KR101738650B1 - 폴리이소부틸렌계 경피 패치의 연속 제조 방법 - Google Patents

폴리이소부틸렌계 경피 패치의 연속 제조 방법 Download PDF

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Publication number
KR101738650B1
KR101738650B1 KR1020127004362A KR20127004362A KR101738650B1 KR 101738650 B1 KR101738650 B1 KR 101738650B1 KR 1020127004362 A KR1020127004362 A KR 1020127004362A KR 20127004362 A KR20127004362 A KR 20127004362A KR 101738650 B1 KR101738650 B1 KR 101738650B1
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South Korea
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pib
molecular weight
average molecular
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Korean (ko)
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KR20120056830A (ko
Inventor
러셀 애덤 베어드
브라드 엘. 바네트
러셀 디. 베스티
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밀란 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J123/00—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers
    • C09J123/02—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers not modified by chemical after-treatment
    • C09J123/18—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms
    • C09J123/20—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms having four to nine carbon atoms
    • C09J123/22—Copolymers of isobutene; Butyl rubber ; Homo- or copolymers of other iso-olefines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/18—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms
    • C08L23/20—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms having four to nine carbon atoms
    • C08L23/22—Copolymers of isobutene; Butyl rubber; Homopolymers or copolymers of other iso-olefins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
    • C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
    • C08L2666/04—Macromolecular compounds according to groups C08L7/00 - C08L49/00, or C08L55/00 - C08L57/00; Derivatives thereof
    • C08L2666/06—Homopolymers or copolymers of unsaturated hydrocarbons; Derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Inorganic Chemistry (AREA)
  • Adhesives Or Adhesive Processes (AREA)
KR1020127004362A 2009-07-21 2010-07-19 폴리이소부틸렌계 경피 패치의 연속 제조 방법 Expired - Fee Related KR101738650B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27139809P 2009-07-21 2009-07-21
US61/271,398 2009-07-21
PCT/US2010/042428 WO2011011318A1 (en) 2009-07-21 2010-07-19 Process for the continuous manufacture of a polyisobutylene based transdermal patch

Publications (2)

Publication Number Publication Date
KR20120056830A KR20120056830A (ko) 2012-06-04
KR101738650B1 true KR101738650B1 (ko) 2017-05-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127004362A Expired - Fee Related KR101738650B1 (ko) 2009-07-21 2010-07-19 폴리이소부틸렌계 경피 패치의 연속 제조 방법

Country Status (13)

Country Link
US (2) US10632082B2 (enExample)
EP (1) EP2456839A1 (enExample)
JP (1) JP5887269B2 (enExample)
KR (1) KR101738650B1 (enExample)
CN (1) CN102597149A (enExample)
AU (1) AU2010276456B2 (enExample)
BR (1) BR112012001349B8 (enExample)
CA (1) CA2768646C (enExample)
IN (1) IN2012DN00845A (enExample)
MX (1) MX2012000947A (enExample)
NZ (1) NZ597993A (enExample)
RU (1) RU2541577C2 (enExample)
WO (1) WO2011011318A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012001349B8 (pt) * 2009-07-21 2021-05-25 Mylan Inc processo livre de solvente para produzir uma composição adesiva
CN102573721B (zh) * 2009-09-30 2015-09-09 莫恩里克保健公司 将把持条附着于膜敷料载体层上的方法
US20110200663A1 (en) * 2010-02-12 2011-08-18 Nitto Denko Corporation Methylphenidate patch preparation
JP2012067291A (ja) * 2010-08-27 2012-04-05 Nitto Denko Corp 非水系電池用粘着テープ
EP2599478A1 (de) 2011-11-30 2013-06-05 Acino AG Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff davon
US20130184351A1 (en) * 2011-12-21 2013-07-18 Jar Laboratories Lidocaine patch and methods of use thereof
US9072682B2 (en) 2012-12-31 2015-07-07 Mylan Inc. Transdermal dosage form for low-melting point active agent
EP3060214A2 (en) * 2013-10-21 2016-08-31 Florida State University Research Foundation Cns stimulant and opioid receptor antagonist combination as a non- addictive, non-aversive and synergistic anti-obesity treatment
CN106572981B (zh) 2014-07-04 2020-03-03 绿叶制药股份公司 用于制造药物贴剂的装置
US9650338B1 (en) 2016-07-29 2017-05-16 VDM Biochemicals, Inc. Opioid antagonist compounds and methods of making and using
WO2018155682A1 (ja) * 2017-02-27 2018-08-30 帝國製薬株式会社 リバスチグミン含有経皮吸収型製剤
USD999385S1 (en) 2021-10-18 2023-09-19 Dbv Technologies Patch assembly
USD999384S1 (en) 2021-10-18 2023-09-19 Dbv Technologies Patch assembly

