KR101378346B1 - Apparatus for manufacturing biomarker coating strip - Google Patents

Apparatus for manufacturing biomarker coating strip Download PDF

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Publication number
KR101378346B1
KR101378346B1 KR1020140007532A KR20140007532A KR101378346B1 KR 101378346 B1 KR101378346 B1 KR 101378346B1 KR 1020140007532 A KR1020140007532 A KR 1020140007532A KR 20140007532 A KR20140007532 A KR 20140007532A KR 101378346 B1 KR101378346 B1 KR 101378346B1
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KR
South Korea
Prior art keywords
sheet
protein
unit
sample
manufacturing apparatus
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KR1020140007532A
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Korean (ko)
Inventor
한효진
박복단
김규식
Original Assignee
하노스 주식회사
한효진
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Priority to KR1020140007532A priority Critical patent/KR101378346B1/en
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Publication of KR101378346B1 publication Critical patent/KR101378346B1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7756—Sensor type
    • G01N2021/7759—Dipstick; Test strip

Abstract

The present invention relates to a biomarker coating strip manufacturing apparatus, and to a manufacturing apparatus for precisely marking a plurality of protein samples in sheet form on a sheet of paper.
To this end, the body part 10 and the protein supply part 20 provided inside the upper end of the body part 1 and the sheet supply part 30 supplying sheet paper for marking the protein sample supplied from the protein supply part 20. And a nozzle unit 40 for supplying the protein sample supplied from the protein supply unit 20 to the sheet paper supplied from the sheet supply unit 30, the sheet conveying unit 50 for conveying the sheet paper, and the sheet conveying unit 50. Is provided between the sheet recovery section 60 and the sheet supply section 30 and the sheet recovery section 60 for recovering the completed sheet is passed whether the protein sample marked on the sheet is passed It is to provide a biomarker coating strip manufacturing apparatus consisting of a vision inspection unit 70 for inspection.

Description

Biomarker coating strip manufacturing equipment {APPARATUS FOR MANUFACTURING BIOMARKER COATING STRIP}

The present invention relates to a biomarker coating strip manufacturing apparatus, and relates to a manufacturing apparatus for precisely marking a plurality of protein samples in strip form on sheet paper.

In general, a biomarker is used to test a biological test such as an allergy or the like, or to test an antigen. The biomarker is used by marking a membrane (hereinafter, referred to as an 'inspection sheet').

This marking method also has a variety of methods, the representative of which may be a method of marking the sample in the form of a dot, and a method of marking in the shape of a strip of a line shape.

In order to mark the sheet paper in the shape of a strip as described above, a strip manufacturing apparatus should be used, and since the liquid protein sample must be supplied at a constant interval on the sheet to form a plurality of strips, a precise quantity must be supplied. The reality is that work is required.

This is because a normal 24Ch, that is, 24 strips are marked on a sheet paper maintaining a constant specification, there is a problem that a defect occurs because of interference or overlap between each strip.

However, due to the increase in various samples such as allergy, more bio-marker coating strip manufacturing apparatus which is more stable and faster at the time when the development of sheet paper marked with a larger number of strips is required for molecular diagnosis. Necessity is emerging.

Korean Unexamined Patent Publication No. 10-2006-0112939 (Diagnostic Strip Using Beads and Manufacturing Method thereof, published 2006, November, 02) Republic of Korea Patent Publication No. 10-2005-0114100 (Colon Cancer Diagnostic Kit, published on December 05, 2005) Republic of Korea Patent Publication No. 10-2013-0041255 (analyte cartridge, published on April 24, 2013) Republic of Korea Patent Publication No. 10-2013-002912 (Reagent Cartridge, published March 21, 2013)

In order to achieve the above object of the present invention, there is provided a manufacturing apparatus capable of manufacturing a biomarker coating strip capable of quickly marking a large number of biomarker strips on sheet paper.

It is another object of the present invention to provide a manufacturing apparatus capable of marking a plurality of biomarker coating strips on a sheet of paper precisely.

