KR102168587B1 - Pet joint nutritional supplement composition - Google Patents

Abstract

The present invention relates to a pet joint nutrition composition comprising: 20-35 wt% of methylsulfonylmethane (MSM); 5-15 wt% of N-acetylglucosamine; 1-10 wt% of a green-lipped mussel; 2-7 wt% of mucopolysaccharide protein; 1-10 wt% of omega 3 powder (DHA/EPA); 1-10 wt% of dry yeast; 1-15 wt% of hydrolyzed salmon powder; 1-10 wt% of fructooligosaccharide; 1-10 wt% of glucose; 1-15 wt% of crystalline cellulose; and 0.2-3 wt% of cheese flavor based on a total weight of the composition. The present invention can provide effects of effectively preventing and treating a joint disease of a pet without side effects.

Description

Pet joint nutritional supplement composition

The present invention relates to a companion animal joint nutritional composition.

Pets are recognized as companion animals and members of the family. Therefore, it has become an important task for the happiness of families with pets to live together for a long time without diseases.

Diseases associated with the aging of mammals include joint disorders, vascular system abnormalities, and the occurrence of various cancers, and these appear as complex conditions. Therefore, people with pets suffer psychological and economic hardships related to the treatment costs and euthanasia treatments associated with old age.

In the case of joint disease that occurs in pets, it appears in various forms, such as rheumatoid arthritis, osteoarthritis, arthritis due to excessive exercise, periarthritis, and deformed arthritis that occur in mammals and humans. In particular, in pets such as elderly dogs, osteoarthritis and periarthritis are common diseases.

Regarding these joint diseases, cure through good treatment is the next best option, and the best option is to find a way to prevent and alleviate the condition before it develops. In the treatment of joint disorders in elderly pets, glucosamine or chondroitin sulfate is usually used. In addition, recently, methylsulfonylmethane (MSM) has been used as a major component of joint nutrition.

However, a reliable nutrient that can prevent and treat joint diseases in these elderly pets is not yet sufficiently supplied.

Korean Patent Registration No. 10-1559515

The present invention was devised to solve the above problems of the prior art,

An object of the present invention is to provide a joint nutrient composition for companion animals that can be trusted and used because it can effectively prevent and treat joint diseases of companion animals without side effects.

In order to achieve the above object, the present invention

The present invention, based on the total weight of the composition, methylsulfonylmethane (MSM) 20 to 35% by weight; 5 to 15% by weight of N-acetylglucosamine; 1 to 10% by weight of green lipped mussels; 2 to 7% by weight of mucopolysaccharide; 1 to 10% by weight of omega 3 powder (DHA/EPA); 1 to 10% by weight of dry yeast; 1 to 15% by weight of hydrolyzed salmon powder; 1 to 10% by weight of fructooligosaccharide; 1 to 10% by weight of glucose; 1 to 15% by weight of crystalline cellulose; And cheese flavor 0.2 to 3% by weight; It provides a companion animal joint nutritional composition comprising.

The joint nutritional composition for companion animals of the present invention provides an effect that can effectively prevent and treat joint diseases in companion animals without side effects.

Hereinafter, the present invention will be described in detail.

The present invention, based on the total weight of the composition, methylsulfonylmethane (MSM) 20 to 35% by weight; 5 to 15% by weight of N-acetylglucosamine; 1 to 10% by weight of green lipped mussels; 2 to 7% by weight of mucopolysaccharide; 1 to 10% by weight of omega 3 powder (DHA/EPA); 1 to 10% by weight of dry yeast; 1 to 15% by weight of hydrolyzed salmon powder; 1 to 10% by weight of fructooligosaccharide; 1 to 10% by weight of glucose; 1 to 15% by weight of crystalline cellulose; And cheese flavor 0.2 to 3% by weight; It relates to a companion animal joint nutritional composition comprising.

The methylsulfonylmethane (MSM) is used as a main component of joint nutrition. The MSM usually has all different origins, and this MSM is extracted by a general crystallization purification method. In the crystallization purification method, since a large amount of water contaminated with heavy metals is used when preparing MSM, there is a problem of heavy metal contamination and purity is often not verified.

