KR101709045B1 - Detachable coupling for catheter - Google Patents

Detachable coupling for catheter Download PDF

Info

Publication number
KR101709045B1
KR101709045B1 KR1020160140818A KR20160140818A KR101709045B1 KR 101709045 B1 KR101709045 B1 KR 101709045B1 KR 1020160140818 A KR1020160140818 A KR 1020160140818A KR 20160140818 A KR20160140818 A KR 20160140818A KR 101709045 B1 KR101709045 B1 KR 101709045B1
Authority
KR
South Korea
Prior art keywords
coupling
tubular body
microcatheter
tip body
tip
Prior art date
Application number
KR1020160140818A
Other languages
Korean (ko)
Other versions
KR20160130350A (en
Inventor
실바 프라빈 드
Original Assignee
코비디엔 엘피
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 코비디엔 엘피 filed Critical 코비디엔 엘피
Publication of KR20160130350A publication Critical patent/KR20160130350A/en
Application granted granted Critical
Publication of KR101709045B1 publication Critical patent/KR101709045B1/en

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/10—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/12031—Type of occlusion complete occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12195—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices comprising a curable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0009—Making of catheters or other medical or surgical tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/0069—Tip not integral with tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/76—Making non-permanent or releasable joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B29C66/1122—Single lap to lap joints, i.e. overlap joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/114—Single butt joints
    • B29C66/1142—Single butt to butt joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/52—Joining tubular articles, bars or profiled elements
    • B29C66/522—Joining tubular articles
    • B29C66/5229—Joining tubular articles involving the use of a socket
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53—Joining single elements to tubular articles, hollow articles or bars
    • B29C66/534—Joining single elements to open ends of tubular or hollow articles or to the ends of bars
    • B29C66/5344—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially annular, i.e. of finite length, e.g. joining flanges to tube ends
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B29C66/712—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined the composition of one of the parts to be joined being different from the composition of the other part
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/72—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined
    • B29C66/723—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined being multi-layered
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/94—Measuring or controlling the joining process by measuring or controlling the time
    • B29C66/949—Measuring or controlling the joining process by measuring or controlling the time characterised by specific time values or ranges
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04—Homopolymers or copolymers of ethene
    • C08L23/06—Polyethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/03—Automatic limiting or abutting means, e.g. for safety
    • A61B2090/037—Automatic limiting or abutting means, e.g. for safety with a frangible part, e.g. by reduced diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/08—Coatings comprising two or more layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M2025/0042—Microcatheters, cannula or the like having outside diameters around 1 mm or less
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
    • A61M2025/0046—Coatings for improving slidability
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/10—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using hot gases (e.g. combustion gases) or flames coming in contact with at least one of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/14—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using wave energy, i.e. electromagnetic radiation, or particle radiation
    • B29C65/16—Laser beams
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/18—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using heated tools
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
    • B29C65/4895—Solvent bonding, i.e. the surfaces of the parts to be joined being treated with solvents, swelling or softening agents, without adhesives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/52—Joining tubular articles, bars or profiled elements
    • B29C66/522—Joining tubular articles
    • B29C66/5229—Joining tubular articles involving the use of a socket
    • B29C66/52298—Joining tubular articles involving the use of a socket said socket being composed by several elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/737—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the state of the material of the parts to be joined
    • B29C66/7379—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the state of the material of the parts to be joined degradable
    • B29C66/73791—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the state of the material of the parts to be joined degradable biodegradable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/91—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux
    • B29C66/914—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux
    • B29C66/9141—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux by controlling or regulating the temperature
    • B29C66/91411—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux by controlling or regulating the temperature of the parts to be joined, e.g. the joining process taking the temperature of the parts to be joined into account
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/91—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux
    • B29C66/914—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux
    • B29C66/9141—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux by controlling or regulating the temperature
    • B29C66/91411—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux by controlling or regulating the temperature of the parts to be joined, e.g. the joining process taking the temperature of the parts to be joined into account
    • B29C66/91413—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux by controlling or regulating the temperature of the parts to be joined, e.g. the joining process taking the temperature of the parts to be joined into account the parts to be joined having different temperatures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/91—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux
    • B29C66/919—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0056—Biocompatible, e.g. biopolymers or bioelastomers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7542—Catheters
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
    • F04C2270/00—Control; Monitoring or safety arrangements
    • F04C2270/04—Force
    • F04C2270/041—Controlled or regulated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Surgical Instruments (AREA)

Abstract

본 발명은 긴 가요성 튜브형 본체, 팁 본체 및 커플링을 포함하는 마이크로카테터에 관한 것이다. 상기 긴 가요성 튜브형 본체는 기저 단부, 말단 단부, 및 긴 가요성 튜브형 본체를 통해 축방향으로 연장하는 하나 이상의 내강을 갖는다. 상기 팁 본체는 기저 단부, 말단 단부, 및 팁 본체를 통해 축방향으로 연장하는 내강을 갖는다. 상기 커플링은 튜브형 본체 및 팁 본체 둘 다의 일부를 커버하고, 제1 물질 및 제2 물질로부터 제조되며, 여기서 제1 물질은 제2 물질과 상이하다. 상기 제1 물질은 튜브형 본체의 최외각 층 및 팁 본체의 최외각 층과 상용성이고, 상기 제2 물질은 튜브형 본체 및 팁 본체 중 하나 이상과 분리가능한 결합을 형성하도록 구성된다.The present invention relates to a micro-catheter comprising a long flexible tubular body, a tip body and a coupling. The elongated flexible tubular body has a base end, a distal end, and at least one lumen extending axially through the elongate flexible tubular body. The tip body has a base end, a distal end, and a lumen extending axially through the tip body. The coupling covers a portion of both the tubular body and the tip body and is made from a first material and a second material, wherein the first material is different from the second material. The first material is compatible with the outermost layer of the tubular body and the outermost layer of the tip body, and the second material is configured to form a detachable bond with at least one of the tubular body and the tip body.

Figure R1020160140818
Figure R1020160140818

Description

분리가능한 카테터용 커플링{DETACHABLE COUPLING FOR CATHETER}≪ Desc / Clms Page number 1 > DETACHABLE COUPLING FOR CATHETER &

본 발명은 일반적으로 마이크로카테터, 및 특히 분리가능한 생체적합성 팁을 구비한 마이크로카테터에 관한 것이다.The present invention relates generally to microcatheters, and in particular to microcatheters with detachable biocompatible tips.

마이크로카테터는 일반적으로 대퇴 동맥과 같은 혈관을 통해 신체내로 삽입되고, 맥관내에서 다양한 용도를 갖는다. 마이크로카테터를 이용하여 동정맥 기형(AVM) 및 동맥류와 같은 각종 신경혈관 질환의 치료를 돕는데 사용할 수 있다.Microcatheters are generally inserted into the body through blood vessels such as the femoral artery and have a variety of uses in the veins. Can be used to assist in the treatment of various neurovascular diseases such as arteriovenous malformations (AVM) and aneurysms using microcatheters.

동맥류 및 AVM은, 뇌동맥류 및 뇌동정맥기형으로의 혈류를 영구적으로 폐색시키기 위해 마이크로카테터를 통해 전달되어 생체내에서 고화되는 조성물에 의해 맥관내에서 치료될 수 있다. 적합한 맥관내 조성물에는 단지 예로서, 생체내에서 중합되어 고체 덩어리를 형성하는 시아노아크릴레이트뿐만 아니라, 디메틸 술폭시드("DMSO")와 같은 비-수성 용매 중에 용해된 맥관구조 내로 도입시에 DMSO는 소멸되고 중합체는 수계 혈액 조성물 중에 침전되는, 생체적합성 수 불용성 중합체의 용액이 포함된다. 이러한 맥관내 조성물에는 형성된 덩어리의 가시화를 보조하기 위한 조영제가 더 포함된다.Aneurysms and AVMs can be treated in the vasculature by compositions that are delivered through a microcatheter and solidify in vivo to permanently occlude the blood flow to the cerebral aneurysm and cerebral arteriovenous malformations. Suitable intrathecal compositions include, by way of example only, cyanoacrylates that are polymerized in vivo to form solid masses, as well as DMSOs (such as DMSO) at the time of introduction into the vasculature dissolved in non-aqueous solvents such as dimethyl sulfoxide ("DMSO & Insoluble polymer that is dissolved in water and the polymer is precipitated in the water-based blood composition. Such intra-vascular compositions further include a contrast agent to assist visualization of the formed mass.

색전 조성물은 마이크로카테터로부터 색전술 부위로 전달된다. 색전 조성물은 생체내에서 고화되기 때문에 조성물의 "역류" 또는 "환류"가 일어나면 마이크로카테터의 말단 팁이 그 내부에 포획될 수 있다. 이러한 일이 발생하는 경우, 임상의는 강제로 마이크로카테터를 회수하기 위해 시도하거나(종종 마이크로카테터의 파손을 초래함), 또는 환자의 맥관내에 말단 팁을 남겨둔 채 카테터를 절단해야 한다.The embolization composition is delivered from the microcatheter to the embolization site. Because the embolization composition is solidified in vivo, the distal tip of the microcatheter can be trapped therein when "reflux" or "reflux" of the composition occurs. When this happens, the clinician must forcefully attempt to retrieve the microcatheter (often resulting in breakage of the microcatheter) or cut the catheter leaving the distal tip in the patient's vasculature.

미국 특허출원 공개공보 US2010/0049165호(Sutherland 등)는 분리 가능한 팁을 포함하는 마이크로카테터를 개시하고 있다. United States Patent Application Publication No. US2010 / 0049165 (Sutherland et al.) Discloses a microcatheter comprising a detachable tip.

따라서, 본 개시내용은, 말단 팁이 어떠한 이유로든 맥관내에 포획되는 경우 이러한 문제에 의해 초래되는 잠재적인 위험을 최소화하면서, 환자에게서 안전하게 제거될 수 있는 마이크로카테터의 제공에 관한 것이다.Accordingly, the present disclosure is directed to providing a microcatheter that can be safely removed from a patient, while minimizing the potential risk incurred by such a problem if the distal tip is trapped in the vessel for any reason.

본 개시내용은 긴 가요성 튜브형 본체, 팁 본체 및 커플링을 포함하는 마이크로카테터에 관한 것이다. 상기 긴 가요성 튜브형 본체는 기저 단부, 말단 단부, 및 긴 가요성 튜브형 본체를 통해 축방향으로 연장하는 하나 이상의 내강을 갖는다. 상기 팁 본체는 기저 단부, 말단 단부, 및 팁 본체를 통해 축방향으로 연장하는 내강을 갖는다. 상기 커플링은 튜브형 본체 및 팁 본체 둘 다의 일부를 커버하고, 제1 물질 및 제2 물질로부터 제조되며, 여기서 제1 물질은 제2 물질과 상이하다. 상기 제1 물질은 튜브형 본체의 최외각 층 및 팁 본체의 최외각 층과 상용성이다. 상기 제2 물질은 튜브형 본체 및 팁 본체 중 하나 이상과 분리가능한 결합을 형성하도록 구성된다.The present disclosure relates to a micro-catheter comprising a long flexible tubular body, a tip body and a coupling. The elongated flexible tubular body has a base end, a distal end, and at least one lumen extending axially through the elongate flexible tubular body. The tip body has a base end, a distal end, and a lumen extending axially through the tip body. The coupling covers a portion of both the tubular body and the tip body and is made from a first material and a second material, wherein the first material is different from the second material. The first material is compatible with the outermost layer of the tubular body and the outermost layer of the tip body. The second material is configured to form a releasable engagement with at least one of the tubular body and the tip body.

개시된 실시형태에서, 제1 물질은 제2 물질의 반경방향 외향에, 예를 들어 제2 물질의 전체 길이를 따라 배치된다. 본원에서는, 제1 물질이 제2 물질의 반경방향 외향에 제1 물질의 전체 길이를 따라 배치되는 것이 개시되어 있다.In the disclosed embodiment, the first material is disposed radially outward of the second material, for example along the entire length of the second material. In the present application it is disclosed that the first material is disposed along the entire length of the first material in the radially outward direction of the second material.

개시된 실시형태에서, 제2 물질은 튜브형 본체와 직접적으로 접촉한다.In the disclosed embodiment, the second material is in direct contact with the tubular body.

개시된 실시형태에서, 제1 물질은 폴리우레탄, 폴리에틸렌, 폴리테트라플루오로에틸렌(PTFE), 팽창된 폴리테트라플루오로에틸렌(EPTFE), 폴리에테르 블록 아미드, 폴리비닐 클로라이드(PVC) 및 폴리프로필렌으로 이루어지는 군으로부터 선택된다. 개시된 실시형태에서, 제2 물질은 저밀도 폴리에틸렌(LDPE), 선형 저밀도 폴리에틸렌(LLDPE) 및 고밀도 폴리에틸렌(HDPE)으로 이루어지는 군으로부터 선택된다. 본원에서, 튜브형 본체가 제1 물질로부터 제조되는 것이 개시되어 있다.In the disclosed embodiment, the first material is a material comprising polyurethane, polyethylene, polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (EPTFE), polyether block amide, polyvinyl chloride Lt; / RTI > In the disclosed embodiment, the second material is selected from the group consisting of low density polyethylene (LDPE), linear low density polyethylene (LLDPE) and high density polyethylene (HDPE). In the present application, it is disclosed that the tubular body is made from a first material.