In the manufacturing apparatus capable of producing a biomarker coating strip on the inspection sheet for achieving the object of the present invention, the working chamber 11 and the working chamber 11 which is a working space for marking a protein sample on the sheet The body portion 10 is composed of an upper chamber 12 formed on the upper side of the support chamber 13 formed on the lower end of the working chamber 11 and the protein supply unit provided inside the upper chamber 12 ( 20) and a sheet paper supply unit 30 which is located inside the working chamber 11 and supplies a sheet of paper for marking a protein sample supplied from the protein supply unit 20 and a sheet paper supply unit which is located inside the working chamber 11. And a conveying rail 51 disposed in the transverse direction of the nozzle part 40 and the working chamber 11 for marking the protein sample supplied from the protein supply part 20 in a strip form on the sheet supplied from the 30. On the conveying rail 51 It is composed of a conveying tray 52 which is coupled to be movable, and is located at the end of the sheet conveying unit 50 for conveying the sheet paper and the inner sheet conveying unit 50 of the working chamber 11, the work sheet recovery is completed Biomarker which is provided between the sheet collecting portion 60 and the sheet supplying portion 30 and the sheet collecting portion 60 to the vision inspection unit 70 for checking the acceptance of the protein sample marked on the sheet Provided is a coating strip manufacturing apparatus.

In addition, a drying unit is disposed adjacent to the vision inspection unit 70 to dry the biomarker strip marked on the sheet of paper completed by the nozzle unit 40, and the body unit 10 is a working chamber. A vision inspection cabinet 14 for partitioning one side of the upper chamber 12 and the vertical chamber 11 and accommodating the vision inspection unit 70 is further provided.

In addition, the protein supply unit 20 is a syringe 21 having a receiving portion so as to store the protein supplied to the nozzle unit 40 and a sample inlet for supplying a protein sample to the syringe 21 ( 22) and the solenoid valve for controlling the operation of the sample inlet 23 and the sample inlet 22 and the sample outlet 23 positioned adjacent to the sample inlet 22 and for transferring the protein sample to the syringe 21. And a protein supply unit 25 having a control device therein, wherein the syringe 21 is provided at the front of the protein supply unit 25 and adjacent to the syringe 21. A sample inlet 22 and a sample outlet 23 are respectively disposed, and the solenoid valve 24 is positioned on the front surface of the protein supply unit 25 adjacent to the sample inlet 22 and the sample outlet 23. The sheet paper supply unit 30 is a catch for shifting the sheet paper A transfer cartridge 33 and the transfer cartridge for coupling the carrier arm 31 to the guide rod 32 and the guide rod 32 to which the rear arm 31 and the carrier arm 31 can move; 33 is composed of a drive window (34) to move along the guide rod (32).

In addition, a vacuum suction unit 31a is further provided at each end of the carrier arm 31 to absorb and transport corners of the sheet paper, and the nozzle unit 40 is a linear actuator 41 and the linear actuator. The horizontal bar 42 is coupled to the elevating operation 41 and the manifold 43 is coupled to one side of the horizontal bar 42, the lifting rail 41a is provided on the side of the linear actuator 41 It is provided, and the rail roller 42a provided in the horizontal bar 42 to the lifting rail (41a) is coupled so that the horizontal bar 42 is moved up and down along the lifting rail (41a).

In addition, a plurality of nozzles 43a are coupled to the manifold 43 in a direction perpendicular to the side of the manifold 43, and a sample outlet port 23 and a transfer tube at one end of the nozzle 43a. It is coupled to supply a protein sample to the nozzle (43a) to be able to mark on the sheet, the manifold (43) provided in the nozzle 43a is provided within eight.

In addition, the upper surface of the transfer tray 52 is further provided with a vacuum suction port 52a for binding the sheet paper to be stacked to fix the position of the sheet during work, the nozzle unit 40 is 1 When marking a plurality of protein strips on two sheets of paper, a plurality of them are arranged in the working chamber 11 to reduce defect rates such as overlap and interference, and separated into protein sample groups having similar viscosity to the protein samples, and are supplied through the nozzles. In order to control the time and the moving speed of the feed tray, it is possible to better achieve the object of the present invention by providing a biomarker coated strip manufacturing apparatus, characterized in that each nozzle unit 40 is operated in turn. .

By providing the biomarker coating strip manufacturing apparatus of the present invention, it is possible to quickly mark a large number of biomarker strips on the sheet so that the work process can proceed quickly, and a plurality of biomarker coating strips by supplying a quantitative protein sample There is an effect that can be accurately marked on the sheet.

