JP2003104832A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation for skin cosmetic having high ultraviolet shielding effects and preventing of skin roughening by ultraviolet rays. SOLUTION: This skin care preparation comprises at least one kind of an ultraviolet light absorber and/or an ultraviolet light scattering agent and one or more kinds selected from borage oil, preferably further β-glucan, carboxymethylated glucan, a Glycyrrhizae Radix flavonoid and Phellodendri Cortex extract.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a skin external preparation,
More specifically, the present invention provides an external preparation for the skin which is excellent in the effect of preventing rough skin due to ultraviolet rays.

[0002]

2. Description of the Related Art Skin is exposed to ultraviolet rays to cause a sunburn phenomenon and the skin is blackened. These usually return to the original skin color after a lapse of days, but repeated irradiation of ultraviolet rays causes rough skin, stains and freckles, and when worse, skin cancer may develop. In recent years, such problems have been particularly noticed, and many cosmetics that protect the skin from ultraviolet rays have been marketed. These products contain a substance that absorbs ultraviolet rays and a substance that scatters ultraviolet rays, and a device for blocking ultraviolet rays on the skin surface has been devised, and these techniques have been developed.

[0003]

However, it is difficult to completely block ultraviolet rays even when an external skin preparation containing an ultraviolet absorber or an ultraviolet scatterer is used.
When the external skin application on the skin surface becomes uneven due to sweating or physical contact, the UV blocking effect is reduced,
It may cause rough skin.

[0004]

In view of the above circumstances, the inventors of the present invention have conducted extensive studies in order to obtain an external preparation for skin which has a high UV blocking effect and is excellent in the effect of preventing rough skin due to UV rays. It has been found that the above problem can be solved by using an ultraviolet absorber and / or an ultraviolet scatterer in combination with borage oil, and the present invention has been completed. That is, the present invention is a skin external preparation characterized by containing at least one of an ultraviolet absorber and / or an ultraviolet scatterer and borage oil.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The constitution of the present invention will be described in detail below. As the ultraviolet absorber used in the present invention, para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester,
N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA
Benzoic acid type UV absorbers such as ethyl ester, N, N-dimethyl PABA butyl ester, anthranilate type UV absorbers such as homomenthyl-N-acetylanthranilate, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, Salicylic acid type UV absorbers such as phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate,
Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-
Diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate,
Isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α- Cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate and other cinnamic acid-based UV absorbers, 2,4-dihydroxy Benzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxy Benzophenone, 2-
Hydroxy-4-methoxy-4'-methylbenzophenone, 2-
Hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-
Benzophenone-based UV absorbers such as phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, 3- (4'-methylbenzylidene) -d, 1 -Camphor, 3-benzylidene-d, 1-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2- (2 '-Hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy
-5'-methylphenylbenzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one Etc. Moreover, examples of the ultraviolet scattering agent used in the present invention include titanium oxide, zinc oxide, selenium oxide, and kaolin.

The amount of the ultraviolet absorber or the ultraviolet scatterer used in the present invention is 0.01 to 3 in the total amount of the external preparation for skin.
It is 0% by mass, preferably 0.1 to 20% by mass.
If it is less than 0.01% by mass, the effect is not exhibited, and if it exceeds 30% by mass, it is not preferable for the product.

The borage oil used in the present invention is an oil extracted from borage grass and contains γ-linolenic acid. At the time of use, it may be concentrated to increase the γ-linolenic acid content, or oils and fats prepared from these and other components may be used. As a commercially available product, one manufactured by Nippon Synthetic Chemical Industry Co., Ltd. is available.

The blending amount of borage oil in cosmetics is
Usually 0.1 to 30.0 mass%, preferably 0.5 to 1
It is 0.0 mass%. If the compounding amount is less than 0.1% by mass, the effect is not sufficient, and if the compounding amount exceeds 30.0% by mass, the stability with time is insufficient.

Further, it is preferable to blend one or more selected from β-glucan, carboxymethylated glucan, licorice flavonoid, and psyllium extract.

