatgaagt ttcagaaaaa acatgcagca cacaaagatc agtcactaca 1140 tcctctacgg caagatcaac aacatatact aatcaagcct tcactgaggc ataa 1194 <210> 69 <211> 1491 <212> DNA <213> Artificial Sequence <220> <223> proline rich 11 <400> 69 gacctagtct tctacactcg atatctcaat cgaggctgca ttcgacccag tgctttaagt 60 agtacgacgc gatatttttg tattttcggc ggtttcgatg tgataaattt attgttttct 120 tcaacatgtt tgaataatat tgtgcagtat ctggatcctt cctggaagta ttgctaccac 180 ctcattatgc ccacttcgaa gtcaaggaaa tgcagactga ttgcaaagca gaagcgaagg 240 gaaaaactgg caataaagat gaaaggaaaa ttaggccaca atgtcatgca ttgtcgtaca 300 ttgcaaaaaa acagtagcat ttccaaagca attgcatcga ttgtggagtg catgaaagat 360 gttacaaatg ctagtaatgg tagagatgtg gaaagaaaca atatgataat tgaggatgaa 420 tatccaataa aagaacattg tttattattg gataacaata ctgataagca acttaaagca 480 gctgataacg aaggaaaaca tttagagctg cagcaaaata cagataattt gccaaaaatg 540 gtccatgaga atgattcgtt taaatcgaga agtcagaccg ctatagattt ggattttatt 600 tctaaaagtt attcagaagg tgctggtggt attgttaaag gagagagaaa aacttttatg 660 ttaagaaaaa tatttacgtt ttttgacgtc tcacaagttg ttcgtctacc tctgagcatg 720 atgaaagcat tttgccagaa aataaagact atttcttttg gagccaacgc atctttggca 780 agtgatgcta aactaattga taaattgaag caaagagttg agcatattga gaaggagatt 840 gagatactta aagactcgtt aaataataag tgtaaaaatt gcaatacagt ggttgtaaaa 900 ggagccaaga atgacagttc aactcaacta atgcctcatt ttgctcctcc gccgccacca 960 cctccgcctc cgcagttacc cattgcaaga gctgggagca aagataattg ccaaaaacga 1020 cagcaaacta aaataaagga aataaatcaa acatcaaccg acgtgcgagt tacaaaagac 1080 cagctgctca aagtcaagct gaagcgcgtt tcatttggaa gttgcaaaaa agagtcgcaa 1140 aatcttgacc cgcctgttat aacactgcaa gacatacgta acgtgaaact gaaaaggagg 1200 ccacttgata aagagaacgc gacaccgctt agagatattt caaatgacgg tgtcggagga 1260 aggccactac tttccatgga taagaggaca cctttgtcaa gatacaatct acgaaagacg 1320 ctgaagaagg ttaacatgct cagaagcccg ggtgggacgc cactcgtcaa agcgaaaatc 1380 gaatgcggac agggaatgac ccccctttta actggagcat tgcgaaggaa gttcaagaat 1440 gttaatccac cttctgcgga agatagtcca ttggatttcg gagacctttg a 1491 <210> 70 <211> 2706 <212> DNA <213> Artificial Sequence <220> <223> protein argonaute-2 <400> 70 atgagcaata acaatgggcg aggaggagaa ggcagagaaa agaaaaaaag aaataaattt 60 aatggcagaa ataataatgg atccattaat ataactttga acaacctttc cataaatggt 120 catggttcct ccataactca acagaaaata acaggacaac aagttatgct gcccacacgt 180 tctggctttg gaaaggccgg tcgaaaaatt cagttgtccg caaacttttt cgaagtttca 240 tttcccgacc acgagatata tcaatatgac gttacactcc aaccgagttc ttgtcccaga 300 caacttaacc gagaagtcat tgaaaaaatg gtcgcattct acagtgacat tttcggagaa 360 caaagaccgg tttatgatgg tcgaaatgcg atattcacaa tcagaccgtt gactatcagt 420 ccacctaagc aagaatttct tgtcaaatac attgatgaaa aggaaagcaa agaccgagaa 480 tttaaagtga caattaaata tgttgcacat acaagcatgc tggcattaca ccaagtgctg 540 cgcaatcaga catcttccat gcctcataac accatacaag caatggatgt tgccatgaga 600 catctaccct ctttaagata catcccagtt gggaggtcct ttttttcccc tcctgatgaa 660 cctggctgct accaacttgg caacggtaga gaggtttggt ttggctacca tcaaagtctc 720 cgaccatctc agtggaaaat gatgatcaat ttggatattt catcgagtgc tttttacaag 780 acgcaaccag ttcttgatct tctctgcgag gttgtccagg aagactttaa gaaaaagaaa 840 aggcaactca gggatcatga aagagtgaaa tttctgaaag agatcaaggg gttgaagata 900 caaataacac atctaggaaa agccaaaaga aaatatcgtg tcagtggagt gactttatta 960 tcaactggtt gccaaacgtt caaaatggaa aatgatggcc ttgtatctga tgtcacagtt 1020 gcctcttact ttctagaaag atacaatttc aaactaaagt acccaaatct tccatgtctt 1080 caagttggtg atccttccaa gagtgtttat ctgccaattg aagtctgtga agttgttgct 1140 ggtcaaaggt gtttgaagaa gttgaacgag aagcaaagcg ctgagatgat caaagcgaca 1200 gttacaagtg catcaagacg caaaaaagaa attcaatcaa tcgctcgcaa ggcagacttt 1260 tccaatgatc catacgtgaa gtactttgga attcaagtga agccagatat gacagttttc 1320 gacggaagag tgatcgattc accggttctt cagtacggaa acgagttgca aacaaacaaa 1380 gctcaagaaa ttaagccacg aaacggggta tggaacctac aagacaaatc attccgttca 1440 tcaacggcaa ttgacaaatg ggccttagtt ctttttgttc aagaaaaaca atgcaattac 1500 caggccgtga agcaattcgt aaacagcctg gttgaagttg ggcatggctt gaatatgccg 1560 tttgctgcgc agccactcca ctgcgaatac gcaagcagaa atgcgaatga cgtcgaagga 1620 ctattcggca cattgattgc caatcatttg gatttacaac taattgttgc tgtactctct 1680 ggaaagacac cactgtatgc tgaaattaaa agacttggtg acacgttgtt tggcgtacca 1740 acacaatgca tccagatgaa gacagtttta aaggcagcca agcaaagtct tgcgaatgtc 1800 tgtctaaaag tcaatgccaa actcggaggc atcaatggca tcatagcgcc aagatgcaag 1860 ccaaagagaa tatttgacaa accagttgtt tttcttggag ctgacgtcac tcatccggga 1920 ccaggagacg acacaaaacc atcgattgca gcggttgttg gtagtatcga tgcacacccc 1980 atgcattact gcacttcagt cagagtccaa aagcatcgcc aggagatgat agcagaattg 2040 tcaagcatgg ttcgtgaaat acttttggcg ttttacagat ctacaaggaa caaaccatcc 2100 atgatcatca tgtacagaga tggagttagc gaaggacaat ttgcacagat cgttcaacat 2160 gaagtacatg ccatacgaca ggcgtgcaaa agcctggagg ctgggtacga gcctggcatc 2220 acttttcttg tcgtacagaa gcgtcatcat gcaaggtttt tcgccgaacg acaatctgat 2280 caggttggaa aagctggaaa tatcccccct ggaacaattg ttgacaggca tatatgtcat 2340 ccgagtgaat acgatttcta cctttgcagc catgccggta ttcagggcac aagtaaaccc 2400 gcgcactacc atgtactgtg ggatgataat aatataacgg ccgatgaatt gcaacagttg 2460 acttacatgc tttgccatac ctacgttcgc tgtactcgct cagtctcgat cccagcacct 2520 gcttactatg cacatttagc tgcattcaga gcgaggtttc atctcatgca gaaggaagga 2580 agcattgata gtggcagtag cagcacgcct tccgtctctt cttcggaaca cgaaattgga 2640 atctcggcaa tgaccgacgc tgttaggcca cacgtcaagt tggcgcagac gctgtatttt 2700 gcgtaa 2706 <210> 71 <211> 1038 <212> DNA <213> Artificial Sequence <220> <223> protein kinase, X-linked <400> 71 atggcgaaca aagccgtcat ttcttacagt aatcatgcaa ttgccattgg tactgaagtt 60 tgttataaca aattaagaga ctacacgcct gaagacttcg atatcatatc tacaattggt 120 tctggaacat tcggtagagt ctttcttgtc caagacacca aagatgaaaa atattatgca 180 atgaaggttt taaaaatgaa agatgttttg aagcagaacc aaattcaaca tgttctcagt 240 gaacgaaaag ttatgatgaa ctgcagttgt ccttttttcg tcaaatgcta ttggacatat 300 cgctcatctt cgtgtctttt tcttttattc gaatacatcc cgggtggcga gctatttact 360 tatttacgaa acaagaccaa ctttacatca ccagaggcac tgttctatgc atcggaggtt 420 atcctcgctt tggaatatct gcaccagaga gaggttgtgt acagagatct caagccagag 480 aatgttctca ttgatgctca aggtcacgtg aagctcaccg attttgggtt tgcaaaggaa 540 attcgcgaca tgacatggac cctatgtggt acaccggatt acatagcacc agaagtaatt 600 caaagtaaag gacataattt tgcagttgac tggtgggctt tagggattct tatttatgaa 660 atgattgtgg gtacacctcc ttttgttgac gaatgtcaat ttggaactta caggaagatt 720 ctagaagggt atattgattg gccaaagaaa ttagagcata ccaacgaaca ggatttgatc 780 aggagattgt tgatagcaga tagaacagca aggcttggag gtgcaaagga aggctcttta 840 gaagtgaaaa gccatatttg gtttgctgac gtgaattgga acgacgttta cgaacggaaa 900 accaagcctc caatgatacc aagattggct catcttggtg acacgagtaa ttttgatgat 960 tacagtgacg acgaggaatg gatcgaagac gcagcccaaa ttggaatcgc tgatctagaa 1020 ttatttagtg atttctga 1038 <210> 72 <211> 1032 <212> DNA <213> Artificial Sequence <220> <223> protein lifeguard 1 <400> 72 atgtcagagc caaataagga acaacttgcc acagaacccc ctccaccccc atattctgca 60 gcatctacat atccaacatg caatgcccct taccctacag attatccccc accaccagct 120 gcctatcctc cttctggggc tccttatgga acaaatactg caccaccacc tgctccatat 180 ccctctggat atggaatgga tgctccacaa ccagccccgt acccaaacaa tgaccctaat 240 gcaatgagta atcccagctt tgcacctcaa aatgaccagc caccaagcta tacggaaaca 300 gggatgcctg atgcaaacgt tgaagctggc tacaaagatg atttgggaat gatgtcattc 360 aaccacaaat ctgtcagact tggtttcatc agaaaggttt atgggttgct tgctttgcaa 420 atggttgtaa caattgctct ctcatgtctg ttcatgtttc accaacccac caagatgttt 480 gttcaaaacc atttctgggt ttatattgtt tcatatgcct tgtttttggt gctttatttt 540 gttttgtgtt gttgcacaaa agttgcaaga agctacccag caaacatgat tctgcttgga 600 atctttactt tgagcttggc gtacatggtt gctgccataa caagctttca caatacaatg 660 atcgttctta tggtttttgg aataactctt gtggtcactg ttgcagtgtc tatttttgct 720 tgccaaacaa agtatgattt cacaacatgt ggaggtctgc tctttgttct gacactgtgt 780 cttatcttct ttggattatt tgctgctgtt ctcgtcccaa cgaaccagat taggattgca 840 accatggctt atgcattgct cggggcccta ttattcatgg gtttcttggt cttcgacact 900 caattgatta ttggtggcaa caaatacgag attgatccgg aagattacgt ctttgcaacc 960 atgatgttat atgttgatat catttacatt ttcctcttct tgctttcttt gtttggtggc 1020 agtggtaact ag 1032 <210> 73 <211> 1023 <212> DNA <213> Artificial Sequence <220> <223> protein SpAN-like <400> 73 atgaagacaa tgattttatt gccactgttc ctcattcttg ttcttcaaca ccaagtccaa 60 tgtagaaaac atgttgcaga aatctgtgga cggggccaag gtaacaaatg ccctgaaact 120 ccagatgaaa ttatcgaaga gaaaaaggca gaagaaaacg acgacaatgc aagcaaagga 180 aagttcttct accaaggaga tattagatta acaaaaccgc aaaaagaaaa acttgataaa 240 aaattgaata gtttcagacg agatgtttct gattatgacg atatcaaatg gcctgatccc 300 cagaatataa aatatcagct tgatagtact attgatgagt ggggaaggga agcaatagaa 360 ggtgcaatgt ttgacttcca tagatacaca tgtcttagat ttcatgaaat gaaacccgat 420 gataaggaca aagatttcat cagattcatc aaagaggatg gatgttggtc atacattggg 480 aaactggatg aggaagatct ggctgacgga tatgagcaag acatttcaat cggagaaggc 540 tgccagtaca aaggaacagt aatacatgaa atgatgcatg cacttggctt ctttcatgag 600 catagtcgca ttgacagaga taagtacgtg aaaattttgg atcaaaatat agaggaagac 660 atgcaagatc aattcatcat taacgaagat cagaaaaatc ttggcgtggc atatgatttc 720 aacagtgtca tgcattatcc tcttgatgca ttcaccaaaa atggtctgcc aacaatcgaa 780 gtggtcgggg atgcccaagg agctcagatc ggacacagag atggaatgtc agccaatgac 840 attgagcaaa tcagattatt ctacgactgt aaggatgcta ggagaacgca tattccaaag 900 aatggaacct tgcatcatag cttcaagagg tatacaaatc gccgtcgcag cggcagcacc 960 tcgaaaacac atgattccaa gggcggcctt tgtgaaggct atgcggaggc agaaagaaaa 1020 tga 1023 <210> 74 <211> 2841 <212> DNA <213> Artificial Sequence <220> <223> protein tyrosine phosphatase, receptor type, D <400> 74 aagtttcgga taggtggaaa tgaagagaat gtgacgctct actctgttac aaacctttat 60 gggcacattg tagcttatca ggtcattgtt gaaaggatta tctcaagcac tgctgtatct 120 aggacttctt ttccaaacct gagaaagaaa acagaagcaa gacagcataa cctgacgtat 180 taccttgcaa cagagaagct tgctgatgaa atgccaattt taatgcaatt tcaacctggt 240 gttgcttatg tcgaggcttt taatgccgat cttgacactc ctggaaacta ctatttgcat 300 ttcagagccg catcacaaac ttatggaaaa ccaaattcgc cacgtttatt tggagcaaca 360 actgtatatc atctagagcg taccttgttg aaacaacttc caaagcctga aaaagttgac 420 attggattca ctaccattaa atttaaagtt tctgtaactt taccacaagg attcatagta 480 aaatattact atatcattgc tgttgaggta ttggcagaaa gtaacctcaa tgacccatca 540 tcttaccaag atgtagattt gaaaaagtat gacccaaaaa cttatcagcc aggtacaccg 600 tacattgctg cagttctgac cagcattgaa tatgatagat tgacacattt cacattgggt 660 gatggcaaga catccaaagt tatatcatca agacgaaaaa gacagacaag agctttaaat 720 gaggaatatg tgaacacagt tttaaagcct gacaagtttt actccgtttt tctacgtgct 780 gtatctacat cttcttcaca ttattctaca ccttggatgg ctaaagtaaa aactgcttct 840 ccgccgaaca agaatcctac aggctcaatt gttaccattg ttactggtgt ttgcgtttcc 900 attgtggttg tcatagttgg