개시된 실시형태에서, 제3 물질이 제1 물질과 제2 물질 사이에 배치된다.In the disclosed embodiment, a third material is disposed between the first material and the second material.

개시된 실시형태에서, 제1 물질은 친수성 코팅과 상용성이다.In the disclosed embodiment, the first material is compatible with the hydrophilic coating.

개시된 실시형태에서, 커플링은 단일 유닛이다.In the disclosed embodiment, the coupling is a single unit.

개시된 실시형태에서, 친수성 코팅이 포함되고, 튜브형 본체, 팁 본체 및 제1 물질과 접촉한다.In the disclosed embodiment, a hydrophilic coating is included and contacts the tubular body, the tip body, and the first material.

개시된 실시형태에서, 친수성 코팅은 튜브형 본체, 팁 본체 및 제1 물질과 접촉한다.In the disclosed embodiment, the hydrophilic coating contacts the tubular body, the tip body and the first material.

본 개시내용은 또한 튜브형 본체, 팁 본체 및 커플링을 포함하는 마이크로카테터에 관한 것이다. 상기 튜브형 본체는 기저 부분, 말단 부분, 및 유동제를 도입하기 위해 기저 부분에서 말단 부분까지 연장하는 내강을 갖는다. 상기 튜브형 본체는 제1 물질로부터 제조된다. 상기 팁 본체는 튜브형 본체의 말단 부분에 결합하고, 튜브의 내강과 연통하는 중앙 내강을 형성한다. 상기 커플링은 제1 결합을 통해 튜브형 본체의 일부와 결합하고, 제2 결합을 통해 팁 본체의 일부와 결합한다. 상기 커플링은 제1 물질 및 제2 물질을 포함하는 2가지 이상의 상이한 물질로부터 제조된다. 상기 제1 결합 및 제2 결합은 상이한 결합 강도를 갖는다.The present disclosure also relates to a microcatheter comprising a tubular body, a tip body and a coupling. The tubular body has a base portion, a distal portion, and a lumen extending from the base portion to the distal portion for introducing fluidizing agent. The tubular body is made from a first material. The tip body is coupled to a distal end portion of the tubular body and forms a central lumen communicating with the lumen of the tube. The coupling engages a portion of the tubular body through the first engagement and engages a portion of the tip body through the second engagement. The coupling is made from two or more different materials comprising a first material and a second material. The first and second bonds have different bond strengths.

개시된 실시형태에서, 제1 결합은 제2 결합보다 강하다.In the disclosed embodiment, the first coupling is stronger than the second coupling.

개시된 실시형태에서, 제1 물질은 폴리우레탄, 폴리에틸렌, 폴리테트라플루오로에틸렌(PTFE), 팽창된 폴리테트라플루오로에틸렌(EPTFE), 폴리에테르 블록 아미드, 폴리비닐 클로라이드(PVC) 및 폴리프로필렌으로 이루어지는 군으로부터 선택된다. 개시된 실시형태에서, 제2 물질은 저밀도 폴리에틸렌(LDPE), 선형 저밀도 폴리에틸렌(LLDPE) 및 고밀도 폴리에틸렌(HDPE)으로 이루어지는 군으로부터 선택된다.In the disclosed embodiment, the first material is a material comprising polyurethane, polyethylene, polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (EPTFE), polyether block amide, polyvinyl chloride Lt; / RTI > In the disclosed embodiment, the second material is selected from the group consisting of low density polyethylene (LDPE), linear low density polyethylene (LLDPE) and high density polyethylene (HDPE).

본 개시내용은 또한 마이크로카테터의 제조 방법에 관한 것이다. 본 방법은 기저 단부, 말단 단부, 및 긴 가요성 튜브형 본체를 통해 축방향으로 연장하는 하나 이상의 내강을 갖는 긴 가요성 튜브형 본체를 제공하는 것을 포함한다. 본 방법은 또한 기저 단부, 말단 단부, 및 팁 본체를 통해 축방향으로 연장하는 내강을 갖는 팁 본체를 제공하는 것을 포함한다. 본 방법은, 제1 물질이 제2 물질과 상이하고 제1 물질이 튜브형 본체의 최외각 층 및 팁 본체의 최외각 층과 상용성인, 제1 물질 및 제2 물질로부터 제조된 커플링을 제공하는 것을 더 포함한다. 본 방법은 또한 튜브형 본체의 일부 및 커플링의 일부를 가열하여 그들 사이에 제1 결합을 형성하고, 팁 본체의 일부 및 커플링의 일부를 가열하여 그들 사이에 제2 결합을 형성하는 것을 포함한다. 제1 결합과 제2 결합은 상이한 결합 강도를 갖는다.The present disclosure also relates to a method of making a microcatheter. The method includes providing a long flexible tubular body having a base end, a distal end, and at least one lumen extending axially through the elongate flexible tubular body. The method also includes providing a tip body having a base end, a distal end, and a lumen extending axially through the tip body. The method provides a coupling made from a first material and a second material, wherein the first material is different from the second material and the first material is compatible with the outermost layer of the tubular body and the outermost layer of the tip body . The method also includes heating a portion of the tubular body and a portion of the coupling to form a first coupling therebetween, and heating a portion of the tip body and a portion of the coupling to form a second coupling therebetween . The first bond and the second bond have different bond strengths.

본 개시내용은, 말단 팁이 어떠한 이유로든 맥관내에 포획되는 경우 이러한 문제에 의해 초래되는 잠재적인 위험을 최소화하면서, 환자에게서 안전하게 제거될 수 있는 마이크로카테터를 제공합니다. The present disclosure provides a microcatheter that can be safely removed from a patient while minimizing the potential hazards caused by such problems if the terminal tip is trapped in the vessel for any reason.

본 개시내용의 실시형태는 하기 도면을 참조로 하여 쉽게 이해될 것이다:
도 1은 본 개시내용에 따른 카테터의 측면 평면도이고;
도 2는 튜브형 본체, 팁 본체 및 커플링을 예시하는 도 1의 카테터 일부의 투시도이고;
도 3 및 4는 본 개시내용의 원리에 따라 환자 맥관의 구불구불한 영역 내에서의 사용되는 도 1 및 2의 카테터를 예시하고;
도 5는 본 개시내용에 따른 커플링의 제1 실시형태의 종방향 단면도이고;
도 5a는 선 5A-5A에 따른 도 5의 커플링의 횡방향 단면도이고;
도 5b는 선 5B-5B에 따른 도 5의 커플링의 횡방향 단면도이고;
도 6은 본 개시내용에 따른 커플링의 제2 실시형태의 종방향 단면도이고;
도 6a는 선 6A-6A에 따른 도 6의 커플링의 횡방향 단면도이고;
도 6b는 선 6B-6B에 따른 도 6의 커플링의 횡방향 단면도이고;
도 7은 본 개시내용에 따른 커플링의 제3 실시형태의 종방향 단면도이고;
도 7a는 선 7A-7A에 따른 도 7의 커플링의 횡방향 단면도이고;
도 7b는 선 7B-7B에 따른 도 7의 커플링의 횡방향 단면도이다.BRIEF DESCRIPTION OF THE DRAWINGS Embodiments of the present disclosure will be readily understood with reference to the following drawings:
1 is a side plan view of a catheter according to the present disclosure;
Figure 2 is a perspective view of the catheter portion of Figure 1 illustrating a tubular body, a tip body, and a coupling;
Figures 3 and 4 illustrate the catheters of Figures 1 and 2 used in the serpentine area of the patient's vasculature in accordance with the principles of the present disclosure;
5 is a longitudinal cross-sectional view of a first embodiment of a coupling according to the present disclosure;
5A is a cross-sectional side view of the coupling of FIG. 5 taken along line 5A-5A;
Figure 5b is a cross-sectional side view of the coupling of Figure 5 according to line 5B-5B;
Figure 6 is a longitudinal sectional view of a second embodiment of the coupling according to the present disclosure;
6A is a cross-sectional side view of the coupling of FIG. 6 taken along line 6A-6A;
Figure 6b is a cross-sectional side view of the coupling of Figure 6 according to line 6B-6B;
7 is a longitudinal cross-sectional view of a third embodiment of the coupling according to the present disclosure;
FIG. 7A is a cross-sectional side view of the coupling of FIG. 7 taken along line 7A-7A; FIG.
7B is a cross-sectional side view of the coupling of FIG. 7 taken along line 7B-7B.

하기 기재에서, 본원에서 사용된 용어 "기저" 및 "말단"은 내강에서의 마이크로카테터의 상대적인 위치를 지칭한다. 마이크로카테터의 "기저" 또는 "후단(trailing)" 단부는 임상의에게서 가장 근접하여 신체 외부에서 연장되는 마이크로카테터 세그먼트이다. 마이크로카테터의 "말단" 또는 "선단(leading)" 단부는 진입 부위로부터 가장 멀리 신체 내강에 위치하는 마이크로카테터 세그먼트이다.In the following description, the terms "base" and "distal ", as used herein, refer to the relative position of the microcatheter in the lumen. The "underlying" or "trailing" end of the microcatheter is a microcatheter segment that extends out of the body closest to the clinician. The "distal" or "leading" end of the microcatheter is a microcatheter segment located in the body lumen farthest from the entry site.

도 1을 참조하면, 마이크로카테터(10)는 환자의 맥관 부위로 색전 제제를 전달하는데에 유용할 수 있다. 마이크로카테터는 신체의 임의의 혈관에 사용될 수 있으나, 특히 신경혈관(neurovasculature)에서의 동맥류 또는 AVM의 색전에 유용하다. 마이크로카테터(10)는, 종방향 축 "a"를 형성하고 말단 또는 선단 단부(12) 및 기저 또는 후단 단부(14)를 갖는 튜브형 본체 세그먼트(16)를 포함한다. 마이크로카테터(10)는 튜브형 본체(16)와 동축이고 커플링(100)을 통해 튜브형 본체(16)와 분리가능하게 연결 또는 결합되는 팁 본체(30)를 더 포함한다. 용어 "분리가능하게 결합되는" 또는 "분리가능하게 연결되는"은 마이크로카테터(10)의 의도하는 용도에 따라, 설정값일 수 있는 후퇴력(retraction force)의 적용시에 팁 본체(30)가 튜브형 본체(16)로부터 결합 해제될 수 있다는 해석을 포함하고자 하는 것이다. 예를 들어, 설정된 힘은 종방향 축 "a"를 따라 튜브형 본체(16), 팁 본체(30) 또는 커플링(100) 중 적어도 하나에 적용되는 인장력일 수 있다. 다른 실시형태에서, 설정된 힘은 부품에 적용되는 전단력 또는 반경방향 힘일 수 있다. 용어 "후퇴력"은 일반적으로 마이크로카테터(10)의 종방향 축을 따라, 예를 들어 중앙 내강(22)과 평행하게 기저 방향으로, 즉 환자에게서 마이크로카테터를 회수하는 방향으로 적용되는 인장력이다. 팁 본체(30)로부터 튜브형 본체(16)를 분리하기 위해 이용되는 후퇴력은, 예를 들어 약 160 그램-힘 이하일 수 있고, 보다 특히 약 10 그램-힘 내지 약 160 그램-힘의 범위일 수 있다. 특정 실시형태에서, 후퇴력은 약 20 그램-힘 내지 약 40 그램-힘이다. 다른 실시형태에서, 후퇴력은 약 30 그램-힘 내지 약 50 그램-힘이다. 또한, 상기 기재된 범위 이외의 범위도 이용될 수 있다. 커플링(100)의 각종 실시형태가 본원 하기에 더 상세히 논의될 것이다.Referring to Figure 1, the microcatheter 10 may be useful for delivering an embolic agent to a vascular site of a patient. The microcatheter may be used in any vessel of the body, but is particularly useful for embolization of an aneurysm or AVM in a neurovasculature. The microcatheter 10 includes a tubular body segment 16 that defines a longitudinal axis "a" and has a distal or proximal end 12 and a proximal or distal end 14. The microcatheter 10 further includes a tip body 30 that is coaxial with the tubular body 16 and is removably connected or coupled to the tubular body 16 via the coupling 100. The term "detachably coupled" or "detachably connected" means that, depending on the intended use of the microcatheter 10, the tip body 30, when applied with a retraction force, And can be disengaged from the body 16. For example, the set force may be a tensile force applied to at least one of the tubular body 16, the tip body 30, or the coupling 100 along the longitudinal axis "a ". In another embodiment, the set force may be a shear force or a radial force applied to the part. The term "retraction force" is generally a tensile force applied along the longitudinal axis of the microcatheter 10, e.g., parallel to the central lumen 22, basically, i.e. in the direction of retrieving the microcatheter from the patient. The retraction force used to detach the tubular body 16 from the tip body 30 can be, for example, less than about 160 grams-force, and more particularly from about 10 grams-force to about 160 grams-force have. In certain embodiments, the retraction force is from about 20 grams force to about 40 grams force. In another embodiment, the retraction force is from about 30 grams force to about 50 grams force. Also, ranges other than those described above may be used. Various embodiments of the coupling 100 will now be discussed in greater detail.

