KR101604119B1 - 신규한 c-아릴 안사 sglt2 억제제 - Google Patents
신규한 c-아릴 안사 sglt2 억제제 Download PDFInfo
- Publication number
- KR101604119B1 KR101604119B1 KR1020147000343A KR20147000343A KR101604119B1 KR 101604119 B1 KR101604119 B1 KR 101604119B1 KR 1020147000343 A KR1020147000343 A KR 1020147000343A KR 20147000343 A KR20147000343 A KR 20147000343A KR 101604119 B1 KR101604119 B1 KR 101604119B1
- Authority
- KR
- South Korea
- Prior art keywords
- chloro
- formula
- ring
- compound
- mmol
- Prior art date
Links
- RTSUALVTSAXDSS-UHFFFAOYSA-N C1C2CCCB12 Chemical compound C1C2CCCB12 RTSUALVTSAXDSS-UHFFFAOYSA-N 0.000 description 1
- VGIYQYFPSCCPLL-OXFURMMHSA-N CCOc1ccc(Cc(c(Cl)c2)cc([C@@H]([C@@H]([C@H]3OC(C)=O)OC(C)=O)O[C@H](COC(C)=O)[C@H]3OC(C)=O)c2OCC=C)cc1 Chemical compound CCOc1ccc(Cc(c(Cl)c2)cc([C@@H]([C@@H]([C@H]3OC(C)=O)OC(C)=O)O[C@H](COC(C)=O)[C@H]3OC(C)=O)c2OCC=C)cc1 VGIYQYFPSCCPLL-OXFURMMHSA-N 0.000 description 1
- AQFAXGQLVGIFEU-GPEXLQPFSA-N CCOc1ccc(Cc(c(Cl)c2)cc([C@@H]([C@@H]([C@H]3OCc4ccccc4)OCc4ccccc4)O[C@H](COCC=C)[C@H]3OCc3ccccc3)c2OCC=C)cc1 Chemical compound CCOc1ccc(Cc(c(Cl)c2)cc([C@@H]([C@@H]([C@H]3OCc4ccccc4)OCc4ccccc4)O[C@H](COCC=C)[C@H]3OCc3ccccc3)c2OCC=C)cc1 AQFAXGQLVGIFEU-GPEXLQPFSA-N 0.000 description 1
- GCSCWCZSEXNNFG-NXMQPOSQSA-N CCOc1ccc(Cc(c(Cl)c2)cc([C@@H]([C@@H]([C@H]3OCc4ccccc4)OCc4ccccc4)O[C@H](COCCCCCO)[C@H]3OCc3ccccc3)c2OCC=C)cc1 Chemical compound CCOc1ccc(Cc(c(Cl)c2)cc([C@@H]([C@@H]([C@H]3OCc4ccccc4)OCc4ccccc4)O[C@H](COCCCCCO)[C@H]3OCc3ccccc3)c2OCC=C)cc1 GCSCWCZSEXNNFG-NXMQPOSQSA-N 0.000 description 1
- XEQRXCJBOKBZCY-BRTFYBOSSA-N CCOc1ccc(Cc(c(Cl)c2)cc([C@@H]([C@@H]3OCc4ccccc4)O[C@H](COCc4ccccc4)C(OCc4ccccc4)=C3OCc3ccccc3)c2OCC=C)cc1 Chemical compound CCOc1ccc(Cc(c(Cl)c2)cc([C@@H]([C@@H]3OCc4ccccc4)O[C@H](COCc4ccccc4)C(OCc4ccccc4)=C3OCc3ccccc3)c2OCC=C)cc1 XEQRXCJBOKBZCY-BRTFYBOSSA-N 0.000 description 1
- LBRUVLGYNOUPCT-DKMSJILLSA-N CCOc1ccc(Cc(c(Cl)c2)cc3c2OC/C=C\COC[C@H]([C@H]([C@@H]2OC(C)=O)OC(C)=O)O[C@@H]3[C@@H]2OC(C)=O)cc1 Chemical compound CCOc1ccc(Cc(c(Cl)c2)cc3c2OC/C=C\COC[C@H]([C@H]([C@@H]2OC(C)=O)OC(C)=O)O[C@@H]3[C@@H]2OC(C)=O)cc1 LBRUVLGYNOUPCT-DKMSJILLSA-N 0.000 description 1
- JKRYYXJLQDAMGR-VBLURBSVSA-N CCOc1ccc(Cc(c(Cl)c2)cc3c2OCCCCCOC[C@H]([C@H]([C@@H]2OCc4ccccc4)OCc4ccccc4)O[C@@H]3[C@@H]2OCc2ccccc2)cc1 Chemical compound CCOc1ccc(Cc(c(Cl)c2)cc3c2OCCCCCOC[C@H]([C@H]([C@@H]2OCc4ccccc4)OCc4ccccc4)O[C@@H]3[C@@H]2OCc2ccccc2)cc1 JKRYYXJLQDAMGR-VBLURBSVSA-N 0.000 description 1
