JPH05119197A - Manufacture device and automatic injector of h215o - Google Patents

Abstract

PURPOSE:To obtain a safe and efficient automatic injector and device for producing injected liquid in the case where short half-life H2<15>O gas is used as the injected liquid. CONSTITUTION:The injection liquid manufacture device 5 has a collection bottle 51 fitted with a physiological salt solution for blowing into bubble H2<15>O gas just after H2<15>O gas is produced in a target box and an RI detector 56 for detecting H2<15>O gas contained in the physiological salt solution in the collection bottle 51 are equipped. The automatic injector 6 has a cylinder 66 for pressure- sending the injection liquid produced in the collection bottle 51 to an injection needle 64, three-way valves 61, 62, 65, which is provided between the collection bottle 51 and the cylinder 66 and between the cylinder 66 and the injection needle 64, for changing the flow direction of the injection liquid, a bubble detector 68a provided between the three-way valve 62 and the injection needle 64, another bubble detector 68 provided between the collection bottle 51 and the three-way valve 61 and a micropore filter 63 are equipped.

Description

Detailed Description of the Invention

[0001]

The present invention relates to a radioactive isotope (hereinafter R
I)), and more particularly to a manufacturing device and an injection device for using RI having a short half-life as an injection solution.

[0002]

2. Description of the Related Art Conventionally, a system for taking up into a living body by an inhalation method as a ¹⁵ O type RI gas has been used.

Further, conventionally, when H ₂ ¹⁵ O gas is used as an injection solution, ¹⁵ O ₂ gas is heated with platinum or palladium as a catalyst, and the ¹⁵ O ₂ gas passes through the catalyst. At that time, H ₂ gas was also passed through to synthesize H ₂ ¹⁵ O, and the steamed compound was bubbled into physiological saline to be injected as an injection drug.

[0004]

However, when the former gas is used, since the mask gas is inhaled, there is leakage of RI gas from the mask, and the positron emission tomography apparatus (PE) is used.
The background and stability against T) may be impaired, and since RI gas is absorbed into the blood vessels from the lungs, the inhalation time is long and the exposure is large.

Further, since the above-mentioned ¹⁵ O type RI gas has a short half-life of about 2 minutes, a large amount of RI gas must be used in order to take it in as a gas from the lungs.
The worker's exposure was also high.

When used as the latter injection solution,
H ₂ ¹⁵ O had a short half-life and was inefficient.

The present invention solves the above problems by providing a safe,
An object is to provide an apparatus that can realize an efficient method.

[0008]

In order to solve the above-mentioned problems, 1) In a manufacturing apparatus of H ₂ ¹⁵ O, a target box 1 irradiated with a duhtron beam and the target box 1 as a raw material gas are used. A gas supply device 2 for supplying hydrogen gas and nitrogen gas, and a vacuum pump 3 for maintaining the target box 1 and the inside of the RI transfer pipe 4 in a vacuum state are provided.

2) In the injection liquid producing apparatus 5, the collection bottle 51 which is upside down and the physiological saline solution filled in the collection bottle 51 are immediately filled with H ₂ ¹⁵ O in the target box 1. H ₂ ¹⁵ O introducing pipe opened to a lower space in the collection bottle 51 for bubbling and bubbling, and H contained in the physiological saline in the collection bottle 51.
An RI detector 56 for detecting the content of ₂ ¹⁵ O is provided.

3) In the automatic injection device 6, a syringe 66 for sucking out the injection solution produced in the collection bottle 51 and pumping the injection solution to the injection needle 64, and the collection bottle 51.
Three-way valves 61, 62, 65 for changing the flow direction of the injection liquid between the syringe 66 and the syringe 66 and between the syringe 66 and the injection needle 64.
A bubble detector 68a is provided in the pipe between the three-way valve 62 and the injection needle 64 to detect the presence or absence of bubbles before the injection, and a micropore filter 63 is further provided. A bubble detector 68 for detecting the presence or absence of bubbles is provided in the pipe for sucking the injection liquid from 51.

