KR101420564B1 - TGF-β2 발현을 억제하는 shRNA - Google Patents
TGF-β2 발현을 억제하는 shRNA Download PDFInfo
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- KR101420564B1 KR101420564B1 KR1020130010233A KR20130010233A KR101420564B1 KR 101420564 B1 KR101420564 B1 KR 101420564B1 KR 1020130010233 A KR1020130010233 A KR 1020130010233A KR 20130010233 A KR20130010233 A KR 20130010233A KR 101420564 B1 KR101420564 B1 KR 101420564B1
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- tgf
- shrna
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- adenovirus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
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- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014555484A JP2015506696A (ja) | 2012-01-31 | 2013-01-31 | TGF−β2発現を抑制するshRNA |
CN201380007620.1A CN104245936B (zh) | 2012-01-31 | 2013-01-31 | 用于抑制TGF-β2表达的shRNA |
PCT/KR2013/000791 WO2013115579A1 (ko) | 2012-01-31 | 2013-01-31 | TGF-β2 발현을 억제하는 shRNA |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20120009811 | 2012-01-31 | ||
KR1020120009811 | 2012-01-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20130088792A KR20130088792A (ko) | 2013-08-08 |
KR101420564B1 true KR101420564B1 (ko) | 2014-07-17 |
Family
ID=49215002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020130010233A KR101420564B1 (ko) | 2012-01-31 | 2013-01-30 | TGF-β2 발현을 억제하는 shRNA |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP2015506696A (zh) |
KR (1) | KR101420564B1 (zh) |
CN (1) | CN104245936B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101713407B1 (ko) * | 2014-03-31 | 2017-03-07 | 연세대학교 산학협력단 | 아데노바이러스 감염 및 복제가 가능한 흑색종 세포주 |
WO2015152609A1 (ko) * | 2014-03-31 | 2015-10-08 | 연세대학교 산학협력단 | GM-CSF 유전자; 데코린 유전자; TGF-β2 발현을 억제하는 shRNA; 및 FoxP3 발현을 억제하는 shRNA를 포함하는 항종양 조성물 |
JP6898325B2 (ja) * | 2015-12-08 | 2021-07-07 | ユニバーシティ−インダストリー・ファンデーション・ヨンセイ・ユニバーシティ | GM−CSF遺伝子;Flt3L−TRAIL融合遺伝子;TGF−βの発現を抑制するshRNA;およびHSP発現を抑制するshRNAを含む抗腫瘍組成物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2674210A1 (en) * | 2005-12-30 | 2007-07-12 | Intradigm Corporation | Sirna compositions promoting scar-free wound healing of skin and methods for wound treatment |
WO2011154542A1 (en) * | 2010-06-11 | 2011-12-15 | Artisense Pharma Gmbh | Method for selective oligonucleotide modification |
CN101974529B (zh) * | 2010-09-21 | 2013-04-03 | 南京大学(苏州)高新技术研究院 | 含自由三磷酸基团的TGF-β特异性siRNA及其应用 |
-
2013
- 2013-01-30 KR KR1020130010233A patent/KR101420564B1/ko active IP Right Grant
- 2013-01-31 CN CN201380007620.1A patent/CN104245936B/zh active Active
- 2013-01-31 JP JP2014555484A patent/JP2015506696A/ja active Pending
Non-Patent Citations (3)
Title |
---|
Chenyu Zhang 등. Cancer Research. Vol. 69, No. 3, 페이지 828- 835 (2009.) * |
GenBank Accession Number NM_001135599 (2010.12.19.) * |
GenBank Accession Number NM_009367 (2010.12.29.) * |
Also Published As
Publication number | Publication date |
---|---|
KR20130088792A (ko) | 2013-08-08 |
CN104245936B (zh) | 2016-04-06 |
JP2015506696A (ja) | 2015-03-05 |
CN104245936A (zh) | 2014-12-24 |
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