KR100684554B1 - Apparatus and process for manufacturing of O-15-water, which is characterized by reusing N of the mass number 15 - Google Patents

Abstract

As shown in FIG. 1, the present invention provides a gas inlet 1, a target chamber 2 for irradiating accelerated protons, a diverter valve 3, a condensation tube 4, a heating and cooling device 5, and the like. ¹⁵ N consisting of a circulating pump 6, a connection to the directional valve (4 in FIG. 2) and an inlet (8, 9) for liquid or gas, and an outer tube (7) with outlet (10) A device for producing ¹⁵ O labeled water which can be reused and a method of producing ¹⁵ O labeled water using the same.

O-15-Water Production Equipment, O-15-Water Production Method

Description

Apparatus and process for manufacturing of O-15-water, which is characterized by reusing N of the mass number, characterized by reusing N having a mass number of 15 15}

1 Example of a production apparatus for water labeled with ¹⁵ O to reuse ¹⁵ N. FIG.

2 is a method of connecting a directional valve having the same structure as a sample injection valve used in high pressure liquid chromatography (HPLC).

3. Example of a device in which the directional valve has a structure like a solenoid valve.

Explanation of symbols for main parts of the drawings

1: gas inlet, 2: target chamber, 3: directional valve, 4: condensation tube, 5: heating and cooling machine, 6: circulation pump, 7: external tube, 8: liquid inlet, 9: gas Inlet, 10: outlet

The present invention relates to a device for producing water labeled with ¹⁵ O while recovering and reusing the expensive ¹⁵ N nitrogen gas without throwing it away after use, and to a method for producing water labeled with ¹⁵ O using the device.

Refers to the ¹⁵ O water is positron emitting radioactive nuclear species, labeled with ¹⁵ O labeled water. It is medically used to image blood flow in the brain or myocardium. To produce it, you must first make ¹⁵ O. When this manufacturing method is the most widely used is a method of irradiating an accelerated deuterium nuclei in a particle accelerator consisting of a nitrogen gas ¹⁴ N. This method, however, the ¹⁵ O generally uses a particle accelerator using only a proton, by irradiating the protons accelerated by the nitrogen gas consisting of ¹⁵ N which due to the need for expensive particle accelerators to accelerate the deuterium nuclei Can produce. However, the ¹⁵ N nitrogen gas used at this time was tens of thousands of times more expensive than the ¹⁴ N nitrogen gas, and thus had a problem that it could not be widely used.

The present invention was devised to provide an apparatus for producing water labeled with ¹⁵ O and a production method using the same while recovering and reusing the expensive ¹⁵ N nitrogen gas without using it after use to solve the above problems.

The present invention relates to a device for producing water labeled with ¹⁵ O while recovering and reusing the expensive ¹⁵ N nitrogen gas without throwing it away after use, and to a method for producing water labeled with ¹⁵ O using the device.

In the present invention, the apparatus for producing water labeled with ¹⁵ O for reusing ¹⁵ N includes a gas inlet 1, a target chamber 2 for irradiating accelerated protons, and reorientation. Valve (3), condensation pipe (4), heating and cooler (5), circulation pump (6), connection to the directional valve (4) in Fig. 2, and inlets (8, 9) of liquid or gas, and outlet It consists of the external pipe | tube 7 provided with (10). It can be used more effectively when the outer tube is equipped with liquid and gas inlets 8 and 9 simultaneously.

In the above devices, the circulation pump 6 should be able to circulate the gas as a piston or rotary wing pump and be well sealed. In addition, the direction switching valve (3) having the same structure as the sample injection valve used when injecting a sample in high-speed liquid chromatography (HPLC) (Fig. 2) or having the same structure as the solenoid valve (Fig. Use any one of 3). In addition, the heating and the cooler 5 refers to a device that can heat the condensation tube 4 by blowing a heating wire or hot air, or cooling by flowing a cooling gas. And the condensation tube 4 can be used a variety of materials, it is preferable to use stainless steel.

In the present invention, the method for producing ¹⁵ O labeled water to reuse ¹⁵ N is as follows.

When using the same structure as the sample injection valve used when injecting a sample from the high-speed liquid chromatography (HPLC) to the direction switching valve in the apparatus as shown in Figure 1 (FIG. 2), first, the direction switching valve ( 3) The connecting direction of Fig. 2 is as shown in Fig. 2, and the target gas ( ¹⁵ N nitrogen gas containing 0.001 to 50% by volume of hydrogen) is put into the target chamber 2 and accelerated by a particle accelerator. Irradiation of one proton yields water labeled with ¹⁵ O. This is circulated by the circulation pump 6 to pass through the cooled condensation tube 4. The water labeled with ¹⁵ O is then condensed in the condensation tube 4 cooled by the heat and cooler 5 and the other gas components continue to circulate back into the target chamber 2. At this time, it is preferable to circulate the target gas in an amount of 0.1 to 5 L / min, and if the protons accelerated by the particle accelerator are continuously irradiated, the amount of water labeled with ¹⁵ O gathered in the cooled condensation tube is gradually increased. The amount can be monitored with a radiometer. When sufficient radiation accumulates, the proton irradiation is stopped, the circulation pump is stopped, and the directional valve is operated to separate the condensation tube from the whole system as shown in FIG. To be connected. Heating the condensation tube with a heater raising the temperature above 0 ℃ then injected with normal saline with a syringe to collect the labeled with ¹⁵ O water. To heat the water labeled with ¹⁵ O Condensation In this step, a heater raising the temperature above 0 ℃ following, may also be used a method of recovering an inert gas blown, in this case the water labeled with ¹⁵ O from the condenser is different Recovered by condensation on cooling vials. Then, physiological saline is injected to recover water labeled with ¹⁵ O, and the remaining physiological saline is removed by blowing inert gas or hydrogen. At this time, by removing the physiological saline remaining in the condensation tube by flowing an organic solvent, such as alcohol or acetone, the physiological saline can be removed faster by evaporating the organic solvent by blowing inert gas or hydrogen. If necessary, change the position of the diverter valve as shown in FIG. 2 again, start the circulation pump and irradiate the proton beam.

