KR101203768B1 - Low-frequency stimulation electrode conductive hydrogel patch containing ingredients for alleviating pain and inflammation - Google Patents

Abstract

The present invention generates a low frequency from the low frequency oscillator to provide a low frequency treatment to the contact surface of the human body, as well as low frequency for drug delivery designed to deliver drugs of pain relief agents and anti-inflammatory agents such as neuralgia, myalgia, menstrual pain, bruises to the skin. The present invention relates to a stimulator conductive hydrogel electrode patch (FIGS. 1 and 3), wherein a snap terminal (70a, 70b) capable of connecting to a low frequency oscillator and a wire (20, 21) and a terminal (22) of a connector type (22) and an electrode protection fabric ( 10, 60), conductive electrodes 30, 80a, 80b; conductive film coating on conductive films or films), conductive hydrogels for low frequency stimulators that can be connected by attachment between conductive electrodes 30, 80a, 80b and the treatment site ( 40, 90a, 90b), consisting of release paper (50, 100) to protect the conductive hydrogel, the low-frequency stimulator conductive hydrogel (40, 90a, 90b) is characterized in that it contains pain and inflammation relief components It is gong.
The low frequency stimulator conductive hydrogel electrode patch containing the pain and inflammation-relieving component according to the present invention can be used as a pain relieving part when used without being connected to the low frequency oscillator, and when used in connection with the low frequency oscillator Simultaneously with the treatment, there is an advantage that can further include the drug that is not included in the existing low frequency stimulator and the effect of the drug and the skin penetration effect of the drug by the low frequency.

Description

      Low-frequency stimulation electrode conductive hydrogel patch containing ingredients for alleviating pain and inflammation}

  The present invention can be implemented not only to exhibit the physical effect of the low-frequency stimulation of the conductive hydrogel that can be used for the existing low-frequency stimulator, but also contains a pain and inflammation relieving component in the low-frequency conductive hydrogel, thereby providing a phonophoresis system. The drug delivery technology can be applied, and thus, the low frequency stimulator and the active ingredient of the drug can all exhibit complementary effects that can be applied to patients suffering from bruises, muscle pain, neuralgia, and arthritis related to pain and inflammation. Will be.

On the other hand, in order to realize such product performance, unlike the conventional cataplasma or poultice agent manufactured for anti-inflammatory analgesic, by implementing the electrode properties to have the same performance as the conductive hydrogel manufacturing method for low-frequency stimulator, it is possible to implement the conventional wave formulation or low frequency Differentiation with the stimulator will be implemented in parallel hybrid technology, and can help the effective transdermal penetration of the drug.

      The present invention relates to a conductive hydrogel composition for a low frequency stimulator and an electrode patch composition for a low frequency stimulator containing a pain relief and inflammation relief component, and more particularly, to include a pain relief and inflammation relief component in an existing conductive hydrogel. When used in conjunction with a stimulator, it not only has a physical pain relief effect, but also expresses a therapeutic effect by a drug at the same time, and can be used as a normal parcel in normal use, and when a quick skin penetration of the drug is required or a conductive hydro Low-frequency oscillators in conjunction with low-frequency oscillators, when the drug concentration in the gel and the affected surfaces reach equilibrium and no further drug penetration occurs, or when the drug is no longer delivered to the skin in the conducting hydrogel. Through the physical frequency occurring in It is possible to increase the penetration effect.

      Conductive hydrogels are for electrocardiograms (ECG), low frequency stimulators (TENS), dispersive electrodes, and DEFI PADs (defibration electrodes). It is a material contained within and configured to serve as an interface between the electrode and the skin interface. Among them, the conductive hydrogel to be applied in the present invention is a conductive hydrogel contained in a low frequency stimulator. The low frequency stimulator is a method of treating the pain caused by various causes by stimulating the peripheral sensory nerve of the skin by using electric current.The conductive hydrogel used for the low frequency stimulator must contain an appropriate electrolyte and satisfy the electrical characteristics such as impedance. In order to control the various vibration waveforms and the intensity of the vibration to the treatment site can be delivered accurate signal. Vibration and generated signal from the low frequency generator must be accurately transmitted to the treatment site to increase its treatment efficiency. In addition, the use of a conductive hydrogel that does not satisfy the electrical properties due to the lack of an appropriate electrolyte, etc., the output of low-frequency stimulus signal is weak, or the electrical stimulation is felt strongly to the patient, the user will suffer pain, more seriously The problem is that the skin is burned. Therefore, if the resistance value of the low frequency stimulator does not satisfy a certain level of resistance value in the frequency domain used as the low frequency stimulator, the above serious problems may be reached.

