KR101665093B1 - Composition for teeth-alveolar bone and functional food containing the same - Google Patents
Composition for teeth-alveolar bone and functional food containing the same Download PDFInfo
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- KR101665093B1 KR101665093B1 KR1020150084431A KR20150084431A KR101665093B1 KR 101665093 B1 KR101665093 B1 KR 101665093B1 KR 1020150084431 A KR1020150084431 A KR 1020150084431A KR 20150084431 A KR20150084431 A KR 20150084431A KR 101665093 B1 KR101665093 B1 KR 101665093B1
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- extract
- composition
- alveolar bone
- present
- teeth
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- 239000011230 binding agent Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000002805 bone matrix Anatomy 0.000 description 1
- 230000024279 bone resorption Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
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- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
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- 235000013373 food additive Nutrition 0.000 description 1
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- 230000008014 freezing Effects 0.000 description 1
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- 239000008273 gelatin Substances 0.000 description 1
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- 230000008571 general function Effects 0.000 description 1
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- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229930013686 lignan Natural products 0.000 description 1
- 235000009408 lignans Nutrition 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 238000009629 microbiological culture Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229940124595 oriental medicine Drugs 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 210000002379 periodontal ligament Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
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- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 235000003784 poor nutrition Nutrition 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical class C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000007447 staining method Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000012089 stop solution Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000008513 turmeric extract Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 235000009492 vitamin B5 Nutrition 0.000 description 1
- 239000011675 vitamin B5 Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
- A23L17/70—Comminuted, e.g. emulsified, fish products; Processed products therefrom such as pastes, reformed or compressed products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/312—Foods, ingredients or supplements having a functional effect on health having an effect on dental health
Abstract
Description
The present invention relates to a composition for dental-alveolar bone and a functional food containing the same, and more particularly to a dental-alveolar bone (alveolar bone) for improving the health of teeth and alveolar bone, And a functional food containing the same.
The teeth are supported by periodontal tissue present around the teeth. The tooth itself has a hard tissue called an enamel of the outer layer and a dentin of the inner layer. The periodontal tissue is based on a bone called alveolar bone, and has gingival and periodontal ligaments. The tooth is lost by the disease of the tooth itself, and the tooth is lost by the periodontal disease. Further, if the alveolar bone melts, it becomes difficult to support the teeth, and implantation of the implants becomes difficult.
Therefore, the health of the teeth as well as the alveolar bone is very important. Bone tissues such as teeth and alveolar bone have two specific functions, osteoblasts and osteoclasts. Osteoblasts play a role in synthesizing and filling bone matrix, while osteoclasts play a role in absorbing bone. In normal adults, the balance between osteoblasts and osteoclasts is maintained. That is, a balance is maintained between the amount of bone formation and the amount of bone resorption in a normal adult.
The number of patients suffering from dental and periodontal diseases due to poor nutrition and metabolic disturbance due to poor eating habits and aging of modern society is increasing. Currently, many preventive / therapeutic agents that can prevent or treat periodontal disease have been developed. However, periodontal disease prevention / treatment products made of synthetic materials can cause adverse effects by the use of antibiotics and are difficult to take for a long time.
Recently, techniques for preventing / treating periodontal disease using natural extracts such as natural products such as cinnamon, lucidum, persimmon, red ginseng, shiitake, and green tea have been attempted. For example, Korean Patent No. 10-0431170, Korean Patent Laid-Open No. 10-2012-0117387, and Korean Patent Laid-Open No. 10-2013-0056701 disclose techniques related to the above.
However, the composition disclosed in the prior patent documents is a foodstuff based on natural materials as a main component, but is a composition for anti-inflammation, antibacterial and deodorization in the oral cavity, which is hardly effective for bone health of teeth and alveolar bone.
Accordingly, it is an object of the present invention to provide a dental-alveolar bone composition and a functional food containing the dental-alveolar bone composition, which are physically stable and improve the health of teeth and alveolar bone effectively.
According to a first aspect of the present invention, there is provided a tooth-alveolar bone composition comprising at least one selected from the group consisting of pulverized products and extracts of pollock hair as an active ingredient for improving the health of teeth and alveolar bone.
