KR101029255B1 - Device of centrifugal separation - Google Patents

Abstract

PURPOSE: A device of centrifugal separation is provided to prevent the infection according to a mobile history of the blood by collecting the blood from patients using one injector. CONSTITUTION: A device of centrifugal separation comprises a barrel(110), plunger(120) and coupling member(200). A nozzle is formed at one end of the barrel. The plunger is housed inside the barrel and enables linear movement at the other end. A coupling hole(122) is formed In the plunger. The coupling member is selectively coupled with the coupling hole.

Description

Centrifugal Separator {DEVICE OF CENTRIFUGAL SEPARATION}

The present invention relates to a centrifugal separator, and more particularly, to a centrifugal separator capable of more quickly and simply centrifuging an object to be treated using a syringe and effectively restraining the movement of the plunger relative to the barrel. .

In general, blood is classified into blood cells, which are solid components, and plasma, which is a liquid component. Blood cells are composed of red blood cells, white blood cells and platelets, and the plasma is mainly composed of water, including blood clotting factors, electrolytes, and the like essential for life support.

As described above, the blood is a mixture of various components, and the process of extracting specific components by separating the blood for various medical purposes is widely used. Among them, the blood centrifugation process using a centrifuge and the process using a specific composition are used. It is widely used.

Among these, the centrifugation process of blood refers to a process of performing interlayer separation using the difference in weight of each component constituting the blood by rotating the blood at a constant speed, and when the blood is centrifuged, the heaviest red blood cells are formed in the lower layer ( Outer layer), from which a layer of leukocytes, plasma and serum is formed.

On the other hand, PRP (Platelet Rich Plasma: Platelet Enriched Plasma) in the plasma is relatively located in the lower plasma, and is easily used during surgery because it is involved in blood coagulation or hemostatic action. In addition, PRP contains growth factors such as cytokines, PDCF, TGF-BETA1, and VEGP, which have been shown to have good effects on skin diseases and wound healing, according to the paper.

However, conventionally, the extraction process of extracting a specific component such as platelets from the blood is cumbersome and inconvenient.

In other words, according to the centrifugation process of blood, which is widely used, red blood cells can be centrifuged through a single centrifugation process. Can be extracted by centrifugation again. Therefore, in order to extract platelets, at least two different centrifugation spaces have to be subjected to a centrifugation process, respectively, which is inconvenient and hassle-free. have.

In addition, conventionally, the time required for the separation process of a specific blood component is long, and after collecting blood from a patient, it is difficult to perform a procedure using the specific component immediately after separating a specific component such as platelets.

Accordingly, in recent years, various studies have been made on a centrifugal separation method that enables the centrifugal separation of a treatment object such as blood more quickly and simply.

The present invention provides a centrifugal separator that can more quickly and simply extract certain components from the object to be treated.

The present invention also provides a centrifugal separator that can efficiently constrain the movement of the plunger relative to the barrel. In particular, the present invention provides a centrifugal separator that can further simplify the structure for fixing the plunger to the barrel during centrifugation.

In addition, the present invention provides a centrifugal separator that can easily extract a specific component from the treatment object without external exposure or movement of the treatment object, and can prevent the deterioration and infection caused by the external exposure in advance.

In addition, the present invention can shorten the time required for the centrifugation process of the object to be treated, and provides a centrifugal separator that can directly use a specific component extracted from the object to be treated.

In addition, the present invention provides a syringe for centrifugation that can more easily separate a specific component extracted from the object to be treated.

According to a preferred embodiment of the present invention for achieving the above object of the present invention, the centrifugal separator used for extracting the target component from the object to be processed by centrifugation, at the other end of the barrel, barrel having a nozzle at one end A plunger accommodated linearly in the barrel and formed with a binding hole, and a binding member provided to be selectively coupled to the binding hole to restrain the movement of the plunger relative to the barrel.

