KR101619410B1 - A loyphiled ginseng containing vitamins and herb medicines and the producing method thereof - Google Patents
A loyphiled ginseng containing vitamins and herb medicines and the producing method thereof Download PDFInfo
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- KR101619410B1 KR101619410B1 KR1020150052385A KR20150052385A KR101619410B1 KR 101619410 B1 KR101619410 B1 KR 101619410B1 KR 1020150052385 A KR1020150052385 A KR 1020150052385A KR 20150052385 A KR20150052385 A KR 20150052385A KR 101619410 B1 KR101619410 B1 KR 101619410B1
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- vitamin
- ginseng
- weight
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- aqueous solution
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Abstract
Description
본 발명은 체내 에너지대사의 활성화, 간기능보호, 항산화 효능, 피로회복 등에 뛰어난 효능을 지닌 수용성 비타민과 헛개열매, 인진쑥, 감초로 이루어진 생약재성분이 함유된 동결건조인삼 및 그 제조방법에 관한 것으로서, 더욱 상세하게는 수삼을 수세하고 선별하여 일정두께를 지닌 절편상태로 절단하거나 세근을 절단제거한 원형삼 형태의 수삼을 준비하는 전처리단계와, 수용성 비타민 C와 비타민 B군 복합체를 정제수에 일정비율로 용해시켜 비타민수용액을 제조하는 단계와, 헛개열매와 인진쑥과 감초를 일정비율로 혼합하고 물추출하여 생약재추출액을 제조하는 단계와, 비타민수용액과 생약재추출액을 일정비율로 혼합한 혼합수용액에 전처리된 수삼을 25 ~ 55℃의 온도에서 40 ~ 60시간 동안 침지시키거나 혼합수용액을 전처리된 수삼에 분사방식으로 일정량 도포하여 피막을 형성하는 혼합수용액처리단계와, 혼합수용액으로 처리된 수삼을 동결건조시켜 수분함량이 5중량% 이하가 되도록 수분을 제거하면서 수분제거에 따른 미세공극의 형성으로 혼합수용액의 유효성분이 수삼 내부로 침투하여 흡착되도록 하는 동결건조단계를 통해 제조되는 것을 특징으로 하는 비타민과 생약재성분이 함유된 동결건조인삼 및 그 제조방법에 관한 것이다.
The present invention relates to a freeze-dried ginseng containing water-soluble vitamins having excellent effects on the activation of energy metabolism in the body, protection of liver function, antioxidative efficacy and fatigue recovery, and herbal medicines comprising hornbug, horseradish, and licorice, More particularly, the present invention relates to a method for preparing ginseng, which comprises washing a raw ginseng with water, sorting the ginseng into pieces having a predetermined thickness, cutting the fine roots, and preparing a raw ginseng form of the ginseng, and dissolving the water- A step of preparing an aqueous solution of vitamins, a step of preparing a herbal medicine extract by mixing the hull fruit with Artemisia capillaris and licorice at a certain ratio, and a step of mixing the vitamin A aqueous solution with the herbal medicine extract to prepare a mixed aqueous solution of 25 At a temperature of ~ 55 ° C for 40 to 60 hours, or by spraying the mixed aqueous solution onto pretreated fresh ginseng A step of treating the mixed aqueous solution to form a film by applying a predetermined amount of water; and a step of lyophilizing the ginseng treated with the mixed aqueous solution to remove water such that the water content is less than 5% by weight, Dried ginseng containing vitamins and herbal medicines, and a method for preparing the same. The present invention also relates to a method for preparing the freeze-dried ginseng.
일반적으로 인삼은 오래전부터 사용되어온 대표적인 자양강장제이며 그 함유 성분에 대한 약리학적 연구가 많이 이루어지고 있으며, 고지혈증의 개선, 간 기능 강화, 항스트레스 효과, 면역 증강, 뇌기능 개선, 항암 효과 등 다양한 효능을 나타내고, 인체의 항상성을 유지하는 역할을 하며, 또한 최근에는 많은 연구자들이 인삼에 함유된 미량 진세노사이드의 약리효과 및 그 메카니즘에 대해 연구하고 있다.
In general, ginseng has been used for a long time as a representative nourishing tonic agent. Many pharmacological studies have been conducted on the ingredients of the ginseng, and it has been shown that various effects such as improvement of hyperlipidemia, liver function enhancement, antistress effect, immune enhancement, brain function improvement, And maintains the homeostasis of the human body. Recently, many researchers are studying the pharmacological effect and the mechanism of the micro ginsenoside contained in ginseng.
인삼은 가공방법에 따라 수삼, 백삼, 홍삼, 흑삼 등으로 나눌 수 있는데, 밭에서 수확한 상태의 수분이 다량 함유된 삼은 수삼이며, 이를 일반 건조한 것이 백삼, 고온에서 수증기로 1 ~ 3회 증숙한 것이 홍삼이고, 아홉 번 증숙과정을 거친 것이 흑삼으로 알려져 있으며, 홍삼은 수삼을 가열 처리하여 제조되는 것으로 백삼에 비하여 우수한 약효를 나타내는 것으로 알려져 있고 수삼이나 백삼에 함유되지 않은 진세노사이드가 다량 존재하여 그 약효가 증대되는 것으로 알려져 있으나, 수삼 등을 가공하여 효능이 증강된 홍삼이나 흑삼 등을 얻기 위해서는 고온 또는 고압 처리를 수차례 반복해야 하는 번거로움이 있고 많은 시간이 소요되는 문제점이 있었다.
Ginseng can be classified into ginseng, white ginseng, red ginseng, and black gins according to the processing method. The ginseng, which contains a large amount of water harvested in the field, is generally dried ginseng, white ginseng, steamed at high temperature 1 to 3 times It is known that black ginseng has undergone nine steaming processes, and that red ginseng is produced by heat treatment of ginseng, which is known to exhibit superior pharmacological activity compared to white ginseng. There is a large amount of ginsenosides not contained in ginseng or white ginseng However, there is a problem that it takes a lot of time to process the high-temperature or high-pressure treatment several times in order to obtain red ginseng and black ginseng which have enhanced efficacy by processing ginseng and the like.
이러한 문제점을 개선하기 위한 종래기술로서 대한민국 등록특허공보 등록특허 제 10-0864471호에서는 인삼, 백출, 백복령, 감초, 숙지황, 백작약, 천궁, 당귀, 황기, 육계의 추출물 증기로 인삼을 3회 이상 증숙시켜 얻어지는 진세노사이드 Rg1 함량이 증가된 가공 인삼을 제공하되, 상기 인삼, 백출, 백복령, 감초, 숙지황, 백작약, 천궁, 당귀, 황기, 육계는 인삼 9.26중량%, 백출 9.26중량%, 백복령 9.26중량%, 당귀 9.26중량%, 천궁 9.26중량%, 숙지황 9.26중량%, 생강 7.41중량%, 대추 7.41중량%, 작약 9.26중량%, 황기 7.41중량%, 육계 7.41중량%, 감초 5.54중량%의 비율로 혼합된 것임을 특징으로 하는 가공 인삼이 개시되어 수삼을 증숙하는 과정에서 생약재 추출액을 가하여 증숙함으로써 피로회복, 항스트레스, 기억 및 학습기능 증진 효과가 뛰어난 진세노사이드 Rg1의 함량을 증가시킨 가공 황삼을 제공하였다.