In addition to the above essential constituents, the external preparation for skin of the present invention may contain, if necessary, conventional pharmaceutical products, quasi drugs,
Other ingredients used in external preparations for skin such as cosmetics, for example, liquid paraffin, petrolatum, microcrystalline wax, squalane, almond oil, olive oil, hydrogenated oil, castor oil, owl, coconut oil, beeswax, lanolin, carnauba wax, palm oil. Oils such as lanolinic acid, myristic acid, palmitic acid, stearic acid, isostearic acid, fatty acids such as oleic acid, lauryl alcohol,
Cetanol, stearyl alcohol, oleyl alcohol, higher alcohols such as cholesterol, isopropyl myristate, myristyl myristate, esters such as isopropyl palmitate, acids such as citric acid, tartaric acid, lactic acid, sodium hydroxide, potassium hydroxide, triethanol Alkaline such as amine, lauryl dimethylamino acetic acid betaine, glyceryl monostearate, sorbitan fatty acid ester, polyoxyethylene fatty acid ester,
Surfactants such as polyoxyethylene alkyl ether,
Glycerin, propylene glycol, 1,3-butylene glycol, dipropylene glycol, sorbitol,
Moisturizers such as sodium pyrrolidonecarboxylate, polyethylene glycol, hyaluronic acid, powders such as talc and calcium carbonate, antiseptic disinfectants such as paraben and phenoxyethanol, thickeners such as carboxymethyl cellulose, sodium alginate, carboxyvinyl polymer, iron yellow oxide , Titanium yellow, colorants such as cursamine, photosensitizer, ceramides such as ceramide 1, ceramide 2, ceramide 3 and ceramide 6, carrot, comfrey, aloe, mallow, linden, iris, grape, yochinin, melissa, yarrow, Extracts such as button, loofah, lily, peony, assembly, clove, birch, loquat, etc., vitamins such as tocopherol nicotinate, retinol palmitate, etc. can be added. Of course, these components must be used within a qualitative and quantitative range that does not impair the effects of the present invention.

The dosage form of the external preparation for skin of the present invention is arbitrary,
Solution system, solubilization system, emulsion system, powder dispersion system, water-two-layer system,
Any formulation such as water-oil-powder three-layer system may be used.
In addition, the application of the external preparation for skin of the present invention is also optional, such as lotion, emulsion, cream, facial cosmetics such as packs,
It can be used for makeup cosmetics such as foundations, lipsticks and eye shadows, body cosmetics, aromatic cosmetics and the like.

[0012]

EXAMPLES The present invention will be specifically described with reference to Examples. The present invention is not limited to this. The blending amount is% by mass. Regarding the degree of rough skin, the samples are cumulatively applied, and the skin conditions immediately before the start of the test and after one month has passed are compared with those obtained by taking a replica of the skin using a replica method using myristin resin and observing with a microscope. I went by.

[Rough skin test by ultraviolet rays] In summer (July-August), one group of 10 subjects, which are often exposed to ultraviolet rays, was set as 10 subjects, and one kind of sample cream was applied to the face every day for one month in the morning, It was performed by comparing the degree of rough skin at the first month with that immediately before the start of the test. The judgment criteria are shown in Table 1, and the study prescriptions are shown in Table 2. The formulations in Table 2 were manufactured by a conventional method. Table 3 shows the results of the rough skin test by cumulative application.

[0014]

[Table 1]

[0015]

[Table 2]

[0016]

[Table 3]

From the results, it was carried out based on Example 1 as compared with Comparative Example 1, Comparative Example 2 and Comparative Example 3 in which the borage oil was replaced by another oil agent, and Comparative Example 4 in which the ultraviolet absorber was not mixed. It can be seen that Example 1 is superior in the effect of preventing rough skin due to ultraviolet irradiation. Further, it can be seen that other ultraviolet absorbers and ultraviolet scatterers have the same effects as in Example 1.

Further, Table 4 shows examples of the present invention.