4) H ₂ ¹⁵ produced by the nuclear reaction
RI of the injection solution is detected by detecting that O has been absorbed by physiological saline in the collection bottle 51 and has reached a predetermined radiation dose by measuring the radiation dose by the RI detector 56.
It is to detect the quantity.

5) Bubbles are detected by the bubble detector 68 in the pipe for sucking and transporting the injection solution synthesized in the collecting bottle 51 by the syringe 66, and bubbles are detected by the bubble detector 68a before injection. If so, the operation of the syringe 66 is stopped.

[0013]

As described above, the required amount of the injection solution can be prepared immediately before the injection, the injection can be immediately performed, and the living body can directly reach the affected area from the blood vessel. Compared with, the diagnosis time is reduced.

[0014]

EXAMPLE First, a method and apparatus for producing H ₂ ¹⁵ O will be described. FIG. 1 is a block diagram of an H ₂ ¹⁵ O manufacturing apparatus. This device includes a target box 1, a gas supply device 2, an RI transfer pipe 4, a target box 1 and an RI.
It is composed of a vacuum pump 3 for reducing the pressure inside the transfer pipe 4.

As the gas supply device 2, a raw material gas cylinder 21 in which H ₂ and N ₂ are mixed, a carrier gas cylinder 22 using He gas, and a pipe from these gas cylinders 21, 22 to the target box 1 are provided. The pressure regulator 23, the solenoid valve 24, and the solenoid valve 25 provided at the outlet of the source gas cylinder 21 and the solenoid valve 26 provided at the outlet of the carrier gas cylinder 22 are provided.

The target box 1 is attached to the RI transfer pipe 4.
A solenoid valve 41 is provided at the outlet of the solenoid valve 41.
After passing through the valve, it branches and passes through the solenoid valve 42 and the vacuum pump 3
Is connected, and the injection liquid manufacturing device 5 is further connected from this branch point.
It is connected to the solenoid valve 53. Since the RI gas having radioactivity passes through the inside of the RI transfer pipe 4, the outside is shielded from radioactivity.

Next, the operation (including the operating method) of the above H ₂ ¹⁵ O manufacturing apparatus will be described. First, the solenoid valve 25,
26 and the electromagnetic valve 53 in the injection liquid manufacturing apparatus 5 are closed, and the interior of the target box 1, the RI transfer pipe 4 and the like is vacuumed by the vacuum pump 3 and cleaned.

Next, the electromagnetic valve 42 is closed, the electromagnetic valve 25 is opened, and the target box 1 and the RI transfer pipe 4 are filled with the raw material gas. Perform cleaning.

After the cleaning is completed, the electromagnetic valve 41 is closed, the target gas having a predetermined pressure adjusted by the pressure regulating valve 23 is filled in the target box 1, and the electromagnetic valve 24 is closed to stand by.

The source gas in the target box 1 is irradiated with a deutron beam generated by a cyclotron at a required time. By this irradiation, the raw material gas causes the following nuclear reaction to generate H ₂ ¹⁵ O. That is,

[Equation 1]

After the irradiation, the electromagnetic valve 53 is opened, and the generated H ₂ ¹⁵ O is immediately conveyed to the injection solution manufacturing device 5. In this case, the H ₂ ¹⁵ O remaining in the target box 1 is completely transported to the injection liquid manufacturing device 5 by the helium gas in the transport gas cylinder 22.

Next, the injection liquid manufacturing apparatus 5 will be described.
This device is the one in the chain line in FIG.
1 and the upright liquid reservoir bottle 52, and the upper space in the collection bin 51 and the upper space of the liquid reservoir bottle 52 are connected by a conduit through the respective stoppers.

Further, the RI transfer pipe 4 is provided in the collection bottle 51.
A pipe penetrates the stopper from the solenoid valve 53 connected to and opens to the lower space inside, and a pipe to the automatic injection device 6 is provided through the stopper from the lower space.

On the other hand, the liquid reservoir bottle 52 is provided with a pipe connected to the three-way valve 54 in addition to the pipe from the collection bottle 51 penetrating the stopper. One of the two is connected to a micropore filter 55 and is configured to take in indoor air, and the other one is configured to discharge waste gas. Furthermore, the collection bottle 5
The RI detector 56 is provided in the vicinity of 1.

