KR100580622B1 - 비침습적 혈액성분 측정방법 및 장치 - Google Patents
비침습적 혈액성분 측정방법 및 장치 Download PDFInfo
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- KR100580622B1 KR100580622B1 KR20030017137A KR20030017137A KR100580622B1 KR 100580622 B1 KR100580622 B1 KR 100580622B1 KR 20030017137 A KR20030017137 A KR 20030017137A KR 20030017137 A KR20030017137 A KR 20030017137A KR 100580622 B1 KR100580622 B1 KR 100580622B1
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Abstract
Description
Claims (21)
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- (a) 피검체의 특정부위에 대한 과도압력에 해당하는 초기두께를 결정하는 단계;(b) 상기 피검체의 특정부위에 상기 과도압력 이하의 압력을 인가하여 상기 특정부위의 두께를 제1 두께와 제2 두께로 가변시키고, 상기 제1 두께와 상기 제2 두께에서 각각 측정된 제1 및 제2 흡수 스펙트럼간의 차이 흡수 스펙트럼을 구하는 단계;(c) 상기 (b) 단계를 실측된 특정 혈액성분에 대한 K개의 서로 다른 농도에 대하여 반복 수행하여 얻어지는 K개의 차이 흡수 스펙트럼과 상기 실측된 특정 혈액성분의 농도 쌍을 이용하여 상기 혈액성분의 농도에 대한 통계모델을 구하는 단계; 및(d) 상기 특정부위에서 상기 제1 두께와 상기 제2 두께에서 각각 측정된 제1 및 제2 흡수 스펙트럼간의 차이 흡수 스펙트럼으로부터 상기 혈액성분의 농도를 상기 통계모델을 이용하여 예측하는 단계를 포함하는 비침습적 혈액성분 측정방법을 실행하기 위한 프로그램을 기재된 컴퓨터를 읽을 수 있는 기록매체.
- 빛을 발생시키는 광원부;상기 광원부에서 발생된 빛의 파장을 분광하는 분광부;특정 개인의 측정하고자 특정부위가 삽입되며, 상기 분광부에서 분광된 빛을 상기 특정부위로 전달하여 조사한 다음 상기 특정부위를 투과한 광을 모으고, 상기 특정부위에 인가되는 압력에 따라서 특정부위의 두께를 조절하고 상기 특정부위를 고정시키는 인체기기 인터페이스부;상기 인체기기 인터페이스부에 고정된 특정부위로부터 투과되는 각 두께에서의 흡수 스펙트럼을 검출하는 검출부; 및상기 특정부위에 대한 과도압력에 해당하는 초기두께를 결정하고, 상기 인체기기 인터페이스부에 상기 과도압력 이하의 압력을 인가하여 상기 특정부위의 두께를 가변시키고, 상기 검출부에서 검출되는 가변된 각 두께에서 측정된 흡수 스펙트럼들간의 차이 흡수 스펙트럼과 실측된 특정 혈액성분의 농도를 이용하여 구해진 상기 혈액성분에 대한 통계모델을 이용하여, 상기 특정 부위에서 측정된 차이 흡수 스펙트럼으로부터 해당 혈액성분의 농도를 예측하는 신호처리부를 포함하는 것을 특징으로 하는 비침습적 혈액성분 측정장치.
- 제12 항에 있어서, 상기 신호처리부는 실측된 상기 혈액성분에 대한 농도에 대응하여, 상기 과도압력에 해당하는 두께보다 두껍게 하여 상기 특정 부위를 제1 두께 및 제2 두께로 조정하고, 제1 및 제2 두께에서 상기 특정 부위로부터 측정된 제1 및 제2 흡수 스펙트럼과의 차이 흡수 스펙트럼을 획득하고, K개의 차이 흡수 스펙트럼과 상기 실측된 농도 쌍에 대하여 다변량 통계분석을 수행하여 상기 혈액성분의 농도에 대한 통계모델을 수립하는 것을 특징으로 하는 비침습적 혈액성분 측정장치.
- 제13 항에 있어서, 상기 신호처리부는 두께를 변화시켜 상기 특정 부위를 제1 두께 및 제2 두께로 조정하고, 상기 제1 및 상기 제2 두께에서 상기 특정 부위로부터 측정된 제1 및 제2 흡수 스펙트럼과의 차이 흡수 스펙트럼을 획득하고, 상기 통계모델을 이용하여 상기 혈액성분의 농도를 예측하는 것을 특징으로 하는 비침습적 혈액성분 측정장치.
