KR101017507B1 - Mouthwash product - Google Patents

Abstract

The present invention relates to an oral cleaning product in which an oral detergent solution is mounted in a container having a predetermined space, wherein the oral detergent solution comprises a first layer made of an emulsion and a double layer of a second layer made of an aqueous agent. The first layer includes the oil-soluble drug substance dissolved in the oil-based agent, and the second layer includes the water-soluble drug substance dissolved in the water-based agent. The oral cleaning product according to the present invention can stably contain both oil-soluble and water-soluble drug active ingredients, thereby more effectively expressing its function as an oral cleaning product.

Description

Mouthwash product {Mouthwash product}

The following drawings attached to this specification are illustrative of preferred embodiments of the present invention, and together with the detailed description of the invention to serve to further understand the technical spirit of the present invention, the present invention is a matter described in such drawings It should not be construed as limited to.

1 is a cross-sectional view showing an oral cleaning product according to an embodiment of the present invention.

The present invention relates to an oral cleaning product in which a mouthwash solution is mounted in a container having a predetermined space.

The primary use of oral cleansing products is to contribute to oral hygiene by removing plaque or food debris from areas that cannot be removed by brushing. Significant diseases occurring in the teeth and surrounding tissues are caries and periodontal disease, and the main cause of this problem is plaque (or plaque). The plaque is a soft amorphous deposit formed on the surfaces of teeth and gingiva etc., the main component of which is bacteria and their metabolites. Major metabolites include organic acids produced by toxins and bacteria metabolizing sugars. These toxins cause damage to surrounding tissues adjacent to the tooth surface and cause periodontal disease, and organic acids decay tooth surfaces and cause tooth decay.

Oral cleaning products contain useful and water-soluble medicinal ingredients to prevent oral diseases such as tooth decay caused by such plaques. Since a conventional oral cleaning product consists of a single phase, in order to simultaneously contain such oil-soluble and water-soluble active ingredients, a mouthwash solution solution solubilized or emulsified using a surfactant is mounted in a container. Liquid oral clean products in such a state has a problem that the efficacy is lost or reduced by various physicochemical reactions, such as a certain period of time or the pharmacological components of the oral detergent solution is precipitated or oxidized depending on the storage temperature.

Therefore, the technical problem to be achieved by the present invention is to solve the problems of the prior art, to provide an oral cleansing product that can more effectively express the function as an oral cleansing product by containing a stable usefulness and water-soluble active ingredient at the same time.

In order to solve the above technical problem, the present invention provides an oral cleansing product in which a mouthwash solution is mounted in a container having a predetermined space, wherein the mouthwash solution is separated from the first layer and the first layer and is made of a waterborne agent. It is composed of a double layer of two layers, wherein the first layer comprises an oil-soluble drug ingredient dissolved in the oil-based agent, the second layer is an oral cleansing product characterized in that it comprises a water-soluble drug ingredient dissolved in the water-based agent To provide.

In the oral cleansing product of the present invention, as an emulsion, olive oil, rapeseed oil, soybean oil, cottonseed oil, grain oil or grain germ oil, palm oil, silicone oil, or the like may be used alone or in combination of one or more thereof. Examples thereof include soledoxoxycholine acid, triclosan, cetylpyridinium chloride, chlorhexidine gluconate, benzalkonium chloride, benzetonium chloride, oil-soluble green tea extract, oil-soluble bark extract, and the like.

In addition, in the oral cleansing product of the present invention, it is preferable to use sodium fluoride as the water-soluble active ingredient.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. Prior to this, terms or words used in the specification and claims should not be construed as having a conventional or dictionary meaning, and the inventors should properly explain the concept of terms in order to best explain their own invention. Based on the principle that can be defined, it should be interpreted as meaning and concept corresponding to the technical idea of the present invention. Therefore, the embodiments described in the specification and the drawings shown in the drawings are only the most preferred embodiment of the present invention and do not represent all of the technical idea of the present invention, various modifications that can be replaced at the time of the present application It should be understood that there may be equivalents and variations.

