CN116869845A - Relief repair composition, relief repair freeze-dried mask and preparation method of relief repair freeze-dried mask - Google Patents
Relief repair composition, relief repair freeze-dried mask and preparation method of relief repair freeze-dried mask Download PDFInfo
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- CN116869845A CN116869845A CN202310954759.2A CN202310954759A CN116869845A CN 116869845 A CN116869845 A CN 116869845A CN 202310954759 A CN202310954759 A CN 202310954759A CN 116869845 A CN116869845 A CN 116869845A
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- soothing
- repairing
- freeze
- mask
- parts
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- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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Abstract
The invention discloses a soothing and repairing composition, a soothing and repairing freeze-dried mask and a preparation method thereof, and relates to the technical field of skin care products. The soothing and repairing composition comprises the following components in parts by weight: 0.05-0.15 part of acetyl hydroxyproline, 0.05-0.15 part of blue copper peptide, 0.05-0.4 part of hydroxy asiaticoside, 0.5-2 parts of allantoin, 1-2 parts of dipotassium glycyrrhizinate and 0.05-0.15 part of pH regulator. The soothing and repairing freeze-dried mask prepared from the composition has good soothing and repairing effects and can improve sensitive muscles.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to a soothing and repairing composition, a soothing and repairing freeze-dried mask and a preparation method thereof.
Background
Sensitive skin has thin horny layer, and is easy to appear reddish, fever, itching, stinging and other symptoms when stimulated by the outside, and red swelling and rash can appear when severe. The existing cosmetics on the market contain additives, so that the skin is greatly stimulated, the effect of improving the skin state cannot be achieved due to improper use, and the resistance of the skin can be further reduced. Therefore, it is highly desirable to provide a skin care product which is less irritating and suitable for sensitive muscles.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a soothing and repairing composition, a soothing and repairing freeze-dried mask and a preparation method thereof; the soothing and repairing composition and the soothing and repairing freeze-dried mask are suitable for sensitive muscles, can improve skin states and establish natural skin barriers.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a soothing composition comprising the following ingredients in parts by weight: 0.05-0.15 part of acetyl hydroxyproline, 0.05-0.15 part of blue copper peptide, 0.05-0.4 part of hydroxy asiaticoside, 0.5-2 parts of allantoin, 1-2 parts of dipotassium glycyrrhizinate and 0.05-0.15 part of pH regulator.
Acetyl hydroxyproline can promote synthesis of ceramide, improve skin barrier, increase skin moisture, relieve skin itching, has anti-inflammatory effect, promote fibroblast proliferation, and increase collagen synthesis; the blue copper peptide can promote the generation of collagen and elastin, reduce the generation of scar tissue and stimulate the self healing of skin; the madecassoside can promote proliferation of human fibroblasts, and has good effect of repairing damaged skin; allantoin has antibacterial, antiseptic, analgesic, and antioxidant effects, and can keep skin moist and soft, relieve and treat xerosis cutis, promote cell growth, soften keratin, etc.; dipotassium glycyrrhizinate can prevent skin rash and dry skin, and can be used for resisting allergy; the acidity of acetylhydroxyproline is strong, and the acetylhydroxyproline is adjusted to be neutral by adding a pH regulator. The preparation method provided by the invention has the advantages that the components are selected and compounded, and the prepared soothing and repairing composition can synergistically improve the skin state, has a good soothing and repairing effect, and is suitable for sensitive muscles.
Preferably, the soothing and repairing composition further comprises 0.86-2.2 parts of glucosyl, which is a cell activator having the effects of resisting oxidation, aging and repairing cells. By adding the glucosyl glycoside to the soothing composition, the moisturizing effect and the soothing effect of the composition can be further improved.
Further preferably, the soothing and repairing composition further comprises 0.45-2.2 parts of beta-glucan, wherein the beta-glucan can relieve skin inflammation, stabilize skin state, repair damaged skin and increase skin elasticity. Beta-glucan can cooperate with acetyl hydroxyproline, blue copper peptide, madecassoside, allantoin, dipotassium glycyrrhizinate and glyceroglycoside in the composition for relieving and repairing, so that the skin relieving and repairing functions of the composition are obviously improved.
