KR101399178B1 - 선별가능한 특성을 갖는 하이브리드 폴리펩티드 - Google Patents

선별가능한 특성을 갖는 하이브리드 폴리펩티드 Download PDF

Info

Publication number
KR101399178B1
KR101399178B1 KR1020087005846A KR20087005846A KR101399178B1 KR 101399178 B1 KR101399178 B1 KR 101399178B1 KR 1020087005846 A KR1020087005846 A KR 1020087005846A KR 20087005846 A KR20087005846 A KR 20087005846A KR 101399178 B1 KR101399178 B1 KR 101399178B1
Authority
KR
South Korea
Prior art keywords
delete delete
peptide
exendin
amylin
seq
Prior art date
Application number
KR1020087005846A
Other languages
English (en)
Korean (ko)
Other versions
KR20080045185A (ko
Inventor
오딜 에스터 레비
마이클 알. 헨리
캐롤린 엠. 조드카
다이아나 루이스
크리스토퍼 제이. 소아레스
소우미트라 에스. 고쉬
로렌스 드소우자
데이비드 쥐. 파크스
크리스틴 엠. 맥
베로우즈 브루스 포루드
Original Assignee
아스트라제네카 파마수티컬스 엘피
아밀린 파마슈티칼스, 엘엘씨.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/206,903 external-priority patent/US8076288B2/en
Priority claimed from US11/301,744 external-priority patent/US7723471B2/en
Application filed by 아스트라제네카 파마수티컬스 엘피, 아밀린 파마슈티칼스, 엘엘씨. filed Critical 아스트라제네카 파마수티컬스 엘피
Priority claimed from PCT/US2006/031724 external-priority patent/WO2007022123A2/en
Publication of KR20080045185A publication Critical patent/KR20080045185A/ko
Application granted granted Critical
Publication of KR101399178B1 publication Critical patent/KR101399178B1/ko

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020087005846A 2005-08-11 2006-08-11 선별가능한 특성을 갖는 하이브리드 폴리펩티드 KR101399178B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US20166405A 2005-08-11 2005-08-11
US11/201,664 2005-08-11
US11/206,903 US8076288B2 (en) 2004-02-11 2005-08-17 Hybrid polypeptides having glucose lowering activity
US11/206,903 2005-08-17
US11/301,744 2005-12-12
US11/301,744 US7723471B2 (en) 2004-02-11 2005-12-12 Pancreatic polypeptide family motifs, polypeptides and methods comprising the same
PCT/US2006/031724 WO2007022123A2 (en) 2005-08-11 2006-08-11 Hybrid polypeptides with selectable properties

Publications (2)

Publication Number Publication Date
KR20080045185A KR20080045185A (ko) 2008-05-22
KR101399178B1 true KR101399178B1 (ko) 2014-06-18

Family

ID=39662713

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087005846A KR101399178B1 (ko) 2005-08-11 2006-08-11 선별가능한 특성을 갖는 하이브리드 폴리펩티드

Country Status (7)

Country Link
JP (1) JP2009504681A (es)
KR (1) KR101399178B1 (es)
CN (1) CN101296942A (es)
EA (1) EA014647B1 (es)
IL (1) IL188937A0 (es)
MX (1) MX2008002028A (es)
ZA (1) ZA200801138B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102116944B1 (ko) * 2019-09-23 2020-05-29 주식회사 차메디텍 멜라닌 생성 저해 활성을 갖는 신규한 펩타이드 유도체, 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 포함하는 멜라닌 생성 저해용 조성물