As a conventional technique for improving the above problems, Korean Patent Registration No. 10-0864471 discloses a method of extracting ginseng more than three times as an extract steam of ginseng, white liquor, white roe, licorice, Ginseng, liquorice, white roe, licorice root, white liquorice, white roe, chrysanthemum, ginseng, hwanggi, broiler chrysanthemum are 9.26% by weight of ginseng, 9.26% by weight of liquorice, 9.26% by weight of Baekbokryeong , 9.26% by weight of Angelica gigas Nakai, 9.26% by weight of Angelica gigas Nakai, 9.26% by weight of Ginger root, 7.41% by weight of Ginger, 7.41% by weight of Jujube, 7.42% The content of ginsenoside Rg1, which is excellent in fatigue recovery, anti-stress, memory and learning function, is improved by adding an extract of herbal medicine to the raw ginseng in the course of mixing ginseng. It provided the visibility Kindle processing hwangsam.
그러나, 상기 종래기술은 십전대보탕으로 알려진 대표적인 한의학상의 처방으로 사용되는 생약재 10가지를 추출하여 그 추출물의 증기로 인삼을 증숙시키도록 되어 있어 증숙과정만으로는 생약재의 유효성분이 인삼에 제대로 침투되거나 흡착되지 않으며, 또한 십전대보탕의 생약재 성분이 간수치가 높거나 간질환 등이 있는 사람, 임산부나 고혈압 환자 등에게는 부작용이 발생되어 건강보조식품으로의 취식이 극히 제한적인 문제점이 있었다.
However, in the above-mentioned prior art, 10 kinds of herbal medicines used as a typical oriental medicine prescription which is known as Dixi Daibo Betamong are extracted and the ginseng is steamed by the steam of the extract, so that the effective ingredient of the herbal medicine is not well penetrated or adsorbed In addition, there is a problem that the preparation of health supplement is extremely limited due to the side effects of the herbal medicines of Dixi Daebeungbang, such as high hepatic blood flow, liver disease, pregnant women and hypertensive patients.
본 발명은 상기와 같은 문제점들을 개선하기 위한 것으로 수용성 비타민인 비타민 C와 비타민 B군 복합체를 일정비율로 정제수에 용해시켜 비타민수용액을 제조하고 헛개열매와 인진쑥과 감초를 일정비율로 혼합하고 물추출하여 생약재추출액을 제조하여 비타민수용액과 혼합한 다음 혼합수용액을 전처리된 수삼에 침지처리하거나 도포하고 동결건조하여 수분제거에 따른 미세공극의 형성으로 혼합수용액의 유효성분이 수삼 내부로 침투하면서 흡착되도록 함으로써 인삼의 기본적인 효능과 더불어 체내 에너지대사의 활성화, 간기능보호, 항산화 효능, 피로회복 등에 뛰어난 효능을 지닌 비타민 C와 비타민 B군 복합체 및 헛개열매와 인진쑥과 감초의 유효성분이 함침된 동결건조인삼을 제공하는 것에 그 목적이 있다.
Disclosure of Invention Technical Problem [8] In order to solve the above problems, the present invention is to solve the above-mentioned problems by preparing a vitamin aqueous solution by dissolving vitamin C and vitamin B complexes, which are water-soluble vitamins, in purified water in a certain ratio, mixing the horseradish, The mixed aqueous solution is mixed with the aqueous vitamin solution, and the mixed aqueous solution is immersed or pretreated in the pretreated fresh ginseng and lyophilized to form the micropores upon the removal of water, so that the active ingredient of the mixed aqueous solution penetrates into the ginseng while being adsorbed. Freeze-dried ginseng having basic effects, vitamin C and vitamin B complexes having excellent effects on activation of the body's energy metabolism, liver function protection, antioxidative efficacy and fatigue recovery, and freeze-dried ginseng impregnated with horseradish, It has its purpose.
이러한 목적을 달성하기 위하여 수삼을 수세하고 선별하여 일정두께를 지닌 절편상태로 절단하거나 세근을 절단제거한 원형삼 형태의 수삼을 준비하는 전처리단계와, 수용성 비타민 C와 비타민 B군 복합체를 정제수에 일정비율로 용해시켜 비타민수용액을 제조하는 단계와, 헛개열매와 인진쑥과 감초를 일정비율로 혼합하고 물추출하여 생약재추출액을 제조하는 단계와, 비타민수용액과 생약재추출액을 일정비율로 혼합한 혼합수용액에 전처리된 수삼을 25 ~ 55℃의 온도에서 40 ~ 60시간 동안 침지시키거나 혼합수용액을 전처리된 수삼에 분사방식으로 일정량 도포하여 피막을 형성하는 혼합수용액처리단계와, 혼합수용액으로 처리된 수삼을 동결건조시켜 수분함량이 5중량% 이하가 되도록 수분을 제거하면서 수분제거에 따른 미세공극의 형성으로 혼합수용액의 유효성분이 수삼 내부로 침투하여 흡착되도록 하는 동결건조단계를 통해 제조되는 것에 본 발명의 특징이 있다.
In order to achieve the above object, the present invention provides a method for preparing ginseng, which comprises washing a ginseng with water, sorting the ginseng into a slice having a predetermined thickness, preparing a ginseng form of round ginseng in which the fine roots are cut off and preparing a water-soluble vitamin C and a vitamin B- A step of preparing an aqueous solution of vitamin A by mixing the hull fruit with a certain ratio of horse mackerel and liquorice and extracting water to prepare a mixed aqueous solution of vitamin A and herbal medicine extract at a certain ratio, Is immersed at a temperature of 25 to 55 ° C for 40 to 60 hours, or a mixed aqueous solution is treated by spraying a predetermined amount of the mixed aqueous solution on the preprocessed ginseng to form a film; and a step of lyophilizing the ginseng treated with the mixed aqueous solution The water content is reduced to 5% by weight or less while the moisture is removed, There are features of this invention as effective component in an aqueous solution prepared from the freeze-drying step such that the adsorption and penetration into the fresh ginseng.
상기와 같이 본 발명에 의하면 수용성 비타민인 비타민 C와 비타민 B군 복합체를 일정비율로 정제수에 용해시켜 비타민수용액을 제조하고 헛개열매와 인진쑥과 감초를 일정비율로 혼합하고 물추출하여 생약재추출액을 제조하여 비타민수용액과 혼합한 다음 혼합수용액을 전처리된 수삼에 침지처리하거나 도포하고 동결건조하여 수분제거에 따른 미세공극의 형성으로 혼합수용액의 유효성분이 수삼 내부로 침투되어 흡착됨으로써 완성된 동결건조인삼에 비타민 C와 비타민 B군 복합체 및 헛개열매와 인진쑥과 감초의 유효성분이 다량 함침되어 이를 취식시 인삼의 기본적인 효능과 더불어 체내 에너지대사의 활성화, 간기능보호, 항산화 효능, 피로회복 등의 효능을 지니게 된다.
As described above, according to the present invention, vitamin A and vitamin B complexes, which are water-soluble vitamins, are dissolved in purified water in a certain ratio to prepare vitamin aqueous solution, mixed with horticultural fruit, horse mugwort and licorice at a certain ratio, After mixing with an aqueous solution of vitamin A, the mixed aqueous solution is immersed or pretreated in the pretreated fresh ginseng and lyophilized to form micropores upon the removal of water, so that the active ingredient of the mixed aqueous solution penetrates into the ginseng and is adsorbed. And vitamin B complexes, and the active ingredients of hunting fruit, horse mugwort, and licorice are largely impregnated and have the basic efficacy of ginseng, the activation of energy metabolism in the body, protection of liver function, antioxidant efficacy and fatigue recovery.