- KWHJCXJWRDCRNS-RTJMFUJLSA-N CCOc1ccc(Cc(cc([C@@H]([C@@H]([C@H]2O)O)O[C@H](COCCCCCO3)[C@H]2O)c3c2)c2Cl)cc1 Chemical compound CCOc1ccc(Cc(cc([C@@H]([C@@H]([C@H]2O)O)O[C@H](COCCCCCO3)[C@H]2O)c3c2)c2Cl)cc1 KWHJCXJWRDCRNS-RTJMFUJLSA-N 0.000 description 1
- JLLGTIOLQFBCGJ-RXFVIIJJSA-N CSc1ccc(Cc(c(Cl)c2)cc3c2OCCCCCOC[C@H]([C@H]([C@@H]2O)O)O[C@@H]3[C@@H]2O)cc1 Chemical compound CSc1ccc(Cc(c(Cl)c2)cc3c2OCCCCCOC[C@H]([C@H]([C@@H]2O)O)O[C@@H]3[C@@H]2O)cc1 JLLGTIOLQFBCGJ-RXFVIIJJSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161496805P | 2011-06-14 | 2011-06-14 | |
| US61/496,805 | 2011-06-14 | ||
| PCT/KR2012/004703 WO2012173410A2 (fr) | 2011-06-14 | 2012-06-14 | Nouveaux inhibiteurs c-aryle ansa de sglt2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140027449A KR20140027449A (ko) | 2014-03-06 |
| KR101604119B1 true KR101604119B1 (ko) | 2016-03-16 |
Family
ID=47357612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147000343A KR101604119B1 (ko) | 2011-06-14 | 2012-06-14 | 신규한 c-아릴 안사 sglt2 억제제 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US8921412B2 (fr) |
| KR (1) | KR101604119B1 (fr) |
| WO (1) | WO2012173410A2 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014CH01141A (fr) * | 2014-03-06 | 2015-09-11 | Msn Lab Private Ltd | |
| CN113214197B (zh) * | 2021-04-07 | 2022-08-09 | 山东省药学科学院 | 一种维生素c乙基醚的制备方法 |
| CN113321577A (zh) * | 2021-06-28 | 2021-08-31 | 上海立科化学科技有限公司 | 5-溴-2-氯苯甲酸的制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080096923A1 (en) | 2004-07-23 | 2008-04-24 | Aniz Girach | Methods For Diagnosing And Treating Diabetic Microvascular Complications |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW343965B (en) * | 1994-03-30 | 1998-11-01 | Hoffmann La Roche | Novel mono- and bicyclic DNA gyrase inhibitors |
-
2012
- 2012-06-14 KR KR1020147000343A patent/KR101604119B1/ko active IP Right Grant
- 2012-06-14 US US14/123,793 patent/US8921412B2/en active Active
- 2012-06-14 WO PCT/KR2012/004703 patent/WO2012173410A2/fr active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080096923A1 (en) | 2004-07-23 | 2008-04-24 | Aniz Girach | Methods For Diagnosing And Treating Diabetic Microvascular Complications |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140027449A (ko) | 2014-03-06 |
| US20140213642A1 (en) | 2014-07-31 |
| WO2012173410A3 (fr) | 2013-03-28 |
| WO2012173410A2 (fr) | 2012-12-20 |
| US8921412B2 (en) | 2014-12-30 |
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