cgttgtttta ttcttcttaa ttagaagaag aaagaaaaat 960 catggcaaac atcaaagtgt agatgatctg aatgaagttg aagaacacga aatgtcaacg 1020 aggaaccaaa agcgtgaaag aaacaaatta aaagctaatg tttcggcacc tgcactccct 1080 tgtcaaccaa gaaatctcaa agtgttccag gatcgagatt ttcctttgtt tgctgtaaaa 1140 gatattgttc gaaatgttcg aaacaaatca tccatgtacg atgcaggctt caaagaagaa 1200 tttcagaact taccaaaaag tcagttgttt acatgggatg ctgcaacaat gtcaaacaac 1260 aagccgaaaa atcgatatgg aaatatcatt ccatacgatt tcaatcgagt aaaattggta 1320 acgtcttcag ataaatccga ctacattaat gccagtttca taacggatta tcatggtaac 1380 cagaggtata taattactca agctccaact tctaaaacga tgggagactt ttggatgatg 1440 gtttggcaac aagaaattcc tgcaattgtt atgcttacga aatgtttagg aagaaacgag 1500 ggaaagtctg atgaatactg gtctccttcg ggtcgaaaaa aacacggtga tattaaagtt 1560 gctttccttg gaagtgaaaa gtacccagaa tgcaccattt ctgcaattga attgcaaaac 1620 gctacaacag taagaacatg caaacatata cattatacag catggcctga tcgtgacttg 1680 ccaatctttc caacaacatt gcttagcctt cgaaggcgat tgcgacaatt gtttccctat 1740 gattcactga acagcaagcc aattatgatt cattgcagta ctggtgttgg tagaactggc 1800 atattcatag ctattgatac tctcattcaa ctaattcgcg aacaaggaaa agtcgatgtg 1860 ttcaattatg tcaacttgtt aatgatgcag cgttttagta tggtgcagaa tgaggtacaa 1920 tataagttta tctataactg cctccttgaa gaagcagttt gtgacgtcac tgaagtttcc 1980 acggaggact tcaaacaaag atttcatgat ctaaccagcc aggatcgcaa gactggccaa 2040 aatggatttc agcgagaatt ttcgtctttg tcccttctgg cttcagaagt cgatgagcag 2100 gaatattcat gtggaagaag atcttatatc agtcataaaa acagagatgc cactgtgtta 2160 ccaagaaata cacaaagagt tttgctgcca gtgttgaagt ctgtggaagc cagcgaatac 2220 atcaatgcag tgtttgttga tggtggcaaa aaagatcagt tcattgcaac ccagtcacca 2280 cttgaaagtt caattgctga cttttggcgt atggttatcc accatggatc aagtataatt 2340 gtctctctta ctcattctga tgaggcatat acaagatatt ttccaaaaaa aaagcaagct 2400 aaatatggtg atgggcaatt gacgatcagc attcaatttt gcgatgaaat tgggaaagac 2460 ataatattga gaaaatttgt tgctactgat catatgttta acaagacatc aactatgata 2520 caccattaca gcatgaattc atggccagat cattctattc ctgaatcaat ccttacactt 2580 tctcaactaa tcagtgaagt tgaaaaaatt caacaaacat ttggtggtgg accaataatc 2640 atcaattgca gtaatggtgc aggaagaact ggtactttca ttgctgctta catgattctt 2700 gagattttga aaaccgaaca atggcttgat atcttccaag ttgtgagaag aatccgtaca 2760 actcgacctg aatttattga gaactgggag caatacaagt tgctgtatga tgttgtaaaa 2820 agttacttgg aacaatcatg a 2841 <210> 75 <211> 1110 <212> DNA <213> Artificial Sequence <220> <223> protein Wnt-4-like <400> 75 atgaagttgg ttaatctgtt gtttcttgtc gttttgtgtc ttcatgtttc cgagcggacg 60 tccgctttcg aatgggtatt cgttagcttg agcggactat caagaaaact ttcaagccgt 120 cgagattgta gccgaacgtt ggagcctggg tcctaccgtc acatgttatg tcatcaaaca 180 ttctcgcgca tgcaaagtgt aaagaaaggc actcgtatgg cttacagaca gtgcgcaaag 240 ctcttcaaaa ccacgcactg gaactgcagt gttttggaaa cgaaaaagca aacagattca 300 ccttttggcg atgcactaaa aggtacaaga gaagcggcat ttatcagtgc agtgtttgct 360 gcgggagtgg tatatgcaat aacatcagat tgcagagatg gtaaaatcga aggatgccaa 420 tgcgatagaa gcatgcattc aaatagagtg tatggcgaca gtataattgt gacaggatgc 480 agtgaaaaca tcaaatatgg attgtccttc tcggagaaat tcatagacac aggcgaaatg 540 atggacaggc atgtgaaaac aagacgttca aacgaaatac tcacaatgaa tttgcataac 600 tatggagtgg gcagaaaagt aatccaagag agtttaagac gcacgtgcag atgtcacggg 660 atgtctggca catgtgcaac aaaggtctgc ttcaaacagt tgccacaatt tccagatatc 720 gctaaaagta tcaaaaagaa atatgagcac gccacctatg cgaagattat cgtcacaaac 780 aaaaacatga acagaatgtc attggttccc gtctggtcga acttgaagaa aatcggagtt 840 gatgacttgg tttacctggt tccttcgcct gactattgca aatacaacaa gacgctcggt 900 gtgcttggca caacagggcg tcgttgtaaa atcggtaacg atggctctat gaatcttcca 960 tccgagcatt gcaaggtact atgctgtggg cgtggctttt atgccaaaaa gaaaattatc 1020 aaagagaatt gtcattgtaa attcacgtgg tgttgtcgtg tcagctgcca gtcgtgctac 1080 aagacaaaaa ttgtccacgt gtgcagataa 1110 <210> 76 <211> 1356 <212> DNA <213> Artificial Sequence <220> <223> protocadherin Fat 4-like <400> 76 atgaattccc gcacatgttg gatgctagtt gtgcttcttg ctatttttgt tgatgatggc 60 atggcatggc gacgaagaag aagaagagct ccacctccac caccgcctaa ttgcggcgta 120 agtgcttgga gcagttggtc tacatgttca caattttgct cagttggtac acagtcaaga 180 acaagataca taacatatag gccaagtgca tcttgcattc agccaagcct gacagaaagt 240 cgtcagtgtg gtgtgtctca cggtgggtgt gcccacaact gtgacaatac taaccacgtt 300 tgcacgtgta gatctggcta caatctaatg tcagatggaa aaggttgtca ggacgtcaat 360 gaatgctcac caaatggtgg aaaaggtcca tgttctcata cctgcaccaa tagtgctggc 420 agctttgcat gtagctgtcc acataggtat aatttacata gcgatgctaa gacatgttta 480 cgagcagcga acaacccgcc aagccacatc aaattcgaac agtacaaact gtacgagaat 540 gcaacagctg gtttctatgt tggacggctg gtggcggttg ataaggacgg tgatgtcatg 600 tccttctcca tgagccagac cacatccaca gcgtcggagg tcttcacact cggctcaatc 660 ttgtgtagga atgtcccaac agccagcaat ccattgcaaa gtgaatgtgg aacgcatgtt 720 atattaatga ggccattgaa ttacgagtca aagagcagct acgttctcaa agtgacagcc 780 acagatccaa tggggggctt tgtcacaaaa gaattcacca ttgtcatttt ggatttaaac 840 gaatctccga cagacatttt gctttcatgt caaggtgttg cagataatag tactgcagac 900 acaattgttg ctcaaatcac agttgttgat ccagatattt ttcatggttc accccagcaa 960 cacacatgta cagtgagtcc atcatctcct ttcattataa gtggacttaa tttggttgtt 1020 gccagaaatg ctgcgcttga tttcgagcag aagtctctat atgtcatttc cataacatgc 1080 actgatgcag gaataccacc tttgtcatta tcaaaagtgt tcaacattag agttcgagca 1140 cccacctctc cttccaccaa catcaaaggc gtttgtcctg agggtctcac tggatctaat 1200 tgtgaaagat attcaaatat ttgtaacagt aatacatgcg gcacattcca agtttgtgtt 1260 agccacgtgg aatgggtttt gaagtgtatt tccccgtcaa atcagattcc agtcttgtta 1320 cgtcagtctt acatgactgt ttcagtacct gaaaat 1356 <210> 77 <211> 1095 <212> DNA <213> Artificial Sequence <220> <223> pyroglutamylated RFamide peptide receptor <400> 77 atgaatatat caacaacttt aattccgaac acaacgctgt atactctaac tcgtgggttt 60 caaacgatga cgaatgcgac gaagccagca ggaagaggcg ataaacctta ccctcctttg 120 atcaagaaaa ttggactatc agttataccc atcataatat tcctggcagt gtttggaaac 180 tctctggtca tacacctgtc aagaaagtac agtcttctca aaggcccgat gagactgttg 240 gtcatcaact tatccatctg caatatcatt ctgtgtttct ttccgctcat gtatattgtg 300 gaattggcca ctggcgattg gcatttcggc agtaaagcct gcgacggttt agttgtcttt 360 gaatacgccg ctttgacgtc agcgaaaatg acgctcgtct gtatcgcgtt ggagcggtac 420 accgcgctgc tcaagccgtt caagaagaaa gtcagcgcgt ctcactcgaa atggatgcta 480 ctggtcgcgt ggttgattgg ctggcccttt gctataccgt tcgtaatcct gcaaccgcgt 540 tacgttgatg atgatcatcc cgatgcggcc gcgcaacccg aatgcaacaa catgtgggcc 600 gttacgacgg tggggatgac aaaaaccgcg ctcggttatt actccatgat gttcgtcgta 660 ctttacatca cacccatgct gatcatgtct ttctgctatt tccgtgtcat acacgttgtg 720 ttgaacaaga tgaagaggcc tggtgaccag accgacaaga acaaggccga ccaaaggcgg 780 caaaaatggc gcacaattaa aatgctcatc acgacagtta tcatttttca agtctgctgg 840 ctgccatcgt acattcaaga gttccttttg gccggcggct tggagaagaa aacggataat 900 ttgaagattc aggttgtcaa tctaatatgt ggcctaattg gttacctgta ctgtgtattg 960 actcctgtta tttacttcat ctttaatcag aagtacagaa aagcattggt tgacttttgg 1020 cattctttgg ggaaaactat caggaagcct ttacggagta ttgcacatcg tggtaccctc 1080 tcaacggata tttag 1095 <210> 78 <211> 468 <212> DNA <213> Artificial Sequence <220> <223> radial spoke head 10 homolog B <400> 78 atgggttgta tttgtcccag cagaagatca tcttcgaacg aagatgaaag ttccaccgag 60 tacgtagagt atagtaatta tatcggagaa aagaactgtt gtggccagaa gagtggaagg 120 ggccagtatt attacgacaa tggagatatg tatgatggca tgtggaaacg caacaaaaaa 180 catggatatg gagtttacac gtataagtct ggcaaatgcc tggatgggtt ctttgaaaat 240 gacagattct tgggcaccat catgccagaa catttgctat atgaggacga agatgcagat 300 gaaccattac caaaaaatgc agatgaccca gcaagttgga gaaatgatca aaccccagaa 360 ttgtcagaag aattactcca caagaaagag gagagagaaa aacaaaaacg ggaacatgaa 420 aaaaggatag agaaaaagaa aaagaaatat gggatcccat caaaataa 468 <210> 79 <211> 3015 <212> DNA <213> Artificial Sequence <220> <223> retinitis pigmentosa 1-like 1 protein <400> 79 atgaagaaga aaggtactga cgtcaaaatg acttcaaagt caaaacgaaa cacaaagatt 60 ttgtctactt caatctacga cccacattta attaccaaac agaacacagg aaatacagag 120 aattcaaaat ggaaactgct tggcagccca gcacccggca ttggcaggag aacaagacag 180 ccacttggaa taaaaattat aaaaatgaaa gatggacttg atgcagtcag tggctacttt 240 cccccatcag aagatgaaag cgaatctgaa tatcagtcag aatctgggtc ctgcgcattt 300 tccttggttg atgaacagca acatgaacac gcagatgaag aaaagatagt tgaagaacgc 360 ttggaagaag aagataatct tgttgactcg tactttgatg aagaggtatt ccaagataaa 420 cagaaagatg aaacaacaac aacaaccgct catcaacgca aactggttga ggaatcagat 480 attgaggaaa gtcacttgga agataatgtc agaccaatgg tggatggcaa agaattagag 540 tcactggatg ataatgaaaa tattgttgag agcaataatt gtgatcaaga tgatcaaggt 600 gatcatgatc atcatgataa tcagggtgat catgataatc agagcgatca cattcaagtt 660 aatcagagaa ggagatcaca acgcaaatcg tacaaagaca cagcagtgtc tactgagcct 720 cattatgagg catctccaaa acatcataat gtcacagttg gcaccaatac atctaatggc 780 gacatcagat gcaccaattc agctgctcgt agtaaatttc gagatgggag acagcgaagc 840 aaggcttgtg cgagaaatca tgattatgat gatgatgaca gaaatgagga ggaagccggt 900 aggtcactaa aacctggacc aaaattgaaa cacagaaaaa ggacccatgg aaggtacagc 960 caacggcttc aaccattacc tgatgcatat gataattctt catcggagga cgaaagagaa 1020 attcatcaac ggggcaattt tcagtctgtc cccgcgcgac tgaaaagaaa ccacgcggga 1080 attaacaagg aaaccctgaa gagaaaaaag ttagaactgg tgaacagatc tgaaaggaag 1140 cccgcatcgg caagatcaag aaatactaag aagcaatctg cgcgctgtga aatgccaaag 1200 aagcatcgga agaaaagtgt tcagttcagg gttcaaacgc cgatcacaga tgcgagcgat 1260 gtcgccgaaa gagaggtgga cgacgcgcat gagccaccat tgaatggtat tgatgattca 1320 gaggctgatt cacgtgacga ggcaccaaca agaggctggc gacaggaaag acctgttgga 1380 atggcaagga aaagtagacg tagtttggtg caagcgaaat caacgcccat ggttcagaca 1440 aataaggtaa ataaggagag tgaggttgct tgcaaagctc ctcctcatcg gatcactccc 1500 acccctggta atgtgaagag gagaaggagg tcgtcgaagt tgaattacgg cgcgaaaaaa 1560 agaaagagca acgtcgttgt taaggccaca actgatatct caagtccaga aagtcgaaga 1620 atatcgcctc gcgagtcgcc gaaagttgcc aacacgccta tttctattca gcccactaag 1680 aaaacagtca gtacacccct ttcgacgaaa gttcaagaaa atagaagaat atcgcctcgc 1740 aggtcgctga aagtcgctaa cacgcccatt tctattctgc gcaccaagaa agcagtcagc 1800 acaccgctat cgacgaaaca aaatcgtagg gtgagcattc ctgaaacacc tctgaacgtt 1860 ttcgaagatg acgaaaatat ggccccgttg ccgctatcat catggaaggg catatcaccg 1920 tatctgtctc caccaggccg cgagccaaac acaccgcgca gaacacttct ggcaaaagca 1980 gcagttcgtc gaagcgttgc tcgagatgcg acgctaggct caccacaaca gcaacaacct 2040 cgatccgctc gctcacgtct gtccgaggca cgggtctcgc tttcaccact tcgaaatgat 2100 aatgctgatg atgatgtaat cgacaatgtt agtcacaaca cgttgcccgg aggatcaatg 2160 tcgtttgacc tacccttgcc tgcgaaggag cttgacgatc aaaggcagca acaaggatcg 2220 atacccgtga gtcagaaggc tgcgaagacg cgaaagagga aggcaaaacg gataaatcca 2280 acgagtggag cagcagcgaa gaggaagact gcacgcaagc aaaatagaat tgatggtcta 2340 gagattcccc cgtcgaaaat tcaagacata ttgaatgatg cagacaatcg tgaagaaggc 2400 cctaggcggg