도 1은 본 발명에 따른 비타민과 생약재성분이 함유된 동결건조인삼의 제조공정을 단계별로 나타낸 블록도BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a block diagram showing the steps of manufacturing freeze-dried ginseng containing vitamins and herbal medicine ingredients according to the present invention
본 발명은 체내 에너지대사의 활성화, 간기능보호, 항산화 효능, 피로회복 등에 뛰어난 효능을 지닌 수용성 비타민과 헛개열매, 인진쑥, 감초로 이루어진 생약재성분이 함침처리된 동결건조인삼 및 그 제조방법에 관한 것으로서, 수삼을 수세하고 선별하여 일정두께를 지닌 절편상태로 절단하거나 세근을 절단제거한 원형삼 형태의 수삼을 준비하는 전처리단계와, 수용성 비타민 C와 비타민 B군 복합체를 정제수에 일정비율로 용해시켜 비타민수용액을 제조하는 단계와, 헛개열매와 인진쑥과 감초를 일정비율로 혼합하고 물추출하여 생약재추출액을 제조하는 단계와, 비타민수용액과 생약재추출액을 일정비율로 혼합한 혼합수용액에 전처리된 수삼을 일정온도에서 일정시간 동안 침지시키거나 혼합수용액을 전처리된 수삼에 분사방식으로 일정량 도포하여 피막을 형성하는 혼합수용액처리단계와, 혼합수용액으로 처리된 수삼을 동결건조시켜 수분을 제거하면서 수분제거에 따른 미세공극의 형성으로 혼합수용액의 유효성분이 수삼 내부로 침투하여 흡착되도록 하는 동결건조단계로 구성된다.
The present invention relates to a freeze-dried ginseng impregnated with water-soluble vitamins, hornblende, artemisia, and licorice, which have excellent effects on activation of energy metabolism in the body, protection of liver function, antioxidative efficacy and fatigue recovery, A pretreatment step of preparing ginseng in the form of a round ginseng which is washed and cut with water and cut into slices having a predetermined thickness or cut hairless roots, and a step of dissolving the water-soluble vitamin C and the vitamin B group complex in purified water at a predetermined ratio, A step of preparing a herbal medicine extract by mixing water and a mixture of hovenous fruit, horse mugwort and licorice at a certain ratio; and a step of mixing the aqueous solution of the vitamin and the extract of the herbal medicine to prepare a mixed aqueous solution, For a period of time or by spraying the mixed aqueous solution onto the pre-treated ginseng in a predetermined amount A freeze-drying step of freezing and drying the raw ginseng treated with the mixed aqueous solution so that the active ingredient of the mixed aqueous solution penetrates into the ginseng and is adsorbed by formation of microvoids due to water removal while removing moisture; .
이하 본 발명에 따른 바람직한 구성을 각 단계별로 구체적으로 살펴보면 다음과 같다.
Hereinafter, preferred embodiments of the present invention will be described in detail.
1. 전처리단계1. Pre-processing step
수삼을 수세하고 선별하여 일정두께를 지닌 절편상태로 절단하거나 세근을 절단제거한 원형삼 형태의 수삼을 준비하는 단계로서, 수삼을 물로 수세하여 이물질을 제거하고 표면의 수분을 건조시킨 상태에서 일정크기로 선별된 수삼을 섬유질의 직각방향으로 5 ~ 10mm 두께의 절편상태로 절단하거나 또는 세근(細根) 절단제거한 원형삼 형태의 수삼을 준비하게 된다.
The step of preparing fresh-ginseng-shaped ginseng by cutting the fresh ginseng and cutting it into sliced pieces having a certain thickness or cutting off the fine roots. The ginseng is washed with water to remove foreign substances, and the surface moisture is dried The fresh ginseng is cut into slices of 5 to 10 mm thickness in the direction perpendicular to the fibers, or fresh ginseng in the form of round ginseng is prepared by cutting fine roots.
2. 비타민수용액을 제조하는 단계2. Step of preparing vitamin aqueous solution
수용성 비타민 C와 비타민 B군 복합체를 정제수에 일정비율로 용해시켜 비타민수용액을 제조하는 단계로서, 비타민 C와 비타민 B군 복합체는 수용성 비타민으로 물에 잘 녹기 때문에 과잉 섭취해도 몸에 축적되지 않으며, 이러한 수용성 비타민은 체내 에너지대사에 관여하여 성장이나 대사가 왕성한 조직, 피부, 혈액, 소화관, 신경계 등에 영향을 주고 부족하면 피부염이나 빈혈, 소화기능 저하, 신경장애 등을 일으키는 것으로, 본 발명에서는 전처리된 수삼에 수용성 비타민의 유효성분이 효과적으로 함침될 수 있도록 비타민수용액을 제조하되, 정제수 1000중량부에 대하여 비타민 C 10 ~ 20중량부와 비타민 B군 복합체 10 ~ 20중량부를 혼합 용해시켜 비타민수용액을 제조하게 된다.Soluble vitamin C and a vitamin B group complex are dissolved in purified water at a predetermined ratio to prepare an aqueous solution of vitamin. Since the vitamin C and vitamin B complexes are soluble in water and are well soluble in water, they are not accumulated in the body even when they are overdosed. Water-soluble vitamins are involved in energy metabolism in the body, and they affect tissues, skin, blood, digestive tract, nervous system and the like which are rich in growth or metabolism. When they are insufficient, they cause dermatitis and anemia, digestive dysfunction and neuropathy. In the present invention, The vitamin A solution is prepared by mixing 10-20 parts by weight of vitamin C and 10-20 parts by weight of the vitamin B group complex with 1000 parts by weight of purified water so that the active ingredient of the water-soluble vitamin can be effectively impregnated.
상기 비타민 C는 인체의 기능과 건강 유지를 위한 미량 원소 중의 하나로 아스코르빈산이라고도 불리우며 인체의 감염에 대한 저항성 및 철분의 흡수를 촉진시키고 상처를 치유하며 조직을 건강하게 유지할 수 있도록 돕고 항산화제 중의 하나로서 자유기(free radicals)에 의한 세포 손상을 방지하여 항산화 활성을 띠게 하며, 생체 내에서 여러 가지 효소반응의 조효소로 쓰이면서 피부, 골격, 혈관, 연골 등의 결합조직을 구성하는 주요 단백질인 콜라겐의 합성에 관여하는 것으로, 본 발명에서는 비타민 C를 정제수 1000중량부에 대하여 10 ~ 20중량부 혼합하여 용해시키도록 되어 있으며, 비타민 C가 10중량부 미만으로 혼합되면 항산화 등의 효능이 거의 발현되지 않으며 20중량부를 초과하여 혼합되면 특유의 신맛이 너무 강하여 동결건조인삼의 취식감이 크게 저하되는 문제점이 발생된다.
Vitamin C is one of the trace elements for maintaining the function and health of the human body. It is also called ascorbic acid. It promotes the resistance of the human body to infection and absorption of iron, heals wounds, helps to keep the tissue healthy, Which inhibits cell damage caused by free radicals and thus has antioxidant activity. It is used as a coenzyme of various enzymatic reactions in vivo, and is used as a main protein of collagen such as skin, skeleton, blood vessel, cartilage, In the present invention, 10 to 20 parts by weight of vitamin C is mixed and dissolved in 1000 parts by weight of purified water. When vitamin C is added in an amount of less than 10 parts by weight, antioxidative effects are hardly expressed And if it is mixed more than 20 parts by weight, the peculiar sour taste is too strong, There is a problem that the temperature is lowered.
상기 비타민 B군 복합체는 어느 하나만 결핍되어도 기본적 세포의 생리기능이 장애를 받게 되는 것으로, 본 발명에서는 비타민 B군 복합체로서 비타민 B1, B2, B3, B6, B12, 엽산이 일정비율로 혼합되어 사용되는데, 비타민 B군 복합체를 정제수 1000중량부에 대하여 10 ~ 20중량부 혼합하여 용해시키도록 되어 있으며, 비타민 B군 복합체가 10중량부 미만으로 혼합되면 체내 에너지대사 활성화 등의 효능이 거의 발현되지 않으며 20중량부를 초과하여 혼합되면 체내 과량 섭취로 인해 배출되는 문제점이 발생된다.