For reference, the centrifugal separator according to the present invention can be used to centrifuge the object to be treated in various experiments and studies. In addition, the object to be treated in the present invention means a material to be subjected to various treatments by a centrifugal separator, and the present invention is not limited or limited by the type and characteristic of the object to be treated. For example, blood may be used as the object to be treated. In some cases, other samples from animals or human bodies may be used for treatment instead of blood.

Conventional syringes can be used as the barrel and plunger. For reference, in the present invention, the syringe may include other containers, devices, etc. including a first member having a hole such as a nozzle at one end thereof, and a second member provided to be linearly movable on the first member. However, various devices having a similar or identical operating structure to the syringe may be used as the syringe.

As the binding member is bound to the binding hole formed in the plunger, the movement of the plunger with respect to the barrel can be restrained. The restraint between the barrel and the plunger using the binding hole and the binding member can be changed in various ways according to the required conditions and design specifications. have. For example, a plurality of binding holes may be formed to be spaced apart along the longitudinal direction of the plunger, and the binding member may be coupled to any one of the plurality of binding holes depending on the arrangement of the plungers with respect to the barrel. In addition, the plurality of binding holes may be formed to be spaced apart from each other at uniform intervals, and may be formed to be spaced apart from each other at non-uniform intervals.

The binding member may be provided in various structures capable of binding to the binding hole. For example, the binding member may be provided in various shapes, such as pins, rods, rods, and plates, depending on the required conditions and design specifications. In addition, the binding member may be configured to simultaneously bind to a plurality of binding holes, and in some cases, the binding member may be configured to bind to only one binding hole.

In addition, the centrifugal separator may further include an adapter including a barrel seating portion on which the barrel is seated and a plunger seating portion on which the plunger is seated. The adapter may have a fixing hole corresponding to the binding hole, and the binding member may be fixed to the fixing hole by passing through the binding hole.

For reference, in the present invention, the adapter refers to an adapter that can be mounted on a rotor used in a conventional centrifuge, and the present invention is not limited or limited by the shape and structure of the adapter. For example, as a rotor to which an adapter may be mounted, a swing rotor or a fixed angle rotor, which is generally used in a centrifuge, may be used, and the present invention is limited by the type and characteristics of the rotor. It is not limited or restricted. In addition, the adapter and the rotor may be connected by a conventional accommodating or locking structure, and in some cases, the rotor and the adapter may be connected through a separate rotating bucket connected to the rotating shaft of the rotor.

In addition, the adapter may be composed of a plurality of components that can be cooperatively assembled, each component may be assembled such that the barrel and plunger is fixed by a conventional fastening member or assembly structure.

The adapter has a fixing hole corresponding to the binding hole, and the binding member may be fixed to the fixing hole while passing through the binding hole. The fixing holes may be provided to have a number and spaced interval corresponding to the binding holes, but in some cases, the fixing holes may be provided to have a different number and spaced distance from the binding holes.

On the other hand, the target component is the first centrifugal separation of the object to be processed in the barrel, and discharged through the nozzle a specific component disposed on the nozzle side by the first centrifugal separation, the nozzle direction is reversed to reverse the object to be treated in the barrel It is possible to remain inside the barrel by separating the second centrifugation and discharging through the nozzle the other specific component disposed on the nozzle side by the second centrifugation.

In the first and second centrifugation, the barrels can be arranged along various directions depending on the conditions required and the processing environment. As an example, in the first centrifugation step the barrel may be arranged such that the nozzles face outward of the center of rotation of the barrel, and in the second centrifugation step the barrel may be arranged so that the nozzles face inward of the center of rotation of the barrel. have. In some cases, it is also possible to arrange the nozzles to face the inside of the barrel's rotation center in the first centrifugation step, and to arrange the nozzles to face the outside of the barrel's rotation center in the second centrifugation step.

If the object to be treated is blood, during the first centrifugation, one of the heaviest components of blood may be disposed on the nozzle side that is the outermost inside of the barrel relative to the center of rotation of the barrel. This particular component may comprise the heaviest red blood cells among the components of the blood.