Further, according to a second aspect of the present invention, there is provided a tooth-alveolar bone composition comprising the following (1) to (4) as an effective ingredient for improving the health of teeth and alveolar bone.
(1) at least one selected from ground water and extract
(2) at least one selected from pulverized water and extract of soybean
(3) at least one selected from ground water and extract
(4) at least one selected from crushed water and extract of safflower seed
According to a preferred embodiment, the composition for a tooth-alveolar bone according to the present invention comprises:
(1) 60 to 80% by weight of at least one selected from the group consisting of ground water and extracts;
(2) 10 to 30% by weight of at least one selected from pulverized products and extracts of soybean;
(3) 0.5 to 15% by weight of at least one selected from wheat flour and extract; And
(4) 0.2 to 10% by weight of at least one selected from pulverized water and extract of safflower seed.
In addition, the composition for a dental-
(5) one or more vitamin components selected from vitamins and salts thereof; And
(6) palatinose.
According to an exemplary embodiment, the pollock head may be at least one selected from the head and head.
In addition, the present invention provides a functional food comprising the composition for tooth-alveolar bone according to the present invention. The functional food according to the present invention may have a formulation such as, for example, a pill or a granule.
INDUSTRIAL APPLICABILITY According to the present invention, it is possible to improve the health of the teeth and the alveolar bone in a foodstuff stably by containing at least pollack hair (Corynebyna and / or Corynebactra) as an effective ingredient.
As used herein, the term "and / or" is used to include at least one of the preceding and following elements. The term "one or more" as used in the present invention means one or more than two. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS In the following description of the present invention, a detailed description of known general functions and / or configurations will be omitted.
The present invention provides a tooth-alveolar bone composition (hereinafter abbreviated as "composition") that improves the health of teeth and alveolar bone. The composition according to the present invention is an effective ingredient for improving the health of teeth and alveolar bone, and includes at least polish hair. The present invention provides a new use of pollock hair in another aspect. That is, according to the present invention, polish hair is effective for improving the health of teeth and alveolar bone.
According to a preferred embodiment, the composition according to the present invention is an effective ingredient for improving the health of teeth and alveolar bone, and includes four components (raw materials) of (1) pollack hair, (2) beans, (3) . In the present invention, each of the above components, namely (1) pollack hair, (2) soybean, (3) raspberry and (4) safflower seed are included in the composition of the present invention in the form of pulverized products and / or extracts.
Specifically, the composition according to the present invention may contain, according to a preferred form, at least one selected from the group consisting of (1) a ground water and an extract thereof, (2) at least one selected from pulverized products and extracts of soybean, (3) And (4) at least one selected from the pulverized material and the extract of safflower seed as an active ingredient for improving the health of the teeth and the alveolar bone. According to the present invention, the above-mentioned four components (raw materials) selected from natural products are contained, and the health of teeth and alveolar bone is effectively improved while being pharmacologically stable.
The term " improvement of teeth and alveolar bone health "as used in the present invention means that the tooth and alveolar bone are made robust so as to be useful for their health, for example, prevention / treatment of periodontal disease, Activation of osteoblasts, promotion of bone calcification, enhancement of immunity, nutrition, and / or activation of metabolism, and the like.
In the present invention, when the four components are included in the composition of the present invention in the form of a pulverized product, the size of the pulverized product is not limited. The pulverized product may have a size of, for example, 0.1 to 5 mm, and more specifically, may have a size of 5 to 2 mm, but is not limited thereto. In addition, the pulverization method of each component is not limited, and it can be carried out by a method such as a ball mill, a rotary mill and a vibration mill.
In the present invention, when each of the four components is contained in the composition of the present invention in the form of an extract, the extract includes a liquid phase, an oil phase and / or a powder phase. The extract can be obtained by various extraction methods, for example, by solvent extraction using water and / or an organic solvent or extraction through compression. In one example, in the case of the solvent extraction, one or two or more mixed extraction solvents selected from water, anhydrous or hydrated lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol, etc.) In the present invention, the extract is included in the present invention as long as it exhibits substantially the same effect using the above-described extraction solvent as well as other extraction solvents.
