KR101770006B1 - 체외 혈액 처리 중에 대용제의 공급을 조절하는 방법 및 대용제의 공급을 조절하기 위한 부재를 포함하는 체외 혈액 처리 장치 - Google Patents
체외 혈액 처리 중에 대용제의 공급을 조절하는 방법 및 대용제의 공급을 조절하기 위한 부재를 포함하는 체외 혈액 처리 장치 Download PDFInfo
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- KR101770006B1 KR101770006B1 KR1020127011574A KR20127011574A KR101770006B1 KR 101770006 B1 KR101770006 B1 KR 101770006B1 KR 1020127011574 A KR1020127011574 A KR 1020127011574A KR 20127011574 A KR20127011574 A KR 20127011574A KR 101770006 B1 KR101770006 B1 KR 101770006B1
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- Prior art keywords
- dialyzer
- flow resistance
- inter
- extracorporeal blood
- dependent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
-
- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1617—Control or regulation using measurements made during a temporary variation of a characteristic of the fresh dialysis fluid
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1635—Constructional aspects thereof with volume chamber balancing devices between used and fresh dialysis fluid
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- A—HUMAN NECESSITIES
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
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- A—HUMAN NECESSITIES
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
- A61M1/341—Regulation parameters by measuring the filtrate rate or volume
-
- A—HUMAN NECESSITIES
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3413—Diafiltration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3431—Substitution fluid path upstream of the filter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3431—Substitution fluid path upstream of the filter
- A61M1/3434—Substitution fluid path upstream of the filter with pre-dilution and post-dilution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
- A61M1/3635—Constructional details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/243—Dialysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/28—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/32—Controlling or regulating
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M2205/3327—Measuring
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01D2311/16—Flow or flux control
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Water Supply & Treatment (AREA)
- Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009055995.7 | 2009-11-26 | ||
| DE102009055995 | 2009-11-26 | ||
| PCT/EP2010/006981 WO2011063906A1 (de) | 2009-11-26 | 2010-11-16 | Verfahren zum regeln der zufuhr von substituat bei einer extrakorporalen blutbehandlung und extrakorporale blutbehandlungsvorrichtung mit einer einrichtung zum regeln der zufuhr von substituat |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20120117737A KR20120117737A (ko) | 2012-10-24 |
| KR101770006B1 true KR101770006B1 (ko) | 2017-08-21 |
Family
ID=43755229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127011574A Active KR101770006B1 (ko) | 2009-11-26 | 2010-11-16 | 체외 혈액 처리 중에 대용제의 공급을 조절하는 방법 및 대용제의 공급을 조절하기 위한 부재를 포함하는 체외 혈액 처리 장치 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11376353B2 (https=) |
| EP (1) | EP2504044B2 (https=) |
| JP (1) | JP5753538B2 (https=) |
| KR (1) | KR101770006B1 (https=) |
| CN (1) | CN102665791B (https=) |
| AU (1) | AU2010324153B2 (https=) |
| CA (1) | CA2778204C (https=) |
| ES (1) | ES2564104T5 (https=) |
| PL (1) | PL2504044T5 (https=) |