1 is a perspective view of the present invention.
2 is a front view of the present invention.
3 is a perspective view of the protein supply unit 20 of the present invention.
4 is a perspective view of the sheet paper supply unit 30 of the present invention.
5 is a perspective view of the nozzle unit 40 of the present invention.
6 is a perspective view of the sheet conveying unit 50 of the present invention.
7 is an exemplary diagram for illustrating a sheet marking operation of the present invention.

Hereinafter will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily implement the biomarker coating strip manufacturing apparatus of the present invention.

1 is a perspective view of the present invention, Figure 2 is a front view of the present invention.

1 and 2, the biomarker coating strip manufacturing apparatus of the present invention is the body portion 10 and the protein supply portion 20 provided inside the upper end of the body portion 1, and the protein Nozzle for supplying a sheet of protein supplied from the protein supply unit 20 to the sheet paper supply unit 30 for supplying the sheet paper for marking the protein sample supplied from the supply unit 20 and the sheet paper supplied from the sheet supply unit 30 to the sheet paper The sheet 40 and the sheet conveying unit 50 for transferring the sheet paper and the end portion of the sheet conveying unit 50 is provided, the sheet collecting portion 60 and the sheet supply unit 30 for recovering the finished sheet paper and It is provided between the sheet collecting portion 60 is composed of a vision inspection unit 70 for inspecting the acceptance of the protein sample marked on the sheet, and disposed adjacent to the vision inspection unit 70 in the nozzle unit 40 of The operation is completed the sheet surface is coated with a bio-marker drying unit (not shown) for the now dry strip marking is further provided.

The body portion 10 of the working chamber 11 and the upper chamber 12 and the working chamber 11 formed on the upper side of the working chamber 11, which is a space for marking a protein sample on a sheet of paper. Comprising a base portion 13 is formed in the lower end, and partitions one side of the working chamber 11 and the upper chamber 12 in the vertical direction, the vision inspection cabinet 14 for installing the vision inspection unit 70 This is further provided.

In addition, the upper portion of the body portion 10 is further provided with a cover 15 that can be opened and closed in the upward direction.

Here, the inside of the working chamber 11 is provided with a sheet supply unit 30 for supplying sheet paper, a nozzle unit 40 for marking a protein sample on the supplied sheet paper and a transfer rail 50 for transporting the sheet paper In addition, the sheet recovery portion 60 for recovering the sheet at one end adjacent to the conveying rail 50 is further provided.

In addition, the vision inspection unit 70 is provided between the sheet supply unit 30 and the sheet recovery unit 60.

At this time, the vision inspection unit 70 is a device for reading and inspecting a normal image, which is a known technique that can be known by anyone with ordinary knowledge, and a detailed description thereof will be omitted.

The vision inspection unit 70 is located inside the vision inspection cabinet 14 which is partitioned in a vertical direction to one side of the working chamber 11, the working chamber 12, and the upper chamber 12, and performs vision inspection. The pin point of the lens for the downward direction, that is, is installed to face the upper side of the transfer rail.

One side of the upper chamber 12 formed above the working chamber 11 is provided with a protein supply unit 20 for supplying a protein sample.

Here, after partitioning the working chamber 11 and the upper chamber 12, the reason that the protein supply unit 20 for supplying the sample protein is located separately in the upper chamber 12, the plurality of sample proteins having different properties In order to prevent contamination by heterologous proteins during the marking operation of the working chamber 11, the proteins are stored separately, and the sample protein in a liquid state having a high viscosity is placed higher than the nozzle portion 40 to provide gravity. It is also intended to be better moved by.

As described above, each heterologous protein is stored separately to prevent the sample from being contaminated, and when the protein strip is marked on the sheet paper, the sample protein is transferred to the nozzle unit 40 provided in the working chamber 11 to transfer the sheet paper. Will be marking protein strips.

The sheet supply unit 30 is for supplying the sheet paper for marking the protein strip to the sheet conveying unit (50).

Here, the sheet conveying unit 50 is composed of a conveying rail 51 and a conveying tray 52 provided on the conveying rail 51.

