KR101604428B1 - 불안증 치료제 - Google Patents

불안증 치료제 Download PDF

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Publication number
KR101604428B1
KR101604428B1 KR1020107000604A KR20107000604A KR101604428B1 KR 101604428 B1 KR101604428 B1 KR 101604428B1 KR 1020107000604 A KR1020107000604 A KR 1020107000604A KR 20107000604 A KR20107000604 A KR 20107000604A KR 101604428 B1 KR101604428 B1 KR 101604428B1
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South Korea
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anxiety
arg
delete delete
xaa
prt
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Expired - Fee Related
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KR1020107000604A
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English (en)
Korean (ko)
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KR20100038366A (ko
Inventor
앤드류 타스커
트레이시 도우세티
마이클 티미안스키
케네쓰 멘도자
마이클 피. 벨마레스
데이비드 갈만
피터 에스. 루
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노노 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1787—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020107000604A 2007-07-03 2008-07-02 불안증 치료제 Expired - Fee Related KR101604428B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94789207P 2007-07-03 2007-07-03
US60/947,892 2007-07-03

Publications (2)

Publication Number Publication Date
KR20100038366A KR20100038366A (ko) 2010-04-14
KR101604428B1 true KR101604428B1 (ko) 2016-03-17

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KR1020107000604A Expired - Fee Related KR101604428B1 (ko) 2007-07-03 2008-07-02 불안증 치료제

Country Status (10)

Country Link
US (2) US8008253B2 (https=)
EP (1) EP2175873B1 (https=)
JP (2) JP5775303B2 (https=)
KR (1) KR101604428B1 (https=)
CN (1) CN101827604B (https=)
AU (1) AU2008272903B2 (https=)
CA (1) CA2692412C (https=)
DK (1) DK2175873T3 (https=)
ES (1) ES2555172T3 (https=)
WO (1) WO2009006548A2 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008253B2 (en) 2007-07-03 2011-08-30 Andrew Tasker Treatment for anxiety
DK2307035T3 (da) * 2008-05-16 2014-01-20 Nono Inc Anvendelse af en PSD-95 inhibitor ved behandlingen af epilepsi
CA2739416C (en) * 2008-09-03 2017-10-31 Arbor Vita Corporation Agents and methods for treatment of pain
EP2841063A2 (en) * 2012-04-27 2015-03-04 Indiana University Research and Technology Corporation Compositions and methods for treating ptsd and related diseases
EP3067400A4 (en) 2013-11-05 2017-06-07 Mitsubishi Plastics, Inc. Adhesive composition
JP6388023B2 (ja) 2014-03-10 2018-09-12 三菱ケミカル株式会社 画像表示装置構成用積層体の製造方法
WO2015181756A1 (en) * 2014-05-28 2015-12-03 Nono Inc. Chloride salt of tat-nr2b9c
EP3383429B1 (en) 2015-11-30 2020-10-14 INSERM - Institut National de la Santé et de la Recherche Médicale Nmdar antagonists for the treatment of tumor angiogenesis
CN112760043A (zh) 2016-02-08 2021-05-07 三菱化学株式会社 透明两面粘合片及粘合片层叠体
WO2017138544A1 (ja) 2016-02-08 2017-08-17 三菱ケミカル株式会社 透明両面粘着シート及び粘着シート積層体
CN107312069B (zh) * 2016-04-27 2018-11-06 拜西欧斯（北京）生物技术有限公司 兴奋性神经毒性相关损伤的治疗肽
KR102253900B1 (ko) * 2016-04-27 2021-05-18 바이오셀즈(베이징) 바이오테크 코., 엘티디. 흥분성 신경독성 관련 손상 치료용 펩타이드
CN106632601B (zh) * 2016-11-16 2020-10-20 中国科学院昆明动物研究所 一种阻断突触长时程增强（ltp）的短肽及其应用
KR102403089B1 (ko) * 2017-07-05 2022-06-02 바이오셀즈(베이징) 바이오테크 코., 엘티디. 폴리펩타이드의 약학적으로 허용 가능한 염 및 이의 용도
KR102545825B1 (ko) * 2017-09-30 2023-06-22 바이오셀즈(베이징) 바이오테크 코., 엘티디. 흥분성 신경 독성 관련 손상 치료를 위한 펩타이드 조성물
FR3075038B1 (fr) 2017-12-15 2020-03-06 Melchior Material And Life Science France Utilisation de la fluoroethylnormemantine pour la prevention de l'apparition et le traitement de l'anxiete
US20220370546A1 (en) * 2019-11-05 2022-11-24 Kyoto University Peptide, composition, and method for treating, preventing, or ameliorating mood disorder
CN111285923B (zh) * 2020-03-05 2023-02-03 成都奥达生物科技有限公司 一种psd-95抑制剂
CN113735938B (zh) 2021-07-30 2024-11-08 英纳氏(珠海)药业有限公司 一种神经保护多肽化合物及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045535A2 (en) 2002-11-14 2004-06-03 Arbor Vita Corporation Molecular interactions in neurons
WO2007079406A1 (en) 2005-12-30 2007-07-12 Arbor Vita Corporation Small molecule inhibitors of pdz interactions