On the other hand, the automatic injection device 6 is the one within the chain line in the configuration diagram of the injection liquid manufacturing device and the automatic injection device of FIG. 2, and the three-way valve is formed by piping through the stopper from the lower space in the collection bottle 51. It is connected to 61. A three-way valve 62 is further connected to one of the other two sides of the three-way valve 61, and an injection needle 64 is connected to one of the three-way valve 61 via a micropore filter 63.
Are connected.

A three-way valve 65 is further connected to the other one of the three-way valves 62, a syringe 66 is connected to the other one of the three-way valves 65, and the waste liquid bottle 6 is connected to the other one.
Pipes up to 7 are connected.

Further, a bubble detector 68 is provided in the pipe between the three-way valve 61 and the collection bottle 51, and a bubble detector 68a is provided in the pipe between the three-way valve 62 and the micropore filter 63. An external saline tank 7 is connected to one of the three-way valves 61.

Next, the operation (operation) of the above-mentioned injection liquid manufacturing device 5 and automatic injection device 6 will be described. Each bottle 51 used in the above-mentioned injection solution manufacturing device 5 and automatic injection device 6,
52, 67 Syringe 66, injection needle 64, micropore filter 63, each three-way valve 61, 62, 65 and the pipes contacting the injection solution, all of the pipes other than the H ₂ ¹⁵ O introducing pipe are disposable parts.

3 to 9 are operation explanatory views of respective operations (steps) of the injection liquid manufacturing apparatus 5 and the automatic injection apparatus 6, and FIG. 11 is a flowchart of each step. Each operation (operation) will be described based on this flowchart.

Step 1: Replace each used part with a new one. The disposable parts are the collection bottle 51, the liquid storage bottle 52, the physiological saline solution tank 7, and the three-way valves 61, 62, 65 shown in FIG.
Syringe 66, waste liquid bottle 67, micropore filter 6
3, an injection needle 64 and pipes between them.

Step 2 (FIG. 3): Saline tank 7
The air from the pipes up to the waste liquid bottle 67 is evacuated by the self-weight drop from. This state is shown by the black portion in FIG. In the following, the flow parts of gas and liquid in each step are shown in black.

Step 3 (FIG. 4): Syringe driving device 6
6a for supplying physiological saline from the physiological saline tank 7 to the three-way valve 6
Suction into the syringe 66 via 1, 62, 65.

Step 4 (FIG. 5): The physiological saline aspirated in Step 3 is used by the syringe drive device 66a to set the three-way valve 65,
Air is removed from the piping through 62 to the injection needle 64. In this case, repeat steps 1 to 4 any number of times,
The air can be completely removed.

Step 5 (FIG. 6): The physiological saline is sucked from the physiological saline tank 7 into the syringe 66 via the three-way valves 61, 62 and 65.

Step 6 (FIG. 7): The physiological saline aspirated in Step 5 is transferred to the collection bottle 51 via the three-way valves 65, 62 and 61.

Step 7 (FIG. 8): H ₂ ¹⁵ O from the target box 1 via the RI transfer pipe 4 and the solenoid valve 53.
Is sent to the collection bin 51 together with the carrier gas. Collection bottle 5
Carrier gas other than H ₂ ¹⁵ O absorbed in 1 is stored in the liquid storage bottle 5
It is stored in a waste gas cylinder via a two-way valve 54.
During this feeding, the RI detector 56 detects the amount of H ₂ ¹⁵ O absorbed, and continues step 7 until it reaches a predetermined amount, and when it reaches a predetermined amount and becomes a predetermined injection solution, shifts to step 8. ..

Step 8 (FIG. 9): The injection solution in the collection bottle 51 is sucked by the syringe 66 via the three-way valves 61, 62 and 65 so that H ₂ ¹⁵ O is accumulated in the coil portion 69 of the pipe. .. In this case, since the pipe between the collection bottle 51 and the three-way valve 61 is configured to pass through the photoelectric bubble detector 68, the presence or absence of bubbles in the transferred injection liquid is detected, and the bubbles are detected. If not, the process proceeds to step 9, and if detected, the suction operation of the syringe 66 is stopped.