- 제14 항에 있어서, 상기 초기두께와 상기 제1 두께 사이의 증가폭은 0.2 mm 이내인 것을 특징으로 하는 비침습적 혈액성분 측정장치.
- 제15 항에 있어서, 상기 제1 두께와 제2 두께 사이의 증가폭은 0.1 내지 0.3 mm 인 것을 특징으로 하는 비침습적 혈액성분 측정장치.
- 제13 항에 있어서, 상기 신호처리부는 실측된 상기 혈액성분에 대한 농도에 대응하여, 상기 과도압력 해당 두께보다 두께를 증가시켜 상기 특정 부위를 제1 두께로 조정하여 일정한 시간동안 유지한 후, 두께를 증가시켜 상기 특정 부위를 제2 두께 및 제3 두께로 조정하고, 제2 및 제3 두께에서 상기 특정 부위로부터 측정된 제1 및 제2 흡수 스펙트럼과의 차이 흡수 스펙트럼을 획득하고, K개의 차이 흡수 스펙트럼과 상기 실측된 농도 쌍에 대하여 다변량 통계분석을 수행하여 상기 혈액성분의 농도에 대한 통계모델을 수립하는 것을 특징으로 하는 비침습적 혈액성분 측정장치.
- 제17 항에 있어서, 상기 신호처리부는 두께를 변화시켜 제2 및 제3 두께에서 상기 특정 부위로부터 측정된 제1 및 제2 흡수 스펙트럼과의 차이 흡수 스펙트럼을 획득하고, 상기 통계모델을 이용하여 상기 혈액성분의 농도를 예측하는 것을 특징으로 하는 비침습적 혈액성분 측정장치.
- 제17 항 또는 제18 항에 있어서, 상기 제1 두께와 제2 두께 사이의 증가폭은 0.05 내지 0.2 mm 인 것을 특징으로 하는 비침습적 혈액성분 측정장치.
- 제19 항에 있어서, 상기 제2 두께와 제3 두께 사이의 증가폭은 0.1 내지 0.3 mm 인 것을 특징으로 하는 비침습적 혈액성분 측정장치.
- (a) 피검체의 특정부위에 대한 과도압력에 해당하는 초기두께를 결정하는 단계;(b) 상기 피검체에 상기 과도압력 이하의 압력을 인가하여 상기 특정부위의 두께를 제1 두께로 가변시킨 후 일정한 시간동안 유지한 후, 제2 두께 및 제3 두께로 가변시키고, 상기 제2 두께와 상기 제3 두께에서 각각 측정된 제1 및 제2 흡수 스펙트럼의 차이 흡수 스펙트럼을 구하는 단계;(c) 상기 (b) 단계를 실측된 특정 혈액성분에 대한 K개의 서로 다른 농도에 대하여 반복 수행하여 얻어지는 상기 K개의 차이 흡수 스펙트럼과 상기 실측된 특정 혈액성분의 농도 쌍을 이용하여 상기 혈액성분의 농도에 대한 통계모델을 수립하는 단계; 및(d) 상기 특정 부위에서 상기 제1 두께로 가변시킨 후 일정한 시간동안 유지한 후, 상기 제2 두께 및 상기 제3 두께로 가변시키고, 상기 제2 두께와 상기 제3 두께에서 각각 측정된 제1 및 제2 흡수 스펙트럼의 차이 흡수 스펙트럼으로부터 상기 혈액성분의 농도를 상기 통계모델을 이용하여 예측하는 단계를 포함비침습적 혈액성분 측정방법을 실행하기 위한 프로그램을 기재된 컴퓨터를 읽을 수 있는 기록매체.