In addition, during the second centrifugation, an interlayer separation is performed between the components by the difference in the density of the remaining components (for example, plasma and platelets) constituting the blood. The specific component may be disposed on the nozzle side that is the innermost side of the barrel with respect to the center of rotation of the barrel, and such other specific component may include a relatively light plasma among the remaining components of the blood.

The barrel and plunger may be configured to always be seated in the adapter in a constant direction, but in some cases, the barrel and plunger may be configured to selectively change the direction of the barrel and plunger on the adapter. In addition, when the barrel and plunger are always seated in the adapter in a constant direction, the adapter may be mounted in an inverted state selectively with respect to a rotating means such as a rotor or a rotating bucket.

On the other hand, the binding member may be configured to be fixed directly to the barrel. For this purpose, a coupling hole may be formed in the barrel, and the binding member may be coupled to the binding hole while passing through the coupling hole. Coupling holes may be provided in various locations depending on the requirements and design specifications. For example, a support may be formed at the other end of the barrel, and the coupling hole may be formed at the support.

In addition, the binding member may be configured to bind to the binding hole in a rotational movement manner. That is, the binding member may be rotatably coupled to one end of the barrel, and selectively bound to the binding hole by rotating about one end.

In addition, it is also possible to comprise so that the position of a binding hole may be selectively changed according to the arrangement state of a plunger with respect to a barrel. That is, the movable binding unit may be provided to selectively linearly move on the plunger, and the binding hole may be formed in the movable binding unit. Therefore, the position of the binding hole on the plunger can be varied as the movable binding member moves linearly on the plunger according to the arrangement of the plunger with respect to the barrel.

In addition, the plunger may be provided with an operation unit that linearly moves on the plunger by a rotation operation, and the movable binding unit may be configured to move linearly by the operation unit. The operating portion may be provided rotatably on the plunger in various ways depending on the required conditions and design specifications. For example, the plunger may be provided with a guide screw, and the operation unit may be mounted on the guide screw and configured to linearly move along the guide screw by a rotation operation.

According to the centrifugal separator according to the present invention, it is possible to efficiently restrain the movement of the plunger relative to the barrel by using the binding member.

In particular, according to the present invention, since the arrangement of the plunger with respect to the barrel can be fixed simply by using the binding member, the structure for fixing the plunger with respect to the barrel during centrifugation can be further simplified. As well as. Even when the barrel and the plunger are mounted on an adapter, a rotor (or a rotating bucket) or the like, the arrangement of the plunger with respect to the barrel can be restrained more efficiently.

In addition, according to the present invention it is possible to implement a centrifugal separator using a conventional syringe without large changes in the structure and form of the existing syringe.

In addition, according to the present invention after extracting the blood using a syringe can be subjected to a centrifugation process directly in the syringe without having to transfer to another storage container or tube, specific components, such as platelet concentration plasma (PRP) in the syringe ) Can be directly removed and re-injected directly into the syringe without moving. Through this process, certain components can be extracted more hygienically, quickly and simply from the object to be treated.

Furthermore, according to the present invention, a primary syringe can be used with one syringe without having to expose the object to the outside or move it to another centrifugal space by using a separate means for extracting a characteristic component from the object, such as blood. And since the second centrifugation can be performed, it is possible to extract a specific component contained in the object more quickly and simply, and can be injected directly.

In addition, according to the present invention, since a specific component can be extracted from the object without external exposure or movement of the object, deterioration and infection due to external exposure can be prevented in advance.

In addition, according to the present invention can shorten the time required for the centrifugation process, it is possible to immediately use the specific components extracted from the object to be treated. For example, after collecting blood from a patient, specific components such as platelets can be isolated, and then the patient can perform the procedure using the specific components, and more effectively cope with emergencies.

In addition, according to the present invention, since the blood can be collected from the patient using one syringe and the centrifugation process can be performed, infection due to the blood migration process can be prevented, and the blood centrifugation process can be performed. It can be simplified more.