In addition, in the present invention, the above-mentioned extract includes not only an extract by an extraction solvent but also an extract obtained through a purification process. Specifically, the extract can be obtained by extracting a liquid phase using an extraction solvent as it is, or extracting it and purifying it, for example, separating a membrane such as an ultrafiltration membrane having a certain molecular weight cut-off value, , A method of separation by hydrophobic or affinity-based separation), or the like may be used. In addition, the extract is obtained by concentrating the extract solution obtained by solvent extraction as described above under reduced pressure; Powders obtained through additional processes such as vacuum distillation and drying (such as freezing or spray drying); And a dilution solution in which the powder is diluted with a solvent, and the like, and may be included in the composition according to the present invention.
According to another aspect of the present invention, the composition according to the present invention may further comprise (5) at least one vitamin component selected from vitamins and salts thereof, and (6) palatinose. The components (raw materials) of (1) to (6) will be described as follows.
(1) pollock head
In the present invention, the pollock hair includes a head of dried pollack and / or a head of ecology, which can be selected, for example, from the head of a dried pollack. According to one embodiment, the pollock hair can be advantageously used with curly hair and / or hairless hair.
In general, pollack is richer in protein and calcium than other fish, has fewer cholesterol, and has a higher nutritional value, which is known to activate the body's metabolism and clear the hair. In particular, it contains more than three times more protein than ecology, and contains a lot of calcium, phosphorus, and potassium. It also contains methionine, lysine, tryptophan, It contains a lot of essential amino acids, so it is known to help reduce hangover, control cardiovascular and antioxidant effects, and lower blood cholesterol levels. Also, in oriental medicine, the North Korean and the Chinese persimmon are classified as a good food for a person whose digestive function is weak and whose hands and feet are warm because of their warm nature.
According to the present invention, it can be seen that, among the various parts of the teeth, the teeth and the alveolar bone improve the health of the head and the alveolar bone. That is, according to the present invention, it is possible to provide a method for the treatment of periodontal disease, such as antibacterial activity against periodontal disease bacteria, promotion of osteoblast proliferation, promotion of osteoblast differentiation, formation of bone lime, and / And thus the health of the teeth and alveolar bone is effectively improved. This can be confirmed by the following examples.
(2) Soybean
In general, beans are rich in calcium and are known for good bone health. In the present invention, soybean is used for the purpose of enhancing immunity and / or nutritional supplement as well as supplementing calcium. In the present invention, the soybeans are not particularly limited as long as they belong to the soybean family, and they can be selected from, for example, soybean and / or seabream.
(3)
It is a herbaceous plant of perennial herb that belongs to the Bacillus subtilis. It works to smooth blood circulation and remove eosinophilia. It is used for the treatment of physiological impurity, postpartum abdominal pain, and it works well in organs such as liver and kidney. . In addition, it is known that astringent analgesic action is strong and enhances immune function.
In the present invention, the above-mentioned mist can be used as the roots, stems and / or leaves of the above-mentioned mist, preferably the mist roots. In the present invention, the mist is used for immunity and / or anti-inflammatory action and the like.
(4) safflower seed
Safflower is a one-year-old herb that belongs to Asteraceae, and safflower seeds have been used as a diuretic for the treatment of bone diseases such as osteoporosis, osteoporosis, and osteogenesis. In addition, safflower seeds contain serotonin compounds with excellent antioxidative effects, acacetin as a flavonoid ingredient and lignan compounds as effective against bone diseases. Has been reported to have an effect of improving lipid metabolism as well as therapeutic effect.
In the present invention, safflower seeds are used for the above-mentioned effects. In addition, in the present invention, safflower seeds can be selected from dried safflower seeds and / or germinated safflower seeds.
(5) Vitamin Components
In the present invention, the vitamin component is an ingredient that can be optionally added, which is added for nutrition, antioxidation, and / or activation of metabolism and the like. The vitamin component may use one or more selected from vitamins and salts thereof. The vitamins may be selected from water-soluble and / or fat-soluble vitamins.
