KR101559515B1 - Composition of the functional feed additive - Google Patents

Abstract

The present invention relates to a functional food composition and a feed composition containing the same. According to the present invention, the additive composition for the functional animal feed includes: glucosamine HCl; chondroitin sulfate; methyl sulfony methane; vitamin C; vitamin E; Carthamus tinctorius seeds; Curcuma longa; Hizikia fusiformis; Cirsium japonicum; and Acanthopanax sessiliflorum Seeman. The present invention can provide the functional feed additive composition capable of preventing and alleviating joint diseases as well as a feed composition which contains the functional feed additive composition and energy source and protein nutrients at a ratio appropriate to nurture the puppies of detection gods. The present invention uses natural ingredients to be easily and safely consumed while ensuring excellent economical effect.

Description

COMPOSITION OF THE FUNCTIONAL FEED ADDITIVE [0002]

TECHNICAL FIELD The present invention relates to a functional feed additive composition and a feed composition containing the same, and more particularly, to a functional feed additive composition containing a functional ingredient effective for osteoarthritis such as osteochondrosis, hip dysplasia, osteoarthritis, And an animal feed composition suitable for nursing dogs that contain the animal feed composition.

Joint-related disorders are common in large dogs such as Osteochondrosis, Hip dysplasia, Osteoarthritis (osteoarthritis) and Shepherd. There are few companies that have conducted substantial animal research while developing dog food, (Shepard et al.) And foreign cultivars (arthritis, etc.), and applied them to special dogs.

For reference, the number of special dogs by domestic institution varies by breed, but currently there are about 2,300 dogs with 6 government agencies. Most of them have German Shepherd species and most of them are used for detection purpose.

As a result of domestic researches, there are few companies that have conducted actual animal research experiments while developing pet dog food, except for Purina food (having a pet experiment farm) because of the history of domestic pet food for 20 years. Especially, there is no research on special dog food being. There is only a part of experiment (dog owners, veterinarians) applied to the food imported from foreign countries (such as three parts) and the treatment method (arthritis). In foreign countries, alleviation and prevention of arthritis, Glucosamine, Chondrotin, Omega-3, EFA, and Antioxidants are added to Shepherd's diet. Green-Lipped Mussel is added to the arthritis formula.

Therefore, it is required to develop a functional food additive composition of Korean type which can differentiate it from foreign products by studying new materials containing cartilage protective ingredients and the like and adding them to shepherd feed.

Also, it is required to develop customized feed for the promotion of health and development of special dogs for detection purposes. There are very few animals in Korea that have conducted practical animal research experiments while developing dog food. Especially, there is no research on the detection dog feeds. Therefore, it is necessary to experiment on the feeds of imported varieties (such as Shepard) And to apply it to the detection dog. In addition, there are many cases in which the foreign ingredient of the feed is the trade secret of each company, and the situation of the special dog for detection purpose in Korea is not taken into consideration in total. In order to develop the feed suitable for domestic detection purpose dog, It is necessary to develop feeds by calculating the nutrient requirement.

Korean Patent No. 10-0973192 (Functional feed composition for improving arthritis of senile dogs), Korean Patent Laid-Open No. 10-2011-0038631 (cartilage regeneration, herbal composition for suppressing pain and edema) Korea Patent No. 10-0676589 (a method of reducing femoral joint relaxation), and the like.

The present inventors have found that glucosamine hydrochloride (glucosamine HCl), chondroitin sulfate, methyl sulfony methane, vitamin C, vitamin E, safflower seed, turmeric, The present inventors have completed the present invention by experimentally confirming that inflammation of arthritis is remarkably improved as a result of feeding to dogs (dogs).

In conclusion, one object of the present invention is to provide a pharmaceutical composition containing glucosamine hydrochloride, chondroitin sulfate, methylsulfonyl methane, vitamin C, vitamin E, safflower seed, turmeric, Or a pharmaceutically acceptable salt thereof.

Furthermore, the present inventors confirmed that when the appropriate amounts of the protein nutrients and the energy source nutrients (calories) necessary for nursing of the dog (Shepard) dogs were included in the feed, the increase in body weight per day of the dogs was excellent.

Accordingly, an object of the present invention is to provide a feed composition for a dog to be cared for, which contains a functional feed additive for arthritis prevention and improvement and is suitable for raising a dog (Shepard) dog.

