KR101055666B1 - 자연 살해 t 세포의 리간드와 항원을 적재한 단핵구 또는 미분화 골수성 세포를 포함하는 백신 - Google Patents
자연 살해 t 세포의 리간드와 항원을 적재한 단핵구 또는 미분화 골수성 세포를 포함하는 백신 Download PDFInfo
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- KR101055666B1 KR101055666B1 KR1020100099443A KR20100099443A KR101055666B1 KR 101055666 B1 KR101055666 B1 KR 101055666B1 KR 1020100099443 A KR1020100099443 A KR 1020100099443A KR 20100099443 A KR20100099443 A KR 20100099443A KR 101055666 B1 KR101055666 B1 KR 101055666B1
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Abstract
Description
도 2는 αGalCer를 적재하고 항원을 발현하는 아데노바이러스로 형질 도입된 단핵구 백신의 항암 효과를 나타낸 도이다.
도 3은 αGalCer와 항원 펩티드가 함께 적재된 IMC 백신의 항암효과를 나타낸 도이다.
도 4는 αGalCer를 적재하고 항원을 발현하는 아데노바이러스로 형질 도입된 IMC 백신의 항암 효과를 나타낸 도이다.
도 5는 IMC 백신에 의한 항암 효과를 나타내는 면역세포를 확인한 결과를 나타낸 도이다:
a: NK 세포 제거; 및,
b: CD4 또는 CD8 세포 제거.
도 6은 αGalCer와 항원 펩티드가 함께 적재된 단핵구 백신에 의한 항원 펩티드 특이적인 세포 독성 T 림프구의 활성을 나타낸 도이다.
도 7은 αGalCer와 항원 펩티드가 함께 적재된 단핵구 백신의 용량별 항원 펩티드 특이적인 세포 독성 T 림프구의 활성을 나타낸 도이다.
도 8은 αGalCer를 적재하고 항원을 발현하는 아데노바이러스로 형질 도입된 단핵구 백신에 의한 항원 특이적인 세포 독성 T 림프구의 활성을 나타낸 도이다.
도 9는 αGalCer와 항원 펩티드가 함께 적재된 IMC 백신의 용량별 항원 펩티드 특이적인 세포 독성 T 림프구의 활성을 나타낸 도이다.
도 10은 αGalCer와 항원 펩티드가 함께 적재된 IMC 백신에 의한 항원 펩티드 특이적인 세포 독성 T 림프구의 활성을 나타낸 도이다.
도 11은 αGalCer를 적재하고 항원을 발현하는 아데노바이러스로 형질 도입된 IMC 백신의 용량별 항원 펩티드 특이적인 세포 독성 T 림프구의 활성을 나타낸 도이다.
도 12는 αGalCer를 적재하고 항원을 발현하는 아데노바이러스로 형질 도입된 단핵구 백신에 의해 유도되는 항원 특이적인 항체 반응을 나타낸 도이다.
도 13은 αGalCer와 OT-1 항원 펩티드가 함께 적재된 IMC 백신의 항원 펩티드 특이적인 세포 독성 T 림프구의 활성을 나타낸 도이다.
Claims (9)
- CD1d 분자에 알파-갈락토실세라마이드, 알파-글루쿠로노실세라마이드, 포스파티딜이노시톨테트라만노사이드, 이소글로보트리헥소실세라마이드, 갱글리오사이드 GD3, 포스파티딜콜린, 포스파티딜에탄올아민, 포스파티딜이노시톨, 설파타이드, 베타-갈락토실세라마이드, 리포포스포글리칸, 글리코이노시톨 포스포리피드, 알파-갈락토실세라마이드의 유사체인 베타-아노머 갈락토실세라마이드 및 알파-아노머 갈락토실세라마이드, 박테리아 지질 항원으로 이루어진 군으로부터 선택되는 것 중의 어느 하나가 적재되고, MHC 분자에 병원균(pathogenic bacteria), 바이러스 및 기생충을 포함하는 병원체(pathogen) 유래의 항원 또는 암 항원이 적재된 단핵구(monocyte)를 포함하는 면역 치료 및 예방용 백신.
