KR101429484B1 - 신규한 트리시클릭 안지오텐신 ⅱ 아고니스트 - Google Patents

신규한 트리시클릭 안지오텐신 ⅱ 아고니스트 Download PDF

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KR101429484B1
KR101429484B1 KR1020077025440A KR20077025440A KR101429484B1 KR 101429484 B1 KR101429484 B1 KR 101429484B1 KR 1020077025440 A KR1020077025440 A KR 1020077025440A KR 20077025440 A KR20077025440 A KR 20077025440A KR 101429484 B1 KR101429484 B1 KR 101429484B1
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alkyl
butyl
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KR20080009275A (ko
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마티아스 앨터맨
안데르스 할베르그
지온규 우
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바이코어 파마 아베
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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  • Chemical Kinetics & Catalysis (AREA)
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  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
KR1020077025440A 2005-04-12 2006-04-12 신규한 트리시클릭 안지오텐신 ⅱ 아고니스트 Expired - Fee Related KR101429484B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67025105P 2005-04-12 2005-04-12
US60/670,251 2005-04-12
PCT/GB2006/001319 WO2006109048A1 (en) 2005-04-12 2006-04-12 New tricyclic angiotensin ii agonists

Publications (2)

Publication Number Publication Date
KR20080009275A KR20080009275A (ko) 2008-01-28
KR101429484B1 true KR101429484B1 (ko) 2014-08-13

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Family Applications (1)

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KR1020077025440A Expired - Fee Related KR101429484B1 (ko) 2005-04-12 2006-04-12 신규한 트리시클릭 안지오텐신 ⅱ 아고니스트

Country Status (12)

Country Link
US (1) US8080571B2 (https=)
EP (1) EP1869023B1 (https=)
JP (2) JP5202301B2 (https=)
KR (1) KR101429484B1 (https=)
CN (1) CN101193886B (https=)
AT (1) ATE540947T1 (https=)
AU (1) AU2006235698B2 (https=)
CA (1) CA2604797C (https=)
DK (1) DK1869023T3 (https=)
ES (1) ES2395194T3 (https=)
MX (1) MX2007012634A (https=)
WO (1) WO2006109048A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006235698B2 (en) * 2005-04-12 2012-03-29 Vicore Pharma Ab New tricyclic angiotensin II agonists
TW200840566A (en) * 2006-12-22 2008-10-16 Esteve Labor Dr Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
EP1935886A1 (en) * 2006-12-22 2008-06-25 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
EP2832357A1 (en) 2013-07-29 2015-02-04 Charité - Universitätsmedizin Berlin Selective AT2 receptor agonists for use in treatment of cachexia
EP3820498A1 (en) 2018-06-14 2021-05-19 University College Cork-National University of Ireland Cork Peptide for disease treatment
GB201913603D0 (en) 2019-09-20 2019-11-06 Vicore Pharma Ab New compounds
KR20230004501A (ko) * 2020-03-19 2023-01-06 바이코어 파마 아베 안지오텐신 ⅱ와 관련된 질병, 장애, 또는 병태의 치료 및/또는 예방에 유용한 신규 화합물
GB202007122D0 (en) * 2020-05-14 2020-07-01 Vicore Pharma Ab New process
GB202013721D0 (en) * 2020-09-01 2020-10-14 Vicore Pharma Ab New compounds
CA3247073A1 (en) * 2022-04-06 2025-02-03 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company AT2R AGONIST
CN116355025B (zh) * 2023-04-03 2025-03-28 天津医科大学 一种HO-1i-Pt(IV)配合物和自组装纳米粒的制备方法及其在肿瘤药物中的应用
CN119504723A (zh) * 2023-08-25 2025-02-25 武汉人福创新药物研发中心有限公司 作为at2r激动剂的噻吩磺酰基氨基甲酸酯
TW202508554A (zh) * 2023-08-25 2025-03-01 大陸商武漢人福創新藥物研發中心有限公司 一種作為ａｔ２ｒ促效劑的噻吩磺醯基氨基甲酸酯及其用途
WO2025146172A1 (zh) * 2024-01-03 2025-07-10 武汉人福创新药物研发中心有限公司 一种并环类化合物作为at2r激动剂
WO2025252142A1 (zh) * 2024-06-07 2025-12-11 江苏柯菲平医药股份有限公司 一种血管紧张素ii型2受体激动剂及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046141A1 (en) 2002-11-21 2004-06-03 Vicore Pharma Ab New tricyclic angiotensin ii agonists