In the present invention, the vitamin B group complex is selected from the group consisting of vitamin B 1 , B 2 , B 3 , B 6 , B 12 , folic acid in a certain ratio The vitamin B group complex is mixed and dissolved in an amount of 10 to 20 parts by weight based on 1000 parts by weight of purified water. When the vitamin B group complex is mixed in an amount of less than 10 parts by weight, They are hardly expressed and when they are mixed in excess of 20 parts by weight, they are discharged due to excessive intake in the body.
상기 비타민 B1은 곡류와 육류를 비롯하여 콩류, 견과류, 생선류에 비교적 많이 들어 있고 탄수화물과 에너지 대사에 필요하며 결핍되면 각기가 나타나며 증상은 식욕부진, 전신쇠약, 불면증, 심한 피로, 부종 등이 나타나고 점차로 감각 및 운동장애가 나타나며, 본 발명에서 비타민 B1은 정제수 1000중량부에 대하여 3 ~ 4중량부 혼합하여 첨가하는 것이 바람직하다.
The vitamin B 1 is relatively present in cereals and meat as well as in beans, nuts and fishes, and is required for carbohydrate and energy metabolism. Each of these symptoms is manifested by anorexia, general weakness, insomnia, severe fatigue and edema, Sensory and motor disorders. In the present invention, vitamin B 1 is preferably added in an amount of 3 to 4 parts by weight based on 1000 parts by weight of purified water.
상기 비타민 B2는 체내에서의 에너지생성에 도움을 주며 여러가지 효소반응에 관여하는데, 특히 열량 대사에서 중요한 역할을 하며 다양한 종류의 리보플라빈 효소들이 탄수화물, 지방, 아미노산의 대사경로에서 탈수소화반응, 수산화반응, 산화탈탄산반응, 이산소화반응, 산소의 과산화수소로의 환원 반응 등에 필수적인 것으로, 본 발명에서 비타민 B2는 정제수 1000중량부에 대하여 2.6 ~ 3.8중량부 혼합하여 첨가하는 것이 바람직하다.
The vitamin B 2 plays an important role in energy metabolism and plays a role in various enzymatic reactions, especially in caloric metabolism. Various kinds of riboflavin enzymes catalyze dehydrogenation, hydroxylation reaction in the metabolic pathway of carbohydrate, fat, , Oxidative decarboxylation reaction, diazotization reaction, reduction reaction of oxygen to hydrogen peroxide, etc. In the present invention, it is preferable that vitamin B 2 is added by mixing 2.6 to 3.8 parts by weight with respect to 1000 parts by weight of purified water.
상기 비타민 B3는 체내 에너지대사 과정에서 조효소의 구성성분으로 작용하며 주요 공급원은 우유, 치즈, 계란, 간장, 육류 등으로 비타민 B2는 자외선을 조사되면 파괴되며 결핍되면 구각염, 설염, 지루성 피부염 등의 증상이 나타내는 것으로, 본 발명에서 비타민 B3는 정제수 1000중량부에 대하여 1.6 ~ 2.8중량부 혼합하여 첨가하는 것이 바람직하다.
The vitamin B 3 acts as a constituent of the coenzyme during energy metabolism in the body. The main sources of vitamin B 3 are milk, cheese, eggs, liver, meat, etc. Vitamin B 2 is destroyed when irradiated with ultraviolet light. . In the present invention, vitamin B 3 is preferably added in an amount of 1.6-2.8 parts by weight based on 1000 parts by weight of purified water.
상기 비타민 B6는 아미노전이효소, 탈탄산효소 및 입체이성질효소 등 100여 종의 아미노산 대사에 관여하는 효소의 조효소이며, 입체이성질효소로 D형 아미노산과 L형 아미노산의 상호전환에 작용하고 인체에서 단백질이 합성될 때에는 L형 아미노산만이 사용되므로 단백질 대사에도 관여하며, 호모시스테인의 이화작용 및 인산화효소 반응의 조효소로서도 작용하는 것으로, 본 발명에서 비타민 B6는 정제수 1000중량부에 대하여 2.2 ~ 3.4중량부 혼합하여 첨가하는 것이 바람직하다.
The vitamin B 6 is a coenzyme of an enzyme involved in the metabolism of about 100 kinds of amino acids such as aminotransferase, decarboxylase and stereoselective enzyme. It acts as a stereoisomeric enzyme for the conversion of D-amino acid and L-amino acid, Since only L-type amino acid is used when protein is synthesized, it also participates in protein metabolism, and acts as a coenzyme of homocysteine catabolism and phosphorylation enzyme reaction. In the present invention, vitamin B 6 is added in an amount of 2.2 to 3.4 weight It is preferable to add them by submixing.
상기 비타민 B12는 물질 대사에 참여하는 수용성 비타민으로, 엽산 조효소를 활성화하는데 관여하고 엽산은 비타민 B12 조효소를 활성화하는데 필요한 메틸기를 제공하고, 또한 비타민 B12는 신경섬유를 싸고 보호하는 수초를 정상적으로 유지하는데 관여하며 비타민 B12의 적절한 섭취는 정상적인 혈액 생산과 신경 작용에 필수적인 것으로, 본 발명에서 비타민 B12는 정제수 1000중량부에 대하여 1.6 ~ 2.8중량부 혼합하여 첨가하는 것이 바람직하다.
The vitamin B 12 is a water-soluble vitamin that participates in the metabolism and is involved in the activation of the folate coenzyme. The folic acid provides the methyl group necessary for activating the vitamin B 12 coenzyme, and the vitamin B 12 provides the normal And proper intake of vitamin B 12 is essential for normal blood production and nerve action. In the present invention, vitamin B 12 is preferably added in an amount of 1.6-2.8 parts by weight based on 1000 parts by weight of purified water.
상기 엽산은 비타민 B군 복합체의 하나로서, 세포 내에서 기본적인 조효소 형태인 테트라히드로폴산(tetrahydrofolic acid, THFA)으로 전환되며 핵산 대사에서 단일탄소 전이반응에 조효소 역할을 수행하고, DNA합성에 필요한 티미딜레이트(thymidylate)의 합성에 필수요소로 엽산의 결핍시 세포분열이 정상적으로 일어나기 어려우며, 히스티딘의 분해, 히스티딘 대사의 중간 대사물질인 포르미니노-글루탐산(forminino-glutamic acid)의 대사과정, 세린과 글리신의 상호전환, 메티오닌의 합성에 관여하며, 호모시스테인으로부터 합성된 메티오닌은 뇌에서 신경전달물질을 합성할 때 필요한 S-아데노실메티오닌으로 전환된 후 체내에 필요한 여러 대사과정에서 메틸기를 제공해 주는 물질로 작용하는 것으로, 본 발명에서 엽산은 정제수 1000중량부에 대하여 1.2 ~ 2.4중량부 혼합하여 첨가하는 것이 바람직하다.
The folic acid is one of the vitamin B group complexes which is converted into a basic coenzyme form tetrahydrofolic acid (THFA) in the cell and acts as a coenzyme in the single carbon transfer reaction in the nucleic acid metabolism, It is essential for the synthesis of thymidylate that cell division fails to occur normally when deficient in folic acid, and it is difficult to break down histidine, metabolism of forminino-glutamic acid, an intermediate metabolite of histidine metabolism, And the synthesis of methionine. Methionine synthesized from homocysteine is converted to S-adenosylmethionine, which is necessary for synthesis of neurotransmitter in the brain, and is a substance that provides methyl group in various metabolic processes required in the body. In the present invention, folic acid is contained in an amount of 1.2 to 2.4 parts by weight per 1000 parts by weight of purified water The combined, it is preferable to add.
