KR101729139B1 - Hydrogel Pad containing Natural Materials - Google Patents

Abstract

A hydrogel pad for skin treatment comprising one or more natural ingredients selected from the group consisting of a red algae-derived polysaccharide, a mannose-containing polysaccharide and a natural gum is disclosed. The hydrogel pads of the present invention are excellent in feeling on the skin and cooling effect. In addition, there is an advantage that the stimulation to the skin can be prevented and the treatment effect can be improved when the skin is treated for cosmetic or therapeutic purposes.

Hydrogel, laser procedure, cooling, moisturizing, skin irritation relief

Description

Hydrogel pads containing natural ingredients {Hydrogel Pad containing Natural Materials}

The present invention relates to a hydrogel pad comprising a natural component.

Conventionally, a variety of sheet-type pads made of acrylic or silicone have been commercialized for cosmetic and cosmetic purposes, but they have not been designed to meet laser treatment or other medical purposes. When a conventional acrylic polymer is used as the main raw material, there is an advantage in that it can increase the strength and feel of use of the material, but there is a possibility that the synthetic polymer is adversely reacted or denatured by the laser.

In particular, when an acrylic polymer is used, there is a concern that irritation may be caused to the skin due to a small amount of unreacted polymer that may exist after the polymer reaction. In addition, when an acrylic polymer is used, the thickness of the hydrogel pad itself becomes thick, so that the skin adhesion force is reduced at the bending portion of the face, and the effect of the laser treatment can be reduced.

It is an object of one embodiment of the present invention to provide a hydrogel pad which is excellent in feeling during use for cosmetic or therapeutic purposes on the skin and can improve the treatment effect.

The hydrogel pad according to the present invention comprises at least one natural ingredient selected from the group consisting of a red algae-derived polysaccharide, a mannose-containing polysaccharide and a natural gum, and is characterized in that it is used in skin surgery, for example, laser surgery.

The hydrogel pads according to the present invention are excellent in feeling on the skin and cooling effect. In addition, there is an advantage that the stimulation to the skin can be prevented and the treatment effect can be improved when the skin is treated for cosmetic or therapeutic purposes. The pad can be used as a skin-protecting pad when treating the skin, and can be used variously in the field of skin care and treatment.

The hydrogel pads according to one embodiment of the present invention include one or more natural ingredients selected from red seaweed polysaccharides, manose containing polysaccharides and natural gums. The natural ingredients contained in the hydrogel pads according to the present invention are not particularly limited. For example, the red algae-derived polysaccharide may be at least one selected from the group consisting of carrageenan, agar and agarose. In addition, the mannose-containing polysaccharide may be one or more selected from the group consisting of mannan, galactomannan, glucomannan and derivatives thereof. Natural gums include, for example, locust bean gum, guar gum, xanthan gum, Arabic gum, gellan gum and karaya gums. gum). < / RTI >

In one embodiment, the content of the red algae-derived polysaccharide may be 0.1 to 20% by weight, specifically 1 to 5% by weight, based on the total weight of the hydrogel pad. The content of the mannose-containing polysaccharide may be 0.1 to 20% by weight, specifically 1 to 5% by weight, based on the total weight of the hydrogel pad. The content of the natural gums may be 0.1 to 20% by weight, specifically 1 to 5% by weight, based on the total weight of the hydrogel pads. In another embodiment, the content of the natural component comprising the red algae-derived polysaccharide, the mannose-containing polysaccharide and the natural gum is from 0.1 to 60% by weight, in particular from 1 to 15% by weight, based on the total weight of the hydrogel pad . The content of the natural ingredients is intended to provide transparency of the hydrogel pad and to maintain its shape in a certain form, while at the same time improving the skin cooling effect.

In the case of gel preparations using a conventional synthetic polymer, there is a possibility that an abnormal reaction or denaturation may be caused by irradiation of a laser. In particular, in the case of a gel preparation using an acryl-based polymer, skin irritation may be caused due to the remaining unreacted polymer.

The hydrogel pads according to the embodiment of the present invention do not cause the above problems because natural polymers are used. In particular, when skin beauty treatment using a laser is performed, the skin can be protected from heat and the treatment effect can be improved There are advantages. In one embodiment, the hydrogel pads can be utilized as pads for skin procedures.