도 1 및 2를 참조하면, 튜브형 본체(16) 및 팁 본체(30)는 외부 및 내부 직경이 동일하거나 상이할 수 있다. 마이크로카테터(10)의 기저 단부(14)는 매니폴드(18)를 포함할 수 있다. 매니폴드(18)는 긴 중앙 내강(22)에 의해 말단 접근 포트(24)와 유체 연통하는 하나 이상의 접근 포트(20)를 포함할 수 있다. 중앙 내강(22)에 의해 마이크로카테터(10)는 유도와이어(도시되지 않음)를 따르게 된다. 유도와이어의 제거 후, 중앙 내강(22)을 사용하여 색전 제제를 원하는 맥관 부위로 전달할 수 있다. 구체적으로 예시되지는 않았으나, 마이크로카테터(10)는 복수의 내강을 함유할 수 있다. 예를 들어, 하나의 내강은 유도와이어에 의해서 사용될 수 있는 한편, 또다른 내강은 색전 제제의 전달에 사용될 수 있다. 마이크로카테터(10)는 튜브형 본체(16)의 말단 단부(12)에 인접하여 위치한 마커(32), 예를 들어 방사선불투과성 마커를 포함할 수 있다. 마커(32)는 금속 또는 금속 합금, 예를 들어 백금, 백금/이리듐, 금, 니티놀 등으로부터 제조된 고리 또는 밴드일 수 있다. 개시된 실시형태에서, 커플링(100)은 방사성불투과성 물질, 예를 들어 황산바륨으로 충전될 수 있다.Referring to Figures 1 and 2, the tubular body 16 and the tip body 30 may have the same outer diameter and inner diameter. The base end 14 of the microcatheter 10 may include a manifold 18. The manifold 18 may include one or more access ports 20 in fluid communication with the distal access port 24 by a long central lumen 22. The central lumen 22 causes the microcatheter 10 to follow a guide wire (not shown). After removal of the induction wire, the central lumen 22 may be used to deliver the embolization agent to the desired vascular site. Although not specifically illustrated, the microcatheter 10 may contain a plurality of lumens. For example, one lumen may be used by the induction wire while another lumen may be used for delivery of the embolization agent. The microcatheter 10 may include a marker 32 positioned adjacent the distal end 12 of the tubular body 16, e.g., a radiopaque marker. The markers 32 may be rings or bands made from metal or metal alloys such as platinum, platinum / iridium, gold, nitinol, and the like. In the disclosed embodiment, the coupling 100 may be filled with a radio-opaque material, for example, barium sulphate.

원하는 맥관 부위로의 색전 제제의 전달을 추가로 보조하기 위해, 팁 본체(30)는 임의로 복수의 측방향 개구부 또는 홀(38)을 함유할 수 있다. 개구부(38)의 형태는 둥근형, 타원형 또는 다른 형태 중에서 선택될 수 있다.The tip body 30 may optionally include a plurality of lateral openings or holes 38 to further assist delivery of the embolic agent to the desired vascular site. The shape of the opening 38 may be round, oval or any other shape.

마이크로카테터(10)의 총 길이는, 다른 범위도 가능하지만, 일반적으로 약 150 cm 내지 약 175 cm의 범위일 수 있다. 튜브형 본체(16)는, 다른 직경도 가능하지만, 약 0.5 mm 내지 약 1.5 mm 범위 이내의 외부 직경을 갖도록 선택될 수 있다. 일부 실시형태에서, 중앙 내강(22)의 직경은, 사용되는 경우, 유도와이어의 외부 직경보다 더 큰 약 0.002 인치 내지 약 0.005 인치일 수 있다. 이러한 직경은 기저 및 말단 단부에서 적절하게 수정될 수 있다. 본원에 기재된 치수 이외의 다른 치수들이 마이크로카테터(10)의 의도하는 용도에 특히 적합하도록 본원의 개시내용의 측면에서 당업자에 의해 용이하게 이용될 수 있다.The total length of the microcatheter 10 may range from about 150 cm to about 175 cm, although other ranges are possible, generally. The tubular body 16 may be selected to have an outer diameter within the range of about 0.5 mm to about 1.5 mm, although other diameters are possible. In some embodiments, the diameter of the central lumen 22, when used, may be between about 0.002 inches and about 0.005 inches, which is greater than the outer diameter of the guide wire. Such a diameter can be suitably modified at the base and distal ends. Other dimensions than those described herein may be readily utilized by those skilled in the art in light of the teachings of the present disclosure, particularly suitable for the intended use of the microcatheter 10.

튜브형 본체(16)는 각종 물질로 또한 각종 방식으로 구성될 수 있다. 튜브형 본체(16)가 폴리우레탄, 폴리에틸렌, 폴리테트라플루오로에틸렌(PTFE), 팽창된 폴리테트라플루오로에틸렌(EPTFE), 폴리에테르 블록 아미드(상표가 피벡스. RTM(Pebax.RTM)인 것들이 포함됨), 폴리비닐 클로라이드(PVC) 및 폴리프로필렌으로 이루어지는 군으로부터 선택된 물질로부터 제조된다는 것이 구상된다. 개시된 실시형태에서, 튜브형 본체(16)는 디메틸술폭시드와 상용성인 물질로 구성될 수 있다. 또한, 튜브형 본체(16)는 이용되는 구성 방법 및 물질에 의해서도 조절될 수 있는 다양한 가요성을 가진 영역을 함유할 수도 있다. 또한, 튜브형 본체(16)는 각종 중합체, 예를 들어 폴리이미드, 폴리테트라플루오로에틸렌, 폴리에테르 블록 아미드, 폴리아미드 등의 적층에 의해서도 구성될 수 있다. 튜브형 본체(16)는 또한 각종 피치(pitch)의 브레이드(braid)를 포함할 수도 있다. 팁 본체(30)는 생체적합성 물질로부터 제조된다. "생체적합성"이란 적용된 양의 물질이 환자의 맥관에서 사용되는 경우 실질적으로 비-독성이며 실질적으로 비-면역원성임을 의미한다. 예를 들어, 팁 본체(30)가 폴리우레탄, 폴리에틸렌, 폴리테트라플루오로에틸렌(PTFE), 팽창된 폴리테트라플루오로에틸렌(EPTFE), 폴리에테르 블록 아미드, 폴리비닐 클로라이드(PVC) 및 폴리프로필렌으로 이루어지는 군으로부터 선택된 물질로부터 제조되는 것이 구상된다. 또한, 팁 본체(30)가 튜브형 본체(16)와 동일한 물질로부터 제조되는 것도 구상된다.The tubular body 16 can also be constructed of various materials and in various ways. Wherein the tubular body 16 comprises polyurethane, polyethylene, polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (EPTFE), polyether block amide (trademarks Pivex.RTM) ), Polyvinyl chloride (PVC), and polypropylene. In the disclosed embodiment, the tubular body 16 may be comprised of a material compatible with dimethyl sulfoxide. In addition, the tubular body 16 may contain regions of varying flexibility that may be controlled by the construction methods and materials utilized. The tubular body 16 may also be constructed by lamination of various polymers, such as polyimide, polytetrafluoroethylene, polyether block amide, polyamide, and the like. The tubular body 16 may also include braids of various pitches. The tip body 30 is made from a biocompatible material. "Biocompatibility" means that the applied amount of material is substantially non-toxic and substantially non-immunogenic when used in the patient's vasculature. For example, if the tip body 30 is made of polyurethane, polyethylene, polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (EPTFE), polyether block amide, polyvinyl chloride Is made from a material selected from the group consisting of. It is also envisioned that the tip body 30 is made from the same material as the tubular body 16.

특정 실시형태에서, 팁 본체(30)는 또한 "생체분해성"일 수도 있다. 마이크로카테터 팁의 구성에 유용한 광범위한 생체분해성/생체침식성(bioerodable) 및 비-생체분해성 물질이 알려져 있다. 팁 본체(30)는 동일계(in situ)에서 생체분해성 또는 생체흡수성인 물질로 형성될 수 있다. 생체분해성 또는 생체흡수성 물질, 또는 이들의 일부 조합을 사용하여 설정된 조건에서 생체분해/생체흡수되도록 한다.In certain embodiments, the tip body 30 may also be "biodegradable ". A wide variety of biodegradable / bioerodable and non-biodegradable materials useful in the construction of microcatheter tips are known. The tip body 30 may be formed in situ from a biodegradable or bioabsorbable material. Biodegradable or bioabsorbable material, or some combination thereof, to allow for biodegradation / bioabsorption under established conditions.

각종 생체적합성-생체분해성 물질이 시판되어 있고, 이러한 실시형태들에 사용하기에 적합하다. 이러한 물질의 예에는 DLPLA--폴리(dl-락티드), LPLA--폴리(l-락티드), PGA--폴리글리콜리드 , PDO--폴리(디옥사논), PGA-TMC--폴리(글리콜리드-co-트리메틸렌 카르보네이트), PGA-LPLA--폴리(l-락티드-co-글리콜리드), PGA-DLPLA--폴리(dl-락티드-co-글리콜리드), LPLA-DLPLA--폴리(l-락티드-co-dl-락티드), 및 PDO-PGA-TMC--폴리(글리콜리드-co-트리메틸렌 카르보네이트-co-디옥사논)이 포함된다.Various biocompatible-biodegradable materials are commercially available and are suitable for use in these embodiments. Examples of such materials include, but are not limited to, DLPLA poly (dl-lactide), LPLA poly (l-lactide), PGA polyglycolide, PDO poly (Glycolide-co-trimethylenecarbonate), PGA-LPLA-poly (l-lactide-co-glycolide), PGA-DLPLA-poly (dl- -DLPLA-poly (l-lactide-co-dl-lactide), and PDO-PGA-TMC-poly (glycolide-co-trimethylene carbonate-co-dioxanone).

또한, 윤활 코팅이 튜브형 본체(16), 커플링(100) 및 팁 본체(30)를 포함하는 마이크로카테터(10)의 부품 상에 배치될 수 있다는 것이 구상된다. 적합한 윤활 코팅에는 폴리비닐피롤리돈(PVP), 폴리에틸렌 옥시드, 폴리에틸렌 글리콜, 셀룰로오스성 중합체 및 친수성 말레산 무수물과 같은 친수성 물질, 또는 실리콘, PTFE, 또는 FEP와 같은 소수성 물질이 포함된다. 이러한 코팅은 일반적으로 침지 코팅 또는 분무 방법에 의해 적용되고, 가열 또는 자외선(UV) 경화도 이용될 수 있다. 예를 들어, 약 섭씨 70도 이하의 경화 온도가 실리콘 코팅에 이용되고, 섭씨 수백도가 PTFE 코팅에 요구될 수 있다. 윤활 코팅뿐만 아니라, 생체활성 코팅을 마이크로카테터의 전체 또는 일부에 적용할 수도 있다. 이러한 코팅은 또한 헤파린, 히루딘 및 그의 유사체, 또는 다른 약물과 같은 물질을 포함할 수도 있다. 이러한 코팅은 일반적으로 침지 코팅에 의해 적용된다. 생체활성 코팅은 혈액 응고의 방지를 위해 또는 특정 부위로의 약물의 전달을 위해 바람직하다.It is also contemplated that a lubricating coating may be disposed on the part of the microcatheter 10 including the tubular body 16, the coupling 100 and the tip body 30. [ Suitable lubricating coatings include hydrophilic materials such as polyvinylpyrrolidone (PVP), polyethylene oxide, polyethylene glycol, cellulosic polymers and hydrophilic maleic anhydrides, or hydrophobic materials such as silicone, PTFE, or FEP. Such coatings are generally applied by an immersion coating or spray method, and heating or ultraviolet (UV) curing may also be used. For example, a curing temperature of about 70 degrees Celsius or less is used for silicone coatings, and several hundred degrees Celsius may be required for the PTFE coating. In addition to the lubricating coating, the bioactive coating may be applied to all or part of the microcatheter. Such coatings may also include materials such as heparin, hirudin and its analogs, or other drugs. Such coatings are generally applied by dip coating. Bioactive coatings are preferred for the prevention of blood clotting or for delivery of the drug to a particular site.