ggaatcgaac acgagtcccg ccaattaaat actggaattt aaatgaatac 2460 attgagtacg aaagaagaaa ttcaggttta gtcattaaag atgttgtcag aagtgagaac 2520 agccctgttt ataggcctaa atcgaaacca gcgacaaaga agaagcgtgt tgcagcaact 2580 acctcgactt cctcagatca ggatgaggat ttcagcgatg aggtgaaccc tgtacagctt 2640 gtcagagatg ctagcgacca gctagttgca atgagaatct tcaacacacc gcagatgctg 2700 aatttagtcg ccccggggcc tctaccagat ggtactcaag tcagcaatct cttgattcac 2760 aagtttttta atcatcgtct cttcagtgtt ggcacactag ttatcctgcc aaagtctgag 2820 aaagggctgc agatcgtgga aaacgataca atgttgttct ttgtccagaa aggatctgtg 2880 tccgtcacaa ttgaagaaag gacaactcag gttggcaaag gctgcacgtt ctttgtgcca 2940 tgtggcaatt gctacaatat cgaaaacttg ttggataaga aagctgagtt acagtttgta 3000 cagataaaag gctaa 3015 <210> 80 <211> 663 <212> DNA <213> Artificial Sequence <220> <223> retinoic acid receptor responder (tazarotene induced) 3 <400> 80 atggggagtt catcttcaaa atcgtctgcc tcagatcagg aagacaaccg atcaacagcc 60 cttgttttgt acgacagaat ggctgctcag caagctgcta gacacgatac atctgatttc 120 actgctcccc aagacttggt tcaccatttg agaccaggag atcttgtcca gaaaaaagga 180 accatgattt ggcagtggtt ctacacccat tttgccgtgt tcattgggaa tggcgaaata 240 gtccatgtca caggacctgg tcgatttaag ggagaaatcc tcagagaaga catggttaaa 300 gcttttgcag gggaagacgt tagaaagaac aaccacatgg atggaaactt cacccctcgt 360 ccatggcaag atgtggtacg cactgccaga gcatatgtag gccaggattg gaattacaac 420 tttgttgccc acaactgtga gcattttgca tcaatgtgcc gctatggtag gaaaatcagt 480 ctgcaatcac tggctatttc cgatatcaat ggcggtgatt tgaccattaa tgaatatgtt 540 gcgtatcatt ttaaatcggc caaggagaag tgttccgtgt ttttcagctg ggtgaagaga 600 aaggcagtca cgtattttcc atatttgttt ggtcctagta ccacagaagc tatcggctac 660 tga 663 <210> 81 <211> 489 <212> DNA <213> Artificial Sequence <220> <223> ribosomal protein S13 <400> 81 ccctgtcctt tcttcttcac aaaatttgcc aagatgggtc gtatgcacgc accaggaaag 60 ggtatttctg gctcagcctt accttacaga cgaagtgtgc caacttggct taagctcaca 120 tctgatgatg tcaaggagca gatatataag cttgcaaaga agggtcttac tccatcccaa 180 atcggtgtca ttttgaggga ctcccatggt gttgctcaag ttcgttatgt gactggaaat 240 aagattctcc gtatcttgaa agccaagggt cttgcaccag ccttgcctga agatctttat 300 tgtttgatca agaaggctgt ggcagtcaga aagcatctcg agaggaacag aaaggacagg 360 gattccaaat tcagacttat tctgattgaa gcaagaatcc acagacttgc aagatactac 420 aagaccacaa gagttcttcc tgcaaactgg aaatatgaat ctgcaactgc atcagctctt 480 gtcgcgtaa 489 <210> 82 <211> 1887 <212> DNA <213> Artificial Sequence <220> <223> RNA-binding motif, single-stranded-interacting protein 1-like-1 <400> 82 atggttagtg taagaagtaa tgaagagaag caccaaagat tggacggagc aaaacgagtg 60 gataccgtgc gttcatcaaa ggatccttcg tcaacatcat ccgtagccat tagtagcctg 120 aagcctgcaa acgaagctac gaatgaaatc aatggactga caaataatca caattgcgaa 180 gacgacgaat ctttgacaac atccactact agcattacat caagtattga tcaaaacaca 240 cactctcctg tttcttcacc tcctgcctct gcaaccaacg gtaattcgaa catgagtgac 300 tcacaaaata atagtgacat tgaggcgaag gtgtccaatg gcccaaacag cagttccgtg 360 gacagcgatg tggacaccgc cgatatcggt gatgttgatg attgtgattc ggacattaga 420 aagaaaccga tttcctcgca accacaacca aagagaataa taaccagaga aaagaaacct 480 gaagatcgta aacagacaag aagccagtca ccaaaaggca cctacggtag atcagtgaga 540 cccggcctcg ttcagccgat ggtgtggcca gcctcgaacc tgccccaaaa ctgggcacaa 600 ttcagcggat atcactaccc gggacaagca aggatgcctg caccaatggc tctcataact 660 ccatatgcac cggcttacat gccgatgtct ggtgggagag atggtcgagt gggccagtca 720 ccgactcatt cgggaagcaa ttacatgact tcacattcgc ctcacgcggg cgaaaaactc 780 agcaaaacta atttgtacat aagaggactt atgccaaaca cagctgatga ggacttagtt 840 gtcatgtgcc aacagtacgg tacaatcatt tctacaaaag ctattttaga taaagataca 900 aataagtgca aaggttatgg ctttgttgac tttgacagcc cttattcagc ccaaagagct 960 gtatcagcac ttcaaagcaa gggtgtacaa gctcaaatgg ctagacaaca agagcaggat 1020 ccaacaaatc tctatttatc aaatttaccc aaatccatag atgagaatca attacaacag 1080 atgctatcta cgtatggacg tgttatatca gttagaatat taaaagatgc agctagctat 1140 agcaaaggag ttggctttgc tagaatggaa agtaaagaaa tttgccaaac tgtgatagga 1200 aaactatgcg gccagcatat cctaggcagc ccagaaccgt tgttagtcaa atttgccgat 1260 ggaggcccga agaaacggac gcagcaccaa gataaagtat ggcaggacaa cgagggagct 1320 tatctggctg cctatgaaat agctaatacc actggatcgt cagttaataa cactggttca 1380 tcaagagtaa cagcagtaat gccgggacaa atggtttcat acactcaagg gtccagtgga 1440 agccattatc agcaacaacc tgtgacagcc agtgttggct gggttccttc tcaaccatac 1500 gcagtagctg ttagcccaca tgttcccttg agtccaacat cggtagaacc acacagtatt 1560 gcgcatgtgc agcagaatgt catgcctcat ttaaccaatc aaatggctca tatgcagtta 1620 ccaagtggcg gatatttgac ttcagtacca acagtggctg gttatgccgc tcaaaacaat 1680 tggcacgtat cacagccaca cacccagtca catcatggac aaattgatga atctcacttc 1740 atagtaggca gtccacctga aaaccaagat ggttcaattt cacacgtgca tggaacgtca 1800 ggccatcaca tgcaacagca tccaaacgag gccatcatag atgatcatca tcgcgttgtt 1860 tacacgactt atccaagaaa aggatag 1887 <210> 83 <211> 1887 <212> DNA <213> Artificial Sequence <220> <223> RNA-binding motif, single-stranded-interacting protein 1-like-2 <400> 83 atggttagtg taagaagtaa tgaagagaag caccaaagat tggacggagc aaaacgagtg 60 gataccgtgc gttcatcaaa ggatccttcg tcaacatcat ccgtagccat tagtagcctg 120 aagcctgcaa acgaagctac gaatgaaatc aatggactga caaataatca caattgcgaa 180 gacgacgaat ctttgacaac atccactact agcattacat caagtattga tcaaaacaca 240 cactctcctg tttcttcacc tcctgcctct gcaaccaacg gtaattcgaa catgagtgac 300 tcacaaaata atagtgacat tgaggcgaag gtgtccaatg gcccaaacag cagttccgtg 360 gacagcgatg tggacaccgc cgatatcggt gatgttgatg attgtgattc ggacattaga 420 aagaaaccga tttcctcgca accacaacca aagagaataa taaccagaga aaagaaacct 480 gaagatcgta aacagacaag aagccagtca ccaaaaggca cctacggtag atcagtgaga 540 cccggcctcg ttcagccgat ggtgtggcca gcctcgaacc tgccccaaaa ctgggcacaa 600 ttcagcggat atcactaccc gggacaagca aggatgcctg caccaatggc tctcataact 660 ccatatgcac cggcttacat gccgatgtct ggtgggagag atggtcgagt gggccagtca 720 ccgactcatt cgggaagcaa ttacatgact tcacattcgc ctcacgcggg cgaaaaactc 780 agcaaaacta atttgtacat aagaggactt atgccaaaca cagctgatga ggacttagtt 840 gtcatgtgcc aacagtacgg aacaatcatt tctacgaaag ctattttaga taaagataca 900 aataagtgca aaggttatgg ctttgttgac tttgacagcc cttattcagc ccaaagagct 960 gtatcagcac ttcaaagcaa gggtgtacaa gctcaaatgg ctagacaaca agagcaggat 1020 ccaacaaatc tctatttatc aaatttaccc aaatccatag atgagaatca attacaacag 1080 atgctatcta cgtatggacg tgttatatca gttagaatat taaaagatgc agctagctat 1140 agcaaaggag ttggctttgc tagaatggaa agtaaagaaa tttgccaaac tgtgatagga 1200 aaactatgcg gccagcatat cctaggcagc ccagaaccgt tgttagtcaa atttgccgat 1260 ggaggcccga agaaacggac gcagcaccaa gataaagtat ggcaggacaa cgagggagct 1320 tatctggctg cctatgaaat agctaatacc actggatcgt cagttaataa cactggttca 1380 tcaagagtaa cagcagtaat gccgggacaa atggtttcat acactcaagg gtccagtgga 1440 agccattatc agcaacaacc tgtgacagcc agtgttggct gggttccttc tcaaccatac 1500 gcagtagctg ttagcccaca tgttcccttg agtccaacat cggtagaacc acacagtatt 1560 gcgcatgtgc agcagaatgt catgcctcat ttaaccaatc aaatggctca tatgcagtta 1620 ccaagtggcg gatatttgac ttcagtacca acagtggctg gttatgccgc tcaaaacaat 1680 tggcacgtat cacagccaca cacccagtca catcatggac aaattgatga atctcacttc 1740 atagtaggca gtccacctga aaaccaagat ggttcaattt cacacgtgca tggaacgtca 1800 ggccatcaca tgcaacagca tccaaacgag gccatcatag atgatcatca tcgcgttgtt 1860 tacacgactt atccaagaaa aggatag 1887 <210> 84 <211> 693 <212> DNA <213> Artificial Sequence <220> <223> roundabout <400> 84 atgtttttac acttgcaaaa tttaaaagtc tccagaatgg cgttgcaata tttatatgct 60 ctttgctgta tattactact tgagatcact gctggactac cttcgagaac aatatttggt 120 gtgacaaatc tcattgccgt ggccggtaaa gacaatcgga ttctactctc ttgtccactg 180 tccgtatata tacccgtgac ttggataaaa gatggaaccg aaatcaagcc aacgagcacg 240 aacagataca ttatctcagg aggcaacctt gtcgtatcaa acgtagactt gaacgacgaa 300 ggaagatatg tttgcaaatc gaagttctac gacggatctg tttttaaagc aactttcaaa 360 gtcacgatta acaaattacc gagtataatt gataaacaaa gacaaaggcg gtggtgcgag 420 ttgggaagca cggtgataat gagatgcaag gccacaggga aaccaaaacc ggacgtattt 480 tggataaacg aagatggtta ctcgccaatc agccctccaa aagtcactca gatatccgcg 540 agtacgctaa gaatcaacga cattcgtgaa tctgactcta gaacgctaat atgcatagca 600 cagaatatac atggacgggc aagagcaaga ttcagcatct tcattagaaa atcttctaaa 660 aacatcacct catcaacata cacaaaaaaa taa 693 <210> 85 <211> 1563 <212> DNA <213> Artificial Sequence <220> <223> serine protease 56-like <400> 85 atgaagctgc tattgacctt attgtatgga ataatctggc tgcaacaatt aacaggcgat 60 gtgtcggcag cagtttgcca agacagccac caacactgtc gcagttgggc ttcgaggaac 120 caatgcgcta caaaccctgg atacatgaac gtctactgtc gcaaaagctg caaccgatgc 180 gtcacaacat acgttgcatc atctccacgt agagtgtatt cgtcaagaca gacatgcgca 240 gatagctcga gcaactgccc gtactgggca cggacaagac aatgcagcct caaccctggt 300 tacatgctta aattttgcag gaaaagctgc aacaattgcc cacgggccac gaccacatac 360 acatcaaggc gcacaagcca atgcagagac tatgaaactc aaacgaaatg cgcctactgg 420 agacgcaggg gctattgcta tcaacgcaac tcttattatc aatttatgaa gcagaaatgc 480 agcaaaacat gcggattctg cagagtggca gctaccaggc ctaaacccaa gcccaagcca 540 agaccaagac caacgtcacg acgaaaatca agacgaaagt caaggccaag accaaagcca 600 aagccaagac caagaccaaa accaaagcca aagccaaaga aaaagcatcc acatccacat 660 cctaagccaa aaccaaaacc aaagccgcag cctaagccta agccaacgcc agaaccgaga 720 ccaccgcgac cgagaccacc gcgacctacg tctgagccga taccgccacg tccaattcca 780 ccaacacata ctaaaataaa cagcttattc tgtggattgc gcttaaaagg tcgcgttatt 840 ggaggcgaga acgctatgag cggcgactgg ccttggaccg tagcccttgc gagaaaagtg 900 aaaccaaaga gtcccttctg cggaggagtg cttattaata gacaatgggt tcttactgca 960 agtcactgtt ttggaaatgc aaactcaaga agagtcaagc cagaacatat cgttgttcga 1020 tgcgccgaac acgatctaaa aacctcagaa cctggagaag tggtggttga cgtcatcaag 1080 ataattcgtc acaacggctt tgtacgaggc tcattcaaca atgatattgc gttggtaaag 1140 ctggcgaaac ctgtcaaata caaccaactc atcaaaccga tctgccttcc cgccaaaaac 1200 aaagagctca gacccagtac ccaaagctac gtggtcgggt ggggaagact acacttcctc 1260 ggtcaaagag cacatattct acaagaggca aggattccca ttgttgcgca accaacatgc 1320 tggaaaacat taagcaaggt tggtacctac acaaacaaca tgatatgcgc aggatacaag 1380 aaaggaggag ttgatgcctg tcgaggagac agtggtggtc cgttggtgta cagaagtggt 1440 ggtcgcttcg aactggctgg cattgtaagc tggggaagtg gctgtggaga tgctggcaaa 1500 tatggcgtct acactaaagt cagcaaatac atagattggg tgaaagcaaa tataagaaac 1560 tag 1563 <210> 86 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> serine/threonine-protein kinase 32B-like <400> 86 atgcaactgt ttactcctca gaggccgttt gaaatatatt cggagacgcc tgtgaaagac 60 gcgtacgaaa tattcacgtc tgagcttgtt cttgagttgc caaacagcat ttcagatgat 120 acggttcgat tgataaaaaa actgctgcaa ccacatccga gaaagcgcct gtgcaggctc 180 gacgcactga aggcacacgt atccatggaa ggtatcgatt ttgaaagcgt aaagagaaaa 240 gaatgtctca tgagttttgt accttcggtg agcttattta ttgtctctct tttcaatgtg 300 ttgtctgtct atctttggtt cttgtga 327 <210> 87 <211> 906 <212> DNA <213> Artificial Sequence <220> <223> snurportin 1 <400> 87 tcttatctgg actacgtgag gtgtgaaaag caagttgtat ctagaagttt tgatgttcat 60 gttacatgtt catgtttcat gttacacatc aaaatggagg atagcttcct tgctacgttt 120 tcaatagatt tgaaactaac atcagaagaa aatgacacaa ccataacaca cccaaggttt 180 tcagatttta agcagacgaa gcaagcaaaa agatgcgatc aagaacatag gagagcaaaa 240 atgattgaaa gacaaaagtc aaaaagatat gattgtgtga actatgcaag aaaacttgtt 300 gatggggagc tcacagaaaa tgatattgaa gtagatggag atgaacagat gaaggaacat 360 tctacagaaa aaaagtttaa tcctttcaaa aaccagctca tgctatcaga atggctggta 420 gatgtaccat cagatcttgt tgagcaatgg acaatgactg tgtgccctct tggaaaacga 480 tgcctagttg tggcaaacag ggggtcaaca tctgtgtaca caaaaagtgg atattgcgtg 540 aacagatttc cttctctatt gcccggtggc tgcaaacaaa ctcttaaacc aggagagtac 600 actgttcttg actgcatcta cagcgaagtt tctcacacgt tttacataat cgacctgaca 660 tgctggagag gacacccagt gtacgacagt gagactgagt tcagaatgta ttggttgaag 720 acaaagcttg aagatgaaga agatttaaaa cagaaatcgc gtcttaatcc atatgttttc 780 atacaagctc ctgtttttgg ctgttcagtc gctgaaatag aacaagctct gtcaagtaca 840 tatcctttcc aggttgacgg tgtattattc taccacaaaa gagctcatta ttctccagcc 900 acttga 906 <210> 88 <211> 2145 <212> DNA <213> Artificial Sequence <220> <223> soluble guanylate cyclase 88E <400> 88 atgtatggct tgatattcca caatctacag acggctctga ttgagagatt cggtcaagat 60 acgtatgcag agattcgaaa gctcgcgggc ctagaagaac atgtattttg cgtacataaa 120 cagtattctg atgatatact gatgcgaatt gttgactcag cagccgaagt gacaaaatgc 180 agcaaagatg aaattctaca tgacatgggt agacattttc cccgcttttg tggagaatcc 240 ggctactaca aaatcatgaa aacagtcggt agaaatctga aagagttcct taacggtttg 300 gatcacatgc atgaatgcct gcgctactcg tatccaggca tgcgctcacc aagcttctac 360 tgcgatcagg aaaccgaatc cggattaaga ttgcactatc ggtcgaagcg acgtggttat 420 attaagtacg tgcaaggaca gatcgaagaa atcgctagtt atctgttcaa tatcacggct 480 acagtggagc tggaaagttt agaggatgat cccgaagggg atcatgccat tctgaaaatc 540 ctcttcaaga ataccgtgga aaaacgaaaa acttcaacag gaatggacag agtttgtcca 600 atggtttcaa ctaacttgat atttcagatg tttccatttc atttgatgtt tcaacgtgat 660 ttggttgtgt ttggtgtcgg gaattctctc ttcaaaattt tgcctcacat aagcgggcgt 720 gtcttgacag attgcttcca actccatcgt cctgtaattg cactaacatg gaataacatc 780 gttgatcacc cgaactgtgt ttttgaatta atcacaaaca cttcaaactc gccaaaaaga 840 aataaattta acaaaatgga ggatattgga aatgatttgt cttcaaatcg acttcactta 900 aaaggacaaa tgatgttcat tgaacattgg aaagcattta tttatttagc atcacctgtg 960 cttgaagatt tagacgatat gtacaatgta ggattatatt tgaatgattt ttgcatccat 1020 gacgcctctc gtgatcttgt tctcattgga aatcagaagt ctgccgaact caaattggca 1080 ttagatcagg agctggagaa aagtgcagag ctcgaggaga gtatgaaaaa gctggaccag 1140 gagatgcaaa aaactgacaa gcttctgtac agcatgatac caaaaactgt tgcaaaccga 1200 ctcagaaaag gcgatttggc agtcaacaca tgcgagcatt ttgacaatgt ctcgatatta 1260 ttcagtgatg tggttggctt tacaacgatc tgttcaaaga ttacaccaat ggaggttgta 1320 gacatgttaa actgcatgta cacctctttc gatactctca gtgaggaaaa tagtgtctac 1380 aaggtagaaa cgataggcga tgcgtacatg gtggtcagcg gtgttccgga gagaatccac 1440 aaccatgcgc aaagaatcgc tgacatggcg tttgcaatgt tgaaatccgt gacgggaata 1500 aaaaacccgt ccaatccaaa acacaatttg caaattagaa tcggcatcca ttccggcagt 1560 gttgtggccg gagttgtggg tatcaaaatg ccaagatact gcttatttgg agatacagtt 1620 aataccgcat ccagaatgga agctaactca gtcgcaatgt caatacacat cagtgaaacg 1680 acaaaaaatg agcttgatga aggaaattac gtcatcagga gaagaggggc tgtgcaaatt 1740 aaaggcaaag gaatgatgaa tagttattgg ctaattggac aagggagttc atctcaagca 1800 ttgtcagcga tgtctgttcg atcgattgaa gatgccgatg tggaggagat cgtaacagga 1860 gataacgaca cacttataga cgaatcaatg atgaagtccc tgagttataa agcagataaa 1920 agtagaaatg ccataagaat gcgacccagc gctaaaccaa tactgggatt gccaaatgat 1980 atgaatggtg atacgaagaa cgtgcctgag gcaccaagcc attactcgaa tttgagccat 2040 gatgacgaca cacttttagc aaagagtaag ttgaagttga ctaaaaaaaa gtccataaat 2100 ggaagtccgg gtagtgaaaa gagcttagta tgcatcatac tatga 2145 <210> 89 <211> 981 <212> DNA <213> Artificial Sequence <220> <223> spermidine synthase-like-1 <400> 89 atgggttcct atatcaaaga tggtgtattc tacgaagagg tgtatgacaa tgttccgttt 60 gagaatctga cagggattac cgtggatcga gtactttatc gaggcaggtc aaagtatcaa 120 gatattcttg tatttgacag tgcaacaagc ggtagaattt tggtccttga tggactcata 180 caacttacag ctaaagacga attcgcgtat catgaaactc tctcattcac agcactggct 240 tcccataaag acccaaaaaa ggttttgatc gttggtggtg gcgatggtgg catggcacga 300 gaggccgcca aatttccaag cgtcgagtcc ataaccattt gtgaaatcga tgaggaagtt 360 gtgaacactt gcaaaaagtt gtttcccaag ctatcgaaaa gcttcagcaa tccgaaagtc 420 aacctggtca tcgaagatgc attcgagtat ttgaagaata aaaataacga atatgatgta 480 atcatttctg attctacaga cccgaacaga gacgatggag catcgtgtct ttttacaaat 540 gaattctacg caatggtaaa gacatcattg aaaccaaacg ggatatttct atcacaaact 600 ggtaacaaca tgtggagacc acagctgaaa ggcctgcaaa tacaatcggg gaagcatttc 660 accatggtga aattcggatt tgtctcagtt ccctgttacg acgttggtca aaatggcttt 720 gtaatttgca gcgacgaaga tgaaaaagca agcaacagag taaccagccc atattggaag 780 ttttcggatg aagagatcga tagaatggac ctaaagttct acaactcgca aattcatcaa 840 tactcctttg tattacccac atttttgaaa aagtatctcg aggagtctat gagtgaaaag 900 gtggacgtag tggaatggat tgaatcaagg aaaacgaagc aaaatgcaaa tgaaatcata 960 gcaaatgggt acaaccatta a 981 <210> 90 <211> 972 <212> DNA <213> Artificial Sequence <220> <223> spermidine synthase-like-2 <400> 90 atgggttcct atatcaaaga tggtgtattc tacgaagagg tgtatgacaa tgttccgttt 60 gagaatctga cagggattac cgtggatcga gtactttatc gaggcaggtc aaagtatcaa 120 gatattcttg tatttgacag tgcaacaagc ggtagaattt tggtccttga tggactcata 180 caacttacag ctaaagacga attcgcgtat catgaaactc tctcattcac agcactggct 240 tcccataaag acccaaaaaa ggttttgatc gttggtggtg gcgatggtgg catggcacga 300 gaggccgcca aatttccaag cgtcgagtcc ataaccattt gtgaaatcga tgaggaagtt 360 gtgaacactt gcaaaaagtt gtttcccaag ctatcgaaaa gcttcagcaa tccgaaagtc 420 aacctggtca tcgaagatgc attcgagtat ttgaagaata aaaataacga atatgatgta 480 atcatttctg attctacaga cccgaacaga gacgatggag catcgtgtct ttttacaaat 540 gaattctacg caatggtaaa gacatcattg aaaccaaacg ggatatttct atcacaaact 600 ggtaacaaca tgtggagacc acagctgaaa ggcctgcaaa tacaatcggg gaagcatttc 660 accatggtga aattcggatt tgtctcagtt ccctgttacg acgttggtca aaatggcttt 720 gtaatttgca gcgacgaaga tgaaaaaaga gtaaccagcc catattggaa gttttcggat 780 gaagagatcg atagaatgga cctaaagttc tacaactcgc aaattcatca atactccttt 840 gtattaccca catttttgaa aaagtatctc gaggagtcta tgagtgaaaa ggtggacgta 900 gtggaatgga ttgaatcaag gaaaacgaag caaaatgcaa atgaaatcat agcaaatggg 960 tacaaccatt aa 972 <210> 91 <211> 345 <212> DNA <213> Artificial Sequence <220> <223> spore coat protein SP65-like <400> 91 atgagagtca caaacgaaca gttgttgtca atgctcaagg agaagtctgt cagactggtg 60 gatgtgagaa gtccatggga aattgaaaac gaaggcaaaa tctccgggtc tgtcaatata 120 ccgttgaatg aacttgagac tgccttgtct atgccggagg aacaattcca tgggaaattc 180 aagatgcaaa agccgaaaaa agacgactgc aatttggtat tccactgcaa aggtggtggt 240 agaagcttaa aagctgtcac cttggcaaga gaaatgggat ggcattgctc tcgtcatctt 300 gttggaggct ttgaaggttg gaagaagctt ggagccaaaa actga 345 <210> 92 <211> 396 <212> DNA <213> Artificial Sequence <220> <223> SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) <400> 92 atgtataaag aattgctcaa aaaagatcct tatttatata cgcaaaatgg aattctgcac 60 atgttagaca gaaaccgtcg aataaagaag agacccgaaa agtttcaaac ttgtacagat 120 gaatttgaca ttgtcataac ttgcgaagaa cgtgtttatg accaagtaat tgaagagatg 180 agcaagagag agccatcgaa ttacacccca gttcatatta tcaacattga catagctgat 240 aatcacgaag aggcgacact cggagctttg cttatattag aactttgcga cattcttgat 300 gaacttgacg acatggaaca taacattgac gaaattctgc aagcatacga gcagaaaatc 360 gatcgccaca tatttcatac cgttgcgttc tattga 396 <210> 93 <211> 687 <212> DNA <213> Artificial Sequence <220> <223> stromelysin-3-like <400> 93 atggctctct tcatgcaagg agttctacta agtctggctg tactattcac tggcaataac 60 tttaatctag tcttaggggt acctgtacca aatgtagctg atgcatctag gcacgaaagt 120 attgcatctg aattgaaaaa caaaacaaca gaaaagaaag gagcggcaaa atatttcctg 180 aaatatggat atctgcagga tttttccgat tctgccaatg aaaaggtatt tgctgaaagc 240 ataaaaaagt tccaaagatt tgctgggttg aaggccacag gaaaacttga taaagctacg 300 aagaagcaat ttacaattcc gaggtgtgga ttacaagatc cgatattaaa actgtccggt 360 cgcaagagga gatatcttct tcagggaagc aagtgggatt tgagcaagca tcctggaaga 420 acattgacat ggaatcttga gaacacaggc caatacttaa agaaagaaga cgtcagacgc 480 gttatgaggc aagcattttc aatatggcag aaacacgcaa acatcttctt caaggaggaa 540 accaaatcca atgttgatat caaagttaaa tttgcaaatg gttgccacgg agatccatat 600 tgctttgact tcagaggtgg cacattggcg catgcgttct atccatatcc aggtcaagat 660 atatctggag acgtccattt tgataat 687 <210> 94 <211> 306 <212> DNA <213> Artificial Sequence <220> <223> techylectin-5B-like <400> 94 acaaatggcg gtggaaagtg gatgcttcgt gttgatctta agtcttctga tggagaccaa 60 ggctacgcaa aatacaccaa ctttaacatt gcctccgcac aagaaaacta taaactgaca 120 tatggaactt attcgggaaa tgttggagac gcaatgttga gatcgaacgg ttctgcattt 180 tcaacttatg ataaagacaa cgataatacc caattcatcc attgtgcaca atcttaccaa 240 gggggatggt ggcattcttc gtgctttgat gcaatgttga ataatcgtta ccctggcaca 300 ggaaca 306 <210> 95 <211> 3231 <212> DNA <213> Artificial Sequence <220> <223> tetratricopeptide repeat domain 34 <400> 95 atggagcata aagcacgaaa atattgcaag ctgtacagag caaaaccggc gcatgcaata 60 gcacgcatgt acaaagagct ttcgcaaaac ataatcaatg gcctaagtgt tctgttgacc 120 gattggtgct cctacgcagc agaaaacgac gcagcggcgc gtttggatct tttgattcct 180 ctcgactggc aacagctcta cgatttcaca tcagagctgc tctcgtacga atcgaacgaa 240 acgctgacca tagccaaagc cgtacgcgtc ttaaagaacc agcatgcaac tatgacgtca 300 ctggtaagtt tggcacaagt tctgcgcgca tgcgaaacga ggagtgtgga tagtctcgtt 360 ctgatgtcga caataaacgc acgggtcgga aaagacagtg aatgcttgag gtatctcagc 420 atggcattag aatgcagtag gaatcttggt gctgcgtgtt tgaggtctcg gctgtatcta 480 ctgtcagttg cagatttgga gctgttgaaa ctgacgattg aaagcaatcg taggcagtgt 540 aatattggca cagggaatca aggctacaac agagaagatt cttttgagtt ttttgttgaa 600 gacggtgcca accacataga agaagcggtg gccaaacatt cagccacaac gtccctgccc 660 aaaactgaaa taaaaaagaa agctgatgcg actcaggcgg gtttggcaaa atcgcaacta 720 gattcgattt acgacgaagt gaatcaagcg ttgtcgcact taacagaaat agacgtgttt 780 ttagattcga taatccaggc acacttggac gctaacagac cgtacgtcgc tgtatggttg 840 tcgctggatt gtttaaacga gaagcaacag ctaccaagga taaaacgttg cgtttcagag 900 caactacacg cgtttgttct gaccgtgata agcgacatgt tggaaataat caagcaaaaa 960 gacgtccaag aggaattatc atcggatttg atgaggggat ttcgagaaag aacggtcaga 1020 tattccaagc ttgctttgtg tttaatggga acaaaagatg acgacaaaac aaacctgctt 1080 tatttgaaat gtcttcacca aaatcaacag atttccgaag cgctgaaaac cgcacaaaaa 1140 ttactccaag gctcgaacat tgttaccgat aataggacaa gtgaaatatt gcgaatagtg 1200 gcctattgta agatattctt gagtcaatac gaggaagcac ttgatgtaat cgacactatc 1260 gccgcttcga gtaaaggttg cgtggaattg tggtgtgttc gcggtttcgc gttgtgtctc 