KR100940912B1 - Cosmetics for improvement xeroderma containing ostrich oil - Google Patents

Abstract

PURPOSE: A cosmetic composition for relieving xeroderma containing Struthio camelus oil is provided to enhance skin moisturization and control keratin layer formation. CONSTITUTION: A cosmetic composition for relieving xeroderma contains 1.0-10.0 weight% of Struthio camelus oil, 1.0-10.0 weight% of Echinacea purpurea extract, 1.0-5.0 weight% of Leptospermum scoparium, and 0.1-10.0 weight% of Podocarpus totara extract. The extract is isolated using distilled water, ethanol, methanol, propanol, butanol, acetone, ethylacetate, hexane, hydrous butyleneglycol, hydrous propyleneglycol or hydrous glycerin. The cosmetic composition is used in the form of basic cosmetic product, cleansing product, makeup cosmetic product, or cosmetic product for baby.

Description

Cosmetic for improving dry skin containing ostrich oil {Cosmetics for improvement xeroderma containing ostrich oil}

The present invention relates to a cosmetic for improving skin dryness containing ostrich oil.

Atopic dermatitis is a type of eczema of one of several species and is a representative disease of eczema, also called contact dermatitis. The recent social attention of this atopic dermatitis has been increasing, which is increasing the number of children who can be diagnosed with atopic dermatitis, the recurrence of the disease is repeated, and even the social life of people involved in the disease because it does not heal as adults This is a threatening situation. It is estimated that 10 to 20% of the world's population suffers from this dermatitis.Atopic dermatitis has been reported in recent decades due to the increase of substances that cause airborne allergens due to environmental pollution and the increase of conditions that form dry skin. The prevalence of sexual dermatitis continues to rise. However, as the etymology of the word atopy means 'weird' or 'inappropriate', it is true that the cause of the onset or the obvious solution is not yet known.

Clinically, atopic dermatitis has a relatively characteristic skin lesion and distribution according to the patient's age, and most of the symptoms occur at 2 to 6 months of age. This is divided into three periods, such as infancy, childhood, and puberty / adult. In the first two to three months of age when atopic dermatitis begins, the symptoms of atopic dermatitis tend to develop red spots around the face, especially the cheeks, and gradually spread toward the ears or the neck as it becomes severe. This period tends to be accompanied by a lot of oozes, sometimes with diaper rash or severe sweating on the neck. In the early years of 3-7 years of age, unlike infancy, a lot of rash does not occur, but only the face appears white. In general, during this time, the child's skin is very rough, dry, and severely itchy than other children of the same age. This is especially true for folds such as around the neck, back of the elbow or knee. There are some differences between the ages of 12 and 12. Most children have fewer symptoms in infancy and early childhood, but some have thickened skin and a pigmented condition. After puberty, atopic dermatitis usually improves with age, but symptoms may persist until adulthood.

As a result of a decrease in water retention ability, which is one of the characteristics of atopic dermatitis patients, is reported to be due to the decrease in the amount of ceramide, a lipid that retains the moisturizing function and barrier function of the stratum corneum, dry skin, an important phenomenon of atopic dermatitis, It was a chance to be considered newly. When dry skin is formed, the barrier function on the surface of the skin is lost, and it is easy to invade the skin by irritants or antigens from the outside, and the skin is rejected against such invasion. Rejection of keratinocytes, which make up the majority of stratum corneum components, activates cells such as Langerhans and melanocytes by keratinocytes, which are produced by the cytokines produced by these cells. It is known to appear as an inflammatory phenomenon. Said cytokines stimulate and collect inflammatory cells, and in particular, stimulate constituent cells of the skin to cause inflammatory reactions around the upper layers of the skin and to form eczema, commonly referred to as non-allergic skin diseases.

Several compositions have been proposed as a method for treating skin dryness and itching, such as atopic dermatitis, but all of these compositions are pharmaceutical compositions, most of which include steroid preparations and antibiotics as active ingredients. When applied, it may cause serious side effects such as capillary bloating and dilated and / or thickening of the stratum corneum, and recently, a composition mainly composed of gamma-linolenic acid, which is widely used to alleviate atopic dermatitis, is easily oxidized and thus stable. In addition to this inferiority, the skin irritation is relatively strong, which makes it difficult to use for sensitive skin.

