KR101787337B1 - the fermented samultang extracting method with the function of both anti-oxidation and immunity and the samultang extract using thereof - Google Patents
the fermented samultang extracting method with the function of both anti-oxidation and immunity and the samultang extract using thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/308—Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention
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- A23Y2220/03—
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- A23Y2220/17—
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- A23Y2220/29—
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- A23Y2240/75—
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- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
More particularly, the present invention relates to a functional physiologically active composition using a herb, and more specifically, a fermented sweet pot with antioxidant and immunizing effects obtained by fermenting a mixture of Sukjungguk, Baekjaek, Cheonggung, It is about samtang.
The present invention relates to a process for preparing a composition which is prepared by mixing Sulfur,
A process of inoculating L. elbruekii, L. acidophilus, L. casei, S. thermophilus or / and Yo-mix into the above-mentioned extracted composition to ferment,
Wherein the fermented sweet pot has an antioxidant activity and an immunological effect.
The present invention also provides a method for preparing an antioxidant and immunostimulatory fermented sweet pot with antioxidative and immunostimulating properties, characterized in that the composition is prepared by preparing a composition which is prepared by mixing a mixture of Sukjiro, .
The present invention also provides an antioxidant and immunostimulatory fermented sweet pot with a composition which is prepared by preparing a composition which is prepared by preparing a composition prepared by mixing Sukjungguk, Baekjaek, Cheonjung, and Angelica gigas .
The present invention also provides a fermented sweet pot produced by the above fermented sweet pot production method.
Description
More particularly, the present invention relates to a functional physiologically active composition using a herb, and more specifically, a fermented sweet pot with antioxidant and immunizing effects obtained by fermenting a mixture of Sukjungguk, Baekjaek, Cheonggung, It is about samtang.
Modern society is threatened by the improvement of living standard due to industrialization and lifestyle change, and dietary changes are changing, and various adult diseases such as obesity, hypertension and hyperlipidemia are increasing rapidly due to such dietary changes. In order to overcome these problems, various health-oriented products have been developed. In recent years, there has been a great demand for medicinal foods using herbal ingredients, and there has been a growing interest in medicinal herbal tea which is easy to drink anytime and anywhere .
Generally, Chinese medicine refers to a medicine prepared by mixing natural or processed medicines for the prevention and treatment of diseases based on the basic theory of Oriental medicine. Extracts of various animals, plants and minerals are extracted and used, but most of them are medicinal plants I am using it. Each of herbal medicinal plant extracts exhibits a unique high level of physiological activity, for example, a herbal composition of a specific composition has anticancer activity, antidiabetic activity, arteriosclerosis prevention activity, immune function enhancing activity, hangover elimination activity, stroke prevention, Activity and the like are known.
Heretofore, the Korean registered patent includes a herbal composition for cancer treatment and cancer prevention (No. 10-0671762, January 15, 2007), a herbal composition for treating and preventing diabetes and its complications (No. 10-0712659, 2007 Extracts for the prevention and treatment of arteriosclerosis and related diseases of herbal medicine preparations including antimicrobial agents, antioxidants, antioxidants, antioxidants, antioxidants, antioxidants, antioxidants, antioxidants, antioxidants, antioxidants, And a medicinal composition for preventing and treating diseases and related diseases (10-0787174, 12 December 12, 2007), herbal medicine extract for treating lupus (10-0682046, February 6, 2007), hangover (10-1176590, August 17, 2012), health functional food and pharmaceutical compositions for the prevention and treatment of degenerative brain diseases including stroke and dementia (10-0950164 March 23, 2010), make-up having the ability to improve atopic dermatitis (10-1183893, September 12, 2012) and the like have been disclosed as development of functional products using various herbal preparations.
In recent years, as the extraction technology of herbal medicines has been developed and various formulation techniques have been developed, the medicinal properties of herbal medicines have been improved, easy to carry and palatability have been developed, and herbal medicines related products have been developed and popularized. Examples thereof include a process for producing chocolate containing concentrated herbal extracts (No. 10-0812826, Mar. 5, 2008) and chocolate herbal medicine and Ganache chocolate herbal medicine (No. 10-0769699, October 17, 2007) Is known.
The above-mentioned prior art and prior art are effective for antioxidation but have little antioxidative and immunological efficacy.