1320 gcggacaagc tggagcaagg tatatgtgac gtaatgtgcg catgcacaaa tggactttcg 1380 acaactgttt tgaatttccg gagcttcaag caagccgacc aggagaaaat tcggtataat 1440 attactgaat atatcaaaga gaaaattgca tcagaataca caaagggatg tcgagctcaa 1500 attaaggaac catgtaacat taatagtgtc gggtgctgct gtaatcgaaa atcagaaaaa 1560 aatgctcagg atttggtgac gttttgcgaa tttcttacga ccctttacaa aggagacctt 1620 aaattacacc tgctgtttgt cgatgttctg ttacgtatgc aaagatacag tgaagctcag 1680 aaaactcttg ttctattcat taagagtgtc ccggatgatc ctctacccat gattcacctc 1740 gcaaacatac gcatgcgcct cggagcatac gttgctgccg tggatgattt gcgagtgatt 1800 atgcgggcgt tgggttgcgc gaagttttca acttacatga cacatctgtg cgctgaagat 1860 cgacatgaca tcgccagggt gcttcgcaag catgctttcc aacacttgca acatcaacgc 1920 tacgcagatg caatcgaatg tttcaacatc gcgataatcg caattcgtga cgtcacaaca 1980 acgacaacgg cagcgacagg acttgttttg gtgcgcgcat tttctttcgc taatcttgga 2040 gactacgagc tggcgttgac ggatttcaac accgtactgg acgcggagcc ggggaatttt 2100 gccgcgcggc tcggtagtgc ggtcgtgtat gcggtcctaa actacgacga agagtgtgtg 2160 gagagcgtgt cgcaagtgct gtgcgatgac acaaacttgg ctgttcaagt attggaaaaa 2220 ctgtctttga attgcgtcgt gcggtttacg tcgactatcg agagctacat acgtcaacag 2280 ttagaaattt atgtaccgga tgcggtggcc caaaaacccc acggcgcaga aatagcggtg 2340 gagcaaaatc aaagtgatga cgaatacgat aatgaaaacg atgaaatatt aaatagagta 2400 ggcagttata ttgaatttct cggtcaactg catcagaaat caaccgagtt catttccctc 2460 cacgcacagt acttgatcat gcgtggcgac tacgaaggcg ctttggagca gattagcctc 2520 ggtttgagac tggcctcgga tgacagtcgt ttgttgtcaa agaaaggatt agtcaaaatg 2580 aaaatgtcaa aactccaaga agcaatggat atttggaagg agatagcagt agataaggac 2640 gatggtggta gagacaagaa attagtaaaa aatacaataa aaaagctcac tattgacgaa 2700 cgcactgaaa ttccacgcga agctgttcgt tgtgctgacc acctttgcga cgaagcgaac 2760 tacaaagaag cgaacaagta ttacggcctg gcactagttg cagcggaaaa cgatagttca 2820 gatattgaca tattacgtag caggtttgta tgcttgctga atgatggcct agttcaggcg 2880 gcactgaacg acatatctgt cgtgatagag aagaaaccaa aatataacga ctactgcaaa 2940 agagcgaagc ttttagacga tatgggaaaa cagaaggcag cctgttctga ttttataatg 3000 gcattggaga tggatgagga gaatactgtt gcgtttttgg tcgatgaggc gttgttgaaa 3060 catgttttgt gcatgttttg ctctgcttca agcagtgctt tcgtacaaga acagcaccaa 3120 gacgtgctaa agtattgcga atacggactg aaacttgatc cgaaccacaa gggcatgaaa 3180 cagctaagat atcgatctaa atgtatcatg aacaaatgca ctgtgcaata a 3231 <210> 96 <211> 2154 <212> DNA <213> Artificial Sequence <220> <223> threonine--tRNA ligase, cytoplasmic <400> 96 atggctgctc cttctgaaga gctctcaaaa atggacctga aagacgaaaa gccccaaaag 60 gcaccctcca agaaaaaggc agataagaaa tctaaggata aaccaactgc tactggtcat 120 cctgttgagt taaaccctcc tccaacatat ctggaagata gaatcaaact gtttgacaaa 180 ctgaaagtag aatatgatgc tgaaattgca gcaaaagaac gattgccaat caaagtcact 240 ttgccagatg gaaaggaagt tgatggaacg tcatgggaaa caacaccata tcaagttgca 300 gcatctataa gccaaggtct tgctgacaac tgcattgttg caaaggtgaa tggaatagtg 360 tgggatcttg acagaccatt tgaatgtagc agctccctgc aactgttgaa gtttgatgac 420 aaagaagctc aaactgtgta ctggcattca actgctcatg ttcttggtga agcaatggag 480 cgacattacg gtgggtgtct ttgctatgga cccccgattg aagaagggtt cttttatgat 540 atgtacttag aaggcaggca agtgtcaaca accgatttca cacctcttga aacaataatc 600 aaatcagcga taaaagagaa acagccattt gaaaggctcg aaatgaagat agaagacttg 660 ctgaaaatgt ttgagtataa cgagttcaaa tgtcgaattt tgagggagag agtcaagaca 720 ccaacgacca cagtttatcg ctgtggtcct ttgattgatc tgtgcagagg accacatgtt 780 agacacactg gcaaaatcaa gtcagttgcc ttgaccaaga attcagcaac ctattgggag 840 ggaaactgtg aagcagaatc gttacagaga gtttatggca tatcatttcc cagtgagaag 900 caaatgaaag aatggaaaca tttccaacaa gaagctgcca aacgagatca cagaaagatt 960 ggaagagatc aagagctgtt tttcttcaat gacgtcagtc ctggaagttg tttctttcag 1020 ccgaacggtg cctacattta caacaccctt gttgatttta tcaagacgga atacaagaag 1080 agagggttca aggaagtcat tactccgaat atctacagca caaaattatg ggagacatcc 1140 gggcattggc aacattattc aaccaacatg tttagttttg atgttgaaaa ggagacctat 1200 gctttgaagc caatgaattg cccagggcat tgtatgatgt ttgaccatcg tccccgctcg 1260 tggcgtgagc tgccgctgag aatggcggat ttcggtgtgc tgcacagaaa cgagctgtcc 1320 ggagcattga ccggtctcac aagagtgcga aggttccagc aagacgatgc gcacatcttt 1380 tgcaccatgg aacaagttcg tgaagaaatg aaaggttgtt tggatttttt gcaagctgtt 1440 tactctgtct ttggattccg atttaagctg tttctttcca ctcgtcctga gaagtacatc 1500 ggggatattg acaattggaa caaatctgag aaggaacttg agaatgcttt aaacgatttt 1560 ggacataaat gggaaatgaa ccctggcgat ggtgcatttt atgggcccaa gattgatatt 1620 caaatccaag atgcgttgag gagatatcac caatgtgcaa ccattcaact ggacttcaat 1680 cttcccgaaa gattcaagct cacatacgtc agtggggatg gtgacgagag gaaaagacct 1740 gttattattc acagggccat tcttgggtcc gtggaaagaa tgatagccat tctcactgaa 1800 agttatggtg gtaaatggcc gttctggtta tcaccacgcc aagctattgt catcccggtc 1860 aatccaaaat acgatgaata tgcaatgaag gtttgcaaga ggatacaaga tgaagatttc 1920 atgattgaag tcaatcttga ccacggtgaa acgttgaaca agaagatcag aaatgcacag 1980 ttggctcaat ataatttcat acttgttgtt ggcgaaaagg aacaggatgc cgacaccgtt 2040 aacgtgcgaa cccgagacaa caaggtacac ggagagaaac acgtcactgc agtcatcgag 2100 cagttcaata ttttgaagaa aggaaaaatc gcagacagcg aagagtcatt ttaa 2154 <210> 97 <211> 2286 <212> DNA <213> Artificial Sequence <220> <223> Tight junction protein ZO-3-1 <400> 97 agagcataca caaagtgtag tgcagtactt tcacgagcga agatgtatgg aagaattttg 60 atttcagtaa taatttctgg ctatttagtt ggattttgca caagcctaac tatcgtaaga 120 aattgcacat ttccaggttt atgcgacgat caagaaagtg agaaagaaaa cattgaaata 180 cgtttggaaa atagaacatc tgtgcaacca gtgattatcc atgccaagaa aaagatttcc 240 acatttactc ccattgtgcc gcgattaaat gaggatgtag cagcacaaac aggaaagtct 300 ttgcaataca gccttatcat agcactgctg gcaacattat tggtgacttc gatggctgca 360 ataaccctac tgcttttacg tcacaacata caatttaaaa gaatgacttt gagtcaaatg 420 gaaacaggca aaagagacag tggagacaca aatacacaaa gtactaaagc tcacctaaaa 480 acattaatac ttgatgacac tgagttttta gggaaggcag agtcatgtta tttcgaagac 540 acagttgact gcattgctga tcgcccatac aattgcaaca aaactgaaaa attcaacaac 600 tcttcaggtc aagatgaagt attttactgt atgctttcaa atagtcttga taagcagcac 660 tttgatacca caaggaacat cctgggaaag caaagattaa ttaaatccaa agcacaggtt 720 ttgaggatga acttgacaga aaatcttatg caaaaaattg acaacaaaga aaatctcaag 780 tgcttagaga gtgaagagca cctttcgtca ccagatcctg ttgaaaatgt tgatgaagtg 840 atagatatgt cgatggtgga tggagatgat catgtcacaa caaagcaact tgaaagtgat 900 gattatgaag ttgattgctt gtcaagacga gataccggct tttcttcact gttggataac 960 agtgacacaa tcattttgga gacacgtgca aagattggac cacgcggagg gcagttaaag 1020 gttgaaggtt catctgttat tgtcaatgtt ccaaaaggtg ctatagttgg aaaggagcaa 1080 gaactatccc ttaaggtcta cctcgggcca ccaaacgatc accaagagct ggagagactt 1140 gggcatactg ttgaacttcc ccttgtggag ctgggaccga gtgggttgcg attcaaccgg 1200 ccggtcgaag tggtcacaca gaacagctcg gtcgacccag acgatgccga tgatgaagat 1260 gacggaatcg actttgaata tgctgatggc atgttcaagc cagacactgt gtggaagaag 1320 gccctgcggg ggagcaccag agaggaatcc atagcgttgg ccgttgaaaa agaaccccat 1380 gtcagctttt ttgtaaccag tgcccaaacc tgcgcatact acatgcattt tacgctcggc 1440 cgtaaattgc tgaaacgacc ttccaggaag aatctggcgg cgtgtgtata tgcagacggc 1500 aagcatgttc aggtcagtgg ttgtctccga ctgggcatct tcttttatga gaattcagag 1560 gaaggagaaa cgattttgca aaggaataca agtggtatgg aaaaagttgc acttccaaaa 1620 ccattctcgg tgcgaaaggg agcttctacg agagtgcaaa tgcagaactt aactgatggc 1680 tggagcctga agcaaggaca caacgagcag gaggtttctc tggaaaattt ctttcaagcg 1740 tcgaaacttg gcaaactgtc gacaactgat tacataattg aaaacgaaga gaatcccagc 1800 tctctcttta catgtttgtt cgatctgcac caagataaca acaagctggc cgatttaata 1860 gtcatgggac gtataattgg aaggcaatac tccgtttcat ctggttacaa ttctgatgcg 1920 tcgtcttttc aagcagagga ggaatcgtac cacatcacag aaccagatgt tcccaagact 1980 gatcctcgta aatatatgaa taggataatt catcaactat ccacactcgc tgctccgaac 2040 tacaaagcaa tctgcagaaa cctgggaatt tcggagattg caatcgacac agccgaaatg 2100 gaccgtggtc gcgaaggatg ctatgaagtc tgctgccaac ttctgctgca atggcttcgc 2160 aatcacgatg atgggggaca tttaatagag actgcgatga atgagctcaa atcagctgtg 2220 gatagaacca agcttcatta taccattcat tttccaagag ttagagcgag agagaccatt 2280 gtttaa 2286 <210> 98 <211> 2217 <212> DNA <213> Artificial Sequence <220> <223> Tight junction protein ZO-3-2 <400> 98 ataatttctg gctatttagt tggattttgc acaagcctaa ctatcgtaag aaattgcaca 60 tttccaggtt tatgcgacga tcaagaaagt gagaaagaaa acattgaaat acgtttggaa 120 aatagaacat ctgtgcaacc agtgattatc catgccaaga aaaagatttc cacatttact 180 cccattgtgc cgcgattaaa tgaggatgta gcagcacaaa caggaaagtc tttgcaatac 240 agccttatca tagcactgct ggcaacatta ttggtgactt cgatggctgc aataacccta 300 ctgcttttac gtcacaacat acaatttaaa agaatgactt tgagtcaaat ggaaacaggc 360 aaaagagaca gtggagacac aaatacacaa agtactaaag ctcacctaaa aacattaata 420 cttgatgaca ctgagttttt agggaaggca gagtcatgtt atttcgaaga cacagttgac 480 tgcattgctg atcgcccata caattgcaac aaaactgaaa aattcaacaa ctcttcaggt 540 caagatgaag tattttactg tatgctttca aatagtcttg ataagcagca ctttgatacc 600 acaaggaaca tcctgggaaa gcaaagatta attaaatcca aagcacaggt tttgaggatg 660 aacttgacag aaaatcttat gcaaaaaatt gacaacaaag aaaatctcaa gtgcttagag 720 agtgaagagc acctttcgtc accagatcct gttgaaaatg ttgatgaagt gatagatatg 780 tcgatggtgg atggagatga tcatgtcaca acaaagcaac ttgaaagtga tgattatgaa 840 gttgattgct tgtcaagacg agataccggc ttttcttcac tgttggataa cagtgacaca 900 atcattttgg agacacgtgc aaagattgga ccacgcggag ggcagttaaa ggttgaaggt 960 tcatctgtta ttgtcaatgt tccaaaaggt gctatagttg gaaaggagca agaactatcc 1020 cttaaggtct acctcgggcc accaaacgat caccaagagc tggagagact tgggcatact 1080 gttgaacttc cccttgtgga gctgggaccg agtgggttgc gattcaaccg gccggtcgaa 1140 gtggtcacac agaacagctc ggtcgaccca gacgatgccg atgatgaaga tgacggaatc 1200 gactttgaat atgctgatgg catgttcaag ccagacactg tgtggaagaa ggccctacgg 1260 gggagcacca gagaagaatc catagcgttg gccgttgaaa aagaacccca tgtgagcttc 1320 tttgtaacca gtgcccaaac ctgcgcatac tacatgcatt tcacactggg ccgtaaatta 1380 cttaaaagat cgtcgaggaa aaatctagcg gcgtgtgtgt atgcagacgg caaacatgtt 1440 caggtcagcg gttgtctccg actgggcatc ttcttttatg agaattcaga ggaaggagaa 1500 acgattttgc aaaggaatac aagtggtatg gaaaaggttg cacttccaaa gccgttctct 1560 gtgcgaaagg gagcttctac gagagtgcaa atgcagaact taactgatgg ctggagcctg 1620 aagcaaggac acaacgagca ggaggtttct cttgaaagtt tctttcaagc gtcgaagctt 1680 gggaaactgg cgtcaagtga ttacataatt gaaaacgaag agaatcccag ctctctcttt 1740 acatgtttgt tcgatctgca ccaagataac aacaaactgg ccgatttgaa agtcatggga 1800 cgtataattg gaaggcaata ctccgtttca tctggttaca attctgatgc gtcgtctttt 1860 caagcagagg aggaatcgta ccacatcaca gaaccagatg ttcccaagac tgatcctcgt 1920 aaatatatga ataggataat tcatcaatta tccccactcg ttactccgaa gtacaaatca 1980 ttctgcagaa ggctgggaat ttcggagatt gcaatcgaca cagccgaaat ggaccgtggt 2040 cgcgaaggat gctatgaagt ctgctgccaa cttctgctgc aatggcttcg caatcacgat 2100 gacgggggac atttgataga gactgcaatg agtgagctca aatcagctgt ggatagaacc 2160 aagcttcagt