Therefore, in the present invention, OptiMSM (produced by Bergstrom Nutrition) certified in the United States is preferably used. The OptiMSM is extracted from natural pulp by distillation and refining and is free from heavy metal contamination and has an excellent purity of at least 99.8%. It is also free of gluten, allergy, and shellfish.

The mucopolysaccharide protein is a component containing chondroitin.

The nutrient composition further comprises 1 to 10% by weight of plant fermentation,

The plant fermentation product is

a) The step of chopping the plant mixture mixed with the weight ratio of 1 to 3: 1 to 3: 1 to 3 of Silene villosa, Nopal, and Lathyrus sativus, and putting it into a fermentation container ;

b) adding fig concentrate to the fermentation vessel, inoculating at least one strain of lactic acid bacteria and yeast, and fermenting for 2 weeks to 3 months;

c) preparing the fermented product of step b) in a slurry state; And

d) drying the slurry of step c) to prepare a powder.

The beach sirene (Silene villosa) of step a) is a desert plant and is known to grow on sandy beaches along the Mediterranean Sea. The present inventors confirmed that the beach sirene has arthritis inhibitory activity. In the present invention, flowers, stems, and leaves of seaside siren may be used.

In addition, the inventors of the present invention confirmed that Nopal and grass peas (Lathyrus sativus) have inhibitory activity against arthritis, and in particular, found that they provide excellent effects when fermented in combination with seaside cinene. Was completed.

In the present invention, a mixture of the above ingredients is fermented and used in order to improve the arthritis activity of the seaside sirene (Silene villosa), Nopal (Nopal), and grass pea (Lathyrus sativus).

In order to increase the activity of arthritis based on 100 parts by weight of the plant mixture, the present invention further comprises 1 to 10 parts by weight of broccoli, 1 to 10 parts by weight of Choseokjam, 1 to 10 parts by weight of capers and 1 to 10 parts by weight of sputum flowers Can include.

The broccoli, choseokjam, caper, and sputum sputum function to enhance the arthritis inhibitory activity of the plant mixture.

The caper is a plant native to the Mediterranean coast, and is a plant used as a spice by collecting and processing the buds of this plant, or pickling it in vinegar to form a pickle. The present inventors confirmed that the caper has an excellent inhibitory activity against arthritis and used it in the present invention.

The beard sputum flower is a medicinal plant used as a herbal medicine in oriental medicine and contains various physiologically active substances. Bearded sputum flowers are called Banbyeon, Banbyeonran, or Sudden Sea Color. In Korea, it is distributed in the south of the central region and Jeju Island, and lives in ditches, streams, and wetlands of rice fields. The sputum sputum has traditionally been used as a medicine to treat asthma, dyspnea, whooping cough, malignant boils, eczema, and traumatic bleeding. The present inventors have discovered and added that the sputum sputum has an activity against arthritis.

The lactic acid bacteria that can be used in the plant fermentation include Lactobacillus sp., Streptococcus sp., Pediococcus sp., and Leukonostoc sp. ), Bifidobacterium sp., and the like.

In addition, as the yeast, Saccharomyces sereviciae (Saccharomyces sereviciae), Saccharomyces rouxii, Saccharomyces oviformis (Saccharomyces oviformis), Saccharomyces steineri (Saccharomyces steineri) ), etc. may be used.

In the present invention, the fig concentrate may be used in an amount of 5 to 30 parts by weight based on 100 parts by weight of the plant mixture as sugar.

Hereinafter, the present invention will be described in more detail through examples. However, the following examples are for explaining the present invention more specifically, and the scope of the present invention is not limited by the following examples. The following examples can be appropriately modified and changed by those skilled in the art within the scope of the present invention.

