KR100929703B1 - 코팅된 항산화제 입자, 이를 포함하는 조성물 및 그 제조방법 - Google Patents
코팅된 항산화제 입자, 이를 포함하는 조성물 및 그 제조방법 Download PDFInfo
- Publication number
- KR100929703B1 KR100929703B1 KR1020070078692A KR20070078692A KR100929703B1 KR 100929703 B1 KR100929703 B1 KR 100929703B1 KR 1020070078692 A KR1020070078692 A KR 1020070078692A KR 20070078692 A KR20070078692 A KR 20070078692A KR 100929703 B1 KR100929703 B1 KR 100929703B1
- Authority
- KR
- South Korea
- Prior art keywords
- antioxidant
- particles
- lipoic acid
- alpha lipoic
- polymer
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
Abstract
Description
Claims (18)
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- 80 내지 95중량%의 항산화제 코어 입자 및 5 내지 20중량%의 알파리포산계 화합물 입자를 1000rpm이상으로 고속 교반하여 혼합 입자를 제조하는 단계; 및상기 혼합 입자를 62℃ 이상의 온도에서 30분 이상 방치하여 알파리포산계 화합물을 중합시켜 제 1 중합체 코팅층이 형성된 1차 입자를 제조하는 단계를 포함하는 코팅된 항산화제 입자의 제조 방법.
- 제 16 항에 있어서, 상기 1차 입자를 불용성 용매에 분산시킨 다음, 상기 용매에 용해될 수 있는 중합체를 투입하고 교반한 다음, 상기 용매를 희발시켜 제 2 중합체 코팅층이 형성된 2차 입자를 제조하는 단계를 추가적으로 포함하는 코팅된 항산화제 입자의 제조 방법.
- 삭제
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020070078692A KR100929703B1 (ko) | 2007-08-06 | 2007-08-06 | 코팅된 항산화제 입자, 이를 포함하는 조성물 및 그 제조방법 |
US12/671,211 US20100255109A1 (en) | 2007-08-06 | 2008-08-04 | Stabilized antioxidant particles, composition comprising the same and method for preparing the same |
PCT/KR2008/004508 WO2009020317A2 (en) | 2007-08-06 | 2008-08-04 | Stabilized antioxidant particles, composition comprising the same and method for preparing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020070078692A KR100929703B1 (ko) | 2007-08-06 | 2007-08-06 | 코팅된 항산화제 입자, 이를 포함하는 조성물 및 그 제조방법 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020090005402A Division KR100907660B1 (ko) | 2009-01-22 | 2009-01-22 | 코팅된 항산화제 입자, 이를 포함하는 조성물 및 그 제조 방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20090014616A KR20090014616A (ko) | 2009-02-11 |
KR100929703B1 true KR100929703B1 (ko) | 2009-12-03 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020070078692A KR100929703B1 (ko) | 2007-08-06 | 2007-08-06 | 코팅된 항산화제 입자, 이를 포함하는 조성물 및 그 제조방법 |
Country Status (1)
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KR (1) | KR100929703B1 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20190057504A (ko) | 2017-11-20 | 2019-05-29 | (주)아모레퍼시픽 | 안정성이 향상된 항산화 조성물 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20050092626A (ko) * | 2004-03-16 | 2005-09-22 | 주식회사 디피아이 솔루션스 | 수상에서 비타민 c 및 그 유도체를 안정화시키기 위한조성물 및 이를 이용한 비타민 c 및 그 유도체의 안정화방법 |
JP2006045100A (ja) | 2004-08-03 | 2006-02-16 | Nisshin Pharma Inc | α−リポ酸含有カプセル剤 |
KR20060028916A (ko) * | 2004-09-30 | 2006-04-04 | 주식회사 디피아이 솔루션스 | 수-안정화된 egcg 캡슐 조성물 및 이의 제조방법 |
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2007
- 2007-08-06 KR KR1020070078692A patent/KR100929703B1/ko active IP Right Grant
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20050092626A (ko) * | 2004-03-16 | 2005-09-22 | 주식회사 디피아이 솔루션스 | 수상에서 비타민 c 및 그 유도체를 안정화시키기 위한조성물 및 이를 이용한 비타민 c 및 그 유도체의 안정화방법 |
JP2006045100A (ja) | 2004-08-03 | 2006-02-16 | Nisshin Pharma Inc | α−リポ酸含有カプセル剤 |
KR20060028916A (ko) * | 2004-09-30 | 2006-04-04 | 주식회사 디피아이 솔루션스 | 수-안정화된 egcg 캡슐 조성물 및 이의 제조방법 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20190057504A (ko) | 2017-11-20 | 2019-05-29 | (주)아모레퍼시픽 | 안정성이 향상된 항산화 조성물 |
KR20240032795A (ko) | 2017-11-20 | 2024-03-12 | (주)아모레퍼시픽 | 안정성이 향상된 항산화 조성물 |
Also Published As
Publication number | Publication date |
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KR20090014616A (ko) | 2009-02-11 |
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