KR101250029B1 - Hbv 감염 또는 hbv-매개 질병의 예방/치료를 위한조성물 - Google Patents

Hbv 감염 또는 hbv-매개 질병의 예방/치료를 위한조성물 Download PDF

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KR101250029B1
KR101250029B1 KR1020067004038A KR20067004038A KR101250029B1 KR 101250029 B1 KR101250029 B1 KR 101250029B1 KR 1020067004038 A KR1020067004038 A KR 1020067004038A KR 20067004038 A KR20067004038 A KR 20067004038A KR 101250029 B1 KR101250029 B1 KR 101250029B1
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hbsag
hbv
pharmaceutical composition
ayw
mice
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KR20070019632A (ko
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칼 멜베르
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라인 비오테크 게셀새프트 퓌르 너이에 비오테크놀로지세 프로제세 운트 프로덕테 엠비에이치
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KR1020067004038A 2003-08-29 2004-08-27 Hbv 감염 또는 hbv-매개 질병의 예방/치료를 위한조성물 Expired - Fee Related KR101250029B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10339927A DE10339927A1 (de) 2003-08-29 2003-08-29 Zusammensetzung zur Prophylaxe/Therapie von HBV-Infektionen und HBV-vermittelten Erkrankungen
DE10339927.5 2003-08-29
PCT/EP2004/009590 WO2005023297A1 (de) 2003-08-29 2004-08-27 Zusammensetzung zur prophylaxe/therapie von hbv-infektionen und hbv-vermittelten erkrankungen

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020127003977A Division KR20120026138A (ko) 2003-08-29 2004-08-27 Hbv 감염 또는 hbv-매개 질병의 예방/치료를 위한 조성물

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Publication Number Publication Date
KR20070019632A KR20070019632A (ko) 2007-02-15
KR101250029B1 true KR101250029B1 (ko) 2013-04-09

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Application Number Title Priority Date Filing Date
KR1020067004038A Expired - Fee Related KR101250029B1 (ko) 2003-08-29 2004-08-27 Hbv 감염 또는 hbv-매개 질병의 예방/치료를 위한조성물
KR1020127003977A Ceased KR20120026138A (ko) 2003-08-29 2004-08-27 Hbv 감염 또는 hbv-매개 질병의 예방/치료를 위한 조성물

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KR1020127003977A Ceased KR20120026138A (ko) 2003-08-29 2004-08-27 Hbv 감염 또는 hbv-매개 질병의 예방/치료를 위한 조성물

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US (2) US20060233832A1 (https=)
EP (1) EP1660125B1 (https=)
JP (1) JP4740133B2 (https=)
KR (2) KR101250029B1 (https=)
CN (1) CN1874787B (https=)
AU (1) AU2004269882B2 (https=)
BR (1) BRPI0414026A (https=)
CA (1) CA2535734A1 (https=)
DE (1) DE10339927A1 (https=)
ES (1) ES2541123T3 (https=)
WO (1) WO2005023297A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1764369A1 (de) 2005-09-16 2007-03-21 Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH Vakzine enthaltend trunkiertes HBV core protein plus Saponin-basierendes Adjuvants
KR100836745B1 (ko) * 2007-01-31 2008-06-10 (주)두비엘 Hbv 백신 및 그의 제조 방법
US8293101B2 (en) 2009-03-13 2012-10-23 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
TWI555531B (zh) * 2009-08-07 2016-11-01 傳斯堅公司 用以治療b型肝炎病毒(hbv)感染之組成物
US10076570B2 (en) 2009-08-07 2018-09-18 Transgene S.A. Composition for treating HBV infection
US9238679B2 (en) * 2011-02-11 2016-01-19 The Trustees Of The University Of Pennslyvania Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same
EA028659B1 (ru) * 2011-02-12 2017-12-29 Глоубиммьюн, Инк. Терапевтическое средство на основе дрожжей для лечения хронического гепатита b
PH12019502377A1 (en) 2011-04-21 2022-11-14 Isis Pharmaceuticals Inc Modulation of hepatitis b virus (hbv) expression
EP2629096A1 (en) * 2012-02-20 2013-08-21 Roche Diagniostics GmbH HBV immunocomplexes for response prediction and therapy monitoring of chronic HBV patients
CN105263522B (zh) * 2013-05-31 2019-03-22 赛特瑞恩股份有限公司 可中和乙肝病毒的结合分子
JP6726676B2 (ja) * 2015-03-16 2020-07-22 ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト(ゲーエムベーハー)Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH) Hbv感染および関連症状を治療するための三重特異的結合分子
CN113058033B (zh) * 2019-12-16 2024-07-09 远大赛威信生命科学(南京)有限公司 一种用于预防和治疗乙型肝炎的药物组合物及其用途
US20250101083A1 (en) * 2022-01-25 2025-03-27 Xiamen University Epitope peptide and antibody for treating hbv infection and related diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0511854A1 (en) * 1991-04-29 1992-11-04 Merck & Co. Inc. Multiple hepatitis B virus surface proteins which form particles
EP0533263A2 (en) * 1991-09-20 1993-03-24 Merck & Co. Inc. A multivalent hepatitis B virus vaccine