3. 생약재추출액을 제조하는 단계3. Step of preparing the extract of the herbal medicine
헛개열매와 인진쑥과 감초를 일정비율로 혼합하고 물추출하여 생약재추출액을 제조하는 단계로서, 간기능보호 효능을 지는 헛개열매와 인진쑥과 감초를 일정비율로 혼합하고 정제수에 넣어 90 ~ 100℃에서 6 ~ 10시간 동안 끓이는 방식으로 물추출하여 생약재추출액을 제조하되, 본 발명에서는 전처리된 수삼에 생약재추출액의 유효성분이 효과적으로 함침될 수 있도록 정제수 1000중량부에 대하여 헛개열매 22 ~ 34 중량부와 인진쑥 26 ~ 38중량부와 감초 6 ~ 18중량부를 혼합하여 물추출하도록 되어 있다.
The step of preparing the extract of the herbal medicines by mixing the hinoki fruit, the horse mugwort and the licorice at a certain ratio, and mixing the hinoki fruit having the liver function protecting effect with the horse mugwort and the licorice at a certain ratio, The present invention provides a method for producing a herbal medicine extract which comprises adding 22 to 34 parts by weight of hunting fruit and 26 to 34 parts by weight of horse chestnut to 1000 parts by weight of purified water so that the effective ingredient of the herbal medicine extract solution can be effectively impregnated with pretreated fresh ginseng, 38 parts by weight and 6 to 18 parts by weight of licorice are mixed to extract water.
상기 헛개열매는 지구자로 불리우며 맛이 달다고 해서 나무에서 나는 꿀이라는 뜻으로 목밀(木蜜)이라고도 하며, 약간의 단맛과 쓴맛, 떫은 맛을 내며 열병으로 인한 번열, 구갈, 딸꾹질, 구토 등에 쓰이며 이뇨를 돕고, 알코올중독으로 상한 간장을 치료하는 등의 간기능보호에 큰 효능을 지니고 있는 것으로, 본 발명에서 헛개열매는 정제수 1000중량부에 대하여 22 ~ 34중량부 첨가혼합되며 헛개열매가 23중량부 미만으로 첨가되는 경우에는 간기능보호 등의 효과가 극미하며 32중량부를 초과하여 첨가되는 경우에는 쓴맛과 떫은 맛이 강해져 동결건조인삼의 취식감이 크게 저하되는 문제점이 발생된다.The fruit is called as the earth, and it is called "wood honey" because it is tasted by the taste. It is a bit sweet and bitter, has a bitter flavor and is used for fever, burning, hiccups and vomiting. And 22% by weight to 34% by weight with respect to 1000 parts by weight of purified water in the present invention. In the present invention, the hoven fruit is mixed with 23 parts by weight , The effect of protecting the liver function is extremely small. When added in an amount exceeding 32 parts by weight, bitterness and bitter taste are intensified, which causes a problem of deterioration of the feeling of freeze-dried ginseng.
상기 인진쑥은 간의 독성성분과 노폐물을 해독시키며 담즙분비 촉진, 간경화, 황달 등의 간질환을 완화시키고 혈류순환에 따른 동맥경화개선, 소화기능 개선 및 이뇨작용 촉진 등의 효능을 지닌 것으로, 본 발명에서 인진쑥은 정제수 1000중량부에 대하여 26 ~ 38중량부 첨가혼합되며 인진쑥이 26중량부 미만으로 첨가되는 경우에는 간의 독성성분 해독 등의 효과가 극미하며 38중량부를 초과하여 첨가되는 경우에는 과량섭취에 따른 복통, 부정맥, 저혈량성 쇼크 등의 부작용을 유발시키는 문제점이 발생된다.
The present invention relates to a pharmaceutical composition for preventing or treating liver diseases such as gallbladder, liver cirrhosis, and jaundice. 26 to 38 parts by weight of Angelica japonica is added in an amount of 26 to 38 parts by weight based on 1000 parts by weight of purified water. When the amount of Angelica japonica is less than 26 parts by weight, the effect of detoxifying the toxic components of the liver is extremely small. Abdominal pain, arrhythmia, hypovolemic shock, and the like.
상기 감초는 모든 약의 독성을 조화시켜서 약효가 잘 나타나게 하며 장부의 한열과 사기를 다스리고 모든 혈맥의 소통을 잘 시키며 근육과 뼈를 튼튼하게 하고, 약리작용은 해독작용, 간염, 두드러기, 피부염, 습진 등에 효과가 있으며, 진해, 거담, 근육이완, 이뇨작용, 항염작용 및 소화성궤양을 억제하는 효능을 지니고 있는 것으로, 본 발명에서 감초는 정제수 1000중량부에 대하여 6 ~ 18중량부 첨가혼합되며 감초가 6중량부 미만으로 첨가되는 경우에는 해독작용 등의 효과가 극미하며 18중량부를 초과하여 첨가되는 경우에는 단맛이 너무 강해져 동결건조인삼의 취식감이 크게 저하되는 문제점이 발생된다.
The licorice harmonizes the toxicity of all medicines and makes the medicinal effect appear. It regulates the fever and fragility of the book, makes good communication of all blood vessels, strengthens the muscles and bones, and pharmacological action is detoxification, hepatitis, urticaria, And has an effect of inhibiting the digestive juice, muscular relaxation, diuretic action, anti-inflammatory action and peptic ulcer. In the present invention, licorice is added in an amount of 6 to 18 parts by weight based on 1000 parts by weight of purified water, When added in an amount of less than 6 parts by weight, the effect of detoxification or the like is minimal, and when added in an amount exceeding 18 parts by weight, the sweetness becomes too strong, which causes a problem in that the feeling of freeze-
4. 혼합수용액처리단계4. Mixed aqueous solution treatment step
이전 단계에서 제조된 비타민수용액과 생약재추출액을 일정비율로 혼합한 혼합수용액에 전처리된 수삼을 25 ~ 55℃의 온도에서 40 ~ 60시간 동안 침지시키거나 혼합수용액을 전처리된 수삼에 분사방식으로 일정량 도포하여 피막을 형성하는 단계로서, 본 발명에서는 전처리된 수삼에 침지용으로 사용되는 혼합수용액은 비타민수용액 65 ~ 85중량%와 생약재추출액 15 ~ 35중량%를 혼합하여 침지용 혼합수용액으로 사용하며, 전처리된 수삼에 분사용으로 사용되는 혼합수용액은 비타민수용액 60 ~ 80중량%와 생약재추출액 20 ~ 40중량%를 혼합하여 분사용 혼합수용액으로 사용하는데, 침지용 혼합수용액에서 비타민수용액을 85중량% 초과하여 첨가하거나 분사용 혼합수용액에서 비타민수용액을 80중량% 초과하여 첨가하는 경우에는 신맛이 너무 강해져 취식감이 저하되는 문제점이 발생되고, 침지용 혼합수용액에서 생약재추출액을 35중량% 초과하여 첨가하거나 분사용 혼합수용액에서 비타민수용액을 40중량% 초과하여 첨가하는 경우에는 동결건조인삼의 색상이 너무 검게 나타나고 생약재 특유의 맛이 강해져 상품성이 크게 저하되는 문제점이 발생된다.