Accordingly, the present invention provides a method for producing a functional fermented sweet pot having antioxidative and immunological effects and a fermented sweet pot using the same.
In particular, the present invention is to provide a fermented sweet pot with a significant improvement in antioxidant and immunological effects by providing a sweet pot fermented by using a fermenting microorganism in a composition which is extracted by mixing herbal ingredients.
In order to solve the above problems and needs,
A process for preparing a composition which is prepared by mixing Sukjwangju, Veterinary Medicine, Astragalus membranaceus, Angelica gigas,
A process of inoculating L. elbruekii, L. acidophilus, L. casei, S. thermophilus or / and Yo-mix into the above-mentioned extracted composition to ferment,
Wherein the fermented sweet pot has an antioxidant activity and an immunological effect.
The present invention also provides a method for preparing an antioxidant and immunostimulating fermented sweet pot with antioxidative activity, characterized in that the composition is prepared by preparing a composition which is prepared by mixing a mixture of Sukjiro, .
The present invention also provides an antioxidant and immunostimulatory fermented sweet pot with a composition which is prepared by preparing a composition which is prepared by preparing a composition prepared by mixing Sukjungguk, Baekjaek, Cheonjung, and Angelica gigas .
The present invention also provides a fermented sweet pot produced by the above fermented sweet pot production method.
The fermented sweet pot produced by the fermented sweet pot according to the present invention exhibits a remarkable effect on antioxidation and immunological efficacy as compared with the conventional potted or extracted composition by mixing conventional herbal medicine with purified water.
In addition, the fermented samotang produced by the fermented sweet pot according to the present invention exhibits a remarkable effect on the anticancer efficacy and blood circulation function.
Brief Description of the Drawings Fig. 1 shows a comparison of the cytotoxicity of fermented sweet pot with the control group according to the present invention. Fig.
Hereinafter, the present invention will be described in detail.
The present invention provides a method for preparing fermented sweet pot with antioxidant and immunostimulating properties, which comprises a mixture of Sukjungguk, Baekjaek, Cheonjung, and Angelica gigas, and fermented sweet pot thereof.
The present invention also provides a method for preparing fermented sweet pot with antioxidative and immunomodulatory properties, which is obtained by mixing and extracting white pearl instead of the above-mentioned Sulfur and the fermented sweet pot.
That is, the present invention provides a method for producing fermented sweet pot with antioxidative and immunomodulatory effects, which comprises a composition obtained by mixing Baishuo, Baekjiao, Kaesung, and Angelicae, and fermented sweet pot thereof.
Also, the present invention provides a method for preparing fermented sweet pot with antioxidative and immunostimulatory properties and a fermented sweet pot using the composition, which is prepared by mixing and extracting the above-mentioned Sulfur Sulfur.
That is, the present invention provides a method for producing fermented sweet pot with antioxidative and immunostimulatory properties, and a fermented sweet pot using the composition, which comprises a composition obtained by mixing Baekjang medicine, Astragalus membranaceus and Angelica gigas.
The present invention has an optimum effect on antioxidative and immunological efficacy by mixing 50-150 parts by weight of Baekjang 50-150 parts by weight with 50-150 parts by weight of Angelica gigas on 100 parts by weight of Sulfuric acid.
In addition, the present invention has an optimum effect on antioxidative and immunological efficacy by mixing 50-150 parts by weight of Baekjunjae, 50-150 parts by weight of Angelica gigas, and 50-150 parts by weight of Angelica gigas on 100 parts by weight of white radish.
In addition, the present invention has an optimum effect on antioxidation and immunological efficacy by mixing 50 to 150 parts by weight of the above-mentioned bait, 50 to 150 parts by weight, and 50 to 150 parts by weight of Angelica gigas.
The above-mentioned Sukjihwang of the present invention means herbal medicines which are steamed and dried at the roots of Zhiwang (地黄).
Gwanghwang is a medicinal herb of perennial plant, and its roots are used as a medicinal material in one room. It is called raw persimmon, dried persimmon, and dried persimmon. Especially, it is called persimmon when it is soaked in steam and steamed and dried 9 times. The drug is the best. It has a bitter taste with a bitter taste, but it has a warm temperament, and it replenishes its blood and replenishes its essence (a substance that is fundamental to life and activity). It causes back and knee pain, sore symptoms, menstrual disorder, dizziness It has the efficacy to cure the head and darken the head.