       The low frequency stimulator currently on the market releases muscles or body tissues that are stuck only by physical vibration or electric stimulation without drugs and transmits low frequency stimulus signals instead of pain nerve pathways felt from pain points distributed on the skin to relieve pain. Is given. However, most painful areas are accompanied by inflammatory reactions. If the pain is only temporarily relieved, the inflammation does not go away, and if left untreated, the area of inflammation that extends from the initial pain point is exacerbated. Will result. Therefore, in the physical therapy room of the hospital, such as low-frequency stimulation in parallel with the anti-inflammatory pain lotion or gel or use a therapy to paste. In case of severe inflammation, oral medications may be prescribed.

     Receiving medications such as low-frequency stimulation and chemical anti-inflammatory drugs, which are performed in physiotherapy rooms in hospitals, is accompanied by the inconvenience of being bound by time and place for busy modern people. On the other hand, even when used at home with an anti-inflammatory analgesic cream or gel, there is a problem that the drug may be buried in areas other than clothes or affected areas, the drug is lost. In addition, anti-inflammatory analgesic gels or creams do not last as long as a patch, so the duration of pain and anti-inflammatory drugs are significantly reduced. Therefore, in order to increase the drug persistence and drug persistence, a patch-type paste is commercially available, but in the case of trauma pain and muscle spasms, neuralgia caused by muscle or tissue agglomeration, and other tired and clumped muscles In order to loosen the tissues, it is impossible to treat them simply by pharmacotherapy, and there is a clear need for continuous physical therapy through low frequency stimulation, vibration or massage therapy. In addition, in this case, the principle of permeation of the drug is indicated by diffusion due to the difference in concentration between the adhesive layer and the skin, including the drug. When the drug reaches the concentration equilibrium after the drug is penetrated into the skin, the drug is included. The drug is not delivered to the percutaneous layer in the adhesive layer and remains in the adhesive layer, resulting in a poor treatment effect.

       Therefore, in order to overcome these disadvantages, and to deliver drugs with the treatment of vibration or massage therapy, the anti-inflammatory analgesic components currently marketed in the registered patent 10-025835 10-0245836, Utility Model Registration 20-0375948, 20-0199097 It describes the use of two products interchangeably by replacing various types of pastes (cataplasm, poultice, patch, plaster) with conductive gel of low frequency stimulator.

      The pastes that can be used as the conductive gel for low frequency stimulator mentioned in the above patents and utility models include cataplasma and poultice among cataplasm, patch, plaster and poultice. However, since these cataplasmas and poultices are not formulated with the requirements of low frequency stimulator conductive hydrogels, they are not only designed for the low frequency stimulator, but also have low electricity consumption, low efficiency, and low conductivity and uniform conductivity distribution. Because it can not have the skin due to electrical resistance can be burned and the like.

       The difference between the cataplasmase and the poultice agent and the low-frequency conductive hydrogel may be understood from the reason that the method of manufacturing the composition of the low-frequency stimulator conductive gel and the paste (foaming agent, cataplasma agent) is different.

       Table 1 is a comparative example of the basic composition of pastes and conductive hydrogels such as cataplasm and poultice, and the composition of the paste (foaming agent, cataplasma) of Table 1 is shown as the main component of the adhesive. Sodium copolymer is used, and polyvinyl alcohol, gelatin, sodium carboxymethyl cellulose, polyvinylpyrrolidone, polyethylene oxide and the like are used as other auxiliary adhesives. As an excipient for controlling the curing reaction, a polycation (aluminum metal salt) compound, EDTA (ethylenediamine triacetic acid), and organic acids (tartaric acid, etc.) are added. On the other hand, menthol, menthyl lactate, other menthol derivatives, peppermint oil, capsaicin, etc., which are anti-irritants of cooling and warming, are added as main ingredients, and various drugs and extracts are added as ingredients for anti-inflammatory and skin soothing.

On the other hand, the conductive hydrogel is made of a high molecular material and compared to the high viscosity cataplasma paste, since it is used by polymerizing a low molecular weight material with a crosslinking agent, it is easy to control the viscosity and homogeneous electrolyte at low viscosity compared to the cataplasma paste formulation. It can mix | blend it easily, and it becomes possible to have uniform conductivity distribution. In addition to such a uniform conductivity distribution, even when the pain and inflammation-releasing component is contained, the uniformity of the drug is well maintained, and when applied to a low frequency stimulator, the therapeutic effect can be increased.