The injection liquid in the collection bottle 51 is stored in the syringe 6.
When the air is sucked into 6, the room air is the micropore filter 5
5, collection valve 51 via three-way valve 54 and liquid reservoir 52
To prevent depressurization in the collection bottle 51.

Step 9 (FIG. 10): H ₂ ¹⁵ O accumulated in the coil portion 69 reaches the injection needle 64 through the three-way valves 65 and 62 and the micropore filter 63 by the injection liquid sucked into the syringe 66, It is injected into a living body, but in this case, it is checked by a bubble detector 68a for detecting the presence or absence of bubbles.

In this case, since it is usual to repeat this several times in the clinical diagnosis of H ₂ ¹⁵ O, the air bleeding is omitted again,
The operation from step 5 can be repeated to shorten the time. When several times of administration are completed, a series of operations is finished.

After completion of the living body administration, or in advance, the following sampling can be performed as shown in the explanatory diagrams of the sampling steps shown in FIGS. 12 to 15 to perform a test for living body administration.

Step 11 (FIG. 12): Suction physiological saline into the syringe 66.

Step 12 (FIG. 13): Put physiological saline in the collection bottle 51.

Step 13 (FIG. 14): Suction from the collection bottle 51 to the syringe 66.

Step 14 (FIG. 15): If the three-way valve 70 is inserted between the micropore filter 63 and the injection needle 64, the sample can be taken by switching the three-way valve 70 without removing the injection needle 64 from the living body. I can. Of course, by pressing the sampling button
14 is operated automatically.

In each of the above steps, the solenoid valve 53 and the three-way valves 54, 6 can be operated by simply pushing the operation button of the control device (not shown).
Switching between 1, 62 and 65 and vertical movement of the syringe 66 can be automatically performed.

Further, since the injection liquid cannot be injected into the living body if there are air bubbles in the injection liquid, the collecting bottle 51 is used in step 8.
When the injection liquid is sucked from the syringe 66 into the syringe 66, the presence or absence of bubbles is detected by the photoelectric bubble detector 68, and if there are bubbles, the suction operation of the syringe 66 is stopped.

In step 9, when performing injection, the presence or absence of bubbles is checked by the bubble detector 68a, and if there are bubbles, the injection operation of the syringe 66 is stopped. When the above-mentioned operation occurs, it is sufficient to reset and start over from step 1. Further, the injection solution is subjected to air trap and germ treatment by the micropore filter 63 in front of the injection needle 64. Furthermore, since the injection speed of the syringe 66 is variable, the injection can be executed at a speed that matches the condition of the living body.

Since the half-life of the ¹⁵ O system is about 2 minutes, in order to make the injection time constant, after the injection liquid in step 8 is sucked into the syringe 66, the timer of the control device is counted down and the worker is informed. It is configured to facilitate the execution of the injection. This timer is variably set according to various conditions.

[0050]

As described above, the required amount of the injection solution can be prepared immediately before the injection, the injection can be immediately performed, and the living body can reach the affected area directly from the blood vessel.
Compared to the conventional gas inhalation method, the diagnostic time can be reduced.

For this reason, RI can be automatically injected into the living body under rapid and clean conditions, and the following effects are obtained.

1) Due to its rapidity, it does not take much time and it is not necessary to manufacture RI in large quantities with a cyclotron.

2) Since RI can be automatically injected without producing a large amount of RI, the exposure of the worker can be extremely reduced.

3) Direct injection into a living body reduces the time required for RI to reach the affected area via a blood vessel, shortens the diagnosis time, and significantly reduces the exposure of the living body. Until now, it was possible to make a diagnosis with ¹⁵ O-based gas only once, but since it can be made several times, the certainty of diagnosing a malignant tumor or the like can be enhanced.

4) Since the bubble detection of the injection solution is performed at two places, the worker can work with peace of mind.

5) Including a sampling step
The drug (H₂ ¹⁵O)
You can

[Brief description of drawings]

FIG. 1 is a configuration diagram of an H ₂ ¹⁵ O manufacturing apparatus.

FIG. 2 is a configuration diagram of an injection solution manufacturing device and an automatic injection device.