1 and 2 is a view showing the structure of a centrifugal separator according to the present invention.
3 to 5 are views for explaining the first centrifugal separation process and the discharge process using a centrifugal separator according to the present invention.
6 to 8 are diagrams for explaining a second centrifugal separation process and a discharge process as a centrifugal separation method according to the present invention.
9 is a view showing a use example of the target component extracted after the second centrifugal separator according to the present invention.
10 to 14 are views showing the structure of the centrifugal separator according to another embodiment of the present invention, respectively.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings, but the present invention is not limited or limited by the embodiments. In describing the present invention, a detailed description of well-known functions or constructions may be omitted for clarity of the present invention.

1 and 2 is a view showing the structure of a centrifugal separator according to the present invention. 3 to 5 are views for explaining the first centrifugal separation process and the discharge process using the centrifugal separator according to the present invention, and FIGS. 6 to 8 are the second centrifugal separation method according to the present invention. 9 is a view for explaining the separation process and the discharge process, Figure 9 is a centrifugal separator according to the present invention, showing a use example of the target component extracted after the second centrifugal separation.

As shown in FIG. 1, the centrifugal separator according to the present invention includes a barrel 110, a plunger 120, and a binding member 200.

For reference, the centrifugal separator according to the present invention can be used to centrifuge the object to be treated in various experiments and studies. In addition, the object to be treated in the present invention means a material to be subjected to various treatments by a centrifugal separator, and the present invention is not limited or limited by the type and characteristic of the object to be treated. Hereinafter, an example in which blood is used as the object to be treated will be described. In some cases, other samples from animals or human bodies may be used for treatment instead of blood.

The barrel 110 may be formed in a hollow cylindrical shape having a predetermined diameter (or capacity). One end of the barrel 110 is formed with a nozzle 112 for entering and exiting the treatment object, the other end of the barrel 110 is opened so that the plunger 120 can enter.

The plunger 120 enters the other end of the barrel 110 and is accommodated in the barrel 110 so as to be linearly movable, and the object to be processed through the nozzle 112 according to the pressure change caused by the linear movement of the plunger 120. Can be entered or discharged. In addition, a finger flange 114 having an extended diameter (or size) may be formed at the other end of the barrel 110. In addition, a separate insertion hole (not shown) for inserting a finger may be formed in the finger flange, and the shape and structure of the finger flange may be appropriately changed according to required conditions and design specifications.

A binding hole 122 is formed in the plunger 120, and the binding member 200 is selectively provided in the binding hole 122 so that the movement of the plunger 120 with respect to the barrel 110 may be restricted. To be able.

Constraints between the barrel 110 and the plunger 120 using the binding hole 122 and the binding member 200 may be variously changed according to required conditions and design specifications. For example, a plurality of the coupling holes 122 may be formed to be spaced apart along the longitudinal direction of the plunger 120, and the binding member 200 may be formed according to the arrangement state of the plunger 120 with respect to the barrel 110. It may be bound to any one of the plurality of binding holes 122. In addition, the plurality of binding holes 122 may be formed to be spaced apart from each other at uniform intervals, and may be formed to be spaced apart from each other at non-uniform intervals.

The binding member 200 may be provided in various structures capable of binding to the binding hole 122. For example, the binding member 200 may be provided in a variety of shapes, such as pins, rods, rods, plates, depending on the requirements and design specifications. Hereinafter, the binding member 200 will be described with an example configured to have a circular cross section and formed in a substantially "c" shape so that the binding member 200 can be simultaneously bound to two binding holes 122. In some cases, the binding member may be provided to be bound to only one binding hole.

Meanwhile, as shown in FIG. 2, the barrel 110 and the plunger 120 may be seated on the adapter 300, and the plunger 120 disposed on the adapter 300 may be fixed by the binding member 200 described above. Can be.