Therefore, the present inventors have studied to solve the above problems, ostrich oil with excellent moisturizing effect, wetting effect, high penetration effect and skin regeneration ability, to prevent infection, promote healing and enhance the immune function of the human body Echinacea purpurea extract, australian plum extract with strong antibacterial, anti-inflammatory and skin protection effect and grape calf totara extract with antioxidant, antibacterial and skin astringent effect in certain ratios improves moisturizing effect and prevents drying The present invention has been completed by confirming that the capability is excellently increased.

Accordingly, an object of the present invention is to provide a cosmetic for improving skin dryness containing ostrich oil, echinacea purpurea extract, australian plum extract and grape calpus totara extract as an active ingredient.

The present invention is characterized by a cosmetic for improving skin dryness containing ostrich oil, echinacea purpurea extract, australian plum extract and grape calpus totara extract as an active ingredient.

The present invention will be described in more detail as follows.

The present invention is an ostrich ( Struthio camelus ) oil, Echinacea purpurea purpurea ) Extract, Australian Plum (Tree, Leptospermum) scoparium extract and Podocarpus totara ) extracts are used in a specific ratio to enhance skin moisturizing function and control the formation of the stratum corneum to restore the skin barrier function and to treat and improve skin dryness such as atopic dermatitis.

Ostrich (ostrich, scientific name:Struthio camelus) Stores fat in the belly. Fats contain a lot of nutrients, but if you lack nutrients, you live from there. The white color is white when there is sufficient nutritional balance, but the fat color is yellow in unbalanced nutrition.

Although ostrich oil is an animal fat or oil, the unsaturated fatty acid content is 76%, and the essential fatty acid (also known as vitamin F) is 38.5%, which has a very high proportion, which is good for skin. It does not clog pores. Ostrich oil also contains significant amounts of natural estrogen.

The method of manufacturing ostrich oil is as follows: 1) remove the non-edible portion of the sanitized slaughtered ostrich, and then, 2) compress it with a press to collect oil, and 3) separate water and ostrich oil by natural filtration. 4) Go to the filter and evaporate and sterilize residual water at 100 ℃ after filtration, 5) Move the above oil to the filling machine, 6) Fill the cap with the solution in the antibacterial sterilized bottle, 7) Finished capped product Sterilize at 80 ℃ for 2 hours, then carry out strict product inspection and pack the product as it passes. The ostrich oil thus produced is a white liquid, inherent in its color and aroma and free of odors.

Echinacea purpurea is also native to eastern North America, native to the eastern, southeastern and midwestern regions of the United States, commonly called Purple Coneflower. The height grows about 60 to 120 cm, the stem is straight and covered with soft hairs. Leaves are alternate, petioles get shorter as they go up, long oval shape with flat edges, pointed leaves and narrow under leaves, leading to petioles. It is a herb used by Native Americans as a natural antibiotic and therapeutic agent for various infections or when bitten by poisonous insects or insects. It enhances the body's immune function to prevent the invasion of viruses, fungi and bacteria. It is known to prevent infections and allergies and to improve symptoms.

This echinacea purpurea extract is used as one of the active ingredients of the present invention, and is commonly used, and dried echinacea purpurea is used as an extraction solvent, distilled water, ethanol, methanol, propanol, butanol, acetone, ethyl 5-10 times the volume of one or more solvents selected from the group consisting of acetate, hexane, butylene glycol, hydrous propylene glycol, and hydrous glycerin, is added to a volume of 5 to 10 times to provide a cooling condenser to prevent the solvent from evaporating. It is possible to use a method of extracting the active ingredient by soaking for 5 days. This means that the extract Echinacea purpurea extracted through the filtration and sterilization process.