Meanwhile, the invention also provides a soothing and repairing freeze-dried mask, which contains the soothing and repairing composition.
Preferably, the soothing and repairing freeze-dried mask also comprises 0.1-1 part of butanediol, 0.6-0.9 part of sodium hyaluronate, 0.2-0.3 part of alcaligenes polysaccharide, 0.5-0.6 part of hydrolyzed sclerotium rolfsii, 3-8.45 parts of betaine, 0.05-0.15 part of centella asiatica extract, 0.5-1.5 part of schizophyllan and 0.1-0.8 part of preservative.
The three components of sodium hyaluronate, alcaligenes polysaccharide and hydrolyzed sclerotium rolfsii are selected as the thickening agent, the proportion of the three components is selected, and the molecular weight of the sodium hyaluronate is 800000 ～ 1500000Da, so that the film forming property can be improved, and the mask with good use performance can be prepared. Butanediol and betaine have moisturizing effect, and centella asiatica extract and schizophyllan are skin conditioning agents. The facial mask prepared by the components has good formability and good moisturizing and repairing effects.
Preferably, the preservative is at least one of hexanediol and p-hydroxyacetophenone, and the soothing and repairing freeze-dried mask also contains 0.01-0.1 part of colorant, such as gardenia extract and the like.
In addition, the invention also discloses a preparation method of the soothing and repairing freeze-dried mask, which comprises the following steps:
(1) Weighing water, butanediol, sodium hyaluronate, alcaligenes polysaccharide, hydrolyzed sclerotium gum, betaine and allantoin according to a proportion, stirring and mixing at 80-88 ℃, stirring until no obvious particles exist, and preserving heat for 20-40 min to obtain a mixture A;
(2) Cooling the mixture A to 60 ℃, adding p-hydroxyacetophenone, and stirring to obtain a mixture B;
(3) Cooling the mixture B to 45 ℃, adding the rest of the soothing and repairing composition, the centella asiatica extract, the schizophyllan, the hexanediol and the colorant into the mixture B, and stirring to obtain a mixture C;
(4) Stirring the mixture C, and cooling to below 40 ℃ to obtain a semi-finished product;
(5) And feeding the semi-finished product to two sides of a mask cloth, quick-freezing, then dehumidifying, air-drying, collecting the mask, cutting, and sealing the cut product with an aluminum film to obtain the soothing and repairing freeze-dried mask.
Preferably, in the step (5), the quick-freezing condition is-196 to-40 ℃, and the dehumidifying condition is-40 to-35 ℃.
The freeze-dried mask prepared by adopting the scheme is not easy to deteriorate, has lasting efficacy, is light in weight and is convenient to carry and transport.
Compared with the prior art, the invention has the beneficial effects that:
the invention provides a soothing and repairing composition, which can effectively improve the repairing effect on skin and improve sensitive muscles by synergistic action of components in the composition. In addition, the invention also provides a freeze-dried mask containing the soothing and repairing composition, which has good moisturizing and repairing effects, and meanwhile, due to the adoption of a freeze-drying process, the mask has good stability without adding excessive preservative and has small irritation to skin.
Drawings
FIG. 1 is a graph showing the results of the moisture content test of the skin horny layer before and after using the skin-soothing and repairing freeze-dried mask of application example 1;
FIG. 2 is a graph showing the results of the test of the percutaneous moisture loss values before and after using the soothing and repairing freeze-dried mask described in application example 1;
FIG. 3 is a graph showing the results of the test of the red area a value of the skin before and after the use of the skin-soothing and repairing lyophilized mask described in application example 1.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the accompanying drawings and specific examples.
The information on some of the components in the application examples and the application comparative examples is as follows:
blue copper peptide: shandong Ji peptide biotechnology Co., ltd;
beta-glucan: guangdong Geen Biotech Co., ltd;
sodium hyaluronate: the molecular weight is (80 ten thousand to 150 ten thousand), shandong An Hua biological medicine Co., ltd;
madecassoside: guangxi Changzhou natural pharmaceutical Co., ltd;
coloring agent: gardenia jasminoides ellis extract, guangzhou city Yue Biotechnology Co., ltd;
pH regulator: arginine, commercially available.