Preparation Example 1: Preparation of plant fermentation

1 kg of a plant mixture obtained by mixing Silene villosa, Nopal, and Lathyrus sativus at a weight ratio of 2:1:1 was chopped and placed in a fermentation container. A total of 200 g of fig concentrate was put in the jar. Then, Streptococcus sp. strain was inoculated, the jar was sealed to allow air to pass through, and fermented in the shade at room temperature for 1 month. The fermented product was pulverized with a grinder to form a slurry, and dried to prepare a powder state.

Preparation Example 2: Preparation of plant fermentation

1 kg of a plant mixture obtained by mixing Silene villosa, Nopal, and Lathyrus sativus at a weight ratio of 2:1:1 was chopped and placed in a fermentation container. 30 g of broccoli, 30 g of choseokjam, 30 g of capers and 30 g of sputum flowers were put in the jar, and a total of 200 g of fig concentrate was added. Then, Streptococcus sp. strain was inoculated, the jar was sealed to allow air to pass through, and fermented in the shade at room temperature for 1 month. The fermented product was pulverized with a grinder to form a slurry, and dried to prepare a powder state.

Example 1: Companion animal joint nutrition composition

31% by weight of methylsulfonylmethane (OptiMSM); 11% by weight of N-acetylglucosamine; 8% green lipped mussels; 8% by weight of mucopolysaccharide; 7% by weight of omega 3 powder; 4.5% by weight of dry yeast; 10% by weight of hydrolyzed salmon powder; 5% by weight of fructooligosaccharide; 5% by weight of glucose; 10% by weight of crystalline cellulose; And cheese flavor 0.5% by weight; by mixing to prepare a joint nutritional composition.

Example 2: Companion animal joint nutrition composition

30% by weight of methylsulfonylmethane (OptiMSM); 10% by weight of N-acetylglucosamine; 7% by weight green lipped mussel; 7% by weight of mucopolysaccharide; 6% by weight of omega 3 powder; 4.5% by weight of dry yeast; 10% by weight of hydrolyzed salmon powder; 5% by weight of fructooligosaccharide; 5% by weight of glucose; 10% by weight of crystalline cellulose; 5% by weight of the plant fermentation product prepared in Preparation Example 1; And cheese flavor 0.5% by weight; by mixing to prepare a joint nutritional composition.

Example 3: Companion Animal Joint Nutritional Supplement Composition

30% by weight of methylsulfonylmethane (OptiMSM); 10% by weight of N-acetylglucosamine; 7% by weight green lipped mussel; 7% by weight of mucopolysaccharide; 6% by weight of omega 3 powder; 4.5% by weight of dry yeast; 10% by weight of hydrolyzed salmon powder; 5% by weight of fructooligosaccharide; 5% by weight of glucose; 10% by weight of crystalline cellulose; 5% by weight of the plant fermentation product prepared in Preparation Example 2; And cheese flavor 0.5% by weight; by mixing to prepare a joint nutritional composition.

Test Example 1: Analysis of Nutritional Components of Companion Animal Joint Nutritional Composition

The nutritional components of the nutritional composition prepared in Example 1 were analyzed as shown in Table 1 below.

Ingredient name Crude protein Crude fat calcium sign Crude fiber Minutes moisture Ingredient 12.0% or more 3.0% or more 0.07% or more More than 0.08% 16.0% or less 10.0% or less 14.0% or less

Test Example 2: Evaluation of Arthritis Inhibitory Activity of Companion Animal Joint Nutrient Composition

The arthritis inhibitory action was tested using a mouse collagen-induced arthritis model [Nature, 1980, Vol. 283, p.666-668].

Type 2 collagen (manufactured by collagen technology training company) and Freund's complete adjuvant (manufactured by Yatoron) in equal amounts as type 2 collagen administration to 6-week-old male DBA/1J mice (manufactured by Charles River) The mixed and emulsified solution with a homogenizer was administered intradermally to the tail at 100 µl per animal. Twenty-one days after the administration of type 2 collagen 1, as type 2 collagen administration, a solution obtained by mixing equal amounts of type 2 collagen and Freund's complete adjuvant and emulsifying it with a homogenizer was added to the tail at a rate of 100 µl per animal. It was administered intradermally.