 Comparison of Cataplasmase and Conductive Hydrogel Excipient Compositions ingredient Purpose of Mixing Cataplasm (foaming agent)
(weight%) Conductive Hydrogel
(weight%) Polyacrylic acid and
Sodium copolymer
(Mw = 1.5 million to 2 million)
Adhesive 3 to 8 - Acrylic acid or
Vinyl monomers Adhesive - 10 to 30 Water Soluble Polymer
(Gelatin, CMC Na,
Polyvinyl alcohol, etc.) Adhesive
or
Incrementer 2 to 10  1 to 5 Polyhydric alcohol
(Glycerine, PG, etc.) Anti-wetting agent 30 to 60 20 to 60 Purified water solvent Remainder Remainder Ionic compounds Electrolyte 0.5 to 3.0
(Al chemicals / EDTA Na) 3 to 10
(Na, K, etc.) Other additives Bridge, preservation 0.2 to 4.0 0.2 to 4.0 Viscosity (cps) 20,000-30,000 200 ~ 5000 adjustable

       When using the conductive gel of the low frequency stimulator, it is important to satisfy the electrical characteristics as mentioned above.

       The electrical properties requirements of the conducting gel should have adequate resistance in the frequency range where low frequency stimulators can be used.

For example, a low-frequency stimulator that is safe for the patient if the resistance value according to frequency is measured at 10Hz 161Ω, 1KHz 27Ω, 10KHz 19Ω, and has a similar range of resistance values according to frequency within a reliable standard deviation range. Ensures the use of However, if the deviation range of these values is large or the resistance value is too high, the electrode surface temperature rises to about 52 ^o C due to the high resistance as shown in Fig. 1, and burns may occur.

[Figure 1] Schematic of thermal image when hydrogel with high resistance value and non-uniform conductivity is applied to low frequency stimulator

      The present invention is a variety of pars (cataplasm, poultice, patch, plaster) containing the currently marketed anti-inflammatory analgesic mentioned in the above-mentioned Patent Registration 10-025835 10-0245836, Utility Model Registration 20-0375948, 20-0199097 It is difficult to have a uniform conductivity when using a poultice agent as a conductive hydrogel for a low frequency stimulator by replacing with a conductive gel of a low frequency stimulator. Problems such as skin electrical imaging due to resistance to solve the problem by containing an anti-inflammatory analgesic component in the low-frequency conductive hydrogel of the present invention.

In addition, the conductive hydrogel electrode patch for the low frequency stimulator containing the pain and inflammation-releasing component according to the present invention can be used as a pain relief part when separated and used without being connected to the low frequency oscillator, and when used in connection with the low frequency oscillator In addition to the physical therapy, such as the existing low frequency stimulator further contains a drug that is designed to double the effect of the drug and the skin penetration effect of the drug by the low frequency.

In order to achieve the above object, a low-frequency stimulator conductive hydrogel electrode patch for drug delivery (FIG. 1, FIG. 3) designed to deliver the drug of the pain-relief and inflammation-releasing agent of the present invention to the skin will be described in detail.

      1 is a perspective view of a patch compatible with a wired home low frequency stimulator as a conductive hydrogel patch for a low frequency stimulator containing pain and inflammation relieving components, and FIG. 3 is a perspective view of a patch compatible with a portion of a home type low frequency stimulator of a wireless type. . The configuration of a patch compatible with the wired home low frequency stimulator of FIG. 1 is connected to the low frequency oscillator and connects a signal from the first low frequency stimulator to the low frequency electrode patch so that the wires 20 and 21 and the connector terminal 22 can be connected. ), An electrode protection fabric 10 configured to protect the conductive electrode 30 and to prevent the current generated from the low frequency stimulator from being directly applied to the human body, and to transmit the low frequency signal flowing from the terminal to the conductive hydrogel 30. Conductive electrode 30 (conductive film or a conductive ink coating on the film), the conductive electrode 30 and the treatment portion can be connected by the attachment method, a medium for delivering a low-frequency stimulation signal to reach the human body, the pain, And a conductive hydrogel 40 for low frequency stimulator containing an anti-inflammatory component, a low frequency stimulator containing the drug It characterized in that the configuration of conductive hydrogel 40 to the release paper 50 to protect.

      The configuration of the patch compatible with the wireless low frequency stimulator of the wireless type of Figure 3 is connected to the low frequency oscillator snap terminal (70a, 70b), a conductive electrode that can connect the signal from the low frequency stimulator to be delivered to the low frequency electrode patch for the first time An electrode protection fabric 60 configured to protect the current generated from the low frequency stimulator so as not to be directly applied to the human body, and a conductive electrode 80a configured to transmit the low frequency signal flowing from the snap terminals 70a and 70b to the conductive hydrogel. Conductive film or conductive ink coating on the film), the conductive electrodes (80a, 80b) and the treatment portion can be connected to the attachment method, and a medium for delivering a low-frequency stimulation signal to reach the human body, pain and Conductive hydrogels (90a, 90b) for low frequency stimulator containing an anti-inflammatory component, low containing the drug It characterized by comprising a wave stimulation appointed conductive hydrogel (90a, 90b) to the release paper 100, which may be protected.