According to a preferred embodiment, the above vitamin components are vitamin C, vitamin E, nicotinic amide (vitamin B3), vitamin A, calcium pantothenate (vitamin B5), vitamin B6 hydrochloride, vitamin B1 hydrochloride, vitamin B2, folic acid, powder Vitamin D3, biotin, and vitamin B12. When all 12 kinds of vitamin components are included, it is preferable to improve the health of teeth and alveolar bone.
(6) Palatinos
In the present invention, palatinose is a component which can be optionally added, and is preferably contained in the composition according to the present invention. The palatinose may act as a nutritional and sweetening agent in compositions according to the present invention. In addition, the palatinose has a cavity-preventing effect and is useful in the present invention.
(1) 60 to 80% by weight of at least one selected from the pulverized products and extracts of pollack barley, (2) pulverization of the beans (3) 0.5 to 15% by weight of at least one selected from the pulverized material and the extract of the wheat, and (4) at least one selected from the pulverized material and the extract of the safflower seed May be contained in an amount of 0.2 to 10% by weight. At this time, the content (% by weight) of each component is based on the dry weight of the entire composition. In addition, the vitamin (5) and (6) palatinose may be contained in an amount of, for example, 0.01 to 5% by weight based on the total composition (dry weight) of the composition. When the content is out of the above range and the content is low, the effect of the use of the component is insignificant, and when the content is high, the content of the other component is low, have.
The composition according to the present invention is applied as a food and / or pharmaceutical composition, orally (dosed). The composition according to the present invention can be formulated in the form of a general food and / or pharmaceutical product. The composition according to the present invention can be formulated into, for example, a suspension, a syrup, a tablet, a pill, a powder, a granule and / or a capsule. In addition, the composition according to the present invention may contain excipients for formulation, for example starch, calcium carbonate, sucrose, lactose and / or gelatin. The composition according to the present invention may further comprise, for example, fillers, extenders, binders, wetting agents, disintegrating agents and / or diluents as food and / or pharmaceutically acceptable additives. In addition, the composition according to the present invention can be used as a food additive.
Meanwhile, the functional food according to the present invention may be at least those containing the composition of the present invention as described above. In the present invention, "functional" means a function for improving the health of teeth and alveolar bone as described above. The functional food according to the present invention may have formulations such as suspensions, syrups, tablets, pills, powders, granules and / or capsules, and specific examples include pills, granules and / or capsules It can have a formulation. In addition, the functional food according to the present invention can be sterilized and hermetically packaged and supplied to consumers for minimizing quality change (preventing penetration of external air and moisture, inhibiting growth and growth of microorganisms), and the like. Films such as PET (polyethylene terephthalate), PE (polyethylene) and / or PP (polypropylene) may be used for the packaging.
Hereinafter, examples and comparative examples of the present invention will be exemplified. The following examples are provided to illustrate the present invention in order to facilitate understanding of the present invention, and thus the technical scope of the present invention is not limited thereto. In addition, the following comparative example is not meant to be a prior art, but is provided for comparison with an embodiment only.
[Example 1]
≪ Preparation Example 1 >
The water was washed several times in running water and dried thoroughly for 60 minutes with hot air at about 80 ° C. Thereafter, the head was separated from the hot air-dried drum, and the separated hair was finely cut and then pulverized through a hand mixer. The pulverized northern hair was put into an extraction vessel equipped with a stirrer, and then solvent (60 wt% aqueous solution of ethanol) was added thereto, followed by solvent extraction under stirring at 24O < 0 > C for 24 hours. At this time, pulverized Cow head and solvent were added to the extraction vessel at a weight ratio of 1:10.
Next, the residue (solid content) was removed by filtration to obtain a curd head extract. The obtained Curd Curd extract was put into a vacuum concentrator and concentrated under reduced pressure at about 70 ° C to remove the solvent. The extracts of Corynebacterium brassicae were obtained.
≪ Preparation Example 2 >
The water was washed several times in running water and dried thoroughly for 60 minutes with hot air at about 80 ° C. Thereafter, the head was separated from the hot air-dried drum, and the separated hair was finely cut and then pulverized through a hand mixer.
Next, the pulverized North hair was finely pulverized using a ball mill, and then the finely pulverized pulverized material was classified through sieving to obtain a butterfly having an average particle size distribution of about 40 μm A hair pulverized product was obtained.