The term " for skin treatment " of the present invention means that it can be used in a cosmetic or therapeutic treatment process for skin, and includes a concept used for relieving irritation, cooling, alleviating pain and improving treatment effect. For example, a hydrogel pad for skin treatment refers to a hydrogel pad used to protect the skin during a cosmetic or therapeutic treatment procedure for the skin.

The term " hydrogel " of the present invention means a gel produced by using water or a component containing water as a dispersion medium.

In one embodiment, the skin procedure may be a laser procedure. Laser procedures include laser ablation or use of other lasers to excite the skin or stimulate the skin with high energy. The hydrogel pad according to the present invention absorbs the instantaneous heat generated by the laser irradiation by the gel pad itself, thereby providing a substantial effect on calming the skin. In addition, it has an effect of preventing skin burns from erythema of the skin or other heat, giving a refreshing feeling to the skin, and reducing the procedure pain itself due to the cooling effect.

For use as a laser treatment pad, transparency or high transmittance is required. In one embodiment, the permeability of the hydrogel pad is at least 95%, more specifically at least 98%. When the permeability of the hydrogel pad satisfies the above range, it exhibits a high transmittance, so that scattering of the transmitted laser is small, thereby preventing energy loss and preventing the temperature rise of the hydrogel pad caused by scattering .

The hydrogel pads according to the present invention can be used for protecting the skin during the skin cosmetic treatment. In one embodiment, the hydrogel pad is characterized by cooling the skin temperature by 4 ° C or more, specifically 5 ° C or more when attached to the skin. In another embodiment, the hydrogel pad is characterized in that the skin temperature is cooled to 3 to 10 캜, specifically 4 to 6 캜. The hydrogel pad lowers the skin temperature instantaneously, thereby protecting the skin from irritation which may be caused during cosmetic procedures such as laser surgery or tattoo removal.

In one embodiment, the hydrogel pads may further comprise a metal salt. The metal salt serves to form a gel structure through chemical cross-linking with the polymer contained in the gel preparation. The metal salt may be, for example, sodium alginate, ammonium alginate, potassium alginate, calcium alginate, propylene glycol alginate, sodium carboxymethylcellulose, carboxymethylcellulose calcium, sodium carboxymethylstarch, sodium caseinate and aluminum glycinate And may be one or more selected from the group consisting of.

In another embodiment, the hydrogel pad may further comprise at least one polyol selected from the group consisting of glycerin, butylene glycol and propylene glycol. In addition, a moisturizing agent such as hyaluronic acid or beta-glucan may be further contained. The polyol or the moisturizing agent serves to increase the moisture resistance or water content of the hydrogel formulation. For example, in order to absorb the instantaneous heat generated in the laser treatment by the gel pad to protect the skin, excellent moisture resistance or a high moisture content is required.

In one embodiment, the water content of the hydrogel pads may be from 50 to 90% by weight, based on the total weight of the pad. In order to enhance the instantaneous cooling effect of the skin and prevent the secondary damage by the high energy of the laser, a high water content is required. If the water content is lower than the above range, the stability, cooling effect and water supply ability of the hydrogel pad may be deteriorated. Further, when the gel pad contains an appropriate moisturizing agent and water, it can be used as an agent for removing keratin substances which may deteriorate the treatment effect by the moisturizing agent and water contained.

In one embodiment, the thickness of the hydrogel pads is 1 to 20 mm, more specifically 1 to 6 mm. This range is intended to maintain the cooling efficiency for a long time. In addition, when the thickness is within the above range, the buffering effect can be obtained even when the intensity of the laser is high, and the scattering phenomenon of the laser can be prevented, and the accuracy of the procedure can be improved.

In another embodiment, the strength of the hydrogel pads is 1 to 1000 gf / cm ² , more specifically 10 to 100 gf / cm ² . When the gel pad has a strength of less than 1 gf / cm ² , there is a high possibility that gel damage caused by the laser electrode and deviation of the procedure due to the laser electrode are increased. When the gel pad strength is more than 1000 gf / cm ² , The accuracy of the procedure and feeling of use (comfort) are lowered.

Hereinafter, the present invention will be described in further detail with reference to examples. However, the following examples are intended to illustrate the present invention and the scope of the present invention is not limited thereto.