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196194A (en) * 1979-05-24 1993-03-23 The Regents Of The University Of California Vaccines containing Hepatitis B S-protein
EP0389983A3 (en) * 1989-03-31 1991-01-16 Abbott Laboratories Monoclonal antibodies to pres2 and pres1 polypeptides of the hepatitis b viral envelope
PT97632A (pt) * 1990-05-11 1992-03-31 Scripps Clinic Res Processo de obtencao de polipeptidos relacionados com a proteina do antigenio de superficie do virus da hepatite b e de vacinas que os contem
CA2041772A1 (en) * 1990-05-11 1991-11-12 Larry T. Mimms Monoclonal antibodies to pres2 and pres1 polypeptide of the hepatitis b viral envelope
EP0491077A1 (en) * 1990-12-19 1992-06-24 Medeva Holdings B.V. A composition used as a therapeutic agent against chronic viral hepatic diseases
US6133244A (en) * 1993-10-22 2000-10-17 Institut Pasteur Method for immunization against hepatitis B
ZA973367B (en) * 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
GB9608626D0 (en) * 1996-04-25 1996-07-03 Univ College Of London Hepatitis b monoclonal antibodies
CA2392853A1 (en) * 1999-12-03 2001-06-07 Innogenetics N.V. Hbv sequences
JP2001294599A (ja) * 2000-04-12 2001-10-23 Sekisui Chem Co Ltd 組み換えb型肝炎ウィルス表面抗原
RU2286172C2 (ru) * 2000-08-17 2006-10-27 Трипеп Аб Вакцины, содержащие рибавирин, и способы их использования
RU2233673C1 (ru) * 2003-03-31 2004-08-10 Закрытое акционерное общество научно-производственная компания "Комбиотех" Комбинированная вакцина для иммунопрофилактики коклюша, дифтерии, столбняка и вирусного гепатита в и д
RU2233672C1 (ru) * 2003-03-31 2004-08-10 Закрытое акционерное общество научно-производственная компания "Комбиотех" Комбинированная вакцина для иммунопрофилактики вирусного гепатита в и д, столбняка и дифтерии

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0511854A1 (en) * 1991-04-29 1992-11-04 Merck & Co. Inc. Multiple hepatitis B virus surface proteins which form particles
EP0533263A2 (en) * 1991-09-20 1993-03-24 Merck & Co. Inc. A multivalent hepatitis B virus vaccine

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CA2535734A1 (en) 2005-03-17
KR20070019632A (ko) 2007-02-15
AU2004269882A1 (en) 2005-03-17
US20110263822A1 (en) 2011-10-27
JP4740133B2 (ja) 2011-08-03
US20060233832A1 (en) 2006-10-19
CN1874787B (zh) 2012-09-19
CN1874787A (zh) 2006-12-06
WO2005023297A1 (de) 2005-03-17
EP1660125A1 (de) 2006-05-31
AU2004269882B2 (en) 2010-02-18
KR20120026138A (ko) 2012-03-16
EP1660125B1 (de) 2015-05-06
HK1100812A1 (en) 2007-09-28
JP2007504112A (ja) 2007-03-01
DE10339927A1 (de) 2005-03-24
ES2541123T3 (es) 2015-07-16
BRPI0414026A (pt) 2006-10-24

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