커플링(100)의 각종 실시형태가 첨부 도면에 도시되어 있다. 도 5 내지 도 5b를 참조하면, 커플링(100a)의 제1 실시형태가 도시되어 있다. 커플링(100a)은 제1 물질(110a) 및 제2 물질(120a)로부터 제조된다. 또한, 임의의 제3 물질(130a)이 제1 물질(110a)과 제2 물질(120a) 사이에 도시되어 있고, 제3 물질을 사용하여 그들 사이의 결합을 형성할 수 있다. 도 5 내지 도 5b를 예시한 실시형태에서, 제1 물질(110a) 및 제2 물질(120a)은 커플링(100a)의 전체 길이 "L"만큼 연장되어 있다. 또한, 제1 물질(110a)은 커플링(100a)의 전체 길이 "L"을 따라 제2 물질(120a)의 반경방향 외향에 배치된다.Various embodiments of the coupling 100 are shown in the accompanying drawings. Referring to Figures 5 to 5B, a first embodiment of a coupling 100a is shown. Coupling 100a is fabricated from a first material 110a and a second material 120a. Also, any third material 130a is shown between the first material 110a and the second material 120a, and a third material can be used to form a bond therebetween. In the embodiment illustrated in Figures 5 to 5B, the first material 110a and the second material 120a extend by the entire length "L" of the coupling 100a. Also, the first material 110a is disposed radially outwardly of the second material 120a along the entire length "L" of the coupling 100a.

커플링(100a)의 제1 물질(110a)은 상기 기재된 바와 같이 튜브형 본체(16)의 최외각 층 및 팁 본체(30)의 최외각 층, 예컨대 친수성 코팅과 상용성인 물질을 포함하는 것으로 구상된다. 이해될 수 있는 바와 같이, 친수성 코팅과 상용성인 물질은, 침지, 스폰지 코팅, 분무 또는 당업계에 공지되어 있는 임의의 다른 통상적인 코팅 기술에 의해 친수성 코팅이 부착될 수 있는 물질을 포함한다. 예를 들어, 제1 물질(110a)에는 폴리우레탄, 폴리에틸렌, 폴리테트라플루오로에틸렌(PTFE), 팽창된 폴리테트라플루오로에틸렌(EPTFE), 폴리에테르 블록 아미드, 폴리비닐 클로라이드(PVC) 또는 폴리프로필렌이 포함되는 것으로 구상된다. 또한, 제1 물질(110a)은 튜브형 본체(16)가 제조된 물질과 동일한 것으로 구상된다.The first material 110a of the coupling 100a is conceived to include an outermost layer of the tubular body 16 and an outermost layer of the tip body 30, as described above, such as a material compatible with the hydrophilic coating . As can be appreciated, materials compatible with hydrophilic coatings include materials that can be adhered to the hydrophilic coating by dipping, sponge coating, spraying, or any other conventional coating technique known in the art. For example, the first material 110a may include polyurethane, polyethylene, polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (EPTFE), polyether block amide, polyvinyl chloride (PVC) . Also, the first material 110a is conceived to be the same as the material from which the tubular body 16 is made.

커플링(100a)의 제2 물질(120a)에 관해서는, 제2 물질(120a)이 튜브형 본체(16)와의 결합 및 팁 본체(30)와의 분리가능한 결합을 형성할 수 있는 물질을 포함하는 것으로 구상된다. 따라서, 커플링(100a)의 제2 물질(120a)에는, 예를 들어 저밀도 폴리에틸렌(LDPE), 선형 저밀도 폴리에틸렌(LLDPE) 또는 고밀도 폴리에틸렌(HDPE)이 포함되는 것으로 구상된다. 튜브형 본체(16)가 팁 본체(30)와 동일한 물질로부터 제조되는 실시형태에서는, 예를 들어 상이한 온도에서 결합을 가열함으로써 상이한 결합 강도를 갖는 결합의 형성이 달성되는 것으로 구상된다. 예를 들어, 튜브형 본체(16)와 커플링(100a) 간의 상대적으로 강한 결합을 제공하기 위해, 예를 들어 약 350℉ 내지 약 354℉의 온도에서, 예를 들어 약 7초 동안 영역을 가열함으로써 상기 결합을 생성할 수 있고; 팁 본체(30)와 커플링(100a) 간의 상대적으로 약한 결합을 제공하기 위해, 예를 들어 약 246℉ 내지 약 250℉의 온도에서, 예를 들어 약 6초 동안 영역을 가열함으로써 상기 결합을 생성할 수 있다.With regard to the second material 120a of the coupling 100a, it is contemplated that the second material 120a includes a material capable of forming a detachable coupling with the tubular body 16 and the tip body 30 It is conceived. Thus, the second material 120a of the coupling 100a is envisioned to include, for example, low density polyethylene (LDPE), linear low density polyethylene (LLDPE), or high density polyethylene (HDPE). In embodiments in which the tubular body 16 is made from the same material as the tip body 30, it is envisioned that the formation of bonds with different bond strengths is achieved, for example, by heating the bonds at different temperatures. For example, to provide a relatively strong bond between the tubular body 16 and the coupling 100a, for example, by heating the zone at a temperature of from about 350 [deg.] F to about 354 [deg.] F, To generate said bond; To provide a relatively weak bond between the tip body 30 and the coupling 100a, the bond is formed, for example, by heating the region at a temperature of from about 246 ℉ to about 250,, for example, about 6 seconds can do.

따라서, 개시된 실시형태에서, 커플링(100a)은 커플링(100a)과 팁 본체(30)를 연결하는 결합 강도에 비해 상대적으로 강한 결합을 통해 튜브형 본체(16)에 부착된다. 이러한 실시형태에서, 임상의에 의해 적용되는 적합한 후퇴력은, 커플링(100a)을 팁 본체(30)로부터 분리시키면서, 커플링(100a)은 튜브형 본체(16)에 연결되어 남아있게 한다. 이해될 수 있는 바와 같이, 강한 결합 및 약한 결합은 원하는 결과에 따라 전환시킬 수 있다. 개시된 실시형태에서, 제1 물질(110a)은 폴리에테르 블록 아미드이고, 제2 물질(120a)은 저밀도 폴리에틸렌이고, 튜브형 본체(16)의 적어도 일부는 폴리에테르 블록 아미드이다.Thus, in the disclosed embodiment, the coupling 100a is attached to the tubular body 16 through a coupling that is relatively strong compared to the coupling strength connecting the coupling 100a and the tip body 30. In this embodiment, a suitable retraction force applied by a clinician allows the coupling 100a to remain connected to the tubular body 16 while separating the coupling 100a from the tip body 30. As can be appreciated, strong and weak bonds can be converted according to the desired result. In the disclosed embodiment, the first material 110a is a polyether block amide, the second material 120a is a low density polyethylene, and at least a portion of the tubular body 16 is a polyether block amide.

또한, 제1 물질(110a)과 제2 물질(120a) 간의 결합을 형성하기 위해 사용될 수 있는 제3 물질(130a)은 플렉사르(Plexar), TYMAX™, 또는 듀퐁(Dupont)™ Bynel®로부터 제조될 수 있다. 특히, 제1 물질(110a)이 피벡스로부터 제조되고 제2 물질(120a)이 LDPE로부터 제조되는 경우, 제3 물질(130a)은 플렉사르로부터 제조되는 것으로 구상된다.Also, the third material 130a, which may be used to form a bond between the first material 110a and the second material 120a, is manufactured from Plexar, TYMAX (TM), or Dupont (TM) Bynel . In particular, when the first material 110a is made from Pivex and the second material 120a is made from LDPE, the third material 130a is intended to be made from flexar.

도 6 내지 도 6b를 참조로 하면, 커플링(100)의 제2 실시형태가 도시되어 있고, 커플링(100b)으로서 도시되어 있다. 커플링(100b)은 제1 물질(110b) 및 제2 물질(120b)로부터 제조된다. 도시된 바와 같이, 제1 물질(110b)은 제2 물질(120b)의 전체 길이를 따라 제2 물질(120b)의 반경방향 외향에 배치된다. 또한, 제1 물질(110b)과 제2 물질(120b) 간의 구별선(140b)이 존재하여 제2 물질(120b)이 커플링(100b) 길이 "L"의 일부만큼만 연장된다. 구별선(140b)이 커플링(100b)의 종방향 중심점 근처에 도시되어 있는 한편, 구별선(140b)이 도시된 위치보다 더 기저에 또는 더 말단에 위치되어 있는 것도 구상된다. 또한, 제1 물질(110b)은 제1 물질(110a)과 동일한 물질 군으로부터 선택되고, 제2 물질(120b)은 제2 물질(120a)과 동일한 물질 군으로부터 선택된다. 또한, 명백히 예시하지는 않았지만, 제3 물질은 제1 물질(110b)과 제2 물질(120b) 사이에 배치될 수 있고, 제3 물질(130a)과 동일한 물질(들)을 포함할 수도 있다.Referring to Figures 6 to 6B, a second embodiment of the coupling 100 is shown and shown as coupling 100b. Coupling 100b is fabricated from first material 110b and second material 120b. As shown, the first material 110b is disposed radially outward of the second material 120b along the entire length of the second material 120b. Also, there is a separation line 140b between the first material 110b and the second material 120b so that the second material 120b extends only a part of the length "L" of the coupling 100b. It is also contemplated that the distinctive line 140b is shown near the longitudinal center point of the coupling 100b while the distinctive line 140b is located at the base or further end of the illustrated position. Also, the first material 110b is selected from the same material group as the first material 110a, and the second material 120b is selected from the same material group as the second material 120a. Also, although not explicitly illustrated, a third material may be disposed between the first material 110b and the second material 120b, and may include the same material (s) as the third material 130a.

도 7 내지 도 7b를 참조로 하면, 커플링(100)의 제3 실시형태가 도시되어 있고, 커플링(100c)으로서 도시되어 있다. 커플링(100c)은 제1 물질(110c) 및 제2 물질(120c)로부터 제조된다. 도시된 바와 같이, 제1 물질(110c) 전체는 제2 물질(120c) 전체에 대해 기저측에 배치되어 있다. 또한, 제1 물질(110c)과 제2 물질(120c) 간의 구별선(140c)이 존재한다. 구별선(140c)은 커플링(100c)의 종방향 중심점 근처에 또한 튜브형 본체(16)와 팁 본체(30)의 연결부에 인접하여 도시되어 있으나, 구별선(140c)이 도시된 위치보다 더 기저에 또는 더 말단에 위치되어 있는 것도 구상된다. 또한, 제1 물질(110c)이 제1 물질(110a)과 동일한 물질 군으로부터 선택되고, 제2 물질(120c)이 제2 물질(120a)과 동일한 물질 군으로부터 선택되는 것도 구상된다. 또한, 명백히 예시하지는 않았지만, 제3 물질은 제1 물질(110c)과 제2 물질(120c) 사이에 배치될 수 있고, 제3 물질(130a)과 동일한 물질 군으로부터 선택될 수 있다.Referring to Figs. 7 to 7B, a third embodiment of the coupling 100 is shown and is shown as coupling 100c. Coupling 100c is fabricated from first material 110c and second material 120c. As shown in the figure, the entire first material 110c is disposed on the base side with respect to the entire second material 120c. Also, there is a distinction line 140c between the first material 110c and the second material 120c. The distinction line 140c is shown near the longitudinal center point of the coupling 100c and also adjacent to the connection of the tubular body 16 and the tip body 30, Or at the far end of the body. It is also contemplated that the first material 110c is selected from the same material group as the first material 110a and the second material 120c is selected from the same material group as the second material 120a. Also, although not explicitly illustrated, a third material may be disposed between the first material 110c and the second material 120c, and may be selected from the same material group as the third material 130a.