[Example 1]

2% of Aga (Japanese puree) and 2% of manna were dispersed in purified water, and then 30% of glycerin was dispersed and mixed. Then, 2% of hyaluronic acid and 2% of beta-glucan were added to adjust the viscosity, and a hydrogel pad was prepared to a thickness of 3 mm.

[Example 2]

2% of carrageenan and 1% of sodium alginate (Japanese noodles) were dispersed in purified water, and then 30% of glycerin was dispersed and mixed. Then, 2% of hyaluronic acid and 2% of beta-glucan were added to adjust the viscosity, and then a hydrogel pad having a thickness of 3 mm was prepared.

[Example 3]

1.2% of locust bean gum (National Starch / USA) and 2% of agar were dispersed in purified water, and then 30% of glycerin was dispersed and mixed. Then, 2% of hyaluronic acid and 2% of beta-glucan were added to adjust the viscosity, and a hydrogel pad was prepared to a thickness of 3 mm.

[Example 4]

2% of agar (Japanese puree) and 2% of manna were dispersed in purified water, and then 30% of glycerin was dispersed and mixed. Then, 2% of hyaluronic acid and 2% of beta-glucan were added to adjust the viscosity, and then a gel pad having a thickness of 0.9 mm was prepared.

[Example 5]

2% of agar (Japanese puree) and 2% of manna were dispersed in purified water, and then 30% of glycerin was dispersed and mixed. Then, 2% of hyaluronic acid and 2% of betaglucan were added to adjust the viscosity, and a gel pad having a thickness of 40 mm was prepared.

[Example 6]

1.5%, 1.5%, and 1.0% of locust bean gum (National Starch / USA) were dispersed in purified water, and then 30% of glycerin was dispersed and mixed. Then, 2% of hyaluronic acid and 2% of beta-glucan were added to adjust the viscosity, and then a gel pad having a thickness of 5 mm was prepared.

[Comparative Example 1]

2 g of agarose was dissolved in 50 mg of purified water at 100 캜 and then cooled to 60 캜. Then, 60 mg of N, N, N ', N'-tetramethylenediamine (TEMED) and 45 mg of ammonium peroxydisulfate Respectively. To the mixed solution, an acrylamide solution in which 3.5 g of acrylamide and 0.1 g of N, N'-methylene-bis-acrylamide were dissolved in 50 ml of purified water was continuously mixed to prepare a hydrogel pad having a thickness of 3 mm.

[Experimental Example 1] Skin irritation experiment

To investigate the degree of skin irritation in hydrogel pad formulations, 30 skin test subjects were randomly assigned to 30 adult women with an average age of 31.2 years. The hydrogel pads used in the experiments were those prepared in Examples 1 to 3 and Comparative Example 1.

In the experimental method, the four kinds of hydrogel pads were attached, and 48 hours after the removal of the hydrogel pads, the first reading was performed 30 minutes later, and the second reading was performed after 96 hours. As a positive control, 0.5% SLS (sodium losuryl sulfate) solution was used.

In order to confirm the skin irritation intensity of each sample, weights were given according to the degree of positive skin reaction, and the average skin response was determined to determine the skin irritation of the sample. The experimental results are shown in Table 1 below.

No name Example 1 Example 2 Example 3 Comparative Example 1 48h 96h 48h 96h 48h 96h 48h 96h One Subject-1 - - - - - - - - 2 Subject-2 - - - - - - One - 3 Subject-3 - - - - - - One - 4 Subject-4 - - - - - - - - 5 Subject -5 - - - - - - - - 6 Subject-6 - - - - - - One - 7 Subject -7 - - - - - - One - 8 Subject-8 - - - - - - - - 9 Subject-9 - - - - - - - - 10 Subject-10 - - - - - - - - 11 Subject-11 - - - - - - - - 12 Subject -12 - - - - - - - - 13 Subject -13 - - - - - - 2 One 14 Subject-14 - - - - - - - - 15 Subject -15 - - - - - - - - 16 Subject -16 - - - - - - - - 17 Subjects -17 - - - - - - - - 18 Subject-18 - - - - - - One One 19 Subjects -19 - - - - - - - - 20 Subject -20 - - - - - - - - 21 Subject -21 - - - - - - - - 22 Subject -22 - - - - - - One - 23 Subject-23 - - - - - - - - 24 Subject -24 - - - - - - - - 25 Subject -25 - - - - - - One - 26 Subject-26 - - - - - - - - 27 Subject -27 - - - - - - One - 28 Subject -28 - - - - - - - - 29 Subject-29 - - - - - - - - 30 Subject -30 - - - - - - One -

Referring to Table 1, in the case of the hydrogel pads made of natural materials (Examples 1 to 3) as a result of the primary reading, skin irritation did not occur, but hydrogel pads containing an acrylic polymer (Comparative Example 1) After 48 hours, 33.3% of the primary irritation (erythema) occurred and in two of them, the skin irritation remained even after 96 hours.