In addition, Australian plum (tea tree, Leptospermum scoparium ) is a shrub commonly found in New Zealand, especially on the east coast of North and South islands, and Australia. The English name tea tree is also called Manuka. It is a 2.5-meter-long evergreen tree that blooms white flowers all year round, and the tree is hard and can be used as a handle for extension.It is made from smoked dishes using unique sawdust, and is also popular as a winter firewood. Manuka is the name of the Scoparium species in the Raptospermum, called the Maori, a New Zealand native, called the Red Tea Tree or the New Zealand Tea Tree. Manuka is not as widely known as tea tree, but it is an oil of recent interest as a powerful antimicrobial effect is known. Manuka grows throughout New Zealand and southern Australia, but the strong antibacterial essential oils and manuka honey are produced in the East Cape, an island in northern New Zealand. The ingredient that supports Manuka's antimicrobial activity is Triketone, which accounts for more than 25% of the total, which is particularly resistant to Gram-positive bacteria, and is also effective against Gram-negative bacteria, fungi and yeast. According to the experimental results, Manuka shows 20 times more activity than tea tree against Gram-positive bacteria such as staphylococcus, epidermal staphylococcus and streptococci. Manuka oil stabilizes the skin while at the same time strengthening the mind, activating the epidermal layer of the skin and enhancing regeneration. Manuka oil is not very sensitive, so it is good if you are allergic to sensitive skin, especially itchy skin, acne, poor healing, inflammatory skin, and especially tea tree. The Australian plum extract is used as one of the active ingredients of the present invention, and is commonly used. After drying the Australian plum, it is dried by 1 to 15 times the volume of water, a lower alcohol having 1 to 4 carbon atoms, or Mixtures of these lower alcohols with water, one or more solvents selected from the group consisting of ethyl acetate, water, glycerin, ethylene glycol, propylene glycol, butylene glycol, and then use a cooling condenser to prevent the solvent from evaporating After extracting by heating for 2 to 12 hours at 30 ~ 100 ℃ with an extractor equipped, it means an extract obtained by concentrating the extraction solvent in a vacuum condenser.

In addition, Podocarpus totara is an evergreen conifer tree and shrub of Nado Podocarpaceae and can be used as wood. Grow up to 30 meters high. Its life span is between 800 and 1800 years. The Maori, New Zealand's indigenous people, used Totara a variety of sculptures, buildings, furniture, and fences, while the bark and stem contained antibacterial totarol and grape capric acid, which had a convergent and antipyretic effect. podocarpric acid) is extracted. The grape calpus totara extract is used as one of the active ingredients of the present invention, and is commonly used. As the extract solvent, grape calpus totara, distilled water, ethanol, methanol, propanol, butanol, acetone, ethyl acetate, hexane, 5 to 10 times the volume of one or more solvents selected from the group consisting of hydrous butylene glycol, hydrous propylene glycol, and hydrous glycerin is added, and a cooling condenser is installed for 1 to 5 days at room temperature while preventing the solvent from evaporating. The method of extracting the active ingredient can be used. This means that the extract is prepared by filtration and sterilization process grape calyptus totara.

In the present invention, it is preferable to use 1.0 to 10.0% by weight of ostrich oil, and if the content thereof is less than 1.0% by weight, the effect is insignificant. There is a problem.

In addition, the preferred content of the Echinacea purpurea extract in the present invention is 1.0 ~ 10.0% by weight, the problem is that the effect does not appear if less than 1.0% by weight, the effect does not increase any more than 10.0% by weight There is a problem and is undesirable.

In addition, the preferred content of the Australian plum extract in the present invention is 0.1 to 5.0% by weight, it is a problem that the effect does not appear if less than 0.1% by weight, there is an oily problem when it exceeds 5.0% by weight is not preferable.

In addition, in the present invention, it is preferable to use the extract of grape calpus totara, 0.1 ~ 10.0% by weight, when less than 0.1% by weight has a slight problem, the effect does not increase even when exceeding 10.0% by weight. There is a problem.

Therefore, the present invention using the above four ingredients as an active ingredient when applied to cosmetics cosmetic products (cosmetics, lotions, creams, essences), face wash cosmetics (cleansing foam, cleansing water, cleansing gel, pack), body products Cosmetics (Body Lotion, Body Oil, Body Gel), Color Cosmetics Cosmetics (Foundation, Lipstick, Mascara, Makeup Base), Hair Products Cosmetics (Shampoo, Rinse, Hair Conditioner, Hair Gel), Baby Products Cosmetics (Baby Lotion, Baby) Oil, baby cream) and the like, and more preferably, the above-mentioned effective ingredient is suitably blended with respect to the entire cosmetic composition such as skin lotion (skin lotion), nutrition lotion, nutrition cream, massage cream and essence. That is, it is a feature of the present invention to use ostrich oil, echinacea purpurea extract, australian plum extract and grape calpus totara extract as active ingredients in addition to the components of cosmetics generally used.

