KR101125482B1 - Composition for preventing and treating nose disease comprising extract of Star anis and aroma oil as active ingredients - Google Patents

Abstract

The present invention relates to an inhalable natural fragrance having an effect on the antimicrobial and respiratory diseases including a large number of plant extracts of the East and West, and more specifically, to the octagonal extract, various herbal extracts and various natural aromatic oils. It relates to a composition for preventing and treating nasal diseases and an antimicrobial composition comprising a mixture as an active ingredient. The composition of the present invention is an optimal antimicrobial natural aromatic herbal aroma material that protects the respiratory organs from microorganisms and prevents nasal congestion and kokol improves respiratory diseases of rhinitis and clears the head. Inhaled by spraying, etc., if properly mixed, the freshness of the odor and antimicrobial action, nasal congestion, snoring, rhinitis, various respiratory diseases to improve the effectiveness is very high.

Octagonal, Aroma, Nasal Disease, Rhinitis, Antibacterial

Description

Composition for preventing and treating nose disease comprising extract of Star anis and aroma oil as active ingredients}

The present invention relates to an inhalable natural aromatic substance having an effect on the antimicrobial and respiratory diseases including a large number of plant extracts of the East and the West, and more particularly, the extract of Octagon and various herbal ingredients and various natural aromatic oils. It relates to a composition for preventing and treating nasal diseases and an antimicrobial composition comprising a mixture containing the compound as an active ingredient.

The human nose regulates 10,000 to 20,000 liters of air per day, filtering and extinguishing numerous infectious agents, antigens and toxins. The nose is also a very sensitive area, so there are a number of causes that can easily block your nose. In this case, the oxygen supply to the head is not smooth enough to interfere with the brain, nervous and irritable to affect a lot of daily life. The respiratory tract is the primary route of infection. As respiratory diseases caused by bacterial and viral environmental pollution gradually increase, there has been a need for drugs that can effectively protect the respiratory organs from infectious agents and effectively cure the diseases.

Octagon (Star anis) is a spice and herbal medicine widely used in Guangxi, Guangdong, Yunnan, China, and is used as a material for Tamiflu, which is known to be effective against swine flu. And essential oils of saprol (C10H10O2) and anisik ketone (C10H12O2). It has been used mainly as a food flavoring agent, and several pharmacological effects, including anticancer and antimicrobial effects, have been reported.

Among the many medical effects that essential oils have in common, bactericidal preservatives are of particular interest to modern people. In addition, because essential oils have a strong volatility, volatile odor particles flow through the nose and lungs, and easily evaporate oxygen molecules they have and release those oxygen molecules to form ozone and anions bacteria, viruses, and fungi It creates a clean environment in which your back can't live and protects and stabilizes your respiratory tract, as well as refreshing and clearing your head.

It is known that Mokyang, Angelica, Gamuk, Creation, and Seokchangpo have the effects of immunity, nerve stability, and antibacterial activity. Dandelion and Echochocho are strong antibacterial and detoxification effects, and have excellent effects on respiratory diseases. .

In general, a number of antimicrobials, antibiotics and antivirals have been developed and are still under development. It is also known that these compounds cause side effects or resistant bacteria in the human body. This is a reality that needs to be replaced by natural substances.

Octagonal or aromatic herbal medicines and aroma oils are used as fragrances or antimicrobial agents, respectively, but the characteristics are inhalable, or the effect of inhalation is not as expected.

Therefore, the present inventors have studied to develop a new composition that is effective in antibacterial or nasal diseases such as nasal congestion, snoring, and rhinitis. As a result, the mixed composition of various aromatic herbs and natural aromatic oils, including octagons, is excellent. And confirmed that the effect on the nasal disease has completed the present invention.

Therefore, the present invention utilizes plant extracts of East and West plants such as spices, herbal medicines, essential oils, etc., having stability against the human body and natural antimicrobial ability to solve the above problems, inhaled in the respiratory use, increase the satisfaction level of the odor and clinically It is aimed at producing optimal mixtures with simultaneous improvement in potency and stability.

For the problem to be solved as described above, the composition for preventing and treating nasal diseases selected from the group consisting of nasal congestion, snoring and rhinitis according to the present invention, octagonal 2 to 4 parts by weight, 6 to 8 parts by weight of the country, creation 2-4 parts by weight, 4-6 parts by weight of Mok Hyang, 4-6 parts by weight of Angelica, 4-6 parts by weight of Seokchangpo, 2-4 parts by weight of Echo vinegar, 4-6 parts by weight of Dandelion, and extract the aromatic herbal medicine extract; An aromatic oil mixture comprising eucalyptus oil, tea tree oil, lavender oil, peppermint oil and lemon oil in a volume ratio of 500: 200: 100: 50: 200; It is characterized by mixing in a weight ratio of 30: 1.