Application examples 1 to 5
Application examples of the soothing composition according to the present invention the formulations of application examples 1 to 5 are shown in table 1.
Comparative examples 1 to 5 were used
Comparative examples 1 to 5 were used as soothing and repairing compositions, and the formulations thereof are shown in Table 1.
Table 1 (weight portions)
Application examples 1 to 5 and application comparative examples 1 to 5
Application examples 1 to 5 and application comparative examples 1 to 5 are comfort and repair freeze-dried type masks comprising, in addition to the components shown in table 1 in parts by weight, the following components in parts by weight: 1 part of butanediol, 0.75 part of sodium hyaluronate, 0.25 part of alcaligenes polysaccharide, 0.55 part of hydrolyzed sclerotium gum, 5 parts of betaine, 0.15 part of centella asiatica extract, 1 part of schizophyllan, 0.4 part of hexanediol, 0.4 part of p-hydroxyacetophenone, 0.02 part of colorant and water for supplementing to 100 parts. The preparation method of the soothing and repairing freeze-dried mask comprises the following steps of:
(1) Weighing water, butanediol, sodium hyaluronate, alcaligenes polysaccharide, hydrolyzed sclerotium gum, betaine and allantoin according to a proportion, sequentially adding into a pot, stirring while heating to 85 ℃, uniformly dispersing until no obvious particles exist, and preserving heat for 30min to obtain a mixture A;
(2) Cooling the mixture A to 60 ℃, adding p-hydroxyacetophenone, stirring and dissolving to obtain a mixture B;
(3) Cooling the mixture B to 45 ℃, adding the rest ingredients in the soothing and repairing composition, centella asiatica extract, schizophyllan, hexanediol and a colorant into the mixture B, and uniformly stirring to obtain a mixture C;
(4) Stirring the mixture C, cooling to below 40 ℃, discharging the mixture C into a sterilized container, standing, sampling and inspecting, and obtaining a semi-finished product after passing the inspection;
(5) Feeding the semi-finished product to a mask cloth subjected to irradiation sterilization, and feeding both the front side and the back side (taking a mask as an example, the single-sided feeding amount is 3.1 g); and after the feeding is finished, quick-freezing and drying the mask at the temperature of between 196 ℃ below zero and 40 ℃ below zero by liquid nitrogen equipment, dehumidifying the mask for 4min at the temperature of 35 ℃ below zero, air-drying, collecting the mask, cutting, sterilizing, folding the mask into a support, and sealing the mask by an aluminum film to obtain the soothing, repairing and freeze-drying mask.
Application examples 6 to 7
Application examples 6 to 7 are a soothing and repairing freeze-dried mask, which is prepared in the same manner as application example 5, and differs from application example 1 only in the parts by weight of the components, which contains the soothing and repairing composition of application example 1 and contains the components shown in Table 2.
Table 2 (weight portions)
| Project | Application example 6 | Application example 7 |
| Butanediol (butanediol) | 0.1 | 0.5 |
| Sodium hyaluronate | 0.6 | 0.9 |
| Alcaligenes polysaccharides | 0.3 | 0.2 |
| Hydrolyzed sclerotium rolfsii gel | 0.6 | 0.5 |
| Betaine (betaine) | 8.45 | 3 |
| Centella asiatica extract | 0.05 | 0.1 |
| Schizophyllan | 0.5 | 1.5 |
| Hexanediol (Hexadiol) | 0.2 | 0.1 |
| Para hydroxy acetophenone | 0.2 | 0.1 |
| Coloring agent | 0.02 | 0.02 |
| Water and its preparation method | Supplement to 100 | Supplement to 100 |
The mask of application examples 1 to 7 and comparative examples 1 to 5 was tested for the soothing performance, and the test sample was judged by testing the inhibition rate of the mask to hyaluronidase, and if the test sample had a certain inhibition rate to hyaluronidase, the test sample was considered to have a certain soothing effect.
The testing method comprises the following steps: and judging whether the sample has a relieving effect by utilizing the hyaluronidase inhibition rate. The higher the hyaluronidase inhibition rate of the test sample, the better the soothing effect of the test sample.