For reference, in the present invention, the adapter 300 refers to an adapter that can be mounted on a rotor used in a conventional centrifuge, and the present invention is not limited or limited by the shape and structure of the adapter 300. For example, as a rotor to which the adapter 300 may be mounted, a swing rotor or fixed angle rotor, which is generally used in a centrifuge, may be used, and the rotor may be viewed according to the type and characteristics of the rotor. The invention is not limited or limited. The adapter 300 and the rotor may be connected by a conventional accommodating or engaging structure, and in some cases, the rotor and the adapter may be connected through a separate rotating bucket connected to the rotating shaft of the rotor.

The adapter 300 is provided with a barrel seating portion 310 for the barrel 110 is seated. The barrel seating unit 310 may be formed to have a shape corresponding to the barrel 110, and the barrel 110 is seated on the barrel seating unit 310 so that the state of the barrel seating unit 310 may be fixed. Can be. For example, the barrel seating unit 310 may include a finger flange fixing groove 314 for accommodating the finger flange 114 of the barrel 110, and a finger flange (not shown) in the finger flange fixing groove 314. As the 114 is accommodated, the arrangement of the barrel 110 disposed in the adapter 300 may be fixed without flow.

In the above-described and illustrated embodiments of the present invention, a finger flange fixing groove for separately accommodating only the finger flange is described as an example, but in some cases, the barrel seat portion accommodates the entire barrel including the finger flange. It may be configured to.

The adapter 300 is provided with a plunger seating portion 320 for mounting the plunger 120. The plunger seating portion 320 is provided to have a size and shape that can accommodate the plunger 120, the length enough to accommodate the plunger 120 in accordance with the arrangement of the plunger 120 relative to the barrel 110 Can be provided.

In addition, the adapter 300 has a fixing hole 312 corresponding to the binding hole 122 is formed, the binding member 200 is fixed to the fixing hole 312 in a state that passed through the binding hole 122. Can be. That is, the adapter 300 may be formed to be spaced apart from the plurality of fixing holes 312 to correspond to the binding hole 122, the binding member 200 in accordance with the arrangement of the plunger 120 with respect to the barrel 110 ) Is coupled to pass through the binding hole 122 and the fixing hole 312 at the required position, thereby constraining the movement of the plunger 120 relative to the barrel 110 on the adapter 300.

Hereinafter, with reference to Figures 3 to 9, it will be described the centrifugation of blood by the centrifugal separator according to the present invention.

First, blood is stored in the barrel 110. Blood may enter the barrel 110 through the nozzle 112 according to the pressure change caused by the linear movement of the plunger 120. In this case, the blood may be equipped with a separate needle (see 132 of FIG. 9) at the tip of the nozzle 112 and may be directly supplied from the body using the needle. In some cases, it is also possible to enter the blood stored in a separate reservoir into the barrel through the nozzle.

Next, as shown in Figure 3, by using a conventional centrifuge (not shown) by rotating the adapter 300, the blood stored in the barrel 110 is centrifuged first. At this time, the barrel 110 is disposed so that the nozzle 112 faces in the opposite direction (outside) of the rotation center of the adapter 300. In addition, the rotation center of the adapter 300 may be understood as a rotation axis (not shown) of a rotating means such as a rotor or a rotating bucket in which the adapter 300 is mounted.

When the adapter 300 is rotated in a state in which the nozzle 112 of the barrel 110 is disposed so as to face the direction opposite to the rotation center of the adapter 300 as described above, as shown in FIG. Interlayer separation between the components is performed by the difference in density, wherein one specific component A, which is the heaviest among the components of blood, is the outermost side of the nozzle 112 inside the barrel 110 with respect to the center of rotation. Is placed on. For reference, the one specific component (A) may include the heaviest red blood cells among the components of the blood.

Next, the specific component (A) separated from the blood by the first centrifugal separation and disposed on the nozzle 112 side is discharged through the nozzle 112. That is, as shown in FIG. 5, the plunger 120 may be pushed out to discharge one specific component A (red blood cells) disposed on the nozzle 112 side to the outside of the barrel 110 through the nozzle 112.