<Experimental Example 1> Evaluation of antibacterial activity
To evaluate the antimicrobial activity against the periodontal disease pathogens of the obtained Corynebra extract and Corynebacterium crassifolia, the following experiment was conducted using a conventional liquid medium dilution method.
First, Porphyromonas gingivalis (ATCC 53978), a typical periodontal disease, was used as a pathogen. Trypticase soy broth (TSB) was used as the culture medium.
After culturing the pathogens in the liquid medium, the cultured microbial culture was divided into several microplates at a rate of about 100 쨉 l each. To each microplate was added the obtained Corynebra extract and Corynebacterium crassifolia according to concentration to determine the degree of pathogen culture The absorbance was measured at 590 nm according to a conventional method. In addition, the inhibition rate (%) of the growth inhibition of the control group was evaluated using a control group in which no corydalen hair extract or curd head was added. That is, the inhibition rate (% of control) of periodontal bacteria growth in each experimental group was evaluated according to the concentration of Coleoptera and Coleoptera according to the following formula 1, and the results are shown in Table 1 below.
[Equation 1]
Growth inhibition rate (%) = [(number of bacteria in the control group - absorbance of the test group) / absorbance of the control group] x 100
As shown in [Table 1], it was found that the extract of Curculusa burder and the pulverized product had antibacterial activity against periodontal disease bacteria. In addition, it was found that the antibacterial activity of the extracts and the pulverized product of Curcuma larvae were significantly affected by the concentration.
In addition, the extracts of Corynebactii, which showed good results in the evaluation of the antibacterial activity, were tested for proliferation, differentiation and bone calcification according to a conventional method as follows. In the following experiment, MC3T3-E1 cells were used as osteoblast-derived osteoblasts derived from mouse calvaria. As a medium for cell culture, a medium of α-MEMα-minimum essential medium containing 10 wt% fetal bovine serum (FBS) and 1 wt% antibiotic (penicillin-streptomycin) 2 < / RTI > conditions.
<Experimental Example 2> Evaluation of proliferation rate of osteoblast
To determine the extent of osteoblast proliferation, MTT tetrazolium (MTT) was first eluted with 3- (4,5-dimethyl-2-thiazolyl) -2,5-diphenyl-2H-tetrazolium bromide The degree of reduction of purple to insoluble formazan was measured at 570 nm and measured by MTT assay to determine survival rate of living cells. That is, 100 μl of MC3T3-E1 cells were added to a 96-well plate at a concentration of 1 × 10 4 cells / well, and cultured in an incubator for 24 hours. Then, the medium was removed and the hair extract was distributed to the medium without FBS And the new culture was dispensed.
Thereafter, the medium was removed for 48 hours, and the MTT reagent (10 μl / well) at a concentration of 0.05 mg / ml was dispensed. After further incubation for 4 hours, the culture solution was removed and the precipitate was dissolved in DMSO Absorbance was measured at 570 nm using a microplate reader. The control group was cultured in a medium containing no bark hair extract, and the proliferation rate (%) of osteoblasts was evaluated based on the absorbance of the control group (100%). The results are shown in Table 2 below.
As shown in [Table 2], it can be seen that the Coleoptera extract effectively propagates osteoblasts involved in the formation of bone tissue.
<Experimental Example 3> Evaluation of differentiation rate of osteoblast
Alkaline phosphatase activity (ALP activity), an osteoblast differentiation marker, was evaluated as follows.
