KR100611854B1 - 신경 펩타이드 ｙ(ｎｐｙ) 수용체 길항제로서의 티아졸유도체 - Google Patents
신경 펩타이드 ｙ(ｎｐｙ) 수용체 길항제로서의 티아졸유도체 Download PDFInfo
- Publication number
- KR100611854B1 KR100611854B1 KR1020047013315A KR20047013315A KR100611854B1 KR 100611854 B1 KR100611854 B1 KR 100611854B1 KR 1020047013315 A KR1020047013315 A KR 1020047013315A KR 20047013315 A KR20047013315 A KR 20047013315A KR 100611854 B1 KR100611854 B1 KR 100611854B1
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- thiazol
- ylamino
- benzoyl
- propyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- ASJLBFWOCHGXBO-UHFFFAOYSA-N CC(C)(C)OC(NCCCCCN=S)=O Chemical compound CC(C)(C)OC(NCCCCCN=S)=O ASJLBFWOCHGXBO-UHFFFAOYSA-N 0.000 description 1
- ZMZRUMCPNAJPPN-OQLLNIDSSA-N CC(C)(C)OC(NCCCNC(/N=C/N(C)C)=S)=O Chemical compound CC(C)(C)OC(NCCCNC(/N=C/N(C)C)=S)=O ZMZRUMCPNAJPPN-OQLLNIDSSA-N 0.000 description 1
- MCXNPYKTIYZKRN-UHFFFAOYSA-N CC(C)(C)OC(NCCNc1ncc(C(c2c(C)cccc2)=O)[s]1)=O Chemical compound CC(C)(C)OC(NCCNc1ncc(C(c2c(C)cccc2)=O)[s]1)=O MCXNPYKTIYZKRN-UHFFFAOYSA-N 0.000 description 1
- NMMKMDDAVQJVGL-UHFFFAOYSA-N CCS(NCCCNc1ncc(C(c2c(C)cccc2)=O)[s]1)(=O)=O Chemical compound CCS(NCCCNc1ncc(C(c2c(C)cccc2)=O)[s]1)(=O)=O NMMKMDDAVQJVGL-UHFFFAOYSA-N 0.000 description 1
- XQOKYIVYUQSLAC-FRKPEAEDSA-N Cc1c(C(c2cnc(/N=C/CCN)[s]2)=O)nccc1 Chemical compound Cc1c(C(c2cnc(/N=C/CCN)[s]2)=O)nccc1 XQOKYIVYUQSLAC-FRKPEAEDSA-N 0.000 description 1
- WUPWWMXYQFNPOB-UHFFFAOYSA-N Cc1ccccc1C(c1cnc(NCCCNC)[s]1)=O Chemical compound Cc1ccccc1C(c1cnc(NCCCNC)[s]1)=O WUPWWMXYQFNPOB-UHFFFAOYSA-N 0.000 description 1
- HXSYGKICCSRBIB-UHFFFAOYSA-N NCCCCCNc1ncc(C(c2ccncc2)=O)[s]1 Chemical compound NCCCCCNc1ncc(C(c2ccncc2)=O)[s]1 HXSYGKICCSRBIB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02004296 | 2002-02-28 | ||
| EP02004296.6 | 2002-02-28 | ||
| PCT/EP2003/001667 WO2003072577A1 (en) | 2002-02-28 | 2003-02-19 | Thiazole derivatives as npy receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20040094735A KR20040094735A (ko) | 2004-11-10 |
| KR100611854B1 true KR100611854B1 (ko) | 2006-08-11 |
Family
ID=27763338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047013315A Expired - Fee Related KR100611854B1 (ko) | 2002-02-28 | 2003-02-19 | 신경 펩타이드 ｙ(ｎｐｙ) 수용체 길항제로서의 티아졸유도체 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6686381B2 (https=) |
| EP (1) | EP1480976B1 (https=) |
| JP (1) | JP2005526732A (https=) |
| KR (1) | KR100611854B1 (https=) |
| CN (1) | CN100363362C (https=) |
| AR (1) | AR038704A1 (https=) |
| AT (1) | ATE373654T1 (https=) |
| AU (1) | AU2003210305B2 (https=) |
| BR (1) | BR0308108A (https=) |
| CA (1) | CA2475299A1 (https=) |
| DE (1) | DE60316411T2 (https=) |
| ES (1) | ES2292992T3 (https=) |
| GT (1) | GT200300045A (https=) |
| MX (1) | MXPA04008379A (https=) |
| PA (1) | PA8567301A1 (https=) |
| PE (1) | PE20030930A1 (https=) |
| PL (1) | PL372463A1 (https=) |
| RU (1) | RU2004129285A (https=) |
| TW (1) | TW200403995A (https=) |
| UY (1) | UY27689A1 (https=) |