As described above, the cosmetics according to the present invention contains ostrich oil, echinacea apurfuria extract, australian plum extract, and grape calpus totara extract as an active ingredient, which is excellent in moisturizing effect and skin drying effect. It is expected to be very useful for the treatment and improvement of dry skin such as atopic dermatitis.

Hereinafter, the present invention will be described in more detail based on the following examples, but the present invention is not limited thereto.

Example  1 to 6: preparation of nourishing cream

First, the oil phase and the water phase were prepared according to a 75 ° C. blender, and then the oil phase was slowly added to the water phase, emulsified at 3000 rpm for 10 minutes with a homo mixer, and then cooled to room temperature to prepare the cosmetic compositions of Examples 1-6.

Nutritional Cream-Composition and Contents (wt%) number Raw material name Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 One Monostearic acid polyoxyethylene sorbitan 1.2 1.2 1.2 1.2 1.2 1.2 2 antiseptic 0.2 0.2 0.2 0.2 0.2 0.2 3 Cetanol 0.4 0.4 0.4 0.4 0.4 0.4 4 Sorbitan monosulfate 0.3 0.3 0.3 0.3 0.3 0.3 5 Cetostearyl alcohol 0.8 0.8 0.8 0.8 0.8 0.8 6 Stearic acid 0.5 0.5 0.5 0.5 0.5 0.5 7 Dimethicone 0.5 0.5 0.5 0.5 0.5 0.5 8 Cetyloctanoate 4.0 4.0 4.0 4.0 4.0 4.0 9 Squalane 3.0 3.0 3.0 3.0 3.0 3.0 10 Concentrated glycerin 5.0 5.0 5.0 5.0 5.0 5.0 11 1,2-butylin glycol 4.0 4.0 4.0 4.0 4.0 4.0 12 Carboxy Vinyl Polymer 0.1 0.1 0.1 0.1 0.1 0.1 13 Triethanolamine 0.1 0.1 0.1 0.1 0.1 0.1 14 Ostrich oil 1.0 3.0 5.0 7.0 9.0 10.0 15 Echinacea Purpurea Extract 4.0 3.0 8.0 2.0 6.0 10.0 16 Australian Plum Extract 0.5 1.0 1.5 2.0 3.0 4.0 17 Staphylococcus Totara Extract 8.0 6.0 5.0 3.0 2.0 1.0 18 Purified water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount   system 100 100 100 100 100 100

Comparative example  1 to 6

Next, the nutritional cream was prepared by performing the composition of Table 2 in the same manner as in Example.

Nutritional Cream-Composition and Contents (wt%) number Raw material name Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 One Monostearic acid polyoxyethylene sorbitan 1.2 1.2 1.2 1.2 1.2 1.2 2 antiseptic 0.2 0.2 0.2 0.2 0.2 0.2 3 Cetanol 0.4 0.4 0.4 0.4 0.4 0.4 4 Sorbitan monosulfate 0.3 0.3 0.3 0.3 0.3 0.3 5 Cetostearyl alcohol 0.8 0.8 0.8 0.8 0.8 0.8 6 Stearic acid 0.5 0.5 0.5 0.5 0.5 0.5 7 Dimethicone 0.5 0.5 0.5 0.5 0.5 0.5 8 Cetyloctanoate 4.0 4.0 4.0 4.0 4.0 4.0 9 Squalane 3.0 3.0 3.0 3.0 3.0 3.0 10 Concentrated glycerin 5.0 5.0 5.0 5.0 5.0 5.0 11 1,2-butylin glycol 4.0 4.0 4.0 4.0 4.0 4.0 12 Carboxy Vinyl Polymer 0.1 0.1 0.1 0.1 0.1 0.1 13 Triethanolamine 0.1 0.1 0.1 0.1 0.1 0.1 14 Ostrich oil 1.0 0.5 5.0 12.0 - - 15 Echinacea Purpurea Extract 3.0 8.0 0.5 - 12.0 3.0 16 Australian Plum Extract 0.01 6.0 - - - 6.0 17 Staphylococcus Totara Extract - - 12.0 3.0 5.0 0.01 18 Purified water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount   system 100 100 100 100 100 100

Test Example  1: moisture Ability  Measure

In order to confirm the water retention of the composition according to the present invention, the cosmetic emulsion compositions of Examples 1 to 6 and Comparative Examples 1 to 6 were applied to the skin, and the moisture retention was evaluated.