[Experimental Example 2] Physical properties and laser treatment effect according to thickness of hydrogel pads

In order to confirm the relationship between the thickness of the hydrogel pad and the laser transmittance, the thickness of the hydrogel pad, the laser transmittance and the effect of the laser treatment were evaluated in 30 yellow laser treatment groups.

We performed two laser treatments for one month. We compared the therapeutic effect of hydrogel pads and laser treated patients. The evaluation results are shown in Table 2 below.

Example 1 Example 4 Example 5 Treatment effect
(Hydrogel pads
Comparison with unattached areas) Same Same 20-30% reduction Laser transmittance 98.04% 98.29% 79.10% Hydrogel strength 25 gf / cm ² 0.9 gf / cm ² 1100 gf / cm ² Ease of use (practitioner) Good When the procedure breaks the pad
Tearing occurred The pad must be removed from the skin and the operator must hold it.

Referring to Table 2, when the thickness of the hydrogel pad is thinner than 1 mm (Example 4), the difference in the effect of the treatment is not great, but there is a problem in use such as tearing of the pad during the procedure. On the contrary, in the case where the thickness of the hydrogel pad is large (Example 5), there is a problem that the adhesive force of the pad is lowered and a phenomenon of spot spreading occurs during the laser procedure, thereby reducing the effect of the treatment.

As shown in FIG. 1, the hydrogel pads of Example 1 have a larger difference in laser transmittance than the hydrogel of Example 4, which is relatively thin, in comparison with the hydrogel pads according to the thickness of the hydrogel pads Respectively. However, in the hydrogel pads of Example 5 in which the thickness of the pads is relatively thick, the laser transmittance is remarkably lowered and falls to less than 80%.

In addition, the feeling of the patient, the satisfaction of the result, and the utility evaluation of the practitioner during the treatment were confirmed for the hydrogel pad of Example 1, and the results are summarized in Table 3 below.

Reduced pain Reduced heat sensitivity comfort Very good 22 people 10 people 5 people Excellent 8 people 18 people 19 people good - 2 people 4 people usually - - 2 people Poor - - -

Referring to Table 3, it was confirmed that the hydrogel pad of Example 1 according to an embodiment of the present invention can very effectively remove the pain and heat generated during the procedure.

[Experimental Example 3] Cooling effect of hydrogel pads

The cooling effects of the hydrogel pads of Examples 1 to 3 were measured. The subjects were rested for 1 hour in the thermostatic chamber before measurement, and the hydrogel pads of Examples 1 to 3 were attached to one of the balls and not attached to the other of the balls. The skin temperature was measured using an infrared thermometer at an elapsed time of one hour. The measurement results are shown in Table 4 below. Further, Figs. 2 to 4 are photographs of skin temperature images taken using an infrared thermometer at a point of time 1 hour after attachment of the hydrogel pads of Examples 1 to 3.

Example 1 Example 2 Example 3 Pad not attached (℃) 37.5 36.4 35.5 With pad (℃) 32.1 32.3 31.2 Temperature change per hour (° C / hr) 5.4 4.1 4.3

Referring to Table 2 and FIGS. 2 to 4, it can be seen that when the hydrogel pads of Examples 1 to 3 are applied, the skin temperature is lowered by 4 ° C or more, and this effect is maintained even after one hour. From these results, it can be seen that the hydrogel pad according to an embodiment of the present invention sufficiently blocks the heat generated by the laser when the skin cosmetic or treatment laser is performed, effectively restraining the patient's pain due to heat .

In addition, various types of hydrogel pads were prepared according to the following composition. In the following Formulation Examples 1 to 6, hydrogel pads were prepared in the same manner as in Example 1, by mixing the components described in Tables 5 to 10, respectively.

