KR101243013B1 - 펩타이드 중간체 단편을 사용하여 펩타이드 ｔ-20을합성하는 방법 - Google Patents

펩타이드 중간체 단편을 사용하여 펩타이드 ｔ-20을합성하는 방법 Download PDF

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Publication number
KR101243013B1
KR101243013B1 KR1020077017404A KR20077017404A KR101243013B1 KR 101243013 B1 KR101243013 B1 KR 101243013B1 KR 1020077017404 A KR1020077017404 A KR 1020077017404A KR 20077017404 A KR20077017404 A KR 20077017404A KR 101243013 B1 KR101243013 B1 KR 101243013B1
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KR
South Korea
Prior art keywords
peptide
seq
resin
solution
sup
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020077017404A
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English (en)
Korean (ko)
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KR20070103400A (ko
Inventor
연-퀘이 한
데이비드 에이 존스톤
히랄랄 엔 카트리
Original Assignee
에프. 호프만-라 로슈 아게
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Publication of KR20070103400A publication Critical patent/KR20070103400A/ko
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Publication of KR101243013B1 publication Critical patent/KR101243013B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16—HIV-1 ; HIV-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020077017404A 2004-12-30 2005-12-22 펩타이드 중간체 단편을 사용하여 펩타이드 ｔ-20을합성하는 방법 Expired - Fee Related KR101243013B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64091104P 2004-12-30 2004-12-30
US60/640,911 2004-12-30
PCT/EP2005/013853 WO2006069728A1 (en) 2004-12-30 2005-12-22 Synthesis of peptide t-20 using peptide intermediate fragments

Publications (2)

Publication Number Publication Date
KR20070103400A KR20070103400A (ko) 2007-10-23
KR101243013B1 true KR101243013B1 (ko) 2013-03-14

Family

ID=36025222

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077017404A Expired - Fee Related KR101243013B1 (ko) 2004-12-30 2005-12-22 펩타이드 중간체 단편을 사용하여 펩타이드 ｔ-20을합성하는 방법

Country Status (12)

Country Link
US (1) US20060276624A1 (https=)
EP (1) EP1833843B1 (https=)
JP (1) JP4886702B2 (https=)
KR (1) KR101243013B1 (https=)
CN (1) CN101133077B (https=)
AT (1) ATE445636T1 (https=)
CA (1) CA2592438C (https=)
DE (1) DE602005017188D1 (https=)
ES (1) ES2332418T3 (https=)
IL (1) IL184080A (https=)
MX (1) MX2007007917A (https=)
WO (1) WO2006069728A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050261475A1 (en) * 2004-02-13 2005-11-24 Harvard Medical School Solid-phase capture-release-tag methods for phosphoproteomic analyses
ES2329270T3 (es) * 2004-12-30 2009-11-24 F. Hoffmann-La Roche Ag Sintesis del peptido t-1249 utilizando fragmentos intermediarios del ipeptido.
JP5473925B2 (ja) * 2007-10-27 2014-04-16 コーデン ファーマ コロラド インコーポレイテッド 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成
BRPI0820765A2 (pt) * 2007-12-11 2015-06-16 Hoffmann La Roche Métodos para a produção de um peptídeo insulinotrópico e peptídeos
CN110372781B (zh) * 2019-07-29 2021-11-16 深圳佳肽生物科技有限公司 恩夫韦肽的制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015881A (en) * 1998-03-23 2000-01-18 Trimeris, Inc. Methods and compositions for peptide synthesis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4010560B2 (ja) * 1992-07-20 2007-11-21 ドューク ユニバーシティー Ｈｉｖ複製を阻害する化合物
US6281335B1 (en) * 1993-10-08 2001-08-28 Coulter Corporation Hybridoma and anti-KC-4 humanized monoclonal antibody
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US6479055B1 (en) * 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US5817758A (en) * 1995-06-07 1998-10-06 Terrapin Technologies, Inc. P-nitrobenzyl side-chain protection for solid-phase synthesis
CA2324348C (en) * 1998-03-23 2006-03-14 Trimeris, Inc. Methods and compositions for peptide synthesis
US6469136B1 (en) * 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis
US20040209999A1 (en) * 2002-08-16 2004-10-21 Bohling James Charles Method of manufacturing polypeptides, including T-20 and T-1249, at commercial scale, and polypeptide compositions related thereto
AU2004200485A1 (en) * 2003-02-25 2004-09-09 Rohm And Haas Company Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto
ES2329270T3 (es) * 2004-12-30 2009-11-24 F. Hoffmann-La Roche Ag Sintesis del peptido t-1249 utilizando fragmentos intermediarios del ipeptido.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015881A (en) * 1998-03-23 2000-01-18 Trimeris, Inc. Methods and compositions for peptide synthesis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Current Opinion in Chemical Biology, Vol. 8, pp. 211-221 (2004.04.12.) *

Also Published As

Publication number Publication date
MX2007007917A (es) 2007-08-14
WO2006069728A1 (en) 2006-07-06
IL184080A (en) 2010-12-30
US20060276624A1 (en) 2006-12-07
KR20070103400A (ko) 2007-10-23
EP1833843B1 (en) 2009-10-14
CA2592438A1 (en) 2006-07-06
DE602005017188D1 (de) 2009-11-26
EP1833843A1 (en) 2007-09-19
ATE445636T1 (de) 2009-10-15
JP4886702B2 (ja) 2012-02-29
IL184080A0 (en) 2007-10-31
CN101133077A (zh) 2008-02-27
CA2592438C (en) 2013-09-03
ES2332418T3 (es) 2010-02-04
CN101133077B (zh) 2012-09-05
JP2008526698A (ja) 2008-07-24

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MXPA02000021A (es) Metodos y composiciones para la sintesis de peptidos.
WO2005063799A2 (en) Peptide synthesis and deprotection with co-solvent
KR101243013B1 (ko) 펩타이드 중간체 단편을 사용하여 펩타이드 ｔ-20을합성하는 방법
EP1701972B1 (en) Process and systems for recovery of peptides
CA2593864C (en) Synthesis using peptide intermediate fragments iii
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