KR101611134B1

KR101611134B1 - Method for preparing of cosmetic composition for regenerating skin

Info

Publication number: KR101611134B1
Application number: KR1020150085273A
Authority: KR
Inventors: 하승완
Original assignee: 하승완
Priority date: 2015-06-16
Filing date: 2015-06-16
Publication date: 2016-04-08

Abstract

The present invention relates to cosmetics for regenerating skin and a manufacturing method thereof and, more specifically, to cosmetics for regenerating skin, containing an epithelial cell growth factor, and increasing a skin regeneration effect by improving a unique function of epithelial cell growth factor protein by stabilizing the epithelial cell growth factor protein not to be denatured, and minimizing contents of a plant extract. The present invention also relates to a manufacturing method thereof.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a cosmetic preparation for skin regeneration,

The present invention relates to a method for producing cosmetics for skin regeneration, and more particularly, to cosmetics containing epidermal growth factor, which stabilizes the epithelial growth factor protein so as not to be denatured and minimizes the content of the plant extract, The present invention relates to a method for producing cosmetics for skin regeneration, which enhances the skin regeneration effect by improving the function inherent to the epithelial cell growth factor protein.

Generally, as age gets older, the regenerative power of the skin cells declines, the ability to maintain moisture decreases, and the collagen production slows down, resulting in wrinkles and spots on the face, reduced elasticity, and delayed wound healing. .

For this purpose, we make efforts to prevent aging of the skin through various exercises such as taking proper exercise and adequate sleeping, eating foods containing vitamins, minerals, antioxidants, etc. or applying moisturizing and elastic cosmetics to the skin have.

In recent years, cosmetics for regenerating skin cells themselves have been developed not only for skin cosmetics but also for a variety of cosmetics such as epidermal growth factor (EGF) (FGF), insulin-like growth factor (IGF), and the like have been increasingly attracted to cosmetics or medicines containing substances promoting skin regeneration.

Among them, epithelial growth factor is a protein called rh-Oligopeptide-1, which is a kind of protein that binds to receptors on the skin surface and promotes the production of new cells. These epithelial growth factors By stimulating cells that have undergone functioning due to skin aging, they stimulate cell division to help metabolism. By restoring the function of cells to change diseased or aged cells into healthy cells, they prevent wrinkles and relieve skin wrinkles And plays a role of regenerating the burned skin.

These epithelial growth factor proteins are autonomously supplied to the skin to restore damaged skin tissues while they are present in the human body. Since the production of the skin in the human body is reduced by the aging of the skin starting from the late 20s, Therefore, various studies for replacing the epithelial growth factor have been made.

However, the epithelial growth factor protein is disadvantageous in that its function is lost due to denaturation due to factors such as temperature and pH, and it is impossible to recover to its original state after such denaturation occurs.

Accordingly, the present inventors have studied the method of the present invention in order to complement the disadvantages of the epithelial growth factor protein and to respond to consumers' interest in cosmetics containing epithelial growth factor protein.

Korean Patent Laid-Open Publication No. 2015-30150 entitled " Method and Apparatus for Manufacturing Cosmetics for Regenerating Skin Cells "(Mar. 19, 201) Korean Patent Registration No. 1355385, "Peptides for skin regeneration, a cosmetic composition containing the same, and a skin regeneration method using the same" (2014.01.20) "Peptides having activity of epithelial growth factor and use thereof" of Korean Patent Registration No. 824396 (2008.04.16) "Functional cosmetic composition for skin regeneration" of Korean Patent Registration No. 1151397 (2012.05.23)

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a cosmetic composition containing epithelial growth factor protein, which minimizes the compounding process and the ingredients to prevent denaturation of the epithelial growth factor protein, And a method for producing the same.

In order to achieve the above-mentioned object, the skin regenerating cosmetic product according to the present invention comprises 99.00% by weight of Alcholic oligopeptide-1; 0.25-0. 35% by weight of tocopheryl acetate; 0.15-0.25 wt% allantoin; 0.15-0.25 wt% carbomer; 0.20% by weight of arginine; 0.025 to 0.075% by weight of zirconium; And 0.05% by weight of damask rose flower oil.

Here, the above-mentioned Alzheimer's peptide-1 is treated with liposome.

The method of manufacturing cosmetics for skin regeneration according to the present invention may further comprise the steps of: (a) sterilizing the compounding device at a temperature of 180 to 200 ° C during sterilization by dry heat and at 126 to 130 ° C during sterilization by high pressure steam; (B) injecting Alzheimer's peptide-1 into the compounding device after liposome treatment; Adding allantoin to the compounding device, slowly adding carbomer thereto, stirring the mixture at a temperature of 25 to 27 ° C at 49 to 50 rpm, Dispersing and dissolving osmotic rosemary oil, olivanium and tocopheryl acetate in a mixing device, stirring the mixture at a temperature of 25 to 27 ° C at 49 to 50 rpm; Mixing alginoligopeptide-1 and arginine with each other, mixing the mixture at a temperature of 25 to 27 ° C at 49 to 50 rpm, And (c) filtering and separating the mixture blended in the step (a).

