KR100609672B1 - 액정형 사이클로스포린 - Google Patents

액정형 사이클로스포린 Download PDF

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Publication number
KR100609672B1
KR100609672B1 KR1020007009134A KR20007009134A KR100609672B1 KR 100609672 B1 KR100609672 B1 KR 100609672B1 KR 1020007009134 A KR1020007009134 A KR 1020007009134A KR 20007009134 A KR20007009134 A KR 20007009134A KR 100609672 B1 KR100609672 B1 KR 100609672B1
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KR
South Korea
Prior art keywords
cyclosporin
powder
pharmaceutical composition
solution
drying
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Expired - Fee Related
Application number
KR1020007009134A
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English (en)
Korean (ko)
Other versions
KR20010041094A (ko
Inventor
베넷트데이비드비
카보트커스텐엠
포스터린다씨
레츄가발레스터로스데이비드
패튼존에스
탄트릭시케이
Original Assignee
넥타르 테라퓨틱스
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Publication date
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Publication of KR20010041094A publication Critical patent/KR20010041094A/ko
Application granted granted Critical
Publication of KR100609672B1 publication Critical patent/KR100609672B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020007009134A 1998-02-20 1999-02-11 액정형 사이클로스포린 Expired - Fee Related KR100609672B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7542298P 1998-02-20 1998-02-20
US60/075,422 1998-02-20

Publications (2)

Publication Number Publication Date
KR20010041094A KR20010041094A (ko) 2001-05-15
KR100609672B1 true KR100609672B1 (ko) 2006-08-09

Family

ID=22125639

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007009134A Expired - Fee Related KR100609672B1 (ko) 1998-02-20 1999-02-11 액정형 사이클로스포린

Country Status (10)

Country Link
US (2) US6413547B1 (https=)
EP (1) EP1054685B1 (https=)
JP (1) JP2002503703A (https=)
KR (1) KR100609672B1 (https=)
AT (1) ATE209502T1 (https=)
AU (1) AU755065B2 (https=)
CA (1) CA2321268C (https=)
DE (1) DE69900495T2 (https=)
TW (1) TW581681B (https=)
WO (1) WO1999042124A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020006901A1 (en) 1999-02-05 2002-01-17 Aldo T. Iacono Use of aerosolized cyclosporine for prevention and treatment of pulmonary disease
WO2001087277A2 (en) * 2000-05-15 2001-11-22 Vectura Limited Method of manufacturing particles
WO2003035028A1 (en) * 2001-10-19 2003-05-01 Nektar Therapeutics Modulating charge density to produce improvements in the characteristics of spray-dried proteins
AU2002335046A1 (en) * 2001-10-19 2003-05-06 Inhale Therapeutic Systems, Inc. The use of proton sequestering agents in drug formulations
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US20060039985A1 (en) * 2004-04-27 2006-02-23 Bennett David B Methotrexate compositions
US7151085B2 (en) * 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
US20080227693A1 (en) * 2005-08-29 2008-09-18 Palatin Technologies, Inc. Cyclic Peptide Isolation by Spray Drying
CN1763084B (zh) * 2005-10-11 2010-04-21 山东新时代药业有限公司 高纯度环孢菌素a的制备方法
DE102006051512A1 (de) 2005-12-06 2007-06-14 Pari GmbH Spezialisten für effektive Inhalation Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin
US10245272B2 (en) * 2010-10-25 2019-04-02 Iryna Kravchenko Transmembrane penetration enhancer
ES2666191T3 (es) * 2011-11-15 2018-05-03 Allergan, Inc. Un proceso para la cristalización de la forma 2 de la ciclosporina A
JP7760720B2 (ja) * 2021-11-05 2025-10-27 中国科学院過程工程研究所 シクロペプチドガラス及びシクロペプチドを含有する医薬組成物ガラス

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005913B2 (en) * 1978-05-26 1991-10-30 Imperial Chemical Industries Plc Method of improving the processability of rigid polymers; melts, solutions and shaped articles prepared according to this method
JP2577049B2 (ja) * 1987-06-04 1997-01-29 三共株式会社 シクロスポリン製剤
US5015797A (en) * 1987-11-23 1991-05-14 The Dow Chemical Company Alkylation of polycyclic aromatic compounds to alkylates enriched in the linear- and near linear-substituted isomers
HU203564B (en) 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
US5204329A (en) * 1990-06-11 1993-04-20 Du Pont Merck Pharmaceutical Company Treatment of organ transplantation rejection
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
WO1993000951A1 (en) 1991-07-02 1993-01-21 Inhale, Inc. Method and device for delivering aerosolized medicaments
AU697809B2 (en) * 1993-10-18 1998-10-15 Procter & Gamble Company, The Non-sweating lipsticks
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
JP2936209B2 (ja) * 1994-06-01 1999-08-23 ユーハン コーポレーション サイクロスポリン含有組成物およびその製造方法
US5635159A (en) * 1994-08-26 1997-06-03 Abbott Laboratories Aerosol drug formulations containing polyglycolyzed glycerides
CZ289029B6 (cs) 1994-09-21 2001-10-17 Inhale Therapeutic Systems Způsob aerosolizace práąku, zejména práąkového léku a zařízení k provádění tohoto způsobu
CZ283516B6 (cs) * 1996-09-12 1998-04-15 Galena A.S. Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů
US6077543A (en) * 1996-12-31 2000-06-20 Inhale Therapeutic Systems Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
US5858985A (en) * 1997-10-03 1999-01-12 Markov; Angel K. Treatment of asthma with fructose-1,6-diphosphate

Also Published As

Publication number Publication date
WO1999042124A1 (en) 1999-08-26
DE69900495D1 (de) 2002-01-10
JP2002503703A (ja) 2002-02-05
CA2321268A1 (en) 1999-08-26
ATE209502T1 (de) 2001-12-15
DE69900495T2 (de) 2002-06-27
AU2675099A (en) 1999-09-06
AU755065B2 (en) 2002-12-05
EP1054685A1 (en) 2000-11-29
TW581681B (en) 2004-04-01
CA2321268C (en) 2010-04-13
EP1054685B1 (en) 2001-11-28
KR20010041094A (ko) 2001-05-15
US6413547B1 (en) 2002-07-02
US20030130176A1 (en) 2003-07-10

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