도 3을 다시 참조하면, 인간 신체내에서의 마이크로카테터(10)의 용도가 예시되어 있다. 구체적으로는, 마이크로카테터(10)는 서혜부(groin)와 같은 편리한 위치에서 환자에게로 삽입된다. 마이크로카테터(10)는, 팁 본체(30)가 AVM 또는 동맥류와 같은 치료 부위(40)에 도달할 때까지 맥관을 통해 진행된다. 마이크로카테터(10)의 위치는 방사선불투과성 마커(32)를 가시화함으로써 모니터링할 수 있다. 마이크로카테터(10)가 맥관내의 그의 적합한 위치에 있게 되면, 색전 제제(42)가 치료 부위(40)로 전달될 수 있다. 색전 제제(42)는 액상 색전 제제일 수 있고, 다수의 물질로 구성될 수 있다. 적합한 색전 제제(42)에는 계내 중합될 수 있는 생체적합성 중합체 및 예비중합체를 함유하는 것들이 포함된다. 액상 색전 제제는 또한 생체적합성 용매 및 조영제를 포함할 수도 있다. 일 실시형태에서, 조영제는 수-불용성이다. 이러한 하나의 실시예로는 캐나다 어바인 소재의 타이코 헬스케어 그룹 엘피 디비에이 코비디엔(Tyco Healthcare Group LP dba Covidien)으로부터 시판되는, DMSO(디메틸 술폭시드) 중 용해된 EVOH(에틸렌 비닐 알콜) 공중합체 및 현탁 미분된 탄탈 분말로 구성되어 형광투시법 하에서 가시화하기 위한 조영을 제공하는 비-접착성 액상 색전 제제인 Onyx™가 있다. 적합한 색전 제제에 대한 추가의 설명이 본원에 모두 참조로 포함되고 본 명세서의 일부를 구성하는 미국 특허 제5,667,767호; 제5,695,480호; 제6,051,607호; 제6,342,202호; 제6,531,111호; 및 제6,562,317호에 기재되어 있다.Referring again to Fig. 3, the use of the microcatheter 10 in the human body is illustrated. Specifically, the microcatheter 10 is inserted into the patient at a convenient location, such as the groin. The microcatheter 10 is advanced through the vasculature until the tip body 30 reaches the treatment site 40, such as an AVM or an aneurysm. The position of the microcatheter 10 can be monitored by visualizing the radiopaque marker 32. Once the microcatheter 10 is in its proper position within the vein, the embolization agent 42 may be delivered to the treatment site 40. The embrocation agent 42 may be a liquid embolization agent, and may be composed of a plurality of materials. Suitable embolic agents 42 include biocompatible polymers that can be polymerized in situ and those containing prepolymers. Liquid embryos may also include biocompatible solvents and contrast agents. In one embodiment, the contrast agent is water-insoluble. One such example is an EVOH (ethylene vinyl alcohol) copolymer dissolved in DMSO (dimethyl sulfoxide), available from Tyco Healthcare Group LPba Covidien of Tyco Healthcare Group of Irvine, CA, and There is Onyx (TM), a non-adhesive liquid phase embolization agent composed of suspended finely divided tantalum powder and providing contrast for visualization under fluoroscopic vision. Additional descriptions of suitable embolic agents are described in U.S. Patent No. 5,667,767, which is incorporated herein by reference in its entirety and forms part of this disclosure; 5,695,480; 6,051,607; 6,342,202; 6,531,111; And 6,562,317.

도 3 및 도 4를 참조로 하면, 색전 제제(42)의 전달 후, 팁 본체(30)가 제제(42) 내에 포획될 수 있다. 환자에게서 이러한 마이크로카테터(10)를 제거하기 위해, 주치의는 후퇴력을 튜브형 본체(16)에 적용할 수 있다. 일반적으로, 후퇴력이 적용되는 경우, 커플링(100)은 1) 팁 본체(30)에 부착되어 남아있을 수 있거나; 2) 튜브형 본체(16)에 부착되어 남아있을 수 있거나; 또는 3) 2가지 부품으로 분해됨으로써 튜브형 본체(16) 및 팁 본체(30) 둘 다에 부분적으로 부착되어 남아있을 수 있다.3 and 4, after delivery of embryo drug 42, tip body 30 may be entrapped in formulation 42. To remove such a microcatheter 10 from the patient, the primary can apply a retraction force to the tubular body 16. Generally, when a retraction force is applied, the coupling 100 can either (1) remain attached to the tip body 30; 2) may remain attached to the tubular body 16; Or 3) may be partially attached to both the tubular body 16 and the tip body 30 by disassembly into two parts.

힘을 적용한 후의 커플링(100)의 상태는, 부품의 구성 물질에 의해 또한 팁 본체(30) 및 튜브형 본체(16)로의 커플링(100)의 결합에 사용된 방법에 의해 영향을 받을 수 있다. 커플링(100)으로의 팁 본체(30)의 결합 및 커플링(100)으로의 튜브형 본체(16)의 결합은 다양한 방식으로 달성될 수 있다. 예를 들어, 커플링(100)은 튜브형 본체(16)의 말단 단부(34)와 중첩될 수 있고/거나, 팁 본체(30)의 기저 단부(36)와 중첩될 수 있다(도 2 참조). 중첩되는 양은 팁 본체(30)를 분리하기 위해 이용되는 후퇴력을 결정하는 인자가 될 수 있다. 일부 실시형태에서, 팁 본체(30) 또는 튜브형 본체(16)로의 커플링(100)의 하나 또는 둘 다로의 부착은 맞대기 이음(butt joint)(단부 대 단부)일 수 있다. 일부 실시형태에서, 말단 단부(34) 및 기저 단부(36)는 맞대기 이음을 형성할 수 있다.The state of the coupling 100 after application of the force can be influenced by the component material of the part and also by the method used for coupling the coupling 100 to the tip body 30 and the tubular body 16 . The coupling of the tip body 30 to the coupling 100 and the coupling of the tubular body 16 to the coupling 100 can be accomplished in a variety of ways. For example, the coupling 100 may overlap the distal end 34 of the tubular body 16 and / or may overlap the base end 36 of the tip body 30 (see FIG. 2) . The overlapping amount can be a factor determining the retraction force used to detach the tip body 30. In some embodiments, attachment to one or both of the coupling 100 to the tip body 30 or the tubular body 16 may be a butt joint (end to end). In some embodiments, the distal end 34 and the basal end 36 may form a butt joint.

본 개시내용은 또한 본원에 개시된 것으로서 마이크로카테터(10) 및/또는 커플링(100)의 제조 방법에 관한 것이다. 따라서, 마이크로카테터(10)와 함께 사용하기 위한 커플링(100)이 공압출을 통해 또는 몰드(예를 들어, 몰딩 또는 오버몰딩)로부터 제조되는 것이 구상된다. 또한, 상기 논의된 바와 같이, 커플링(100)을 고온 결합을 통해 카테터(10)에 결합시키는 것이 구상된다. 특히, 약 350℉ 내지 약 354℉의 온도로 약 7초 동안 커플링(100)/튜브형 본체(16)를 가열함으로써 커플링(100)을 튜브형 본체(16)에 결합시킬 수 있고, 약 246℉ 내지 약 250℉의 온도로 약 6초 동안 커플링(100)/팁 본체(30)를 가열함으로써 커플링(100)을 팁 본체(30)에 결합시킬 수 있다. 열 공급원을 적용할 때, 커플링(100)은 기계적 결합(더 작은 튜브형 본체(16) 및 팁 본체(30) 주위에서 열 수축하는 힘) 또는 용융 결합(커플링(100), 튜브형 본체(16), 및/또는 팁 본체(30)의 물질이 함께 용융됨)에 의해 튜브형 본체(16) 및 팁 본체(30)에 부착될 수 있다.The present disclosure also relates to a method of manufacturing the microcatheter 10 and / or the coupling 100 as disclosed herein. Thus, it is contemplated that the coupling 100 for use with the microcatheter 10 may be manufactured through co-extrusion or from a mold (e.g., molding or overmolding). It is also contemplated, as discussed above, to couple the coupling 100 to the catheter 10 via a high temperature engagement. In particular, coupling 100 can be coupled to tubular body 16 by heating coupling 100 / tubular body 16 at a temperature of about 350 ℉ to about 354 약 for about 7 seconds, The coupling 100 may be coupled to the tip body 30 by heating the coupling 100 / tip body 30 for a period of time of about 6 seconds to about 250 ° F. When applying a heat source, the coupling 100 may be mechanically coupled (such as by thermally contracting around the smaller tubular body 16 and tip body 30) or by melt bonding (coupling 100, tubular body 16 ), And / or the material of the tip body 30 is fused together) to the tubular body 16 and the tip body 30.

별법의 구성 방법에서는, 접착제, 열풍, 레이저, 고온 다이, 플라즈마 처리 또는 용매 결합을 이용함으로써 커플링(100)을 팁 본체(30) 및/또는 튜브형 본체(16)에 부착시킬 수 있다.Alternatively, the coupling 100 may be attached to the tip body 30 and / or the tubular body 16 by using adhesive, hot air, laser, high temperature die, plasma treatment, or solvent bonding.

또한, 커플링(100)을 튜브형 본체(16) 및/또는 팁 본체(30)와 다양한 양으로 중첩시킬 수 있는 것이 구상된다. 중첩되는 양은, 팁 본체(30)를 튜브형 본체(16) 및/또는 커플링(100)으로부터 분리하기 위해 요구되는 후퇴력에 대한 하나의 인자일 수 있다. 예를 들어, 튜브형 본체(16) 및/또는 팁 본체(30) 상에서 커플링(100)이 더 많이 중첩될수록, 2개의 부품을 분리하기 위해 더 큰 후퇴력이 필요하게 되는 것이 구상된다. 일부 실시형태에서, 이러한 중첩은 약 0.5 mm 내지 약 5 mm일 수 있다. 일부 실시형태에서, 중첩은 약 2 mm 내지 약 4 mm일 수 있다. 다른 중첩 범위도 가능하다.It is also contemplated that the coupling 100 may be overlapped with the tubular body 16 and / or the tip body 30 in various amounts. The overlapping amount may be one factor for the retraction force required to separate the tip body 30 from the tubular body 16 and / or the coupling 100. It is envisioned that the greater the coupling 100 is superimposed on the tubular body 16 and / or the tip body 30, for example, a greater retraction force is required to separate the two parts. In some embodiments, this overlap may be from about 0.5 mm to about 5 mm. In some embodiments, the overlap may be from about 2 mm to about 4 mm. Other overlapping ranges are possible.

상기 기재 및 도면은 본 개시내용의 실시형태를 기재하기 위한 목적으로 제공되었으며, 어떤 식으로든 본 개시내용의 범주를 제한하고자 하는 것은 아니다. 예를 들어, 커플링(100a 내지 100c)의 각 실시형태는 팁 본체(30)와 접촉하는 튜브형 본체(16)를 예시하지만, 그들 사이에 공간이 존재하는 것도 구상된다. 당업자에게는 각종 개질 및 변형이 본 개시내용의 취지 또는 범주를 벗어나지 않으면서 이루어질 수 있음이 명백할 것이다. 따라서, 본 개시내용은 본 개시내용의 개질 및 변형을 포함하되, 본 개시내용의 개질 및 변형이 첨부된 특허청구범위 및 그의 등가물의 범주 내에 있도록 하고자 하는 것이다.The foregoing description and drawings are provided for the purpose of describing the embodiments of the present disclosure and are not intended to limit the scope of the present disclosure in any way. For example, each embodiment of the coupling 100a-100c illustrates a tubular body 16 in contact with the tip body 30, but it is also contemplated that a space exists between them. It will be apparent to those skilled in the art that various modifications and variations can be made without departing from the spirit or scope of the disclosure. Accordingly, the present disclosure is intended to cover modifications and variations of this disclosure, such that modifications and variations of this disclosure are within the scope of the appended claims and their equivalents.

Claims (19)