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JP2004079140A JP2004283585A (ja) | 2003-03-19 | 2004-03-18 | 非侵襲的血液成分濃度の測定方法及び装置 |
US10/802,920 US7248911B2 (en) | 2003-03-19 | 2004-03-18 | Method and apparatus for noninvasively measuring a concentration of a blood component |
CNB2004100640004A CN1313051C (zh) | 2003-03-19 | 2004-03-19 | 无创测量血液成分浓度的方法和装置 |
EP20060075413 EP1665980A1 (en) | 2003-03-19 | 2004-03-19 | Method and apparatus for noninvasively measuring a concentration of a blood component |
EP20040251608 EP1459679B1 (en) | 2003-03-19 | 2004-03-19 | Apparatus for noninvasively measuring a concentration of a blood component |
DE200460001075 DE602004001075T2 (de) | 2003-03-19 | 2004-03-19 | Gerät zur nichtinvasiven Konzentrationsmessung einer Blutkomponente |
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EP (2) | EP1459679B1 (ko) |
JP (1) | JP2004283585A (ko) |
KR (1) | KR100580622B1 (ko) |
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EP1596716B1 (en) * | 2003-01-24 | 2014-04-30 | The General Hospital Corporation | System and method for identifying tissue using low-coherence interferometry |
KR100624412B1 (ko) * | 2003-09-16 | 2006-09-18 | 삼성전자주식회사 | 혈중성분 측정장치 및 이를 이용한 혈중성분측정방법 |
JP5049510B2 (ja) * | 2006-05-08 | 2012-10-17 | 東芝メディカルシステムズ株式会社 | 非侵襲的測定装置 |
EP1955653B1 (en) * | 2005-11-30 | 2010-12-22 | Toshiba Medical Systems Corporation | Method of noninvasively measuring glucose |
GB0611289D0 (en) * | 2006-06-08 | 2006-07-19 | Univ St Andrews | Raman spectroscopy |
US8611975B2 (en) * | 2009-10-28 | 2013-12-17 | Gluco Vista, Inc. | Apparatus and method for non-invasive measurement of a substance within a body |
KR101306340B1 (ko) * | 2009-01-08 | 2013-09-06 | 삼성전자주식회사 | 생화학 시료에 포함된 성분의 농도 측정 방법 및 이를 이용한 검사 결과의 신뢰도 추정 방법 |
WO2010138385A1 (en) * | 2009-05-27 | 2010-12-02 | Analog Devices, Inc. | Multiuse optical sensor |
RU2449260C1 (ru) * | 2011-02-02 | 2012-04-27 | Олег Леонидович Головков | Способ спектрального анализа и определения концентраций компонент мутного вещества и устройство для его осуществления (варианты) |
DE102012018357A1 (de) | 2012-09-17 | 2014-03-20 | Liebherr-Hausgeräte Ochsenhausen GmbH | Kühl- und/oder Gefriergerät |
KR101666106B1 (ko) | 2014-03-13 | 2016-10-14 | 울산대학교 산학협력단 | 체액 분포 모니터링 방법 및 장치 및 혈장량 측정 방법 및 장치 |
JP2015181908A (ja) * | 2014-03-26 | 2015-10-22 | 京セラ株式会社 | 測定装置、測定システム、測定方法、及び測定装置を備える電子機器 |
CN105249974A (zh) * | 2015-10-15 | 2016-01-20 | 华南师范大学 | 一种基于压力调制光谱技术的无创葡萄糖检测系统与方法 |
CN106137218B (zh) * | 2016-07-30 | 2019-03-19 | 哈尔滨工业大学 | 一种非侵入红外复合吸收精测血糖变化的方法 |
CN108261202B (zh) * | 2016-12-30 | 2021-09-10 | 北京大学 | 一种测量血糖的系统及其使用方法 |
CN107132199A (zh) * | 2017-04-26 | 2017-09-05 | 上海健康医学院 | 一种血清中肌酐含量近红外光谱测定方法 |
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KR20210050967A (ko) * | 2019-10-29 | 2021-05-10 | 삼성전자주식회사 | 분석 물질의 농도 추정 장치 및 방법과, 캘리브레이션 방법 |
CN112515667A (zh) * | 2020-12-01 | 2021-03-19 | 戴昊霖 | 一种无创血糖估计方法 |
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2003
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2004
- 2004-03-18 US US10/802,920 patent/US7248911B2/en active Active
- 2004-03-18 JP JP2004079140A patent/JP2004283585A/ja not_active Withdrawn
- 2004-03-19 EP EP20040251608 patent/EP1459679B1/en not_active Expired - Fee Related
- 2004-03-19 DE DE200460001075 patent/DE602004001075T2/de not_active Expired - Lifetime
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EP1665980A1 (en) | 2006-06-07 |
DE602004001075T2 (de) | 2007-01-04 |
US7248911B2 (en) | 2007-07-24 |
US20040186364A1 (en) | 2004-09-23 |
EP1459679B1 (en) | 2006-06-07 |
JP2004283585A (ja) | 2004-10-14 |
CN1550209A (zh) | 2004-12-01 |
EP1459679A1 (en) | 2004-09-22 |
DE602004001075D1 (de) | 2006-07-20 |
CN1313051C (zh) | 2007-05-02 |
KR20040082554A (ko) | 2004-09-30 |
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