KR100944600B1 - 치환된 퀴노벤족사진 유사체 - Google Patents

치환된 퀴노벤족사진 유사체 Download PDF

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KR100944600B1
KR100944600B1 KR20057019057A KR20057019057A KR100944600B1 KR 100944600 B1 KR100944600 B1 KR 100944600B1 KR 20057019057 A KR20057019057 A KR 20057019057A KR 20057019057 A KR20057019057 A KR 20057019057A KR 100944600 B1 KR100944600 B1 KR 100944600B1
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South Korea
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alkyl
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Korean (ko)
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KR20060029210A (ko
Inventor
제프리 피. 위튼.
마이클 슈애베
아담 시디퀴-자인
테란스 모란
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사일린 파마슈티칼스, 인크
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR20057019057A 2003-04-07 2004-04-07 치환된 퀴노벤족사진 유사체 Expired - Fee Related KR100944600B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US46127103P 2003-04-07 2003-04-07
US60/461,271 2003-04-07
US46317103P 2003-04-15 2003-04-15
US60/463,171 2003-04-15
US51953503P 2003-11-12 2003-11-12
US60/519,535 2003-11-12
US53272703P 2003-12-23 2003-12-23
US60/532,727 2003-12-23

Publications (2)

Publication Number Publication Date
KR20060029210A KR20060029210A (ko) 2006-04-05
KR100944600B1 true KR100944600B1 (ko) 2010-02-25

Family

ID=33304104

Family Applications (1)

Application Number Title Priority Date Filing Date
KR20057019057A Expired - Fee Related KR100944600B1 (ko) 2003-04-07 2004-04-07 치환된 퀴노벤족사진 유사체

Country Status (11)

Country Link
US (5) US7141565B1 (https=)
EP (1) EP1610759A4 (https=)
JP (1) JP2006522827A (https=)
KR (1) KR100944600B1 (https=)
AU (1) AU2004229489B2 (https=)
BR (1) BRPI0409105A (https=)
CA (1) CA2521810A1 (https=)
MX (1) MXPA05010776A (https=)
NO (1) NO20054669L (https=)
NZ (1) NZ543006A (https=)
WO (1) WO2004091504A2 (https=)

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US7354916B2 (en) 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
US7507727B2 (en) * 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
BRPI0409105A (pt) * 2003-04-07 2006-04-25 Cylene Pharmaceuticals Inc análogos de quinobenzoxazina substituìdos
EP1673478A4 (en) * 2003-10-14 2007-08-22 Cylene Pharmaceuticals Inc COMPETITION ASSAY FOR THE IDENTIFICATION OF MODULATORS OF QUADRUPLEX NUCLEIC ACIDS
DE102004035203A1 (de) * 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone
WO2006034113A2 (en) * 2004-09-17 2006-03-30 Cylene Pharmaceuticals, Inc. Quinolone analogs as cell proliferation inhibitors
US7652134B2 (en) 2004-09-17 2010-01-26 Cylene Pharmaceuticals, Inc. Methods for converting quinolone esters into quinolone amides
US7402579B2 (en) * 2005-04-15 2008-07-22 Cylene Pharmaceuticals, Inc. Quinobenzoxazine analogs and compositions
US7610985B2 (en) * 2005-05-18 2009-11-03 Kanzaki Kokyukoki Mfg. Co., Ltd. HST unit
DE102006005861A1 (de) 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
WO2007137000A2 (en) * 2006-05-16 2007-11-29 The Arizona Board Of Regents On Behalf Of The University Of Arizona Combination cancer chemotherapy
AU2007256698A1 (en) * 2006-06-03 2007-12-13 Cylene Pharmaceuticals, Inc. Drug administration methods
US8410070B2 (en) * 2008-09-12 2013-04-02 University Of Louisville Research Foundation, Inc. Compositions and methods for treating cancer, inhibiting proliferation, and inducing cell death
TW201120037A (en) 2009-10-26 2011-06-16 Sunesis Pharmaceuticals Inc Compounds and methods for treatment of cancer
US9730609B2 (en) * 2011-12-15 2017-08-15 Siemens Healthcare Gmbh Method and system for aortic valve calcification evaluation
JP6249436B2 (ja) * 2012-08-31 2017-12-20 国立大学法人東京農工大学 四重らせんｄｎａ検出プローブ及びそれを用いた四重らせん構造の検出方法
TR201809990T4 (en) 2014-05-09 2018-08-27 Pimera Inc NEW COMPOSITIONS, USES AND METHODS FOR THEIR MAKING.
US9758518B2 (en) 2015-03-04 2017-09-12 Pimera, Inc. Compositions, uses and methods for making them
EP3601286A4 (en) 2017-03-28 2020-09-23 Pimera, Inc. NEW CRYSTALLINE FORMS OF A POL1 INHIBITOR
US11071727B2 (en) 2018-01-26 2021-07-27 Northwestern University Therapeutic targeting of proteolytic cleavage of the mixed lineage leukemia gene product (MLL1) by taspase1 using kinase inhibitors
CN114716373B (zh) * 2022-04-14 2023-01-10 内蒙古源宏精细化工有限公司 一种加替沙星环合酯的制备方法
CN116023263A (zh) * 2022-11-17 2023-04-28 苏州汉德创宏生化科技有限公司 一种中间体3-(3,5-二氯苯基)-3-氧代丙酸乙酯的合成方法