The sheet supply unit 30 as described above is moved to the transfer tray 52 provided on the transfer rail 51 disposed in the transverse direction at the center of the working chamber 11 after mounting the sheet, the transfer tray 52 The sheet paper is supplied onto the sheet.

At this time, each of the corners of the sheet supply unit 30 is provided with a suction port (31a: see Figure 4) for the vacuum adsorption to move the sheet in the transfer tray 51 by vacuum suction of each corner of the sheet of paper. do.

As described above, the transfer tray 52 positioned on the transfer rail 51 moves along the transfer rail 51. At this time, the transfer tray 52 is to be transferred using air or a transmission.

As described above, the sheet paper conveyed by the transfer tray 52 moves to the nozzle unit 40 to mark the protein sample supplied from the nozzle unit 40 in a strip form on the sheet, and then adjacent to the nozzle unit 40. After the vision inspection is performed by the vision inspection unit 70, the sheet inspection unit 70 moves to the sheet collection unit 60 located next to the vision inspection unit 70 to recover the marked sheet.

At this time, a drying unit (not shown) is further provided on the upper side of the transfer rail 51 adjacent to the vision inspection unit 70 to dry the protein sample of the sheet paper marked at the nozzle unit 40.

The drying unit supplies air on a sheet of paper to quickly dry the marked protein strips.

This is to prevent defects due to overlap and interference, which may occur when marking a plurality of protein strips on one sheet of paper.

3 is a perspective view of the protein supply unit 20 of the present invention.

Referring to FIG. 3, the protein supply unit 20 will be described in detail. The protein supply unit 20 provided in the upper chamber 12 of the body portion 10 to supply a protein sample is supplied to the nozzle unit 40. A syringe 21 capable of storing one serving of a protein sample, a sample inlet 22 for supplying a protein sample to the syringe 21, and a sample outlet 23 positioned adjacent to the sample inlet 22. And a solenoid valve 24 for transferring a protein sample to the syringe 21 through the operation control of the sample inlet 22 and the sample outlet 23, and a control device (not shown) inside. And a protein supply unit 25 for operating (21).

The syringe 21 is provided with an accommodating part in a normal inner side, and used to store or supply a liquid reagent in a syringe shape provided with an inner cylinder boom in the accommodating part. Anyone with ordinary knowledge of the field can know it, so it should be omitted.

The syringe 21 as described above is provided in front of the protein supply unit 25, the protein supply unit 25 controls the movement of the cylinder boom of the syringe 21.

The cylinder boom can be lifted and lowered by a driving device (not shown) provided inside the protein supply unit 25.

Here, the driving device may be an electric device using electricity or an air device using air.

The sample inlet 22 and the sample outlet 23 are respectively disposed adjacent to an inlet (not shown) of the syringe 21 at one side of the upper front portion of the protein supply unit 25 having the syringe 21. .

Here, the sample inlet 22 and the sample outlet 23 are controlled by the solenoid valve 24 provided on the upper side of the protein supply unit 25, the solenoid valve 24 is a conventional 3-WAY valve It is applied to control the opening and closing of the sample inlet 22 and the sample outlet (23).

In more detail, when the sample is supplied to the syringe 21, the sample inlet 22 is kept open to supply the protein sample into the syringe 21, and the protein accommodated in the syringe 21. When the sample is taken out, the sample outlet 23 is opened, and the sample inlet 22 is closed to take out the protein sample through the sample outlet 23.

When the protein sample is supplied to the syringe 21 through the sample inlet 22, the protein sample may be supplied from a protein sample storage tank (not shown) separately provided in the upper chamber 12.

The introduction and withdrawal amount of the protein sample may be controlled by controlling the operating time of the syringe 21 and the solenoid valve 24 through a control device (not shown) provided inside the protein supply unit 25. .

As described above, the protein sample drawn out through the sample outlet 23 is transferred to the nozzle unit 40 through a transfer tube 16 (see FIG. 1), which is a normal transfer line.

Herein, the transfer tube is known to anyone having ordinary knowledge, so a detailed description thereof will be omitted.

4 is a perspective view of the sheet paper supply unit 30 of the present invention.

