KR101525629B1 - 항-Ｎｏｔｃｈ3 작동제 항체 및 Ｎｏｔｃｈ3 관련 질환을 치료하는 데에 있어서의 그의 용도 - Google Patents

항-Ｎｏｔｃｈ3 작동제 항체 및 Ｎｏｔｃｈ3 관련 질환을 치료하는 데에 있어서의 그의 용도 Download PDF

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KR101525629B1
KR101525629B1 KR1020097010122A KR20097010122A KR101525629B1 KR 101525629 B1 KR101525629 B1 KR 101525629B1 KR 1020097010122 A KR1020097010122 A KR 1020097010122A KR 20097010122 A KR20097010122 A KR 20097010122A KR 101525629 B1 KR101525629 B1 KR 101525629B1
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KR20090080979A (ko
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캉 리
빈-빙 스티븐 조우
웬쥬안 우
세크 청 풍
산자야 싱
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제넨테크, 인크.
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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KR1020097010122A 2006-10-19 2007-10-18 항-Ｎｏｔｃｈ3 작동제 항체 및 Ｎｏｔｃｈ3 관련 질환을 치료하는 데에 있어서의 그의 용도 Expired - Fee Related KR101525629B1 (ko)

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Application Number Priority Date Filing Date Title
US85286106P 2006-10-19 2006-10-19
US60/852,861 2006-10-19
US87921807P 2007-01-06 2007-01-06
US60/879,218 2007-01-06
PCT/US2007/081797 WO2008051797A2 (en) 2006-10-19 2007-10-18 Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases

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KR1020157004016A Division KR20150023953A (ko) 2006-10-19 2007-10-18 항-Ｎｏｔｃｈ3 작동제 항체 및 Ｎｏｔｃｈ3 관련 질환을 치료하는 데에 있어서의 그의 용도

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KR20090080979A KR20090080979A (ko) 2009-07-27
KR101525629B1 true KR101525629B1 (ko) 2015-06-26

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KR1020097010122A Expired - Fee Related KR101525629B1 (ko) 2006-10-19 2007-10-18 항-Ｎｏｔｃｈ3 작동제 항체 및 Ｎｏｔｃｈ3 관련 질환을 치료하는 데에 있어서의 그의 용도
KR1020157004016A Ceased KR20150023953A (ko) 2006-10-19 2007-10-18 항-Ｎｏｔｃｈ3 작동제 항체 및 Ｎｏｔｃｈ3 관련 질환을 치료하는 데에 있어서의 그의 용도

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US (5) US7994285B2 (enExample)
EP (1) EP2087006B1 (enExample)
JP (1) JP5478254B2 (enExample)
KR (2) KR101525629B1 (enExample)
AR (1) AR063494A1 (enExample)
AU (1) AU2007309229B8 (enExample)
BR (1) BRPI0715989A8 (enExample)
CA (1) CA2666672A1 (enExample)
CL (1) CL2007002987A1 (enExample)
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CR (1) CR10730A (enExample)
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CA2697262A1 (en) * 2007-08-23 2009-02-26 The Trustees Of Columbia University In The City Of New York Compositions of humanized notch fusion proteins and methods of treatment
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ES2532405T3 (es) * 2008-08-22 2015-03-26 The Trustees Of Columbia University In The City Of New York Proteínas de fusión basadas en Notch3 humanas como inhibidores señuelo de la señalización de Notch3
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BR112015010436A2 (pt) * 2012-11-07 2017-08-22 Pfizer Anticorpos anti-notch3 e conjugados anticorpo-fármaco
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US9683039B2 (en) * 2013-03-14 2017-06-20 New York University Notch agonists for the treatment of cancer
JP6641299B2 (ja) * 2014-06-04 2020-02-05 フレッド ハッチンソン キャンサー リサーチ センター Ｎｏｔｃｈ １および／またはＮｏｔｃｈ ２アゴニストを用いた幹細胞の増殖および生着
KR20170029490A (ko) 2014-07-11 2017-03-15 제넨테크, 인크. 노치 경로 억제
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JP7021099B2 (ja) 2016-03-31 2022-02-18 エヌジーエム バイオファーマシューティカルス，インコーポレーテッド 結合タンパク質及びその使用方法
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US8187839B2 (en) 2012-05-29
WO2008051797A3 (en) 2008-07-31
TW200824707A (en) 2008-06-16
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KR20090080979A (ko) 2009-07-27
RU2461569C2 (ru) 2012-09-20
US20140093889A1 (en) 2014-04-03
BRPI0715989A8 (pt) 2018-03-13
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