KR101452518B1 - Ｌｙｎ 키나제 활성의 조절 및 관련된 장애의 치료를 위한방법 및 제제 - Google Patents

Ｌｙｎ 키나제 활성의 조절 및 관련된 장애의 치료를 위한방법 및 제제 Download PDF

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KR101452518B1
KR101452518B1 KR1020087006891A KR20087006891A KR101452518B1 KR 101452518 B1 KR101452518 B1 KR 101452518B1 KR 1020087006891 A KR1020087006891 A KR 1020087006891A KR 20087006891 A KR20087006891 A KR 20087006891A KR 101452518 B1 KR101452518 B1 KR 101452518B1
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KR20080059164A (ko
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앤드류 레우메
마이클 에스. 사포리토
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멜리어 파마슈티칼스 아이, 인코포레이티드
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine

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  • Neurosurgery (AREA)
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  • Reproductive Health (AREA)
KR1020087006891A 2005-08-22 2006-08-22 Ｌｙｎ 키나제 활성의 조절 및 관련된 장애의 치료를 위한방법 및 제제 Active KR101452518B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US70979805P 2005-08-22 2005-08-22
US60/709,798 2005-08-22
US80853306P 2006-05-26 2006-05-26
US60/808,533 2006-05-26
PCT/US2006/032788 WO2007024863A2 (en) 2005-08-22 2006-08-22 Methods and formulations for modulating lyn kinase activity and treating related disorders

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KR1020147016962A Division KR101577554B1 (ko) 2005-08-22 2006-08-22 Ｌｙｎ 키나제 활성의 조절 및 관련된 장애의 치료를 위한 방법 및 제제

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KR101452518B1 true KR101452518B1 (ko) 2014-10-21

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KR1020087006891A Active KR101452518B1 (ko) 2005-08-22 2006-08-22 Ｌｙｎ 키나제 활성의 조절 및 관련된 장애의 치료를 위한방법 및 제제

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US (8) US7776870B2 (enExample)
EP (1) EP1924262B1 (enExample)
JP (1) JP5113752B2 (enExample)
KR (2) KR101577554B1 (enExample)
AT (1) ATE533488T1 (enExample)
AU (1) AU2006283211B2 (enExample)
BR (1) BRPI0615046C1 (enExample)
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CN101668530A (zh) * 2007-07-23 2010-03-10 梅利奥尔探索公司 激活irs-1和akt的方法
US8552184B2 (en) * 2008-07-03 2013-10-08 Melior Pharmaceuticals I, Inc. Compounds and methods for treating disorders related to glucose metabolism
WO2011150300A1 (en) * 2010-05-28 2011-12-01 Melior Pharmaceuticals I, Inc. Prevention of pancreatic beta cell degeneration
CN104271140B (zh) * 2011-12-12 2016-11-23 梅里奥尔医药I公司 I型和ii型糖尿病的治疗
WO2014100636A2 (en) * 2012-12-20 2014-06-26 The Trustees Of Columbia University In The City Of New York Methods of treating atherosclerosis or myeloproliferative neoplasms by administering a lyn kinase activator
JOP20200093A1 (ar) 2015-01-09 2017-06-16 Kyowa Kirin Co Ltd طريقة لإنتاج مشتق ثيازول
JP7182605B2 (ja) * 2017-04-10 2022-12-02 メリオール・ファーマスーティカルズ・ワン・インコーポレイテッド ｌｙｎキナーゼ活性化因子及びＴＲＰＭ８アゴニストを含む組成物及び医薬の製造におけるそれらの使用
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US12070461B2 (en) 2024-08-27
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