| WO (1) | WO2011063906A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011063906A1 (de) | 2009-11-26 | 2011-06-03 | Fresenius Medical Care Deutschland Gmbh | Verfahren zum regeln der zufuhr von substituat bei einer extrakorporalen blutbehandlung und extrakorporale blutbehandlungsvorrichtung mit einer einrichtung zum regeln der zufuhr von substituat |
| DE102011112221B4 (de) * | 2011-09-02 | 2017-05-24 | Fresenius Medical Care Deutschland Gmbh | Blutbehandlungsvorrichtung |
| DE102012004970A1 (de) * | 2012-03-14 | 2013-09-19 | Fresenius Medical Care Deutschland Gmbh | Verfahren zum Dosieren eines mittels einer Blutbehandlungsvorrichtung erzeugten Substituats sowie Vorrichtungen |
| DE102014008546B4 (de) * | 2014-06-16 | 2021-12-16 | Günter Heeke | Haemofiltrationsgerät, Schlauchset und dessen Verwendung und Verfahren zum Betrieb eines Haemofiltationsgeräts |
| EP3646336B1 (en) | 2017-06-28 | 2023-06-28 | Gambro Lundia AB | A system and a method for renal replacement therapy |
| CN113474019A (zh) | 2018-07-20 | 2021-10-01 | 费森尤斯医疗护理德国有限责任公司 | 中央控制式多患者透析治疗系统及其用途 |
| US11491267B2 (en) | 2018-07-27 | 2022-11-08 | Fresenius Medical Care Holdings, Inc. | Method for tailoring dialysis treatment based on sensed potassium concentration in blood serum or dialysate |
| DE102019124990A1 (de) | 2019-09-17 | 2021-03-18 | B.Braun Avitum Ag | Blutbehandlungsvorrichtung mit automatischer Verringerung einer Substitutionslösungsflussrate |
| US20230211057A1 (en) * | 2020-05-20 | 2023-07-06 | Nipro Corporation | Method of monitoring blood circulation, dialysis device, and non-transitory computer-readable storage medium |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020023880A1 (en) * | 2000-07-07 | 2002-02-28 | Luciano Pedrini | Method for the purification of blood by means of hemodialysis and/or hemofiltration and apparatus for performing said method |
| WO2008135193A1 (de) | 2007-05-04 | 2008-11-13 | Fresenius Medical Care Deutschland Gmbh | Verfahren und vorrichtung zur überwachung einer blutbehandelungseinheit einer extrakorporalen blutbehandlungsvorrichtung |
| WO2009080258A1 (de) | 2007-12-22 | 2009-07-02 | Fresenius Medical Care Deutschland Gmbh | Verfahren und vorrichtung zur bestimmung des transmembrandrucks bei einer extrakorporalen blutbehandlung |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3529973A1 (de) | 1985-08-22 | 1987-03-05 | Braun Melsungen Ag | Vorrichtung zur haemodiafiltration |
| DE3909967A1 (de) * | 1989-03-25 | 1990-09-27 | Fresenius Ag | Haemodialysegeraet mit automatischer einstellung des dialysierfluessigkeitsflusses |
| US5947689A (en) * | 1997-05-07 | 1999-09-07 | Scilog, Inc. | Automated, quantitative, system for filtration of liquids having a pump controller |
| EP1095666A1 (fr) * | 1999-10-29 | 2001-05-02 | Infomed S.A. | Dispositif d'épuration extracorporelle du sang |
| IT1320024B1 (it) | 2000-04-07 | 2003-11-12 | Gambro Dasco Spa | Metodo per la regolazione della infusione in una macchina di dialisi e macchina di dialisi per l'applicazione del citato metodo. |
| US6916424B2 (en) * | 2001-02-07 | 2005-07-12 | Nephros, Inc. | Method and apparatus for a hemodiafiltration delivery module |
| DE10115991C1 (de) | 2001-03-30 | 2002-04-18 | Fresenius Medical Care De Gmbh | Verfahren und Vorrichtung zum Erkennen von Stenosen in einem Schlauchleitungssystem |
| DE10159620C1 (de) | 2001-12-05 | 2003-08-14 | Fresenius Medical Care De Gmbh | Verfahren und Einrichtung zur Überwachung der Zufuhr von Substitutionsflüssigkeit während einer extrakorporalen Blutbehandlung |
| JP4373684B2 (ja) | 2003-02-19 | 2009-11-25 | 株式会社フィリップスエレクトロニクスジャパン | フィルタ目詰まり状況監視装置およびベッドサイドシステム |