Prepared ginseng is immersed in a mixed aqueous solution prepared by mixing the aqueous vitamin solution and the herbal medicine extract prepared in the previous step at a temperature of 25 to 55 ° C for 40 to 60 hours or a predetermined amount of the aqueous solution is applied to the pretreated ginseng In the present invention, in the present invention, the mixed aqueous solution used for dipping in the preprocessed ginseng is prepared by mixing 65 to 85% by weight of an aqueous solution of vitamin and 15 to 35% by weight of an extract of a herbal medicine, The mixed aqueous solution used for the raw ginseng is mixed with 60 to 80% by weight of an aqueous solution of vitamin A and 20 to 40% by weight of an extract of a herbal medicinal material. The mixed aqueous solution contains more than 85% by weight of an aqueous solution of vitamin When the aqueous solution of vitamin A is added in an amount of more than 80% by weight in the aqueous solution to be added or mixed for use, the sour taste becomes too strong, When the addition of more than 35% by weight of the herbal medicine extract solution in the mixed aqueous solution for immersion or the addition of the aqueous vitamin solution in an amount exceeding 40% by weight in the mixed aqueous solution for solution preparation is too dark, the color of the lyophilized ginseng becomes too black, The taste of the beverage is intensified and the merchantability is greatly deteriorated.
또한, 상기 침지용 혼합수용액보다 분사용 혼합수용액이 생약재추출액의 혼합량이 더 높게 첨가되는 이유는 일반적으로 비타민수용액의 흡착성과 흡수율이 생약재추출액보다 높게 나타나 분사용 혼합수용액의 경우 도포과정에서 생약재추출액의 흡착성과 흡수율을 높이기 위해 생약재추출액의 혼합비율을 침지용 혼합수용액보다 좀더 높게 하는 것이 바람직하다.
In addition, the reason why the mixing amount of the aqueous solution for medicinal purposes is higher than that of the mixed aqueous solution for dipping is that the adsorption and absorption rate of the aqueous solution of vitamin are generally higher than those of the medicinal herb extract, It is preferable to increase the mixing ratio of the crude drug extract solution to be higher than that of the mixed aqueous solution for dipping in order to increase the adsorption property and the water absorption rate.
본 발명에서의 구체적인 침지조건은 전처리된 수삼 20중량부에 대하여 침지용 혼합수용액 90 ~ 110중량부를 가하여 25 ~ 55℃의 온도로 40 ~ 60시간 동안 침지시켜 혼합수용액의 유효성분이 수삼에 함침되도록 한다.
In the present invention, 90 to 110 parts by weight of a mixed aqueous solution for immersion is added to 20 parts by weight of pretreated ginseng, and the mixture is immersed at 25 to 55 ° C for 40 to 60 hours so that the active ingredient of the mixed aqueous solution is impregnated with fresh ginseng .
또한, 본 발명에서의 구체적인 분사조건은 전처리된 수삼 100중량부에 대하여 혼합수용액 15 ~ 25중량부를 통상의 분무장치로 분사하여 표면에 고르게 도포되도록 한다.
In the present invention, 15 to 25 parts by weight of the mixed aqueous solution is sprayed by a conventional spraying device on 100 parts by weight of the preprocessed ginseng to uniformly spread on the surface.
5. 동결건조단계5. Freeze-drying step
혼합수용액으로 처리된 수삼을 동결건조시켜 수분함량이 5중량% 이하가 되도록 수분을 제거하면서 수분제거에 따른 미세공극의 형성으로 혼합수용액의 유효성분이 수삼 내부로 침투하여 흡착되도록 하는 단계로서, -35 ~ -45℃의 온도로 유지되는 냉동응축기 내부에 혼합수용액으로 처리된 수삼을 넣은 후 -18 ~ -24℃ 정도가 될 때까지 수분을 동결시키고 동결된 수삼을 진공압력이 1 ~ 3mmHg인 진공관체에서 16 ~ 20시간 동안 승화, 건조시켜 수분함량 5중량% 이하의 동결건조인삼을 제조하게 된다.
Freeze-dried ginseng treated with the mixed aqueous solution to remove water to make the water content equal to or less than 5% by weight so that the active ingredient of the mixed aqueous solution penetrates into the ginseng by adsorption of micro-pores upon removal of water, The fresh ginseng treated with the mixed aqueous solution was put into a freezing condenser maintained at a temperature of -45 캜. The water was frozen until the temperature became -18 ~ -24 캜, and the frozen ginseng was put in a vacuum tube having a vacuum pressure of 1 ~ For 16 to 20 hours to prepare lyophilized ginseng having a moisture content of 5% by weight or less.
또한, 혼합수용액으로 처리된 수삼을 동결건조하는 과정에서 수삼 내부의 수분이 제거되어 그 내부에 무수한 미세공극이 형성되고 수삼의 표피 부분에 함침되거나 도포되어 있는 비타민성분과 생약재성분이 수삼 내부의 미세공극으로 침투하여 흡착되면서 건조처리되어 완성된 동결건조인삼의 내부에도 비타민과 생약재의 유효성분이 다량 함유되어 취식시 인삼의 기본적인 효능과 더불어 비타민C, B군 복합체와 헛개열매, 인진쑥, 감초의 체내 에너지대사의 활성화, 간기능보호, 항산화 효능, 피로회복 등의 효능을 발휘하게 된다.
In addition, in the process of freeze-drying the ginseng treated with the mixed aqueous solution, the water inside the ginseng is removed, innumerable micropores are formed therein, and the vitamin component and the herbal medicine ingredient impregnated or coated on the surface portion of the ginseng, The freeze-dried ginseng contains a large amount of vitamins and herbal medicines as well as the basic effects of ginseng. It also contains vitamins C and B complexes, hoven fruit, Metabolism, liver function protection, antioxidant efficacy, and fatigue recovery.
상기와 같이 완성된 동결건조인삼은 통상의 플라스틱 밀폐용기에 넣어 진공포장하거나 질소충진 포장 등을 통해 완제품으로 판매된다.
The lyophilized ginseng thus prepared is put into a conventional plastic sealed container and is then sold as an article through vacuum packing or nitrogen filling packing.
이하 본 발명에 따른 바람직한 실시예는 다음과 같다.
Hereinafter, preferred embodiments according to the present invention will be described.
< 실시예 1 >≪ Example 1 >
선별 수세된 수삼을 7mm 두께를 지닌 절편상태로 절단하고, 정제수 1000ml에 비타민 C 16g과 비타민 B1 3.5g, 비타민 B2 3.2g, 비타민 B3 2.2g, 비타민 B6 2.8g, 비타민 B12 2.2g, 엽산 1.8g을 용해시켜 비타민수용액을 제조하며, 정제수 1000ml에 헛개열매 28g, 인진쑥 32g, 감초 12g을 넣고 90℃에서 8시간 물추출하여 생약재추출액을 제조한 다음 비타민수용액 75중량%와 생약재추출액 25중량%를 혼합하여 혼합수용액을 제조하고 상기 혼합수용액 100ℓ에 절단된 수삼 20kg을 넣어 40 ℃의 온도에서 48시간동안 침지처리하며, 혼합수용액으로 침지처리된 수삼을 동결건조시켜 수분함량 5중량%의 동결건조인삼을 제조하였다.
Cutting the selected washing ginseng to intercept condition with a 7mm thick and vitamin C and vitamin 16g in 1000ml of purified water 3.5g B 1, vitamin B 2 3.2g, 2.2g Vitamin B 3, Vitamin B 6 2.8g vitamin B 12 2.2 g and folic acid 1.8 g were dissolved to prepare an aqueous vitamin solution. Water extracts of 28 g of hoven fruit, 32 g of persimmon powder and 12 g of licorice were added to 1000 ml of purified water and the mixture was extracted with water at 90 ° C for 8 hours to prepare a herbal extract. And 20 wt% of fresh ginseng cut into 100 L of the mixed aqueous solution was immersed for 48 hours at a temperature of 40 DEG C. The ginseng thus immersed in the mixed aqueous solution was lyophilized to obtain a water content of 5 wt% Freeze dried ginseng was prepared.
