KR101166481B1 - 목단피 추출물을 함유하는 파킨슨병 예방 및 치료용 조성물 - Google Patents
목단피 추출물을 함유하는 파킨슨병 예방 및 치료용 조성물 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/322—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
Description
MCR: 목단피(Moutan Cortex Radicis ) 추출물;
MPTP: 1-메틸-4-페닐-1,2,3,6-테트라하이드로피리딘(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine); 및
Levodopa: L-다이하이드록시페닐알라닌(L-3,4-dihydroxyphenylalanine, L-DOPA).
도 2는 선조체 내 타이로신 하이드록실레이즈(Tyrosine hydroxylase)의 면역 반응 변화를 관찰한 그림이다:
A: 대조군으로 식염수가 투여군;
B: MPTP 투여군;
C: 50 ㎎/㎏ 목단피 추출물 투여군;
D: 100 ㎎/㎏ 목단피 추출물 투여군; 및
E: 15 ㎎/㎏ L-다이하이드록시페닐알라닌 투여군.
도 3은 MPTP로 유도한 파킨슨 동물모델에서 목단피 추출물의 흑질내 도파민 신경세포의 보호 효과를 측정하기 위한 그림이다:
도 3의 1은 MPTP로 유도한 파킨슨 동물모델에서 목단피 추출물의 MPTP로 유도된 흑질내 도파민 신경세포의 보호 효과를 면역염색법으로 관찰한 그림이다;
A: 대조군으로 식염수가 투여군;
B: MPTP 투여군;
C: 50 ㎎/㎏ 목단피 추출물 투여군;
D: 100 ㎎/㎏ 목단피 추출물 투여군;
E: 15 ㎎/㎏ L-다이하이드록시페닐알라닌 투여군;
도 3의 2는 MPTP로 유도한 파킨슨 동물모델에서 면역염색법으로 관찰한 목단피 추출물의 흑질내 도파민 신경세포의 보호 효과를 그래프로 나타낸 그림이다;
con: 대조군(식염수 투여군);
MPTP: 1-메틸-4-페닐-1,2,3,6-테트라하이드로피리딘 투여군;
MCR(50): 50 ㎎/㎏ 목단피 추출물 투여군;
MCR(100): 100 ㎎/㎏ 목단피 추출물 투여군;
***: 대조군에 비하여 p < 0.001 ; 및
##: MPTP군에 비하여 p < 0.001.
도 4는 MPTP로 유도한 파킨슨 동물모델에서 목단피 추출물의 선조체 내 도파민 함량의 변화를 측정하기 위한 그림이다:
con: 대조군(식염수 투여군);
MPTP: 1-메틸-4-페닐-1,2,3,6-테트라하이드로피리딘 투여군;
MCR(50): 50 ㎎/㎏ 목단피 추출물 투여군;
MCR(100): 100 ㎎/㎏ 목단피 추출물 투여군;
L-Dopa: 15 ㎎/㎏ L-다이하이드록시페닐알라닌 투여군; 및
***: 대조군에 비하여 p < 0.001.
도 5는 MPTP로 유도한 파킨슨 동물모델에서 목단피 추출물의 선조체 내 도파민 대사산물인 DOPAC 함량의 변화를 측정하기 위한 그림이다:
con: 대조군(식염수 투여군);
MPTP: 1-메틸-4-페닐-1,2,3,6-테트라하이드로피리딘 투여군;
MCR(50): 50 ㎎/㎏ 목단피 추출물 투여군;
MCR(100): 100 ㎎/㎏ 목단피 추출물 투여군;
L-Dopa: 15 ㎎/㎏ L-다이하이드록시페닐알라닌; 및
*: 대조군에 비하여 p < 0.05.
도 6은 MPTP로 유도한 파킨슨 동물모델에서 목단피 추출물의 도파민 신경세포의 손상 정도를 iNOS 발현을 통해서 확인한 그림이다:
도 6의 1은 목단피 추출물의 MPTP로 유도된 도파민 신경세포의 손상 정도를 측정하기 위한 지표로 iNOS 발현량을 웨스턴 블랏으로 관찰한 그림이다;
도 6의 2는 목단피 추출물의 MPTP로 유도된 도파민 신경세포의 손상 정도를 측정하기 위한 지표로 웨스턴 블랏으로 관찰된 iNOS 발현량을 광학밀도를 통해서 분석한 그래프이다;
con: 대조군(식염수 투여군);
MPTP: 1-메틸-4-페닐-1,2,3,6-테트라하이드로피리딘 투여군;
MCR(50): 50 ㎎/㎏ 목단피 추출물 투여군;
MCR(100): 100 ㎎/㎏ 목단피 추출물 투여군;
L-Dopa: 15 ㎎/㎏ L-다이하이드록시페닐알라닌;
*: 대조군에 비하여 p < 0.01;
#: MPTP군에 비하여 p < 0.01; 및
###: MPTP군에 비하여 p < 0.001.
도 7은 MPTP로 유도한 파킨슨 동물모델에서 목단피 추출물의 도파민 신경세포의 손상 정도를 cox-2 발현을 통해서 확인한 그림이다:
도 7의 1는 MPTP로 유도한 파킨슨 동물모델에서 목단피 추출물의 도파민 신경세포의 손상 정도를 측정하기 위한 지표로 cox-2 발현량을 웨스턴 블랏으로 관찰한 그림이다;
도 7의 2는 MPTP로 유도한 파킨슨 동물모델에서 목단피 추출물의 도파민 신경세포의 손상 정도를 측정하기 위한 지표로 웨스턴 블랏으로 관찰된 cox-2 발현량을 광학밀도를 통해서 분석한 그래프이다;
con: 대조군(식염수 투여군);
MPTP: 1-메틸-4-페닐-1,2,3,6-테트라하이드로피리딘 투여군;
MCR(50): 50 ㎎/㎏ 목단피 추출물 투여군;
MCR(100): 100 ㎎/㎏ 목단피 추출물 투여군; 및
L-Dopa: 15 ㎎/㎏ L-다이하이드록시페닐알라닌;
*: MPTP군에 비해서 p < 0.01;
#: 대조군에 비해서 p < 0.01; 및
##: 대조군에 비해서 p < 0.001.
Claims (5)
- 물, C1 내지 C4의 저급 알코올 또는 이들의 혼합물로 추출한 목단피 추출물을 유효성분으로 함유하는 파킨슨병 예방 및 치료용 조성물.
- 삭제
- 제 1항에 있어서, 상기 저급 알코올은 에탄올 또는 메탄올인 것을 특징으로 하는 파킨슨병 예방 및 치료용 조성물.
- 물, C1 내지 C4의 저급 알코올 또는 이들의 혼합물로 추출한 목단피 추출물을 유효성분으로 함유하는 파킨슨병 예방 및 개선용 건강식품.
- 제 4항에 있어서, 상기 저급 알코올은 에탄올 또는 메탄올인 것을 특징으로 하는 파킨슨병 예방 및 개선용 건강식품.
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KR20210042837A (ko) | 2019-10-10 | 2021-04-20 | 엠테라파마 주식회사 | 원화, 위령선, 및 천마의 복합 생약 추출물을 포함하는 신경퇴행성 질환의 예방 또는 치료용 조성물 |
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