기저 단부, 말단 단부, 및 축방향으로 연장하는 하나 이상의 내강을 갖는 긴 가요성 튜브형 본체;
기저 단부, 말단 단부, 및 축방향으로 연장하는 내강을 갖는 팁 본체;
튜브형 본체 및 팁 본체 둘 다의 일부를 커버하며, 제1 물질 및 제1 물질과 상이한 제2 물질로 제조되고, 제1 물질과 제2 물질 사이에 구별선을 포함하는 커플링; 및
적어도 커플링 및 팁 본체에 적용된 친수성 코팅을 포함하고,
제1 물질은 친수성 코팅과 상용성이고,
제2 물질은 튜브형 본체 및 팁 본체 중 하나 이상과 분리가능한 결합을 형성하도록 구성되고,
커플링의 제1 물질은 튜브형 본체와 직접 접촉하고 팁 본체와는 직접 접촉하지 않는,
마이크로카테터.A long flexible tubular body having a base end, a distal end, and at least one axially extending lumen;
A tip body having a base end, a distal end, and an axially extending lumen;
A coupling that covers a portion of both the tubular body and the tip body and is made of a first material and a second material different from the first material, the coupling comprising a separation line between the first material and the second material; And
At least a coupling and a hydrophilic coating applied to the tip body,
The first material is compatible with the hydrophilic coating,
Wherein the second material is configured to form a releasable engagement with at least one of the tubular body and the tip body,
The first material of the coupling being in direct contact with the tubular body and not in direct contact with the tip body,
Microcatheter. 제1항에 있어서, 제1 물질은 제2 물질의 반경방향 외향에 배치되는, 마이크로카테터.2. The microcatheter of claim 1, wherein the first material is disposed radially outwardly of the second material. 제1항에 있어서, 제1 물질은 제2 물질의 전체 길이를 따라 제2 물질의 반경방향 외향에 배치되는, 마이크로카테터.2. The microcatheter of claim 1, wherein the first material is disposed radially outwardly of the second material along the entire length of the second material. 제1항에 있어서, 제2 물질은 튜브형 본체와 직접적으로 접촉하는, 마이크로카테터.The microcatheter of claim 1, wherein the second material is in direct contact with the tubular body. 제1항에 있어서, 제2 물질은 팁 본체와 직접 접촉하고, 튜브형 본체와는 직접 접촉하지 않는, 제2 물질은 팁 본체와만 직접 접촉하는, 마이크로카테터. 2. The microcatheter of claim 1, wherein the second material is in direct contact with the tip body and the second material is in direct contact only with the tip body, wherein the second material is not in direct contact with the tubular body. 제1항에 있어서, 제1 물질이 폴리우레탄, 폴리에틸렌, 폴리테트라플루오로에틸렌(PTFE), 팽창된 폴리테트라플루오로에틸렌(EPTFE), 폴리에테르 블록 아미드, 폴리비닐 클로라이드(PVC) 및 폴리프로필렌으로 이루어지는 군으로부터 선택되는, 마이크로카테터. The method of claim 1 wherein the first material is selected from the group consisting of polyurethane, polyethylene, polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (EPTFE), polyether block amide, polyvinyl chloride Lt; RTI ID = 0.0 > of: < / RTI > 제1항에 있어서, 제2 물질이 저밀도 폴리에틸렌(LDPE), 선형 저밀도 폴리에틸렌(LLDPE) 및 고밀도 폴리에틸렌(HDPE)으로 이루어지는 군으로부터 선택되는, 마이크로카테터.The microcatheter of claim 1, wherein the second material is selected from the group consisting of low density polyethylene (LDPE), linear low density polyethylene (LLDPE) and high density polyethylene (HDPE). 제6항에 있어서, 제2 물질이 저밀도 폴리에틸렌(LDPE), 선형 저밀도 폴리에틸렌(LLDPE) 및 고밀도 폴리에틸렌(HDPE)으로 이루어지는 군으로부터 선택되는, 마이크로카테터.7. The microcatheter of claim 6, wherein the second material is selected from the group consisting of low density polyethylene (LDPE), linear low density polyethylene (LLDPE) and high density polyethylene (HDPE). 제1항에 있어서, 튜브형 본체가 제1 물질로 제조되는, 마이크로카테터.The microcatheter of claim 1 wherein the tubular body is made of a first material. 제6항에 있어서, 튜브형 본체가 제1 물질로 제조되는, 마이크로카테터.7. The microcatheter of claim 6, wherein the tubular body is made of a first material. 제1항에 있어서, 제1 물질이 폴리에테르 블록 아미드이고, 제2 물질이 저밀도 폴리에틸렌이고, 튜브형 본체의 적어도 일부가 폴리에테르 블록 아미드로 제조되는, 마이크로카테터.The microcatheter of claim 1, wherein the first material is a polyether block amide, the second material is a low density polyethylene, and at least a portion of the tubular body is made of a polyether block amide. 제1항에 있어서, 제1 물질과 제2 물질 사이에 배치되는 제3 물질을 더 포함하는, 마이크로카테터.The microcatheter of claim 1, further comprising a third material disposed between the first material and the second material. 제1항에 있어서, 커플링이 단일 유닛인 마이크로카테터.The microcatheter of claim 1, wherein the coupling is a single unit. 제1항에 있어서, 친수성 코팅이 튜브형 본체, 팁 본체 및 제1 물질과 접촉하는, 마이크로카테터.2. The microcatheter of claim 1, wherein the hydrophilic coating is in contact with the tubular body, the tip body and the first material. 기저 부분, 말단 부분, 및 유동제를 도입하기 위해 기저 부분에서 말단 부분으로 연장하는 내강을 갖고, 제1 물질로 제조된 튜브형 본체;
튜브형 본체의 말단 부분에 결합하고, 튜브형 본체의 내강과 연통하는 중앙 내강을 형성하는 팁 본체;
제1 결합을 통해 튜브형 본체의 일부와 결합하고, 제2 결합을 통해 팁 본체의 일부와 결합하고, 제1 물질 및 제2 물질을 포함하여 2가지 이상의 상이한 물질로 제조되고, 제1 물질과 제2 물질 사이에 구별선을 포함하는 커플링 - 제1 결합 및 제2 결합은 상이한 결합 강도를 갖고, 커플링의 제1 물질은 튜브형 본체와 직접 접촉하고 팁 본체와는 직접 접촉하지 않음 -; 및
적어도 커플링 및 팁 본체에 적용되는 친수성 코팅을 포함하고,
제1 물질은 친수성 코팅과 상용성인,
마이크로카테터. A tubular body made of a first material, the tubular body having a base portion, a distal portion, and a lumen extending from the base portion to the distal portion for introducing the fluidizing agent;
A tip body coupled to a distal end portion of the tubular body and defining a central lumen communicating with the lumen of the tubular body;
Wherein the first and second materials are joined to a portion of the tubular body through a first bond and coupled to a portion of the tip body through a second bond and made of two or more different materials including a first material and a second material, Wherein the first material of the coupling is in direct contact with the tubular body and is not in direct contact with the tip body; And
At least a hydrophilic coating applied to the coupling and the tip body,
The first material is compatible with the hydrophilic coating,
Microcatheter. 제15항에 있어서, 제1 결합이 제2 결합보다 더 강한 마이크로카테터.16. The microcatheter of claim 15, wherein the first engagement is stronger than the second engagement. 제15항에 있어서, 제1 물질이 폴리우레탄, 폴리에틸렌, 폴리테트라플루오로에틸렌(PTFE), 팽창된 폴리테트라플루오로에틸렌(EPTFE), 폴리에테르 블록 아미드, 폴리비닐 클로라이드(PVC) 및 폴리프로필렌으로 이루어지는 군으로부터 선택되는, 마이크로카테터.16. The method of claim 15 wherein the first material is selected from the group consisting of polyurethane, polyethylene, polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (EPTFE), polyether block amide, polyvinyl chloride Lt; RTI ID = 0.0 > of: < / RTI > 제17항에 있어서, 제2 물질이 저밀도 폴리에틸렌(LDPE), 선형 저밀도 폴리에틸렌(LLDPE) 및 고밀도 폴리에틸렌(HDPE)으로 이루어지는 군으로부터 선택되는, 마이크로카테터.18. The microcatheter of claim 17, wherein the second material is selected from the group consisting of low density polyethylene (LDPE), linear low density polyethylene (LLDPE) and high density polyethylene (HDPE). 긴 가요성 튜브형 본체의 일부 및 커플링의 일부 사이에 제1 결합을 형성하도록 긴 가요성 튜브형 본체의 일부 및 커플링의 일부를 가열하는 단계 - 긴 가요성 튜브형 본체는 기저 단부, 말단 단부, 및 축방향으로 연장하는 하나 이상의 내강을 갖고, 커플링은 제1 물질과 제2 물질로 만들어지고, 제1 물질은 제2 물질과 다르고, 커플링은 제1 물질과 제2 물질 사이에 구별선을 포함 -;
팁 본체의 일부 및 커플링의 일부 사이에 제2 결합을 형성하도록 팁 본체의 일부 및 커플링의 일부를 가열하는 단계 - 팁 본체는 기저 단부, 말단 단부, 및 축방향으로 연장하는 내강을 갖고, 제1 결합 및 제2 결합은 상이한 강도를 갖고, 커플링의 제1 물질은 튜브형 본체와 직접 접촉하고 팁 본체와는 직접 접촉하지 않음 -; 및
커플링, 튜브형 본체 및 팁 본체에 친수성 코팅을 적용하는 단계를 포함하고,
커플링의 제1 물질은 친수성 코팅과 상용성인,
마이크로카테터의 제조 방법.Heating a portion of the elongated flexible tubular body and a portion of the coupling to form a first engagement between a portion of the elongated flexible tubular body and a portion of the coupling, the elongated flexible tubular body having a proximal end, Wherein the coupling is made of a first material and a second material, wherein the first material is different from the second material, and the coupling has a line of separation between the first material and the second material include -;
Heating a portion of the tip body and a portion of the coupling to form a second engagement between a portion of the tip body and a portion of the coupling, the tip body having a base end, a distal end, and an axially extending lumen, The first and second couplings having different intensities, the first material of the coupling being in direct contact with the tubular body and not in direct contact with the tip body; And
Applying a hydrophilic coating to the coupling, tubular body and tip body,
The first material of the coupling is compatible with the hydrophilic coating,
A method of manufacturing a microcatheter.
KR1020160140818A 2012-06-19 2016-10-27 Detachable coupling for catheter KR101709045B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/526,611 US10124087B2 (en) 2012-06-19 2012-06-19 Detachable coupling for catheter
US13/526,611 2012-06-19

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020130069432A Division KR20130142933A (en) 2012-06-19 2013-06-18 Detachable coupling for catheter

Publications (2)

Publication Number Publication Date
KR20160130350A KR20160130350A (en) 2016-11-11
KR101709045B1 true KR101709045B1 (en) 2017-02-21

Family

ID=48520788

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020130069432A KR20130142933A (en) 2012-06-19 2013-06-18 Detachable coupling for catheter
KR1020160140818A KR101709045B1 (en) 2012-06-19 2016-10-27 Detachable coupling for catheter

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020130069432A KR20130142933A (en) 2012-06-19 2013-06-18 Detachable coupling for catheter

Country Status (8)

Country Link
US (1) US10124087B2 (en)
EP (1) EP2676696B1 (en)
JP (1) JP2014000399A (en)
KR (2) KR20130142933A (en)
CN (1) CN103505793B (en)
BR (1) BR102013015313A2 (en)
CA (1) CA2815040C (en)
RU (1) RU2013122046A (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103263718B (en) 2008-08-19 2016-02-24 泰科保健集团有限合伙公司 The microguide of separable end
KR101546153B1 (en) * 2012-10-24 2015-08-26 포항공과대학교 산학협력단 Squirter using ultraviolet curable polymer for aneurysm
US9877729B2 (en) 2013-12-20 2018-01-30 Microvention, Inc. Catheter system
WO2015160871A1 (en) * 2014-04-18 2015-10-22 Covidien Lp Mixing syringe
EP3131473B1 (en) 2014-04-18 2019-07-31 Covidien LP Mixing nozzle
JP7055021B2 (en) * 2015-03-02 2022-04-15 アキュレイト メディカル セラピューティクス リミテッド Catheter with side openings to modify and deliver suspension to the patient
CN106166323A (en) * 2015-05-19 2016-11-30 雅培心血管系统有限公司 Balloon catheter
WO2016185440A1 (en) 2015-05-21 2016-11-24 Ecole Polytechnique Federale De Lausanne (Epfl) Device and method for injection, photoactivation and solidifaction of liquid embolic material in the vascular system or other organic cavities
KR20180137604A (en) 2016-02-10 2018-12-27 마이크로벤션, 인코포레이티드 Devices for vascular occlusion
US10806893B2 (en) * 2017-01-10 2020-10-20 Surefire Medical, Inc. Guiding catheter having shape-retentive distal end
CN107411806A (en) * 2017-08-29 2017-12-01 江小兰 Caput femoris necrosis intervenes blood supply system
IL274383B2 (en) 2017-11-02 2024-03-01 Accurate Medical Therapeutics Ltd Embolization catheter with integral filter
US10806462B2 (en) * 2017-12-21 2020-10-20 DePuy Synthes Products, Inc. Implantable medical device detachment system with split tube and cylindrical coupling
KR20200085619A (en) * 2019-01-07 2020-07-15 김성기 Branch adapter for sap set
CN110170076A (en) * 2019-03-18 2019-08-27 苏州恒瑞宏远医疗科技有限公司 Head end can elute microtubular
US11951026B2 (en) 2020-06-30 2024-04-09 DePuy Synthes Products, Inc. Implantable medical device detachment system with flexible braid section
CN113491556B (en) * 2021-06-25 2022-07-26 四川艾迈思生物医疗科技股份有限公司 Embolism microcatheter assembly
US11937824B2 (en) 2021-12-30 2024-03-26 DePuy Synthes Products, Inc. Implant detachment systems with a modified pull wire
US11844490B2 (en) 2021-12-30 2023-12-19 DePuy Synthes Products, Inc. Suture linkage for inhibiting premature embolic implant deployment
US11937825B2 (en) 2022-03-02 2024-03-26 DePuy Synthes Products, Inc. Hook wire for preventing premature embolic implant detachment
US11937826B2 (en) 2022-03-14 2024-03-26 DePuy Synthes Products, Inc. Proximal link wire for preventing premature implant detachment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006088079A (en) 2004-09-27 2006-04-06 Bussan Nanotech Research Institute Inc Pipe end part joining body
US20070178131A1 (en) 2006-02-02 2007-08-02 I.S.T. Corporation Medical device for insertion into human body, and method of manufacture
US20100049165A1 (en) 2008-08-19 2010-02-25 Micro Therapeutics, Inc Detachable tip microcatheter