The herbicide of the present invention means perennial herbaceous perennials of the dicotyledonous plants of the family Ranunculaceae.
It is also called river peony. It grows in deep mountains. It is 40 ~ 50cm in height. The roots are thick and fleshy, and the bottom is covered with scaly leaves. Leaves are 3 ~ 4 slices and split 3 ~ 2 times. The small leaf is long oval or the egg is turned upside down. The edge is flat and has no hair.
The flowers bloom in June and are 4 ~ 5cm in diameter and run one at the end of the main stem. Calyx is ovate, 3, petals are inverted, 5 ~ 7. There are several operations and three or four ovaries. Fruits are red and undersized red seeds and mature black seeds.
It has a hairy back on the back of the leaf (var.pilosa), a hair on the back of the leaf, a long style flower that grows backward and has a red flower (P.obovata) (povar.glabra). Roots are used for analgesia, gynecology, and women's diseases. It is distributed in Korea, Japan, China, Sakhalin islands.
The above-mentioned cichlid of the present invention means a perennial plant of the dicotyledonous decidua group.
It is a Chinese origin and cultivated as a medicinal plant. It is 30 ~ 60cm in height, hollow inside and branch slightly. Leaves are alternate, two-folded three-queen-folded compound leaf, and the forked pieces are egg-shaped, with a slightly deep sawtooth. The leaves of the root and the bottom have long petiole, and the lower part forms a sheath, wrapping the stem.
Flowers bloom from August to September, white and double-inflorescence. There are 5 petals and the inside is dry. There are 5 stamens and 1 pistil. The guns and the guns are 5 ~ 6 each in the shape of a line. The fruit is open but not mature. The nodules in the ground are like a lump of 5-10cm in length and 3-5cm in diameter and have a strong smell.
It has efficacy for sedation, analgesia, tonic, etc. and is used to treat headache, anemia, and women's diseases. Remove the leaves and stems from September to November, remove the stems, and dry them in the sun, then use 3 to 6g dalyeoseo, or use as a pill or powder.
The above-mentioned Angelica gigas of the present invention refers to dried root of Angelica gigas Nakai in Korea, mountain type and Angelica sinensis (Oliv.) Diels in China. In Japan, the roots of Angelica acutiloba (Siebold. & Zucc.) Kitag. Or Angelica acutiloba (Siebold. & Zucc.) Kitag. Var. Sugiyamae Hikino) are dried and used.
The above-mentioned Baik Soo of the present invention refers to dried root roots of Cynanchum wilfordii (Maximowicz J.D. Hooker) belonging to the subclass of Apocynaceae in Korea and North Korea, Asclepiadoideae.
The big mockery, the origin of the plant, is also known as the "white mulberry". It is a vine plant known as the "mockery", which grows on the grassy slopes of the mountainside or on the slopes of the beach. Harvest the roots from autumn to winter, then dry them and use them as medicine. The medicinal herb Sasso, known as the enemy Sasu, is originated from a plant called Fallopia multiflora (Thunberg) Haraldson and is a medicinal substance different from Hwaseoo.
It is a little bit warm and slightly warm (sweet and bitter). This medicinal medicine in the sense of the Chinese medicine to supplement the liver (肝肾) to strengthen the muscles and bones, digestive and good digestive function. Using this efficacy, it can be used for the treatment of gangrenous bladder (肝肾 虛 证), amblyopia (阳 证), yujung (遗 膝) , Diarrhea, when whiteheads fly faster than age, and when there is insufficient postpartum milk.
The technical feature of the present invention is that the fermented sweet pot is fermented by inoculating fermenting bacteria into an extract obtained by mixing the above raw materials, mixing purified water or water, and heating.
Fermented sweet pots fermented in this manner are characterized by remarkably different from the efficacy of a sweet potato extracted by simply mixing conventional raw materials and mixing with purified water or water, and especially characterized by remarkable antioxidative and immunological efficacy.
The present invention relates to a method for preparing a composition which is prepared by mixing Sukjungguk, Baekjaek, Cheonjung, and Angelica gigas (Type 1). (Step 1)
As described above, the present invention is a method for preparing a composition (Mixture 2), which is prepared by mixing Baechuo, Baekjaek, Cheonjung,
In addition, the present invention is a method for preparing a composition obtained by mixing Baekjak, Kaesung, and Angelicae minus Sukjunggul (type 3).