The present invention is a physical and chemical treatment performed in the hospital at the same time accompanied by a low-frequency pharmacological action as well as a therapeutic effect by the pain and inflammation-releasing components as mentioned above in case of injury such as bruises, muscle pain, neuralgia, arthritis, etc. Therapies can be easily used at home, and the treatment effect can be greatly improved at low cost by eliminating the inconvenience of having to separately use a pars or a low frequency stimulator.

      In addition, when using existing pars, the drug balances the concentration between the parsing adhesive layer and the skin, so that skin penetration due to drug diffusion can no longer be achieved. There is an advantage that can minimize the remaining amount of the drug to be effective by minimizing the drug that can be contained in the low-frequency conductive hydrogel layer.

1 is a perspective view of a product compatible with a domestic priority type low frequency stimulator of a conductive hydrogel electrode patch for a low frequency stimulator containing the pain and inflammation relief component of the present invention;
2 is an exploded perspective view of FIG. 1;
3 is a perspective view of a product compatible with a domestic wireless type low frequency stimulator of a conductive hydrogel electrode patch for a low frequency stimulator containing the pain and inflammation relief component of the present invention;
4 is an exploded perspective view of FIG. 3;
5 is an exploded perspective view when the exploded perspective view of FIG. 4 is unfolded;

      An embodiment of the patch applied to the streamlined low frequency stimulator of the conductive hydrogel patch for the low frequency stimulator containing the pain inflammatory component of the present invention will be described in detail with reference to the accompanying drawings.

      The terminal that can be connected to the low frequency oscillator of FIG. 1 is configured to connect the positive and negative wires from the low frequency stimulator unit with the connector 22 on the patch, and the wire 20 on the opposite side of the connector is the conductive electrode 30. In contact with the peeled so as to apply the current is placed between the fabric 10 and the conductive electrode 30 as possible fan-shaped as possible.

      The electrode protection fabric 10 of FIG. 2 may be configured by mixing one or two or more of nonwoven fabric, polyurethane, nonwoven fabric and polyurethane blend, polyethylene film, OPP film or polymer fiber, and a low frequency oscillator connection method. The wires 20 and 21 are fixed and disposed on the conductive electrodes and the wires 20 and 21 so that current is not directly applied to the human body through the conductive electrode 30.

      The conductive electrode 30 for the low frequency stimulator of FIG. 2 is composed of anisotropic conductive films such as carbon, silver chloride, tin chloride, platinum, and other highly conductive metals, or conductive carbon, silver chloride, or the like on one side of the electrode protective fabric. It can be configured by coating the ink, and when the electric wires 20 and 21 of the connector method 22, which is the low frequency stimulator connection method, is connected to the conductive electrode 30, the pain and It is disposed between the conductive electrode 30 and the conductive hydrogel 40 so that a low frequency signal can be transmitted to the conductive hydrogel 40 containing the inflammation-releasing component.

      The low-frequency stimulator-conductive hydrogel 40 containing the pain and inflammation-relieving component of FIG. 2 is a sodium, potassium, calcium salt and N-vinyllactam or vinyl-based monomer, or such vinyl-based monomer as an adhesive. It is not limited to one of these monomers with sulfonic acid and amine groups, it is composed of 5.0 to 40.0% by weight of the total weight of the hydrogel, as a crosslinking agent having a vinyl group, acrylic group, methacrylate group or more than bi-functional group It is composed of 0.05 ~ 2.0% by weight of the total weight of the hydrogel, photo-initiator and thermal initiator is composed of 0.01 ~ 1.0% by weight of the total weight of the hydrogel as a polymerization initiator, and sodium cation, calcium cation, potassium cation as an electrolyte The ionic compound is comprised in the range of 0.1 to 10.0% by weight of the total weight of the hydrogel, and is used as a polyacrylic acid polymer, polyacrylic acid and salt as a thickener. Coated copolymers, polyethylene oxide, polyvinylpyrrolidone, polyvinyl alcohol, polyvinylpyrrolidone and polyvinyl alcohol copolymers, carboxymethyl cellulose and its salts, carbomers, gantrez, hydroxymethyl cellulose, hydroxy Hydroxyethylcellulose, poloxamer, methylcellulose, ethylcellulose, hydroxypropylmethylcellulose, corn protein extract, hydroxypropylmethylcellulose phthalate, pullulan, gelatin, eudragit, agar, carrageenan, pectic, gum (xanthan, guar) , Locust bean, Arabia, cassia, tara, tragacanth, etc.), starch, and at least one selected from the group consisting of glycerin, propylene glycol, butylene glycol, sorbitol, polyethylene glycol, polyglycol Polyhydric alcohols, such as propylene glycol, pentadiol, pentaerythritol, triglycerol, and trimethol propane It contains 0.5 to 40% by weight of the total weight of the hydrogel, and purified water contains 10.0 to 60.0% by weight of the total weight of the hydrogel, and as a pain-relieving ingredient, menthol, menthyllactate, and other menthol, which are anti-irritants for cooling and warming It is not limited to derivatives, peppermint oil, red pepper extract, capsaicin, gardenia extract, vigor, etc., and contains at least one of them and 0.1 to 5.0% by weight of the total weight of the hydrogel. Latex, indomethacin, ibuprofen, ketoprofen, flurbiprofen, felbinac, pyroxicam, camphor, diphenhydramine, glycyrrhizinic acid, licorice extract, achinacea extract, portulaca extract, sulfur extract, sulfur, It consists of one or two or more of these in gold and silver extracts, cedar extracts, donkey extracts, turmeric extracts, safflower extracts, calendula extracts and changja extracts. Binary is not limited in the group, and contains 0.1 to 5.0% by weight of the total weight of the hydrogel.