In order to achieve the above object, the present invention provides a pharmaceutical composition comprising glucosamine hydrochloride, chondroitin sulfate, methyl sulfonyl methane, vitamin C, vitamin E, safflower seed, turmeric, Or a pharmaceutically acceptable salt thereof.

10 to 15% by weight of the composition glucosamine hydrochloride, 3 to 7% by weight of chondroitin sulfate, 10 to 30% by weight of methylsulfonyl methane, 9 to 10% by weight of vitamin C, The present invention is characterized in that it comprises 0.5 to 1.0% by weight of vitamin E, 5 to 15% by weight of safflower, 5 to 15% by weight of turmeric, 5 to 15% by weight of topsoil, 5 to 15% by weight of thistle and 5 to 15%

The chondroitin sulfate is characterized by being extracted from pine trees.

The composition is characterized by being effective in improving arthritis of an animal.

The animal is characterized as being individual.

The present invention also relates to the use of an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for use in an animal, including glucosamine hydrochloride, chondroitin sulfate, methylsulphonyl methane, vitamin C, vitamin E, safflower seed, turmeric, Wherein the feed additive composition comprises 27 to 37% by weight of a protein nutrient and 3,300 to 4,300 kcal / kg of a calorie dog feed composition.

The detection dog is characterized by shepherd.

According to the present invention, glucosamine hydrochloride, chondroitin sulfate, methyl sulfonyl methane, vitamin C, vitamin E, safflower seed, turmeric, top, thistle and ogapi are included. A functional feed additive composition capable of preventing and alleviating joint diseases can be provided, and a functional feed additive composition capable of preventing and alleviating joint diseases can be provided, And a feed composition containing an appropriate ratio of protein nutrients and energy source nutrients (calories). Such a functional feed additive composition and a feed composition for the detection of dogs can be safely and easily ingested by using natural materials and have excellent economical efficiency.

Figure 1 lists candidate materials 1 to 10.
Figure 2 lists candidates 11-20.
Figure 3 lists candidates 21-30.
Figure 4 lists the candidate materials 31-40.
5 lists candidate materials 41-50.
6 shows X-ray photographs showing the effect of the functional feed additive composition.
FIG. 7 is a graph showing the daily gain per unit of protein level.
FIG. 8 is a graph for calculating the daily gain amount according to the energy nutrient (calorie) level.
FIG. 9 is a photograph of a feed feeding experiment using Shepard dogs.

Hereinafter, the present invention will be described in detail.

The term "protein nutrient" in the present invention means the total of all the protein component elements obtained from the animal feed. Expressed as% by weight relative to the weight of the whole feed.

The term "energy source nutrient" in the present invention means the total amount of all the nutrients that an animal can obtain from a feed and use as an energy source of self. In most cases the meaning is the same as the "calories" of the feed. It is expressed in calories per kilogram of total feed (kcal).

The present invention relates to an animal feed composition comprising an animal functional food comprising glucosamine hydrochloride, chondroitin sulfate, methyl sulfony methane, vitamin C, vitamin E, safflower seed, turmeric, An additive composition is provided.

Wherein the composition comprises 10 to 15% by weight of glucosamine hydrochloride, 3 to 7% by weight of chondroitin sulfate, 10 to 30% by weight of methylsulphonium methane, 9 to 10% by weight of vitamin C, , 5 to 10% by weight of vitamin E, 5 to 15% by weight of safflower seeds, 5 to 15% by weight of turmeric, 5 to 15% by weight of topsoil, 5 to 15% by weight of thistle, and 5 to 15% More preferably 12.8% by weight of glucosamine hydrochloride, 5% by weight of chondroitin sulfate, 20% by weight of methylsulfonyl methane, 9.4% by weight of vitamin C, 0.8% by weight of vitamin E, 12% by weight of safflower seed, 10% by weight of turmeric, 10% by weight of top seed, 10% by weight of thistle seed and 10% by weight of omega or glucosamine hydrochloride, 5% by weight of chondroitin sulfate, 27% by weight of methylsulfonyl methane, 9.4% by weight of vitamin C, 0.8% by weight of vitamin E, 9% by weight of safflower seeds, 9% by weight of turmeric, 9% by weight of garnet, 9% by weight of thistle and 9% .

The chondroitin sulfate is characterized by being extracted from pine trees.

The functional feed additive composition for animals is characterized in that it is effective for improving arthritis of an animal.