Referring to Figure 4 in detail with respect to the sheet supply unit 30 of the present invention, the sheet supply unit 30 for supplying a sheet of paper for marking a protein sample to the sheet conveying unit 50 is a carrier arm for shifting the sheet (31) and the guide rod 32 which the carrier arm 31 can move, and the transfer cartridge 33 and the transfer cartridge 33 which can couple the carrier arm 31 to the guide rod 32 It consists of a drive device 34 to move along the guide rod (32).

Here, each end of the carrier arm 31 is provided with a vacuum adsorber 31a to absorb and transport each corner of the sheet paper.

The sheet supply unit 30 configured as described above has the same configuration as the sheet recovery unit 60, and binds the sheet using the vacuum absorber 31 a of the carrier arm 31, and then moves to the rear portion along the guide rod 32. The carrier arm 31 is to be transferred.

After the sheet paper is transferred as described above, the operation of the vacuum suction unit 31a is controlled to load the sheet paper on the transfer tray 52 positioned at the rear portion of the sheet transfer unit 30.

This is the same configuration as the sheet collecting portion 60, the sheet collecting portion 60 is operated in the opposite direction to the sheet feeding portion 30 to recover the sheet from the transfer tray 52.

5 is a perspective view of the nozzle unit 40 of the present invention.

Referring to FIG. 5 in detail, the nozzle unit 40 capable of supplying a protein sample to the sheet paper supplied to the sheet conveying unit 50 through the sheet supplying unit 30 and marking the strip in a strip shape is a linear actuator 41. ) And a horizontal bar 42 coupled to the linear actuator 41 to move up and down, and a manifold 43 coupled to one side of the horizontal bar 42.

Here, the linear actuator 41 is disposed adjacent to the inner conveying rail 51 of the working chamber 11, and the linear actuator 41 is disposed on one side of the horizontal bar 42 which is coupled to move up and down on the linear actuator 41. A manifold 43 is arranged spaced apart from 41.

At this time, the manifold 43 is positioned to correspond to the transfer tray 52 coupled to the transfer rail 51, it is possible to mark the protein sample on the sheet paper bound on the transfer tray 52.

A lifting rail 41a is provided on the side surface of the linear actuator 41 as described above, and a rail roller 42a provided at the end of the horizontal bar 42 is coupled to the lifting rail 41a, thereby lifting the lifting rail 41a. The rail roller 42a is coupled to the lifting operation along the).

By the above configuration, the horizontal bar 42 is to be moved up and down, and the manifold 43 coupled to the end of the horizontal bar 42 is to be moved up and down.

At this time, the manifold 43 is provided with a plurality of nozzles (43a), the nozzle 43a is coupled in a vertical direction to the side of the manifold 43, the sample of the protein supply unit 20 at one end Combined with the outlet 23 and the transfer tube 16, which is a transfer line, the protein sample may be supplied to the nozzle 43a to mark the sheet.

A plurality of such nozzles 43a are disposed on one manifold 43, but in the present invention, it is preferable that the nozzles 43a be provided within eight.

The protein sample is supplied to the nozzle 43a disposed on the manifold 43 as described above, and the horizontal bar 42 is downwardly coupled to the transfer tray 52 transferred along the transfer rail 51. Protein samples are marked in strip form on the sheet.

6 is a perspective view of the sheet conveying unit 50 of the present invention.

Referring to Figure 6, in detail, the sheet conveying unit 50 to perform the operation while continuously performing the supplied sheet paper nozzle unit 40, the vision inspection unit 70 and the drying unit (not shown) is The transfer rail 51 is disposed inside the working chamber 11 and the transfer tray 52 disposed on the transfer rail 51 and transferred.

In addition, the upper side of the transfer tray 52 is provided with a plurality of vacuum suction holes 52a to bind the sheet paper to be stacked on the upper side.

This is to prevent the position shift from occurring while the sheet paper loaded on the upper side goes through the continuous operation.

Here, the transfer tray 52 is to be transferred along the transfer rail 51 using air or an electric motor.

The sheet conveying unit 50 as described above is disposed in the transverse direction inside the working chamber 11, which is disposed as much as the distance from the sheet supplying unit 30 to the sheet collecting portion 60.

Hereinafter, an operation of marking a protein sample on sheet paper will be described with reference to the drawings.

7 is an exemplary diagram for illustrating a sheet marking operation of the present invention.