The composition may be extracted by heating the mixture with water, or using alcohol or reflux.
The mixing ratio of water in the composition should usually be about 3 to 20 times as much as the weight of the raw material, and when alcohol is used, the weight of the raw material should be about 1 to 20 times the weight of the raw material.
The present invention relates to a process for inoculating five kinds of microorganisms such as L.delbruekii, L. acidophilus, L. casei, S. thermophilus, and / or Yo-mix into the above-mentioned extracted composition of
The above-mentioned Yo-mix means a mixture of L.delbruekii, L. acidophilus and L. casei. The mixing ratio can be freely set and it is preferable to use an equal ratio.
That is, the process of fermenting each of the above-mentioned extracted compositions of
In addition, five kinds of bacteria such as L.delbruekii, L. acidophilus, L. casei, S. thermophilus and Yo-mix were mixed in each of the above-mentioned 1, 2, It means to carry out the process.
The mixing ratio can be freely set and it is preferable to use an equal ratio.
The above-mentioned fermentation process refers to a process of inoculating a bacterium and fermenting the bacterium at 30 to 40 degrees Celsius for about 20 to 138 hours.
The present invention can carry out the inoculation process and the fermentation process by mixing the above-mentioned 1, 2 or 3 type extracted composition with an additional composition effective for enhancing antioxidative and immunological efficacy.
The above-mentioned additional composition means a composition obtained by mixing 50-150 parts by weight of leek, 20-50 parts by weight of persimmon leaves, and 20-50 parts by weight of leather with 100 parts by weight of rosemary.
Particularly, in the above-mentioned additive composition, Leek refers to a perennial herb with a monocotyledonous plant lily.
The stem of the scales has a short rootstock underneath and a black-yellow fiber on the surface. Leaves are green, long, narrow and soft. A flower stalk, 30 to 40 cm long, grows between the leaves and forms a large umbrella flower at the end.
The leek of the present invention further functions to enhance antioxidative and immune functions.
It is effective to use the persimmon leaves as dried persimmon leaves.
The persimmon leaves function to enhance the immune function.
The above-mentioned leather of the present invention is an oddopharyngeal leaf having 13 to 25 small leaves and a wide bar egg shape. There is one or two pairs of large, dull mounts on the lower part of the leaf. Flowers bloom in June ~ July, bloomed in a circle of one hundred green and hang on the end of branch. Calyx is divided into 5 pieces with 5 petals and ends are dried inside. There are 10 stamens and 5 styles. Fruits are ripened in September - October, with long oval shape and wings on both sides of the seed.
It is preferable that the above-mentioned leather is dried by using a leaf taken from a leather tree.
The above-mentioned leather acts to enhance the antioxidative and immune functions in the fermented sweet pot of the present invention.
In the present invention, 20 to 30 parts by weight of the additive composition is very effective for antioxidation and immunity enhancement in 100 parts by weight of the above-mentioned 1, 2 or 3 type extracted composition.
The present invention can perform the inoculation process and the fermentation process by mixing the above-mentioned 1, 2, or 3 type extracted composition with a five sensory composition effective for improving the anticancer function and blood circulation.
The above-mentioned five-sensory composition of the present invention means a composition prepared by mixing a crude oil extract, xylitol, a phytoncide stock solution and an oligosaccharide.
The above-mentioned five-sensory composition means that 1 to 10 parts by weight of xylitol, 1 to 10 parts by weight of phytoncide stock solution and 50 to 80 parts by weight of oligosaccharide are mixed in 100 parts by weight of the extract of corn oil.
As mentioned above, the above-described extract of corn oil means that the ordinary corn oil is mixed with water, heated and extracted or extracted with alcohol.
In the present invention, mixing of 100 parts by weight of the above-mentioned extracted
In the present invention, a fermented sweet pot of
The method of extracting the above-described fermented sweet pot can be performed by a conventional extraction method or a rotary vacuum evaporator under reduced pressure.
The above-described 1, 2 or 3 type fermented sweet pot of the present invention has a very effective characteristic for antioxidation and immunity.