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In addition, in the course of mixing the above-mentioned Alzheimer's peptide-1 and arginine, they are dispersed and mixed at a ratio of 5: 1 by weight.

INDUSTRIAL APPLICABILITY As described above, according to the cosmetic for skin regeneration and the method for producing the same of the present invention, in the production of a cosmetic product containing the epithelial growth factor protein, the mixing process is simplified and the ingredients are minimized, Skin whitening and the like, as well as to stabilize the epithelial cell growth factor protein so as not to be denatured, thereby improving the quality and ultimately increasing the skin regeneration effect, and a process for producing the same will be.

1 is a process diagram showing a process for producing a cosmetic for skin regeneration according to the present invention

Hereinafter, preferred embodiments of the present invention will be described in detail so that those skilled in the art can easily carry out the technical idea of the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

The cosmetic for skin regeneration according to the present invention contains 99.00% by weight of Alcholic oligopeptide-1, 0.25 to 0.35% by weight of tocopheryl acetate as an antioxidant, 0.15 to 0.25% by weight of allantoin as a skin protection agent, 0.15 to 0.25% %, 0.20% by weight of arginine as a pH controlling agent, 0.025% to 0.075% by weight of olivanium as a natural flavor and 0.05% by weight of damask rose oil.

This will be described in detail.

The rh-Oligopeptide-1 is composed of 53 amino acids and binds to the receptor protein on the skin surface to promote new cell formation and induce skin activation. It is preferable to appropriately blend the content of the natural plant extract to be described later.

In addition, the above-mentioned Alzheimer's peptide-1 has a concentration of 1 ppm and a purity of 96 to 97%, and is made of nanocapsules by liposome treatment. As a result, the raw material passes through the skin cells to reach the effective ingredient of the raw material to the dermal layer, It also combines a stimulation relaxation function.

Tocopheryl Acetate is a vegetable vitamin E derivative produced by the esterification of tocopheryl and acetic acid which is added to prevent oxidation of the skin, It is possible to prevent damage of the generated skin and enhance the skin moisturization.

Allantoin is a water-soluble, natural ingredient extracted from a comfrey root or sugar beet and is in the form of a white powder. It is added for skin protection and skin cell activation, thus improving skin turnover and calming skin .

When the allantoin is added in a large amount, it is preferable that 0.20% by weight is used because the powder may sink.

Carbomer is a water-soluble viscosity enhancer which is in the form of a white powder and is synthesized from acrylic acid. It is added to increase the viscosity and concentration of the raw material to keep the form stably, and has a moisturizing and protecting effect on the skin.

Arginine is a molecular formula C ₆ H ₁₄ N ₄ O ₂ and is in the form of a white powder. It is a natural amino acid synthesized in the human body and added to control the pH. And stability can be improved.

Olivanum is a pale yellow translucent oil extracted from oriental trunks. It has a fragrant lemon fragrance and is not only strong but also long-lasting. It is added for smell. Olibanum regulates sebaceous secretion and cell regeneration. It stimulates aged skin, promotes wound healing, and acts as a natural preservative, reducing skin irritation and enhancing stability compared to chemical preservatives.

Rosa Damascena Flower Oil (Rosa Damascena Flower Oil) is a volatile oil extracted from a damask rose flower. It is added to impart fragrance. Like olivanium, it is extracted from natural, So that it is possible to provide a fresh and refreshing feeling.

Thus, in the present invention, a plant extract such as daffodil rose oil or olivanum is blended to use the active ingredient contained in the natural plant, with the main ingredient of Alzheimer's peptide-1. In this case, 1 is decomposed by the activation of an enzyme such as protease, thereby preventing the loss of function of the oligopeptide-1.

Next, a method of manufacturing a cosmetic product effective for skin regeneration using raw materials having the above-described constitution will be described.

First, the present invention is to control the process conditions such as the blending ratio of each raw material and the compounding temperature so that the characteristics of the sub-raw materials are saved without hindering the function of the raw materials.

The method for producing a cosmetic for skin regeneration according to the present invention comprises the steps of: treating liposome of Al-Olehyde Peptide-1 as a main raw material; Agitating and mixing allantoin and carbomer in the liposome-treated aliquot of oligohyper peptide-1; Mixing and dispersing the multi-mask rose flower oil, the ovalbumin and the tocopheryl acetate in the formulation after the dispersion and dissolution; Mixing and dissolving Al-cholypeptide-1 and arginine in the formulation after dispersion-melting; And filtering and floating the combined mixture.

This will be described in detail as follows.