< 실시예 2 >≪ Example 2 >
선별 수세된 수삼을 7mm 두께를 지닌 절편상태로 절단하고, 정제수 1000ml에 비타민 C 16g과 비타민 B1 3.5g, 비타민 B2 3.2g, 비타민 B3 2.2g, 비타민 B6 2.8g, 비타민 B12 2.2g, 엽산 1.8g을 용해시켜 비타민수용액을 제조하며, 정제수 1000ml에 헛개열매 28g, 인진쑥 32g, 감초 12g을 넣고 90℃에서 8시간 물추출하여 생약재추출액을 제조한 다음 비타민수용액 70중량%와 생약재추출액 30중량%를 혼합하여 혼합수용액을 제조하고 절단된 수삼 100g 당 상기 혼합수용액 20ml를 통상의 분무장치를 통해 표면에 도포처리하며, 혼합수용액으로 도포처리된 수삼을 동결건조시켜 수분함량 5중량%의 동결건조인삼을 제조하였다.
Cutting the selected washing ginseng to intercept condition with a 7mm thick and vitamin C and vitamin 16g in 1000ml of purified water 3.5g B 1, vitamin B 2 3.2g, 2.2g Vitamin B 3, Vitamin B 6 2.8g vitamin B 12 2.2 g and folic acid 1.8 g were dissolved to prepare an aqueous vitamin solution. To the extract of the herbal medicines was added a solution of 28 g of hoven fruit, 32 g of persimmon powder and 12 g of licorice in 1000 ml of purified water, and extracted with water at 90 ° C for 8 hours. 30% by weight of water was mixed to prepare a mixed aqueous solution. 20 ml of the mixed aqueous solution was applied to the surface of 100 g of the cut ginseng by a conventional spraying device, and the ginseng coated with the mixed aqueous solution was lyophilized to obtain a water- Freeze dried ginseng was prepared.
< 비교예 1 >≪ Comparative Example 1 &
선별 수세된 수삼을 7mm 두께를 지닌 절편상태로 절단하고, 절단된 수삼을 수용성 비타민과 생약재추출액을 처리하지 않은 상태로 동결건조시켜 수분함량 5중량%의 동결건조인삼을 제조하였다.
The washed ginseng was cut into slices having a thickness of 7 mm, and the cut ginseng was freeze-dried without treating the water-soluble vitamins and herbal extracts to prepare 5% by weight of freeze-dried ginseng.
< 관능평가 ><Sensory Evaluation>
상기 실시예 1, 2의 동결건조인삼과 비교예 1의 동결건조인삼을 이용하여 관능평가를 실시하였다.
The sensory evaluation was performed using the lyophilized ginsengs of Examples 1 and 2 and the lyophilized ginseng of Comparative Example 1.
10 ~ 60대 남녀 각 5명씩 총 60명의 평가대상자를 선정하고, 씹는 질감(조직감), 맛, 향, 전체적인 취식감에 관하여 평점을 1점(매우 나쁘다) ~ 10점(매우 좋다) 사이에서 평가하도록 하는 10점 평점법을 사용하여 5회씩 관능평가하고 각 나이대별 관능평가의 평균값을 < 표 1 > 에 나타내었다.
A total of 60 people were selected for each of the 5 male and 5 female students aged 10 to 60 and the rating was evaluated between 1 point (very bad) and 10 points (very good) regarding the texture of chewing (texture), taste, The sensory evaluation was performed five times using the 10-point rating method, and the average value of the sensory evaluation by each age group is shown in Table 1.
평가항목
Evaluation items
구분
division
By age
Teenager
씹는 질감
(조직감)
Chewing texture
(Texture)
Example 1
Example 2
Comparative Example 1
맛
flavor
Example 1
Example 2
Comparative Example 1
6.8
향
incense
7.6
Example 2
Comparative Example 1
전체적인
취식감
Overall
Crust texture
8.0
Example 2
Comparative Example 1
상기 <표 1>에서와 같이 실시예 1의 동결건조인삼은 혼합수용액에 수삼을 일정시간 침지처리함에 따라 실시예 2와 비교예1의 동결건조인삼보다 조금 더 부드럽게 씹히는 질감이 느껴져 씹는 질감(조직감)이 평균 7.4로 실시예 2와 비교예1 보다 높은 수치를 나타내었고 맛과 향에 있어서는 감초의 단맛과 비타민 C 특유의 새콤하고 상큼한 맛과 향이 어우러지면서 인삼 특유의 쓴맛을 감소시켜 인삼에 대한 거부감이 크게 감소하여 전체적인 취식감이 평균 8.0의 높은 수치를 나타내었으며, 실시예 2의 동결건조인삼은 혼합수용액을 수삼에 분사처리하여 도포함에 따라 인삼 특유의 섬유질이 씹히는 질감이 그대로 느껴져 비교예1의 동결건조인삼과 동일, 유사하게 씹는 질감(조직감)이 평균 6.8을 나타내었으나 맛과 향에 있어서는 감초의 단맛과 비타민 C 특유의 새콤하고 상큼한 맛과 향이 어우러지면서 인삼 특유의 쓴맛을 감소시켜 인삼에 대한 거부감이 크게 감소하여 전체적인 취식감이 평균 7.8의 높은 수치를 나타내었으며, 비교예 1의 동결건조인삼은 인삼 특유의 쓴맛과 향이 그대로 느껴져 이에 따른 거부감으로 전체적인 취식감이 평균 6.7로 낮은 수치를 나타내었다.
As shown in Table 1, the lyophilized ginseng of Example 1 was slightly softer than the lyophilized ginseng of Example 2 and Comparative Example 1 by immersing the ginseng in the mixed aqueous solution for a certain period of time. As a result, the chewing texture ) Was 7.4, which was higher than those of Example 2 and Comparative Example 1. In terms of taste and aroma, the sweetness of licorice and the sweet and sour flavor and flavor unique to vitamin C were combined to reduce the bitter taste unique to ginseng, The ginseng-specific fiber texture of the freeze-dried ginseng of Example 2 was similar to that of the ginseng-treated ginseng according to Comparative Example 1 The average chewing texture (texture) of the freeze dried ginseng was 6.8, but the sweetness and vitamin C The sweetness and flavor of the ginseng were mixed to reduce the bitter taste of the ginseng. As a result, the feeling of rejection of the ginseng was greatly reduced, and the overall sensation of taste was 7.8 as high as in the comparative example 1. The ginseng freeze- The smell was felt as it was, and as a result, the overall sensation of feeling was lowered to an average of 6.7.
Claims (10)
A pretreatment step of preparing raw ginseng in the form of a round ginseng which is washed and cut with water and cut into slices having a predetermined thickness or cut hairy roots and preparing a vitamin aqueous solution by dissolving the water soluble vitamin C and vitamin B complexes in a certain ratio in purified water A step of mixing an aqueous solution of vitamin A and an extract of a herb medicine with a certain amount of water to prepare a mixed aqueous solution, which is prepared by mixing raw ginseng at 25 to 55 ° C At a temperature of 40 to 60 hours; and a step of lyophilizing the ginseng treated with the mixed aqueous solution to remove moisture such that the moisture content is 5% by weight or less, Wherein the active ingredient is permeated into the ginseng and adsorbed thereon. Freeze-dried ginseng containing vitamins and herbal ingredients.
A pretreatment step of preparing raw ginseng in the form of a round ginseng which is washed and cut with water and cut into slices having a predetermined thickness or cut hairy roots and preparing a vitamin aqueous solution by dissolving the water soluble vitamin C and vitamin B complexes in a certain ratio in purified water A step of preparing a herbal medicine extract by mixing the hull fruit with Artemisia capillaris and licorice at a certain ratio and water extraction to prepare a mixed aqueous solution of a mixed aqueous solution of the vitamin aqueous solution and the herbal medicine extract in a predetermined amount by spraying the pretreated fresh ginseng A step of lyophilizing the ginseng treated with the mixed aqueous solution to form a microporous layer by removing water while removing moisture to a water content of 5 wt% And then is adsorbed on the surface of the substrate Freeze-dried ginseng containing vitamins and herbal ingredients.