Citations (3)

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EP0162333A1 (en) * 1984-04-26 1985-11-27 Abbott Laboratories Quino-benzothiazine antibacterial compounds
US4977263A (en) * 1986-01-15 1990-12-11 Bayer Aktiengesellschaft Process for preparing 1,8-bridged 4-quinolone-3-carboxylic acid antibacterials
US5318965A (en) * 1990-08-24 1994-06-07 Abbott Laboratories Quinobenzoxazine, antineoplastic agents

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US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4533663A (en) 1984-04-26 1985-08-06 Abbott Laboratories Quino-benzothiazine antibacterial compounds
US4528285A (en) * 1984-04-26 1985-07-09 Abbott Laboratories Methylenedioxy quino-benzothiazine derivatives
US4607032A (en) * 1984-04-26 1986-08-19 Abbott Laboratories Quino-benoxazine antibacterial compounds
EP0160284B1 (en) * 1984-04-26 1990-10-24 Abbott Laboratories Quino-benoxazine antibacterial compounds
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
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US5225418A (en) 1991-12-17 1993-07-06 Du Pont Merck Pharmaceutical Company 5H-(1,2)benzisothiazolo[2,3-a]quinoline-5-ones and analogs as antiinflammatory agents
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ATE415969T1 (de) * 1999-05-07 2008-12-15 Wockhardt Ltd (s)-benzochinolizincarbonsäuren und ihre verwendung als antibakterielle mittel
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BRPI0409105A (pt) 2003-04-07 2006-04-25 Cylene Pharmaceuticals Inc análogos de quinobenzoxazina substituìdos
WO2004091627A2 (en) 2003-04-07 2004-10-28 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs
US7354916B2 (en) * 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
CN100390771C (zh) * 2003-05-07 2008-05-28 皇家飞利浦电子股份有限公司 用于发送数据的处理系统和方法
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EP0162333A1 (en) * 1984-04-26 1985-11-27 Abbott Laboratories Quino-benzothiazine antibacterial compounds
US4977263A (en) * 1986-01-15 1990-12-11 Bayer Aktiengesellschaft Process for preparing 1,8-bridged 4-quinolone-3-carboxylic acid antibacterials
US5318965A (en) * 1990-08-24 1994-06-07 Abbott Laboratories Quinobenzoxazine, antineoplastic agents

Also Published As

Publication number Publication date
US20080261963A1 (en) 2008-10-23
US20120122804A1 (en) 2012-05-17
WO2004091504A3 (en) 2006-01-05
US20070043039A1 (en) 2007-02-22
US7326702B2 (en) 2008-02-05
EP1610759A2 (en) 2006-01-04
NO20054669L (no) 2005-11-14
US7141565B1 (en) 2006-11-28
US7381720B2 (en) 2008-06-03
WO2004091504A2 (en) 2004-10-28
CA2521810A1 (en) 2004-10-28
AU2004229489B2 (en) 2010-03-04
BRPI0409105A (pt) 2006-04-25
AU2004229489A1 (en) 2004-10-28
NZ543006A (en) 2009-03-31
US20060229303A1 (en) 2006-10-12
EP1610759A4 (en) 2007-04-25
KR20060029210A (ko) 2006-04-05
US7612063B2 (en) 2009-11-03
MXPA05010776A (es) 2006-05-25
NO20054669D0 (no) 2005-10-11
JP2006522827A (ja) 2006-10-05

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