[Formulation Example 1]

Hydrogel pads were prepared by mixing the ingredients described in Table 5 below.

ingredient content Carrageenan 5.0% Met 2.5% Locust bean gum 5.0% Beta-glucan 2.0% Disodium iodide 0.02% Phenoxyethanol 0.3% glycerin 3.0% Butylene glycol 3.0% Purified water To 100%

[Formulation Example 2]

Hydrogel pads were prepared by mixing the ingredients described in Table 6 below.

ingredient content Baby 1.5% Met 5.0% Guar gum 2.0% Beta-glucan 2.0% Disodium iodide 0.02% Phenoxyethanol 0.3% glycerin 5.0% Butylene glycol 3.0% Purified water To 100%

[Formulation Example 3]

The hydrogel pads were prepared by mixing the ingredients described in Table 7 below.

ingredient content Agarose 2.0% Met 7.2% Xanthan gum 0.3% Beta-glucan 2.0% Disodium iodide 0.02% Phenoxyethanol 0.3% glycerin 5.0% Butylene glycol 3.0% Purified water To 100%

[Formulation Example 4]

Hydrogel pads were prepared by mixing the ingredients described in Table 8 below.

ingredient content Baby 10.0% Met 5.0% Arabian sword 1.0% Beta-glucan 5.0% Disodium iodide 0.02% Phenoxyethanol 0.3% glycerin 3.0% Butylene glycol 3.0% Purified water To 100%

[Formulation Example 5]

The hydrogel pads were prepared by mixing the ingredients described in Table 9 below.

ingredient content Baby 2.0% Met 5.3% Gellan gum 3.7% Disodium iodide 0.02% Phenoxyethanol 0.3% glycerin 3.0% Butylene glycol 3.0% Beta-glucan 5.0% Purified water To 100%

[Formulation Example 6]

The hydrogel pads were prepared by mixing the ingredients described in Table 10 below.

ingredient content Baby 1.0% Met 1.0% Kara-Sword 15.0% Disodium iodide 0.02% Phenoxyethanol 0.3% glycerin 3.0% Butylene glycol 3.0% Beta-glucan 5.0% Purified water To 100%

1 is a graph showing laser transmittance according to the thickness of a hydrogel pad;

FIGS. 2 to 4 are photographs of the skin temperature taken using an infrared thermometer after attaching the hydrogel pad according to one embodiment.

Claims (14)

Wherein the skin has a thickness of 1 to 20 mm, an intensity of 1 to 1000 gf / cm ² , and a skin adhesion to the skin And the skin temperature is cooled by 4 ° C or more compared to before attachment. The method according to claim 1, Wherein the red algae-derived polysaccharide is at least one selected from the group consisting of carrageenan, agar, and agarose. The method according to claim 1, Wherein the mannose-containing polysaccharide is at least one selected from the group consisting of mannan, galactomannan, glucomannan, and derivatives thereof. The method according to claim 1, Wherein the natural black locust is at least one selected from the group consisting of brown bean gum, guar gum, xanthan gum, gum arabic, gellan gum and karaya gum. The method according to claim 1, And 0.1 to 20% by weight, based on the total weight of the pad, of at least one natural ingredient selected from the group consisting of the red algae-derived polysaccharide, the mannose-containing polysaccharide and the natural gum. The method according to claim 1, The hydrogel pad has a laser transmittance of 95% or more. delete 7. The method according to any one of claims 1 to 6, Wherein the hydrogel pad is selected from the group consisting of sodium alginate, ammonium alginate, potassium alginate, calcium alginate, propylene glycol alginate, carboxymethylcellulose sodium, carboxymethylcellulose calcium, carboxymethylstarch sodium, casein sodium and aluminum glycinate ≪ / RTI > further comprising at least one metal salt. 7. The method according to any one of claims 1 to 6, Wherein the hydrogel pad further comprises at least one polyol selected from the group consisting of glycerin, butylene glycol, and propylene glycol. 7. The method according to any one of claims 1 to 6, The hydrogel pad has a water content of 50 to 90 wt% based on the total weight of the pad. delete delete The method according to claim 1, Wherein the hydrogel pad is a skin treatment pad. 14. The method of claim 13, Wherein the skin treatment is a laser treatment.

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