KR100866974B1 - 유청 단백질 가수분해물을 유효성분으로 포함하는 항암용식품조성물 - Google Patents
유청 단백질 가수분해물을 유효성분으로 포함하는 항암용식품조성물Info
- Publication number
- KR100866974B1 KR100866974B1 KR1020070022265A KR20070022265A KR100866974B1 KR 100866974 B1 KR100866974 B1 KR 100866974B1 KR 1020070022265 A KR1020070022265 A KR 1020070022265A KR 20070022265 A KR20070022265 A KR 20070022265A KR 100866974 B1 KR100866974 B1 KR 100866974B1
- Authority
- KR
- South Korea
- Prior art keywords
- whey protein
- food composition
- whey
- ingredient
- alcalase
- Prior art date
Links
- 108010046377 Whey Proteins Proteins 0.000 title claims abstract description 52
- 235000021119 whey protein Nutrition 0.000 title claims abstract description 49
- 102000007544 Whey Proteins Human genes 0.000 title claims abstract description 48
- 235000013305 food Nutrition 0.000 title claims abstract description 21
- 239000000203 mixture Substances 0.000 title claims abstract description 9
- 239000003531 protein hydrolysate Substances 0.000 title abstract description 33
- 230000001093 anti-cancer Effects 0.000 title abstract description 12
- 239000004615 ingredient Substances 0.000 title description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims abstract description 11
- 102000005158 Subtilisins Human genes 0.000 claims abstract description 11
- 108010056079 Subtilisins Proteins 0.000 claims abstract description 11
- 201000005202 lung cancer Diseases 0.000 claims abstract description 9
- 208000020816 lung neoplasm Diseases 0.000 claims abstract description 9
- 206010006187 Breast cancer Diseases 0.000 claims abstract description 7
- 208000026310 Breast neoplasm Diseases 0.000 claims abstract description 7
- 239000012141 concentrate Substances 0.000 claims description 3
- 102000004157 Hydrolases Human genes 0.000 abstract description 11
- 108090000604 Hydrolases Proteins 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 10
- 239000005862 Whey Substances 0.000 abstract description 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 15
- 210000004881 tumor cell Anatomy 0.000 description 13
- 235000013365 dairy product Nutrition 0.000 description 8
- 230000009422 growth inhibiting effect Effects 0.000 description 7
- 238000006460 hydrolysis reaction Methods 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 5
- 230000007062 hydrolysis Effects 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 230000004663 cell proliferation Effects 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- 230000009036 growth inhibition Effects 0.000 description 4
- 108091005804 Peptidases Proteins 0.000 description 3
- 102000035195 Peptidases Human genes 0.000 description 3
- 230000000259 anti-tumor effect Effects 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 230000001766 physiological effect Effects 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000035484 reaction time Effects 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 2
- 208000009956 adenocarcinoma Diseases 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 239000000416 hydrocolloid Substances 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- 201000005296 lung carcinoma Diseases 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 108010009355 microbial metalloproteinases Proteins 0.000 description 2
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 2
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 230000004565 tumor cell growth Effects 0.000 description 2
- 241001239379 Calophysus macropterus Species 0.000 description 1
- 108010065152 Coagulase Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000008192 Lactoglobulins Human genes 0.000 description 1
- 108010060630 Lactoglobulins Proteins 0.000 description 1
- 238000000134 MTT assay Methods 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007071 enzymatic hydrolysis Effects 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000004136 fatty acid synthesis Effects 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 201000006585 gastric adenocarcinoma Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000008975 immunomodulatory function Effects 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000005265 lung cell Anatomy 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000007758 minimum essential medium Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/308—Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/54—Proteins
- A23V2250/542—Animal Protein
- A23V2250/5424—Dairy protein
- A23V2250/54252—Whey protein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
Claims (2)
- 유청 단백질 농축물(WPC)에 알칼라제를 pH 6.5, 45℃에서 5~6시간 반응시켜 얻은 유청 단백질 농축물의 가수분해물을 유효성분으로 함유하는 유방암 또는 폐암 예방용 식품 조성물.
- 삭제
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020070022265A KR100866974B1 (ko) | 2007-03-07 | 2007-03-07 | 유청 단백질 가수분해물을 유효성분으로 포함하는 항암용식품조성물 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020070022265A KR100866974B1 (ko) | 2007-03-07 | 2007-03-07 | 유청 단백질 가수분해물을 유효성분으로 포함하는 항암용식품조성물 |
Publications (2)
Publication Number | Publication Date |
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KR20080082041A KR20080082041A (ko) | 2008-09-11 |
KR100866974B1 true KR100866974B1 (ko) | 2008-11-05 |
Family
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Family Applications (1)
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KR1020070022265A KR100866974B1 (ko) | 2007-03-07 | 2007-03-07 | 유청 단백질 가수분해물을 유효성분으로 포함하는 항암용식품조성물 |
Country Status (1)
Country | Link |
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KR (1) | KR100866974B1 (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021060927A1 (ko) * | 2019-09-25 | 2021-04-01 | 매일유업 주식회사 | 유청단백 가수분해물을 유효성분으로 함유하는 근감소증의 개선, 예방 또는 치료용 조성물 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02408A (ja) * | 1986-01-07 | 1990-01-05 | Warner Lambert Co | 可食無溶媒封入組成物 |
JPH05176713A (ja) * | 1990-09-20 | 1993-07-20 | Morinaga Milk Ind Co Ltd | 脂質代謝改善に有効な機能性食品 |
US6863918B2 (en) | 1999-12-13 | 2005-03-08 | N.V. Nutricia | Infant formula with improved protein content |
JP2005139084A (ja) | 2003-11-04 | 2005-06-02 | Morinaga Milk Ind Co Ltd | システインプロテアーゼ阻害剤 |
KR20070034212A (ko) * | 2005-09-23 | 2007-03-28 | 윤영호 | 유청단백질 가수분해물을 유효성분으로 함유한 면역강화 또는 항산화용 건강기능식품 |
-
2007
- 2007-03-07 KR KR1020070022265A patent/KR100866974B1/ko active IP Right Grant
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02408A (ja) * | 1986-01-07 | 1990-01-05 | Warner Lambert Co | 可食無溶媒封入組成物 |
JPH05176713A (ja) * | 1990-09-20 | 1993-07-20 | Morinaga Milk Ind Co Ltd | 脂質代謝改善に有効な機能性食品 |
US6863918B2 (en) | 1999-12-13 | 2005-03-08 | N.V. Nutricia | Infant formula with improved protein content |
JP2005139084A (ja) | 2003-11-04 | 2005-06-02 | Morinaga Milk Ind Co Ltd | システインプロテアーゼ阻害剤 |
KR20070034212A (ko) * | 2005-09-23 | 2007-03-28 | 윤영호 | 유청단백질 가수분해물을 유효성분으로 함유한 면역강화 또는 항산화용 건강기능식품 |
Non-Patent Citations (2)
Title |
---|
Separation of iron-binding protein from whey through enzymatic hydrolysis/(scienceDirect/Sang Bum Kim et al./Available online 6 December 2006) |
유청단백질의 효소 가수분해 및 그 분해물의 생리기능성/충남대 대학원 박사학위 논문/2004. 08/강수철 |
Also Published As
Publication number | Publication date |
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KR20080082041A (ko) | 2008-09-11 |
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