KR100630240B1 - Cosmetic composition for increase of sebum excretion and opening of follicular occlusion in acne - Google Patents

Abstract

The present invention relates to a composition for improving acne and increasing the secretion of acne and opening the clogged pores in the closure of the pores, to increase sebum secretion in the open pores to improve acne and a cosmetic comprising the same. More specifically, salicylic acid and triclosan (triclosan) and trihydroxy palmitic acid containing acne to open the closed pores and to promote sebum secretion through the open pores to improve the inflammatory symptoms of acne.

To this end, the present invention relates to a composition containing salicylic acid 500 parts and triclosan 300 and trihydroxy palmitic acid part 200 to open the closed pores in acne and promote sebum secretion to improve the inflammatory symptoms of acne.

Acne * Pore closure * Salicylic acid * Triclosan * Trihydroxy palmitic acid

Description

Cosmetic composition for increasing sebum secretion and promoting sebum secretion in acne and cosmetics comprising the same {Cosmetic composition for increase of sebum excretion and opening of follicular occlusion in acne}

The present invention relates to a composition for opening pores closed in acne and promoting sebum secretion and a cosmetic comprising the same. More specifically, it relates to a composition containing salicylic acid 500 parts and triclosan 300 and trihydroxy palmitic acid part 200 to open the closed pores in acne and promote sebum secretion and a composition comprising the same.

1) What is acne?

Acne is a chronic inflammatory disease of the fur branch in the skin appendages. It is a very common skin disease that most commonly occurs in puberty and early adulthood. It usually occurs in puberty and is lost in the mid-20s, but it can occur regardless of age, and can occur from newborn to around 70 years old. It depends on the author, but in many cases, the entire population (100%) suffers from acne mildly or severely, and in general, 80% of people suffer from acne at least once. It usually lasts 3-5 years, but in severe cases it can last for decades.

2) Clinical aspects of acne

Acne lesions are very diverse. The primary lesion of acne is comedo. The scleroderma is produced by stagnation of keratin and sebum under the pores due to hyperkeratosis of the follicle epithelium. As acne progresses, papules, pustules, cysts, and nodules appear, and in a patient they may appear complex.

3) the onset of acne

Although the exact cause of acne is not known, various factors are involved and symptoms are known to be caused by the interaction of various factors. The four components of acne development, (1) increased sebum secretion, (2) abnormally increased hair follicle hyperkeratosis and pore closure, (3) acne bacteria proliferation, and (4) inflamed inflammation.

A) sebum increase and androgens

Acne patients usually have oily skin and a higher amount of sebum than normal people. It is known that there is a close relationship between the severity of acne and sebum secretion, and the increase in sebum secretion is closely related to androgen, an androgenic hormone. Many other factors, especially corticosteroids, gonadotropins, thyroid hormones, and other steroids and steroids are involved in sebaceous glands, but the most important is androgen, a male hormone. Circulating androgens in the body are activated by binding to receptors for androgen in sebaceous cells of the sebaceous gland, increase the cell division of sebum cells and secrete a lot of sebum.

In addition to stimulating sebaceous glands to increase sebum secretion, androgens stimulate pore intake keratinocytes to induce pore closure. With the increase of sebum secretion, keratinization of the pores keratinocytes clogs pores and sebum accumulates. The closure of the pores is further intensified by the changed sebum component. In summary, androgens cause acne because they make more sebum in the sebaceous glands and also block the pores, the exit of sebum.

B) the amount of androgenic and estrogen

Does a lot of sebum secretion have a lot of androgenic? The answer is not. Most of them (5% increase in androgenic levels only) have no change in the amount of androgenic hormones, and are closely related to the sensitivity of the sebaceous gland distribution to the changes in the hormones.

In other words, patients with severe acne, even a very small change in the hormone sebum secretion increases a lot and acne worsens. Looking at the relationship between sebum secretion and estrogen, the decrease in sebaceous gland size and sebum secretion can be observed when the female estrogen is administered to both men and women. However, in order to have such an effect, a larger amount of blood estrogen should be administered in a normal person, so males may have side effects such as feminization. The effect of estrogen on sebaceous glands is not indirect but rather indirect by reducing the release of androgens, which are relatively androgenic. Recently, there is a product that expands the acne treatment effect of the estrogen preparation developed as a contraceptive and explains it as a contraceptive for women with acne.

C) pore closure due to sebum change

Increased sebum caused by androgens and other causes of acne is caused by hormones and acne bacteria to change the lipid components that make up sebum. Cholesterol decreases with linoleic acid of acylceramide. Squalene and free fatty acids increase. Reduction of cholesterol leads to an imbalance between cholesterol and cholesterol sulfate in hair follicles, which promotes binding between keratinocytes in hair follicles, and increased free fatty acids stimulate hair follicle openings, leading to follicular wall hyperkeratosis. This leads to clogging of the pores, which results in the propagation of the anaerobic bacterium Propionibacterium acnes . These bacteria gather inflammatory cells to form pustules and cause inflammation. In other words, inflammatory acne will occur.