Family Cites Families (196)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2326159A (en) 1940-11-01 1943-08-10 Mendel Alfred Finger stall, catheter, sheath, or the like
DE1875646U (en) 1959-04-21 1963-07-18 Willy Ruesch CATHETERS, IN PARTICULAR INTRATRACHEAL CATHETERS.
US3058473A (en) 1959-11-27 1962-10-16 Alfred E Whitchead Remotely directing catheters and tools
SE336642B (en) 1969-10-28 1971-07-12 Astra Meditec Ab
US3656486A (en) 1970-04-08 1972-04-18 Jack R Robertson Instrument for inserting a suprapubic catheter
US3656485A (en) 1970-04-27 1972-04-18 Jack R Robertson Method of and apparatus for viewing the interior of the bladder through a suprapubic incision
SE383034B (en) 1974-04-08 1976-02-23 L I Brendling HOSE VALVE
DE2541919A1 (en) 1975-09-19 1977-03-24 Hoffmann Klaus Intestinal probe for enteral admin. of fluids and draining secretions - has soft tube with enlarged head portion and flexible guide element
US4346712A (en) 1979-04-06 1982-08-31 Kuraray Company, Ltd. Releasable balloon catheter
SU889009A1 (en) 1980-02-04 1981-12-15 Киевский научно-исследовательский институт клинической и экспериментальной хирургии Tubular tip for guiding vessel shunt in tissues
DE3010841A1 (en) 1980-03-21 1981-10-08 Ulrich Dr.med. 6936 Haag Uthmann CATHEDER
US4395806A (en) 1980-05-08 1983-08-02 Sorenson Research Co., Inc. Method of manufacturing a detachable balloon catheter assembly
US4655762A (en) * 1980-06-09 1987-04-07 Rogers Phillip P Ambulatory dialysis system and connector
US4364392A (en) 1980-12-04 1982-12-21 Wisconsin Alumni Research Foundation Detachable balloon catheter
US4545367A (en) 1982-07-16 1985-10-08 Cordis Corporation Detachable balloon catheter and method of use
US4631188A (en) 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
JPH0678460B2 (en) 1985-05-01 1994-10-05 株式会社バイオマテリアル・ユニバース Porous transparent polyvinyl alcohol gel
US4808155A (en) 1986-02-27 1989-02-28 Mahurkar Sakharam D Simple double lumen catheter
US4698056A (en) 1986-03-21 1987-10-06 Medi-Tech, Inc. Enteric feeding device
DE8614013U1 (en) 1986-05-23 1986-07-17 Uromed Kurt Drews, 2000 Oststeinbek Ureteral stent
US4739768B2 (en) 1986-06-02 1995-10-24 Target Therapeutics Inc Catheter for guide-wire tracking
DE8619671U1 (en) 1986-07-22 1989-03-09 Sterimed Gesellschaft Fuer Medizinischen Bedarf Mbh, 6600 Saarbruecken, De
DE3632573C1 (en) 1986-09-25 1988-04-21 Sterimed Gmbh Probe with insertion aid
DE3750480T2 (en) 1986-11-29 1995-03-02 Terumo Corp BALLOONED CATHETER.
US4863442A (en) 1987-08-14 1989-09-05 C. R. Bard, Inc. Soft tip catheter
US4819637A (en) 1987-09-01 1989-04-11 Interventional Therapeutics Corporation System for artificial vessel embolization and devices for use therewith
CH673432A5 (en) 1987-09-23 1990-03-15 Fischer Ag Georg
US5041090A (en) 1988-01-12 1991-08-20 Scheglov Viktor I Occluding device
US4884579A (en) 1988-04-18 1989-12-05 Target Therapeutics Catheter guide wire
US5080655A (en) 1988-05-26 1992-01-14 Haaga John R Medical biopsy needle
US4936835A (en) 1988-05-26 1990-06-26 Haaga John R Medical needle with bioabsorbable tip
US5092848A (en) 1988-10-13 1992-03-03 Deciutiis Vincent L Intravenous catheter with built-in cutting tip and method for making the same
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
FR2641692A1 (en) 1989-01-17 1990-07-20 Nippon Zeon Co Plug for closing an opening for a medical application, and device for the closure plug making use thereof
US4932938A (en) 1989-05-05 1990-06-12 Medical Engineering Corporation Urethral indwelling catheter with incontinence control
DE3916648C1 (en) 1989-05-22 1990-09-06 Fa. Carl Freudenberg, 6940 Weinheim, De
US5084063A (en) 1989-09-27 1992-01-28 United States Surgical Corporation Surgical needle-suture attachment
JP2809765B2 (en) 1989-11-28 1998-10-15 住友ベークライト株式会社 Intestinal insertion catheter
US5092873A (en) 1990-02-28 1992-03-03 Devices For Vascular Intervention, Inc. Balloon configuration for atherectomy catheter
US5122136A (en) 1990-03-13 1992-06-16 The Regents Of The University Of California Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US6083220A (en) 1990-03-13 2000-07-04 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
DE4008391C1 (en) 1990-03-16 1991-10-17 Vygon Gmbh & Co Kg, 5100 Aachen, De
US5108407A (en) 1990-06-08 1992-04-28 Rush-Presbyterian St. Luke's Medical Center Method and apparatus for placement of an embolic coil
JPH0546422Y2 (en) 1990-08-23 1993-12-06
US5221267A (en) 1990-11-30 1993-06-22 Fresenius Usa, Inc. Breakable tubing coupling
US5207648A (en) 1990-12-14 1993-05-04 The Kendall Company Multilumen catheter
US6524274B1 (en) 1990-12-28 2003-02-25 Scimed Life Systems, Inc. Triggered release hydrogel drug delivery system
US5215530A (en) 1991-07-11 1993-06-01 City Of Hope Sleeved extension and anchoring system for percutaneous catheters
US5258042A (en) 1991-12-16 1993-11-02 Henry Ford Health System Intravascular hydrogel implant
DE69324239T2 (en) 1992-01-21 1999-11-04 Univ Minnesota SEPTUAL DAMAGE CLOSURE DEVICE
HU214068B (en) 1992-02-14 1997-12-29 Minnesota Mining & Mfg Wire connector, as well as method for making thereof
DE9203077U1 (en) 1992-03-05 1992-07-30 Fuhrmann, Gerhard, Dr.
FR2689388B1 (en) 1992-04-07 1999-07-16 Celsa Lg PERFECTIONALLY RESORBABLE BLOOD FILTER.
US5263964A (en) 1992-05-06 1993-11-23 Coil Partners Ltd. Coaxial traction detachment apparatus and method
US5360418A (en) 1992-07-15 1994-11-01 Sherwood Medical Company Connector for a thoracic catheter
US5360414A (en) 1992-10-08 1994-11-01 Yarger Richard J Tube for draining body cavities, viscera and wounds
US5690666A (en) 1992-11-18 1997-11-25 Target Therapeutics, Inc. Ultrasoft embolism coils and process for using them
US5443454A (en) 1992-12-09 1995-08-22 Terumo Kabushiki Kaisha Catheter for embolectomy
WO1994015549A1 (en) 1992-12-30 1994-07-21 Schneider (Usa) Inc. Apparatus for deploying body implantable stents
WO1994023786A1 (en) 1993-04-13 1994-10-27 Boston Scientific Corporation Prosthesis delivery system
US5405339A (en) 1993-09-03 1995-04-11 Medtronic, Inc. Medical connector and method for connecting medical tubing
DE4333070C2 (en) 1993-09-29 1995-08-31 Sterimed Gmbh Hose connector
US5395353A (en) 1993-11-02 1995-03-07 Vascular Technologies, Inc. Guiding catheter with controllable perfusion ports
US5795331A (en) 1994-01-24 1998-08-18 Micro Therapeutics, Inc. Balloon catheter for occluding aneurysms of branch vessels
US5507731A (en) 1994-05-17 1996-04-16 Cordis Corporation Rapid exchange segmented catheter
US5569221A (en) 1994-07-07 1996-10-29 Ep Technologies, Inc. Catheter component bond and method
EP1304085A3 (en) 1994-09-16 2004-01-21 Ethicon Endo-Surgery, Inc. Biodegradable tissue marking device
US5570585A (en) 1994-10-03 1996-11-05 Vaynberg; Mikhail Universal cooling system automatically configured to operate in compound or single compressor mode
US5522883A (en) 1995-02-17 1996-06-04 Meadox Medicals, Inc. Endoprosthesis stent/graft deployment system
US5571168A (en) 1995-04-05 1996-11-05 Scimed Lifesystems Inc Pull back stent delivery system
US6638291B1 (en) 1995-04-20 2003-10-28 Micrus Corporation Three dimensional, low friction vasoocclusive coil, and method of manufacture
US6171326B1 (en) 1998-08-27 2001-01-09 Micrus Corporation Three dimensional, low friction vasoocclusive coil, and method of manufacture
US5645558A (en) 1995-04-20 1997-07-08 Medical University Of South Carolina Anatomically shaped vasoocclusive device and method of making the same
US5620427A (en) 1995-04-27 1997-04-15 David R. Kipp Luer lock system
US5667767A (en) 1995-07-27 1997-09-16 Micro Therapeutics, Inc. Compositions for use in embolizing blood vessels
US5580568A (en) 1995-07-27 1996-12-03 Micro Therapeutics, Inc. Cellulose diacetate compositions for use in embolizing blood vessels
US5769882A (en) 1995-09-08 1998-06-23 Medtronic, Inc. Methods and apparatus for conformably sealing prostheses within body lumens
US5868704A (en) * 1995-09-18 1999-02-09 W. L. Gore & Associates, Inc. Balloon catheter device
US5609164A (en) 1995-10-23 1997-03-11 Minnesota Mining And Manufacturing Company Method of forming an earplug containment device
US5843050A (en) 1995-11-13 1998-12-01 Micro Therapeutics, Inc. Microcatheter
US5749894A (en) 1996-01-18 1998-05-12 Target Therapeutics, Inc. Aneurysm closure method
US5702361A (en) 1996-01-31 1997-12-30 Micro Therapeutics, Inc. Method for embolizing blood vessels
EP0879068A4 (en) 1996-02-02 1999-04-21 Transvascular Inc Methods and apparatus for blocking flow through blood vessels
DE19610333A1 (en) 1996-03-17 1997-09-18 M Dr Mausbach Apparatus and process for introduction and release of implant in vivo
US5921954A (en) 1996-07-10 1999-07-13 Mohr, Jr.; Lawrence G. Treating aneurysms by applying hardening/softening agents to hardenable/softenable substances
US5833644A (en) 1996-05-20 1998-11-10 Percusurge, Inc. Method for emboli containment
US6270477B1 (en) 1996-05-20 2001-08-07 Percusurge, Inc. Catheter for emboli containment
AU2745497A (en) 1996-05-31 1998-01-05 Micro Therapeutics, Inc. Compositions for use in embolizing blood vessels
US5913848A (en) 1996-06-06 1999-06-22 Luther Medical Products, Inc. Hard tip over-the-needle catheter and method of manufacturing the same
US5728133A (en) 1996-07-09 1998-03-17 Cardiologics, L.L.C. Anchoring device and method for sealing percutaneous punctures in vessels
US5830178A (en) 1996-10-11 1998-11-03 Micro Therapeutics, Inc. Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide
US5695480A (en) 1996-07-29 1997-12-09 Micro Therapeutics, Inc. Embolizing compositions
US5902310A (en) 1996-08-12 1999-05-11 Ethicon Endo-Surgery, Inc. Apparatus and method for marking tissue
US5776097A (en) 1996-12-19 1998-07-07 University Of California At Los Angeles Method and device for treating intracranial vascular aneurysms
US5791036A (en) 1996-12-23 1998-08-11 Schneider (Usa) Inc Catheter transition system
US6258079B1 (en) 1997-01-21 2001-07-10 Vasca, Inc. Method and systems for establishing vascular access
US5911737A (en) 1997-02-28 1999-06-15 The Regents Of The University Of California Microfabricated therapeutic actuators
US5895378A (en) 1997-05-29 1999-04-20 Target Therapeutics, Inc. Flow-directed catheter having multiple tapers and radio-opaque markers
US6139525A (en) 1997-07-08 2000-10-31 Advanced Cardiovascular Systems, Inc. Fusion bonding of catheter components
US5951599A (en) 1997-07-09 1999-09-14 Scimed Life Systems, Inc. Occlusion system for endovascular treatment of an aneurysm
US5928260A (en) 1997-07-10 1999-07-27 Scimed Life Systems, Inc. Removable occlusion system for aneurysm neck
GB9715241D0 (en) 1997-07-18 1997-09-24 Jeffree Martin A Device for treating aneurysms
US5984929A (en) 1997-08-29 1999-11-16 Target Therapeutics, Inc. Fast detaching electronically isolated implant
US5895410A (en) 1997-09-12 1999-04-20 B. Braun Medical, Inc. Introducer for an expandable vascular occlusion device
US6511468B1 (en) 1997-10-17 2003-01-28 Micro Therapeutics, Inc. Device and method for controlling injection of liquid embolic composition
US6146373A (en) 1997-10-17 2000-11-14 Micro Therapeutics, Inc. Catheter system and method for injection of a liquid embolic composition and a solidification agent
JP4130234B2 (en) 1997-10-30 2008-08-06 株式会社カネカメディックス Medical device for placement of in-vivo indwelling members
US6015541A (en) 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions
US20040260333A1 (en) 1997-11-12 2004-12-23 Dubrul William R. Medical device and method
US6159165A (en) 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US6136015A (en) 1998-08-25 2000-10-24 Micrus Corporation Vasoocclusive coil
US6168570B1 (en) 1997-12-05 2001-01-02 Micrus Corporation Micro-strand cable with enhanced radiopacity
US6241691B1 (en) 1997-12-05 2001-06-05 Micrus Corporation Coated superelastic stent
NL1008178C2 (en) 1998-02-02 1999-08-04 Cordis Europ Sealing between catheter body and balloon
WO1999039649A1 (en) 1998-02-10 1999-08-12 Dubrul William R Occlusion, anchoring, tensioning and flow direction apparatus and methods for use
US6346091B1 (en) 1998-02-13 2002-02-12 Stephen C. Jacobsen Detachable coil for aneurysm therapy
US6022369A (en) 1998-02-13 2000-02-08 Precision Vascular Systems, Inc. Wire device with detachable end
US5941888A (en) 1998-02-18 1999-08-24 Target Therapeutics, Inc. Vaso-occlusive member assembly with multiple detaching points
US6077260A (en) 1998-02-19 2000-06-20 Target Therapeutics, Inc. Assembly containing an electrolytically severable joint for endovascular embolic devices
WO1999048548A1 (en) 1998-03-23 1999-09-30 Medtronic, Inc. Catheter having extruded radiopaque stripes embedded in soft tip and method of fabrication
US5957912A (en) 1998-04-16 1999-09-28 Camino Neurocare, Inc. Catheter having distal stylet opening and connector
US6015424A (en) 1998-04-28 2000-01-18 Microvention, Inc. Apparatus and method for vascular embolization
US6171296B1 (en) 1998-04-28 2001-01-09 Microtherapeutics, Inc. Flow directed catheter
US6168615B1 (en) 1998-05-04 2001-01-02 Micrus Corporation Method and apparatus for occlusion and reinforcement of aneurysms
DE29908453U1 (en) 1998-05-12 1999-09-23 Novartis Nutrition Ag Bern Ostomy tube placement tip
US6463317B1 (en) 1998-05-19 2002-10-08 Regents Of The University Of Minnesota Device and method for the endovascular treatment of aneurysms
US6293960B1 (en) 1998-05-22 2001-09-25 Micrus Corporation Catheter with shape memory polymer distal tip for deployment of therapeutic devices
US6051607A (en) 1998-07-02 2000-04-18 Micro Therapeutics, Inc. Vascular embolizing compositions comprising ethyl lactate and methods for their use
US6165193A (en) 1998-07-06 2000-12-26 Microvention, Inc. Vascular embolization with an expansible implant
US6102917A (en) 1998-07-15 2000-08-15 The Regents Of The University Of California Shape memory polymer (SMP) gripper with a release sensing system
US6093199A (en) 1998-08-05 2000-07-25 Endovascular Technologies, Inc. Intra-luminal device for treatment of body cavities and lumens and method of use
US6179860B1 (en) 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
US6296622B1 (en) 1998-12-21 2001-10-02 Micrus Corporation Endoluminal device delivery system using axially recovering shape memory material
US6224610B1 (en) 1998-08-31 2001-05-01 Micrus Corporation Shape memory polymer intravascular delivery system with heat transfer medium
US6478773B1 (en) 1998-12-21 2002-11-12 Micrus Corporation Apparatus for deployment of micro-coil using a catheter
US7410482B2 (en) 1998-09-04 2008-08-12 Boston Scientific-Scimed, Inc. Detachable aneurysm neck bridge
US6059769A (en) 1998-10-02 2000-05-09 Medtronic, Inc. Medical catheter with grooved soft distal segment
US6277126B1 (en) 1998-10-05 2001-08-21 Cordis Neurovascular Inc. Heated vascular occlusion coil development system
AU6288799A (en) 1998-10-09 2000-05-01 Cook Incorporated Vasoocclusion coil device having a core therein
US6152144A (en) 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US6245053B1 (en) 1998-11-09 2001-06-12 Medtronic, Inc. Soft tip guiding catheter and method of fabrication
US6102932A (en) 1998-12-15 2000-08-15 Micrus Corporation Intravascular device push wire delivery system
US6835185B2 (en) 1998-12-21 2004-12-28 Micrus Corporation Intravascular device deployment mechanism incorporating mechanical detachment
FR2788216B1 (en) 1999-01-08 2001-03-30 Balt Extrusion DEVICE FOR SEALING AN ANEVRISM OR THE LIKE IN A BLOOD VESSEL LIKE AN ARTERY
US6203779B1 (en) 1999-03-19 2001-03-20 Charlie Ricci Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms
US6361528B1 (en) 1999-04-05 2002-03-26 Acist Medical Systems, Inc. Dynamically compliant catheter
ES2319725T3 (en) 1999-05-21 2009-05-12 Micro Therapeutics, Inc. HIGH VISCOSITY EMBOLIZING COMPOSITIONS.
US6663607B2 (en) 1999-07-12 2003-12-16 Scimed Life Systems, Inc. Bioactive aneurysm closure device assembly and kit
US6602261B2 (en) 1999-10-04 2003-08-05 Microvention, Inc. Filamentous embolic device with expansile elements
US6238403B1 (en) 1999-10-04 2001-05-29 Microvention, Inc. Filamentous embolic device with expansible elements
US6371971B1 (en) 1999-11-15 2002-04-16 Scimed Life Systems, Inc. Guidewire filter and methods of use
US6368301B1 (en) 1999-12-21 2002-04-09 Advanced Cardiovascular Systems, Inc. Catheter having a soft distal tip
US6322586B1 (en) 2000-01-10 2001-11-27 Scimed Life Systems, Inc. Catheter tip designs and method of manufacture
US20050043703A1 (en) 2003-08-21 2005-02-24 Greg Nordgren Slit valves for catheter tips and methods
DE20009204U1 (en) 2000-05-22 2000-08-17 Jomed Gmbh Stent implantation catheter assembly
AU7132001A (en) 2000-06-16 2002-01-02 Abbott Lab Balloon occlusion device having a proximal valve
US20030176857A1 (en) 2000-07-26 2003-09-18 Lee Kyu Ho Assembly for embolic treatments
US6723108B1 (en) 2000-09-18 2004-04-20 Cordis Neurovascular, Inc Foam matrix embolization device
SE517104C2 (en) 2000-09-25 2002-04-16 Bjoern Flodin Device for fixing a pipe means
US6689141B2 (en) 2000-10-18 2004-02-10 Microvention, Inc. Mechanism for the deployment of endovascular implants
US6607538B1 (en) 2000-10-18 2003-08-19 Microvention, Inc. Mechanism for the deployment of endovascular implants
US6743251B1 (en) 2000-11-15 2004-06-01 Scimed Life Systems, Inc. Implantable devices with polymeric detachment junction
US6494884B2 (en) 2001-02-09 2002-12-17 Concentric Medical, Inc. Methods and devices for delivering occlusion elements
US20020165582A1 (en) 2001-04-26 2002-11-07 Porter Christopher H. Method and apparatus for delivering materials to the body
JP4383746B2 (en) 2001-05-29 2009-12-16 マイクロベンション インコーポレイテッド Method for producing inflatable thread-like embolic device
CA2449137A1 (en) 2001-06-01 2002-12-05 Jean Raymond Detachable tip microcatheter for use of liquid embolic agents
US6673058B2 (en) 2001-06-20 2004-01-06 Scimed Life Systems, Inc. Temporary dilating tip for gastro-intestinal tubes
US6692461B2 (en) 2001-08-07 2004-02-17 Advanced Cardiovascular Systems, Inc. Catheter tip
US6918920B1 (en) 2001-11-01 2005-07-19 Advanced Cardiovascular Systems, Inc. Catheter having an improved distal tip
US6716223B2 (en) 2001-11-09 2004-04-06 Micrus Corporation Reloadable sheath for catheter system for deploying vasoocclusive devices
US7507230B2 (en) 2002-02-19 2009-03-24 Boston Scientific Scimed, Inc. Medical catheter assembly including multi-piece connector
DE10217509A1 (en) 2002-04-19 2003-11-06 Biotronik Mess & Therapieg Cardiovascular catheter
US7338511B2 (en) 2002-05-24 2008-03-04 Boston Scientific-Scimed, Inc. Solid embolic material with variable expansion
US6730095B2 (en) 2002-06-26 2004-05-04 Scimed Life Systems, Inc. Retrograde plunger delivery system
US6953470B2 (en) 2002-09-11 2005-10-11 Boston Scientific Scimed, Inc. Catheter support
US7229454B2 (en) 2003-01-07 2007-06-12 Boston Scientific Scimed, Inc. Occlusive cinching devices and methods of use
US20080208160A9 (en) 2003-01-10 2008-08-28 Mawad Michel E Microcatheter including swellable tip
DE10303744B4 (en) 2003-01-30 2006-06-14 Sorin Group Deutschland Gmbh aortic
US8123774B2 (en) 2003-03-20 2012-02-28 Boston Scientific Scimed, Inc. Piezoelectric vascular implant release device
DE20304533U1 (en) 2003-03-21 2004-08-05 Impella Cardiosystems Ag An insertion device for inserting an object into a body vessel
US20040236364A1 (en) 2003-05-22 2004-11-25 Jones Donald K. Method of treating aneurysms with bioabsorbable polymers
US20040254528A1 (en) 2003-06-12 2004-12-16 Adams Daniel O. Catheter with removable wire lumen segment
US7735493B2 (en) 2003-08-15 2010-06-15 Atritech, Inc. System and method for delivering a left atrial appendage containment device
US7462188B2 (en) 2003-09-26 2008-12-09 Abbott Laboratories Device and method for suturing intracardiac defects
DE20319306U1 (en) 2003-12-13 2005-05-04 B. Braun Medicare Gmbh & Co. Kg Urine drainage catheter with provision for lubrication and antisepsis includes flexible tube running along interior of catheter lumen and connected to outlet on catheter tip
US20050159773A1 (en) 2004-01-20 2005-07-21 Scimed Life Systems, Inc. Expandable retrieval device with dilator tip
US7674251B2 (en) 2004-04-08 2010-03-09 Boston Scientific Scimed, Inc. Medical devices including aerated adhesive bonds and methods of forming the same
US7331613B2 (en) 2004-05-13 2008-02-19 Medtronic, Inc. Medical tubing connector assembly incorporating strain relief sleeve
US20060106421A1 (en) 2004-11-16 2006-05-18 Clifford Teoh Expansible neck bridge
US20060116636A1 (en) 2004-11-30 2006-06-01 Murphy Kieran P Self-sealing catheter for deformable tissue
WO2007039678A1 (en) 2005-10-05 2007-04-12 Balt Extrusion Safety catheter for fluid injection
FR2896421A1 (en) 2006-01-20 2007-07-27 Balt Extrusion Sa Fluid e.g. embolic liquid, injection catheter for e.g. endovascular treatment, has connecting unit comprising ring and arranged such that end piece is separated from body by exerting couple of forces
US20080108974A1 (en) 2006-10-20 2008-05-08 Vital Signs, Inc. Reinforced catheter with radiopaque distal tip and process of manufacture
US20090044811A1 (en) 2007-08-16 2009-02-19 Kimberly-Clark Worldwide, Inc. Vent and strap fastening system for a disposable respirator providing improved donning
US8016799B2 (en) 2008-04-22 2011-09-13 Medtronic Vascular, Inc. Catheter having a detachable tip
US20120157854A1 (en) * 2010-12-15 2012-06-21 Cook Incorporated System and method for gaining percutaneous access to a body lumen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006088079A (en) 2004-09-27 2006-04-06 Bussan Nanotech Research Institute Inc Pipe end part joining body
US20070178131A1 (en) 2006-02-02 2007-08-02 I.S.T. Corporation Medical device for insertion into human body, and method of manufacture
US20100049165A1 (en) 2008-08-19 2010-02-25 Micro Therapeutics, Inc Detachable tip microcatheter