The vitamin solution according to claim 1 or 2, wherein the vitamin aqueous solution is prepared by mixing and dissolving 10 to 20 parts by weight of vitamin C and 10 to 20 parts by weight of a vitamin B group complex in 1000 parts by weight of purified water. Freeze dried ginseng containing ingredients.
4. The method of claim 3 wherein the vitamin B complex vitamins B 1 3 ~ 4 parts by weight of vitamin B 2 2.6 ~ 3.8 parts by weight of the vitamin B 3 1.6 ~ 2.8 parts by weight of vitamin B 6 2.2 ~ 3.4 wt. unit, and a vitamin B 12 1.6 ~ 2.8 parts by weight of a vitamin and saengyakjae freeze-dried ginseng the components are contained, characterized in that parts consisting of folic acid, 1.2 ~ 2.4 wt.
The method according to claim 1 or 2, wherein the herbal medicine extract solution is prepared by mixing 22 to 34 parts by weight of hornblende, 26 to 38 parts by weight of horse chestnut, 6 to 18 parts by weight of licorice with 1000 parts by weight of purified water, Freeze dried ginseng containing vitamins and herbal medicine components, which is prepared by boiling water for 10 hours.
The freeze-dried ginseng according to claim 1, wherein the mixed aqueous solution is prepared by mixing 65 to 85% by weight of an aqueous vitamin solution and 15 to 35% by weight of an extract of a herbal medicine extract.
The freeze-dried ginseng according to claim 2, wherein the mixed aqueous solution is prepared by mixing 60 to 80% by weight of an aqueous vitamin solution and 20 to 40% by weight of an extract of a herbal medicine extract.
Treating the raw ginseng with water and selecting it to prepare a raw ginseng-shaped ginseng which is cut into a section having a thickness of 5 to 10 mm or cut off fine roots, and a preparation step of adding 10 to 20 parts by weight of vitamin C and a vitamin B group complex 22 to 34 parts by weight of hoven fruit, 26 to 38 parts by weight of rhizome and 6 to 18 parts by weight of licorice are mixed with 1000 parts by weight of purified water to prepare a vitamin aqueous solution by mixing 10 to 20 parts by weight, Preparing an extract of the herbal medicine by extracting water by boiling for 6 to 10 hours, mixing the aqueous solution of the mixture of 65 to 85% by weight of the vitamin aqueous solution and 15 to 35% by weight of the extract of the herbal medicine with the 20% 110 to 55 parts by weight of water, and immersing the mixture at a temperature of 25 to 55 DEG C for 40 to 60 hours; and a step of lyophilizing the ginseng treated with the mixed aqueous solution to make the water content 5 wt% Wherein the active ingredient of the mixed aqueous solution penetrates into the ginseng and is adsorbed by the formation of micro pores due to the removal of water while removing the moisture so that the active ingredient of the ginseng is adsorbed. Way.
Treating the raw ginseng with water and selecting it to prepare a raw ginseng-shaped ginseng which is cut into a section having a thickness of 5 to 10 mm or cut off fine roots, and a preparation step of adding 10 to 20 parts by weight of vitamin C and a vitamin B group complex 22 to 34 parts by weight of hoven fruit, 26 to 38 parts by weight of rhizome and 6 to 18 parts by weight of licorice are mixed with 1000 parts by weight of purified water to prepare a vitamin aqueous solution by mixing 10 to 20 parts by weight, Preparing an extract of the herbal medicine by extracting water by boiling for 6 to 10 hours; mixing the aqueous mixture solution containing 15 to 80% by weight of vitamin A aqueous solution and 20 to 40% And 25 parts by weight of water are sprayed to form a film, and a step of lyophilizing the ginseng treated with the mixed aqueous solution to prepare a water content of not more than 5% by weight Wherein the active ingredient of the mixed aqueous solution penetrates into the ginseng and is adsorbed by the formation of microvoids due to the removal of water during the removal of the ginseng, thereby producing a freeze-dried ginseng containing vitamins and herbal medicines.
The method of claim 8 or claim 9 wherein the vitamin B complex vitamins B 1 3 ~ 4 parts by weight of vitamin B 2 2.6 ~ 3.8 parts by weight of the vitamin B 3 is and 1.6 ~ 2.8 parts by weight of vitamin B 6 2.2 to 3.4 parts by weight of vitamin B 12, 1.6 to 2.8 parts by weight of vitamin B 12 , and 1.2 to 2.4 parts by weight of folic acid.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106343416A (en) * | 2016-08-26 | 2017-01-25 | 兴化市东奥食品有限公司 | Method for producing dehydrated chive |
| KR20180025178A (en) * | 2016-08-30 | 2018-03-08 | 웰너스코리아 주식회사 | Method for manufacturing the porous Red Ginseng |
| KR101888145B1 (en) * | 2017-10-24 | 2018-08-14 | 주식회사 자로 | Freeze-drying ginseng with crispy taste and method thereof |
| KR101986506B1 (en) * | 2018-01-25 | 2019-06-10 | 크로텍바이오 주식회사 | Red ginseng with crispy taste and method thereof |
| KR20200095196A (en) * | 2019-01-31 | 2020-08-10 | 한남대학교 산학협력단 | Method for manufacturing of freeze-drying ginseng with chlorella containing selenium |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100998267B1 (en) | 2010-07-06 | 2010-12-03 | (재)남해마늘연구소 | Manufacturing method of garlic snack |
| KR101131837B1 (en) | 2012-02-24 | 2012-03-30 | 한국인삼농업법인(주) | Method for producing fermented black-red ginseng and fermented black-red ginseng produced by the same method |
-
2015
- 2015-04-14 KR KR1020150052385A patent/KR101619410B1/en active IP Right Grant
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100998267B1 (en) | 2010-07-06 | 2010-12-03 | (재)남해마늘연구소 | Manufacturing method of garlic snack |
| KR101131837B1 (en) | 2012-02-24 | 2012-03-30 | 한국인삼농업법인(주) | Method for producing fermented black-red ginseng and fermented black-red ginseng produced by the same method |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106343416A (en) * | 2016-08-26 | 2017-01-25 | 兴化市东奥食品有限公司 | Method for producing dehydrated chive |
| KR20180025178A (en) * | 2016-08-30 | 2018-03-08 | 웰너스코리아 주식회사 | Method for manufacturing the porous Red Ginseng |
| KR102096949B1 (en) | 2016-08-30 | 2020-04-03 | 웰너스코리아 주식회사 | Method for manufacturing the porous Red Ginseng |
| US11452307B2 (en) | 2016-08-30 | 2022-09-27 | Wellness Korea Co., Ltd. | Method for preparing porous red ginseng |
| KR101888145B1 (en) * | 2017-10-24 | 2018-08-14 | 주식회사 자로 | Freeze-drying ginseng with crispy taste and method thereof |
| KR101986506B1 (en) * | 2018-01-25 | 2019-06-10 | 크로텍바이오 주식회사 | Red ginseng with crispy taste and method thereof |
| KR20200095196A (en) * | 2019-01-31 | 2020-08-10 | 한남대학교 산학협력단 | Method for manufacturing of freeze-drying ginseng with chlorella containing selenium |
| KR102217235B1 (en) * | 2019-01-31 | 2021-02-19 | 한남대학교 산학협력단 | Method for manufacturing of freeze-drying ginseng with chlorella containing selenium |
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