Pretreating a test sample, preparing a plurality of concentrations of sample liquid, respectively adding a hyaluronidase solution and a sodium hyaluronate solution with proper concentrations into a plurality of concentrations of sample liquid tubes, fully oscillating each tube, adding absolute ethyl alcohol, standing at room temperature for 30min, measuring a light absorption value at 530nm, and calculating the hyaluronidase inhibition rate. The results are recorded in table 3.
TABLE 3 (inhibition:%)
| Test sample | Test results | Test sample | Test results |
| Application example 1 | 82.76 | Application example 7 | 90.54 |
| Application example 2 | 80.38 | Comparative example 1 was used | 53.54 |
| Application example 3 | 85.18 | Comparative example 2 was used | 48.19 |
| Application example 4 | 87.47 | Comparative example 3 was used | 63.17 |
| Application example 5 | 91.52 | Comparative example 4 was used | 59.46 |
| Application example 6 | 88.79 | Comparative example 5 was used | 60.62 |
As shown in Table 3, the inhibition rate of the application examples 1 to 7 to the hyaluronidase is higher and can reach more than 80%, and the application comparative examples 1 to 5 can not reach 50%, which shows that the invention can jointly improve the relieving effect of the composition by selecting the combination of acetylhydroxyproline, blue copper peptide, madecassoside, allantoin and dipotassium glycyrrhizinate.
Since the facial mask of application example 3 also contains beta-glucan, the facial mask of application example 4 also contains glyceroglycosides, the soothing effect is relatively better, and the soothing effect of the facial mask of application example 5 contains both the glyceroglycosides and the beta-glucan, which is obviously better than other examples.
The repair performance of the masks of application examples 1 to 7 and comparative examples 1 to 5 was tested, and the size of the wound surface of the mice was judged by testing the masks, and if the wound area of the mice was reduced by the experimental samples, the experimental samples were considered to have a certain repair effect.
Test object: 130 female Wistar rats were selected and weighing 250g
The test method comprises the following steps: 130 rats were randomly divided into 15 groups of 10 rats each, application examples 1-7, application comparative examples 1-5, and control group, respectively. Lcm on both sides of the back spine of the rat, and a circular incision line with a radius of 1cm and an area of 3.14cm2 are marked on each of the head and tail ends of the rat in parallel with the spine. After disinfecting the skin with iodophor, the whole layer of skin is cut off along the marking line with scissors to deep fascia, forming a round wound surface. The left hand side was covered with gauze and wrapped with each of the skin care lyophilized powders prepared in application examples 1 to 7 and application comparative examples 1 to 5, and the right hand side was continuously observed for 9d without treatment.
Test results: in the continuous 9d period, the average wound area of the mice was observed relative to the size of the wound area of the first day, and the specific results are shown in Table 4
TABLE 4 average wound area size at various times
As shown in Table 4, the improvement of wound area can be more than 50% by using examples 1 to 7, but the improvement of wound area can not be 30% by using comparative examples 1 to 5, and the result shows that the soothing effect of the composition can be improved jointly by adopting acetyl hydroxyproline, blue copper peptide, madecassoside, allantoin and dipotassium glycyrrhizinate for compounding.
Since the facial mask of application example 3 also contains beta-glucan, the facial mask of application example 4 also contains glyceroglycosides, the repairing effect is relatively better, and the repairing effect of the facial mask of application example 5 contains both the glyceroglycosides and the beta-glucan, which is obviously better than other examples.
The skin irritation test using the mask of examples 1 to 7 and comparative examples 1 to 5 was evaluated by the human body patch test, the determination criteria of the skin irritation test are shown in Table 5, the specific methods are as follows, and the test results are shown in Table 6.
Application examples 1 to 7 and application comparative examples 1 to 5 were diluted to 10mg/mL with 20mmol/L PBS solution and used as a sample solution. The test was performed on a total of 60 subjects, randomly divided into 12 groups of 5 persons each. The sample solution of 0.05mL was placed in the drug chamber of the plaque test tape (PBS solution was used as a blank) with a syringe, and the plaque test tape with the sample solution placed therein was immediately applied to the normal skin of the left forearm of the subject from the lower part in a longitudinal direction while gently pressing the drug chambers one by one to expel air and uniformly distribute the sample. The test sites were marked for observation. Every 24 hours, the patch is uncovered for half an hour, and the patch is checked according to the term of CTFA guidelines, and 5 patch experiments are performed.