[1] Liposome treatment

The main ingredient, Alzheimer's peptide-1, is liposome-treated so that its effective ingredient penetrates effectively into the skin. At this time, lecithin, which is a natural emulsification component, is used for the liposome treatment of the above-mentioned Alzheimer's peptide-1, and water is not added to maintain the stabilization and function of the liposome-treated alcerioligo peptide-1.

In addition, since the method for treating the liposome is the same as that of the known method, a detailed description thereof will be omitted.

Next, a step of blending each raw material is performed. Prior to this, the blending device in which the raw material is blended is sterilized at high temperature.

That is, if the compounding temperature is set at a high temperature of about 70 ° C in the process of compounding each raw material, the compounding is smooth and the decay does not occur. On the other hand, the raw material, especially the ingredient of the main ingredient, Alzheimer's peptide- It is preferable to thoroughly clean the compounding device (main mixer) at a high temperature through a sterilization operation and a homogenizing operation before mixing each raw material.

In this case, sterilization is performed at a temperature of 180 to 200 ° C for 30 minutes to 1 hour at the time of dry heat sterilization, and at 126 to 130 ° C for 10 to 20 minutes at sterilization with high pressure steam.

[3] water soluble

The liposome-treated Alzheimer's peptide-1 is mixed with allantoin, which functions to promote the growth of skin tissue, with stirring at 49 to 50 rpm, preferably 50 rpm. During the mixing of these ingredients, And kept at 27 DEG C to prevent the function of the oligohyperopeptide-1 component from being degraded.

At this time, the liposome-treated Alzheimer's peptide-1 can actively react with the allantoin to further promote the growth of the cells.

Subsequently, a carbomer for viscosity control is added to the mixture. Since the carbomer has a high possibility of precipitation, it is stirred while being slowly mixed to the raw material.

In the present step, 98.00% by weight of the allantoic oligopeptide-1, 0.15-0.25% by weight of allantoin and 0.15-0.25% by weight of carbomer are used.

[4] First addition stirring

After the natural flavor and antioxidant are dispersed and dissolved, the mixture is added to the mixture of [3], and the mixture is stirred at 49 to 51 rpm at 25 to 27 ° C in the same manner as in the step [3].

Rosa Damascena Flower Oil and Olibanum are used as natural fragrances, and tocopheryl acetate is used as an antioxidant.

At this time, if the natural flavor and the antioxidant are added excessively, the ingredients of the aloe oligopeptide-1 may be destroyed while the compounding temperature of the raw material is increased. Therefore, 0.05% by weight of damask rose oil and 0.025% To 0.075% by weight, and tocopheryl acetate is used in an amount of 0.25 to 0.35% by weight.

[5] Second addition stirring

Arginine is added as an acidity regulator. In the case of alginate powder, when it is dispersed in the absence of purified water, it can not be uniformly mixed with other raw materials. Therefore, 5: 1, and then the mixture is added to the mixture of the step [4] and mixed at a temperature of 25 to 27 ° C at 49 to 51 rpm while being stirred and dispersed.

In this step, the amount of arginine used is 0.20 wt% and the amount of the oligohydropeptide-1 used is 1.0 wt%.

[6] filtration and packaging

The emulsion-state combination obtained in the above step [5] is filtered to a size of 300 mesh to obtain a final cosmetic raw material.

At this time, the floating matter floating on the upper part is repeatedly subjected to the filtration process to obtain a cosmetic raw material. The obtained cosmetic raw material is hermetically packed in a container so as not to be denatured by contact with oxygen.

The present invention can maximize the advantages of the active ingredient of each raw material by controlling the mixing ratio while maintaining the mixing temperature at 25 to 27 ° C and the pH at 7.0 to 7.7 during each step as described above, It is possible to prevent denaturation by these conditions.

Claims

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(A) sterilizing the compounding apparatus at a temperature of from 180 to 200 ° C for sterilization by dry heat and at a temperature of from 126 to 130 ° C for sterilization by high pressure steam;
(B) liposome treatment of Alzheimer ' s peptide-1 and part of it is put into the compounding device;
Adding allantoin to the compounding device, slowly adding carbomer thereto, stirring the mixture at a temperature of 25 to 27 ° C at 49 to 50 rpm,
Dispersing and dissolving osmotic rosemary oil, olivanium and tocopheryl acetate in a mixing device, stirring the mixture at a temperature of 25 to 27 ° C at 49 to 50 rpm;
Mixing the other part of the liposome-treated Alzheimer's peptide-1 of the step (b) with arginine by dispersing and mixing; mixing the mixture at a temperature of 25 to 27 ° C at 49 to 50 rpm; And
(B) filtering and separating the mixture formulated in step (c).

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The method of claim 3,
Wherein the liposome-treated liposome-treated liposomes are dispersed and mixed at a ratio of 5: 1 by weight.