      The conductive hydrogel 40 for the low frequency stimulator containing the pain and inflammation-releasing component is disposed on the conductive electrode layer 30 so that the electric current generated from the low frequency stimulator when connected to the human body is connected to the low frequency stimulator and the connectors 20 and 21. (22), the pharmacological component and the low frequency signal effective for pain and inflammation through the conductive hydrogel 40 via the conductive electrode 30 is delivered together to exhibit a therapeutic effect.

      The release paper 50 of FIG. 2 protects the conductive hydrogel 40 before use, and may use a polyester film or paper coated with silicon to facilitate peeling during use. Can be used. The release paper 50 is disposed on the low-frequency stimulator conductive hydrogel 40 containing the pain and inflammation-releasing component so as to protect the conductive hydrogel layer for the low-frequency stimulator containing the pain and inflammation-releasing component until the product is used. do.

       Hereinafter, an embodiment of a patch applied to a wireless low frequency stimulator of a conductive hydrogel patch for a low frequency stimulator containing a pain inflammation-relaxing component of the present invention will be described in detail as follows.

      The terminal that can be connected to the low frequency oscillator of FIG. 5 is configured to connect the female snap terminals of the positive and negative poles coming out of the low frequency stimulator unit with the male snaps 70a and 70b of the positive and negative poles depending on the patch. The snap-head portion penetrates the conductive electrodes 80a and 80b and the fabric 60, and is positioned on the conductive hydrogel. When the snap is connected to the low-frequency stimulator unit, the positions of the positive and negative electrodes can be used without being determined.

      The electrode protective fabric 60 of FIG. 5 may be composed of one or two or more of a nonwoven fabric, polyurethane, nonwoven fabric and polyurethane blend, polyethylene film, OPP film or polymer fiber, and a male-shaped snap. The hole is penetrated enough to penetrate the head, and is disposed on the conductive electrode so that a current is not directly applied to the human body through the conductive electrode 30.

      The conductive electrodes 80a and 80b for the low frequency stimulator of FIG. 5 are made of anisotropic conductive films such as carbon, silver chloride, tin chloride, platinum, and other highly conductive metals, or carbon, silver chloride, or the like on one side of the electrode protective fabric. It can be configured by coating a conductive ink of, the hole is penetrated enough to penetrate the head of the male-shaped snap, and is located between the conductive hydrogel (90a, 90b) and the fabric 60 from the low frequency stimulator The current flowing out is disposed to be applied to the conductive hydrogels 90a and 90b via the snaps 70a and 70b.