The term "oil-based" as used in the present specification and claims refers to liquids that are separated from each other when mixed with an aqueous base and exist as separate layers, whereas the term aqueous base is separated from each other when mixed with an oil-based base as separate layers. Means liquid present. In addition, the term oil-soluble active ingredient is a component that can be dissolved in an oily base, it means a natural or synthetic material that can promote the hygiene of the oral cavity, and the term water-soluble active ingredient is a component that can be dissolved in an aqueous base, By natural or synthetic material that can promote the hygiene of the bulbous.

1 is a cross-sectional view of an oral cleaning product according to an embodiment of the present invention. Referring to FIG. 1, the oral cleansing product 10 of the present invention is an oral cleansing product in which the oral cleanser solution 3 is mounted in a container 1 having a predetermined space, and the oral cleanser solution 3 is made of an oily agent. It consists of the double layer of the 1st layer 3a and the 2nd layer 3b made from the water-receiving agent separated from the 1st layer 3a.

The first layer 3a includes an oil-soluble active ingredient dissolved in an oil-based agent, and the oil-based agent includes olive oil, rapeseed oil, soybean oil, cottonseed oil, grain oil or grain germ oil, palm oil, silicone oil, etc. alone or in combination thereof. Can be used, but is not limited thereto. In addition, the oil-soluble medicinal ingredients include urodesoxycholine acid, triclosan, cetylpyridinium chloride, chlorhexidine gluconate, benzalkonium chloride, benzetonium chloride, oil-soluble green tea extract, oil-soluble bark extract, and the like.

In addition, the second layer 3b includes a water-soluble active ingredient dissolved in a water-based agent such as distilled water. Examples of the water-soluble active ingredient include sodium fluoride, and the like.                     

As such, each of the active ingredients is stably stored for a long time by dissolving the oil-soluble active ingredient and the water-soluble active ingredient separately in the first layer of the oil-based agent and the second layer of the water-based agent in which the respective active ingredients can stably exist. Can more effectively express the function as an oral cleaning product.

In the oral cleaning product of the present invention, the content of the emulsion is preferably 1% by weight to 80% by weight, most preferably 30% by weight, based on the total weight of the mouthwash solution. If the content of the emulsion is less than 1% by weight, it is difficult to take advantage of the stable maintenance of the active ingredient and the dual layer, and if it exceeds 80% by weight, it is difficult to realize the fresh feeling unique to the fern due to the increase of the first layer of the emulsion. In addition, the content of the oil-soluble active ingredient dissolved in the oil-based agent contains an effective amount capable of exerting the drug. The effective amount may vary depending on the type of the drug, but considering the general effective amount and solubility, the total weight of the mouthwash solution is determined. It is preferably contained from 0.001% to 5% by weight, most preferably 0.5% by weight.

In addition, in the oral cleaning product of the present invention, the second layer of the water-receiving agent may be prepared in a composition having a conventional oral cleaning agent. The amount of the water-soluble active ingredient dissolved in the water-receiving agent also contains an effective amount that can exert its efficacy.The effective amount may vary depending on the type of the active ingredient, but considering the general effective amount and solubility, it is based on the total weight of the mouthwash solution. It is preferred to contain 0.01% to 0.05% by weight, most preferably 0.02% by weight.

Hereinafter, the present invention will be described in detail with reference to Examples. However, embodiments according to the present invention can be modified in many different forms, the scope of the present invention should not be construed as limited to the embodiments described below. Embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

Comparative Examples 1 and 2

According to the ingredients and contents shown in Table 1 below, a product having a general conventional single-phase mouthwash solution was prepared.

Examples 1-6

According to the components and contents shown in Table 2 below, a product in which the double layer oral cleanser solution was mounted was manufactured.

The bilayer oral cleaning agent was prepared by separating the first layer of the oily agent and the second layer of the waterborne agent, respectively. First, the oil-soluble drug ingredient was measured and added to the emulsion, and stirred until completely dissolved. Then, the flavourant was added and stirred to be completely dispersed.

In addition, the water-soluble active ingredient was measured in purified water, which is a water-based agent, and completely dissolved by stirring, and then a pH adjuster and a flavoring agent were added and stirred. Subsequently, ethanol in which the dye was dissolved was added to the water-receiving agent, sufficiently stirred, and left standing.