gtacgattca ttttccaaga gttaaagcga gagagaccat agtttaa 2217 <210> 99 <211> 2736 <212> DNA <213> Artificial Sequence <220> <223> Titin homolog <400> 99 catgttcatg aagaaccaca tactgaagta catcatcatt acgaagaaga acatcatatc 60 cccgaagaac atgttcatga agaaccacat actgaagtac atcatcatta cgaagaagaa 120 catcatattc ctgaagaaca tgtccacgaa gaaccacata tcgatgacgt aacacatttt 180 catgaagaac cacatgctga agtacatcac cattatgaag aagaacatca catcccggaa 240 gaacatgttc atgaagaacc acataccgaa gtacatcatc attatgaaca agatcatcac 300 attcctgaag aacatgttca tgaagaggaa ttcatggatc atatgcatca cgaagagcca 360 tttttgagcc acatccatca cgaagaagga caatcgcaaa tgcaaagtga tattgctcat 420 gagttacatg atacgaatgt attcagcaat gtagtacctg aaatgcctgg tactctgcat 480 gaagatgtgc attcgccagg aatagcacca gaactagcag aagcaaatgc acatagcaat 540 gttgtgcctg aaatgccagg tagcatacac ggtgatatac atgaaaattc gcatgagttg 600 tttgatgggg ccaccccagt ttcaagagat gcaactgcac atagcagttt tgtagcagac 660 gagcatcatg atgatcatgc tttgccaatg cacacagatg aagcgcatga accattgcac 720 gggtttgatg agcatggaaa agaattctat cttggtggaa tcaaaccaca gagtgacgaa 780 gcaactgaat cagtaggagg tagctcaaag catggccttc ctgctgcaaa tggtcatgaa 840 gatgaaaatc aagttcatat cgatgagaaa gatttggaat tagagaagaa agctcaccaa 900 aacgaaatag tagatcctcc atttttaaga cataatgata tgcatggaga tggttatggt 960 gcaggtgttg taccaggacc agatattaat gttggcggtg gtggagcaag tcatacaggc 1020 acagggtcct ctttgacggc acctgtctca gtttctctcc cggaaatcat acccgatgca 1080 gcaccatatt taactgatca tcctgcacat gaaatgcttc atgaaatgga acatggtcgt 1140 aagagggagt catttgccaa gcctaataat agcaataaca ataataataa gaataagaag 1200 aaggtatggc caggcatggt gagcattgga aagccaaaac aacctagtgt aacaagacag 1260 aagaaaaacg tagctagtag tagtcatgca aagggtgcaa agacgattgc aaagaatgga 1320 ggaatcaaga acagtgttat gaagcccaaa gtatcgaaat ttatctctgg aagtagacgc 1380 gaaagtttgt cacacgtaca atggactaag acaagtgacg atccaattca gataaaacca 1440 aaaagtgttt ataaaacagt accaaatgag ccgcatacat tgattaaaac tgtaccaaac 1500 gaagaaatca aaggaaacga agataatgca tcaatgatag tatcattggg aagtagcaac 1560 gagcaagaac aaaacaatac gaacagcgta tcaagcaatg tgtcagcgaa tgataaagcc 1620 acttctaccg aaaaagatac tgatatcaat gtggataagg ttgtggataa aaacaaagac 1680 cagccagagg atagcaataa aggcgacaac gataatgcaa aagaaaaaga gaaaaatgat 1740 aaggataatc aaaagaacga taacgaagaa catgttaaga gcttcaacaa agggggccac 1800 agtgcttttc atgtgagaaa taaaactgta agttttccat tttttgctaa caactccgaa 1860 acagcctcga acgaggaaga gaatttagag gattcagaat tcataacaac tagcttcgaa 1920 agcactggaa ataaaaatca aaatagacag ctgagtgaaa aaaaagcaaa cgagggaaaa 1980 aatgaatcaa cagatgagga agatgcaaga aagaaaaaag aagaggaaga gaagaaacag 2040 agagaaaaag aaaaagaaga gatgaaagaa aaactgaaga aagaagaaga agagaaaaag 2100 aaacaaatgg aagaacagag aaaaaagaag gaagaagatg acaaatggat aaaggaacgg 2160 gcggagaaaa ttaaaaaaga gaaagaagaa aaacaaaaaa aggaagaaga ggaaaataaa 2220 aaaagaatag aggagttgaa gaagaagaag gaagaagaag ataaaaagaa aaaggaagaa 2280 gaggctaaga agaagaaaga ggcagaggag aagaggataa aagacgaaga agaaaagaaa 2340 aagaaagagg aagaagagaa aaagatgaag gaggaggcac tgaagaaaca gaaagaggcg 2400 gaaaaagaag ctaaggaaaa attggaaaaa gaagaaaaag aaaaaatgga gagagaagaa 2460 gaagaaagaa aaaagaagga agcagaagag aaatggatta aagagcaggc agagaaagtt 2520 aagaaagaac gagaagaggc gaaaaagatt gaacagaggg ataacatgaa aagaacgaag 2580 gagttaaaaa agaagatgga agaagaagca aaaatgaaga acgaggaaga agctagaaag 2640 aaaaaagagg cagaggaaaa aaagatcaaa gacgaagaag aaaagaagaa gaaagaagaa 2700 gaacagaaaa ggatgaagga ggaagcggaa acgaag 2736 <210> 100 <211> 867 <212> DNA <213> Artificial Sequence <220> <223> TPX2, microtubule-associated <400> 100 atgaacggtg aatcgggatt accagatttg gctcgattac cgctaactga aaccaagcca 60 tttcggtttg aatctgataa tagattagag atgagaaaga aaaatacgaa agacgaagat 120 cttaacgaga aaagtaaaac acaacatgaa aaacaatccg acgtgactga tgcgaatgta 180 tctcatgcat ctcgtaaaag atcccttcca aggaagactg agccaaagcc attcagtttc 240 gaaacaaggg acaaagcaat gctacaaaag aaacaggaaa agatacaaaa gatattagaa 300 gacgaagaaa aagcaaggga attccacgca agaccactgc cagatctatc tcctgaccac 360 gtcattgtta aaccaaacag aatcgtcgaa gcgaagccat ttaatcttgc tacggatgaa 420 cgtggggcag ttagggttca aaaatggaaa tgtgaactta agaaggaact ggagggtgaa 480 aaagaaaaag taaaattcaa agcccaacca tgcaaagttg ttcaccagga ggcatttgta 540 ccaaagccat cgtcaaagcc tcttgttgag atcaatggat tcaaattgaa cacggaagag 600 aggtcgaaaa agcgcgaaga atattatacg tcagtcagcg aatgtcgaaa aaacagagaa 660 aacgaaatgc aacagaatat taaagagaca caagaagttg aagaagagga gattaagaaa 720 ttaagaaaac aaatggttca tgttgctaat ccggtcagga agttgggtga aattgtgatc 780 aaaccaagtg aaaaaccagt tacgctgcca gaaacaccga aatttgaaac gaataaaaga 840 tttggtagca gagtgtcaag attgtaa 867 <210> 101 <211> 912 <212> DNA <213> Artificial Sequence <220> <223> transcription factor 15-like <400> 101 cagataatca agagcatagc aatttcaaac gatggaccga acgctctctg tctctctctc 60 tctcttcgct ttgctcctct tgaatgcagc cgcaccattg cgacagacat aactgaacgt 120 caacatccat ctcatgcaag atcaagcgag agagagagag agcggagcaa gcagccacat 180 aacaagacaa gacctgaggg ttcagccatt tgcaacatgg atttcttgga cgatttcgat 240 gacttcgaca cgccgactga catgtgttat gacgatgcca aaacgtccac cggtagaagc 300 acatccagcg aagacacgac ggcaaagaag accaagcagc cttcatcccg tcgcaagccc 360 aggcgacgga aacgaatgct aacaggtgta agtaaacagc gcagggctgc aaacgaacgg 420 gaacgaaaac gattgcagat catcaacaat gcgtttattg gattgaaaga ccttctgccg 480 ttgttaccgg gcgaagagaa tatttcaaag atcgatgtcg taaaattggc atcaagaaca 540 atattattac tgaaggagat cttggatgat tgcgacagga aggtggagaa tgaggaagaa 600 agaagctcgt gcgccagttc atcttgcagt ggttcaatcg attctattga agaagacagc 660 agctctgtat taagcaattt tagtcaagag aatcaggact tttcgtttct actattcccg 720 tctgatgaca taaaattcaa tgcttttggc gattctgttg attctggcct gggtatacct 780 tcgccttgca tatcagattc ttcgtcttac acaacttcgt ctaaagaaag ttccgaattc 840 ccttttatgg aagacgatcc aattcatgat gacgatgtct tctgcaaagg gccaacaatg 900 tgtctctggt aa 912 <210> 102 <211> 741 <212> DNA <213> Artificial Sequence <220> <223> transcription factor ETV6-like <400> 102 atgcatgaac tcgagctttg gtttttgtca aatgaccttt actcaattac ccagcaagat 60 attatgagca ttatcaacaa cattgatgat tgtgagggaa cgttactcac ggacaatgat 120 atccccgact ttcagcagat agaagacatt atactcgatt ttgaccgtgg tgatcaccat 180 gaagccactg caataggcaa gggttggcat gtcgttgata cacacggaga tttttcatat 240 gttgatgaca aagttgatga tgataatgat gtctttatgg agccagtcgg tgcttcaatg 300 caagtctttc cttcaccaga gaggaaggat tctgacgagt cggattatga aggctcgttg 360 tcttctacaa acgcgtcggt gagtgaggag gctcctgcaa caagcggaga acaaagacgg 420 aacaggaaaa atagaaagaa acccttggaa tccaaaacac tgctggcaaa atcgttgatg 480 gaatggttgg aggacgacca gctgaaccca tcagcaataa catgggtcgc taaatcagaa 540 ggtttgtttc aaattatcga ctcgacaacc atagctaggc tgtggggtgc catgaagggt 600 aacagccgaa tgacacacga aaaactcagt cgcgctttgc gtcactatta taacgacggt 660 accatggagc ggttggtggg gaaaaagaag ctccgttaca agttttctga ggccgcgatg 720 agaaagttta agctgaaatg a 741 <210> 103 <211> 1443 <212> DNA <213> Artificial Sequence <220> <223> transforming growth factor-beta-induced protein ig-h3-1 <400> 103 acgacgaaag aagtcacaga ggctcctaca acgaaagagg aaccaacaac tcttccacca 60 acgacgaaag aagtcacaga ggctcctaca acaagagaag aaccaacaac tataccaaaa 120 actaaaccaa ccactccaac agtttctgtt tgctcaaaga atcccatcga agtatgcagc 180 gacgtattca gctttaccaa acttccgaat aacatacagc aggtgagggc agaattaaat 240 cagttttctg cgttagttaa gacaggttgc tctgctcacg tgaagaggta cgtttgttcg 300 ctgtatacac ctccttgcgt acccggagag gatataaagc tgctcaggcc atgccggtct 360 ttgtgtattg ctgttcaaga tagctgcatt ggatatttga ataacgtgaa gttggctgac 420 agctttgact gctcaaaact accgtctgat gcatctgggg catgcctcgg aattccaaaa 480 cagacaacag aagcaacaag agttcgtccc accacacaac tcccaaatga agtcgtgaga 540 cgaaaaaatt acgaagaacc aattctgaat ttgaaagaga cacttctcaa gaacaagctc 600 acagtatttc tcaaatactt gaatgaattt gatgacgtga ggtcaatcct gactgacgat 660 gccaagaagt atacgctttt tgcgccgaca aatgaggcat tttcaaactt gaatggcaac 720 acaagaaaaa gtttcctcaa cgacaaaact tatcgaggtc aaataattaa atatcacata 780 attccacgag atgtcaagac caaagagcaa cggtttaaag agtttaaaac gctaactggt 840 agaccactga ttgtgaggtc ctacgacaag cgaataatgg ccgaccacgc tgttattcta 900 tcacacgacc aagcagcaac aaacggccaa gtgaacataa tcgatcgatt aatgattcct 960 tatgaaaatc acgtgatgac agtgctcatg aaccgtgacc aaccttcagt atctttattc 1020 cgaaaagcca ttgaattaac tggtatggcg gacattctca agaagcaatc cacctatcga 1080 tacattgtat gggctccgag tgatgacgct tttctgaagc tatctaaagc cacattgcag 1140 ttcatgttta cgaacatgga ggtactgcga aacatggtta acttgcatat cacgcccggc 1200 tacttccaca cgaatttgat gacgacacga tgggtctacg tgttcagatc gaggatacca 1260 ggcatcagac tgagggtgag gaaattgtcg caagctcaaa acggcctctt ggtgtataac 1320 attatagacc gcgcagcacg cagtgttcag ctcaatctcg gcgctactaa tggtatcatc 1380 aatgttattg acacggtttt atttccaccg aatgtcaaat ttccagacaa tgccaagtat 1440 tga 1443 <210> 104 <211> 1506 <212> DNA <213> Artificial Sequence <220> <223> transforming growth factor-beta-induced protein ig-h3-2 <400> 104 ccaacgacaa aggaagttac agaagctcct acaacaaaag aagaaccaac aactcttcca 60 ccgacgacga aagaagtcac agaggctcct acaacgaaag aggaactaac aactcttcca 120 gttacgacga aagaagtcac agaggctcct acaacaagag aagaaccaac aactatacca 180 aaaactaaac caaccactcc aacagtttct gtttgctcaa agaatcccat cgaagtatgc 240 agcgacgtat tcagctttac caaacttccg aataacatac agcaggtgag ggcagaatta 300 aatcagtttt ctgcgttagt taagacaggt tgctctgctc acgtgaagag gtacgtttgt 360 tcgctgtata cacctccttg cgtacccgga gaggatataa agctgctcag gccatgccgg 420 tctttgtgta ttgctgttca agatagctgc attggatatt tgaataacgt gaagttggct 480 gacagctttg actgctcaaa actaccgtct gatgcatctg gggcatgcct cggaattcca 540 aaacagacaa cagaagcaac aagagttcgt cccaccacac aactcccaaa tgaagtcgtg 600 agacgaaaaa attacgaaga accaattctg aatttgaaag agacacttct caagaacaag 660 ctcacagtat ttctcaaata cttgaatgaa tttgatgacg tgaggtcaat cctgactgac 720 gatgccaaga agtatacgct ttttgcgccg acaaatgagg cattttcaaa cttgaatggc 780 aacacaagaa aaagtttcct caacgacaaa acttatcgag gtcaaataat taaatatcac 840 ataattccac gagatgtcaa gaccaaagag caacggttta aagagtttaa aacgctaact 900 ggtagaccac tgattgtgag gtcctacgac aagcgaataa tggccgacca cgctgttatt 960 ctatcacacg accaagcagc aacaaacggc caagtgaaca taatcgatcg attaatgatt 1020 ccttatgaaa atcacgtgat gacagtgctc atgaaccgtg accaaccttc agtatcttta 1080 ttccgaaaag ccattgaatt aactggtatg gcggacattc tcaagaagca atccacctat 1140 cgatacattg tatgggctcc gagtgatgac gcttttctga agctatctaa agccacattg 1200 cagttcatgt ttacgaacat ggaggtactg cgaaacatgg ttaacttgca tatcacgccc 1260 ggctacttcc acacgaattt gatgacgaca cgatgggtct acgtgttcag atcgaggata 1320 ccaggcatca gactgagggt gaggaaattg tcgcaagctc aaaacggcct cttggtgtat 1380 aacattatag accgcgcagc acgcagtgtt cagctcaatc tcggcgctac taatggtatc 1440 atcaatgtta ttgacacggt tttatttcca ccgaatgtca aatttccaga caatgccaag 