TABLE 5
| Grade | Degree of reaction | Skin reaction |
| 0 | － | Negative reaction: no irritation and erythema |
| 1 | ± | Suspicious reaction: mild erythema |
| 2 | + | Weak positive reaction: erythema (red spot) |
| 3 | ++ | Strong positive reaction: erythema, papule and bleb |
| 4 | +++ | Very strong positive reaction: severe edema, large foam |
TABLE 6
| Number of times of taping | 1 | 2 | 3 | 4 | 5 |
| Application example 1 | － | － | － | － | － |
| Application example 2 | － | － | － | － | － |
| Application example 3 | － | － | － | － | － |
| Application example 4 | － | － | － | － | － |
| Application example 5 | － | － | － | － | － |
| Application example 6 | － | － | － | － | － |
| Application example 7 | － | － | － | － | － |
| Comparative example 1 was used | － | － | － | － | － |
| Application ofComparative example 2 | － | － | － | － | － |
| Comparative example 3 was used | － | － | － | － | － |
| Comparative example 4 was used | － | － | － | － | － |
| Comparative example 5 was used | － | － | － | － | － |
From the above test results, the application of the masks of examples 1 to 7 and comparative examples 1 to 5 was safe and reliable, and had no irritation to the skin and no side effects on the body.
Further, the mask described in application example 1 was tested, and the test was performed with 35 subjects, 30 effective persons, 4 men, 26 women, and sensitive muscles. The results of the skin condition test were collected for the initial state (D0), 14 days (D14), and 28 days (D28) of the subject using the product, respectively.
1) Stratum corneum moisture content: skin moisture test probe model CM825 and test results are shown in table 7.
Table 7 (Unit: C.U.)
Note that: the normal test p value is more than 0.05, which shows that the data obeys normal distribution, and the paired t test is adopted, and if the data does not obey normal distribution, the rank sum test is adopted.
* P < 0.05 is shown, compared to D0, as significant differences after using samples D14, D28.
# indicates the rate of change= (DX-D0)/d0×100% (positive value indicates increase and negative value indicates decrease).
From the above test results, the moisture content of the skin horny layer of 30 subjects was significantly improved by using application examples 5D14 and D28, and the change rates were 86.09% and 119.73%, respectively, as compared with D0. The results show that the freeze-dried soothing facial mask has good moisturizing effect.
Fig. 1 is a graph showing the results of the moisture content test of the skin horny layer before and after using the soothing freeze-dried mask of application example 5, wherein p < 0.05 is represented by the graph compared with D0, and it can be seen from the graph that the moisture content of the skin horny layer of a subject is significantly improved after using samples D14 and D28 compared with D0, and the change rates are 86.09% and 119.73%, respectively.
2) Percutaneous moisture loss value: the percutaneous moisture loss test probe, model TM Hex, and the test results are shown in table 8.
Table 8 (unit: g.m) -2 ·h -1 )
Note that: the normal test p value is more than 0.05, which shows that the data obeys normal distribution, and the paired t test is adopted, and if the data does not obey normal distribution, the rank sum test is adopted.
* P < 0.05 is shown, compared to D0, as significant differences after using samples D14, D28.
# indicates the rate of change= (DX-D0)/d0×100% (positive value indicates increase and negative value indicates decrease).
As can be seen from the above test results, compared with D0, the percutaneous moisture loss values of 30 subjects were significantly reduced after using samples D14 and D28, the rates of change were-48.13% and-56.30%, respectively, and fig. 2 is a graph showing the results of the percutaneous moisture loss values before and after using the freeze-dried mask for relief according to application example 2, which shows that the freeze-dried mask for relief of the present invention has a good effect for relief.
3) Skin red area a value: the facial skin image analysis system, model VISIA, and the test results are shown in Table 9.
TABLE 9
Note that: the normal test p value is more than 0.05, which shows that the data obeys normal distribution, and the paired t test is adopted, and if the data does not obey normal distribution, the rank sum test is adopted.