Twenty adult male and female subjects aged 20 to 35 years were measured. The test method is as follows.

The skin conductivity of the test subject was measured using the moisture retention measuring device (corneometer CM 820, Courage + Khazaka electronic GMBH, Germany) under constant temperature and humidity conditions (24 ℃, 40% humidity) before starting the application. Measured as the basic value, and optionally selected nine sites, after applying the cosmetics of the uncoated areas, Comparative Examples 1 to 6, Examples 1 to 6 and measuring the change in skin conductivity after 2,4,8 hours The skin moisturizing effect of the sample was evaluated, and the moisture content changed from the initial value was calculated as in Equation 1 below, and the results are shown in Table 3 below.

M _{t = i} : Moisture content measured at t = i hours

M _{t = 0} : The amount of water measured immediately before the start of the test at the material-free area (t = 0)

sample After 2 hours After 4 hours After 8 hours Example 1 84 71 54 Example 2 86 66 51 Example 3 93 79 65 Example 4 87 72 62 Example 5 90 76 63 Example 6 89 68 59 Comparative Example 1 40 23 15 Comparative Example 2 42 22 19 Comparative Example 3 56 26 18 Comparative Example 4 47 25 16 Comparative Example 5 49 29 20 Comparative Example 6 58 21 19

As shown in Table 3, the case of the mixed composition of Examples 1 to 6 was excellent in water retention capacity.

Test Example  2: Determination of Dry Skin Amelioration Effect of Atopic Dermatitis

For the cosmetics prepared according to the examples and comparative examples of Table 3, 20 test subjects with atopic dermatitis were measured to improve skin dryness and recovery of damaged skin barrier. The test method is as follows.

The test subjects were divided into two arbitrary groups, and the cosmetics of Examples 1 to 6 and Comparative Examples 1 to 6 were applied to each of the groups, and applied to the dry area (limb or face) twice a day for 1 month. The skin conductivity was measured at the test site before the start of the test and after 4 weeks of application, and 5 sites were selected before and after application to measure the change in skin conductivity, and the effect of improving the dry skin of the sample was evaluated and the results are shown in Table 4 below.

Ma: Moisture content measured at the application site after 4 weeks of material application

Mn: Moisture content measured at the uncoated area after 4 weeks of material application

Applicator Skin dryness improvement effect (%) Comparative Example 1 25.1 Comparative Example 2 23.0 Comparative Example 3 22.8 Comparative Example 4 26.5 Comparative Example 5 25.9 Comparative Example 6 27.1 Example 1 52.5 Example 2 57.8 Example 3 56.4 Example 4 58.0 Example 5 53.1 Example 6 60.3

As shown in Table 4, the cosmetics of Examples 1 to 6 was found to be excellent in the effect of improving the dry skin in dry skin of dry dermatitis of atopic dermatitis.

Test Example  3: Confirm the effect of improving atopic healing

When applying the skin to the nourishing cream of Example 3 and Comparative Example 1, the following experiment was carried out to confirm the effect of improving atopic healing.

Atopic dermatitis 5 to 30 years old, atopic dermatitis more than two years of patients with atopic dermatitis was investigated the effect of atopic dermatitis. To the same person, the nourishing cream of Example 3 was applied to the left hand and the nourishing cream of Comparative Example 1 to the right hand every evening, and then applied to the skin once a day for 60 days, and then the degree of improvement of atopic condition was confirmed to confirm the improvement of atopic condition. Was measured.

division Atopy improvement (persons) (%) Example 3 very good 10 33.3 good 15 50.0 is average 5 16.7 so so - - Comparative Example 1 very good One 3.3 good 6 20.0 is average 9 30.0 so so 14 46.7

As shown in Table 5, it was found that the cosmetic composition of Example 3 is superior to the skin healing improvement effect than Comparative Example 1.

Claims (3)

1.0 to 10.0 wt% of ostrich oil, 1.0 to 10.0 wt% of Echinacea purpurea extract, Leptospermum scoparium ) 0.1-5.0 wt% and Podocarpus totara ) skin dryness improvement cosmetics, characterized in that it contains 0.1 to 10.0% by weight of the extract. The cosmetic according to claim 1, wherein the skin dryness is atopy. The cosmetic according to claim 1, wherein the cosmetic has a formulation selected from basic cosmetics, face wash cosmetics, body cosmetics, color cosmetics and baby cosmetics.