| WO (1) | WO2003072577A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| RU2006107444A (ru) | 2003-08-12 | 2007-09-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | 2-амино-5-бензоилтиазолы в качестве антагонистов npy |
| RU2321586C2 (ru) * | 2003-08-12 | 2008-04-10 | Ф.Хоффманн-Ля Рош Аг | Производные тиазола в качестве антагонистов npy |
| WO2005058887A1 (en) * | 2003-12-08 | 2005-06-30 | F. Hoffmann-La Roche Ag | Novel thiazole derivates |
| AU2005236055B2 (en) * | 2004-04-20 | 2011-10-06 | Transtech Pharma, Llc | Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators |
| FR2884516B1 (fr) * | 2005-04-15 | 2007-06-22 | Cerep Sa | Antagonistes npy, preparation et utilisations |
| WO2007084391A2 (en) * | 2006-01-18 | 2007-07-26 | Amgen Inc. | Thiazole compounds as protein kinase b ( pkb) inhibitors |
| WO2010098298A1 (ja) * | 2009-02-27 | 2010-09-02 | 塩野義製薬株式会社 | 栄養素の消化吸収抑制作用を有する化合物とシクロヘキサンカルボキサミド誘導体を組み合わせてなる医薬組成物 |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| CN118416236A (zh) | 2018-01-31 | 2024-08-02 | 德西费拉制药有限责任公司 | 治疗胃肠道间质瘤的组合疗法 |
| IL276398B2 (en) | 2018-01-31 | 2026-03-01 | Deciphera Pharmaceuticals Llc | Combination therapy for mastocytosis |
| WO2020185812A1 (en) | 2019-03-11 | 2020-09-17 | Teva Pharmaceuticals International Gmbh | Solid state forms of ripretinib |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| EP4013412B1 (en) | 2019-08-12 | 2026-01-28 | Deciphera Pharmaceuticals, LLC | Ripretinib for treating gastrointestinal stromal tumors |
| EP4084779B1 (en) | 2019-12-30 | 2024-10-09 | Deciphera Pharmaceuticals, LLC | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
| MX2022008103A (es) | 2019-12-30 | 2022-09-19 | Deciphera Pharmaceuticals Llc | Formulaciones de inhibidores de la cinasa amorfa y metodos de estas. |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
| CA1270837A (en) | 1984-12-21 | 1990-06-26 | Hoffmann-La Roche Limited | Oxetanones |
| CA1328881C (en) | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
| CA2035972C (en) | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
| US5274143A (en) | 1991-07-23 | 1993-12-28 | Hoffmann-La Roche Inc. | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
| AUPN163795A0 (en) | 1995-03-10 | 1995-04-06 | DIPNALL, David | A device for extracting energy from moving water particles |
| US6004996A (en) | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
| US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| DE19824175A1 (de) * | 1998-05-29 | 1999-12-02 | Novartis Ag | Amino-azol-Verbindungen |
| TR200100471T2 (tr) | 1998-08-14 | 2001-07-23 | F.Hoffmann-La Roche Ag | Lipaz inhibitörleri içeren farmasötik bileşimler |
| WO2000009123A1 (en) | 1998-08-14 | 2000-02-24 | F. Hoffmann-La Roche Ag | Pharmaceutical compositions containing lipase inhibitors and chitosan |
| US20010039275A1 (en) * | 2000-02-04 | 2001-11-08 | Bowler Andrew Neil | Use of 2,4-diaminothiazole derivatives |