Also Published As

Publication number Publication date
CA2815040A1 (en) 2013-12-19
RU2013122046A (en) 2014-11-20
US20130338643A1 (en) 2013-12-19
CN103505793A (en) 2014-01-15
JP2014000399A (en) 2014-01-09
EP2676696B1 (en) 2016-08-03
KR20130142933A (en) 2013-12-30
CA2815040C (en) 2016-09-13
US10124087B2 (en) 2018-11-13
CN103505793B (en) 2016-08-10
EP2676696A1 (en) 2013-12-25
KR20160130350A (en) 2016-11-11
BR102013015313A2 (en) 2015-06-23

Similar Documents

Publication Publication Date Title
KR101709045B1 (en) Detachable coupling for catheter
EP2740511B1 (en) Microcatheter
TWI789782B (en) Medical system
JP6780637B2 (en) Vascular embolus tool and its manufacturing method
JP4084661B2 (en) Implantable device with polymeric detachment joint
US9775620B2 (en) Composite detachment mechanisms
CN103356258B (en) There is the Embolic coil detachment mechanism of flexible distal component and connection unit
US20100256666A1 (en) Delivery wire for occlusive device delivery system
KR101103303B1 (en) Detachable micro-coil assembly
JP7097365B2 (en) In-vivo indwelling device and in-vivo indwelling device delivery system

Legal Events

Date Code Title Description
A107 Divisional application of patent
A201 Request for examination
E701 Decision to grant or registration of patent right