| DE10355042B3 (de) | 2003-11-25 | 2005-06-23 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Vorrichtung zum Erkennen von Störungen des Blutflusses in einem extrakorporalen Blutkreislauf |
| DE102004023080B4 (de) * | 2004-05-11 | 2009-01-15 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Vorrichtung zur Überwachung der Zufuhr von Substitutionsflüssigkeit während einer extrakorporalen Blutbehandlung |
| DE102007052571A1 (de) | 2007-11-03 | 2009-05-07 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Vorrichtung zur Überwachung der Zufuhr von Substitutionsflüssigkeit während einer extrakorporalen Blutbehandlung |
| DE102008003714A1 (de) | 2008-01-09 | 2009-07-16 | Fresenius Medical Care Deutschland Gmbh | Verfahren zum Bestimmen des Anteils der Rezirkulation in einer Fistel und/oder der kardiopulmonalen Rezirkulation an der Summe von Fistelrezirkulation und kardiopulmonaler Rezirkulation |
| WO2011063906A1 (de) | 2009-11-26 | 2011-06-03 | Fresenius Medical Care Deutschland Gmbh | Verfahren zum regeln der zufuhr von substituat bei einer extrakorporalen blutbehandlung und extrakorporale blutbehandlungsvorrichtung mit einer einrichtung zum regeln der zufuhr von substituat |
| DE102011112221B4 (de) | 2011-09-02 | 2017-05-24 | Fresenius Medical Care Deutschland Gmbh | Blutbehandlungsvorrichtung |
-
2010
- 2010-11-16 WO PCT/EP2010/006981 patent/WO2011063906A1/de not_active Ceased
- 2010-11-16 US US13/512,133 patent/US11376353B2/en active Active
- 2010-11-16 ES ES10790889T patent/ES2564104T5/es active Active
- 2010-11-16 KR KR1020127011574A patent/KR101770006B1/ko active Active
- 2010-11-16 CA CA2778204A patent/CA2778204C/en active Active
- 2010-11-16 CN CN201080053450.7A patent/CN102665791B/zh active Active
- 2010-11-16 AU AU2010324153A patent/AU2010324153B2/en active Active
- 2010-11-16 JP JP2012540301A patent/JP5753538B2/ja active Active
- 2010-11-16 EP EP10790889.9A patent/EP2504044B2/de active Active
- 2010-11-16 PL PL10790889.9T patent/PL2504044T5/pl unknown
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2022
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020023880A1 (en) * | 2000-07-07 | 2002-02-28 | Luciano Pedrini | Method for the purification of blood by means of hemodialysis and/or hemofiltration and apparatus for performing said method |
| WO2008135193A1 (de) | 2007-05-04 | 2008-11-13 | Fresenius Medical Care Deutschland Gmbh | Verfahren und vorrichtung zur überwachung einer blutbehandelungseinheit einer extrakorporalen blutbehandlungsvorrichtung |
| WO2009080258A1 (de) | 2007-12-22 | 2009-07-02 | Fresenius Medical Care Deutschland Gmbh | Verfahren und vorrichtung zur bestimmung des transmembrandrucks bei einer extrakorporalen blutbehandlung |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120117737A (ko) | 2012-10-24 |
| US20120318739A1 (en) | 2012-12-20 |
| US11376353B2 (en) | 2022-07-05 |
| EP2504044A1 (de) | 2012-10-03 |
| PL2504044T3 (pl) | 2016-09-30 |
| CN102665791B (zh) | 2015-08-19 |
| CA2778204A1 (en) | 2011-06-03 |
| ES2564104T5 (es) | 2024-05-08 |
| ES2564104T3 (es) | 2016-03-17 |
| AU2010324153A1 (en) | 2012-07-12 |
| WO2011063906A1 (de) | 2011-06-03 |
| PL2504044T5 (pl) | 2024-11-18 |
| JP5753538B2 (ja) | 2015-07-22 |
| EP2504044B1 (de) | 2016-01-27 |
| US20220280707A1 (en) | 2022-09-08 |
| CA2778204C (en) | 2019-10-15 |
| AU2010324153B2 (en) | 2015-05-14 |
| JP2013512012A (ja) | 2013-04-11 |
| US12337093B2 (en) | 2025-06-24 |
| EP2504044B2 (de) | 2023-10-04 |
| CN102665791A (zh) | 2012-09-12 |
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