D) Role of Acne Bacteria ( Propionibacterium acnes )

Among the basic causes of acne, the role of acne bacteria is known to be very important in addition to sebum increase and clogged follicle wall hyperkeratosis. Acne bacteria ( Propionibacterium acnes ) secrete lipolytic enzymes and chemotactic factors. Lipolytic enzymes produce free fatty acids and cause follicular wall hyperkeratosis, and chemotactic factors cause inflammatory cells to collect around hair follicles. Free fatty acids and inflammatory cells stimulate and destroy the hair follicle wall, causing the hair follicle contents to leak into the dermis, resulting in inflammatory and foreign body reactions by sebum and inflammatory cells.

E) Inflammation

Most acne sufferers have an inflammatory response. When acne is accompanied by an inflammatory response, it is accompanied by scarring and pigmentation, which provides a justification for all inflamed acne to be treated. Why does inflammation occur? There are many causes, but the most important is the induction of inflammation caused by acne bacteria in the condition of increased sebum and clogged pores. This is the basic reason for the use of antibiotics early in acne treatment (referred to later in the treatment), which is always clinically experienced, but sebum and acne bacteria leak into the skin when acne is mishandled or damaged. Becomes more severe, and severe inflammation leaves scars and pigmentation.

F) other causes

It is known that abnormalities in skin barrier, food, menstruation, seasonal changes, and cosmetics may be involved in the development or worsening of acne.

(5) Cosmetics: Cosmetics can cause acne. Kligman and Mills said about one-third of American women experienced acne by using cosmetics containing lanolin, petrolatum, some vegetable oils, butyl stearate, lauryl alcohol, and oleic acid. In other words, people who use a lot of milk ingredients can cause a lot of acne. Therefore, I would recommend oil-based cosmetics that do not contain oil in the case of people who have a lot of acne where possible.

Cosmetics have been used for cosmetic purposes to make skin brighter and clearer, but its efficacy and effectiveness are scientifically recognized and recognized as functional cosmetics. Nowadays, the trend is to expand the area to the therapeutic part that can play an important role in the prevention and symptom improvement of disease while having efficacy and effect in addition to cosmetic purpose. Kligman and Mills reported that one-third of American women experienced acne outbreaks using cosmetics containing lanolin, petrolatum, some vegetable oils, butyl stearate, lauryl alcohol, and oleic acid. There is a cause for suppression of In other words, people who use a lot of milk ingredients can cause a lot of acne. Therefore, the composition that opens the pores and promotes sebum secretion and cosmetics containing the same is indispensable for symptom improvement.

The present invention provides a mixture of active ingredients that promote sebum secretion by improving pore closure in a conventional cosmetic composition under the concept of opening the closed pores in acne and promoting sebum secretion to improve the symptoms of acne. There is this. In order to achieve this purpose, it is possible to improve pore blockage and sebum secretion by using a combination of salicylic acid having exfoliating effect, triclosan having sebum control and antibacterial effect, and trihydroxy palmitic acid having anti-inflammatory and calming effect. It has been found that there is an promoting effect and the present invention has been completed.

Therefore, an object of the present invention is to provide a composition and a cosmetic comprising the same having the effect of improving the inflammatory symptoms of acne by opening the closed pores in acne and promoting sebum secretion.

In order to achieve the above object, a composition for improving the inflammatory symptoms of acne by opening the closed pores and promoting sebum secretion in acne according to the present invention and cosmetics comprising the same salicylic acid 500 parts by weight and triclosan 300 and trihydroxy It is characterized by containing 200 parts by weight of palmitic acid (trihydroxy palmitic acid).

Hereinafter, the present invention will be described in more detail.

The composition of the present invention contains 500 parts salicylic acid.

Salicylic acid corresponds to o-oxybenzoic acid. Formula C ₇ H ₆ O ₃ . Molecular weight 138.12, sublimable, soluble in organic solvents such as ether ethanol. It is acidic and also phenolic, making it purple when an aqueous solution of iron (III) chloride is added. It has the strongest peeling effect with 14% content in 99.9% ethanol aqueous solution and is used as a dermatologically artificial chemical dermabrasion preparation. It is specified to include 0.5% or less in cosmetics.

The composition of the present invention contains triclosan 300.

Triclosan (2,4,4'-Trichloro-2'-hydroxydiphenyl ether) is an ether containing a halogenated compound having the formula C ₁₂ H ₇ CL ₃ O ₂ , molecular weight 289.55. It is commonly used in cosmetics, toothpaste, kitchen utensils, etc., and has been used widely for the past 30 years for the bactericidal effect against microorganisms such as bacteria and molds.

Trihydroxy palmitic acid has a molecular weight of 304 and is also referred to as 9,10,16-trihydroxyhexadecanoic acid (9,10,16-trihydroxyhexadecanoic acid) and aleuritic acid.

