KR100607026B1 - Solid cosmetic composition containing urea - Google Patents

Abstract

The present invention relates to a water-in-oil type composition containing a large amount of urea, which is excellent in anti-inflammatory effect, and is easy to carry and easy to use.

Description

Solid cosmetic composition containing urea "             

The present invention relates to a water-in-oil type composition containing a large amount of urea, a solid ultraviolet ray cosmetic composition which is excellent in anti-inflammatory effect and is easy to carry and easy to use.

Urea, which is a commonly used raw material in cosmetics, has been used in many functional cosmetic formulations because it has functions of skin moisturizing, anti-inflammation and keratinization depending on the content of use. In addition, this substance is distributed in each organ and body fluids of the human body, and it is known that it is not toxic to the human body, so that it is attracting attention in pharmaceuticals. However, the fact that urea reacts with water during formulation in cosmetics to cause degradation and that the degradation products not only raise the pH in the product but also release ammonia gas has limited the application of urea. Thus, in order to solve this problem, US Pat. No. 5,527,961 discloses that the formulation is acidified by using a small amount of acid to complete the formulation, but this has only a temporary effect, and after a certain period of time, it does not prevent the urea decomposition reaction. Also in U.S. Patent No. 4672078, lactones were used to prevent the degradation of urea, but application was limited to cosmetic formulations with commonly used fluidity.

Currently, the solid cosmetic composition is classified into various kinds according to the purpose of use, but it is mainly composed of a solid material such as a foundation using a puff by pressing a powder or a pigment, a formulation such as a two-way cake and a solidifying oil, Lipstick, and the like, and these formulations have been favorably used by consumers due to their ease of use and portability. Due to these advantages, researches in the field of solid dosage form have been actively conducted recently, and there is a tendency to change into a solidified formulation even in an emulsified form. However, although most of the products that have already been released are in the form of emulsions, there is no difference between the feeling of use of the existing formulations and the feeling of use of the existing formulations. In order to compensate for these disadvantages, volatile silicone Although oil was used, the choice of powders and pigments to be used was limited, and the stability of the powders varied sharply. In order to solve this problem, US Pat. No. 5645903A discloses a patent for a solid cosmetic composition which is solidified using agar and gelatin. However, due to the disadvantages of separation during formulation and compatibility with the container, And the contents are separated from the container. U.S. Patent No. 5362482A discloses a water-in-oil type solid cosmetic composition. Although there is no compatibility problem with the container, there is a problem that the usability which is a disadvantage of the water-in-oil type is inferior and a satisfactory result is not obtained from the product stability.

As described above, various attempts have been made to apply urea to cosmetics, but no satisfactory results have been obtained.

The present inventors have conducted intensive studies to solve the conventional problems. As a result, they have found that when urea is used together with an oil gelling agent having a high melting point and 10 to 40% by weight of a powder for solidifying a formulation, It is possible to obtain a solid cosmetic composition having a relatively low amount and an excellent stability compared with a conventional formulation having fluidity, and thus the present invention has been completed. The cosmetic composition thus developed exhibits a soothing effect on skin damaged by ultraviolet rays as well as ultraviolet rays.

The present invention relates to a composition comprising 15 to 40% by weight of an oil, 6 to 15% by weight of an oil gelling agent, and a surfactant of a silicone surfactant and a HLB 8 or less (mixing weight ratio 2: 1 to 5: 10 to 40% by weight of ultraviolet screening powder, 5 to 20% by weight of a moisturizer, 5 to 20% by weight of urea, 0.25 to 10% by weight of lactone to prevent decomposition of urea, and And 5 to 40% by weight of water.

In the present invention, when the urea content is less than 5% by weight, the anti-inflammatory effect is not exerted properly. When the urea content is more than 20% by weight, the amount of urea is excessively used compared to the desired anti-inflammatory effect. When the content of the lactone is less than 0.25% by weight, the urea decomposition can not be effectively prevented. When the content of the lactone is more than 10% by weight, the amount of the lactone to be used is excessively large. In addition, if the content of the oil which affects the hardness of the product is less than 15% by weight, the product becomes too hard, and if it exceeds 40% by weight,

The solid cosmetic composition of the present invention is a solid cosmetic composition comprising an ester oil obtained by condensing an alcohol having 3 to 16 carbon atoms and a fatty acid having 4 to 20 carbon atoms as an oil, a fat obtained by condensing glycerol with a fatty acid having 8 to 20 carbon atoms, a liquid paraffin, And a silicone oil is essentially used as the lubricant.