FIG. 3 Step 2 of the injection liquid manufacturing apparatus and the automatic injection apparatus
FIG. 7 is an explanatory diagram of an operating state of FIG.

FIG. 4 is an explanatory diagram of an operating state of step 3 of the same.

FIG. 5 is an explanatory diagram of an operating state of step 4 of the same.

FIG. 6 is an explanatory diagram of an operating state of step 5 of the same.

FIG. 7 is an explanatory diagram of an operating state of step 6 similarly.

FIG. 8 is an explanatory diagram of an operating state of step 7 of the same.

FIG. 9 is an explanatory diagram of an operating state of step 8 of the same.

FIG. 10 is an explanatory diagram of an operating state of step 9 of the same.

FIG. 11 is a flowchart of each step.

FIG. 12 is an explanatory diagram of an operation state of step 11 of the sampling step.

FIG. 13 is an explanatory diagram of an operating state of step 12 of the same.

FIG. 14 is an explanatory diagram of an operation state of step 13 similarly.

FIG. 15 is an explanatory diagram of an operating state of step 14 of the same.

[Explanation of symbols]

 1 Target Box 2 Gas Supply Device 3 Vacuum Pump 4 RI Transport Piping 5 Injection Liquid Manufacturing Device 51 Collection Bottle 56 RI Detector 6 Automatic Injection Device 61 Three-way Valve 62 Three-way Valve 63 Micropore Filter 64 Injection Needle 65 Three-way Valve 66 Syringe 68 Bubble Detection Device 68a bubble detector

 ─────────────────────────────────────────────────── ─── Continuation of front page (72) Inventor Matsutaro Murakami 6-10 Chiaki Kubota-cho, Akita-shi, Akita Prefecture Akita Prefectural Cerebrovascular Research Center (72) Inventor Youjiro Toda, No. 4, Chazu-cho, Muroran-shi, Hokkaido Japan Steel Mfg. Co., Ltd. In-house (72) Inventor Di Sugawara 4 Chazu-cho, Muroran-shi, Hokkaido Inside Japan Steel Works

Claims (5)

[Claims] 1. An H ₂ ¹⁵ O manufacturing apparatus, a target box irradiated with a deutron beam, a gas supply apparatus for supplying hydrogen gas and nitrogen gas as source gases to the target box, the target box and An apparatus for producing H ₂ ¹⁵ O, which is provided with a vacuum pump for holding the inside of the radioactive isotope transfer pipe in a vacuum state. 2. In an injection solution manufacturing apparatus, bubbling is performed by injecting an inverted collection bottle and H ₂ ¹⁵ O immediately after being manufactured in the target box into a physiological saline solution filled in the collection bottle. An H ₂ ¹⁵ O introducing pipe opened to a lower space in the collection bottle for restraining the radioactivity and a radioisotope for detecting the content of H ₂ ¹⁵ O contained in the physiological saline in the collection bottle. An injectable solution manufacturing apparatus, which is provided with a detector. 3. In an automatic injection device, a syringe for sucking the injection solution produced in the collection bottle and pumping the injection solution to an injection needle, and between the collection bottle and the syringe and between the syringe and the injection needle. A three-way valve that changes the flow direction of the injection solution, a micropore filter provided in the pipe between the three-way valve and the injection needle, and a living body for detecting the presence or absence of bubbles in the pipe that sucks the injection solution from the collection bottle. An automatic injection device, which is provided with a bubble detector for detecting the presence or absence of bubbles before being injected into. 4. The fact that H ₂ ¹⁵ O produced by a nuclear reaction is absorbed by physiological saline in the collection bottle and reaches a predetermined radiation dose is detected by measuring the radiation dose by a radioisotope detector. A method for detecting the amount of RI in an injectable solution, which comprises: 5. The bubble is detected by a bubble detector in a pipe for sucking and transporting the injection solution synthesized in the collection bottle by the syringe, and the bubble is detected by a bubble detector provided in a pipe in front of the injection needle. A method for detecting the presence / absence of bubbles in an injectable solution, characterized by performing double detection by performing detection and stopping operation of the syringe when bubbles are detected.