Even when a combination of the same structure as that of the three-way solenoid valve shown in FIG. 3 (FIG. 3. 3) is used as the directional valve, the same method as described above with the condenser tube connected to the entire system by operating the directional valve at first. Process to produce ¹⁵ O-labeled water, and when the required amount of ¹⁵ O-labeled water is produced in the cooled condenser tube, stop proton irradiation, stop the circulation pump, and change the direction. By operating the valve, the condensation tube is separated from the whole system to be connected to an external tube, and in the same manner as above, the ¹⁵ O labeled water is recovered and the physiological saline remaining in the condensation tube is removed. If necessary, operate the reversing valve again so that the condensation tube is connected to the whole system, then start the circulation pump and irradiate the proton beam.

Device and it the water method for producing labeled with ¹⁵ O with the present invention is also the ¹⁵ low hayeoseo using a particle accelerator to accelerate only protons if it is possible to recover and re-use is discarded after use of the expensive ¹⁵ N nitrogen gas Makes it possible to produce water labeled with O. Accordingly, the deuterium nucleus acceleration function, which has always been considered when introducing the particle accelerator, can be excluded in many cases, and research in the brain, cardiac blood flow function, etc. is expected to be performed more economically.

Claims (8)

A gas inlet for injecting target gas ( ¹⁵ N nitrogen gas containing 0.001 to 50% by volume of hydrogen) and a target chamber that produces ¹⁵ O-labeled water by irradiating the accelerated protons mounted on the particle accelerator. Valve and circulation pump is connected in an annular shape, If you operate the particle accelerator while operating the circulation pump, ¹⁵ O labeled water continues to be produced and circulated. By using a directional valve to change the direction of the gas circulating inside to flow to the condensation tube, By using the heating and the cooler connected to the condenser tube, the condenser tube is cooled down to 0 ° C. and only ¹⁵ O-labeled water is condensed, and the other target gas is continuously circulated by the circulation pump. The target gas containing expensive ¹⁵ N gas is recovered and reused through the gas inlet to the target chamber. It has a structure consisting of an external tube having a connection part with a directional valve, a liquid inlet, a gas inlet, and an outlet. The water labeled with ¹⁵ O condensed in the condensation tube is liquefied by raising the temperature of the condensation tube to a temperature of 0 ° C. or higher and 100 ° C. or lower using a heating and cooling machine. It is possible to collect through The remaining physiological saline is also removed by washing with alcohol or acetone through the liquid inlet, Alcohol tubes remain inside or acetone is ¹⁵ O reusing a ¹⁵ N, characterized in that to be given to blow an inert gas and hydrogen through the gas inlet evaporated to recover the ¹⁵ O-labeled water by connecting to the original annular back Device for producing water labeled with. The method of claim 1, wherein the directional valve has the same structure as the sample injection valve used when injecting the sample from the high-speed liquid chromatography (HPLC) (FIG. 2) or the same structure as the solenoid valve (FIG. 3). A device for producing water labeled with ¹⁵ O to reuse ¹⁵ N, characterized in that it is selected from. The method of claim 1, wherein the water production device labeled with ¹⁵ O ¹⁵ N to reuse the liquid and the gas inlet of the outer cylinder is installed. The method of claim 1 wherein the condensation tube of the water production device labeled with ¹⁵ O ¹⁵ N reusing made of stainless steel. Using the apparatus of claim 1, operating a directional valve to connect ¹⁵ N gas containing hydrogen with accelerated protons to produce water labeled with ¹⁵ O while the entire system and the condensation tube are connected; Circulating the produced ¹⁵ O-labeled water and residual gas with a circulating pump to condense the ¹⁵ O-labeled water into a cooled condenser tube and circulate the remaining gas components back into the target chamber; Collecting ¹⁵ O-labeled water into a cooled condenser tube while continuing to irradiate the circulating residual gas with accelerated protons, and stopping the operation of the proton irradiation and the circulating pump if the required amount is obtained; By operating the directional control valve raise the temperature of the condensing pipe and to connect the pipe connected to the outside away from the entire system, by heating the condensate pipe to the heater in a range from 0 ℃ 100 ℃ then, by injecting a saline solution into the syringe ¹⁵ recovering the water labeled with O and a method of production of water covers the residual saline in ¹⁵ O ¹⁵ N of reusing comprises the step of removing by blowing an inert gas or hydrogen. The method of producing ¹⁵ O-labeled water for reusing ¹⁵ N according to claim 5, wherein the ¹⁵ N gas containing hydrogen is circulated in an amount of 0.1 to 5 L / min. 6. The method of claim 5, in ¹⁵ O reusing ¹⁵ N, characterized in that the recovery of raising the temperature by heating the condensate pipe to the heater in a range from 0 ℃ 100 ℃ then, the blowing of the inert gas labeled with ¹⁵ O water Method of producing labeled water. The method of claim 5, wherein after recovering the water labeled with ¹⁵ O to remove residual physiological saline by flowing alcohol or acetone first, and to reuse ¹⁵ N characterized in that the evaporation of the organic solvent by blowing inert gas or hydrogen. Process for producing water labeled with ¹⁵ O.

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