The animal is characterized as being individual.

The present invention also relates to a pharmaceutical composition for the treatment and prophylactic use of an animal including a glucosamine hydrochloride (glucosamine HCl), chondroitin sulfate, methylsulphonyl methane, vitamin C, vitamin E, safflower seed, turmeric, Wherein the feed additive composition comprises 27 to 37% by weight of a protein nutrient and 3,300 to 4,300 kcal / kg of a calorie dog feed composition. When the protein nutrient content is less than 27% by weight, raising of the dog is not smooth, and when the protein nutrient content is more than 37% by weight, the economical efficiency of the feed is insufficient. When the calorific value of the energy source is less than 3,300 kcal / kg, the breeding of the dogs is not smooth, and when the calorific value is 4,300 kcal / kg or more, the economical efficiency of the feed is insufficient. It is more preferable that the protein nutrient content is 31 to 34% by weight, and the calorie content is 3,500 to 3,900 kcal / kg.

The detection dog is characterized by shepherd.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these examples are for illustrative purposes only and that the scope of the present invention is not construed as being limited by these examples.

Example 1. Selection of candidate substances

A total of 50 candidate substances were selected mainly from the main active ingredients through the literature and visiting surveys, such as materials used for prevention of diseases such as joint diseases of special dogs and health promotion (see FIGS. 1 to 5) ), The characteristics of the investigated candidate substances were analyzed, and ten candidates were confirmed as shown in Table 1 below in consideration of applicability and economic efficiency.

[Table 1]

Experimental Example 1. Effectiveness of functional feed additive composition according to the present invention

(1) Two types of joint health enhancers (formula 1 and 2) were prepared by combining the candidates selected in Example 1 above (Table 2) and a special dog having abnormal operation and joint health . The target dogs were 24 dogs with no disease or non - operative special dogs (15 dogs of Jinju Air Force Educational Headquarters, 9 Chuncheon Army Training Units). On the other hand, the pay period and method were fed in capsules of 1000 ㎎ / d for four months from October 2013 to January 2014.

[Table 2]

Thereafter, the following tests were performed every 2 months (0, 2, 4 months).

(2) Blood component test results including immune components (IL-1b, IL-6, TNFα, CRP, etc.)

As shown in Table 3 and Table 4 below, the serum concentrations of IFN-γ were 24.7 to 91.9 pg / ml in the 9th, 15th, and 20th dogs before administration of the additive substance, , But not after 2-4 months of dosing.

In the case of dogs 6, 8, 15, and 19, the serum concentration of inflammatory cytokine IL-1β was measured 13.2-525.3 pg / ml before the administration of additive substance, It was not detected after 4 months of dosing. However, IL-1β levels in the 6th dog were increased to 1982.9 and decreased to 986.1 pg / ml.

Serum concentrations of inflammatory cytokines IL-6 were detected in most of the dogs, except 4, 5, 6, 9, 12, and 19 dogs, of 24 dogs before supplementation, Serum concentrations of IL-6 did not change during the feed additive periods (1, 2, 10, 13, 16, 18, 22). Serum IL-6 levels were increased in some cases (4, 5, 6, 9, 17, 18, 19, 23, 24 times) , 11, 14, 16, 20, 21).

Serum concentrations of inflammatory cytokines TNF-α were detected in dogs 2, 18, 19, 21, and 22. Serum concentrations of Matrix metalloproteinase (MMP) -2 / -3, an inflammation factor, were detected in the 7th dog group. Serum concentrations of MMP-2 and MMP-3 were decreased in the dogs fed with the additive materials.

Overall, it was found that the immune function of the dogs was activated after the health promotion substance.

[Table 3]

[Table 4]

(3) Results of joint x-ray examination

As shown in Fig. 6, it was found that there was a positive change to the extent that it can be distinguished by the naked eye.

Experimental Example 2. Determination of Protein Nutrient Requirement of Functional Feed According to the Present Invention

(1) To confirm the protein nutrient requirement of the functional feed containing the functional additives combined with the candidate substances selected in Example 1 above, Shepard dogs were tested. Target Shepard puppies were 5-month-old female and 9 male Shepard puppies. Crude protein (CP) treatments were divided into three groups: CP1 (content 27.5%), CP2 (content 32.0%) and CP3 (content 36.5%).