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8911854D0 (en) 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IE64514B1 (en) 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
EP0424317A3 (en) * 1989-10-19 1991-09-25 Ciba-Geigy Ag Pyrimidines
DE4023215A1 (de) 1990-07-21 1992-01-23 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung
DE4032522A1 (de) * 1990-10-11 1992-04-16 Schering Ag Neue thienoimidazolderivate, verfahren zu ihrer herstellung und ihre phamazeutische verwendung
IE920175A1 (en) 1991-02-11 1992-08-12 Zeneca Ltd Nitrogen heterocycles
US5177074A (en) * 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5198438A (en) * 1991-05-07 1993-03-30 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
CA2115990A1 (en) * 1991-08-19 1993-03-04 George Albert Boswell Angiotensin ii receptor blocking imidazolinone derivatives
WO1993004045A1 (en) 1991-08-19 1993-03-04 E.I. Du Pont De Nemours And Company Angiotensin ii receptor blocking imidazolinone derivatives
US5312820A (en) * 1992-07-17 1994-05-17 Merck & Co., Inc. Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines
GB9223371D0 (en) 1992-11-06 1992-12-23 Ici Plc Heterocyclic compounds
US5395844A (en) * 1993-06-10 1995-03-07 The Du Pont Merck Pharmaceutical Company Imidazole 5-position substituted angiotensin II antagonists
US5444067A (en) * 1993-08-30 1995-08-22 Merck & Co., Inc. Pharmaceutical treatment methods using angiotensin II receptor agonists bearing a thiophene moiety
EP0882699A4 (en) * 1996-08-06 2001-03-21 Taisho Pharmaceutical Co Ltd AMINO CONNECTIONS AND ANGIOTENSIN IV RECEPTOR AGONISTS
EP0855392A3 (de) * 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
SE9800550D0 (sv) 1998-02-24 1998-02-24 A & Science Invest Ab A pharmaceutical preparation comprising an angiotensin II type 2 receptor agonist, and use thereof
YU78601A (sh) * 1999-05-05 2005-07-19 Aventis Pharma Deutschland Gmbh. 1-(p-tienilbenzil)-imidazoli kao agonisti angiotenzin-(1-7)- receptora, postupak za njihovu proizvodnju, njihova primena i farmaceutski preparati koji ih sadrže
DE10112041A1 (de) * 2001-03-14 2002-09-26 Aventis Pharma Gmbh p-Thienylbenzyl-Amide als Agonisten von Angiotensin-(1-7)-Rezeptoren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CA2449150C (en) * 2001-05-31 2011-07-12 Vicore Pharma Ab Tricyclic compounds useful as angiotensin ii agonists
KR100938817B1 (ko) * 2001-05-31 2010-01-26 바이코어 파마 아베 안지오텐신 ⅱ 작용제로 유용한 삼중고리 화합물
WO2003064414A1 (en) * 2002-01-29 2003-08-07 Vicore Pharma Ab. Tricyclic compounds useful as angiotensin ii agonists
JP4385113B2 (ja) * 2002-09-18 2009-12-16 株式会社ポーラファルマ 新規ビフェニルイミダゾピリジン誘導体及びそれを有効成分とする医薬
AU2003302027A1 (en) 2002-11-21 2004-06-15 Vicore Pharma Ab New tricyclic angiotensin ii agonists
AU2003286251A1 (en) 2002-11-21 2004-06-15 Vicore Pharma Ab New bicyclic angiotensin ii agonists
MXPA05008142A (es) * 2003-01-31 2005-09-30 Sankyo Co Medicamento para la profilaxis y el tratamiento de arteriosclerosis e hipertension.
AU2003219291A1 (en) 2003-03-24 2004-10-18 Vicore Pharma Ab Bicyclic compounds useful as angiotensin ii agonists
AU2006235698B2 (en) * 2005-04-12 2012-03-29 Vicore Pharma Ab New tricyclic angiotensin II agonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046141A1 (en) 2002-11-21 2004-06-03 Vicore Pharma Ab New tricyclic angiotensin ii agonists

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ES2395194T3 (es) 2013-02-11
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JP2008535898A (ja) 2008-09-04
JP5718301B2 (ja) 2015-05-13
US8080571B2 (en) 2011-12-20
EP1869023A1 (en) 2007-12-26
AU2006235698B2 (en) 2012-03-29
DK1869023T3 (da) 2012-04-10
EP1869023B1 (en) 2012-01-11
CN101193886B (zh) 2014-08-27
WO2006109048A1 (en) 2006-10-19
AU2006235698A1 (en) 2006-10-19
CN101193886A (zh) 2008-06-04
CA2604797C (en) 2013-05-28
CA2604797A1 (en) 2006-10-19
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ATE540947T1 (de) 2012-01-15
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KR20080009275A (ko) 2008-01-28

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