[0019]

[Table 4]

Example 9 Lotion A lotion was manufactured by a conventional method according to the following formulation. Ethanol 5.0 Polyoxyethylene (20 mol) oleyl ether 0.3 Borage oil 0.1 Methyl paraoxybenzoate 0.1 Fragrance suitable amount 1,3-butylene glycol 5.0 Glycerin 5.0 Hydroxymethoxybenzophenone sodium sulfonate 0.1 Lactic acid 0.2 Sodium metaphosphate 0.05 Coloring agent Purified water Remaining amount

Example 10 Emulsion An emulsion was produced by a conventional method according to the following formulation. Cetanol 0.8 Cetostearyl alcohol 1.4 Liquid paraffin 2.0 Borage oil 1.0 Stearyl glycyrrhetinate 0.1 Octyl methoxycinnamate 0.5 Sorbitan monostearate 0.5 Self-emulsifying glyceryl monostearate 1.0 Polyoxypropylene stearyl ether 0.5 Stearic acid 0.5 Ethyl paraoxybenzoate 0.2 Xylobiose 1.0 Glycerin 3.0 Sodium hyaluronate 0.1 Nicotinic acid amide 0.1 Potassium hydroxide 0.15 EDTA-2Na 0.1 Fragrance suitable amount Purified water Remaining amount

Example 11 Cream A cream was produced by a conventional method according to the following formulation. Squalane 5.0 Borage oil 3.0 Stearic acid 3.0 Stearyl alcohol 3.0 Self-emulsifying glyceryl monostearate 6.0 White beeswax 3.0 Hydroxymethoxybenzophenone 1.0 Ethyl paraoxybenzoate 0.2 Xylobiose 1.0 Propylene glycol 5.0 Glycerin 5.0 Triethanolamine 1.0 Button extract 0.005 Purified water Remaining amount

Example 12 Sun Care Suncare was manufactured by a conventional method according to the following formulation. Octyl methoxycinnamate 5.0 Tetrahydroxybenzophenone 2.0 Stearic acid 4.0 Cetanol 1.0 Isocetyl stearate 1.0 Isodecyl pivalate 3.0 Borage oil 2.0 Ergocalciferol 0.1 Ethyl paraoxybenzoate 0.2 Fragrance suitable amount Glycerin 5.0 Sodium hyaluronate 0.05 Triethanolamine 0.1 Purified water Remaining amount

Example 13 Foundation A foundation was produced by a conventional method according to the following formulation. Liquid paraffin 5.0 Myristyl myristate 2.0 Polyisobutene 2.0 Oleyl alcohol 2.0 Stearyl alcohol 2.0 Polyoxyethylene sorbitan oleate 0.5 Octyl methoxycinnamate 3.0 Butyl paraoxybenzoate 0.1 Fragrance Talc 5.0 Titanium oxide 5.0 Iron oxide 4.0 Magnesium aluminum silicate 0.75 Trehalose 0.5 Potassium hydroxide 0.05 Xanthan gum 0.15 Glycerin 4.0 Citric acid 0.3 Purified water Remaining amount The external preparations for skin of Examples 9 to 13 were excellent in the effect of preventing rough skin due to ultraviolet rays.

[0025]

The external preparation for skin of the present invention has a high ultraviolet blocking effect and is excellent in preventing rough skin caused by ultraviolet rays.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/021 A61K 7/021 7/42 7/42 31/202 31/202 31/352 31/352 31 / 716 31/716 35/78 35/78 JK X A61P 17/16 A61P 17/16 43/00 121 43/00 121 F Term (reference) 4C083 AA082 AA111 AA112 AA121 AA122 AB032 AB222 AB232 AB242 AB432 AC022 AC072 AC102 AC122 AC182 AC212 AC242 AC302 AC342 AC352 AC422 AC442 AC482 AC792 AC841 AC902 AD022 AD212 AD311 AD332 AD352 AD532 AD632 AD652 BB46 CC02 CC04 CC05 CC12 CC19 DD23 DD31 EE12 EE13 EE17 4C086 AA01 AA02 BA08 EA20 ZA25 MA17 MA02 MA60 NA14 MA0 MA14 MA07 MA14 MA07 MA14 MA07 MA14 MA07 MA14 AC11 BA08 BA32 CA03 MA02 MA63 NA05 NA14 ZA89 ZC75 4C206 AA01 AA02 DA04 MA02 MA03 MA04 MA11 MA13 MA28 MA83 NA05 NA14 ZA89

Claims (2)

[Claims] 1. A skin external preparation containing at least one of an ultraviolet absorber and / or an ultraviolet scatterer and a borage oil. 2. A skin external preparation characterized by further comprising one or more selected from β-glucan, carboxymethylated glucan, licorice flavonoid, and psyllium extract in addition to the skin external preparation of claim 1.