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528392A (ja) * 2004-03-09 2007-10-11 マイラン・テクノロジーズ・インコーポレーテッド 薬物送達を修飾するための、多層接着剤マトリックスを含有する経皮系

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US736992A (en) * 1902-08-16 1903-08-25 William E Messacar Combined awning and window-shade.
US3634381A (en) * 1968-04-27 1972-01-11 Basf Ag Degradation of high molecular weight polyisobutylene in extruders
JPS591180B2 (ja) 1978-11-07 1984-01-10 東燃石油化学株式会社 コ−トハンガ−ダイ
US4559222A (en) 1983-05-04 1985-12-17 Alza Corporation Matrix composition for transdermal therapeutic system
AU622162B2 (en) * 1988-04-22 1992-04-02 Ciba-Geigy Ag Transdermal monolith systems
US5508038A (en) 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
CA2075517C (en) 1992-04-01 1997-03-11 John Wick Transdermal patch incorporating a polymer film incorporated with an active agent
US5704555A (en) * 1993-08-02 1998-01-06 Illinois Institute Of Technology Single-screw extruder for solid state shear extrusion pulverization and method
JPH0873694A (ja) * 1994-09-02 1996-03-19 Mitsubishi Chem Corp 塗装性樹脂組成物成形体
US6248378B1 (en) * 1998-12-16 2001-06-19 Universidad De Sevilla Enhanced food products
US6365178B1 (en) 1996-09-06 2002-04-02 Watson Pharmaceuticals, Inc. Method of making pressure sensitive adhesive matrix patches for transdermal drug delivery using hydrophilic salts of drugs and hydrophobic pressure sensitive adhesive dispersions
US5830811A (en) * 1997-03-18 1998-11-03 Alliedsignal Inc. Load leveling yarns and webbings
DE19918106A1 (de) * 1999-04-22 2000-10-26 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit neutralisierten Acrylathaftklebern
DE10001546A1 (de) * 2000-01-14 2001-07-19 Beiersdorf Ag Verfahren zur kontinuierlichen Herstellung und Beschichtung von Selbstlebemassen auf Basis von Polyisobutylen mit mindestens einem pharmazeutischen Wirkstoff
SI1296689T1 (sl) * 2000-06-20 2006-08-31 Novartis Ag Nacin dajanja pacientu bisfosfonatov
DE10056010A1 (de) * 2000-11-11 2002-05-16 Beiersdorf Ag Pflaster mit hautpflegenden Substanzen
DE10141651B4 (de) * 2001-08-24 2007-02-15 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung
CN100542533C (zh) * 2004-08-12 2009-09-23 日东电工株式会社 包含芬太尼的粘合剂制剂
BR112012001349B8 (pt) * 2009-07-21 2021-05-25 Mylan Inc processo livre de solvente para produzir uma composição adesiva

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528392A (ja) * 2004-03-09 2007-10-11 マイラン・テクノロジーズ・インコーポレーテッド 薬物送達を修飾するための、多層接着剤マトリックスを含有する経皮系

Also Published As

Publication number Publication date
CN102597149A (zh) 2012-07-18
KR20120056830A (ko) 2012-06-04
CA2768646C (en) 2014-07-08
CA2768646A1 (en) 2011-01-27
MX2012000947A (es) 2012-02-29
NZ597993A (en) 2013-06-28
RU2012106117A (ru) 2013-08-27
US20110020426A1 (en) 2011-01-27
BR112012001349B1 (pt) 2020-10-27
BR112012001349A2 (pt) 2017-07-11
RU2541577C2 (ru) 2015-02-20
BR112012001349B8 (pt) 2021-05-25
US20200253886A1 (en) 2020-08-13
AU2010276456A1 (en) 2012-03-01
IN2012DN00845A (enExample) 2015-06-26
EP2456839A1 (en) 2012-05-30
AU2010276456B2 (en) 2014-07-03
WO2011011318A8 (en) 2011-08-18
JP2012533632A (ja) 2012-12-27
US11911522B2 (en) 2024-02-27
US10632082B2 (en) 2020-04-28
JP5887269B2 (ja) 2016-03-16
WO2011011318A1 (en) 2011-01-27

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