<Examples>
In the present invention, 30 g of the extract composition obtained by refluxing 5 g of Sukjiro, 5 g of Baekjongguk,
In addition, 5 g of white ginseng, 5 g of white ginseng, 5 g of ginseng root, and 5 g of Angelica grisea were placed in 200 g of purified water, and reflux extraction was conducted to prepare 30 g of the extract composition (type 2)
In addition, 5 g of Veterinary Medicine, 5 g of Angelicae radix and 5 g of Angelica gigantei were placed in 200 g of purified water and subjected to reflux extraction to prepare 30 g of the extract composition (type 3)
Five kinds of microorganisms such as L.delbruekii (A), L. acidophilus (B), L. casei (C), S. thermophilus (D) or Yo- mix (E) .
In addition, the extract composition was prepared by mixing 5 kinds of bacteria such as L.delbruekii (A), L. acidophilus (B), L. casei (C), S.thermophilus (D) (F) is inoculated and fermented.
The above fermented products were concentrated under reduced pressure on a rotary vacuum evaporator to obtain L. elebruekii (A), L. acidophilus (B), L . Five kinds of fermented sweet pots were fermented by inoculating them with 5 kinds of bacteria (Casei (C), S. thermophilus (D) or Yo-mix (E)
[Kind and name of fermented sweet potato obtained]
The concentrated solution of the fermented sweet potato obtained in the above 15 kinds was freeze-dried with a freeze dryer. The lyophilized sample was diluted in the third distilled water and used in the experiment.
<Experiment>
1) Antioxidant efficacy and 2) Immunity efficacy were measured for the fermented sweet pots obtained in the above 15 kinds obtained in the above Examples.
1. Antioxidant efficacy measurement
(1) Total phenol content measurement
0.5 ml of 50% Foiln-Ciocalteu's phenol reagent was added to 1 ml of each of the samples, and the mixture was reacted at room temperature for 3 minutes. 1 ml of saturated Na 2 CO 3 solution and 7.5 ml of distilled water were added to the reaction solution, and the mixture was allowed to stand for 30 minutes, followed by centrifugation at 12,000 rpm for 10 minutes. The supernatant was transferred to a 96-well plate and absorbance was measured at 760 nm. The total polyphenol content of the sample was determined according to the calibration curve prepared using gallic acid as a reference material. GAE (gallic acid equivalent) / g was used as a measurement unit.
The total phenol content of each sample was measured with gallic acid as a reference material. The results are shown in Table 1, which shows a very significant result because it contains a higher phenol content than Conrol (control).
(Where Samultang-1 means
Control indicates the case where the bacteria are not inoculated into the extract compositions of
L.delbruekii, L. acidophilus, L. casei, S.thermophilus or Yo-mix means obtained by inoculating and fermenting each of the bacteria into the 1, 2 and 3 type extract compositions.
Also, showing a significant result in the present invention means that the effect is higher than the control.
The same shall apply hereinafter)
2) Total flavonoid content measurement
Flavonoid content was measured by the method of Nieva Moreno et al. 10 ml of aluminum nitrate, 0.1 ml of 1M potassium acetate and 4.3 ml of 80% ethanol were added to 0.5 ml of a mixture of 0.1 ml of each sample and 0.9 ml of 80% ethanol, and the mixture was allowed to stand at room temperature for 40 minutes. The absorbance at 415 nm was measured. The content was determined from a standard curve using quercetin.
The total flavonoid content in each sample was measured using quercetin as a reference material as shown in [Table 2] and shows a very significant result as compared with Conrol (control).
3) Measurement of DPPH radical scavenging ability
Free radical scavenging activity test is a method using stable free radical DPPH. 150 μl of a 0.2 mM DPPH solution dissolved in ethanol and 100 μl of a sample at a concentration of 1, 10, 100, 1000 (μg / ml) were mixed and reacted at 37 ° C. for 30 minutes in a dark room. After the reaction, the absorbance was measured at 517 nm. In the control group, distilled water was added instead of the sample solution, and ethanol was added instead of the DPPH solution to obtain a correction value. The free radical scavenging rate was calculated according to (Equation 1) below.
(Equation 1)
(%) = [(Absorbance of control group - absorbance of sample addition group) / (absorbance of control group)] × 100
The effect of DPPH radical scavenging on each sample is shown in Table 3, which is very significant compared to the control group.