From the day of administration of type 1 collagen 2, a commercial powdered feed CE-2 (manufactured by Nippon Gurea) was added to the mice of the control group, and 0.5% by weight of the joint nutritional composition prepared in Example 1 was added to the mice of the experiment group 1. -2, CE-2, prepared by adding 0.5% by weight of the joint nutritional composition prepared in Example 2 to the mice of the experimental group 2, and 0.5% by weight, to the mice of the experimental group 3, added the joint nutritional composition prepared in Example 3 One CE-2 was taken each. In addition, CE-2 was also taken into the untreated group to which type 2 collagen was not administered.

On the 27th, 30th, and 34th days after administration of type 2 collagen, the degree of onset of arthritis was scored by the following indicators. For one hand or foot of the mouse,

0 points: asymptomatic,

1 point: swelling of one finger, or swelling of the hand (foot) and neck,

2 points: swelling of 1 to 3 fingers, or swelling of the neck of the hand (foot),

3 points: swelling of 3 to 5 fingers + swelling of the hands (foot) and neck,

4 points: swelling of all fingers + swelling of hands (foot) and neck

Scored from 0 to 4 points based on. One mouse was scored as a total score of 4 limbs, that is, 0 to 16 points. Values are expressed as mean ± standard error (N=20).

Table 2 shows the results of the arthritis score.

Arthritis score Additives besides feed (CE-2) 0 days 27 days later 30 days later After 34 days Collagen
Untreated group none 0.00±0.00 0.00±0.00 0.00±0.00 0.00±0.00 Comparative group none 0.00±0.00 6.78±0.32 11.86±0.78 13.57±0.66 Experiment 1 group Joint nutritional composition prepared in Example 1 0.00±0.00 5.35±0.15 9.78±0.32 10.56±0.72 Experiment 2 group Joint nutritional composition prepared in Example 2 0.00±0.00 4.12±0.56 7.59±0.89 8.43±0.52 Experiment 3 group Joint nutritional composition prepared in Example 3 0.00±0.00 3.60±0.21 6.24±0.35 7.22±0.74

As shown in Table 1, the experimental groups 1 to 3 in which the joint nutritional composition of Examples 1 to 3 of the present invention was administered together with feed (CE-2) was a comparative group administered only feed (CE-2). The incidence of arthritis was very low compared to. In particular, the experimental groups 2 and 3 showed remarkably lower levels of arthritis compared to the comparison group.

Claims (4)

Based on the total weight of the composition, methylsulfonylmethane (MSM) 28 to 33% by weight; 8 to 13% by weight of N-acetylglucosamine; 6 to 9% by weight of green lipped mussels; 5 to 7% by weight of mucopolysaccharide; 5 to 8% by weight of omega 3 powder; 3 to 5% by weight of dry yeast; 8 to 12% by weight of hydrolyzed salmon powder; 3 to 7% by weight of fructooligosaccharide; 3 to 7 weight percent glucose; 8 to 12% by weight of crystalline cellulose; And as a companion animal joint nutritional composition comprising a cheese flavor 0.2 to 1% by weight,
The nutrient composition further comprises 3 to 7% by weight of plant fermentation, and the plant fermentation is 1 to 3: 1 of a) Seaside villosa, Nopal, and Lathyrus sativus. ~3: chopping the mixed plant mixture at a weight ratio of 1 to 3 and placing it in a fermentation container; b) adding fig concentrate to the fermentation vessel, inoculating at least one strain of lactic acid bacteria and yeast, and fermenting for 2 weeks to 3 months; c) preparing the fermented product of step b) in a slurry state; And d) drying the slurry of step c) to prepare a powder; Companion animal joint nutritional supplement composition comprising the. delete The method of claim 1,
In step a) further adding 1 to 10 parts by weight of broccoli, 1 to 10 parts by weight of Choseokjam, 1 to 10 parts by weight of capers and 1 to 10 parts by weight of sputum flowers to the fermentation vessel based on 100 parts by weight of the plant mixture Companion animal joint nutrition composition, characterized in that. delete