The composition of each treatment was as shown in Table 5 below, and the 'health enhancing functional material' used was a composition material of formula 1 of Experimental Example 1. [ The crude protein ratio is indicated in the 'CP' column.

[Table 5]

(2) Experimental results of weight gain of protein in the feed of Shepard dog

As a result of feeding experiments with different protein levels at different treatments for 15 days (excluding feed adaptation period) of 3 to 2 treatments per day, the daily gain of the three treatments was 0.101 kg / day, 0.140 kg / day, 0.116 kg / day. As a result of regression analysis in the form of a graph, it was confirmed that the same shape as in FIG. 7 was obtained, and it was found that the highest weight gain was obtained when the CP was fed at a level of 32.46%.

Therefore, it can be said that the optimal feedstock for the health promotion of the dog (Shepard dog) is CP 32.46%, which is the optimum content of crude protein.

Experimental Example 3. Determination of energy nutrient (calorie) requirement of functional feed according to the present invention

(1) Experiments were conducted to confirm the energy nutrient requirement (calories) of the functional feed containing the functional additives combined with the candidate substances selected in Example 1 above. Target Shepard puppies were 7 months old and 9 male Shepard dogs. The energy nutrient (calorie) treatment was divided into 3 types: E 1 (3,325 kcal / kg), E 2 (3,784 kcal / kg) and E 3 (4,222 kcal / kg).

The composition of each treatment was as shown below (Table 6), and the 'health enhancing functional substance' used the composition material of formula 1 of Experimental Example 1. The calorie level per weight of energy nutrient (calories) is indicated in the 'EN' column.

[Table 6]

(2) Experimental results of weight gain by energy nutrient (calorie) level of feed for Shepard puppies

As a result of the feeding experiment with different energy nutrient (calorie) levels and three 15 - day feeding period (excluding feed adaptation period), the daily gain of the three treatments was 0.096 kg / day, 0.294 kg / day , And 0.236 kg / day, respectively. As a result of regression analysis in the form of a graph, it was confirmed that the same pattern as in FIG. 8 was obtained and that the highest amount of energy gain was shown when energy nutrients (calories) were fed at a level of 3,895 kcal / kg.

Therefore, it can be said that the optimum feed dietary energy source is to adjust the energy nutrient (calories) to 3,895 kcal / kg for the development of healthy dogs (Shepard dogs).

Experimental Example 4: Confirmation of effect of functional food according to the present invention

(1) Experiments were conducted on Shepard dogs in order to confirm the efficacy of a functional food containing a functional additive selected from the above-mentioned Example 1 and a protein and energy requirement (calories). Target Shepard dogs were 10 months old and 8 sheep sheep were male.

The composition of the experimental diets was as shown in Table 7 below.

[Table 7]

(2) Test results of the effect of functional feed

As a result of long term feeding test, the same experimental results as in Table 8 were obtained. The results obtained were almost the same as those of the control dog, R. The results were almost the same as those of the foreign dogs whose composition ratio was not known. Therefore, the value of the dog was confirmed as a special dog for Shepard dogs.

[Table 8]

Having described specific portions of the present invention in detail, those skilled in the art will appreciate that these specific embodiments are merely preferred embodiments and that the scope of the present invention is not limited thereby. something to do. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

Claims (7)

Glucosamine hydrochloride, chondroitin sulfate, methylsulphonyl methane, vitamin C, vitamin E, safflower seed, turmeric, top, thistle and ogapi,
12.8% by weight of glucosamine hydrochloride, 5% by weight of chondroitin sulfate, 27% by weight of methylsulphonyl methane, 9.4% by weight of vitamin C, 0.8% by weight of vitamin E, 9% 9% by weight of turmeric, 9% by weight of garnet, 9% by weight of thistle, and 9% by weight of omega-9.
delete The method according to claim 1,
Wherein the chondroitin sulfate is extracted from pine trees.
The method according to claim 1,
Wherein the composition is effective for improving arthritis of Shepard.
delete 12.8% by weight of glucosamine hydrochloride, 5% by weight of chondroitin sulfate, 27% by weight of methylsulphonyl methane, 9.4% by weight of vitamin C, 0.8% by weight of vitamin E, 9% , 9% by weight of turmeric, 9% by weight of tops, 9% by weight of thistles and 9% by weight of an ophthalmic composition,
Wherein the protein nutrient content is 31 to 34% by weight, and the calorie content is 3,500 to 3,900 kcal / kg.
delete

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