- 삭제
- 삭제
- 제 1항에 있어서, 병원균 유래의 항원은 백일해균(Bordetella pertussis) 항원(pertussis toxin, filamentous haemagglutinin, pertactin), 파상풍균 항원(tetanus toxoid), 디프테리아균(diphtheria) 항원(diphtheria toxoid), 헬리코박터파이로리(Helicobacterpylori) 항원(capsula polysaccharides of serogrup A, B, C, Y 및 W-135), 폐렴균(pneumococcal) 항원(Streptococcus pnemoniae type 3 capsular polysaccharide), 결핵균(tuberculosis) 항원, 콜레라(cholera) 항원(cholera toxin B subunit), 포도상구균(staphylococcal) 항원(staphylococcal enterotoxin B), 적리균(shigella) 항원(shigella polysaccharides), 보렐리아(Borrelia sp.) 항원, 칸디다(Candida albicans) 항원 및 플라스모디움(Plasmodium) 항원으로 구성된 군으로부터 선택되는 것을 특징으로 하는 면역 치료 및 예방용 백신.
- 제 1항에 있어서, 바이러스 유래의 항원은 인플루엔자 바이러스(influenza virus) 항원(haemagglutinin 및 neuraminidase 항원), 인간 파필로마 바이러스(human papilloma virus, HPV) 항원(glycoprotein), 소수포성 입안염 바이러스(vesicular stomatitis virus) 항원(vesicular stomatitis virus glycoprotein), 사이토메갈로바이러스(cytomegalovirus, CMV) 항원, 간염(hepatitis)바이러스 항원(hepatitis A(HAV), B(HBV), C(HCV), D(HDV) 및 G(HGV) 항원)(core antigen and surface antigen), 호흡기 다핵체 바이러스(respiratory synctytial virus, RSV) 항원, 허피스 심플렉스 바이러스(herpes simplex virus) 항원, 인간 면역결핍 바이러스(human immunodeficiency virus, HIV) 항원(GP-120, GP-160, p18, Tat, Gag, Pol, Env) 및 그의 조합으로 이루어진 군으로부터 선택되는 것을 특징으로 하는 면역 치료 및 예방용 백신.
- 제 1항에 있어서, 암항원은 Her-2/neu에 의해 발현되는 유방암 단백질, Proteinase 3, WT-1, 뮤리노글로브린(MUC-1), PAP, PSA, PSMA, G250, 멜라노마 항원 유전자(MAGE, melanoma antigen gene), BAGE, GAGE, NY-ESO-1, 티로시나제(tyrosinase), 티로시나제-관련 단백질-1(TRP-1), TRP-2, gp100, MART-1, MCIR, Ig Idiotype, CDK4, caspase-8, β-catenin, CIA, BCR/ABL, 인간 유두종 바이러스(HPV E6/E7), EBV LMP2a, HCV, HHV-8, 5T4, 암 배아항원(CEA: carcinoembryonic antigen), p53 및 알파-페토프로테인(α-fetoprotein)으로 이루어진 군으로부터 선택되는 것을 특징으로 하는 면역 치료 및 예방용 백신.
- 제 1항에 있어서, 상기 항원은 재조합 바이러스에 의해 도입되어 발현되는 것을 특징으로 하는 면역 치료 및 예방용 백신.
- 제 7항에 있어서, 상기 재조합 바이러스는 항원을 발현하는 유전자가 도입된 아데노바이러스, 레트로바이러스, 백시니아 바이러스, 폭스 바이러스, 신드비스 바이러스(Sindbis virus)인 것을 특징으로 하는 면역 치료 및 예방용 백신.
- CD1d 분자에 알파-갈락토실세라마이드가 적재되고 MHC 분자에 항원이 적재된 단핵구를 포함하는 항암제.
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