MC3T3-E1 cells were added to each of 6 well plates at a concentration of 1 × 10 5 cells / well. After incubation for 24 hours in an incubator, the medium was removed and 10wt% fetal bovine serum (FBS) and 1wt% antibiotic penicillin-streptomycin) was distributed to the? -MEM medium and the new culture was dispensed. After culturing for 6 days, the culture medium was removed, and 0.1 wt% Triton X-100 was added to separate the cells. The suspension of the cells was shaken at 180 rpm in a shaking incubator at 4 캜 for 10 minutes, and centrifuged to take only the supernatant. Then, the amount of p-nitrophenol (p-NP) hydrolyzed from p-nitrophenyl phosphate was measured using an ALP kit, and the activity was determined. The enzyme activity per unit protein content was calculated by dividing the activity by the amount of protein. That is, 50 μl of 1 ml of the supernatant was added to a 96-well plate, and pNPP stock solution (pNPP stock solution diluted 100 times with 2X assay buffer, pNPP stock solution: 250 μl of distilled water was dissolved in pNPP vial 50 μl of the solution was added to all wells for 30 minutes at room temperature. Finally, 50 μl of a stop solution was added to each well to terminate the reaction. After that, the reaction was terminated by using a microplate reader, and the absorbance at 405 nm Were measured. Protein content was measured using a bovine serum albumin protein assay reagent, and enzyme activity was expressed as a percentage of the control. The results are shown in Table 3 below.
(Differentiation rate of osteoblast)
As shown in the above Table 3, the ALP activity was evaluated, and it was found that the Coleoptera extract was concentration-dependent and significantly increased ALP activity. Since ALP is a marking factor expressed in the differentiation of osteoblasts, it can be understood that the extract of Coleoptera promotes osteoblast differentiation.
<Experimental Example 4> Evaluation of bone calcification in osteoblasts
To determine the degree of calcification of osteoblast cells, the following evaluation was made according to the Alizarin-red staining method.
MC3T3-E1 cells were added to several 6-well plates at a concentration of 1 × 10 5 cells / well. After incubation for 24 hours in an incubator, the medium was removed and 50 μg ascorbic acid, 10 mM β-glycerol phosphate The culture medium containing 10 μg / ml of bark extract extract was dispensed into the culture medium and cultured in an incubator for 5 days, 10 days, and 20 days. After incubation, the medium was removed, washed with PBS, and fixed with 70 wt% ethanol for 1 hour at 4 ° C. The alizarin red (AR) solution was prepared by dissolving alizarin red in distilled water, adjusting the concentration to 40 mM and adjusting the pH to 4.2. The cells were fixed and stained with alizarin red (AR) solution (2 ㎖ / well) for 10 min. After washing 5 times with distilled water, the unstained portion was removed by washing with PBS and the degree of calcification was observed under a microscope.
Next, after confirming the formation of calcification, 2 ml of 10 mM sodium phosphate (pH 7.0) solution to which 10 wt% cetylpyridinium chloride was added was added to the wells for dissolving for 15 minutes. The degree of staining was measured using a microplate reader The absorbance at 570 nm was measured and the bone formation capacity was evaluated as a percentage based on the absorbance of the control group. The results are shown in Table 4 below.
As shown in the above Table 4, it can be seen that the extract of Coleoptera promotes bone calcification of osteoblasts. In addition, the ability to form bone calcification increased with time. Bone calcification is an important marker for osteoblast differentiation. Alizarin is stained in the matrix of mineralized cells, so the amount of calcification and the degree of dyeing are mutually in proportion. Therefore, it can promote bone calcification and formation of osteoblast, and promote osteoblast differentiation.
[Example 2]
Bee hair, soybean (seaweed), wool (roots) and safflower seeds were prepared, washed several times with water, and then thoroughly dried through hot air. The dried four kinds of raw materials were put into a pulverizer in an appropriate amount so as to have a content (based on dry weight) as shown in Table 5, and then mixed and pulverized. Next, the mixed pulverized product was put in a ventilator, and then subjected to compression molding to produce spherical pills (functional food). Thereafter, the prepared pills were sterilized.
[Example 3 and Example 4]
Except that the additive 1 (Example 3) and the additive 2 were added in addition to the four raw materials of Example 2 to prepare a spherical pellet (functional food). At this time, 12 kinds of vitamin components were added as the additive 1 in Example 3, and 12 kinds of vitamin components were added as the additive 2 in Example 4. The specific components and contents of the specimens according to the respective Examples are as shown in Table 5 below.
[Example 5]
A spherical pellet (functional food) was prepared in the same manner as in Example 4 except that the Curcuma longa extract (powder) obtained in the same manner as in Example 1 was used instead of the Curcuma pea extract. The specific components and contents of the specimen according to Example 5 are as shown in Table 5 below.