Next, as shown in Figure 6, by rotating the adapter 300 through the centrifuge to separate the second centrifugal blood separated from one specific component. At this time, the barrel 110 is disposed in the opposite direction as the first centrifugal separation. That is, the barrel 110 is rotated while the nozzle 112 is disposed so as to face the rotation center of the adapter 300.

When the barrel 110 is rotated in a state where the nozzle 112 of the barrel 110 is disposed toward the rotation center of the adapter 300 as described above, as shown in FIG. 7, the remaining components constituting the blood (for example, Interlayer separation between each component is achieved by the difference in density of plasma and platelets), wherein another specific component (B), which is relatively light among the remaining components of blood, is formed inside the barrel 110 based on the center of rotation of the adapter 300. It is disposed on the nozzle 112 side that is the innermost in. For reference, the other specific component (B) may include a relatively light plasma of the remaining components of the blood.

In addition, the first centrifugal separation rate and the second centrifugal separation rate of the blood are set differently. For example, the first centrifugal separation may be performed under a condition of 2500 to 3500 rpm, and the second centrifugal separation may be performed under a condition of 4000 to 5500 rpm.

Next, the other specific component B which is separated from the blood by the second centrifugal separation and disposed on the nozzle 112 side is discharged through the nozzle 112. Similar to the one specific component described above, as shown in FIG. 8, the other specific component B (plasma) disposed on the nozzle 112 side by pushing the plunger 120 out of the barrel 110 through the nozzle 112. Can be discharged.

Therefore, after one specific component (A) and the other specific component (B) are separated and discharged from the blood through the first centrifugal separation and the second centrifugal separation, the target component (C) remaining inside the barrel 110 is platelets. (blood platelet).

As described above, only platelets may be extracted into the barrel 110 through the first centrifugation and the second centrifugation of blood, and various experiments and studies are performed using the extracted platelets, or as shown in FIG. 9, The injection using a platelet may be performed by directly injecting the patient through the needle 132 mounted on the nozzle 112.

On the other hand, Figures 10 to 14 are views showing the structure of the centrifugal separator according to another embodiment of the present invention, respectively. In addition, the same or equivalent portions as those in the above-described configuration are denoted by the same or equivalent reference numerals, and a detailed description thereof will be omitted.

In the above-described and illustrated embodiments of the present invention, an example in which the syringe is always seated in a certain direction on the adapter 300 is described. However, in some cases, the syringe may be configured to selectively change the direction of the syringe on the adapter. have.

That is, referring to FIG. 10, the centrifugal separator according to another embodiment of the present invention includes a barrel 110, a plunger 120, a binding member 200, and an adapter 300 ′, and an adapter 300 ′. The barrel seating portion 310 ', 310 ", the plunger seating portion (not shown) and the fixing hole 312' is formed, the barrel seating portion is the first barrel seating portion 310 ', and the first barrel seating And a second barrel seating portion 310 ″ provided adjacent to the first barrel seating portion 310 ′ so as to face in the opposite direction to the portion 310 ′. On the areas of the first barrel seating portion 310 'and the second barrel seating portion 310 ".

That is, the first barrel seating portion 310 ′ and the second barrel seating portion 310 ″ are provided adjacently (or closely contacted) to face in opposite directions, and the plurality of fixing holes 312 ′ and plunger seating are provided. The portion may be provided on the areas of the first and second barrel seating portions 310 ′, 310 ″. Accordingly, the barrel 110 may be seated on the first barrel seating portion 310 ′ during the first centrifugal separation, the plunger 120 may be disposed on the second barrel seating portion 310 ″, and the binding member 200 may be fixed to the fixing hole 312 ′ formed in the region of the second barrel seating portion 310 ″ through the binding hole 122. On the contrary, in the second centrifugal separation, the barrel 110 may be seated on the second barrel seating portion 310 ″, the plunger 120 may be disposed on the first barrel seating portion 310 ′, and the binding member 200 may be fixed to the fixing hole 312 ′ formed in the region of the first barrel seating portion 310 ′ through the binding hole 122.