As another embodiment of the present invention, the antimicrobial composition is 8 to 8 parts by weight, 8 to 8 parts by weight, 8 to 4 parts by weight, 8 to 4 parts by weight, 4 to 6 parts by weight, 4 to 6 parts by weight, Angelica 4 Aromatic herbs extract extracted by mixing in a ratio of 6 to 6 parts by weight, Eoseongcho 2 to 4 parts by weight, dandelion 4 to 6 parts by weight; An aromatic oil mixture comprising eucalyptus oil, tea tree oil, lavender oil, peppermint oil and lemon oil in a volume ratio of 500: 200: 100: 50: 200; It is characterized by mixing in a weight ratio of 30: 1.

Hereinafter, the present invention will be described in detail.

The composition of the present invention is 2 to 4 parts by weight octagonal, 6 to 8 parts by weight of persimmon soup, 2 to 4 parts by weight, 4 to 6 parts by weight of Mokyang, 4 to 6 parts by weight, Angelica 4 to 6 parts by weight, 4 to 6 parts by weight of Seokcho 1 part by weight of an aromatic oil mixture comprising 4 parts by weight, 30 parts by weight of a mixed extract of dandelion 4-6 parts and 500 μl of eucalyptus oil, 200 μl of tea tree oil, 100 μl of lavender oil, 50 μl of peppermint oil, 200 μl of lemon oil The main ingredient of the mixture is effective in nasal diseases such as nasal congestion, snoring and rhinitis, and has excellent antibacterial activity.

The composition of the present invention can be prepared by mixing the aromatic herbal extracts such as octagonal and aroma oil mixed solution in a weight ratio of 30: 1.

Herbal extract of the composition of the present invention can be prepared by a solvent extraction method known in the art. For example, using any one selected from alcohols having 1 to 6 carbon atoms such as water, ethanol and methanol, organic solvents such as acetone, ethyl acetate, n-nucleic acid, diethyl ether, acetone, benzene, or a mixed solvent thereof. Can be extracted. Preferably, the extraction may be performed using water or an alcohol having 1 to 6 carbon atoms. When the extract is prepared by the solvent extraction method, hot water extraction, ultrasonic extraction and reflux extraction may be used. Most preferably, the extract of the present invention may be prepared by a hot water extraction method using water as a solvent.

The temperature during extraction is preferably performed at room temperature under atmospheric pressure and the extraction time depends on the extraction temperature, but is extracted from 1 hour to 6 hours, preferably 2 hours to 4 hours. In addition, the extraction efficiency can be further increased when stirring with a shaker (shaker) during extraction.

Each herb used for extraction can be harvested, washed and used as is or dried. As a drying method, both dry, shade, hot air drying and natural drying can be used. In addition, in order to increase the extraction efficiency, each herbal medicine or its dry matter may be used by grinding with a grinder.

Preferred contents and efficacy of the herbal medicine contained in the composition of the present invention are shown in Table 1 below.

The aroma oil included in the composition of the present invention may be an aromatic oil mixture including 500 μl of eucalyptus oil, 200 μl of tea tree oil, 100 μl of lavender oil, 50 μl of peppermint oil, 200 μl of lemon oil, and each of the aroma oils includes From the extracting material, it may be prepared according to an oil extraction method known in the art, or a commercial one may be used.

Preferred contents and efficacy of the aromatic oil contained in the composition of the present invention are shown in Table 2 below.

The composition of the present invention has the effect of preventing or treating nasal diseases. Nasal diseases may be nasal congestion, snoring or rhinitis.

The composition of the present invention may be formulated with a suitable carrier depending on the route of administration. It may preferably be formulated as an inhalation agent in the form of a spray formulation.

In the case of inhaled dosages, the compositions of the present invention can be used in combination with a suitable propellant, for example, dichlorofluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas, to aerosol from a pressurized pack or nebulizer. It can be delivered conveniently in the form of a spray. In the case of a pressurized aerosol, the dosage unit can be determined by providing a valve to deliver a metered amount. For example, gelatin capsules and cartridges for use in an inhaler or insufflator may be formulated to contain a compound, and a powder mixture of a suitable powder base such as lactose or starch.

Other pharmaceutically acceptable carriers can be found in Remington's Pharmaceutical Sciences, 19th ed., Mack Publishing Company, Easton, Pa., 1995).

In addition, the pharmaceutical compositions according to the invention may comprise one or more buffers (e.g. saline or PBS), carbohydrates (e.g. glucose, mannose, sucrose or dextran), antioxidants, bacteriostatic agents, chelating agents (Eg, EDTA or glutathione), adjuvants (eg, aluminum hydroxide), suspending agents, thickening agents, and / or preservatives.

