KR101311435B1 - 모듈 융합 단백질 발현 생성물의 제조 방법 - Google Patents

모듈 융합 단백질 발현 생성물의 제조 방법 Download PDF

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KR101311435B1
KR101311435B1 KR1020087011967A KR20087011967A KR101311435B1 KR 101311435 B1 KR101311435 B1 KR 101311435B1 KR 1020087011967 A KR1020087011967 A KR 1020087011967A KR 20087011967 A KR20087011967 A KR 20087011967A KR 101311435 B1 KR101311435 B1 KR 101311435B1
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reading frame
open reading
restriction enzyme
polynucleotide
overhang
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KR20080080096A (ko
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토마스 리드
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인트렉손 코포레이션
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1031—Mutagenizing nucleic acids mutagenesis by gene assembly, e.g. assembly by oligonucleotide extension PCR
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

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  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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  • Enzymes And Modification Thereof (AREA)
KR1020087011967A 2005-10-19 2006-10-19 모듈 융합 단백질 발현 생성물의 제조 방법 Expired - Fee Related KR101311435B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72825905P 2005-10-19 2005-10-19
US60/728,259 2005-10-19
PCT/US2006/060065 WO2007076166A2 (en) 2005-10-19 2006-10-19 Methods of making modular fusion protein expression products

Publications (2)

Publication Number Publication Date
KR20080080096A KR20080080096A (ko) 2008-09-02
KR101311435B1 true KR101311435B1 (ko) 2013-09-25

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US (3) US8153598B2 (https=)
EP (2) EP2426196B1 (https=)
JP (1) JP5492415B2 (https=)
KR (1) KR101311435B1 (https=)
CN (2) CN103215294B (https=)
AU (1) AU2006330773B2 (https=)
CA (1) CA2626666C (https=)
DK (2) DK1948804T3 (https=)
ES (2) ES2477285T3 (https=)
IL (1) IL190884A (https=)
IN (1) IN266806B (https=)
NZ (1) NZ568106A (https=)
WO (1) WO2007076166A2 (https=)

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US7785871B2 (en) * 2002-10-09 2010-08-31 Intrexon Corporation DNA cloning vector plasmids and methods for their use
JP2007537755A (ja) * 2004-05-18 2007-12-27 イントレクソン コーポレイション Ｄｎａクローニングベクタープラスミドのダイナミックなベクター構築のための方法
US8153598B2 (en) 2005-10-19 2012-04-10 Intrexon Corporation PKD ligands and polynucleotides encoding PKD ligands
US7943732B2 (en) 2006-06-05 2011-05-17 Intrexon Corporation AKT ligands and polynucleotides encoding AKT ligands
US8993263B2 (en) * 2006-08-07 2015-03-31 Intrexon Corporation PKA ligands and polynucleotides encoding PKA ligands
US8999666B2 (en) * 2006-08-09 2015-04-07 Intrexon Corporation PKC ligands and polynucleotides encoding PKC ligands
US8283445B2 (en) 2006-11-13 2012-10-09 Intrexon Corporation Extracellular-signal-regulated-kinase (ERK) heteropolyligand polypeptide
US8729225B2 (en) 2006-11-13 2014-05-20 Intrexon Corporation Glycogen synthase kinase heteropolyligand polypeptide
US7705122B2 (en) * 2006-12-04 2010-04-27 Intrexon Corporation mTOR ligands and polynucleotides encoding mTOR ligands
EP2537924B1 (en) 2007-03-27 2015-03-18 Intrexon Corporation MEK ligands and polynucleotides encoding mek ligands
WO2008137681A2 (en) * 2007-05-02 2008-11-13 Intrexon Corporation Pp1 ligands
BRPI0906867A2 (pt) * 2008-01-09 2019-09-24 Intrexon Corp inibidores terapêuticos da função pai-1 e métodos de uso dos mesmo
US9487808B2 (en) 2010-09-24 2016-11-08 Massachusetts Institute Of Technology Rapid assembly of multiple arbitrary length DNA fragments
WO2015070210A1 (en) 2013-11-11 2015-05-14 Wake Forest University Health Sciences Epha3 and multi-valent targeting of tumors
EP4282979A3 (en) * 2015-09-01 2024-02-28 The Regents of the University of California Modular polypeptide libraries and methods of making and using same
WO2018017144A1 (en) 2016-07-19 2018-01-25 Brandeis University Compositions and methods for identifying rna binding polypeptide targets
US20240409975A1 (en) * 2021-09-27 2024-12-12 Intergalactic Therapeutics, Inc. Synthetic production of circular dna vectors

Citations (2)

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US20050040336A1 (en) * 2001-11-16 2005-02-24 Akkerman Peter Jensen Method and apparatus for performing measurements on packaging for a fluid product
US20050176099A1 (en) * 2003-11-12 2005-08-11 Schering Corporation Plasmid system for multigene expression

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US7943732B2 (en) * 2006-06-05 2011-05-17 Intrexon Corporation AKT ligands and polynucleotides encoding AKT ligands
US8993263B2 (en) * 2006-08-07 2015-03-31 Intrexon Corporation PKA ligands and polynucleotides encoding PKA ligands
US8999666B2 (en) * 2006-08-09 2015-04-07 Intrexon Corporation PKC ligands and polynucleotides encoding PKC ligands
US8729225B2 (en) * 2006-11-13 2014-05-20 Intrexon Corporation Glycogen synthase kinase heteropolyligand polypeptide
US8283445B2 (en) * 2006-11-13 2012-10-09 Intrexon Corporation Extracellular-signal-regulated-kinase (ERK) heteropolyligand polypeptide
US7705122B2 (en) * 2006-12-04 2010-04-27 Intrexon Corporation mTOR ligands and polynucleotides encoding mTOR ligands
EP2537924B1 (en) 2007-03-27 2015-03-18 Intrexon Corporation MEK ligands and polynucleotides encoding mek ligands

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US20050040336A1 (en) * 2001-11-16 2005-02-24 Akkerman Peter Jensen Method and apparatus for performing measurements on packaging for a fluid product
US20050176099A1 (en) * 2003-11-12 2005-08-11 Schering Corporation Plasmid system for multigene expression

Also Published As

Publication number Publication date
CA2626666A1 (en) 2007-07-05
DK2426196T3 (da) 2014-07-07
EP2426196B1 (en) 2014-04-02
US8603807B2 (en) 2013-12-10
CN103215294B (zh) 2015-09-09
US8153598B2 (en) 2012-04-10
ES2477285T3 (es) 2014-07-16
CA2626666C (en) 2015-12-08
ES2436277T3 (es) 2013-12-30
JP2009512441A (ja) 2009-03-26
JP5492415B2 (ja) 2014-05-14
KR20080080096A (ko) 2008-09-02
CN103215294A (zh) 2013-07-24
US20090123973A1 (en) 2009-05-14
IN266806B (https=) 2015-06-03
AU2006330773B2 (en) 2012-06-07
EP1948804B1 (en) 2013-08-21
IL190884A (en) 2012-12-31
NZ568106A (en) 2012-08-31
US8993531B2 (en) 2015-03-31
EP1948804A2 (en) 2008-07-30
CN101395263A (zh) 2009-03-25
WO2007076166A3 (en) 2008-11-20
WO2007076166A2 (en) 2007-07-05
AU2006330773A1 (en) 2007-07-05
IL190884A0 (en) 2008-11-03
US20120195866A1 (en) 2012-08-02
DK1948804T3 (da) 2013-11-25
US20090215173A1 (en) 2009-08-27
EP2426196A1 (en) 2012-03-07
EP1948804A4 (en) 2009-05-13

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