KR101719966B1 - 종양 줄기세포에서 eph 수용체의 발현 - Google Patents
종양 줄기세포에서 eph 수용체의 발현 Download PDFInfo
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- KR101719966B1 KR101719966B1 KR1020167002577A KR20167002577A KR101719966B1 KR 101719966 B1 KR101719966 B1 KR 101719966B1 KR 1020167002577 A KR1020167002577 A KR 1020167002577A KR 20167002577 A KR20167002577 A KR 20167002577A KR 101719966 B1 KR101719966 B1 KR 101719966B1
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| SA112330278B1 (ar) | 2011-02-18 | 2015-10-09 | ستيم سينتركس، انك. | مواد ضابطة جديدة وطرق للاستخدام |
| EP2733206A1 (en) * | 2012-11-19 | 2014-05-21 | Naroa LLC | Method for the isolation for mammalian stem cells using EphA2 and uses thereof |
| BR112016010051A2 (pt) | 2013-11-04 | 2017-12-05 | Pfizer | ?conjugados de anticorpo-fármaco anti-efna4? |
| EP3137114B8 (en) | 2014-04-30 | 2021-08-04 | Pfizer Inc. | Anti-ptk7 antibody-drug conjugates |
| KR102674191B1 (ko) | 2014-12-10 | 2024-06-11 | 하이퍼스템 에스에이 | 뇌암 줄기 세포의 성장, 이동 및 침습성 감소 그리고 뇌종양을 가진 환자의 생존 개선 방법 및 조성물 |
| US10783439B2 (en) * | 2015-05-08 | 2020-09-22 | FlowJo, LLC | Plugin interface and framework for integrating a remote server with sample data analysis software |
| EP3373939A4 (en) | 2015-11-10 | 2019-06-26 | B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University | MEDIUM AND METHOD FOR REDUCING TUMORIGENITY OF CANCER STEM CELLS |
| JP7680047B2 (ja) * | 2020-03-31 | 2025-05-20 | 慶應義塾 | ゲノム編集多能性幹細胞を用いた治療薬 |
Family Cites Families (5)
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|---|---|---|---|---|
| US20050281783A1 (en) * | 2003-10-15 | 2005-12-22 | Kinch Michael S | Listeria-based EphA2 vaccines |
| EP1778726A4 (en) * | 2004-08-16 | 2009-03-18 | Medimmune Inc | INTEGRIN ANTAGONISTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-ASSAYED CYTOTOXICITY ACTIVITY |
| US20070248628A1 (en) * | 2005-12-06 | 2007-10-25 | Keller Lorraine H | Immunogens in cancer stem cells |
| US8343461B2 (en) * | 2006-03-08 | 2013-01-01 | Wake Forest University Health Sciences | Molecular signature of cancer |
| RU2525133C2 (ru) * | 2007-08-30 | 2014-08-10 | Дайити Санкио Компани, Лимитед | Антитело к epha2 |
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Non-Patent Citations (2)
| Title |
|---|
| Mol. Cancer Res. Vol 3, pages 541-551 (2005)* |
| Oncology Reports, Vol. 19, pages 151-156 (2008)* |
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| KR20160027106A (ko) | 2016-03-09 |
| JP2020037579A (ja) | 2020-03-12 |
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| JP2018048151A (ja) | 2018-03-29 |
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| AU2011310109A1 (en) | 2013-05-02 |
| US9078857B2 (en) | 2015-07-14 |
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| CA2813101C (en) | 2018-10-30 |
| JP6523910B2 (ja) | 2019-06-05 |
| PL2621513T3 (pl) | 2017-06-30 |
| EP2621513B1 (en) | 2016-12-28 |
| EP2446895A1 (en) | 2012-05-02 |
| AU2011310109B2 (en) | 2014-11-20 |
| KR20130095286A (ko) | 2013-08-27 |
| JP2016094391A (ja) | 2016-05-26 |
| US20120083454A1 (en) | 2012-04-05 |
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