In detail, referring to FIG. 7, after the sheet for work is supplied on the transfer tray 52, a plurality of nozzle units 40 are disposed in the working chamber 11 along the transfer rail 51. Will be transferred to.

 As described above, when the transfer tray 52 is transferred to the place where the nozzle unit 40 is located, some of the nozzle units 40 of the plurality of nozzle units 40 operate to mark the protein sample in a strip shape. do.

At this time, the plurality of nozzles 40 are operated at different times.

For example, when four nozzle units 40 having eight nozzles 43a are arranged, the first strip marking operation is performed by operating only the nozzle unit located at the first seat and the nozzle unit located at the third seat. After the transfer tray 52 is transferred back to its original position, the secondary strip marking operation is performed through the nozzle unit positioned at the second position and the nozzle unit disposed at the fourth position.

The reason why the strip marking operation is performed alternately as described above is to reduce the failure rate due to overlap and interference when marking a plurality of protein strips on one sheet of paper.

Each of the plurality of nozzles 40 arranges the separation distance between the linear actuator 41 and the manifold 43 differently so that another nozzle part can compensate for the empty space of each nozzle part.

For example, after the operation of the nozzle portion disposed in the first position and the nozzle portion disposed in the third position, the nozzle portion disposed in the second position and the fourth position in the space between the strips marked on the sheet by each nozzle portion The strip marking operation is performed by the nozzle unit disposed in place.

In addition, by controlling each nozzle unit individually by a control device provided in the plurality of nozzle units as described above, by separating the protein sample group with similar viscosity for each protein sample, supply time through the nozzle and the moving speed of the transfer tray, etc. In this way, a plurality of strips are marked on the sheet.

By the above method, a plurality of strips can be marked on one sheet of paper.

10: body portion 11: working chamber
12: upper chamber 13: support portion
14: vision inspection cabinet 20: protein supply
21: syringe 22: sample inlet
23: sample outlet 24: solenoid valve
25: protein supply unit 30: sheet supply unit
31: carrier arm 32: guide rod
33: transfer cartridge 34: drive device
40 nozzle part 41 linear actuator
42: horizontal bar 43: manifold
50: sheet conveying unit 51: transfer rail
52: transfer tray 60: sheet recovery portion
70: vision inspection

Claims (11)