In addition, the compositions of the present invention may be formulated using methods known in the art so as to provide rapid, sustained or delayed release of the active ingredient after administration to the mammal.

Therefore, the composition of the present invention is an optimal antimicrobial natural aromatic herbal aroma substance that protects the respiratory organs from microorganisms and prevents nasal congestion and kokol improves respiratory diseases of rhinitis and clears the head. By properly injecting oil and inhaling it with a spray, etc., it is said to be very effective due to the refreshing effect of the odor and antibacterial action, nasal congestion, snoring, and improvement of various respiratory diseases of rhinitis.

Below. The present invention will be described in detail by way of examples.

However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.

<Example 1>

Preparation of Natural Herbal Aroma Mixtures

Octagonal 3g, Gamuk 7g, Creation 3g, Mokhyang 5g, Angelica 5g, Seokchangpo 5g, Eoseongcho 3g, Dandelion 5g, crushed and blended, left at room temperature for 10 hours to simmer, and heated again for 30 minutes Prepared.

To prepare a composition of the present invention by adding an aromatic oil mixture of 500 μl of eucalyptus oil, 200 μl of tea tree oil, 100 μl of lavender oil, 50 μl of peppermint oil, and 200 μl of lemon oil, the composition of the present invention was added. Formulated in form.

<Experimental example 1>

Sample Preparation and Antimicrobial Absorbance Measurement

A sample was prepared by adding 3 ml of the liquid medium and the composition of Example 1 to the test tube. E. coli (Escherichia coli) was inoculated onto the sample and the absorbance was measured after 2 days of incubation at 37 ℃.

As a result, as shown in Table 3, it was found that when the composition of the present invention is added, E. coli proliferation is suppressed to have an antimicrobial activity. In particular, the composition of the present invention, that is, natural herbal aroma mixture solution was found that the antimicrobial effect is better than when using the herbal medicine extract mixture (herbal mixture) and aroma oil separately.

<Experimental example 2>

Fragrance Satisfaction and Clinical Evaluation

For the natural herbal aroma spray prepared above, 10 people were evaluated, and the average age group was 34 years old. Inhalation was carried out directly in the nose using a spray under the condition of 20 ° C. The satisfaction satisfaction survey was conducted (based on 5 points; the higher the score, the more positive). The results are shown in Table 4.

In addition, the herbal herbal aroma spray prepared above was directly inhaled into the nose of 10 males with symptoms of Cokol, 10 volunteers with nasal congestion, and 10 rhinitis patients. The results are shown in Table 6 (1 point: no effect at all; 2 points: some effects; 3 points: some effects; 4 points: good effects; 5 points: very effective).

As a result, as shown in Table 5, it can be seen that the composition of the present invention refreshes the mood and has a significant effect on respiratory diseases. Therefore, it is expected to have a significant effect on colds and influenza.

As described above, the composition of the present invention is an optimal antimicrobial natural aromatic herbal aroma material that protects the respiratory organs from microorganisms and prevents nasal congestion and Cocoul's respiratory disease of rhinitis and clears the head. Field, aroma oils by appropriately inhaled by spray, etc., the freshness of the odor and antimicrobial action, nasal congestion, snoring, rhinitis, various respiratory diseases to improve the effectiveness is very high.

Claims (4)

Octagonal 2 to 4 parts by weight, 6 to 8 parts by weight of persimmon soup, 2 to 4 parts by weight, 4 to 6 parts by weight of Mokyang, 4 to 6 parts by weight of Angelica, 4 to 6 parts by weight of Seokchangpo, 2 to 4 parts by weight of Echo Aromatic herb extract extracted by mixing at a ratio of 4 to 6 parts by weight; An aromatic oil mixture comprising eucalyptus oil, tea tree oil, lavender oil, peppermint oil and lemon oil in a volume ratio of 500: 200: 100: 50: 200; A composition for preventing and treating nasal diseases selected from the group consisting of nasal congestion, snoring and rhinitis mixed in a weight ratio of 30: 1. Octagonal 2 to 4 parts by weight, 6 to 8 parts by weight of persimmon soup, 2 to 4 parts by weight, 4 to 6 parts by weight of Mokyang, 4 to 6 parts by weight of Angelica, 4 to 6 parts by weight of Seokchangpo, 2 to 4 parts by weight of Echo Aromatic herb extract extracted by mixing at a ratio of 4 to 6 parts by weight; An aromatic oil mixture comprising eucalyptus oil, tea tree oil, lavender oil, peppermint oil and lemon oil in a volume ratio of 500: 200: 100: 50: 200; Antimicrobial composition mixed in a weight ratio of 30: 1. delete A spray formulation comprising the composition of claim 1.