The silicone oil used in the present invention is represented by the following formula (1) or (2) as a volatile oil:

In this formula,

j represents an integer of 0 to 3,

i represents an integer of 1 to 6;

The oil gelling agent used in the present invention is solid wax and metallic soap. Examples of the solid wax include a linear or branched hydrocarbon wax having a melting point of 50 ° C or higher, such as paraffin wax having 25 to 52 carbon atoms, microcrystalline wax, ozokerite, sericin, ester wax such as canna wax, Wax is included. Metallic soaps include calcium stearate, calcium palmitate, lithium 2-ethylhexanoate and zinc stearate. These may be used in one or more species.

In the present invention, the ratio of the oil to the oil gelling agent varies depending on the extent of the product, but 20: 1 to 3: 1 is suitable.

As the silicone surfactant in the present invention, the following compounds of formula (3) or (4) are used:

In this formula,

p represents 7 to 17,

q represents 1 to 100,

m represents 1 to 40,

n represents 0 to 200,

PE is - (C ₂ H ₄ O) _a (C ₃ H ₆ O) _b -H having a molecular weight of 250 to 2000, wherein a / b is 100/0 to 20/80,

d represents 50 to 70,

e represents 2 to 5,

f represents 8 to 12;

In the present invention, surfactants having an HLB of 8 or less include sorbitan monoisostearate, sorbitan monooleate, sorbitan diolate, sorbitan sesquioleate, sorbitan sesquiisostearate, glycerol monoisostearate, glycerol Diisostearate, glycerol monooleate, glycerol diolate, glyceryl sebacate, and the like.

The ultraviolet screening agent used in the present invention refers to those commonly used in cosmetics. The powder for ultraviolet screening refers to titanium dioxide and zinc oxide coated with silicone. The ultraviolet screening powder refers to 60 to 100% by weight of ultraviolet screening agent, Ultraviolet powder is occupied.

As the moisturizing agent, polyols such as glycerin, 1,3-butylene glycol, propylene glycol, sorbitol and the like which are conventionally used in cosmetics are used.

The composition of the present invention can be formulated as a lipstick that is made by pressing a pigment and using a puff or a two-way cake and a solidifying oil to apply directly to the skin.

Hereinafter, the present invention will be described in detail through comparative examples and examples. However, these examples are provided only for understanding of the present invention, and the scope of the present invention is not limited to these examples in any sense.

Examples 1 to 3 and Comparative Examples 1 to 6

The oil phase portion and the water phase portion shown in Tables 1 and 2 were heated and dissolved at 78 to 80 DEG C, respectively, and the ultraviolet screening agent and the ultraviolet screening agent powder were dispersed in the heated oil phase. Using the ROBO MIC of TOKUSHU KIKA, After stirring for a minute, the aqueous phase was gradually added, and the mixture was emulsified at 5000 rpm for 4 to 5 minutes using the same method. The mixture was then distributed to a vessel and cooled to room temperature to prepare Examples 1 to 3 and Comparative Examples 1 to 6. The completion of the water-in-oil type was determined by measuring the electrical conductivity or when the product was difficult to apply, the product was spread on the skin and examined for washability against water to confirm the completed formulation. In Tables 1 and 2, the unit is wt%.

Raw material name Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Paid  DOW CORNONG 245 Caprylic / Capric Triglyceride Ceresin Zinc Stearate Silicone Surfactant HLB 8 or less Surfactant 15.0 8.0 8.0 1.0 1.0 2.0 15.0 8.0 8.0 1.0 1.0 2.0 15.0 8.0 8.0 1.0 1.0 2.0 15.0 8.0 8.0 1.0 1.0 2.0 15.0 8.0 8.0 1.0 1.0 2.0 Sunscreen  Octylmethoxycinnamate ZnO 3.0 20.0 3.0 20.0 3.0 20.0 3.0 20.0 3.0 20.0 Awards  Glycerin Propylene glycol Magnesium sulfate Lactone Urea Preservative Water 2.0 3.0 0.3 0.25 5.0 0.3 Remainder 2.0 3.0 0.3 0.7 10.0 0.3 Remainder 2.0 3.0 0.3 1.5 15.0 0.3 Remainder 2.0 3.0 0.3 - - 0.3 balance 2.0 3.0 0.3 - 10.0 0.3 Remainder

Raw material name Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Paid  Decamethylcyclopentasiloxane Cetylisooctanoate Ceresin Hardened castor oil Liquid Paraffin Silicone Surfactant HLB 8 or less Surfactant 20.0 18.0 10.0 - - 2.0 - 20.0 18.0 10.0 - - - 2.0 38.0 - - 10.0 - - 2.0 - - - - 38.0 - 2.0 Powder TIO _{2 without} talc silicone coating ZNO without silicone coating 20.0 - - 20.0 - - - 10.0 - - - 10.0 Awards  water Balance Balance Balance Balance