[DPPH Radical Scavenging Activity of Extracts from Samultang]
4) Measurement of ABTS radical scavenging ability
The ABTS assay method was modified for 96 well plates. ABTS solution was prepared by adding 7.4 mM ABTS (2,2-azino-bis- (3-ethylbenzothiazoline-6-sulfonic acid)) and 2.6 mM potassium persulphate. The absorbance at 734 nm was measured to determine the OD And the diluted ABTS + solution was mixed with the samples at concentrations of 1, 10, 100, and 1000 (ug / ml), reacted at room temperature for 10 minutes, and absorbance was measured at 734 nm. The antioxidative ability of the control group was determined by using the distilled water as a control, and the radical scavenging ability of the control group was expressed as a percentage as shown in the following formula (2).
(Equation 2)
(%) = [(1-absorbance of sample-added group) / (absorbance of control group)] x 100
The effect of DPPH radical scavenging on each sample is shown in Table 4, which is very significant compared to the control group.
5) Effect on ROS generation
RAW 264.7 cells were seeded at 2 × 10 5 cells / well in a 12-well plate. After culturing for 24 hours, each of the samples was treated with a concentration of 1, 10, 100 (㎍ / ml) and 1 μg / ml of LPS and cultured for 24 hours. After culturing, all cells were removed, and the collected cells were washed twice with cold PBS. 10 [mu] M of DCF-DA was added to the cells and stained in a 37 [deg.] C incubator for 15 minutes. After staining, the cells were washed with cold PBS, centrifuged at 1,200 rpm for 5 minutes, and the supernatant was removed. Then, 400 μl of PBS was added to suspend the supernatant. The changes of ROS production according to the intensity of fluorescence intensity were analyzed using flow cytometry analyzer.
The effect of ROS on the production of each sample is shown in Table 5, which is very significant compared to the control group.
* p < 0.05, ** p < 0.01, and *** p < 0.001
2. Measurement of immune efficacy
1) Measurement of immune related cytokine
RAW 264.7 Luminex was used to measure immune related cytokines in the cells. RAW 264.7 cells were plated at 5 x 10 < RTI ID = 0.0 >
1) IL-1?
The effect of IL-1β on the production of each sample is shown in Table 6, which is very significant compared to the control group.
* p < 0.05
2) IL-6
The effect of IL-6 on the production of each sample is shown in Table 7, which is very significant compared to the control group.
3) TNF -α
The effect of TNF-α on the production of each sample is shown in Table 8, which is very significant compared to the control group.
* p < 0.05, ** p < 0.01, and *** p < 0.001
2) Cytotoxicity measurement
RAW 264.7 cells were cultured in 96-well plates at 2 × 10 4 cells / well for 24 hours. After incubation, the medium was replaced with fresh medium. The samples were treated with 1 ㎍ / ㎖, 10 ㎍ / ㎖ and 100 ㎍ / ㎖ respectively and cultured again for 24 hours. After incubation, 10 μl of WST solution was added and reacted for 30 minutes in an incubator (37 ° C, 5% CO 2 ). After the reaction, the absorbance at 450 nm was measured and the cell survival rate of the control group was expressed as a percentage.
The cytotoxicity of each sample was as shown in FIG. 1, and the cytotoxicity was markedly lower than that of Control (control), showing a very significant result.
The present invention provides a method for producing fermented sweet pot with antioxidative and immunological properties and the fermented sweet pot with the above-described composition and function.
The present invention is very useful for industries that use herbs to produce, produce, process, distribute and research compositions having antioxidant and immunostimulatory properties.
Claims (4)
To the extracted composition, 100 parts by weight of rosemary is mixed with 50 to 150 parts by weight of leek, 20 to 50 parts by weight of persimmon leaves and 20 to 50 parts by weight of leather to prepare a mixed composition,
A step of inoculating L. elbruekii, L. acidophilus, L. casei or S. thermophilus into the above-mentioned mixed composition,
Wherein the fermented sweet pot has an antioxidant activity and an immunostimulating activity.
A method for preparing fermented sweet pot with antioxidant and immunostimulating properties, characterized in that the composition is prepared by preparing a composition prepared by mixing Sukjwangju, Baekjaejang, Cheonjung, and Angelicae, and preparing a composition prepared by mixing Baekgoo instead of Sukjunggi.
Wherein the composition is prepared by preparing a composition prepared by mixing Sukjwangju, Baekjaejak, Cheonjung, and Angelicae, except for Sukjwangjang.
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