The obtained emulsion composition and the receiver composition were finished in a container in a weight ratio of about 3: 7, and the preparation was completed. The mouthwash solution of the finished mouthwash product was separated into two layers. These oral cleaning products shake several times during use to allow the oily layer and the aqueous layer to be sufficiently mixed, and then subtract 10 ~ 15ml into the mouth and gargle.                     

After using the products of Comparative Examples and Examples prepared by the above-described method, clinical experiments were conducted on the effect of inhibiting plaque formation and the effect of inhibiting gingival inflammation. The experimental method is as follows.

① Screening the subject and explain the oral examination.

② Randomly divide 30 subjects into each of the Examples and Comparative Examples, train the correct method of using oral cleansers, and then perform oral examinations to determine the Qi-Hein Index modified by Turesky and the Gingival Bleeding Index (Loe-). Silness Index) is measured.

(3) Scale before the example.

④ Comparative Example After oral use of the product for 14 days, oral examination was performed. At this time, the plaque index and the gingival index were initial values.

⑤ Example and Comparative Example The product was divided into each subject and used five times a day for three months and the oral examination was performed at one month and three months to score the plaque index and the gingivitis index. At this time, the toothpaste was used as the same product and brushed three times a day.

⑥ The results of the experiments were compared with the initial values of the scores after 1 month and 3 months, and the statistical significance was tested by t-test, respectively.

Plaque Index (Prague Index)

After 3 months of use of the oral cleansing products of Comparative Examples and Examples, the plaque index was measured, and statistically significant tests were shown in Table 3.                     

Referring to Table 3, it was confirmed that there is a significant effect before and after use in the plaque formation inhibitory effect in Comparative Examples 1 and 2 and Examples 1 to 6, the composition higher than the base content of the whole oil layer Inhibition of plaque formation was better in. As shown in Examples 5 and 6, the content of the total oil-soluble base was higher in Example 5, but the higher content of silicone oil showed a better plaque formation inhibitory effect. Therefore, the use of a certain ratio of silicone oil in the total availability of the base can be evaluated as having an excellent effect of inhibiting plaque formation. In addition, when comparing the comparative examples 2 and Examples 1 to 6 it was confirmed that the reduction of plaque in all products, but the reduction effect was shown to be more effective in Examples 1 to 6 in the double layer than the single phase mouthwash. there was.                     

After 3 months, the comparison of the products of Comparative Example 1 and Examples 1 to 6 showed statistically significant reduction in plaque index (p <0.05). As a result of comparing the products of Comparative Example 2 and Examples 1 to 6, all the experimental examples except Example 4 showed a statistically significant decrease in plaque index (p <0.05).

Gingival index

The gingiva index of the products of Comparative Examples 1 and 2 and Examples 1 to 6 was measured after 3 months, and statistically significant tests were shown in Table 4 below.

Referring to Table 4, it was confirmed that Examples 1 to 6 having a bilayer structure before and after use (after 3 months) had a significant effect compared to Comparative Examples 1 and 2 (p <0.05), particularly ur Examples 4 and 6 containing sodesoxy choline acid showed better gingival index (p <0.05).

As described above, the oral cleansing product according to the present invention is composed of a double layer, so that it can stably contain an oil-soluble active ingredient and a water-soluble active ingredient at the same time. Can be expressed more effectively.

Claims (3)

In the oral cleaning product in which the oral detergent solution is mounted in a container having a predetermined space, The oral cleanser solution is composed of a bilayer of a first layer of an oily agent and a second layer of a waterborne agent separated from the first layer, and the first layer comprises an oil-soluble drug component dissolved in the oily agent. The second layer is an oral clean product, characterized in that it comprises a water-soluble active ingredient dissolved in the water-receiving agent. According to claim 1, wherein the oil agent is any one selected from the group consisting of olive oil, rapeseed oil, soybean oil, cottonseed oil, grain oil or grain germ oil, palm oil, silicone oil and mixtures thereof, and the oil-soluble active ingredient is urso An oral cleansing product comprising any one or more selected from the group consisting of desoxycholine acid, triclosan, cetylpyridinium chloride, chlorhexidine gluconate, benzalkonium chloride, benzetonium chloride, oil-soluble green tea extract, and oil-soluble bark extract. The oral clean product according to claim 1, wherein the water soluble active ingredient comprises sodium fluoride.

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