* P < 0.05 is shown, compared to D0, as significant differences after using samples D14, D28.
# indicates the rate of change= (DX-D0)/d0×100% (positive value indicates increase and negative value indicates decrease).
From the above test results, it was found that the skin red area a value of 30 subjects was decreased by-5.74% and the rate of change was-7.54% by using the mask D14 of application example 5, and the skin red area a value of 30 subjects was significantly decreased by-7.54% by using the sample D28, as compared with D0. Fig. 3 is a graph showing the results of testing the red area a values of the skin before and after using the freeze-dried mask of application example 1, and the above test results show that the mask of the present invention has good repairing effect.
4) Lactic acid stinging grade was evaluated and the test results are shown in table 10.
10% lactic acid or 50. Mu.L distilled water was dropped on a filter paper having a diameter of 8mm and placed in the bilateral nasolabial folds of the subject, and the subjects were evaluated for the degree of discomfort of itching, stinging, burning pain at the test site at 30s, 2.5min and 5min, respectively. Scoring was performed by a score of 4 (no sensation at 0, mild at 1, moderate at 2, and heavy at 3). And the sum of the stinging scores of 2.5min and 5min is more than or equal to 3, and the stinging scores are positive to the lactic acid stinging. The lactic acid stinging score and the total sensory score were calculated separately.
The calculation formula of the stinging score and the total feeling score is as follows
Stinging score = 2.5min +5min lactic acid side stinging score- (2.5 min +5min distilled water side stinging score);
total sensory score = 30s+2.5min+5min lactic acid side all sensory scores- (30s+2.5min+5min distilled water side all sensory scores)
Table 10
* P < 0.05 is shown, compared to D0, as significant differences after using samples D14, D28.
# indicates the rate of change= (DX-D0)/d0×100% (positive value indicates increase and negative value indicates decrease).
As can be seen from table 10, the use of the masks D14 and D28 according to application example 2 showed significant attenuation in the lactic acid stinging score and the total sensory score, and the result showed that the mask of the present invention had a good soothing effect.
5) The consumer uses the evaluation, which is performed by a questionnaire, as follows, and the test results are shown in table 11:
skin questionnaire/product use 14 day questionnaire:
current scoring of dry, tight, skinned, itchy skin: score 0 (no sensation at all); score 1 (light feel, capable of feel, but not the most clear); score 2 (moderate sensation, clear sensation, but also tolerable); score 3 (severe sensation, intolerable);
currently scoring discomfort symptoms such as skin stinging, itching, fever, redness, etc.: score 0 (no sensation at all); score 1 (light feel, capable of feel, but not the most clear); score 2 (moderate sensation, clear sensation, but also tolerable); 3 minutes (severe feeling, intolerable).
Skin questionnaire/product use 28 day questionnaire:
current scoring of dry, tight, skinned, itchy skin: score 0 (no sensation at all); score 1 (light feel, capable of feel, but not the most clear); score 2 (moderate sensation, clear sensation, but also tolerable); score 3 (severe sensation, intolerable);
currently scoring discomfort symptoms such as skin stinging, itching, fever, redness, etc.: score 0 (no sensation at all); score 1 (light feel, capable of feel, but not the most clear); score 2 (moderate sensation, clear sensation, but also tolerable); score 3 (severe sensation, intolerable);
the product feels dry, tight and skin-peeling after use, and whether the conditions of the product are relieved: score 1 (very disagreement); score 2 (comparative disagreement); score 3 (basically disagreement); score 4 (basic acceptance); score 5 (comparative acceptance); score 6 (very acceptance);
the product can be used for relieving discomfort symptoms such as skin stinging, itching, fever, redness, etc.: score 1 (very disagreement); score 2 (comparative disagreement); score 3 (basically disagreement); score 4 (basic acceptance); score 5 (comparative acceptance); score 6 (very acceptance);
whether the product has improved skin irritation after use or not: score 1 (very disagreement); score 2 (comparative disagreement); score 3 (basically disagreement); score 4 (basic acceptance); score 5 (comparative acceptance); score 6 (very acceptance);
whether the product is suitable for sensitive muscles: score 1 (very disagreement); score 2 (comparative disagreement); score 3 (basically disagreement); score 4 (basic acceptance); score 5 (comparative acceptance); 6 minutes (very acceptance).