      Conductive hydrogels 90a and 90b for the low frequency stimulator containing the pain and inflammation-relieving component of FIG. 5 are sodium, potassium, calcium, and N-vinyllactam or vinyl-based monomers or vinyl-based monomers. Salts and monomers with sulfonic acid and amine groups are not limited to any one of them, and are composed of 5.0 to 40.0% by weight of the total weight of the hydrogel, and as a crosslinking agent, a vinyl group, an acryl group and a methacrylate group having a bifunctional group or more. It is composed of 0.05 ~ 2.0% by weight of the total weight of the hydrogel, photoinitiator and thermal initiator is composed of 0.01 ~ 1.0% by weight of the total weight of the hydrogel as a polymerization initiator, sodium cation, calcium cation, potassium cation as an electrolyte Ionic compounds such as the hydrogel is composed of 0.1 to 10.0% by weight of the total weight of the hydrogel, and as a thickener polyacrylic acid polymer, polyacrylic acid and salt Copolymer consisting of, polyethylene oxide, polyvinylpyrrolidone, polyvinyl alcohol, polyvinylpyrrolidone and polyvinyl alcohol copolymer, carboxymethyl cellulose and its salts, carbomer, gantrez, hydroxymethyl cellulose, hydroxy Oxyethylcellulose, poloxamer, methylcellulose, ethylcellulose, hydroxypropylmethylcellulose, corn protein extract, pullulan, gelatin, hydroxypropylmethylcellulose phthalate, eudragit, agar, carrageenan, pectic, gum (xanthan, guar) , Locust bean, Arabia, cassia, tara, tragacanth, etc.), starch, and at least one selected from the group consisting of glycerin, propylene glycol, butylene glycol, sorbitol, polyethylene glycol, polyglycol Polyhydric compounds such as propylene glycol, pentadiol, pentaerythritol, triglycerol, and trimetholpropane Cole contains 0.5 to 40% by weight of the total weight of the hydrogel, purified water contains 10.0 to 60.0% by weight of the total weight of the hydrogel, and as a pain relief component, menthol, menthyl lactate, It is not limited to other menthol derivatives, peppermint oil, red pepper extract, capsaicin, gardenia extract, vigor, etc., and contains at least one of these, 0.1 to 5.0% by weight of the total weight of the hydrogel, and salicylic acid glycol, methyl Salicylate, indomethacin, ibuprofen, ketoprofen, flurbiprofen, felbinac, pyroxicam, camphor, diphenhydramine, glycyrrhizinic acid, licorice extract, achinacea extract, march extract, munjuran extract, From sulfur, gold and silver extract, cephalophyllus, Angelica extract, turmeric extract, safflower extract, calendula extract, changja extract, etc. It is not limited to the group consisting of, and contains 0.1 to 5.0% by weight of the total weight of the conductive hydrogel. The thickness of the conductive hydrogel is applied to a thickness of 200 ~ 700 micro.

      The conductive hydrogels 90a and 90b for the low frequency stimulator containing the pain and inflammation-relieving components are disposed on the conductive electrode layers 80a and 80b, so that the current generated from the low frequency stimulator when connected to the human body is connected to the low frequency stimulator 70a, 70b), pharmacological components and low frequency signals effective for pain and inflammation are transmitted through conductive hydrogels 90a and 90b via conductive electrodes 80a and 80b to exhibit a therapeutic effect.

      The release paper 100 of FIG. 5 protects the conductive hydrogels 90a and 90b before use, and may use a polyester film or paper coated with silicon to facilitate peeling during use. A film etc. can be used. The release paper 100 is a low-frequency stimulator conductive hydrogel (90a, 90b) containing a pain and inflammation-releasing component so as to protect the conductive hydrogel layer for a low-frequency stimulator containing the pain and inflammation relief component until the use of the product Is placed on top.

      The manufacturing method of the conductive hydrogel 40, 90a, 90 for the low frequency stimulator containing the pain and inflammation-releasing component will be described in more detail based on the following examples, but the scope of the present invention is not limited thereto.

Example 1 Manufacturing Method Using Thermal Initiation Reaction of Conductive Hydrogel for Low Frequency Stimulator Containing Pain and Inflammatory Relief

Sodium polyacrylate and sodium hydroxide were dissolved in purified water and glycerin, and then added with a vinyl monomer, menthol, salicylic acid glycol, a crosslinking agent, and an initiator sequentially, followed by stirring, and then coated with about 400 micrometers on a siliconized polyethylene film. ^{o A} cross-linking reaction was carried out at C temperature to prepare a conductive hydrogel for pain and inflammation low frequency stimulator.

Example 2 Manufacturing Method Using UV Initiation Reaction of Conductive Hydrogel for Low Frequency Stimulator Containing Pain and Inflammation Relief

      Sodium polyacrylate and sodium hydroxide were dissolved in purified water and glycerin, and then added with a vinyl monomer, menthol, glycol salicylate, a crosslinking agent, and an initiator sequentially, followed by application of about 400 micrometers on a siliconized polyethylene film. A cross-linking reaction was conducted using a UV xenon lamp to prepare a conductive hydrogel for pain and inflammation relief low frequency stimulator.