In some cases, the first barrel seating portion and the second barrel seating portion may be spaced apart from each other at a predetermined interval, and the plunger seating portion and the fixing hole may be provided between the first barrel seating portion and the second barrel seating portion spaced apart from each other. It is also possible to configure.

Meanwhile, in the above-described and illustrated embodiments of the present invention, the binding member is fixed to the adapter, for example, but in some cases, the binding member may be configured to be directly fixed to the barrel. In this case, the syringe including the barrel and the plunger can be mounted directly to the rotating means such as the rotor and the rotating bucket without the need for a separate adapter.

That is, referring to Figure 11, the centrifugal separator according to another embodiment of the present invention, including a barrel 110, the plunger 120 and the binding member 200, the barrel 110, the coupling hole 116a ) May be formed, and the binding member 200 may be bound to the binding hole 122 while passing through the coupling hole 116a.

The coupling hole 116a may be provided at various positions according to required conditions and design specifications. For example, a support 116 may be formed at the other end of the barrel 110, and the coupling hole 116a may be formed in the support 116. In some cases, it is also possible to form a coupling hole on the barrel without a separate support.

In addition, in the above-described and illustrated embodiments of the present invention, for example, the binding member is configured to bind to the binding hole in a straight movement method, but in some cases, the binding member may be configured to be bound to the binding hole in a rotational movement method. Can be.

That is, referring to FIG. 12, the binding member 200 ′ may be rotatably coupled to the barrel 110 about one end, and may be selectively coupled to the binding hole 122 by rotating about the one end. . Hereinafter, the rotary binding member 200 ′ is provided in an approximately “L” shape and will be described by way of example, which is rotatably coupled to the finger flange 114 formed at the other end of the barrel 110. In some cases, the binding member may be configured to be rotatably coupled to other parts of the barrel, and the present invention is not limited or limited by the binding member shape and structure.

In the above-described and illustrated embodiments of the present invention, a plurality of binding holes are formed to be spaced apart from each other, and the binding member 200 may be coupled to any one of the plurality of binding holes according to the arrangement of the plunger with respect to the barrel. For example, the position of the binding hole may be selectively changed depending on the arrangement of the plunger with respect to the barrel.

Referring to FIG. 13, the centrifugal separator according to another embodiment of the present invention includes a barrel 110, a plunger 120, a binding member 200, and a movable binding unit.

The movable binding unit 140 is provided to be selectively linearly moved on the plunger 120, and the movable binding unit 140 is provided with a binding hole 142 for binding the binding member 200. By such a structure, the movable binding unit 140 can move linearly on the plunger 120 according to the arrangement state of the plunger 120 with respect to the barrel 110, so that the movable binding unit 140 moves linearly. Accordingly, the position of the binding hole 142 on the plunger 120 may vary.

In addition, the plunger 120 may be provided with an operation unit 160 that moves linearly on the plunger 120 by a rotation operation, and the movable binding unit 140 may be configured to move linearly by the operation unit 160. have.

The manipulation unit 160 may be provided to be rotatable on the plunger 120 in various ways according to the required conditions and design specifications. For example, the plunger 120 may be provided with a guide screw 150, and the operation unit 160 may be mounted on the guide screw 150 to be linearly moved along the guide screw 150 by a rotation operation. Can be.

As the guide screw 150, a conventional screw having a predetermined thread line may be used along an outer circumferential surface thereof, and the operation unit 160 is rotatably mounted along the screw line of the guide screw 150, and the guide screw is rotated. It can move linearly along 150.

By such a structure, the position of the binding hole 142 is selectively selected by rotating the operation unit 160 to move the position of the movable binding unit 140 according to the arrangement state of the plunger 120 with respect to the barrel 110. Can be varied.

In addition, a support 116 as described above may be formed at the other end of the barrel 110, and a coupling hole 116a may be formed in the support 116. Therefore, the binding member 200 may be coupled to the binding hole 142 of the movable binding unit 140 in a state where the coupling member 200 passes through the coupling hole 116a.