Anti-inflammatory experiment

Female 5 hairless mice were used for each group, and the left ear was used as a control site and the right ear was used as a test site. Each mouse's ear was washed with ethanol and the sample was applied to the right ear in an amount of 20 / / ear once a day for 4 days. After 1 hour of the last application, arachidonic acid (2 ㎎ / ear: ethanol in the solvent) One hour later, the thickness of both ears was measured three times with a micro-caliper to measure the anti-inflammatory effect.

sample Thickness of mouse ear (탆) Before processing After processing % Inhibition Control group 299 547 - Example 1 287 512 9.27 Example 2 289 497 16.1 Example 3 292 465 29.4 Comparative Example 1 296 530 5.6

Determination of anti-inflammatory effect (%) = (A-B) / A × 100

A: average swelling value of control ears (ear thickness after treatment with arachidonic acid-thickness of ear before treatment)

B: Average swelling value of the ear of the sample application group (ear thickness after treatment with arachidonic acid - ear thickness before treatment)

As shown in Table 3, Examples 1 to 3 in which urea was added showed excellent anti-inflammatory effect as compared with Comparative Example 1 in which urea was not contained.

Measurement of decomposition degree of urea

The resulting water-in-oil type emulsion is put in water to boil the emulsion completely and completely destroyed. After allowing to stand for one day, the aqueous solution is filtered and the pH is measured using a PH meter.

PH immediately after preparation After 10 days (at 50 ° C in a constant temperature bath) pH After 20 days (50 캜 constant temperature bath) pH After 30 days (at 50 ° C in a constant temperature bath) pH After 40 days (at 50 ° C in a constant temperature bath) pH Example 1 6.4 6.6 6.9 6.9 7.0 Example 2 6.2 6.5 6.6 6.5 6.6 Example 3 6.5 6.6 6.5 6.7 6.4 Comparative Example 1 6.4 6.7 7.2 7.7 8.5

From the above results, Examples 1 to 3 contain lactones to inhibit the decomposition of urea to maintain the pH in the constant water. In Comparative Example 2, which did not contain lactone, the urea decomposition accelerated and the pH of the aqueous solution was increased.

Stability evaluation

The sample to be investigated is left at 25 ° C and 50 ° C, respectively, and it is observed whether or not it is separated.

Storage temperature Days to keep Example Comparative Example One 2 3 3 4 5 6 25 ℃ After 10 days ⊙ ⊙ ⊙ △ × △ × After one month ⊙ ⊙ ⊙ × × × × 50 ℃ After 10 days ⊙ ⊙ ⊙ × × × × After one month ⊙ ⊙ ⊙ × × × ×

* Evaluation: ⊙ stable

              △ Unstable

              × separation

As shown in Table 5, it can be seen that the embodiment is stable at room temperature (25 占 폚) and 50 占 폚, as compared with the comparative example.

The cosmetic composition according to the present invention is excellent in anti-inflammatory effect by containing a large amount of urea, and is in the form of a water-in-oil solid, which is easy to carry and easy to use.

Claims (4)

From 1 to 10 weight percent (based on the total weight of the composition) of a mixture of 15 to 40 weight percent oil, 6 to 15 weight percent oil gelling agent, and less than 8 weight percent silicone surfactant and less than HLB 8 surfactant (mixing weight ratio 2: 1 to 5: 10 to 40% by weight of ultraviolet light shielding powder, 5 to 20% by weight of a moisturizer, 5 to 20% by weight of urea, 0.25 to 10% by weight of lactone and 5 to 40% by weight of water. The oil according to claim 1, wherein the oil essentially contains a silicone oil of the following formula (1) or (2), an ester oil obtained by condensing an alcohol having 3 to 16 carbon atoms with a fatty acid having 4 to 20 carbon atoms, A liquid obtained by condensing a liquid paraffin, a paraffin, an isoparaffin and a squalane; Formula 1

(2)

In this formula, j represents an integer of 0 to 3, i represents an integer of 1 to 6; The method according to claim 1, wherein the oil gelling agent is selected from the group consisting of paraffin wax having a melting point of 50 ° C or higher and 25 to 52 carbon atoms, microcrystalline wax, ozokerite, sericin, carnauba wax, candelina wax, calcium stearate, calcium palmitate, - ethylhexanoate and zinc stearate. ≪ / RTI > The cosmetic composition according to claim 1, wherein the silicone surfactant is a compound represented by the following formula (3) or (4): (3)

Formula 4

In this formula, p represents 7 to 17, q represents 1 to 100, m represents 1 to 40, n represents 0 to 200, PE is - (C ₂ H ₄ O) _a (C ₃ H ₆ O) _b -H having a molecular weight of 250 to 2000, wherein a / b is 100/0 to 20/80, d represents 50 to 70, e represents 2 to 5, f represents 8 to 12;