Composition table of conductive hydrogel for low frequency stimulator containing pain and inflammation relief component ingredient Formulation purpose Example 1
(weight%) Example 2
(weight%) Acrylic Acid Beyond Adhesive 10.0 10.0 With sulfonic acid groups
Vinyl monomer Adhesive 10.0 5.0 With sodium base
Vinyl monomer Adhesive - 5.0 Sodium polyacrylate Adhesive 1.0 1.0 glycerin Anti-wetting agent 30.0 30.0 Purified water solvent Remainder Remainder Sodium hydroxide Electrolyte 5.0 5.0 Ammonium Persulfate Initiator 0.1 Benzyldimethyl ketal Initiator 0.1 Ethylene glycol
Dimethacrylate Cross-linking agent 0.1 0.1 menthol Pain relief ingredients 3.0 3.0 Salicylic acid glycol Anti-inflammatory ingredients 1.0 1.0 Sum 100.0 100.0

      Conductive hydrogel patch for pain and inflammation-relieving low frequency stimulator (Fig. 1, 3) configured as described above is accompanied by a drug effect by doubling the physical treatment effect and drug penetration effect by low frequency when used in connection with the low frequency stimulator In addition, when using the conventional pars, the drug has a concentration balance between the parsing layer and the skin, so that the drug is no longer penetrated and remains in the parsing layer. The amount of drug applied in the gel to remain in the patch can be minimized.

       The following briefly describes how to use the conductive hydrogel patch for low frequency stimulator containing the pain and inflammation-releasing component configured as described above.

       If a patient suffering from bruises, muscle pain, neuralgia, arthritis, etc. wants to use the product shown in Fig. 1, first check whether the household low-frequency stimulator that matches the connector size connected to the electrode is equipped (usually the internal diameter of the connector:: 1.95 ~ 커넥터 2.05mm) After connecting the connector to the low frequency stimulator, remove the release paper attached on the bottom of the electrode patch from the hydrogel, and apply it to the injury area, but separate the gap between the anode patch and the cathode patch by more than 3cm. After attaching, it is possible to use the same method of use as the conventional low frequency stimulator electrode by adjusting the low frequency stimulator and the low frequency stimulus intensity switch.

       On the other hand, if a patient suffering from bruises, muscle pain, neuralgia, arthritis, etc. wants to use the wireless type product (snap connection method) as shown in Fig. 3, the prepared low frequency stimulator checks whether the snap size of the present invention is correct, and then electrode patch After removing the release paper attached on the bottom surface from the hydrogel, apply it to the injured area, but because the gap between anode patch and cathode patch is fixed in advance, attach two patches at once and then switch the low frequency stimulator stimulation mode and the low frequency stimulus intensity switch. Anyone can easily apply by adjusting.

      The low-frequency conductive hydrogel patch containing the applied pain and inflammation-relieving components, as well as physical pharmacological effects due to low frequency, delivers the pharmacological components to the injured area, resulting in rapid pain-relieving and inflammation-releasing effects.

1a; Conductive hydrogel electrode patch for low frequency stimulator containing pain and inflammation relief component (anode)
1b; Conductive hydrogel electrode patch for low frequency stimulator containing pain and inflammation relief (cathode)
10; Fabric 21; wire
22; Wire covering 23; connector
30; Conductive electrode
40; Conductive hydrogel for low frequency stimulator containing pain and inflammation relief components
50; Release paper
60; Fabrics 70a, 70b; Positive and negative snap
80a, 80b; Anode, cathode conductive electrode
90a, 90b; Conductive hydrogel for low frequency stimulator containing pain and inflammation relief components
100; Release paper

Claims (6)

Low frequency stimulator designed to deliver low frequency treatment to the contact surface of human body by generating low frequency when used in connection with low frequency oscillator, and to deliver drugs of pain relieving agents and anti-inflammatory agents to skin, such as neuralgia, muscle pain, menstrual pain, bruise As the electrode patch, snaps 70a and 70b which can be connected to the low frequency oscillators shown in Figs. 2 and 4 and the wires 20 and 21 or the terminal 22 of the connector type, the electrode protection fabric 60 and the conductive electrode ( Conductive film 80a or conductive ink coating 80b on the film), conductive hydrogels 90a and 90b for low frequency stimulators that can be connected by attachment between electrodes and treatment sites, and release paper 100 to protect conductive hydrogels. Consisting of the low-frequency stimulator for conducting low-frequency stimulator containing a pain and inflammation-releasing component, characterized in that it contains a pain and inflammation relief component in the conductive hydrogel The hydrogel patch electrode.
The terminal connecting to the low frequency oscillator in claim 1 is configured to connect the positive and negative wires from the low frequency stimulator unit by a connector or a snap terminal method depending on the patch, and the pain and inflammation formed between the fabric and the conductive electrode. Conductive hydrogel electrode patch for low frequency stimulator containing relaxation components.
The electrode protective fabric of claim 1 may be composed of one or two or more of a nonwoven fabric, a polyurethane, a nonwoven fabric and a polyurethane blend, polyethylene film, OPP film or polymer fiber, and the like Conductive hydrogel electrode patch for low frequency stimulator containing a pain and inflammation relief component disposed on the conductive electrode to fix the snap, so that current is not directly applied to the human body through the conductive electrode.
The conductive electrode for a low frequency stimulator of claim 1 may be composed of an anisotropic conductive film such as carbon, silver chloride, tin chloride, or platinum metal, or may be formed by coating a conductive ink such as carbon or silver chloride on one side of the electrode protective fabric. The low frequency stimulator is connected to the conductive electrode when the wire and connector method or the snap method is applied so that a low frequency signal can be transmitted from the low frequency stimulator to the conductive hydrogel containing the pain and inflammation relief component when the current is applied. A conductive hydrogel electrode patch for a low frequency stimulator containing pain and inflammation relief components disposed between the conductive electrode and the conductive hydrogel so as to be able to.