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120071401A1 (en) * 2009-04-10 2012-03-22 Amylin Pharamaceuticals, Inc. Amylin agonist compounds for estrogen-deficient mammals
RU2012126101A (ru) * 2009-11-23 2013-12-27 АМИЛИН ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи,США Полипептидный конъюгат
GB201001333D0 (en) * 2010-01-27 2010-03-17 Imp Innovations Ltd Novel compounds and their effects on feeding behaviour
CN107129538B (zh) * 2010-04-27 2021-07-16 西兰制药公司 Glp-1受体激动剂和胃泌素的肽缀合物及其用途
RU2552221C2 (ru) * 2010-07-15 2015-06-10 Общество С Ограниченной Ответственностью "Научно-Производственная Фирма "Материа Медика Холдинг" Способ лечения ожирения и сопутствующих метаболических расстройств и лекарственное средство для лечения ожирения и сопутствующих метаболических расстройств
JP2014521594A (ja) * 2011-05-25 2014-08-28 アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー 長持続期間デュアルホルモンコンジュゲート
TWI674270B (zh) * 2012-12-11 2019-10-11 英商梅迪繆思有限公司 用於治療肥胖之升糖素與glp-1共促效劑
JP2017532292A (ja) * 2014-08-11 2017-11-02 オルバニー メディカル カレッジ ミリストイル化レプチン関連ペプチド及びその使用
KR101689803B1 (ko) * 2015-11-17 2016-12-27 고려대학교 산학협력단 아펠린-16을 유효성분으로 함유하는 당뇨 또는 비만의 예방 또는 치료용 조성물
US11034745B2 (en) * 2016-01-04 2021-06-15 Adepthera Llc Superagonist polypeptide analogs of adrenomedullin and intermedin peptide hormones
JP6889432B2 (ja) * 2016-04-28 2021-06-18 学校法人甲南学園 樹脂固定ペプチド
SG10202101243YA (en) * 2016-09-02 2021-03-30 Univ Illinois Kif13b-derived peptide and method of inhibiting angiogenesis
WO2019054460A1 (ja) * 2017-09-13 2019-03-21 株式会社ジーンテクノサイエンス 抗ｒａｍｐ２抗体
TWI847981B (zh) * 2018-04-25 2024-07-11 比利時商健生藥品公司 類升糖素肽1 (glp-1)融合肽偶合環狀酪酪肽接合物及其用途
US10875902B2 (en) 2018-04-25 2020-12-29 Janssen Pharmaceutica Nv Glucagon like peptide 1 (GLP-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof
CN117603364A (zh) * 2022-09-30 2024-02-27 广西医科大学附属肿瘤医院 一类GLP-1/glucagon/Y2受体三重激动剂及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020885A1 (en) 1996-11-13 1998-05-22 University Of Cincinnati Analogs of peptide yy and uses thereof
US20040115135A1 (en) 2002-12-17 2004-06-17 Quay Steven C. Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity
WO2004089279A2 (en) * 2003-04-08 2004-10-21 Yeda Research And Development Co. Ltd. Long-acting derivatives of pyy agonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739106A (en) * 1995-06-07 1998-04-14 Rink; Timothy J. Appetite regulating compositions
EP0910578A2 (en) * 1996-01-19 1999-04-28 The Board Of Regents, The University Of Texas System Recombinant expression of proteins from secretory cell lines
NZ514145A (en) * 1996-12-20 2003-08-29 Amgen Inc OB fusion protein compositions and methods
US6506724B1 (en) * 1999-06-01 2003-01-14 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus
US6528486B1 (en) * 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
CA2396157A1 (en) * 2000-01-10 2001-07-19 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for modulation of triglyceride levels and treatment of dyslipidemia
CZ306180B6 (cs) * 2000-12-07 2016-09-14 Eli Lilly And Company GLP-1 fúzní proteiny
DE60228972D1 (de) * 2001-07-31 2008-10-30 Us Gov Health & Human Serv Glp 1 exendin 4 peptidanaloga und deren verwendungen
US7192922B2 (en) * 2002-11-19 2007-03-20 Allegheny-Singer Research Institute Method of treating left ventricular dysfunction
AU2003297356A1 (en) * 2002-12-17 2004-07-14 Amylin Pharmaceuticals, Inc. Prevention and treatment of cardiac arrhythmias
WO2005077072A2 (en) * 2004-02-11 2005-08-25 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020885A1 (en) 1996-11-13 1998-05-22 University Of Cincinnati Analogs of peptide yy and uses thereof
US20040115135A1 (en) 2002-12-17 2004-06-17 Quay Steven C. Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity
WO2004089279A2 (en) * 2003-04-08 2004-10-21 Yeda Research And Development Co. Ltd. Long-acting derivatives of pyy agonists

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102116944B1 (ko) * 2019-09-23 2020-05-29 주식회사 차메디텍 멜라닌 생성 저해 활성을 갖는 신규한 펩타이드 유도체, 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 포함하는 멜라닌 생성 저해용 조성물

Also Published As

Publication number Publication date
MX2008002028A (es) 2008-03-27
KR20080045185A (ko) 2008-05-22
IL188937A0 (en) 2008-04-13
CN101296942A (zh) 2008-10-29
JP2009504681A (ja) 2009-02-05
EA014647B1 (ru) 2010-12-30
ZA200801138B (en) 2008-12-31
EA200800548A1 (ru) 2008-08-29

Similar Documents

Publication Publication Date Title
KR101399178B1 (ko) 선별가능한 특성을 갖는 하이브리드 폴리펩티드
EP2330124B1 (en) Hybrid polypeptides with selectable properties
US8895498B2 (en) GIP and exendin hybrid polypeptides
US9453063B2 (en) Hybrid polypeptides with selectable properties
JP5399244B2 (ja) 選択可能な特性を持つｄｐｐ−ｉｖ耐性ｇｉｐハイブリッドポリペプチド
US8497240B2 (en) DPP-IV resistant GIP hybrid polypeptides with selectable properties
JP5580784B2 (ja) 選択可能な特性を有するハイブリッドポリペプチド
KR20070115947A (ko) 선택가능한 특성들을 가지는 ｇｉｐ 유사체 및 하이브리드폴리펩타이드
EP2330125A2 (en) Hybrid polypeptides with selectable properties
ES2537062T3 (es) Polipéptidos híbridos con propiedades seleccionables
KR20070016117A (ko) 선택가능한 특성을 갖는 하이브리드 폴리펩티드

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
N231 Notification of change of applicant
E90F Notification of reason for final refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20170420

Year of fee payment: 4

FPAY Annual fee payment

Payment date: 20180417

Year of fee payment: 5

LAPS Lapse due to unpaid annual fee