In the manufacturing apparatus capable of manufacturing a biomarker coating strip on the inspection sheet,
The working chamber 11, which is a working space for marking protein samples on a sheet, the upper chamber 12 formed above the working chamber 11, and the supporting part 13 formed at the lower end of the working chamber 11. Body portion 10 consisting of; and
A protein supply unit 20 provided inside the upper chamber 12; and
A sheet paper supply unit 30 positioned inside the working chamber 11 and supplying sheet paper for marking a protein sample supplied from the protein supply unit 20; and
Located in the working chamber 11 and the nozzle unit 40 for marking the protein sample supplied from the protein supply unit 20 in the form of a strip on the sheet supplied from the sheet supply unit 30; and
It consists of a conveying rail 51 disposed in the transverse direction of the inner side of the working chamber 11 and a conveying tray 52 coupled to be movable on the conveying rail 51, the sheet conveying unit 50 for conveying sheet paper );Wow
It is located at the end of the inner sheet conveying unit 50 of the working chamber 11, the sheet sheet recovery unit 60 for recovering the completed sheet paper; and
Bio-marker coating strip manufacturing apparatus, characterized in that configured between the sheet supplying portion 30 and the sheet collecting portion 60 is provided with a vision inspection unit 70 for inspecting the acceptance of the protein sample marked on the sheet.
The method according to claim 1,
The biomarker coating strip manufacturing apparatus, characterized in that the drying unit for drying the biomarker strip marked on the sheet paper is completed by the nozzle unit 40 is disposed adjacent to the vision inspection unit 70 is completed.
The method according to claim 1,
The body portion 10 partitions one side of the working chamber 11 and the upper chamber 12 in a vertical direction, and further includes a vision inspection cabinet 14 for accommodating the vision inspection unit 70. Bio marker coating strip manufacturing apparatus.
The method according to claim 1,
The protein supply unit 20 is a syringe 21 having a receiving unit so as to store a single protein supplied to the nozzle unit 40 and a sample inlet 22 for supplying a protein sample to the syringe 21. And a solenoid valve 24 for controlling the operation of the sample inlet 23 and the sample inlet 22 and the sample outlet 23 which are located adjacent to the sample inlet 22, and for transferring the protein sample to the syringe 21. ) And a protein supply unit 25 having a control device therein, wherein the syringe 21 is provided in the front portion of the protein supply unit 25, and the sample inlet is adjacent to the syringe 21. (22) and the sample outlet (23) is disposed, respectively, characterized in that the solenoid valve 24 is located on the front surface of the protein supply unit 25 adjacent to the sample inlet (22) and the sample outlet (23). Biomarker coating strip manufacturing apparatus.
The method according to claim 1,
The sheet supply unit 30 may move the carrier arm 31 to the carrier arm 31 for shifting the sheet, the guide rod 32 to which the carrier arm 31 can move, and the guide rod 32. Bio-marker coating strip manufacturing apparatus, characterized in that consisting of a transfer cartridge 33 and the drive cartridge (34) to move along the guide rod (32) coupled to the transfer cartridge (33).
6. The method of claim 5,
Each end of the carrier arm (31) is further provided with a vacuum absorber (31a) is a biomarker coating strip manufacturing apparatus, characterized in that for adsorbing and transporting each corner of the sheet.
The method according to claim 1,
The nozzle unit 40 is composed of a linear actuator 41 and a horizontal bar 42 coupled to the lifting and lowering operation of the linear actuator 41 and a manifold 43 coupled to one side of the horizontal bar 42. The side of the linear actuator 41 is provided with a lifting rail 41a, a rail roller 42a provided on the horizontal bar 42 is coupled to the lifting rail 41a to move horizontally along the lifting rail 41a. Bio marker coating strip manufacturing apparatus, characterized in that the bar (42) to be moved up and down.
8. The method of claim 7,
A plurality of nozzles 43a are coupled to the manifold 43 in a direction perpendicular to the side of the manifold 43, and coupled to a sample outlet port 23 and a transfer tube at one end of the nozzle 43a. The biomarker coating strip manufacturing apparatus, characterized in that the protein sample can be supplied to the nozzle (43a) to be marked on the sheet.
9. The method of claim 8,
Biomarker coating strip manufacturing apparatus characterized in that provided in the manifold (43), the nozzle (43a) is provided within eight.
The method according to claim 1,
Bio-marker coating strip manufacturing apparatus, characterized in that the upper surface of the transfer tray 52 is further provided with a vacuum suction port (52a) for binding the sheet paper to be loaded to fix the position of the sheet during operation.
11. The method according to any one of claims 1 to 10,
The nozzle part 40 is disposed in the working chamber 11 in order to reduce the defect rate such as overlap and interference when marking a plurality of protein strips on one sheet paper, the protein sample having a similar viscosity of the protein sample Bio-marker coating strip manufacturing apparatus, characterized in that to operate each nozzle unit 40 in order to separate into a group to control the supply time and the moving speed of the transfer tray through the nozzle.
KR1020140007532A 2014-01-22 2014-01-22 Apparatus for manufacturing biomarker coating strip KR101378346B1 (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910004157B1 (en) * 1987-02-17 1991-06-22 Enamel Products & Plating Co Strip inspecting apparatus and associated method
KR100582202B1 (en) * 2003-10-13 2006-05-23 엘지.필립스 엘시디 주식회사 Fabrication apparatus and method of thin film transistor array substrate
KR101030640B1 (en) * 2009-02-13 2011-04-20 김보성 Manufacturing apparatus for allergy test strip
KR101101199B1 (en) * 2011-07-14 2012-01-04 영동제약 주식회사 Strip supply device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910004157B1 (en) * 1987-02-17 1991-06-22 Enamel Products & Plating Co Strip inspecting apparatus and associated method
KR100582202B1 (en) * 2003-10-13 2006-05-23 엘지.필립스 엘시디 주식회사 Fabrication apparatus and method of thin film transistor array substrate
KR101030640B1 (en) * 2009-02-13 2011-04-20 김보성 Manufacturing apparatus for allergy test strip
KR101101199B1 (en) * 2011-07-14 2012-01-04 영동제약 주식회사 Strip supply device

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