The conductive hydrogel for low frequency stimulator containing the pain and inflammation-releasing component according to claim 1 is a N-vinyllactam monomer or vinyl monomer or a vinyl monomer such as sodium, potassium, calcium salt, sulfonic acid and It is not limited to one of these monomers with an amine group, and is composed of 5.0 to 40.0% by weight of the total weight of the hydrogel, and has a vinyl group, an acrylic group, a methacrylate group or more as a crosslinking agent, and a hydrogel. It is composed of 0.05 ~ 2.0% by weight of the total weight, the photoinitiator and thermal initiator is composed of 0.01 ~ 1.0% by weight of the total weight of the hydrogel as a polymerization initiator, ionic such as sodium cations, calcium cations, potassium cations as an electrolyte The compound is comprised in the range of 0.1 to 10.0% by weight of the total weight of the hydrogel, and is a polyacrylic acid polymer, polyacrylic acid and a salt as a thickener. Copolymer, polyethylene oxide, polyvinylpyrrolidone, polyvinyl alcohol, polyvinylpyrrolidone and polyvinyl alcohol copolymer, carboxymethyl cellulose and its salts, carbomer, gantrez, hydroxymethyl cellulose, hydroxy Ethyl cellulose, poloxamer, methyl cellulose, ethyl cellulose, hydroxypropyl methyl cellulose, corn protein extract, hydroxypropyl methyl cellulose phthalate, pullulan, gelatin, eudragit, agar, carrageenan, pectic, gum (xanthan, guar, Locust bean, Arabia, cassia, tara, tragacanth, etc.), starch, at least one selected from the group consisting of 1.0 to 5.0% by weight of the total weight of the hydrogel, glycerin, propylene glycol, Butylene glycol, Sorbitol, Polyethylene glycol, Polypropylene glycol, Pentadiol, Pentaerythrite Polyhydric alcohols such as tall, triglycerol, and trimethol propane contain 0.5 to 40% by weight of the total weight of the hydrogel, and purified water contains 10.0 to 60.0% by weight of the total weight of the hydrogel. And menthol, menthyl lactate, other menthol derivatives, peppermint oil, red pepper extract, capsaicin, gardenia extract, and vigor, which are anti-irritants of warmth, are not limited to one or more of these, and contain 0.1 to 5.0% by weight of the total weight of the hydrogel. Inflammation-releasing ingredients include glycol salicylate, methyl salicylate, indomethacin, ibuprofen, ketoprofen, flurbiprofen, felbinac, pyricampam, camphor, diphenhydramine, glycyrrhizin acid, licorice extract , Achinacea extract, Portulaca oleracea extract, Munjuran extract, Sulfur, Gold and Silver Coin extract, Longunder, Angelica extract, Turmeric extract, Safflower extract, Corydalis extract, Changsha Extract It not limited from the group consisting of one or a mixture of two or more of these in, contains 0.1-5.0% by weight of the total weight of the hydrogel.
The conductive hydrogel for the low frequency stimulator containing the pain and inflammation-relieving component is disposed on the conductive electrode layer, so that the electric current generated from the low frequency stimulator when the body is attached to the low frequency stimulator is connected to the low frequency stimulator through the wire and the connector and the conductive electrode or the snap and the conductive electrode. Conductive hydrogel electrode patch for low-frequency stimulator containing pain and inflammation-releasing component is configured to deliver a pharmacological component and low-frequency signal to the pain and inflammation site through the hydrogel to have a therapeutic effect.
   The release paper of claim 1 protects the conductive hydrogel until use, and may be used a polyester film or paper coated with silicon to facilitate peeling during use, in addition to polyethylene film that can be easily peeled off. The release paper is a pain and inflammation relief component disposed on the low-frequency stimulator-conductive hydrogel containing the pain and inflammation-releasing component to protect the conductive hydrogel layer for the low-frequency stimulator containing the pain and inflammation-releasing component until the product is used. Conductive hydrogel electrode patch for low frequency stimulator containing.

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