KR101702159B1 - (4―페닐―피페리딘―1―일)―[5―(1h―피라졸―4―일)―티오펜―3―일]―메탄온 화합물 및 그의 용도 - Google Patents
(4―페닐―피페리딘―1―일)―[5―(1h―피라졸―4―일)―티오펜―3―일]―메탄온 화합물 및 그의 용도 Download PDFInfo
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- KR101702159B1 KR101702159B1 KR1020127006255A KR20127006255A KR101702159B1 KR 101702159 B1 KR101702159 B1 KR 101702159B1 KR 1020127006255 A KR1020127006255 A KR 1020127006255A KR 20127006255 A KR20127006255 A KR 20127006255A KR 101702159 B1 KR101702159 B1 KR 101702159B1
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- FCLMXEAPEVBCKQ-UHFFFAOYSA-N OC1(CCN(Cc2ccccc2)CC1)c1ccccc1 Chemical compound OC1(CCN(Cc2ccccc2)CC1)c1ccccc1 FCLMXEAPEVBCKQ-UHFFFAOYSA-N 0.000 description 2
- 0 CC(C(*)C(C)(C(C1I)I)C2=CC=CC(C)(*)C=C2)N1C(c1c[s]c(-c2c(*)[n](N)nc2*)c1)=O Chemical compound CC(C(*)C(C)(C(C1I)I)C2=CC=CC(C)(*)C=C2)N1C(c1c[s]c(-c2c(*)[n](N)nc2*)c1)=O 0.000 description 1
- WCRUBXNQVAOTCB-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CC=C1c1c(C#N)cccc1)=O Chemical compound CC(C)(C)OC(N(CC1)CC=C1c1c(C#N)cccc1)=O WCRUBXNQVAOTCB-UHFFFAOYSA-N 0.000 description 1
- KQKFQBTWXOGINC-UHFFFAOYSA-N OC1(CCNCC1)c1ccccc1 Chemical compound OC1(CCNCC1)c1ccccc1 KQKFQBTWXOGINC-UHFFFAOYSA-N 0.000 description 1
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- C07D451/06—Oxygen atoms
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- Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
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- Endocrinology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24282509P | 2009-09-16 | 2009-09-16 | |
| US61/242,825 | 2009-09-16 | ||
| PCT/GB2010/001732 WO2011033255A1 (en) | 2009-09-16 | 2010-09-14 | (4-phenyl-piperidin-1-yl)-[5-1h-pyrazol-4yl)-thiophen-3-yl]-methanone compounds and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20120093161A KR20120093161A (ko) | 2012-08-22 |
| KR101702159B1 true KR101702159B1 (ko) | 2017-02-02 |
Family
ID=42946621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127006255A Expired - Fee Related KR101702159B1 (ko) | 2009-09-16 | 2010-09-14 | (4―페닐―피페리딘―1―일)―[5―(1h―피라졸―4―일)―티오펜―3―일]―메탄온 화합물 및 그의 용도 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8642621B2 (enExample) |
| EP (1) | EP2477983B1 (enExample) |
| JP (1) | JP5779181B2 (enExample) |
| KR (1) | KR101702159B1 (enExample) |
| AU (1) | AU2010297068B2 (enExample) |
| CA (1) | CA2772504C (enExample) |
| DK (1) | DK2477983T3 (enExample) |
| ES (1) | ES2540547T3 (enExample) |
| IL (1) | IL218315A (enExample) |
| IN (1) | IN2012DN02590A (enExample) |
| WO (1) | WO2011033255A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0724251D0 (en) | 2007-12-12 | 2008-02-06 | Univ Edinburgh | Therapeutic compounds and their use |
| GB0804685D0 (en) | 2008-03-13 | 2008-04-16 | Univ Edinburgh | Therapeutic compounds and their use |
| US8642621B2 (en) | 2009-09-16 | 2014-02-04 | The University Of Edinburgh | (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds and their use |
| CN102947295B (zh) * | 2010-04-29 | 2016-01-20 | 爱丁堡大学 | 作为11β-HSD1抑制剂的3,3-二取代的-(8-氮杂双环[3.2.1]辛烷-8-基)-[5-(1H-吡唑-4基)-噻吩-3-基]-甲酮 |
| US9650337B2 (en) | 2013-02-14 | 2017-05-16 | Galderma Research & Development | Method of synthesising 4-piperidin-4-yl-benzene-1,3-diol and the salts of same and novel compound tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate |
| EP2968303B1 (en) | 2013-03-14 | 2018-07-04 | The Trustees of Columbia University in the City of New York | Octahydrocyclopentapyrroles, their preparation and use |
| WO2014151936A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles, their preparation and use |
| US10273243B2 (en) | 2013-03-14 | 2019-04-30 | The Trustees Of Columbia University In The City Of New York | 4-phenylpiperidines, their preparation and use |
| WO2014151959A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
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| US20060111366A1 (en) | 2003-04-11 | 2006-05-25 | Novo Nordisk A/S | Pharmaceutical use of substituted amides |
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| JP2013504613A (ja) | 2013-02-07 |
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