1500 tattga 1506 <210> 105 <211> 738 <212> DNA <213> Artificial Sequence <220> <223> transient receptor potential cation channel subfamily M member 2 <400> 105 atgcctgaag cccaaggaaa gaagaagtca cagaacggtg cgacggagca aaaagttcct 60 gtcatataca caaaattcca caagaaaact tgcaactgtt ttcatgcgga atatcgagat 120 aaccaaagaa gcttgtgttc ctgtggaaga tcgatgggag atcacaataa agaagcactt 180 gacagtggta gacatggaga gccatggagt aacaaagagc atgtaacaac tgcacctaca 240 aatgcttatg gaaaaattga atttcatggt ggtcaaggtc tacgaaagag aagagccaag 300 tatgttcgcg tgtctaatga ggataacttg gatgatgtag taaatttact gctggatgaa 360 tgggaattaa gacacccgaa gcttttgatt tctgttactg gtggcgcaaa aagtttaaaa 420 ttgccagata agttaataca accattcagc gatggtttgt taaaccttgc caaaactaca 480 aatgcctggg tgataacagg aggaacaaat acaggtgtca tgaagcatgt tggagaagca 540 ttgcaagaag tctcaagaga aactatcctt ccagctaacg acgaggaacg gagatacgtc 600 ccatgtattg gaatagccag ttggggaata gtgggacaca gggaaaagct tgtgcaaaca 660 tctaatactg cttttgaata cttcatgctg aacagtatga aaaagagtgg ggcatacctt 720 gacaataatc acactcat 738 <210> 106 <211> 1020 <212> DNA <213> Artificial Sequence <220> <223> transient receptor potential cation channel subfamily M member 3 <400> 106 accactgaag aaatcagaca gattttccag tcagaactga aacagctgaa tggaaaattt 60 cacgaatgga gccaaagtaa atggaacatt tgtgatggga ttgcaattgt gttgttctac 120 gttggacttg gccttcgttt gttcactttc acgatgggtg ctggccacgt tatctggtct 180 attgatataa tgctttggat ttttcggctg ttggaaattt tctcattcaa ccagcatctt 240 ggtccatacg ttctcatgat tggaaggatg gttaaagact tactctactt tttgttcatc 300 atgttcgttt tcctctttgc gtatggtgtc gcaagacaag cattattgca tcctgtttca 360 ccattctcat gggcagcaat tgctgaggtc ttttttactc cttattggca aacgtacgga 420 gaattgttct tgcacgaaga acatttatta actggctcga aaacactttt caacaccaaa 480 aaatacaacg catacgctga gccaatagtg tcaattctca tggcctttta tatgcttgtg 540 gctaacatcc tactattgaa tttgcttatt gctattttca atagcactta tgaagatgtg 600 aaagcaaagt cggacgaagt ctggaaagtt caacgatatt accagctctt ggaatattac 660 agaagaccaa tacttcctcc cccttttgtg cttataaacc atcttatttt gctgtgcaat 720 ctgtgttgtc atacagcatg tcgtgatatt ataaaacgca atgaaatgaa atttttcccg 780 acgcgcgatg gacgatccga tattcgaaga ttcgaagaag aatgttttgc ggaattgcta 840 agaaaaagcg acagtaatcg tgcccaagat aagatagagc tggcatcaat gaatctcact 900 tctatccttg aatttttgaa ccagaacggc agcgatgaag ttgatgaact ggacacgggt 960 atcttcagat tcatcaagat gaaaattaaa gcagcacttt tcaatctgag aaggagctaa 1020 1020 <210> 107 <211> 1791 <212> DNA <213> Artificial Sequence <220> <223> Trehalase <400> 107 atgatggatt cagtgatgct catgttcatg ctttgcattg ctattgcgtt tcacattagc 60 attgggtcat ccagtgcgaa tgctgaaaac tttacagtag catgccaggc aaaggtttat 120 tgcaacggct ccattctcca ccgagtacag atgtccaagg cttttggcga tgctaagacg 180 tttgttgaca tgccgatgag ggacgatccg aatgtgatca tacccaaact tgagccgaaa 240 ctcaaacagg ctacgactaa acaacaagtc aaggaagctg ttgatatgtt cttcactaaa 300 gccggcactg aattggacaa tttcacgccg aatgactggc aagataggcc gtcaattttg 360 cagaatatcg acgatgccag gttgaaggat tgggcgaagg atctcaataa ccgatggaaa 420 aatctaacaa ggaaaatgag aacggaagtg aaaacaaagc ccgacagatt ctcgttgatc 480 tactcgaaga atccgtttgt cgtgccgggt ggcagatttc gcgaattcta ctactgggac 540 acgtattgga ttgtcaaagg cttactgctg tgtgacatga aagacacagt gcggggcatg 600 cttcagaatt tcatcgagta tgtcaagaaa tacggcttcg ttcccaacgg gggcagggtg 660 tattacttaa acaggagcca gcccccattt ctcaccctca tggcagcgaa gtattacatg 720 gcaacgaatg acacagcgtt cttggcacaa acactgcctt tcttggaacg ggagtatgat 780 ttctggatga agaagaagca agtgacgctt ggtgctcagc acggttttca atcaccggtc 840 aacctgaatc attactcgac gcccctcggc caaccgagac ccgaatctta ttggaatgac 900 gtggaaactg caatcgaggc tggcgtttat cagaacgaga ccgaacggcg gcaacttttc 960 gcgcacattg cgtcagcagc ggagagtggc tgggatttct cctcgcgatg gttcgcctat 1020 acgggaaagc atgccatgac gatgaaatcc ataaagactc gtgatattgt tccggttgat 1080 ttgaatgcta tattgtgcag agttgaacgc gagctcagct cactgtctgc atcggctggt 1140 aatgcaacga aaagtcgtat ctaccaacaa gcgtaccagc aacgcatgaa gaacatcaac 1200 agggcgttct ggaacgaaga gaaaggacag tggttggact atgacatgca gtcacaaaaa 1260 cacagatcgg aattctacgt atcaaatatc tcaccaatct gggccgattg ttttgaatcg 1320 aatctcacac gtgccaaggt ggcaattgaa tcgatcagga aacaaggtgt cctcaaatac 1380 cctgccggtg ttccaacatc gcttcgccga acaggggagc agtgggatta ccccaacgca 1440 tggcccccgc ttcaggacat gatggagggg gcactgaggc gatcaggaca caaggacctc 1500 gcttttcagc tggctaaaaa ctggatcgat acaaattact ttggatggaa gaaaaccgga 1560 cacatgccag agaagtttga tgctaccgtc aaggggggta tcgggggtgg gggcgagtac 1620 aaggtgcagc ttggttttgg atggaccaac ggagttgtct tagactttct caaccgatat 1680 ggtgatcgtt tgaaggcgcc gaacagtggc acatctgcac ttatgataaa cagtgttttg 1740 ttctttactt tgggtgtttt gtctccactg cttactcatc tgatggaatg a 1791 <210> 108 <211> 729 <212> DNA <213> Artificial Sequence <220> <223> tropomyosin-1-like <400> 108 atggaggcaa ttaagaagaa gatgaccacc ttgaagagaa ctcaagaaga agcagaagaa 60 agagccagaa aagccgaggc cgagcttgca gaaaccaatg ccaaagctca agcagctgaa 120 gaagatgtta ctagacttct gaatgagatg gagaaactcg aggaagacct agatttaacg 180 gaatcaaagc tgaatgcaac ccaacagaag ctgggcgaag cagagaagca agcagacgag 240 agtgagagag caagaaaagt gctggagaac agaggagtca gtgatgatga aagacttgca 300 agacttgaag ctgaattggc cgatctgaca gccaagaatg caaaagtgga agcagagtat 360 gatgacactt gcaacgagat caatgatttg gagcaagaac ttgacgatgc tgagaataga 420 agtggggaat ttgaggcacg tgtaaaggag ctagaaacag aggtcatggt tgttggtaac 480 aacttgagaa gcttggaaat cagcgaagga aaggcctctg agagagaaga cagttatcag 540 agcaaactca atgatctcag tgagaaattc acacagactg atgcacaagc gacagccctt 600 gaagatcgcg tgaaggattt ggaagaacag ctcataaccc ttgaagatga agtcactctc 660 gaaaaagaag agtacacgaa gttgaacact atttatgaac aaactttgtc ggagctttca 720 atgatgtag 729 <210> 109 <211> 1272 <212> DNA <213> Artificial Sequence <220> <223> trypsin-3-like <400> 109 atgatgctaa tcaaagcact tctcttgatt gctctttcaa ttgtttacac caatgcagcg 60 aatccttgcg atgacataga gaaagatttt tgcagtactt gggcaaaaaa aggttactgc 120 acgaaaattt atatgaccta tatgaagaaa aattgcaaga aaacttgcgg atattgccca 180 aaaaagaatc cagagtgttt gaacgaacca gagcatgaca aaaactgcga gaactattgg 240 aagggtttct gttcacgaaa atcacaatac ttttcattca tgaagaagaa ttgcaagaag 300 acatgtggac tttgtcctgc acaaacaact cttccaccaa cgacaaaacc caaacctaaa 360 ccagcctgca aagatactcc caagcatgcg aagaattgcc ccggttttaa aaggttctgt 420 aaaaaggcaa gccgatggtt taaatggatg catgacaact gtcccaaaac atgcaaattc 480 tgccgagacg actgtggatt aagagggcct gtccaaggaa gagttattgg aggtgttgaa 540 gccgaagccc attcatggcc atggtctgtg gctcttctta gatttggtgg gtatttctgt 600 ggtggtacat tgatcgatga acaatgggtt ctttctgcgg cacattgcat ttatggacgg 660 gaagaccagc ctcagtttat tcaagctgtt cttggagagc atgataggtc tgtcaatgga 720 aaaactgagc agaagtttga tgttgcaaag ataattccac atgctgacta tgactcgagg 780 acactggata atgatattgc gatgataaaa ttgaaagaga aagttgtttt gaagaaagat 840 aagtttggta atccagacaa agtcggactg gcttgtttac caaaacaagg agaggcagcc 900 aatatcaaag atttgtgctt tattactggt tggggaaaga caactggtga tggcacaagc 960 agtcagattc taatggaagc tgaaatgcca acggttacta acaggaaatg caggaaactg 1020 aatcaaaaat ggggaggaac agccattaca aaaaacatgt tgtgcgcagg acaggagcct 1080 gggacaaaaa tgagcggttg tcatggtgat tccggtggtc catacgtgtg caccaaaaat 1140 ggtagaaagt ggacactgac tggtgcagtt agctggggat catccagatg tgacaggagt 1200 gagaaataca cagtgtttgc ccgtgtcagt gagttcagag attggattga caacatcaga 1260 aacactaatt ga 1272 <210> 110 <211> 864 <212> DNA <213> Artificial Sequence <220> <223> UPF0705 protein C11orf49 homolog <400> 110 atggagtcgg ctgaagaaga tgcctgtctc actacagaac aatatcttgc caagcatcac 60 cttataattt actttgagga tgcagtgaca caactacttg aatataagga ggataattca 120 aaagttaatc caaaaacatt cttccatgaa tattttacca gtgtcatgca tggtaatcat 180 acattgttca gagacttcag tttcatcaga tcgacagcac ataatagagc atcgttcatc 240 cgaacgtttt tgaagtgttt ccgccaagtt ggcaaaaatg gagagttatt gattatcaaa 300 gagtactatt cacttgttcg ccttttgtgc cccgatttcc catttgaaat tctccaaaag 360 actgccaaaa tcatcttgat ggacgatgca atggattgtc tcatgtcatt ctctgacttt 420 ctttttgctt tccagctaca gttttatttc gaaacttttc ttgagaaatg ttcagacatc 480 tatcacaatc tgcttgagct ctccaagagc caacaagact ctgactcaac gaatggtgtg 540 cttgatgaca tcagcagttc tttgttcatg gaaactatac gcaaagacat ctacaagaag 600 tgtttgaata cgaagttctg ttgtcctcca ctgcctgccc tgcaagaaat cctcaaccca 660 gtcactcgcg tttctttcta cggcttcctc atggctctga ctaaaagtcc cgctgtcaat 720 tctagcatcg gtgtcttgcc agataaatca tgcttaatgg atttcaacga aaaagacggc 780 acagcagcga gggcatcgcc aagacccttg agtgccaagc ccccacgacc accctcggga 840 cgaaagacga aaacagaaca ttaa 864 <210> 111 <211> 1824 <212> DNA <213> Artificial Sequence <220> <223> zinc finger CCCH-type containing 12B <400> 111 atggatggag ttaacgagtt tgttatacca tttgataaag gccttattat aaggaatcag 60 ttttgtcgac aaattgagac tttgtttcat gttcgtcttg agtttacaac tgattggagc 120 acagcgcaac gtactggcaa cgagtggatc aaaatatgtg gaaatgaaaa tgatagaaag 180 aaagctgagg aatacacaaa aggaataaca aatccagaga cgagggtttt tttcttgatt 240 cctccatttc tgcaaaacca agtttcttgg aatcgcaacg aagtcatttg gcaagttcaa 300 agagaaagta acgctttggt acaagttgaa aatgtagaga aactgtatct tcaaggctcg 360 gagatgtctg tcgcgtctgc aatatcatta ttggaatgca gaataaacta tttaaaacat 420 caacattcat tttcagcaat caggcctcca atgagttctt ttgcaagcaa taagcccgct 480 acagacattg ttgcaaaagg tgctgagatt gcatcctcac caaatcagcc gcaagtcctt 540 ccaaggggct cagccccgaa accaaactat gatcagctga gggattttgc tacaaaactt 600 ggatattcag aagatgaaat aaaaattgga atctcaaaat gtaccaactt tgtcaatgaa 660 aactcacttt tgaaacaatt aataacactg ttcccccgta acggatcata tgatgtacct 720 gtaactaaat caagcggcag aattagtagc gactgttctg attccacttc aaatattaaa 780 agtaatttgc caaaggattt aatccagaca gcactccagt cttcagatgc tcagcaaagc 840 aaaaaagaca aaagtaaaga caataagtta aggcatattg ttgttgatgg aagcaatgtt 900 gcaatgagtc atggaaacag ggaagttttt tcgtgtaaag ggatcatgat ctgcgttgac 960 tacttcaaga aaagggggca ttctgatatc actgtgtttg taccacattg gagaaaagaa 1020 acatctaacc cagaaagacc aatcgtagat caacaaatat tgacagatct ggaaaaagaa 1080 aggattcttg cctttactcc ttcaagaaaa gtaaatggca gaagagttgt ctgttatgat 1140 gatcggtata ttgtgcggtt tgcagctgaa aatgatggaa ttattgtgtc aaatgataac 1200 tttcgagacc tggaaaagga gaacagtgaa tggaaaaaag ttatagaaga aagactgttg 1260 atgtatacat ttgtaaaaga ctgctttatg ccaccagatg acccccttgg cagacatgga 1320 ccaaaattgg atgaattttt aaaaaaaggc acagttgctc aacctcgttt gtgtccctat 1380 aaaaagaagt gtacatttgg tcagaaatgc aaatactacc atcctgaaag aatggaaaga 1440 agctccactg cctctccaaa gaatatgcaa atggatgctg taaaagaggg aggcagatct 1500 tcacagagtg cagatgcaaa tacatccttg ttgctattga aaaaggacat ggacactaag 1560 caacctcagc aacagacaat ggcacaaaca agaaataacc acatcaacaa ggcagcagaa 1620 gcttgtggtc aagagcaaaa acagtggaac acgttacaaa aatctgccca accttccatt 1680 gtaaacacag aatcgacaga agcctttcaa ctgctgcaaa atatgtttcc tgagaatgtg 