TABLE 11
Note that: * Indicating a significant difference after using samples D14, D28 compared to D0.
# indicates the rate of change= (DX-D0)/d0×100% (positive value indicates increase and negative value indicates decrease).
According to the test results, the facial mask disclosed by the invention has good effects of improving the dry, tight, skin-lifting and itching conditions of skin, can obviously relieve the allergic and stimulation states of the skin, and is suitable for sensitive muscles.
Finally, it should be noted that the above-mentioned embodiments are only for illustrating the technical solution of the present invention and not for limiting the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solution of the present invention without departing from the spirit and scope of the technical solution of the present invention.
Claims (10)
1. The soothing and repairing composition is characterized by comprising the following components in parts by weight: 0.05-0.15 part of acetyl hydroxyproline, 0.05-0.15 part of blue copper peptide, 0.05-0.4 part of hydroxy asiaticoside, 0.5-2 parts of allantoin, 1-2 parts of dipotassium glycyrrhizinate and 0.05-0.15 part of pH regulator.
2. The soothing repair composition of claim 1 further comprising 0.86-2.2 parts of a glucosyl glycoside.
3. The soothing repair composition of claim 2 further comprising 0.45 to 2.2 parts of beta glucan.
4. A soothing and repairing freeze-dried mask comprising the soothing and repairing composition according to any one of claims 1 to 3.
5. The soothing and repairing freeze-dried mask according to claim 4, further comprising 0.1-1 part of butanediol, 0.6-0.9 part of sodium hyaluronate, 0.2-0.3 part of alcaligenes polysaccharide, 0.5-0.6 part of hydrolyzed sclerotium rolfsii, 3-8.45 parts of betaine, 0.05-0.15 part of centella asiatica extract, 0.5-1.5 parts of schizophyllan and 0.1-0.8 part of preservative.
6. The soothing and repairing freeze-dried mask of claim 5, wherein the sodium hyaluronate has a molecular weight of 800000 ～ 1500000Da.
7. The soothing and repairing freeze-dried mask according to claim 5, wherein the preservative is at least one of hexanediol and p-hydroxyacetophenone.
8. The soothing and repairing freeze-dried facial mask of claim 5, further comprising 0.01-0.1 parts of a colorant.
9. A method of preparing a soothing and repairing freeze-dried mask according to claim 8, comprising the steps of:
(1) Weighing water, butanediol, sodium hyaluronate, alcaligenes polysaccharide, hydrolyzed sclerotium gum, betaine and allantoin according to a proportion, mixing at 80-88 ℃, stirring until no obvious particles exist, and preserving heat for 20-40 min to obtain a mixture A;
(2) Cooling the mixture A to 60 ℃, adding p-hydroxyacetophenone, and stirring to obtain a mixture B;
(3) Cooling the mixture B to 45 ℃, adding the rest of the soothing and repairing composition, the centella asiatica extract, the schizophyllan, the hexanediol and the colorant into the mixture B, and stirring to obtain a mixture C;
(4) Stirring the mixture C, and cooling to below 40 ℃ to obtain a semi-finished product;
(5) And (3) feeding the semi-finished product onto mask cloth, quick-freezing, then dehumidifying, air-drying, film collecting, cutting, and sealing the cut product with an aluminum film to obtain the soothing and repairing freeze-dried mask.
10. The preparation method according to claim 9, wherein in the step (5), the quick-freezing condition is-196 to-40 ℃, and the dehumidifying condition is-40 to-35 ℃.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117427027A (en) * | 2023-12-21 | 2024-01-23 | 舒芙雅生物科技有限公司 | Acne-removing composition and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117427027A (en) * | 2023-12-21 | 2024-01-23 | 舒芙雅生物科技有限公司 | Acne-removing composition and preparation method thereof |
| CN117427027B (en) * | 2023-12-21 | 2024-04-23 | 舒芙雅生物科技有限公司 | Acne-removing composition and preparation method thereof |
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