In addition, when the binding member 200 is rotated to operate the operation unit 160 in a state where the coupling member 200 is coupled to the coupling hole 116a and the binding hole 142, the guide screw 150 may move linearly with respect to the operation unit 160. As a result, the plunger 120 may move with respect to the barrel 110 by the rotation operation of the operation unit 160. Such a structure makes it possible to more finely and stably adjust the arrangement of the plunger 120 relative to the barrel 110.

As described above, although described with reference to the preferred embodiment of the present invention, those skilled in the art various modifications and variations of the present invention without departing from the spirit and scope of the invention described in the claims below I can understand that you can.

110: barrel 112: nozzle
114: finger flange 120: plunger
122: binding hole 200: binding member
300: adapter 310: barrel seat
312: fixing hole 314: finger flange fixing groove
320: plunger seat

Claims (14)

In the centrifugal separator used to extract the target component from the object to be treated by centrifugation,
A barrel having a nozzle formed at one end thereof;
A plunger accommodated in the barrel so as to be linearly movable at the other end of the barrel and having a binding hole; And
A binding member provided selectively to the binding hole to constrain the movement of the plunger relative to the barrel;
Centrifugal apparatus comprising a. The method of claim 1,
The binding hole is formed in plural spaced apart along the longitudinal direction of the plunger,
The binding member is bound to any one of the plurality of binding holes in accordance with the arrangement of the plunger relative to the barrel. The method of claim 2,
A plurality of the binding holes are centrifugal apparatus, characterized in that formed spaced apart at uniform or non-uniform intervals. The method of claim 1,
A coupling hole is formed in the barrel,
The binding member is a centrifugal separator characterized in that the binding hole is bound to pass through the coupling hole. The method of claim 3,
Further comprising a support provided on the other end of the barrel,
The coupling hole is a centrifugal separator, characterized in that formed on the support. The method of claim 1,
And an adapter comprising a barrel seating portion on which the barrel is seated and a plunger seating portion on which the plunger is seated.
The adapter is provided with a fixing hole corresponding to the binding hole, the binding member is passed through the binding hole is characterized in that the centrifugal separator is fixed to the fixing hole. The method of claim 6,
Finger flanges are formed at the other end of the barrel,
And the barrel seating portion comprises a finger flange fixing groove for fixing the finger flange. The method of claim 1,
The binding member is a centrifugal separator, characterized in that coupled to the barrel rotatably around one end. The method of claim 1,
Further comprising a movable binding unit provided to selectively linearly move on the plunger,
The binding hole is a centrifugal separator, characterized in that formed in the movable binding portion. 10. The method of claim 9,
Is provided rotatably on the plunger, and further comprising an operation unit for linearly moving on the plunger according to the rotation operation,
The movable binding unit is a centrifugal separator characterized in that the linear movement by the operation unit. The method of claim 10,
The plunger is provided with a guide screw,
The operation unit is mounted on the guide screw, the centrifugal separator characterized in that the linear movement along the guide screw by the rotation operation. The method of claim 1,
The target component,
The object to be treated in the barrel is first centrifuged, and one specific component disposed on the nozzle side by the first centrifugal is discharged through the nozzle, and then the nozzle direction is reversed so that the inside of the barrel Separating the object to be treated by the second centrifugation and discharging the other specific component disposed on the nozzle side by the second centrifugation through the nozzle,
Centrifugal separator, characterized in that remaining inside the barrel. The method of claim 12,
In the first centrifugation step, the barrel is arranged such that the nozzle faces outward of the center of rotation of the barrel,
In the second centrifugation step, the barrel is a centrifugal separator, characterized in that the nozzle is disposed so as to face the inside of the rotation center of the barrel. The method of claim 12,
When the object to be treated is blood,
The one specific component separated by the first centrifugation comprises red blood cells, the other specific component isolated by the second centrifugation includes plasma,
The target component remaining in the barrel after each specific component is discharged, characterized in that it comprises a platelet (blood platelet).

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