1740 gaaacaataa agaaaatcat taccgagaat ccaaaggaaa cagacccaaa taagctggcc 1800 gatctgctgc tcagagctct gtag 1824 <210> 112 <211> 7173 <212> DNA <213> Artificial Sequence <220> <223> zonadhesin-like <400> 112 atgccaattg gtttgatatt gttgatgatg aagttaatgc tgttgtgctt ttttctatgc 60 tccggttatg cagtggtgcc tgtgattggc gatgagttgc gagtgagcag gagagataac 120 attgcagata aacattcatt gccacaaatt ggaggtgcat tatcttctca tgcaaatgca 180 gatgcgaata ctggcgttca tgcgattgta agcaatgaaa caaggcataa aaggacacca 240 caacccagcc caaaggcgca gattttactg cgcacttctc cgtttttaac aaatgatgaa 300 ttgatcacga aaagacaatt tctgcctctt gctccagagc tggctggcag tcgagagttt 360 gcaccgcgta gggagttcga gcaaaccctg cttccaacgc cacgtattat tcgaccgttg 420 gaactcgatt ccagaagact gcctattgat agaggtttat tagaaagagg agaacctctt 480 aatttagatc atggaccact tcttggtcag ggaatgctca gtccgcagct aattcctcat 540 ttaaggaggc aatttgggcc attggaacac tttcataggc cgcttttgca agacgttggg 600 ccacttccat cagaactgga gcaacatagg cacatgctgt tcgatccaag gctcgaaccg 660 catcatgcgt tggagctacc gttcgaacaa cgacctttgc atttccaccc catgcttgag 720 ccgagagtgg actctaccgc ggattcgctg cattacggtt ccctgggtga cacccctttg 780 atggagttgc cgcaacagca ttcgctgggg gagagcttcg ttgctcctca ttacatcggc 840 aatccagagc caattcatcg gttcgaacca tcgccattgc cggagggatt accactagcc 900 gagcctcagc atcgtttcag agagacggta catcctagtc caatgcttcg tcaccatgtt 960 ggtgagaatc tagaggcaga acaagtgccc gacccgacac caagccctga tgatggctca 1020 gatggcgatg atagcatcga aactatgatg aacgaactcg gtaggcataa gaaaagaaaa 1080 gcttgggtta cggatgtgaa tatttatgat aaaaagaaca aggatgatga tatttcgaaa 1140 tttctcgatt cgggtgatga tgatgtcgat gactacaatc cctgtgccgc ccatccttgc 1200 caaaatggcg gacgttgtca cgctaaagac aatggacact acgaatgcat atgcaagaga 1260 tatttcaaag gaaaacattg ttctgttcgc agccggtgcg caatgaaccc ttgccgcaat 1320 cgtggcaaat gcacagaaac agtatccggg tttgaatgca catgcgcagt tggttacaaa 1380 gggagtcgtt gcatggaaag aaaccgttgt cttccgaatc cgtgtctgaa tgaaggcacg 1440 tgcaatgaat ctccagaagg ctttgtgtgc tcatgtggag aatcttacca aggaaaaatt 1500 tgcgaagtgc gacgaacagt ttgcaatccg aatccgtgtc tgaataacgc gcagtgcgta 1560 cttgatggta gcagtcaata caagtgcatc tgtcttcgag gattctcggg aagaacttgt 1620 gacatggcag tagccggcgc tctcatgcaa agttcatcac aacgtagtga catagcagta 1680 cccacgaatt caccagtggc ttgcattaat aacccttgca tgaacaatgc agtgtgccaa 1740 cccgatgcca ctacgctgcg tgggtacaaa tgcgtgtgcg aaagtgcaga atacaaagga 1800 atcctttgtg aagaaaaggt atgcagttgt cagaacaatg gattatgcgt cacaaacgga 1860 ggcacgaata aatgtatctg caaacctgga tatgctggct ttaattgtga aaagcacacg 1920 caatgcaatg atgatacctg cttacatgga ggcatttgtt cagagggatt gggtttcttc 1980 aaatgcaaat gccaagatgg atacacggga gacagatgtg attccatgga tagatgcaat 2040 ccaaatcctt gtcttcacgg aggcacgtgt atgaatgatg gtaataacta caagtgcgca 2100 tgctccaata cctacaaagg aaagcaatgt gaagatttta atttctgttt ccccaacccg 2160 tgcaaaaatg gcggaaattg ctttgggtat tcaggtggat tccaatgcga ctgtgcgaat 2220 ggatttgctg gaaaaaactg cgaaaataag cagtattgtg tttcaaatcc ttgcaagaat 2280 ggaggacaat gcgttgaagt ttccaattca ttcaaatgtt tttgtaattc tggctacagt 2340 ggtagttcat gcgaagtccg taatttctgt gccaataatc cttgtaaaaa cggagccact 2400 tgtcaaaata aaccaaacac ataccattgc acatgcacag aacaatttat tggagaacaa 2460 tgtgaaacct tcaatcgttg ctttgaatca ccatgcaaaa atggcgggaa atgtgcaatg 2520 ttgcatgacg acatcgagtg cacttgtaca attggattcg caggacccag atgtgaacaa 2580 attgacgaat gtcaaccaaa tccttgtcaa aaccaagcag cctgtttgaa taatcctggt 2640 ggagggtttt catgcacttg caaagaagga ttcagaggag tgacctgcgt ggatgttgat 2700 ccatgccatc caaacccatg tacacacggc gtatgctccg agatcaatgg cggatatgtc 2760 tgcaattgca gtttgggatt cagaggtcct gtctgtgcag agattgatcg ttgttctcca 2820 aacccctgct tgcacggtgc aacatgtcaa gaaatcaacg gtggagttgg ttacgtttgc 2880 caatgtcctg tcggctacaa gggacagatc tgtgacatga aagacccctg caacccatct 2940 ccatgtcagc atgatagcaa gtgtcttgaa actgcaactg gttctggtta ttcgtgttcc 3000 tgctcgtctg gatggatggg ccaaaaatgt gaagctgtag acacttgcgt tcctgatcca 3060 tgccaacatg gcgggcattg tttgcacgat ggcaaagctg gttacaaatg caactgcacg 3120 caaggattta aaggcaaaac ttgtgaaaag attgatttat gttctccaaa tccatgtcgt 3180 tttggaagcc attgcattca aacggacgag gagagctacc agtgtgtgaa gaatctttgc 3240 acaccgaacc cgtgtaaaca caaaggcaag tgtatcgtcg tgaatgacga agggttcgaa 3300 tgtgcttgta ctggtggctg gagaggccga aactgcgaag attacgaccc ttgcttctcg 3360 acgccgtgtt tgaatggtgg tacttgcacc gagaactcca atggtggctt cacgtgccta 3420 tgcaagaagg atttcgaagg aaaatattgt ggagcaagca aagcaaaacc aagtgatgtg 3480 cattggtgct catcgcaacc ttgtaccaat ggaggcacct gtatcgaaag tggtggcgca 3540 tttagttgca gatgcaagct tggcttttcc ggaccaatat gcgaagaaag tgtttgtttg 3600 cccaaccctt gcgagaacgg gggtacatgt gtaccgtatt acggcatcgc actgtgcaaa 3660 tgtgttcata attacaccgg agctcactgt tcagataagc gacacgtgaa tgttgaagta 3720 gggtcaacta aagacgccat tatcaaggat gtggctgctt tgtcgaaacc cacggaaaag 3780 gcagcgaatt cgcaatacaa tgttgtccca cttatgccta caaatggggg ctcgtcgaca 3840 agtaatccaa ttacagctgt tgtaatggct aaaaaagatg atccttgtat cagcacatcg 3900 tgtttgcatc atggaatgtg cgtggttagg acagacggac aaccagaatg catttgccta 3960 ccagatttta gtggacctgt ctgcggagaa attggagcct atggttactc atcagctcca 4020 aaattttttc caaaagatga atgcagccat tgtgatgaga atgctatttg tgtaaacagc 4080 cattgcatat gcaaggagaa ttatgttggt gatggattgg agtgttgggc gaaaacaaat 4140 cgtgatagcg aatggagttg cgaacagaac ccttgtcaaa atggtggaac ttgcaagaaa 4200 ggacgatcaa gatgtgtttg cagactaggc tatacaggcg attattgtca aaattattgt 4260 ccgcctgttg tgcatttgag ctttgacaaa atgcaaggtt ccttggccaa agatgaaagc 4320 ggcaatggta acgatgcaat gttgattaat ggagctgaga tcgtttacga aggaggcaaa 4380 tgtgactcgg cagtctctct tttaggtgga gacattttat ttgacggtga acgattctgg 4440 cctaagccta tcgaagctgt gactattgca ttgtgggtaa aactggacac gaacaaaggc 4500 attcagtcga tcttcgacac gattggtgga aagttctcca ctcacaagga gggacaatat 4560 cacgtggaaa ttgagaatgg taaagttcgt tggtttcaca ggaatgagaa acacgcagtt 4620 gtattcagca ttacgtcaac agctctcgtt gccgaaggag cttggaccca cattgcagga 4680 acatatgatg cagaaaaggc catagcaaag ttgtttatta acggagattt ggttgctaaa 4740 ggtccaggca atggattttt atcgcaagat tggacaggaa aagctggcat cggcaaacac 4800 gaacatcctt acgggaatag gctgctaaga ggcatggtgg atgagttctt tatattcaat 4860 tgtgcgctac caagaataga agtcctcgtg cttattcatc attgcaaact ttactttggt 4920 aaaaggaaag actattccca gcctcgcaaa gatgacaaga aaatacaggg aagcttggtc 4980 ggcggattgc agtcaagtgc tcctccgcag ttgcccgccg cctctgcgac atcagatgtc 5040 cagagcattg aaaagatggt gagctcgttg gctccagtgg aatccccgaa tcaacctcca 5100 gctggtatca agctcactgc accggctgac cattgggttt atcacgttgc tgaaaagatg 5160 catctgacag gagatacaag ggctggcatc aaccgaccag ctgctcatcg gcctaatatt 5220 cagcaattgt acaataattt catttcgaaa caacagaaga atagcatggc gcaagccgct 5280 aagcaaccga caccgaacaa atggaagcca ggaacaacac gtccaaaacc gcacgtcgac 5340 gtcaaaaagc ggccattttc ctggcaccct ggccagttca ttatgcaaaa aggagtggcg 5400 aagtcaatgc ccagtcgctc acaaccaccg cctctgttgc gtgcagcttg gaacatggtc 5460 gctgcgaagc aaaggcaaga cgctgcgagg aaaaaacagc tcagccaaca agccaaccag 5520 gagtatttaa tagagagaat gtaccagagt ctattttcca aagcaaaaca accagttaac 5580 gcaaacaatc aattgaaagt aaacgatgac atcatctcaa aggcagcggc cagtgcacct 5640 gccatcccac aaggctatgt tggtcaattc tccatgcata atagccccgg ggcgcataat 5700 caaaatagcc aagggacgat gattagggat agtctgacgt ccaggcagtc tgtctactca 5760 ttgccacaag gcagaactca acaggttccg aagcaggcgt tctatccccc atacgcgtcg 5820 ggattcgcgc agaagaagaa tgaaattaac aacttcatga aacaaaatcc actgtggtta 5880 gctggcgatg ccaagtcagg tgtaccaaaa gcagcaaaag ttgaaggaaa gaattcaccg 5940 agctacaact ttgctcagta cacgagtatt ccatcggcct tgaagccaaa ggcgttgtcc 6000 ctaatcccag acccgtcaga aattttttac ggcaagcaac aacgaggaca gaatggagcc 6060 aagacgatgc cggtgcgagc caattcggcg ccaagcagaa actggtacca acaacaacaa 6120 caacaacagc aaaggcgaca acaacaacaa caacaacggc gacaacaaca acaacagcaa 6180 agggctgcgc aaagaaatgc gaagaggccg ctatcgaatc gtcctgttca actagaacaa 6240 caacgaaagc ttaacggtat ggttacttct ccgcaggcaa agcaagattt ttggcctaag 6300 ccgaatttcg tcgaagaata cgcgacaaat cgtggtattg tgcgcgtgca gtcgataaca 6360 agaccattgc attcaaattt agcggcagca aagccaaaag ggtccatgcc agtgcaacgc 6420 aactcaaggc cacagaagac gagtttctcg gtcttgaagg atccctggag tgtttacacg 6480 cgtttgagcg cggcaaagag acagggttat caacaagccg actcacatgc atccaccgca 6540 acgtcatcga acacgatgga aggtgctacg gctcccggcc agaaaggagc cggtcataat 6600 tacggctacg gctatggata tggaactgga gaccagttga aaggtggtgg atggggtcag 6660 ggcttcgggg gaggtggccc cggagagaac caagcaggca cgcatcatac tccagacttc 6720 aacaatccca agatgcaatg gtcgcacgga caaggctggg gacagggggg caagggagtc 6780 caacaagaga cacagaataa acctaaccca cctgccggct tcccgtcatt ctttccgccg 6840 gcggccagac aaaaaattgc aaaacagcaa caaaaatacc ttgctcccag ggggccatca 6900 ataatgaact ttggttcgca agcagcagtc aggagtagca gtaataaaca gcaaatgaaa 6960 caaatagaca atttattctc tttgcgagat agcacgcccg tctcaagccc ggcttatcaa 7020 gtcaaatatt tcgcaacccc agcaaaatcc gggggttatg tagacgacag tgattcggcg 7080 aagtcattga gaaatcaaat catatcgaat gcaattgctg acgcattgaa atcgattcaa 7140 aagaagaaaa gaacagccaa agaaaatcta tga 7173

Claims

서열번호 1 내지 112로 기재되는 모든 유전자 각각의 핵산 서열을 구성하는 올리고뉴클레오티드 또는 그의 상보가닥 분자가 집적된, 말레이해파리의 고온 스트레스에 대한 노출 여부 검출용 마이크로어레이(microarray) 칩.
제 1항에 있어서, 상기 유전자는 말레이해파리(Sanderia malayensis)로부터 유래된 것인, 말레이해파리의 고온 스트레스에 대한 노출 여부 검출용 마이크로어레이 칩.
1) 고온 스트레스에 노출된 실험군의 말레이해파리와, 정상 대조군의 말레이해파리에서 각각 RNA를 분리하는 단계;
2) 단계 1)의 실험군 및 대조군의 RNA로부터 cDNA를 합성하면서 실험군과 대조군을 각기 다른 형광물질로 표지하는 단계;
3) 단계 2)의 각기 다른 형광물질로 표지된 cDNA를 제 1항의 마이크로어레이 칩과 혼성화시키는 단계;
4) 혼성화된 마이크로어레이 칩을 분석하는 단계; 및
5) 분석한 데이터에서 제 1항의 마이크로어레이 칩에 집적된 유전자 발현 정도를 대조군과 비교하여 확인하는 단계를 포함하는, 말레이해파리의 고온 스트레스에 대한 노출 여부 검출 방법.
제 3항에 있어서, 단계 2)의 형광물질은 Cy3, Cy5, FITC(poly L-lysine-fluorescein isothiocyanate), RITC(rhodamine-B-isothiocyanate) 및 로다민(rhodamine)으로 이루어진 군으로부터 선택되는 것인, 말레이해파리의 고온 스트레스에 대한 노출 여부 검출 방법.
1) 고온 스트레스에 노출된 실험군의 말레이해파리와, 정상 대조군의 말레이해파리에서 각각 RNA를 분리하는 단계;
2) 단계 1)의 RNA를, 서열번호 1 내지 112로 기재되는 모든 유전자 각각에 상보적이고 이를 증폭할 수 있는 프라이머 쌍을 사용하여 정량 실시간 RT-PCR(Quantitative real-time reverse transcript polymerase chain reaction, qRT-PCR)을 수행하는 단계; 및
3) 단계 2)의 유전자 산물을 대조군과 비교하여 발현 정도를 확인하는 단계를 포함하는, 말레이해파리의 고온 스트레스에 대한 노출 여부 검출 방법.
제 1항의 마이크로어레이 칩을 포함하는 말레이해파리의 고온 스트레스 노출 여부 검출용 키트.
제 6항에 있어서, 스트렙타비딘-알칼리 탈인화효소 접합물질(strepavidin -like phosphatease conjugate), 화학형광물질(chemiflurorensce) 및 화학발광물질(chemiluminescent)로 이루어진 형광물질군으로부터 선택되는 어느 하나 이상을 추가적으로 포함하는 것인, 말레이해파리의 고온 스트레스 노출 여부 검출용 키트.
제 6항에 있어서, 혼성화에 사용되는 완충용액, RNA로부터 cDNA(complementary DNA)를 합성하기 위한 역전사효소, dNTPs(deoxynucleotide triphosphates) 및 rNTPs(ribonucleotide triPhosphates, 사전 혼합형 또는 분리
공급형), 표식시약, 및 세척 완충용액으로 이루어진 반응 시약군으로부터 선택되는 어느 하나 이상을 추가적으로 포함하는 것인, 말레이해파리의 고온 스트레스 노출 여부 검출용 키트.
서열번호 1 내지 112로 기재되는 모든 유전자 각각에 상보적이고 이를 증폭할 수 있는 프라이머 쌍을 모두 포함하는 말레이해파리의 고온 스트레스 노출 여부 검출용 키트.