[Comparative Example 1]
Compared with the above-mentioned Example 2, the same procedure was carried out, except that the Cowpea head pulverization product was not used as the raw material. The specific components and contents of the specimen according to Comparative Example 1 are as shown in Table 5 below.
(Ground water / extract)
(Seoritee)
(Root)
Additive 2: Combination of palatinose and vitamins (a mixture of vitamin C, vitamin E, nicotinamide, vitamin A, calcium pantothenate, vitamin B6 hydrochloride, vitamin B1 hydrochloride, vitamin B2, folic acid, powdered vitamin D3, biotin and vitamin B12) 1: 5 mixture
≪ Experimental Example 5 >: Evaluation of improvement of tooth and periodontal condition
The pills according to Example 4 and Comparative Example 1 were administered to a subject twice a day, ten times a day, and evaluated for improvement in tooth and periodontal condition two months after administration. The subject was a chronic periodontal disease patient, and 20 subjects (10 persons taking the sample of Example 4 and 10 people taking the sample of Comparative Example 1) aged 55 to 65 years were enrolled. The degree of improvement was evaluated on a 5-point scale according to the following evaluation criteria, and the average value of the results was shown in Table 6 below.
<Evaluation Criteria>
1 point: Not at all
2 points: None
3 points: Normal
4 points: a little
5 points: Yes
As shown in the above Table 6, the test piece according to Example 4, which contains the bean curd according to the present invention, is more effective for improving the health of the tooth than Comparative Example 1 in which the soybean content is generally good for bone health Respectively.
Claims (5)
(1) at least one selected from ground water and extract
(2) at least one selected from pulverized water and extract of soybean
(3) at least one selected from ground water and extract
(4) at least one selected from crushed water and extract of safflower seed
The composition for a dental-
(1) 60 to 80% by weight of at least one selected from the group consisting of ground water and extracts;
(2) 10 to 30% by weight of at least one selected from pulverized products and extracts of soybean;
(3) 0.5 to 15% by weight of at least one selected from wheat flour and extract; And
(4) 0.2 to 10% by weight of at least one selected from ground water and extracts of safflower seed.
The composition for a dental-
(5) one or more vitamin components selected from vitamins and salts thereof; And
(6) A composition for dental-alveolar bone, further comprising palatinose.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002501786A (en) * | 1998-01-28 | 2002-01-22 | リジェネレーション テクノロジーズ インク． | Irradiated and heat treated bone paste |
| KR100431170B1 (en) | 2003-06-11 | 2004-05-12 | 신화제약 (주) | Compositions for Dental Clinic Comprising Extracts of Plant |
| KR20120117387A (en) | 2011-04-15 | 2012-10-24 | 주식회사 자이월드 | Oral care preventive and prophylactic composition |
| KR20130056701A (en) | 2011-11-22 | 2013-05-30 | 주식회사 피비에스 | Composition for antiinflammatory, antibacterial and removing stench comprising red ginseng extracts and extracts derived from natural materials |
| KR101517095B1 (en) * | 2014-12-03 | 2015-05-04 | 주식회사 제이앤케이 글로벌리소스 | Periodontal diseases treatment and prevention composition using the natural extracts |
-
2015
- 2015-06-15 KR KR1020150084431A patent/KR101665093B1/en active IP Right Grant
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002501786A (en) * | 1998-01-28 | 2002-01-22 | リジェネレーション テクノロジーズ インク． | Irradiated and heat treated bone paste |
| KR100431170B1 (en) | 2003-06-11 | 2004-05-12 | 신화제약 (주) | Compositions for Dental Clinic Comprising Extracts of Plant |
| KR20120117387A (en) | 2011-04-15 | 2012-10-24 | 주식회사 자이월드 | Oral care preventive and prophylactic composition |
| KR20130056701A (en) | 2011-11-22 | 2013-05-30 | 주식회사 피비에스 | Composition for antiinflammatory, antibacterial and removing stench comprising red ginseng extracts and extracts derived from natural materials |
| KR101517095B1 (en) * | 2014-12-03 | 2015-05-04 | 주식회사 제이앤케이 글로벌리소스 | Periodontal diseases treatment and prevention composition using the natural extracts |
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