In the present invention, a composition which improves pore blockage in acne and promotes sebum secretion in the improvement of inflammatory diseases of the hair follicles such as periarthritis, folliculitis, injection is not particularly limited in the formulation. For example, it may be a cosmetic composition having a flexible cosmetic water, nutrient cream, massage cream, nourishing cream, pack, gel or adhesive formulation. In addition, in the external preparation composition of each formulation, the components other than the salicylic acid 500 parts by weight and triclosan part 300 parts by weight and trihydroxy palmitic acid part by weight 200 are different according to the formulation or purpose of use of other cosmetic compositions. You can mix and match enemies without difficulty.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to the following Examples.

<Comparative Examples 1 to 4 and Examples 1 to 4>

The components 17, 12, 13, and 14 were mixed and the temperature was adjusted to 70 ° C (sample 1). Components 1, 2, 3, 4, 5, 6, 7, 8, and 9 were mixed, and components 10 and 11 were mixed in Comparative Examples 2 to 3 and Examples of Table 1 to adjust the temperature to 70 ° C. (Sample 2 ). Sample 2 was added to Sample 1, emulsified at 3600 rpm / 3 minutes, the temperature was lowered to 50 ° C. with cooling water, and in the case of Comparative Example 4 and Example, only Component 15 was added and stirred well, followed by 30 ° C. Cooled to.

The component ratios of Comparative Examples 1 to 4 and Examples 1 to 4 are summarized in Table 1.

TABLE 1

Test 1 Inhibitory effect of hyperkeratosis in hairless mice

According to a study that skin hyperkeratosis induces pore closure, 100 μl of oleic acid was applied once a day to induce skin irritation and hyperkeratosis in hairless mice aged 8-12 weeks. The control group was applied only oleic acid for 7 days. After applying the oleic acid for 7 days, the test group applied 100 μl of Comparative Examples 1 to 4 and Examples 1 to 4 for 7 days. After 7 days from the start of the test, the outermost stratum corneum was separated by D-squame tape from the embryos of hairless mice, and the image was stored on the tape with BMI's Image analyzer program BMI after storing the image with a CCD camera. The amount of keratin was quantified to assess the degree of hyperkeratosis. The hyperkeratosis inhibition rate used in the efficacy evaluation was calculated as shown in Equation 2 as a relative amount with the amount of keratin produced by oleic acid as 100 after calculating the amount of each keratin. The results are shown in FIGS.

[Equation 1]

<Experiment result>

Looking at the results of Table 2, the effect of inhibiting hyperkeratosis is increased when these components are mixed (Examples 1, 2, 3, 4) than when each component is used as an active ingredient (Comparative Examples 2, 3, 4). Appeared to be.

<Test Example 2> Sebum reduction effect through human experiment

The sebum reducing efficacy of the cosmetics prepared in Table 1 was compared. Changes in sebaceous secretions were measured in 10 adults with strong sebaceous secretions aged 16 to 25 years. The test method is as follows. Using sebometer (Sebometer Courage + Khazaka, Cologne, Germany) as the test site, the sebum secretion level before application is the default, and eight sites are randomly selected and uncoated areas, Comparative Examples 1 to 4, After application of Examples 1 to 4, the sebum secretion effect was measured by measuring the change of sebum secretion after 2, 4, 8 hours, and the changed sebum secretion compared to the initial value was calculated as shown in Equation 2. Is shown in Table 4.

[Equation 2]

TABLE 3

<Experiment result>

As shown in Table 2, in the sebum reduction effect, the mixing composition of Example 4 was found to increase the effect the most.

Experimental Example 3 Measurement of Cotton Cloth Reduction Effect in Acne

For the cosmetics prepared in Example 4 and Comparative Example 1 of Table 1, the change in the number of cotton cloth was measured in 20 subjects having acne. The test method is as follows.

Subjects were randomly divided into two sets, each of which was given Example 4 and Comparative Example 4, and applied to the face twice daily for four weeks. Before the start of the test and after 4 weeks of application, the number of cotton cloths was measured at the test site to evaluate the acne improvement effect of the sample and the results are shown in Table 4. The effect of improving the cotton cloth on acne was calculated using the number of cotton cloths in Equation 3.

[Equation 3]

[Table 4] Cotton cloth improvement rate

<Experiment result>

In Table 4, it can be seen that the application of the mixed composition of the fourth embodiment is excellent in suppressing cotton cloth on the skin of acne.

 As described above, the cosmetic composition provided by the present invention is mixed with salicylic acid of formula (1), triclosan of formula (II), and trihydroxypalmitic acid of formula (III) in a weight part 5: 3: 2. It can be seen that the synergistic effect is to improve pore blockage and promote sebum secretion in acne than when used alone or two other compounds.

Claims (1)

It contains salicylic acid of formula (I), triclosan of formula (II), and trihydroxypalmitic acid of formula (III) in a weight part of 5: 3: 2 to improve the pore blockage of acne and promote sebum secretion. Cosmetic composition showing. Structural Formula I

Structural Formula II

Structural Formula III