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6723838B1 (en) 1998-04-22 2004-04-20 Johns Hopkins University Signal transducing synaptic molecules and uses thereof
US20060148711A1 (en) * 1999-05-14 2006-07-06 Arbor Vita Corporation Molecular interactions in neurons
US6942981B1 (en) 1999-05-14 2005-09-13 Arbor Vita Corporation Method of determining interactions with PDZ-domain polypeptides
US7595297B2 (en) * 1999-06-02 2009-09-29 Michael Tymianski Method of reducing injury to mammalian cells
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6432985B2 (en) * 2000-04-25 2002-08-13 Hoffmann-La Roche Inc. Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists
AU2001270149A1 (en) 2000-06-26 2002-01-08 Merck & Co., Inc. Iminopyrimidine nmda nr2b receptor antagonists
FI20012082A0 (fi) 2001-10-26 2001-10-26 Paeivi Liesi Biologisesti aktiiviset peptidit hermovauroiden korjaamiseksi
US6713490B2 (en) * 2002-04-26 2004-03-30 Pfizer, Inc. 3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
GB0303613D0 (en) * 2003-02-17 2003-03-19 Novartis Ag Use of organic compounds
US20050084880A1 (en) 2003-07-11 2005-04-21 Ronald Duman Systems and methods for diagnosing & treating psychological and behavioral conditions
US20070105902A1 (en) 2003-11-12 2007-05-10 Lindsley Craig W 4-Phenyl piperdine sulfonyl glycine transporter inhibitors
HU226977B1 (en) * 2004-07-29 2010-04-28 Richter Gedeon Nyrt Kynurenic acid amide derivatives, pharmaceutical compositions containing them and process for producing them
US20060167075A1 (en) 2005-01-25 2006-07-27 Pearson James P Modulators of FAAH
US20060216331A1 (en) 2005-02-28 2006-09-28 Lines Thomas C Composition for treating mental health disorders
CA2613012A1 (en) * 2005-06-23 2007-01-04 Arbor Vita Corporation Methods and compositions for modulating cox
US8262847B2 (en) * 2006-12-29 2012-09-11 Lam Research Corporation Plasma-enhanced substrate processing method and apparatus
US8008253B2 (en) 2007-07-03 2011-08-30 Andrew Tasker Treatment for anxiety
US8080518B2 (en) * 2007-12-05 2011-12-20 Arbor Vita Corporation Co-administration of an agent linked to an internalization peptide with an anti-inflammatory

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045535A2 (en) 2002-11-14 2004-06-03 Arbor Vita Corporation Molecular interactions in neurons
WO2007079406A1 (en) 2005-12-30 2007-07-12 Arbor Vita Corporation Small molecule inhibitors of pdz interactions

Also Published As

Publication number Publication date
EP2175873A4 (en) 2011-10-05
JP2010532761A (ja) 2010-10-14
EP2175873B1 (en) 2015-11-11
KR20100038366A (ko) 2010-04-14
US20120083449A1 (en) 2012-04-05
JP5775303B2 (ja) 2015-09-09
CN101827604B (zh) 2014-05-07
JP2014129353A (ja) 2014-07-10
ES2555172T3 (es) 2015-12-29
CA2692412C (en) 2017-02-07
US8536129B2 (en) 2013-09-17
AU2008272903A8 (en) 2010-05-06
AU2008272903A1 (en) 2009-01-08
WO2009006548A2 (en) 2009-01-08
CN101827604A (zh) 2010-09-08
US8008253B2 (en) 2011-08-30
DK2175873T3 (en) 2015-12-14
US20090036376A1 (en) 2009-02-05
AU2008272903B2 (en) 2013-08-29
EP2175873A2 (en) 2010-04-21
WO2009006548A3 (en) 2009-03-19
CA2692412A1 (en) 2009-01-08

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