| WO2001064675A1 (en) * | 2000-03-03 | 2001-09-07 | Novartis Ag | Condensed thiazolamines and their use as neuropeptide y5 antagonists |
| HUP0401403A3 (en) * | 2001-08-03 | 2005-11-28 | Novo Nordisk As | 2,4-diaminothiazole derivatives, their use and pharmaceutical compositions containing them |
-
2003
- 2003-02-19 MX MXPA04008379A patent/MXPA04008379A/es active IP Right Grant
- 2003-02-19 BR BR0308108-7A patent/BR0308108A/pt not_active IP Right Cessation
- 2003-02-19 AT AT03742945T patent/ATE373654T1/de not_active IP Right Cessation
- 2003-02-19 EP EP03742945A patent/EP1480976B1/en not_active Expired - Lifetime
- 2003-02-19 AU AU2003210305A patent/AU2003210305B2/en not_active Ceased
- 2003-02-19 WO PCT/EP2003/001667 patent/WO2003072577A1/en not_active Ceased
- 2003-02-19 DE DE60316411T patent/DE60316411T2/de not_active Expired - Fee Related
- 2003-02-19 RU RU2004129285/04A patent/RU2004129285A/ru not_active Application Discontinuation
- 2003-02-19 CA CA002475299A patent/CA2475299A1/en not_active Abandoned
- 2003-02-19 CN CNB03804823XA patent/CN100363362C/zh not_active Expired - Fee Related
- 2003-02-19 KR KR1020047013315A patent/KR100611854B1/ko not_active Expired - Fee Related
- 2003-02-19 JP JP2003571283A patent/JP2005526732A/ja active Pending
- 2003-02-19 PL PL03372463A patent/PL372463A1/xx not_active Application Discontinuation
- 2003-02-19 ES ES03742945T patent/ES2292992T3/es not_active Expired - Lifetime
- 2003-02-25 PE PE2003000182A patent/PE20030930A1/es not_active Application Discontinuation
- 2003-02-25 PA PA20038567301A patent/PA8567301A1/es unknown
- 2003-02-26 TW TW092104045A patent/TW200403995A/zh unknown
- 2003-02-26 AR ARP030100627A patent/AR038704A1/es not_active Application Discontinuation
- 2003-02-26 GT GT200300045A patent/GT200300045A/es unknown
- 2003-02-26 US US10/374,573 patent/US6686381B2/en not_active Expired - Fee Related
- 2003-02-27 UY UY27689A patent/UY27689A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60316411D1 (de) | 2007-10-31 |
| TW200403995A (en) | 2004-03-16 |
| AR038704A1 (es) | 2005-01-26 |
| ATE373654T1 (de) | 2007-10-15 |
| GT200300045A (es) | 2003-09-23 |
| KR20040094735A (ko) | 2004-11-10 |
| RU2004129285A (ru) | 2005-10-27 |
| CA2475299A1 (en) | 2003-09-04 |
| BR0308108A (pt) | 2004-12-07 |
| AU2003210305A1 (en) | 2003-09-09 |
| AU2003210305B2 (en) | 2006-07-06 |
| WO2003072577A1 (en) | 2003-09-04 |
| ES2292992T3 (es) | 2008-03-16 |
| EP1480976A1 (en) | 2004-12-01 |
| PE20030930A1 (es) | 2003-11-08 |
| EP1480976B1 (en) | 2007-09-19 |
| DE60316411T2 (de) | 2008-06-12 |
| MXPA04008379A (es) | 2004-11-26 |
| US6686381B2 (en) | 2004-02-03 |
| UY27689A1 (es) | 2003-08-29 |
| CN1639158A (zh) | 2005-07-13 |
| JP2005526732A (ja) | 2005-09-08 |
| PL372463A1 (en) | 2005-07-25 |
| PA8567301A1 (es) | 2004-02-07 |
| US20030225141A1 (en) | 2003-12-04 |
| CN100363362C (zh) | 2008-01-23 |
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St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20090805 |
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